#METABOLOMICS WORKBENCH xuz1_20250707_132016 DATATRACK_ID:6143 STUDY_ID:ST004057 ANALYSIS_ID:AN006705 PROJECT_ID:PR002547
VERSION             	1
CREATED_ON             	July 22, 2025, 10:50 am
#PROJECT
PR:PROJECT_TITLE                 	Microglial and Non-Microglial Regulation of Lipid Metabolism in Alzheimer's
PR:PROJECT_TITLE                 	Revealed by Genetic and Pharmacological Depletion
PR:PROJECT_SUMMARY               	Abnormal lipid metabolism is observed in Alzheimer’s disease (AD), but its
PR:PROJECT_SUMMARY               	contribution to disease progression remains unclear. Genetic studies indicate
PR:PROJECT_SUMMARY               	that microglia, the brain’s resident immune cells, influence lipid processing
PR:PROJECT_SUMMARY               	during AD. Here we show that, in both mouse models of AD and human postmortem
PR:PROJECT_SUMMARY               	brain tissue, microglia regulate the accumulation of specific lipids associated
PR:PROJECT_SUMMARY               	with disease pathology. Using multidimensional mass spectrometry-based shotgun
PR:PROJECT_SUMMARY               	lipidomics and histological analysis, we find that arachidonic acid-containing
PR:PROJECT_SUMMARY               	bis(monoacylglycero)phosphate (BMP) accumulates in response to amyloid plaques,
PR:PROJECT_SUMMARY               	and this buildup depends on microglial function and the AD risk gene progranulin
PR:PROJECT_SUMMARY               	(GRN). In contrast, lysophosphatidylcholine (LPC) and
PR:PROJECT_SUMMARY               	lysophosphatidylethanolamine (LPE) accumulate independently of microglia,
PR:PROJECT_SUMMARY               	instead associating with astrocyte activation and oxidative stress. These
PR:PROJECT_SUMMARY               	findings connect dysregulated lipid metabolism in AD to distinct brain cell
PR:PROJECT_SUMMARY               	types and molecular pathways. The results suggest that microglial regulation of
PR:PROJECT_SUMMARY               	lipid homeostasis is a potential therapeutic target for AD.
PR:INSTITUTE                     	UT Health San Antonio
PR:DEPARTMENT                    	Department of Medicine
PR:LABORATORY                    	Xianlin Han Lab
PR:LAST_NAME                     	Han
PR:FIRST_NAME                    	Xianlin
PR:ADDRESS                       	7703 Floyd Curl Drive
PR:EMAIL                         	hanx@uthscsa.edu
PR:PHONE                         	2105624104
#STUDY
ST:STUDY_TITLE                   	Microglial and Non-Microglial Regulation of Lipid Metabolism in Alzheimer's
ST:STUDY_TITLE                   	Revealed by Genetic and Pharmacological Depletion
ST:STUDY_SUMMARY                 	Abnormal lipid metabolism is observed in Alzheimer’s disease (AD), but its
ST:STUDY_SUMMARY                 	contribution to disease progression remains unclear. Genetic studies indicate
ST:STUDY_SUMMARY                 	that microglia, the brain’s resident immune cells, influence lipid processing
ST:STUDY_SUMMARY                 	during AD. Here we show that, in both mouse models of AD and human postmortem
ST:STUDY_SUMMARY                 	brain tissue, microglia regulate the accumulation of specific lipids associated
ST:STUDY_SUMMARY                 	with disease pathology. Using multidimensional mass spectrometry-based shotgun
ST:STUDY_SUMMARY                 	lipidomics and histological analysis, we find that arachidonic acid-containing
ST:STUDY_SUMMARY                 	bis(monoacylglycero)phosphate (BMP) accumulates in response to amyloid plaques,
ST:STUDY_SUMMARY                 	and this buildup depends on microglial function and the AD risk gene progranulin
ST:STUDY_SUMMARY                 	(GRN). In contrast, lysophosphatidylcholine (LPC) and
ST:STUDY_SUMMARY                 	lysophosphatidylethanolamine (LPE) accumulate independently of microglia,
ST:STUDY_SUMMARY                 	instead associating with astrocyte activation and oxidative stress. These
ST:STUDY_SUMMARY                 	findings connect dysregulated lipid metabolism in AD to distinct brain cell
ST:STUDY_SUMMARY                 	types and molecular pathways. The results suggest that microglial regulation of
ST:STUDY_SUMMARY                 	lipid homeostasis is a potential therapeutic target for AD.
ST:INSTITUTE                     	UT Health San Antonio
ST:DEPARTMENT                    	Department of Medicine
ST:LABORATORY                    	Xianlin Han Lab
ST:LAST_NAME                     	Han
ST:FIRST_NAME                    	Xianlin
ST:ADDRESS                       	7703 Floyd Curl Drive
ST:EMAIL                         	hanx@uthscsa.edu
ST:PHONE                         	2105624104
#SUBJECT
SU:SUBJECT_TYPE                  	Mammal
SU:SUBJECT_SPECIES               	Homo sapiens; Mus musculus
SU:TAXONOMY_ID                   	9606; 10090
SU:GENDER                        	Male and female
#SUBJECT_SAMPLE_FACTORS:         	SUBJECT(optional)[tab]SAMPLE[tab]FACTORS(NAME:VALUE pairs separated by |)[tab]Raw file names and additional sample data
SUBJECT_SAMPLE_FACTORS           	-	H_Control-1	Subject_ID:Control | Treatment:/ | Subject Species:Human | Sex:Male | Sample source:Brodmann area 38	RAW_FILE_NAME(Raw file name)=H_CAR-01  H_Cer-01  H_DG-H-01  H_DG-Li-01  H_PC-01  H_PE-01  H_QE-01
SUBJECT_SAMPLE_FACTORS           	-	H_Control-2	Subject_ID:Control | Treatment:/ | Subject Species:Human | Sex:Male | Sample source:Brodmann area 38	RAW_FILE_NAME(Raw file name)=H_CAR-02  H_Cer-02  H_DG-H-02  H_DG-Li-02  H_PC-02  H_PE-02  H_QE-02
SUBJECT_SAMPLE_FACTORS           	-	H_Control-3	Subject_ID:Control | Treatment:/ | Subject Species:Human | Sex:Female | Sample source:Brodmann area 38	RAW_FILE_NAME(Raw file name)=H_CAR-03  H_Cer-03  H_DG-H-03  H_DG-Li-03  H_PC-03  H_PE-03  H_QE-03
SUBJECT_SAMPLE_FACTORS           	-	H_Control-4	Subject_ID:Control | Treatment:/ | Subject Species:Human | Sex:Male | Sample source:Brodmann area 38	RAW_FILE_NAME(Raw file name)=H_CAR-04  H_Cer-04  H_DG-H-04  H_DG-Li-04  H_PC-04  H_PE-04  H_QE-04
SUBJECT_SAMPLE_FACTORS           	-	H_Control-5	Subject_ID:Control | Treatment:/ | Subject Species:Human | Sex:Female | Sample source:Brodmann area 38	RAW_FILE_NAME(Raw file name)=H_CAR-05  H_Cer-05  H_DG-H-05  H_DG-Li-05  H_PC-05  H_PE-05  H_QE-05
SUBJECT_SAMPLE_FACTORS           	-	H_Control-6	Subject_ID:Control | Treatment:/ | Subject Species:Human | Sex:Male | Sample source:Brodmann area 38	RAW_FILE_NAME(Raw file name)=H_CAR-06  H_Cer-06  H_DG-H-06  H_DG-Li-06  H_PC-06  H_PE-06  H_QE-06
SUBJECT_SAMPLE_FACTORS           	-	H_Control-7	Subject_ID:Control | Treatment:/ | Subject Species:Human | Sex:Male | Sample source:Brodmann area 38	RAW_FILE_NAME(Raw file name)=H_CAR-07  H_Cer-07  H_DG-H-07  H_DG-Li-07  H_PC-07  H_PE-07  H_QE-07
SUBJECT_SAMPLE_FACTORS           	-	H_Control-8	Subject_ID:Control | Treatment:/ | Subject Species:Human | Sex:Male | Sample source:Brodmann area 38	RAW_FILE_NAME(Raw file name)=H_CAR-08  H_Cer-08  H_DG-H-08  H_DG-Li-08  H_PC-08  H_PE-08  H_QE-08
SUBJECT_SAMPLE_FACTORS           	-	H_Control-9	Subject_ID:Control | Treatment:/ | Subject Species:Human | Sex:Female | Sample source:Brodmann area 38	RAW_FILE_NAME(Raw file name)=H_CAR-09  H_Cer-09  H_DG-H-09  H_DG-Li-09  H_PC-09  H_PE-09  H_QE-09
SUBJECT_SAMPLE_FACTORS           	-	H_Control-10	Subject_ID:Control | Treatment:/ | Subject Species:Human | Sex:Female | Sample source:Brodmann area 38	RAW_FILE_NAME(Raw file name)=H_CAR-10  H_Cer-10  H_DG-H-10  H_DG-Li-10  H_PC-10  H_PE-10  H_QE-10
SUBJECT_SAMPLE_FACTORS           	-	H_AD-1	Subject_ID:AD | Treatment:/ | Subject Species:Human | Sex:Male | Sample source:Brodmann area 38	RAW_FILE_NAME(Raw file name)=H_CAR-21  H_Cer-21  H_DG-H-21  H_DG-Li-21  H_PC-21  H_PE-21  H_QE-21
SUBJECT_SAMPLE_FACTORS           	-	H_AD-2	Subject_ID:AD | Treatment:/ | Subject Species:Human | Sex:Male | Sample source:Brodmann area 38	RAW_FILE_NAME(Raw file name)=H_CAR-22  H_Cer-22  H_DG-H-22  H_DG-Li-22  H_PC-22  H_PE-22  H_QE-22
SUBJECT_SAMPLE_FACTORS           	-	H_AD-3	Subject_ID:AD | Treatment:/ | Subject Species:Human | Sex:Female | Sample source:Brodmann area 38	RAW_FILE_NAME(Raw file name)=H_CAR-23  H_Cer-23  H_DG-H-23  H_DG-Li-23  H_PC-23  H_PE-23  H_QE-23
SUBJECT_SAMPLE_FACTORS           	-	H_AD-4	Subject_ID:AD | Treatment:/ | Subject Species:Human | Sex:Male | Sample source:Brodmann area 38	RAW_FILE_NAME(Raw file name)=H_CAR-24  H_Cer-24  H_DG-H-24  H_DG-Li-24  H_PC-24  H_PE-24  H_QE-24
SUBJECT_SAMPLE_FACTORS           	-	H_AD-5	Subject_ID:AD | Treatment:/ | Subject Species:Human | Sex:Male | Sample source:Brodmann area 38	RAW_FILE_NAME(Raw file name)=H_CAR-25  H_Cer-25  H_DG-H-25  H_DG-Li-25  H_PC-25  H_PE-25  H_QE-25
SUBJECT_SAMPLE_FACTORS           	-	H_AD-6	Subject_ID:AD | Treatment:/ | Subject Species:Human | Sex:Female | Sample source:Brodmann area 38	RAW_FILE_NAME(Raw file name)=H_CAR-26  H_Cer-26  H_DG-H-26  H_DG-Li-26  H_PC-26  H_PE-26  H_QE-26
SUBJECT_SAMPLE_FACTORS           	-	H_AD-7	Subject_ID:AD | Treatment:/ | Subject Species:Human | Sex:Male | Sample source:Brodmann area 38	RAW_FILE_NAME(Raw file name)=H_CAR-27  H_Cer-27  H_DG-H-27  H_DG-Li-27  H_PC-27  H_PE-27  H_QE-27
SUBJECT_SAMPLE_FACTORS           	-	H_AD-8	Subject_ID:AD | Treatment:/ | Subject Species:Human | Sex:Female | Sample source:Brodmann area 38	RAW_FILE_NAME(Raw file name)=H_CAR-28  H_Cer-28  H_DG-H-28  H_DG-Li-28  H_PC-28  H_PE-28  H_QE-28
SUBJECT_SAMPLE_FACTORS           	-	H_AD-9	Subject_ID:AD | Treatment:/ | Subject Species:Human | Sex:Male | Sample source:Brodmann area 38	RAW_FILE_NAME(Raw file name)=H_CAR-29  H_Cer-29  H_DG-H-29  H_DG-Li-29  H_PC-29  H_PE-29  H_QE-29
SUBJECT_SAMPLE_FACTORS           	-	H_AD-10	Subject_ID:AD | Treatment:/ | Subject Species:Human | Sex:Female | Sample source:Brodmann area 38	RAW_FILE_NAME(Raw file name)=H_CAR-30  H_Cer-30  H_DG-H-30  H_DG-Li-30  H_PC-30  H_PE-30  H_QE-30
SUBJECT_SAMPLE_FACTORS           	-	G_Non-Tg-1	Subject_ID:Non-tansgenic | Treatment:OSD chow | Subject Species:Mus musculus | Sex:Female | Sample source:Cerebrum	RAW_FILE_NAME(Raw file name)=G_CAR-15  G_Cer-15  G_DG-H-15  G_DG-Li-15  G_HexCer-15  G_LPC-15  G_LPE-15  G_PC-15  G_PE-15  G_QE-15  G_SM-15
SUBJECT_SAMPLE_FACTORS           	-	G_Non-Tg-2	Subject_ID:Non-tansgenic | Treatment:OSD chow | Subject Species:Mus musculus | Sex:Female | Sample source:Cerebrum	RAW_FILE_NAME(Raw file name)=G_CAR-16  G_Cer-16  G_DG-H-16  G_DG-Li-16  G_HexCer-16  G_LPC-16  G_LPE-16  G_PC-16  G_PE-16  G_QE-16  G_SM-16
SUBJECT_SAMPLE_FACTORS           	-	G_Non-Tg-3	Subject_ID:Non-tansgenic | Treatment:OSD chow | Subject Species:Mus musculus | Sex:Female | Sample source:Cerebrum	RAW_FILE_NAME(Raw file name)=G_CAR-17  G_Cer-17  G_DG-H-17  G_DG-Li-17  G_HexCer-17  G_LPC-17  G_LPE-17  G_PC-17  G_PE-17  G_QE-17  G_SM-17
SUBJECT_SAMPLE_FACTORS           	-	G_Non-Tg-4	Subject_ID:Non-tansgenic | Treatment:OSD chow | Subject Species:Mus musculus | Sex:Female | Sample source:Cerebrum	RAW_FILE_NAME(Raw file name)=G_CAR-18  G_Cer-18  G_DG-H-18  G_DG-Li-18  G_HexCer-18  G_LPC-18  G_LPE-18  G_PC-18  G_PE-18  G_QE-18  G_SM-18
SUBJECT_SAMPLE_FACTORS           	-	G_Non-Tg-5	Subject_ID:Non-tansgenic | Treatment:OSD chow | Subject Species:Mus musculus | Sex:Male | Sample source:Cerebrum	RAW_FILE_NAME(Raw file name)=G_CAR-19  G_Cer-19  G_DG-H-19  G_DG-Li-19  G_HexCer-19  G_LPC-19  G_LPE-19  G_PC-19  G_PE-19  G_QE-19  G_SM-19
SUBJECT_SAMPLE_FACTORS           	-	G_Non-Tg-6	Subject_ID:Non-tansgenic | Treatment:OSD chow | Subject Species:Mus musculus | Sex:Male | Sample source:Cerebrum	RAW_FILE_NAME(Raw file name)=G_CAR-20  G_Cer-20  G_DG-H-20  G_DG-Li-20  G_HexCer-20  G_LPC-20  G_LPE-20  G_PC-20  G_PE-20  G_QE-20  G_SM-20
SUBJECT_SAMPLE_FACTORS           	-	G_Non-Tg-7	Subject_ID:Non-tansgenic | Treatment:OSD chow | Subject Species:Mus musculus | Sex:Male | Sample source:Cerebrum	RAW_FILE_NAME(Raw file name)=G_CAR-21  G_Cer-21  G_DG-H-21  G_DG-Li-21  G_HexCer-21  G_LPC-21  G_LPE-21  G_PC-21  G_PE-21  G_QE-21  G_SM-21
SUBJECT_SAMPLE_FACTORS           	-	G_Non-Tg-8	Subject_ID:Non-tansgenic | Treatment:OSD chow | Subject Species:Mus musculus | Sex:Male | Sample source:Cerebrum	RAW_FILE_NAME(Raw file name)=G_CAR-22  G_Cer-22  G_DG-H-22  G_DG-Li-22  G_HexCer-22  G_LPC-22  G_LPE-22  G_PC-22  G_PE-22  G_QE-22  G_SM-22
SUBJECT_SAMPLE_FACTORS           	-	G_5xFAD-1	Subject_ID:5xFAD | Treatment:OSD chow | Subject Species:Mus musculus | Sex:Female | Sample source:Cerebrum	RAW_FILE_NAME(Raw file name)=G_CAR-07  G_Cer-07  G_DG-H-07  G_DG-Li-07  G_HexCer-07  G_LPC-07  G_LPE-07  G_PC-07  G_PE-07  G_QE-07  G_SM-07
SUBJECT_SAMPLE_FACTORS           	-	G_5xFAD-2	Subject_ID:5xFAD | Treatment:OSD chow | Subject Species:Mus musculus | Sex:Female | Sample source:Cerebrum	RAW_FILE_NAME(Raw file name)=G_CAR-08  G_Cer-08  G_DG-H-08  G_DG-Li-08  G_HexCer-08  G_LPC-08  G_LPE-08  G_PC-08  G_PE-08  G_QE-08  G_SM-08
SUBJECT_SAMPLE_FACTORS           	-	G_5xFAD-3	Subject_ID:5xFAD | Treatment:OSD chow | Subject Species:Mus musculus | Sex:Female | Sample source:Cerebrum	RAW_FILE_NAME(Raw file name)=G_CAR-09  G_Cer-09  G_DG-H-09  G_DG-Li-09  G_HexCer-09  G_LPC-09  G_LPE-09  G_PC-09  G_PE-09  G_QE-09  G_SM-09
SUBJECT_SAMPLE_FACTORS           	-	G_5xFAD-4	Subject_ID:5xFAD | Treatment:OSD chow | Subject Species:Mus musculus | Sex:Female | Sample source:Cerebrum	RAW_FILE_NAME(Raw file name)=G_CAR-10  G_Cer-10  G_DG-H-10  G_DG-Li-10  G_HexCer-10  G_LPC-10  G_LPE-10  G_PC-10  G_PE-10  G_QE-10  G_SM-10
SUBJECT_SAMPLE_FACTORS           	-	G_5xFAD-5	Subject_ID:5xFAD | Treatment:OSD chow | Subject Species:Mus musculus | Sex:Male | Sample source:Cerebrum	RAW_FILE_NAME(Raw file name)=G_CAR-11  G_Cer-11  G_DG-H-11  G_DG-Li-11  G_HexCer-11  G_LPC-11  G_LPE-11  G_PC-11  G_PE-11  G_QE-11  G_SM-11
SUBJECT_SAMPLE_FACTORS           	-	G_5xFAD-6	Subject_ID:5xFAD | Treatment:OSD chow | Subject Species:Mus musculus | Sex:Male | Sample source:Cerebrum	RAW_FILE_NAME(Raw file name)=G_CAR-12  G_Cer-12  G_DG-H-12  G_DG-Li-12  G_HexCer-12  G_LPC-12  G_LPE-12  G_PC-12  G_PE-12  G_QE-12  G_SM-12
SUBJECT_SAMPLE_FACTORS           	-	G_5xFAD-7	Subject_ID:5xFAD | Treatment:OSD chow | Subject Species:Mus musculus | Sex:Male | Sample source:Cerebrum	RAW_FILE_NAME(Raw file name)=G_CAR-13  G_Cer-13  G_DG-H-13  G_DG-Li-13  G_HexCer-13  G_LPC-13  G_LPE-13  G_PC-13  G_PE-13  G_QE-13  G_SM-13
SUBJECT_SAMPLE_FACTORS           	-	G_5xFAD-8	Subject_ID:5xFAD | Treatment:OSD chow | Subject Species:Mus musculus | Sex:Male | Sample source:Cerebrum	RAW_FILE_NAME(Raw file name)=G_CAR-14  G_Cer-14  G_DG-H-14  G_DG-Li-14  G_HexCer-14  G_LPC-14  G_LPE-14  G_PC-14  G_PE-14  G_QE-14  G_SM-14
SUBJECT_SAMPLE_FACTORS           	-	G_FIRE-1	Subject_ID:FIRE | Treatment:OSD chow | Subject Species:Mus musculus | Sex:Female | Sample source:Cerebrum	RAW_FILE_NAME(Raw file name)=G_CAR-23  G_Cer-23  G_DG-H-23  G_DG-Li-23  G_HexCer-23  G_LPC-23  G_LPE-23  G_PC-23  G_PE-23  G_QE-23  G_SM-23
SUBJECT_SAMPLE_FACTORS           	-	G_FIRE-2	Subject_ID:FIRE | Treatment:OSD chow | Subject Species:Mus musculus | Sex:Female | Sample source:Cerebrum	RAW_FILE_NAME(Raw file name)=G_CAR-24  G_Cer-24  G_DG-H-24  G_DG-Li-24  G_HexCer-24  G_LPC-24  G_LPE-24  G_PC-24  G_PE-24  G_QE-24  G_SM-24
SUBJECT_SAMPLE_FACTORS           	-	G_FIRE-3	Subject_ID:FIRE | Treatment:OSD chow | Subject Species:Mus musculus | Sex:Female | Sample source:Cerebrum	RAW_FILE_NAME(Raw file name)=G_CAR-25  G_Cer-25  G_DG-H-25  G_DG-Li-25  G_HexCer-25  G_LPC-25  G_LPE-25  G_PC-25  G_PE-25  G_QE-25  G_SM-25
SUBJECT_SAMPLE_FACTORS           	-	G_FIRE-4	Subject_ID:FIRE | Treatment:OSD chow | Subject Species:Mus musculus | Sex:Female | Sample source:Cerebrum	RAW_FILE_NAME(Raw file name)=G_CAR-26  G_Cer-26  G_DG-H-26  G_DG-Li-26  G_HexCer-26  G_LPC-26  G_LPE-26  G_PC-26  G_PE-26  G_QE-26  G_SM-26
SUBJECT_SAMPLE_FACTORS           	-	G_FIRE-5	Subject_ID:FIRE | Treatment:OSD chow | Subject Species:Mus musculus | Sex:Male | Sample source:Cerebrum	RAW_FILE_NAME(Raw file name)=G_CAR-27  G_Cer-27  G_DG-H-27  G_DG-Li-27  G_HexCer-27  G_LPC-27  G_LPE-27  G_PC-27  G_PE-27  G_QE-27  G_SM-27
SUBJECT_SAMPLE_FACTORS           	-	G_FIRE-6	Subject_ID:FIRE | Treatment:OSD chow | Subject Species:Mus musculus | Sex:Male | Sample source:Cerebrum	RAW_FILE_NAME(Raw file name)=G_CAR-28  G_Cer-28  G_DG-H-28  G_DG-Li-28  G_HexCer-28  G_LPC-28  G_LPE-28  G_PC-28  G_PE-28  G_QE-28  G_SM-28
SUBJECT_SAMPLE_FACTORS           	-	G_FIRE-7	Subject_ID:FIRE | Treatment:OSD chow | Subject Species:Mus musculus | Sex:Male | Sample source:Cerebrum	RAW_FILE_NAME(Raw file name)=G_CAR-29  G_Cer-29  G_DG-H-29  G_DG-Li-29  G_HexCer-29  G_LPC-29  G_LPE-29  G_PC-29  G_PE-29  G_QE-29  G_SM-29
SUBJECT_SAMPLE_FACTORS           	-	G_5xFIRE-1	Subject_ID:5xFIRE | Treatment:OSD chow | Subject Species:Mus musculus | Sex:Female | Sample source:Cerebrum	RAW_FILE_NAME(Raw file name)=G_CAR-01  G_Cer-01  G_DG-H-01  G_DG-Li-01  G_HexCer-01  G_LPC-01  G_LPE-01  G_PC-01  G_PE-01  G_QE-01  G_SM-01
SUBJECT_SAMPLE_FACTORS           	-	G_5xFIRE-2	Subject_ID:5xFIRE | Treatment:OSD chow | Subject Species:Mus musculus | Sex:Female | Sample source:Cerebrum	RAW_FILE_NAME(Raw file name)=G_CAR-02  G_Cer-02  G_DG-H-02  G_DG-Li-02  G_HexCer-02  G_LPC-02  G_LPE-02  G_PC-02  G_PE-02  G_QE-02  G_SM-02
SUBJECT_SAMPLE_FACTORS           	-	G_5xFIRE-3	Subject_ID:5xFIRE | Treatment:OSD chow | Subject Species:Mus musculus | Sex:Female | Sample source:Cerebrum	RAW_FILE_NAME(Raw file name)=G_CAR-03  G_Cer-03  G_DG-H-03  G_DG-Li-03  G_HexCer-03  G_LPC-03  G_LPE-03  G_PC-03  G_PE-03  G_QE-03  G_SM-03
SUBJECT_SAMPLE_FACTORS           	-	G_5xFIRE-4	Subject_ID:5xFIRE | Treatment:OSD chow | Subject Species:Mus musculus | Sex:Male | Sample source:Cerebrum	RAW_FILE_NAME(Raw file name)=G_CAR-04  G_Cer-04  G_DG-H-04  G_DG-Li-04  G_HexCer-04  G_LPC-04  G_LPE-04  G_PC-04  G_PE-04  G_QE-04  G_SM-04
SUBJECT_SAMPLE_FACTORS           	-	G_5xFIRE-5	Subject_ID:5xFIRE | Treatment:OSD chow | Subject Species:Mus musculus | Sex:Male | Sample source:Cerebrum	RAW_FILE_NAME(Raw file name)=G_CAR-05  G_Cer-05  G_DG-H-05  G_DG-Li-05  G_HexCer-05  G_LPC-05  G_LPE-05  G_PC-05  G_PE-05  G_QE-05  G_SM-05
SUBJECT_SAMPLE_FACTORS           	-	LP_Non-Tg-1	Subject_ID:Non-tansgenic | Treatment:OSD chow | Subject Species:Mus musculus | Sex:Female | Sample source:Cerebrum	RAW_FILE_NAME(Raw file name)=LP_CAR-01  LP_Cer-01  LP_DG-H-01  LP_DG-Li-01  LP_HexCer-01  LP_HNE-01  LP_LPC-01  LP_LPE-01  LP_PC-01  LP_PE-01  LP_QE-01
SUBJECT_SAMPLE_FACTORS           	-	LP_Non-Tg-2	Subject_ID:Non-tansgenic | Treatment:OSD chow | Subject Species:Mus musculus | Sex:Female | Sample source:Cerebrum	RAW_FILE_NAME(Raw file name)=LP_CAR-02  LP_Cer-02  LP_DG-H-02  LP_DG-Li-02  LP_HexCer-02  LP_HNE-02  LP_LPC-02  LP_LPE-02  LP_PC-02  LP_PE-02  LP_QE-02
SUBJECT_SAMPLE_FACTORS           	-	LP_Non-Tg-3	Subject_ID:Non-tansgenic | Treatment:OSD chow | Subject Species:Mus musculus | Sex:Female | Sample source:Cerebrum	RAW_FILE_NAME(Raw file name)=LP_CAR-03  LP_Cer-03  LP_DG-H-03  LP_DG-Li-03  LP_HexCer-03  LP_HNE-03  LP_LPC-03  LP_LPE-03  LP_PC-03  LP_PE-03  LP_QE-03
SUBJECT_SAMPLE_FACTORS           	-	LP_Non-Tg-4	Subject_ID:Non-tansgenic | Treatment:OSD chow | Subject Species:Mus musculus | Sex:Female | Sample source:Cerebrum	RAW_FILE_NAME(Raw file name)=LP_CAR-04  LP_Cer-04  LP_DG-H-04  LP_DG-Li-04  LP_HexCer-04  LP_HNE-04  LP_LPC-04  LP_LPE-04  LP_PC-04  LP_PE-04  LP_QE-04
SUBJECT_SAMPLE_FACTORS           	-	LP_Non-Tg-5	Subject_ID:Non-tansgenic | Treatment:OSD chow | Subject Species:Mus musculus | Sex:Female | Sample source:Cerebrum	RAW_FILE_NAME(Raw file name)=LP_CAR-05  LP_Cer-05  LP_DG-H-05  LP_DG-Li-05  LP_HexCer-05  LP_HNE-05  LP_LPC-05  LP_LPE-05  LP_PC-05  LP_PE-05  LP_QE-05
SUBJECT_SAMPLE_FACTORS           	-	LP_5xFAD-1	Subject_ID:5xFAD | Treatment:OSD chow | Subject Species:Mus musculus | Sex:Female | Sample source:Cerebrum	RAW_FILE_NAME(Raw file name)=LP_CAR-06  LP_Cer-06  LP_DG-H-06  LP_DG-Li-06  LP_HexCer-06  LP_HNE-06  LP_LPC-06  LP_LPE-06  LP_PC-06  LP_PE-06  LP_QE-06
SUBJECT_SAMPLE_FACTORS           	-	LP_5xFAD-2	Subject_ID:5xFAD | Treatment:OSD chow | Subject Species:Mus musculus | Sex:Female | Sample source:Cerebrum	RAW_FILE_NAME(Raw file name)=LP_CAR-07  LP_Cer-07  LP_DG-H-07  LP_DG-Li-07  LP_HexCer-07  LP_HNE-07  LP_LPC-07  LP_LPE-07  LP_PC-07  LP_PE-07  LP_QE-07
SUBJECT_SAMPLE_FACTORS           	-	LP_5xFAD-3	Subject_ID:5xFAD | Treatment:OSD chow | Subject Species:Mus musculus | Sex:Female | Sample source:Cerebrum	RAW_FILE_NAME(Raw file name)=LP_CAR-08  LP_Cer-08  LP_DG-H-08  LP_DG-Li-08  LP_HexCer-08  LP_HNE-08  LP_LPC-08  LP_LPE-08  LP_PC-08  LP_PE-08  LP_QE-08
SUBJECT_SAMPLE_FACTORS           	-	LP_5xFAD-4	Subject_ID:5xFAD | Treatment:OSD chow | Subject Species:Mus musculus | Sex:Female | Sample source:Cerebrum	RAW_FILE_NAME(Raw file name)=LP_CAR-09  LP_Cer-09  LP_DG-H-09  LP_DG-Li-09  LP_HexCer-09  LP_HNE-09  LP_LPC-09  LP_LPE-09  LP_PC-09  LP_PE-09  LP_QE-09
SUBJECT_SAMPLE_FACTORS           	-	LP_5xFAD-5	Subject_ID:5xFAD | Treatment:OSD chow | Subject Species:Mus musculus | Sex:Female | Sample source:Cerebrum	RAW_FILE_NAME(Raw file name)=LP_CAR-10  LP_Cer-10  LP_DG-H-10  LP_DG-Li-10  LP_HexCer-10  LP_HNE-10  LP_LPC-10  LP_LPE-10  LP_PC-10  LP_PE-10  LP_QE-10
SUBJECT_SAMPLE_FACTORS           	-	LP_5xFAD-6	Subject_ID:5xFAD | Treatment:OSD chow | Subject Species:Mus musculus | Sex:Female | Sample source:Cerebrum	RAW_FILE_NAME(Raw file name)=LP_CAR-11  LP_Cer-11  LP_DG-H-11  LP_DG-Li-11  LP_HexCer-11  LP_HNE-11  LP_LPC-11  LP_LPE-11  LP_PC-11  LP_PE-11  LP_QE-11
SUBJECT_SAMPLE_FACTORS           	-	LP_5xFAD-7	Subject_ID:5xFAD | Treatment:OSD chow | Subject Species:Mus musculus | Sex:Female | Sample source:Cerebrum	RAW_FILE_NAME(Raw file name)=LP_CAR-12  LP_Cer-12  LP_DG-H-12  LP_DG-Li-12  LP_HexCer-12  LP_HNE-12  LP_LPC-12  LP_LPE-12  LP_PC-12  LP_PE-12  LP_QE-12
SUBJECT_SAMPLE_FACTORS           	-	LP_5xFAD-8	Subject_ID:5xFAD | Treatment:OSD chow | Subject Species:Mus musculus | Sex:Female | Sample source:Cerebrum	RAW_FILE_NAME(Raw file name)=LP_CAR-13  LP_Cer-13  LP_DG-H-13  LP_DG-Li-13  LP_HexCer-13  LP_HNE-13  LP_LPC-13  LP_LPE-13  LP_PC-13  LP_PE-13  LP_QE-13
SUBJECT_SAMPLE_FACTORS           	-	LP_5xFAD+PLX5622-1	Subject_ID:5xFAD | Treatment:PLX5622 | Subject Species:Mus musculus | Sex:Female | Sample source:Cerebrum	RAW_FILE_NAME(Raw file name)=LP_CAR-14  LP_Cer-14  LP_DG-H-14  LP_DG-Li-14  LP_HexCer-14  LP_HNE-14  LP_LPC-14  LP_LPE-14  LP_PC-14  LP_PE-14  LP_QE-14
SUBJECT_SAMPLE_FACTORS           	-	LP_5xFAD+PLX5622-2	Subject_ID:5xFAD | Treatment:PLX5622 | Subject Species:Mus musculus | Sex:Female | Sample source:Cerebrum	RAW_FILE_NAME(Raw file name)=LP_CAR-15  LP_Cer-15  LP_DG-H-15  LP_DG-Li-15  LP_HexCer-15  LP_HNE-15  LP_LPC-15  LP_LPE-15  LP_PC-15  LP_PE-15  LP_QE-15
SUBJECT_SAMPLE_FACTORS           	-	LP_5xFAD+PLX5622-3	Subject_ID:5xFAD | Treatment:PLX5622 | Subject Species:Mus musculus | Sex:Female | Sample source:Cerebrum	RAW_FILE_NAME(Raw file name)=LP_CAR-16  LP_Cer-16  LP_DG-H-16  LP_DG-Li-16  LP_HexCer-16  LP_HNE-16  LP_LPC-16  LP_LPE-16  LP_PC-16  LP_PE-16  LP_QE-16
SUBJECT_SAMPLE_FACTORS           	-	LP_5xFAD+PLX5622-4	Subject_ID:5xFAD | Treatment:PLX5622 | Subject Species:Mus musculus | Sex:Female | Sample source:Cerebrum	RAW_FILE_NAME(Raw file name)=LP_CAR-17  LP_Cer-17  LP_DG-H-17  LP_DG-Li-17  LP_HexCer-17  LP_HNE-17  LP_LPC-17  LP_LPE-17  LP_PC-17  LP_PE-17  LP_QE-17
SUBJECT_SAMPLE_FACTORS           	-	LP_5xFAD+PLX5622-5	Subject_ID:5xFAD | Treatment:PLX5622 | Subject Species:Mus musculus | Sex:Female | Sample source:Cerebrum	RAW_FILE_NAME(Raw file name)=LP_CAR-18  LP_Cer-18  LP_DG-H-18  LP_DG-Li-18  LP_HexCer-18  LP_HNE-18  LP_LPC-18  LP_LPE-18  LP_PC-18  LP_PE-18  LP_QE-18
SUBJECT_SAMPLE_FACTORS           	-	LP_5xFAD+PLX5622-6	Subject_ID:5xFAD | Treatment:PLX5622 | Subject Species:Mus musculus | Sex:Female | Sample source:Cerebrum	RAW_FILE_NAME(Raw file name)=LP_CAR-19  LP_Cer-19  LP_DG-H-19  LP_DG-Li-19  LP_HexCer-19  LP_HNE-19  LP_LPC-19  LP_LPE-19  LP_PC-19  LP_PE-19  LP_QE-19
SUBJECT_SAMPLE_FACTORS           	-	LP_5xFAD+PLX5622-7	Subject_ID:5xFAD | Treatment:PLX5622 | Subject Species:Mus musculus | Sex:Female | Sample source:Cerebrum	RAW_FILE_NAME(Raw file name)=LP_CAR-20  LP_Cer-20  LP_DG-H-20  LP_DG-Li-20  LP_HexCer-20  LP_HNE-20  LP_LPC-20  LP_LPE-20  LP_PC-20  LP_PE-20  LP_QE-20
SUBJECT_SAMPLE_FACTORS           	-	LP_5xFAD+PLX5622-8	Subject_ID:5xFAD | Treatment:PLX5622 | Subject Species:Mus musculus | Sex:Female | Sample source:Cerebrum	RAW_FILE_NAME(Raw file name)=LP_CAR-21  LP_Cer-21  LP_DG-H-21  LP_DG-Li-21  LP_HexCer-21  LP_HNE-21  LP_LPC-21  LP_LPE-21  LP_PC-21  LP_PE-21  LP_QE-21
SUBJECT_SAMPLE_FACTORS           	-	SP_Non-Tg-1	Subject_ID:Non-tansgenic | Treatment:OSD chow | Subject Species:Mus musculus | Sex:Female | Sample source:Cerebrum	RAW_FILE_NAME(Raw file name)=LP_LPC,SM,HexCer-16  LP_LPE-16  LP_PC-16  LP_PE-16  LP_QE-16
SUBJECT_SAMPLE_FACTORS           	-	SP_Non-Tg-2	Subject_ID:Non-tansgenic | Treatment:OSD chow | Subject Species:Mus musculus | Sex:Female | Sample source:Cerebrum	RAW_FILE_NAME(Raw file name)=LP_LPC,SM,HexCer-17  LP_LPE-17  LP_PC-17  LP_PE-17  LP_QE-17
SUBJECT_SAMPLE_FACTORS           	-	SP_Non-Tg-3	Subject_ID:Non-tansgenic | Treatment:OSD chow | Subject Species:Mus musculus | Sex:Female | Sample source:Cerebrum	RAW_FILE_NAME(Raw file name)=LP_LPC,SM,HexCer-18  LP_LPE-18  LP_PC-18  LP_PE-18  LP_QE-18
SUBJECT_SAMPLE_FACTORS           	-	SP_Non-Tg-4	Subject_ID:Non-tansgenic | Treatment:OSD chow | Subject Species:Mus musculus | Sex:Female | Sample source:Cerebrum	RAW_FILE_NAME(Raw file name)=LP_LPC,SM,HexCer-19  LP_LPE-19  LP_PC-19  LP_PE-19  LP_QE-19
SUBJECT_SAMPLE_FACTORS           	-	SP_Non-Tg-5	Subject_ID:Non-tansgenic | Treatment:OSD chow | Subject Species:Mus musculus | Sex:Female | Sample source:Cerebrum	RAW_FILE_NAME(Raw file name)=LP_LPC,SM,HexCer-20  LP_LPE-20  LP_PC-20  LP_PE-20  LP_QE-20
SUBJECT_SAMPLE_FACTORS           	-	SP_Non-Tg-6	Subject_ID:Non-tansgenic | Treatment:OSD chow | Subject Species:Mus musculus | Sex:Female | Sample source:Cerebrum	RAW_FILE_NAME(Raw file name)=LP_LPC,SM,HexCer-36  LP_LPE-36  LP_PC-36  LP_PE-36  LP_QE-36
SUBJECT_SAMPLE_FACTORS           	-	SP_Non-Tg-7	Subject_ID:Non-tansgenic | Treatment:OSD chow | Subject Species:Mus musculus | Sex:Female | Sample source:Cerebrum	RAW_FILE_NAME(Raw file name)=LP_LPC,SM,HexCer-37  LP_LPE-37  LP_PC-37  LP_PE-37  LP_QE-37
SUBJECT_SAMPLE_FACTORS           	-	SP_Non-Tg-8	Subject_ID:Non-tansgenic | Treatment:OSD chow | Subject Species:Mus musculus | Sex:Female | Sample source:Cerebrum	RAW_FILE_NAME(Raw file name)=LP_LPC,SM,HexCer-38  LP_LPE-38  LP_PC-38  LP_PE-38  LP_QE-38
SUBJECT_SAMPLE_FACTORS           	-	SP_Non-Tg-9	Subject_ID:Non-tansgenic | Treatment:OSD chow | Subject Species:Mus musculus | Sex:Female | Sample source:Cerebrum	RAW_FILE_NAME(Raw file name)=LP_LPC,SM,HexCer-39  LP_LPE-39  LP_PC-39  LP_PE-39  LP_QE-39
SUBJECT_SAMPLE_FACTORS           	-	SP_Non-Tg-10	Subject_ID:Non-tansgenic | Treatment:OSD chow | Subject Species:Mus musculus | Sex:Female | Sample source:Cerebrum	RAW_FILE_NAME(Raw file name)=LP_LPC,SM,HexCer-40  LP_LPE-40  LP_PC-40  LP_PE-40  LP_QE-40
SUBJECT_SAMPLE_FACTORS           	-	SP_5xFAD-1	Subject_ID:5xFAD | Treatment:OSD chow | Subject Species:Mus musculus | Sex:Female | Sample source:Cerebrum	RAW_FILE_NAME(Raw file name)=LP_LPC,SM,HexCer-11  LP_LPE-11  LP_PC-11  LP_PE-11  LP_QE-11
SUBJECT_SAMPLE_FACTORS           	-	SP_5xFAD-2	Subject_ID:5xFAD | Treatment:OSD chow | Subject Species:Mus musculus | Sex:Female | Sample source:Cerebrum	RAW_FILE_NAME(Raw file name)=LP_LPC,SM,HexCer-12  LP_LPE-12  LP_PC-12  LP_PE-12  LP_QE-12
SUBJECT_SAMPLE_FACTORS           	-	SP_5xFAD-3	Subject_ID:5xFAD | Treatment:OSD chow | Subject Species:Mus musculus | Sex:Female | Sample source:Cerebrum	RAW_FILE_NAME(Raw file name)=LP_LPC,SM,HexCer-13  LP_LPE-13  LP_PC-13  LP_PE-13  LP_QE-13
SUBJECT_SAMPLE_FACTORS           	-	SP_5xFAD-4	Subject_ID:5xFAD | Treatment:OSD chow | Subject Species:Mus musculus | Sex:Female | Sample source:Cerebrum	RAW_FILE_NAME(Raw file name)=LP_LPC,SM,HexCer-14  LP_LPE-14  LP_PC-14  LP_PE-14  LP_QE-14
SUBJECT_SAMPLE_FACTORS           	-	SP_5xFAD-5	Subject_ID:5xFAD | Treatment:OSD chow | Subject Species:Mus musculus | Sex:Female | Sample source:Cerebrum	RAW_FILE_NAME(Raw file name)=LP_LPC,SM,HexCer-15  LP_LPE-15  LP_PC-15  LP_PE-15  LP_QE-15
SUBJECT_SAMPLE_FACTORS           	-	SP_5xFAD-6	Subject_ID:5xFAD | Treatment:OSD chow | Subject Species:Mus musculus | Sex:Female | Sample source:Cerebrum	RAW_FILE_NAME(Raw file name)=LP_LPC,SM,HexCer-31  LP_LPE-31  LP_PC-31  LP_PE-31  LP_QE-31
SUBJECT_SAMPLE_FACTORS           	-	SP_5xFAD-7	Subject_ID:5xFAD | Treatment:OSD chow | Subject Species:Mus musculus | Sex:Female | Sample source:Cerebrum	RAW_FILE_NAME(Raw file name)=LP_LPC,SM,HexCer-32  LP_LPE-32  LP_PC-32  LP_PE-32  LP_QE-32
SUBJECT_SAMPLE_FACTORS           	-	SP_5xFAD-8	Subject_ID:5xFAD | Treatment:OSD chow | Subject Species:Mus musculus | Sex:Female | Sample source:Cerebrum	RAW_FILE_NAME(Raw file name)=LP_LPC,SM,HexCer-33  LP_LPE-33  LP_PC-33  LP_PE-33  LP_QE-33
SUBJECT_SAMPLE_FACTORS           	-	SP_5xFAD-9	Subject_ID:5xFAD | Treatment:OSD chow | Subject Species:Mus musculus | Sex:Female | Sample source:Cerebrum	RAW_FILE_NAME(Raw file name)=LP_LPC,SM,HexCer-34  LP_LPE-34  LP_PC-34  LP_PE-34  LP_QE-34
SUBJECT_SAMPLE_FACTORS           	-	SP_5xFAD-10	Subject_ID:5xFAD | Treatment:OSD chow | Subject Species:Mus musculus | Sex:Female | Sample source:Cerebrum	RAW_FILE_NAME(Raw file name)=LP_LPC,SM,HexCer-35  LP_LPE-35  LP_PC-35  LP_PE-35  LP_QE-35
SUBJECT_SAMPLE_FACTORS           	-	SP_Non-Tg+PLX5622-1	Subject_ID:Non-tansgenic | Treatment:PLX5622 | Subject Species:Mus musculus | Sex:Female | Sample source:Cerebrum	RAW_FILE_NAME(Raw file name)=LP_LPC,SM,HexCer-06  LP_LPE-06  LP_PC-06  LP_PE-06  LP_QE-06
SUBJECT_SAMPLE_FACTORS           	-	SP_Non-Tg+PLX5622-2	Subject_ID:Non-tansgenic | Treatment:PLX5622 | Subject Species:Mus musculus | Sex:Female | Sample source:Cerebrum	RAW_FILE_NAME(Raw file name)=LP_LPC,SM,HexCer-08  LP_LPE-08  LP_PC-08  LP_PE-08  LP_QE-08
SUBJECT_SAMPLE_FACTORS           	-	SP_Non-Tg+PLX5622-3	Subject_ID:Non-tansgenic | Treatment:PLX5622 | Subject Species:Mus musculus | Sex:Female | Sample source:Cerebrum	RAW_FILE_NAME(Raw file name)=LP_LPC,SM,HexCer-09  LP_LPE-09  LP_PC-09  LP_PE-09  LP_QE-09
SUBJECT_SAMPLE_FACTORS           	-	SP_Non-Tg+PLX5622-4	Subject_ID:Non-tansgenic | Treatment:PLX5622 | Subject Species:Mus musculus | Sex:Female | Sample source:Cerebrum	RAW_FILE_NAME(Raw file name)=LP_LPC,SM,HexCer-10  LP_LPE-10  LP_PC-10  LP_PE-10  LP_QE-10
SUBJECT_SAMPLE_FACTORS           	-	SP_Non-Tg+PLX5622-5	Subject_ID:Non-tansgenic | Treatment:PLX5622 | Subject Species:Mus musculus | Sex:Female | Sample source:Cerebrum	RAW_FILE_NAME(Raw file name)=LP_LPC,SM,HexCer-26  LP_LPE-26  LP_PC-26  LP_PE-26  LP_QE-26
SUBJECT_SAMPLE_FACTORS           	-	SP_Non-Tg+PLX5622-6	Subject_ID:Non-tansgenic | Treatment:PLX5622 | Subject Species:Mus musculus | Sex:Female | Sample source:Cerebrum	RAW_FILE_NAME(Raw file name)=LP_LPC,SM,HexCer-27  LP_LPE-27  LP_PC-27  LP_PE-27  LP_QE-27
SUBJECT_SAMPLE_FACTORS           	-	SP_Non-Tg+PLX5622-7	Subject_ID:Non-tansgenic | Treatment:PLX5622 | Subject Species:Mus musculus | Sex:Female | Sample source:Cerebrum	RAW_FILE_NAME(Raw file name)=LP_LPC,SM,HexCer-28  LP_LPE-28  LP_PC-28  LP_PE-28  LP_QE-28
SUBJECT_SAMPLE_FACTORS           	-	SP_Non-Tg+PLX5622-8	Subject_ID:Non-tansgenic | Treatment:PLX5622 | Subject Species:Mus musculus | Sex:Female | Sample source:Cerebrum	RAW_FILE_NAME(Raw file name)=LP_LPC,SM,HexCer-29  LP_LPE-29  LP_PC-29  LP_PE-29  LP_QE-29
SUBJECT_SAMPLE_FACTORS           	-	SP_Non-Tg+PLX5622-9	Subject_ID:Non-tansgenic | Treatment:PLX5622 | Subject Species:Mus musculus | Sex:Female | Sample source:Cerebrum	RAW_FILE_NAME(Raw file name)=LP_LPC,SM,HexCer-30  LP_LPE-30  LP_PC-30  LP_PE-30  LP_QE-30
SUBJECT_SAMPLE_FACTORS           	-	SP_5xFAD+PLX5622-1	Subject_ID:5xFAD | Treatment:PLX5622 | Subject Species:Mus musculus | Sex:Female | Sample source:Cerebrum	RAW_FILE_NAME(Raw file name)=LP_LPC,SM,HexCer-01  LP_LPE-01  LP_PC-01  LP_PE-01  LP_QE-01
SUBJECT_SAMPLE_FACTORS           	-	SP_5xFAD+PLX5622-2	Subject_ID:5xFAD | Treatment:PLX5622 | Subject Species:Mus musculus | Sex:Female | Sample source:Cerebrum	RAW_FILE_NAME(Raw file name)=LP_LPC,SM,HexCer-02  LP_LPE-02  LP_PC-02  LP_PE-02  LP_QE-02
SUBJECT_SAMPLE_FACTORS           	-	SP_5xFAD+PLX5622-3	Subject_ID:5xFAD | Treatment:PLX5622 | Subject Species:Mus musculus | Sex:Female | Sample source:Cerebrum	RAW_FILE_NAME(Raw file name)=LP_LPC,SM,HexCer-03  LP_LPE-03  LP_PC-03  LP_PE-03  LP_QE-03
SUBJECT_SAMPLE_FACTORS           	-	SP_5xFAD+PLX5622-4	Subject_ID:5xFAD | Treatment:PLX5622 | Subject Species:Mus musculus | Sex:Female | Sample source:Cerebrum	RAW_FILE_NAME(Raw file name)=LP_LPC,SM,HexCer-04  LP_LPE-04  LP_PC-04  LP_PE-04  LP_QE-04
SUBJECT_SAMPLE_FACTORS           	-	SP_5xFAD+PLX5622-5	Subject_ID:5xFAD | Treatment:PLX5622 | Subject Species:Mus musculus | Sex:Female | Sample source:Cerebrum	RAW_FILE_NAME(Raw file name)=LP_LPC,SM,HexCer-05  LP_LPE-05  LP_PC-05  LP_PE-05  LP_QE-05
SUBJECT_SAMPLE_FACTORS           	-	SP_5xFAD+PLX5622-6	Subject_ID:5xFAD | Treatment:PLX5622 | Subject Species:Mus musculus | Sex:Female | Sample source:Cerebrum	RAW_FILE_NAME(Raw file name)=LP_LPC,SM,HexCer-21  LP_LPE-21  LP_PC-21  LP_PE-21  LP_QE-21
SUBJECT_SAMPLE_FACTORS           	-	SP_5xFAD+PLX5622-7	Subject_ID:5xFAD | Treatment:PLX5622 | Subject Species:Mus musculus | Sex:Female | Sample source:Cerebrum	RAW_FILE_NAME(Raw file name)=LP_LPC,SM,HexCer-22  LP_LPE-22  LP_PC-22  LP_PE-22  LP_QE-22
SUBJECT_SAMPLE_FACTORS           	-	SP_5xFAD+PLX5622-8	Subject_ID:5xFAD | Treatment:PLX5622 | Subject Species:Mus musculus | Sex:Female | Sample source:Cerebrum	RAW_FILE_NAME(Raw file name)=LP_LPC,SM,HexCer-23  LP_LPE-23  LP_PC-23  LP_PE-23  LP_QE-23
SUBJECT_SAMPLE_FACTORS           	-	SP_5xFAD+PLX5622-9	Subject_ID:5xFAD | Treatment:PLX5622 | Subject Species:Mus musculus | Sex:Female | Sample source:Cerebrum	RAW_FILE_NAME(Raw file name)=LP_LPC,SM,HexCer-24  LP_LPE-24  LP_PC-24  LP_PE-24  LP_QE-24
SUBJECT_SAMPLE_FACTORS           	-	SP_5xFAD+PLX5622-10	Subject_ID:5xFAD | Treatment:PLX5622 | Subject Species:Mus musculus | Sex:Female | Sample source:Cerebrum	RAW_FILE_NAME(Raw file name)=LP_LPC,SM,HexCer-25  LP_LPE-25  LP_PC-25  LP_PE-25  LP_QE-25
#COLLECTION
CO:COLLECTION_SUMMARY            	This study includes lipidomic profiling of cerebrum from mouse models and BA-38
CO:COLLECTION_SUMMARY            	from postmortem human brain samples. Mouse right hemi-cerebra were dissected
CO:COLLECTION_SUMMARY            	out, placed in cryotubes, and flash-frozen in liquid nitrogen. Human BA-38
CO:COLLECTION_SUMMARY            	samples were obtained from brain bank, received as frozon tissue. Frozen brains
CO:COLLECTION_SUMMARY            	(both mice and human) were lyophilized using a benchtop freeze dryer (Labconco,
CO:COLLECTION_SUMMARY            	Kansas City, MO, USA) under 0.5 vacuum for 48 hours. Lyophilized brain samples
CO:COLLECTION_SUMMARY            	were weighted and transferred to Precellys 0.5 ml tubes pre-filled with small
CO:COLLECTION_SUMMARY            	beads. Dried tissues were powdered using Precellys® Evolution Tissue
CO:COLLECTION_SUMMARY            	Homogenizer (Bertin technologies, Montigny-le-Bretonneux, France) through one
CO:COLLECTION_SUMMARY            	round of manufacture’s “soft program” at 0 °C. Powdered dry cerebrum
CO:COLLECTION_SUMMARY            	tissues were weighted around 5mg for lipidomics using disposable anti-static
CO:COLLECTION_SUMMARY            	spatulas. Dried and powdered tissues were homogenized in 0.1X PBS. Protein
CO:COLLECTION_SUMMARY            	concentrations were measured using a bicinchoninic acid (BCA) assay.
CO:SAMPLE_TYPE                   	Brain
#TREATMENT
TR:TREATMENT_SUMMARY             	5xFAD mice (Tg(APPSwFlLon,PSEN1*M146L*L286V)6799Vas/Mmjax), were obtained from
TR:TREATMENT_SUMMARY             	the Mutant Mouse Resource and Research Center (MMRRC) at The Jackson Laboratory
TR:TREATMENT_SUMMARY             	in two different genetic backgrounds (B6SJL: MMRRC_034840-JAX; and C57BL6:
TR:TREATMENT_SUMMARY             	MMRRC_034848-JAX). Mice were housed under 12/12 h light/dark cycles with free
TR:TREATMENT_SUMMARY             	access to food and water ad libitum. Only female mice were used for the
TR:TREATMENT_SUMMARY             	pharmacological (PLX5622-treated) partial microglial elimination cohorts and
TR:TREATMENT_SUMMARY             	both male and female mice were used for the genetic (FIRE) full microglial
TR:TREATMENT_SUMMARY             	elimination cohort. For the long-term pharmacological group, 1,200 mg of PLX5622
TR:TREATMENT_SUMMARY             	(free base)/kg was added to OpenStandard Diet (OSD) with 15 kcal% fat (Research
TR:TREATMENT_SUMMARY             	diets, INC., New Brunswick, NJ, USA). Control mice were fed with OSD, and
TR:TREATMENT_SUMMARY             	experimental mice with OSD+ PLX5622 from 6 weeks of age until 5 months when
TR:TREATMENT_SUMMARY             	tissues were harvested. For the short-term pharmacological group, 1,200 mg of
TR:TREATMENT_SUMMARY             	PLX5622 (free base)/kg was added to OpenStandard Diet (OSD) with 15 kcal% fat
TR:TREATMENT_SUMMARY             	(Research diets, INC., New Brunswick, NJ, USA). Control mice were fed with OSD,
TR:TREATMENT_SUMMARY             	and experimental mice with OSD+ PLX5622 from 6 weeks of age until 8 weeks when
TR:TREATMENT_SUMMARY             	tissues were harvested.
#SAMPLEPREP
SP:SAMPLEPREP_SUMMARY            	Lipid extraction from the homogenates, standardized by protein content, employed
SP:SAMPLEPREP_SUMMARY            	a modified Bligh and Dyer procedure with added internal standards. Lipid
SP:SAMPLEPREP_SUMMARY            	quantification was achieved using triple-quadrupole and orbitrap mass
SP:SAMPLEPREP_SUMMARY            	spectrometers (Thermo Fisher Scientific, Waltham, MA, USA), both coupled with a
SP:SAMPLEPREP_SUMMARY            	Nanomate device (Advion, Ithaca, NY, USA) and controlled by the Xcalibur system.
SP:SAMPLEPREP_SUMMARY            	Data processing, including ion peak selection, baseline correction, data
SP:SAMPLEPREP_SUMMARY            	transfer, peak intensity comparison 13C deisotoping, and quantitation, was
SP:SAMPLEPREP_SUMMARY            	facilitated by a custom-programmed Microsoft Excel macro as previously
SP:SAMPLEPREP_SUMMARY            	described, ensuring accurate analysis of lipid molecular species.
#CHROMATOGRAPHY
CH:CHROMATOGRAPHY_TYPE           	None (Direct infusion)
CH:INSTRUMENT_NAME               	none
CH:COLUMN_NAME                   	none
CH:SOLVENT_A                     	none
CH:SOLVENT_B                     	none
CH:FLOW_GRADIENT                 	none
CH:FLOW_RATE                     	none
CH:COLUMN_TEMPERATURE            	none
#ANALYSIS
AN:ANALYSIS_TYPE                 	MS
#MS
MS:INSTRUMENT_NAME               	Thermo TSQ Altis
MS:INSTRUMENT_TYPE               	Triple quadrupole
MS:MS_TYPE                       	ESI
MS:ION_MODE                      	NEGATIVE
MS:MS_COMMENTS                   	For the measurements of PE, Cer.
#MS_METABOLITE_DATA
MS_METABOLITE_DATA:UNITS	nmol/mg protein
MS_METABOLITE_DATA_START
Samples	H_Control-1	H_Control-2	H_Control-3	H_Control-4	H_Control-5	H_Control-6	H_Control-7	H_Control-8	H_Control-9	H_Control-10	H_AD-1	H_AD-2	H_AD-3	H_AD-4	H_AD-5	H_AD-6	H_AD-7	H_AD-8	H_AD-9	H_AD-10	G_Non-Tg-1	G_Non-Tg-2	G_Non-Tg-3	G_Non-Tg-4	G_Non-Tg-5	G_Non-Tg-6	G_Non-Tg-7	G_Non-Tg-8	G_5xFAD-1	G_5xFAD-2	G_5xFAD-3	G_5xFAD-4	G_5xFAD-5	G_5xFAD-6	G_5xFAD-7	G_5xFAD-8	G_FIRE-1	G_FIRE-2	G_FIRE-3	G_FIRE-4	G_FIRE-5	G_FIRE-6	G_FIRE-7	G_5xFIRE-1	G_5xFIRE-2	G_5xFIRE-3	G_5xFIRE-4	G_5xFIRE-5	LP_Non-Tg-1	LP_Non-Tg-2	LP_Non-Tg-3	LP_Non-Tg-4	LP_Non-Tg-5	LP_5xFAD-1	LP_5xFAD-2	LP_5xFAD-3	LP_5xFAD-4	LP_5xFAD-5	LP_5xFAD-6	LP_5xFAD-7	LP_5xFAD-8	LP_5xFAD+PLX5622-1	LP_5xFAD+PLX5622-2	LP_5xFAD+PLX5622-3	LP_5xFAD+PLX5622-4	LP_5xFAD+PLX5622-5	LP_5xFAD+PLX5622-6	LP_5xFAD+PLX5622-7	LP_5xFAD+PLX5622-8	SP_Non-Tg-1	SP_Non-Tg-2	SP_Non-Tg-3	SP_Non-Tg-4	SP_Non-Tg-5	SP_Non-Tg-6	SP_Non-Tg-7	SP_Non-Tg-8	SP_Non-Tg-9	SP_Non-Tg-10	SP_5xFAD-1	SP_5xFAD-2	SP_5xFAD-3	SP_5xFAD-4	SP_5xFAD-5	SP_5xFAD-6	SP_5xFAD-7	SP_5xFAD-8	SP_5xFAD-9	SP_5xFAD-10	SP_Non-Tg+PLX5622-1	SP_Non-Tg+PLX5622-2	SP_Non-Tg+PLX5622-3	SP_Non-Tg+PLX5622-4	SP_Non-Tg+PLX5622-5	SP_Non-Tg+PLX5622-6	SP_Non-Tg+PLX5622-7	SP_Non-Tg+PLX5622-8	SP_Non-Tg+PLX5622-9	SP_5xFAD+PLX5622-1	SP_5xFAD+PLX5622-2	SP_5xFAD+PLX5622-3	SP_5xFAD+PLX5622-4	SP_5xFAD+PLX5622-5	SP_5xFAD+PLX5622-6	SP_5xFAD+PLX5622-7	SP_5xFAD+PLX5622-8	SP_5xFAD+PLX5622-9	SP_5xFAD+PLX5622-10
Factors	Subject_ID:Control | Treatment:/ | Subject Species:Human | Sex:Male | Sample source:Brodmann area 38	Subject_ID:Control | Treatment:/ | Subject Species:Human | Sex:Male | Sample source:Brodmann area 38	Subject_ID:Control | Treatment:/ | Subject Species:Human | Sex:Female | Sample source:Brodmann area 38	Subject_ID:Control | Treatment:/ | Subject Species:Human | Sex:Male | Sample source:Brodmann area 38	Subject_ID:Control | Treatment:/ | Subject Species:Human | Sex:Female | Sample source:Brodmann area 38	Subject_ID:Control | Treatment:/ | Subject Species:Human | Sex:Male | Sample source:Brodmann area 38	Subject_ID:Control | Treatment:/ | Subject Species:Human | Sex:Male | Sample source:Brodmann area 38	Subject_ID:Control | Treatment:/ | Subject Species:Human | Sex:Male | Sample source:Brodmann area 38	Subject_ID:Control | Treatment:/ | Subject Species:Human | Sex:Female | Sample source:Brodmann area 38	Subject_ID:Control | Treatment:/ | Subject Species:Human | Sex:Female | Sample source:Brodmann area 38	Subject_ID:AD | Treatment:/ | Subject Species:Human | Sex:Male | Sample source:Brodmann area 38	Subject_ID:AD | Treatment:/ | Subject Species:Human | Sex:Male | Sample source:Brodmann area 38	Subject_ID:AD | Treatment:/ | Subject Species:Human | Sex:Female | Sample source:Brodmann area 38	Subject_ID:AD | Treatment:/ | Subject Species:Human | Sex:Male | Sample source:Brodmann area 38	Subject_ID:AD | Treatment:/ | Subject Species:Human | Sex:Male | Sample source:Brodmann area 38	Subject_ID:AD | Treatment:/ | Subject Species:Human | Sex:Female | Sample source:Brodmann area 38	Subject_ID:AD | Treatment:/ | Subject Species:Human | Sex:Male | Sample source:Brodmann area 38	Subject_ID:AD | Treatment:/ | Subject Species:Human | Sex:Female | Sample source:Brodmann area 38	Subject_ID:AD | Treatment:/ | Subject Species:Human | Sex:Male | Sample source:Brodmann area 38	Subject_ID:AD | Treatment:/ | Subject Species:Human | Sex:Female | Sample source:Brodmann area 38	Subject_ID:Non-tansgenic | Treatment:OSD chow | Subject Species:Mus musculus | Sex:Female | Sample source:Cerebrum	Subject_ID:Non-tansgenic | Treatment:OSD chow | Subject Species:Mus musculus | Sex:Female | Sample source:Cerebrum	Subject_ID:Non-tansgenic | Treatment:OSD chow | Subject Species:Mus musculus | Sex:Female | Sample source:Cerebrum	Subject_ID:Non-tansgenic | Treatment:OSD chow | Subject Species:Mus musculus | Sex:Female | Sample source:Cerebrum	Subject_ID:Non-tansgenic | Treatment:OSD chow | Subject Species:Mus musculus | Sex:Male | Sample source:Cerebrum	Subject_ID:Non-tansgenic | Treatment:OSD chow | Subject Species:Mus musculus | Sex:Male | Sample source:Cerebrum	Subject_ID:Non-tansgenic | Treatment:OSD chow | Subject Species:Mus musculus | Sex:Male | Sample source:Cerebrum	Subject_ID:Non-tansgenic | Treatment:OSD chow | Subject Species:Mus musculus | Sex:Male | Sample source:Cerebrum	Subject_ID:5xFAD | Treatment:OSD chow | Subject Species:Mus musculus | Sex:Female | Sample source:Cerebrum	Subject_ID:5xFAD | Treatment:OSD chow | Subject Species:Mus musculus | Sex:Female | Sample source:Cerebrum	Subject_ID:5xFAD | Treatment:OSD chow | Subject Species:Mus musculus | Sex:Female | Sample source:Cerebrum	Subject_ID:5xFAD | Treatment:OSD chow | Subject Species:Mus musculus | Sex:Female | Sample source:Cerebrum	Subject_ID:5xFAD | Treatment:OSD chow | Subject Species:Mus musculus | Sex:Male | Sample source:Cerebrum	Subject_ID:5xFAD | Treatment:OSD chow | Subject Species:Mus musculus | Sex:Male | Sample source:Cerebrum	Subject_ID:5xFAD | Treatment:OSD chow | Subject Species:Mus musculus | Sex:Male | Sample source:Cerebrum	Subject_ID:5xFAD | Treatment:OSD chow | Subject Species:Mus musculus | Sex:Male | Sample source:Cerebrum	Subject_ID:FIRE | Treatment:OSD chow | Subject Species:Mus musculus | Sex:Female | Sample source:Cerebrum	Subject_ID:FIRE | Treatment:OSD chow | Subject Species:Mus musculus | Sex:Female | Sample source:Cerebrum	Subject_ID:FIRE | Treatment:OSD chow | Subject Species:Mus musculus | Sex:Female | Sample source:Cerebrum	Subject_ID:FIRE | Treatment:OSD chow | Subject Species:Mus musculus | Sex:Female | Sample source:Cerebrum	Subject_ID:FIRE | Treatment:OSD chow | Subject Species:Mus musculus | Sex:Male | Sample source:Cerebrum	Subject_ID:FIRE | Treatment:OSD chow | Subject Species:Mus musculus | Sex:Male | Sample source:Cerebrum	Subject_ID:FIRE | Treatment:OSD chow | Subject Species:Mus musculus | Sex:Male | Sample source:Cerebrum	Subject_ID:5xFIRE | Treatment:OSD chow | Subject Species:Mus musculus | Sex:Female | Sample source:Cerebrum	Subject_ID:5xFIRE | Treatment:OSD chow | Subject Species:Mus musculus | Sex:Female | Sample source:Cerebrum	Subject_ID:5xFIRE | Treatment:OSD chow | Subject Species:Mus musculus | Sex:Female | Sample source:Cerebrum	Subject_ID:5xFIRE | Treatment:OSD chow | Subject Species:Mus musculus | Sex:Male | Sample source:Cerebrum	Subject_ID:5xFIRE | Treatment:OSD chow | Subject Species:Mus musculus | Sex:Male | Sample source:Cerebrum	Subject_ID:Non-tansgenic | Treatment:OSD chow | Subject Species:Mus musculus | Sex:Female | Sample source:Cerebrum	Subject_ID:Non-tansgenic | Treatment:OSD chow | Subject Species:Mus musculus | Sex:Female | Sample source:Cerebrum	Subject_ID:Non-tansgenic | Treatment:OSD chow | Subject Species:Mus musculus | Sex:Female | Sample source:Cerebrum	Subject_ID:Non-tansgenic | Treatment:OSD chow | Subject Species:Mus musculus | Sex:Female | Sample source:Cerebrum	Subject_ID:Non-tansgenic | Treatment:OSD chow | Subject Species:Mus musculus | Sex:Female | Sample source:Cerebrum	Subject_ID:5xFAD | Treatment:OSD chow | Subject Species:Mus musculus | Sex:Female | Sample source:Cerebrum	Subject_ID:5xFAD | Treatment:OSD chow | Subject Species:Mus musculus | Sex:Female | Sample source:Cerebrum	Subject_ID:5xFAD | Treatment:OSD chow | Subject Species:Mus musculus | Sex:Female | Sample source:Cerebrum	Subject_ID:5xFAD | Treatment:OSD chow | Subject Species:Mus musculus | Sex:Female | Sample source:Cerebrum	Subject_ID:5xFAD | Treatment:OSD chow | Subject Species:Mus musculus | Sex:Female | Sample source:Cerebrum	Subject_ID:5xFAD | Treatment:OSD chow | Subject Species:Mus musculus | Sex:Female | Sample source:Cerebrum	Subject_ID:5xFAD | Treatment:OSD chow | Subject Species:Mus musculus | Sex:Female | Sample source:Cerebrum	Subject_ID:5xFAD | Treatment:OSD chow | Subject Species:Mus musculus | Sex:Female | Sample source:Cerebrum	Subject_ID:5xFAD | Treatment:PLX5622 | Subject Species:Mus musculus | Sex:Female | Sample source:Cerebrum	Subject_ID:5xFAD | Treatment:PLX5622 | Subject Species:Mus musculus | Sex:Female | Sample source:Cerebrum	Subject_ID:5xFAD | Treatment:PLX5622 | Subject Species:Mus musculus | Sex:Female | Sample source:Cerebrum	Subject_ID:5xFAD | Treatment:PLX5622 | Subject Species:Mus musculus | Sex:Female | Sample source:Cerebrum	Subject_ID:5xFAD | Treatment:PLX5622 | Subject Species:Mus musculus | Sex:Female | Sample source:Cerebrum	Subject_ID:5xFAD | Treatment:PLX5622 | Subject Species:Mus musculus | Sex:Female | Sample source:Cerebrum	Subject_ID:5xFAD | Treatment:PLX5622 | Subject Species:Mus musculus | Sex:Female | Sample source:Cerebrum	Subject_ID:5xFAD | Treatment:PLX5622 | Subject Species:Mus musculus | Sex:Female | Sample source:Cerebrum	Subject_ID:Non-tansgenic | Treatment:OSD chow | Subject Species:Mus musculus | Sex:Female | Sample source:Cerebrum	Subject_ID:Non-tansgenic | Treatment:OSD chow | Subject Species:Mus musculus | Sex:Female | Sample source:Cerebrum	Subject_ID:Non-tansgenic | Treatment:OSD chow | Subject Species:Mus musculus | Sex:Female | Sample source:Cerebrum	Subject_ID:Non-tansgenic | Treatment:OSD chow | Subject Species:Mus musculus | Sex:Female | Sample source:Cerebrum	Subject_ID:Non-tansgenic | Treatment:OSD chow | Subject Species:Mus musculus | Sex:Female | Sample source:Cerebrum	Subject_ID:Non-tansgenic | Treatment:OSD chow | Subject Species:Mus musculus | Sex:Female | Sample source:Cerebrum	Subject_ID:Non-tansgenic | Treatment:OSD chow | Subject Species:Mus musculus | Sex:Female | Sample source:Cerebrum	Subject_ID:Non-tansgenic | Treatment:OSD chow | Subject Species:Mus musculus | Sex:Female | Sample source:Cerebrum	Subject_ID:Non-tansgenic | Treatment:OSD chow | Subject Species:Mus musculus | Sex:Female | Sample source:Cerebrum	Subject_ID:Non-tansgenic | Treatment:OSD chow | Subject Species:Mus musculus | Sex:Female | Sample source:Cerebrum	Subject_ID:5xFAD | Treatment:OSD chow | Subject Species:Mus musculus | Sex:Female | Sample source:Cerebrum	Subject_ID:5xFAD | Treatment:OSD chow | Subject Species:Mus musculus | Sex:Female | Sample source:Cerebrum	Subject_ID:5xFAD | Treatment:OSD chow | Subject Species:Mus musculus | Sex:Female | Sample source:Cerebrum	Subject_ID:5xFAD | Treatment:OSD chow | Subject Species:Mus musculus | Sex:Female | Sample source:Cerebrum	Subject_ID:5xFAD | Treatment:OSD chow | Subject Species:Mus musculus | Sex:Female | Sample source:Cerebrum	Subject_ID:5xFAD | Treatment:OSD chow | Subject Species:Mus musculus | Sex:Female | Sample source:Cerebrum	Subject_ID:5xFAD | Treatment:OSD chow | Subject Species:Mus musculus | Sex:Female | Sample source:Cerebrum	Subject_ID:5xFAD | Treatment:OSD chow | Subject Species:Mus musculus | Sex:Female | Sample source:Cerebrum	Subject_ID:5xFAD | Treatment:OSD chow | Subject Species:Mus musculus | Sex:Female | Sample source:Cerebrum	Subject_ID:5xFAD | Treatment:OSD chow | Subject Species:Mus musculus | Sex:Female | Sample source:Cerebrum	Subject_ID:Non-tansgenic | Treatment:PLX5622 | Subject Species:Mus musculus | Sex:Female | Sample source:Cerebrum	Subject_ID:Non-tansgenic | Treatment:PLX5622 | Subject Species:Mus musculus | Sex:Female | Sample source:Cerebrum	Subject_ID:Non-tansgenic | Treatment:PLX5622 | Subject Species:Mus musculus | Sex:Female | Sample source:Cerebrum	Subject_ID:Non-tansgenic | Treatment:PLX5622 | Subject Species:Mus musculus | Sex:Female | Sample source:Cerebrum	Subject_ID:Non-tansgenic | Treatment:PLX5622 | Subject Species:Mus musculus | Sex:Female | Sample source:Cerebrum	Subject_ID:Non-tansgenic | Treatment:PLX5622 | Subject Species:Mus musculus | Sex:Female | Sample source:Cerebrum	Subject_ID:Non-tansgenic | Treatment:PLX5622 | Subject Species:Mus musculus | Sex:Female | Sample source:Cerebrum	Subject_ID:Non-tansgenic | Treatment:PLX5622 | Subject Species:Mus musculus | Sex:Female | Sample source:Cerebrum	Subject_ID:Non-tansgenic | Treatment:PLX5622 | Subject Species:Mus musculus | Sex:Female | Sample source:Cerebrum	Subject_ID:5xFAD | Treatment:PLX5622 | Subject Species:Mus musculus | Sex:Female | Sample source:Cerebrum	Subject_ID:5xFAD | Treatment:PLX5622 | Subject Species:Mus musculus | Sex:Female | Sample source:Cerebrum	Subject_ID:5xFAD | Treatment:PLX5622 | Subject Species:Mus musculus | Sex:Female | Sample source:Cerebrum	Subject_ID:5xFAD | Treatment:PLX5622 | Subject Species:Mus musculus | Sex:Female | Sample source:Cerebrum	Subject_ID:5xFAD | Treatment:PLX5622 | Subject Species:Mus musculus | Sex:Female | Sample source:Cerebrum	Subject_ID:5xFAD | Treatment:PLX5622 | Subject Species:Mus musculus | Sex:Female | Sample source:Cerebrum	Subject_ID:5xFAD | Treatment:PLX5622 | Subject Species:Mus musculus | Sex:Female | Sample source:Cerebrum	Subject_ID:5xFAD | Treatment:PLX5622 | Subject Species:Mus musculus | Sex:Female | Sample source:Cerebrum	Subject_ID:5xFAD | Treatment:PLX5622 | Subject Species:Mus musculus | Sex:Female | Sample source:Cerebrum	Subject_ID:5xFAD | Treatment:PLX5622 | Subject Species:Mus musculus | Sex:Female | Sample source:Cerebrum
Cer 18:1(4E);3OH/16:0	0.1934	0.183	0.1284	0.0929	0.1956	0.2631	0.2313	0.2178	0.1628	0.0887	0.2051	0.3169	0.1571	0.2521	0.137	0.2334	0.17	0.2561	0.1708	0.2113	0.0413	0.0235	0.0143	0.0287	0.0342	0.0289	0.0529	0.0393	0.0344	0.0402	0.0366	0.0893	0.038	0.0571	0.0628	0.0536	0.0163	0.0202	0.0359	0.0438	0.0641	0.059	0.0154	0.0548	0.1254	0.0433	0.0438	0.0339	0.0157	0.0233	0.0187	0.0261	0.0135	0.0178	0.0206	0.0116	0.0197	0.0159	0.0116	0.01	0.014	0.0206	0.0143	0.021	0.0097	0.0129	0.0189	0.0157	0.0244	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
Cer 18:1(4E);3OH/18:0	5.7107	4.9893	4.075	3.6401	5.5589	4.7376	5.1077	6.3739	4.7853	7.3131	5.7249	6.1573	4.3917	5.8728	6.6877	4.8812	7.1247	5.847	4.6852	5.1896	2.2017	2.1087	1.8146	2.1746	1.7314	2.2339	1.9483	2.6885	2.6053	2.0954	1.7161	2.1428	2.2433	2.5672	2.5139	2.3795	2.0894	2.1142	2.0488	2.0013	2.7078	2.3589	2.8637	3.2199	3.1037	2.1352	2.0686	2.3216	1.3737	1.4766	1.3074	1.413	1.2865	1.7797	1.7219	1.6125	1.4899	1.3815	1.4421	1.3363	1.5815	1.5076	1.3289	1.3615	1.3907	1.5103	1.5316	1.3753	1.5716	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
Cer 18:1(4E);3OH/20:0	0.318	0.27	0.1509	0.1702	0.2845	0.2451	0.4607	0.3753	0.2873	0.361	0.4299	0.3706	0.1763	0.3374	0.3411	0.3104	0.3836	0.3151	0.3187	0.3151	0.054	0.0432	0.0359	0.0326	0.0533	0.0528	0.0472	0.0805	0.0657	0.0574	0.0941	0.0483	0.0703	0.0793	0.0658	0.0692	0.075	0.0671	0.0842	0.0789	0.0554	0.0813	0.0675	0.1056	0.1083	0.0802	0.0473	0.0438	0.0304	0.0428	0.0372	0.0356	0.0322	0.0417	0.0407	0.0318	0.035	0.0393	0.038	0.0289	0.0348	0.0412	0.03	0.0391	0.0296	0.0384	0.038	0.0278	0.04	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
Cer 18:1(4E);3OH/24:0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	0.026	0.0236	0.0077	0.0479	0.04	0.0452	0.0539	0.0483	0.0586	0.0457	0.0683	0.0361	0.0437	0.05	0.0572	0.0571	0.021	0.0395	0.0429	0.0352	0.059	0.0332	0.0317	0.0695	0.0708	0.0678	0.0257	0.0319	0.0304	0.0214	0.0186	0.0234	0.0198	0.0232	0.0216	0.028	0.0226	0.0309	0.0152	0.016	0.0265	0.0206	0.0145	0.0227	0.0171	0.018	0.0197	0.0199	0.0217	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
Cer 18:1(4E);3OH/24:1(15Z)	1.8665	1.302	1.246	2.0536	1.6234	1.3376	1.747	0.7477	1.1368	0.5078	1.4963	2.4459	1.7803	1.51	0.1419	2.2299	1.1467	0.8707	0.9602	1.3157	0.3612	0.3249	0.2339	0.2802	0.3256	0.2341	0.2964	0.3293	0.3907	0.2333	0.4658	0.3546	0.2366	0.3927	0.3506	0.3955	0.2978	0.2587	0.1904	0.2876	0.3391	0.2782	0.4003	0.364	0.3155	0.3499	0.2088	0.2972	0.2294	0.2366	0.1937	0.2649	0.2113	0.1934	0.2702	0.217	0.2024	0.1884	0.1638	0.1228	0.2038	0.1884	0.1503	0.1894	0.132	0.1771	0.1867	0.1405	0.2047	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
Cer 18:1(4E);3OH/24:2(15Z,18Z);2OH	0.3462	0.2084	0.2193	0.3265	0.276	0.21	0.2453	0.1743	0.1493	0.1071	0.2977	0.3542	0.3024	0.2023	0.0199	0.382	0.1867	0.1719	0.1813	0.2464	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
Cer 18:1(4E);3OH/28:1(19Z)	0.9331	0.3469	0.3279	0.3765	0.2649	0.295	0.4139	0.2451	0.3058	0.137	0.3123	0.489	0.3095	0.489	0.0527	0.2714	0.3512	0.1423	0.3406	0.3668	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
Cer 18:1(4E);3OH/28:2(19Z,22Z)	2.6747	1.0405	1.0309	1.3358	0.9615	0.8452	2.2553	0.3997	1.0546	0.1987	1.1247	3.2714	1.775	1.5198	0.1728	1.3954	0.6047	0.6432	0.8484	1.5992	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
PE 16:0/18:1(9Z)	2.4585	2.5773	1.9168	4.591	2.0489	2.0424	3.0925	2.8284	2.6945	2.7564	2.3309	3.2533	2.695	3.1039	2.1239	2.0808	1.9581	2.8439	2.4012	2.6928	3.1084	4.4601	5.4121	5.3435	5.4423	5.5099	6.948	5.3503	2.3436	2.1125	3.2743	3.419	4.1551	4.2566	5.872	4.1163	6.4957	4.5743	4.0074	3.0799	3.1164	3.1498	2.3039	3.9105	3.4961	3.7105	3.3398	2.9267	4.7554	5.2083	6.5685	5.698	5.5152	8.6257	5.292	8.4504	6.876	4.676	5.714	5.932	5.9865	5.807	5.3736	6.8075	6.6214	6.9658	5.4964	5.4178	6.2122	3.2198	1.311	1.6851	1.309	1.7822	2.9301	2.3249	1.5288	2.0059	2.3707	1.5345	2.351	1.8117	1.692	1.7338	2.0366	1.4894	1.9446	1.6075	2.3214	1.4038	0.9653	1.3609	1.6216	1.348	1.8992	2.0572	2.1365	1.9838	1.2046	2.3117	0.9899	1.4943	1.9944	1.9197	1.3393	1.5868	1.2825	1.4088
PE 16:0/20:4(5Z,8Z,11Z,14Z)//18:2(9Z,12Z)/18:2(9Z,12Z)	1.6488	1.5451	1.5991	2.4169	1.2172	1.1276	1.662	1.9387	1.8771	1.5038	2.3314	1.902	1.6134	2.1902	2.0943	1.8907	2.0152	1.1938	1.3543	1.8893	2.1296	3.7698	2.9012	2.5871	3.4769	2.7329	2.9044	3.1593	4.861	4.085	3.8976	3.1145	2.5027	3.732	3.3512	3.2648	2.6407	2.7355	3.5695	3.7903	2.8672	2.7542	3.5911	3.064	4.1104	2.9955	2.9475	2.971	2.0349	2.6889	2.1345	2.1625	2.4464	2.7495	2.7238	3.1502	2.6154	2.1667	2.3278	2.4044	1.8224	2.4591	2.2777	2.4677	2.6402	2.5375	2.4855	2.2193	2.1058	2.6418	1.5975	1.8751	2.572	2.1892	2.9135	1.9863	1.8641	1.7955	2.0071	1.8347	2.0741	2.3962	2.0025	1.9324	1.7417	2.1101	2.2358	1.2298	2.3487	1.5755	1.702	1.3364	1.637	1.7172	1.8367	2.0819	2.2949	2.2184	2.1072	2.2846	1.5979	1.418	2.2784	1.8972	2.2132	1.9632	1.7049	1.6726
PE 16:0/22:6(4Z,7Z,10Z,13Z,16Z,19Z)	6.0104	6.9064	7.5133	6.663	5.3255	7.1019	6.4098	6.8333	6.7603	9.0379	7.5701	6.9698	7.127	7.4605	9.5636	7.9374	6.6951	7.0179	7.9347	7.7609	10.7598	12.7137	11.3221	12.8398	11.1322	11.2479	11.7256	11.6395	13.5508	9.2455	12.1446	11.1148	11.098	10.6863	13.6439	11.0667	11.8711	9.5719	12.9786	11.1652	11.2457	12.0909	14.3876	12.3425	14.7579	11.2413	11.5408	11.9238	8.4016	10.501	8.8442	10.3386	10.7405	10.8759	9.7407	10.3308	8.9664	9.0195	10.8391	8.751	8.9304	10.5254	8.5706	8.517	8.9597	10.1216	9.2948	8.3531	9.4102	8.9663	6.8533	6.3982	6.9567	8.0416	9.9854	7.9982	7.7968	7.7958	7.2069	7.3124	8.1702	6.3207	6.7506	6.5046	7.4108	7.1276	7.9529	6.6092	7.6972	6.3323	5.8175	6.4749	6.6591	6.6527	9.2295	7.4092	7.2842	7.203	5.6552	9.0225	6.7125	6.4419	8.259	7.4925	6.9219	7.6041	7.2539	5.9493
PE 18:0/18:1(9Z)//16:0/20:1(11Z)	3.4888	3.7564	3.2072	5.9896	2.3507	3.4041	3.9525	3.3257	4.0787	3.7438	3.3211	3.6972	3.0632	3.0951	2.2878	2.9483	2.6416	3.1824	3.3061	3.3067	3.4064	6.6929	5.0257	5.5498	5.944	5.1634	4.553	5.1087	3.1385	1.9742	5.9547	5.0111	3.8917	4.3349	5.5538	4.2275	5.7393	4.6562	4.5962	5.032	3.3872	2.9397	3.9225	3.2687	3.7902	3.8702	3.0071	3.3151	3.2491	2.8922	3.7007	3.9843	2.8377	3.8653	3.6572	3.6243	3.5285	2.2948	2.9483	2.4556	2.5534	3.2789	3.2797	3.0882	3.1114	3.8543	2.6835	3.0852	3.075	4.8296	2.7746	2.0264	2.315	2.0493	2.7987	3.0621	3.0643	3.2528	3.9101	1.8523	3.7573	2.0322	1.9864	1.5849	3.0898	2.5217	2.9905	2.4743	2.305	2.0078	2.1135	1.8317	2.0837	2.3203	2.2123	2.5043	2.8039	2.7648	1.7825	3.5157	1.8547	1.6496	1.8808	2.9195	1.8648	1.9346	2.4111	1.5785
PE 18:0/18:2(9Z,12Z)//18:1(9Z)/18:1(9Z)//16:0/20:2(11Z,14Z)	3.3696	3.079	3.8728	4.3657	2.7789	2.7527	4.1586	2.5946	3.6558	3.9739	4.2356	4.7831	4.5902	3.6122	2.6078	3.7654	3.4202	5.2578	2.8118	4.1216	4.6503	4.8015	4.6573	4.2853	5.7438	4.0986	3.7589	3.9404	3.4044	3.5501	6.2121	6.1802	5.2595	5.2908	4.4089	4.434	4.6205	4.5671	4.4204	4.7052	3.4563	4.1888	5.0261	3.6431	4.2826	4.3871	4.1257	4.4806	2.2463	3.1082	2.5027	3.2005	2.8405	2.904	3.1688	2.6516	2.7013	2.7199	2.9272	2.0862	2.4928	2.3089	2.652	2.3009	2.8712	2.7827	2.2297	2.6346	2.297	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
PE 18:0/20:4(5Z,8Z,11Z,14Z)//16:0/22:4(7Z,10Z,13Z,16Z)	25.3826	25.1904	27.1923	24.5079	20.9567	27.4564	25.9764	27.6732	27.332	33.3527	35.125	21.6407	17.844	25.0898	28.9068	26.8859	27.0467	23.3594	26.4752	30.0587	23.3352	28.0594	24.1506	26.9394	28.8021	28.8859	27.6898	26.4327	28.3449	29.8697	27.2368	24.2055	22.9166	29.4721	29.6545	21.1601	25.3035	27.0591	31.7739	29.573	24.9605	26.3907	26.9002	27.461	31.4789	23.1633	25.8766	29.7554	20.1985	23.375	23.1105	20.5292	20.7229	25.0598	23.008	23.5613	23.9646	22.0392	23.2572	21.1388	21.9046	22.7871	20.2362	19.9142	20.5274	21.54	20.4118	19.5145	22.9071	20.0396	15.8131	16.7062	19.3537	17.1201	23.0695	18.9946	18.2219	20.2516	17.61	17.0707	20.4607	16.1179	16.7407	16.1499	17.3036	17.5774	18.2789	16.0548	21.2355	14.4665	16.6845	15.3578	16.8837	15.8112	16.3691	18.5529	18.353	18.5731	15.1331	20.1048	15.7352	15.2353	17.8791	16.6955	17.5418	18.4014	16.435	16.8597
PE 18:0/22:6(4Z,7Z,10Z,13Z,16Z,19Z)//18:1(9Z)/22:5(4Z,7Z,10Z,13Z,16Z)	37.3515	43.0711	46.5664	37.5486	32.8156	47.535	36.5911	43.1017	38.769	59.8449	52.6592	29.827	35.7992	40.4047	46.5689	42.9383	36.895	33.9017	50.3449	43.3867	38.5157	45.4599	42.3758	38.0408	39.6852	47.399	49.5747	44.2306	39.834	45.7766	44.6811	40.706	40.9429	41.6538	45.3713	37.2357	45.5091	40.567	45.5227	39.2583	36.3489	39.4592	44.3177	36.6748	42.1159	38.0352	40.6508	38.4148	32.2422	37.8067	38.6202	37.2574	38.0171	46.1967	38.012	36.8519	34.4895	32.7857	36.4851	32.3231	35.5403	34.562	34.6742	32.1812	33.8683	35.9129	32.2385	32.2955	35.612	35.1854	25.3185	25.8165	32.7148	25.1377	34.4296	28.5635	28.2221	30.4247	26.6924	25.3895	29.8739	24.9397	24.0889	24.6703	30.3762	29.2113	27.9036	25.1666	29.5085	21.7166	24.7193	22.9444	24.5475	25.7595	26.2509	29.9267	28.6296	28.5212	21.3022	32.3369	21.338	20.5692	26.8061	26.8533	26.5604	27.1163	24.3238	22.97
PE 18:1(9Z)/20:4(5Z,8Z,11Z,14Z)//16:0/22:5 (4Z,7Z,10Z,13Z,16Z)	5.7254	5.3324	6.7885	7.0239	5.6416	5.5531	6.0085	6.0342	6.4615	7.1576	8.1202	8.3122	8.3623	6.8914	8.5604	7.715	6.7525	8.56	5.9063	7.3103	4.8774	5.3716	6.6882	5.9256	5.7249	6.4906	5.8081	5.6156	5.6543	7.0493	6.8467	7.138	5.8401	6.3704	6.3447	6.4968	5.6608	7.0293	6.4867	5.4869	5.6052	7.0312	7.8924	5.969	6.2118	5.9589	6.1809	5.4113	3.8689	5.0944	4.4888	4.3073	3.6111	5.9436	4.8558	5.6394	5.2124	5.0923	4.5325	3.79	4.3959	3.9108	3.4382	4.0253	3.6324	4.2325	4.3026	4.5336	3.9202	3.609	3.2143	3.2503	4.5294	2.9931	3.03	3.3983	3.4575	2.7592	3.391	3.097	3.5387	2.7307	2.8393	3.3985	3.7278	3.3577	3.4194	2.536	3.0794	2.5196	3.7303	2.9349	3.5612	3.7268	3.2343	3.7391	3.5347	2.5818	2.9252	3.6134	2.811	2.7443	2.9803	3.0006	3.0606	3.2929	3.2392	3.1621
PE 18:1(9Z)/22:6(4Z,7Z,10Z,13Z,16Z,19Z)	3.605	3.7287	4.5067	5.8007	3.3286	3.9001	3.5192	3.7819	3.6978	5.4936	4.8291	3.6615	5.5024	4.4884	5.2771	4.5686	4.0892	4.3657	3.8009	4.4143	5.0234	6.1704	6.2169	4.7355	7.2392	7.2722	8.1757	6.3219	6.4996	7.914	5.7924	4.9467	5.5551	5.7788	5.1703	5.5009	5.7965	4.8188	5.7332	6.2122	4.7439	5.1205	6.1865	4.6709	6.2139	6.2986	5.1615	5.6094	3.3338	4.0504	3.7573	4.491	3.4419	5.0272	4.0073	4.1957	3.4743	3.3577	4.1499	3.9479	4.0249	4.3534	2.7629	3.5324	3.5018	3.756	3.1516	3.5458	3.929	2.8703	3.1117	3.2531	4.1751	3.2935	4.4488	3.2412	3.7885	3.9106	2.8233	3.2276	3.0388	3.0654	2.5068	2.8245	3.1676	3.2229	3.8598	2.9563	3.7254	2.5532	2.8085	2.9233	2.8012	3.3149	2.9467	3.0986	4.7905	3.4477	2.5097	2.926	2.5312	2.4525	3.9602	2.4298	2.9894	3.4509	2.9283	2.8028
PE 20:0/20:4(5Z,8Z,11Z,14Z)//18:0/22:4(7Z,10Z,13Z,16Z)	10.2936	11.9124	13.4689	10.8295	9.296	15.2089	11.5861	12.7019	12.5092	14.0243	15.5366	7.2731	7.6355	10.5288	12.4197	12.8258	13.1019	8.6187	13.0687	12.749	4.152	6.3994	6.6682	5.8099	5.4154	7.2015	6.5429	7.3652	5.544	3.4728	5.2418	4.4596	3.8889	6.2157	6.6356	5.6783	7.5643	6.6452	5.3947	4.631	5.1899	4.8532	5.424	5.9026	5.5313	4.9436	4.0546	4.8807	3.5724	3.99	4.749	4.1057	4.2237	5.5881	4.2752	4.2602	4.0584	4.2408	4.6459	4.7676	3.8128	3.5429	3.7495	4.6249	3.083	4.7774	3.5127	4.0319	4.8186	3.5578	2.4116	3.3347	2.9622	3.3362	4.229	3.119	4.0827	3.824	3.1906	2.4453	2.9484	2.5516	2.3906	2.4168	3.6151	2.5885	3.7266	3.1278	3.2022	2.66	2.594	2.6953	3.2399	3.3165	3.5958	2.9925	3.3157	2.6982	2.4045	3.6673	2.3953	2.714	4.0926	3.0454	3.2017	3.0483	2.4923	3.8046
PE P-16:0/20:4(5Z,8Z,11Z,14Z)	2.6928	3.05	3.1655	2.3358	2.2042	3.6964	3.9083	3.5511	3.3645	3.5936	4.8039	3.4419	3.8078	3.3202	2.248	3.2701	3.1409	3.2873	2.9542	4.2683	3.8033	3.5742	3.9391	4.1223	4.106	5.7991	4.2859	5.1961	6.0802	4.8523	3.4324	3.2266	3.4627	4.0453	5.234	3.7722	4.3644	6.691	4.5806	3.9522	4.1702	4.6006	4.2141	3.8379	4.0287	3.0552	3.4626	4.8776	4.0719	4.1021	3.5273	4.4073	4.1921	3.8025	4.1163	4.4764	4.2861	3.4608	3.5697	3.1228	3.79	4.1514	4.5053	3.48	3.2558	4.78	3.5215	3.644	3.8703	5.5672	3.1594	2.5348	5.576	3.3394	5.0213	3.5287	3.3082	3.9401	6.0825	3.3191	4.9093	2.6545	3.6251	2.8545	3.6262	3.3086	3.7711	2.8658	3.6442	3.2544	3.2224	3.2634	3.2632	3.1556	3.0744	4.0771	3.6211	3.5686	3.2938	7.0347	3.0026	3.1822	3.2758	5.8418	4.0872	3.4516	3.7859	3.4502
PE P-16:0/22:6(4Z,7Z,10Z,13Z,16Z,19Z)//18:0/18:0//P-18:2(9Z,12Z)/20:4(5Z,8Z,11Z,14Z)	7.8747	9.1031	9.4042	6.5762	7.4007	8.1959	9.7329	7.7513	8.7974	12.278	10.0564	10.2239	9.119	10.268	11.2048	9.5587	8.5574	9.0028	9.9011	9.8878	17.9032	17.3612	15.7445	19.3833	14.5258	18.3533	22.5896	16.6765	20.4958	17.293	17.3903	17.079	15.4726	16.005	17.8999	14.7206	15.6289	15.7809	18.2553	19.5152	17.0967	20.7329	21.4832	21.787	19.895	17.8024	16.0547	18.608	12.7163	16.4721	15.9157	16.0195	15.7194	21.131	18.0733	17.4126	16.5994	13.8907	16.1815	14.9851	15.6719	15.4931	14.33	14.2521	16.063	16.3129	15.932	13.8889	16.7478	14.0613	10.3349	10.0307	13.7609	10.1073	11.6942	12.1638	11.7039	12.4771	11.3642	11.4181	12.3572	10.7364	10.4637	11.303	13.0046	12.6552	12.2054	9.9404	13.4281	9.7338	10.4296	9.5638	10.425	12.9327	11.4676	14.0737	12.0088	12.3536	9.7847	13.9667	9.4249	9.3571	11.4629	11.5983	11.2553	11.9001	11.1513	9.3163
PE P-18:0/18:1(9Z)//P-16:0/20:1(11Z)	4.8241	3.519	4.1173	6.3713	3.4968	4.3179	5.3089	2.7928	4.0025	4.3518	4.0459	6.0652	6.0346	4.0738	3.3113	5.277	3.125	5.3354	3.5589	4.461	7.1431	11.4569	12.9749	8.4463	13.417	12.9392	11.1151	11.0706	11.4022	9.3079	16.7924	12.6866	9.8838	8.5652	10.4156	11.2465	11.6583	10.9807	8.1384	10.7042	8.1286	7.3097	10.8234	7.0792	9.5165	8.0116	7.1727	7.1439	5.3874	5.6815	5.6009	5.4652	5.1382	7.5789	5.394	5.2142	4.8583	4.4814	5.1013	4.9331	5.2006	5.4348	4.6919	5.1384	4.4734	5.5078	5.0581	5.0565	4.4836	5.8484	4.3244	5.1641	9.959	6.3751	10.4025	7.3437	8.8588	8.6036	5.5187	4.4143	5.6243	5.2349	4.292	4.306	8.3254	6.8283	7.9835	9.0041	7.4626	4.3751	6.2746	4.3479	4.5813	6.0299	6.2894	6.3228	7.0134	8.1318	4.6672	6.0561	4.4043	3.9034	7.4505	5.0291	5.2813	6.0442	6.2538	5.4193
PE P-18:0/20:4(5Z,8Z,11Z,14Z)//P-16:0/22:4(7Z,10Z,13Z,16Z)//P-18:1(9Z)/20:3(8Z,11Z,14Z)	30.2251	32.5189	37.0194	29.3756	26.9369	38.1879	36.5938	32.1915	36.3882	34.8735	50.5484	33.8131	30.9873	30.5934	35.1891	40.697	34.5477	29.8989	36.9452	38.9306	15.5973	14.8209	19.4706	17.6374	18.8874	16.9419	16.9879	18.0299	18.0195	15.2731	18.0894	15.6481	14.9067	18.6863	17.7616	15.4982	17.791	16.5383	18.0167	18.717	15.5144	18.1783	15.7966	15.1336	17.4576	13.5812	16.6044	17.1502	13.9953	15.5129	16.5826	14.1629	15.1511	19.9259	16.6851	16.1588	15.1276	12.4231	15.4195	13.4327	13.4874	14.2877	13.3642	13.5887	13.5292	15.0177	13.2637	13.0746	13.2322	11.8654	8.3036	9.1309	13.2795	8.7508	12.5632	12.1916	11.7866	11.7154	9.7227	9.1294	10.2162	9.6464	9.0915	9.2828	12.4098	10.3729	12.0161	9.8168	11.5012	7.7083	8.3953	8.7271	9.609	10.9118	10.5601	11.3021	11.7097	11.3847	7.1828	11.1825	8.5548	7.9355	8.7153	9.2862	10.6357	11.5206	9.985	7.9682
PE P-18:0/22:4(7Z,10Z,13Z,16Z)//P-20:0/20:4(5Z,8Z,11Z,14Z)//P-18:1(9Z)/22:3(10Z,13Z,16Z)	19.0913	18.3087	21.943	18.714	16.7401	23.7197	21.0163	17.5437	23.149	22.1235	26.9234	20.5176	16.8679	17.6841	20.8201	24.1948	18.6269	16.0423	23.6722	21.4824	6.7009	9.9967	8.7804	7.6576	10.4021	7.8971	9.4161	9.0636	8.0255	10.9825	8.6687	6.5953	5.9462	8.0563	9.0506	7.524	10.1345	7.5663	9.4404	8.8876	7.3209	7.7079	7.4135	5.7394	7.5045	7.1599	6.9005	5.6735	5.3726	7.3535	6.1026	5.2542	6.4905	8.0068	5.9528	5.394	5.8843	5.3407	5.9297	6.6421	6.3036	5.6714	5.3467	5.5439	6.3806	6.6728	5.108	5.2569	5.1601	5.1013	3.5353	3.7304	4.7731	3.8538	4.6386	4.75	4.3592	4.0808	4.7763	3.31	3.5517	3.3898	3.389	3.3908	4.6872	4.0731	4.4916	3.8671	4.067	2.9327	2.9699	3.6171	3.6711	4.488	4.5796	4.2217	4.0492	4.4613	3.1502	3.7603	3.5245	2.7491	4.208	3.1226	3.6636	3.8839	4.4692	3.2729
PE P-18:0/22:5(4Z,7Z,10Z,13Z,16Z)//P-18:1(9Z)/22:4(7Z,10Z,13Z,16Z)	12.2567	12.8713	13.8097	20.4713	10.5437	14.2382	16.0347	9.5011	15.3138	11.2681	18.3331	19.8706	17.2884	11.6312	11.6058	20.6577	10.4913	12.6784	12.5888	14.0296	9.5805	8.4985	7.8158	9.5844	10.5273	10.2768	7.3871	9.0611	8.7145	6.9704	8.8036	9.1566	6.7116	9.7232	6.6341	7.559	8.6175	8.9576	7.5704	9.5675	6.983	9.4603	6.4711	5.933	7.4471	7.2629	5.5086	7.5593	5.8743	8.2347	7.5381	6.2363	7.5878	10.5302	6.2153	5.5933	5.0904	5.6181	5.7792	4.7801	5.479	6.0577	6.327	6.0168	5.6734	7.0249	5.4776	7.052	6.212	2.5476	1.8779	3.1673	5.3644	2.85	3.3844	3.3636	3.4419	3.29	2.1991	2.6998	2.9977	2.7324	2.6696	2.9578	3.6256	3.1177	3.0375	2.4297	3.3461	2.147	2.3463	2.4764	2.6913	3.5572	2.9801	3.2691	2.4247	3.2551	2.0357	2.2706	2.0833	2.4861	2.2237	1.8855	3.0595	4.4694	2.661	2.6116
PE P-18:0/22:6(4Z,7Z,10Z,13Z,16Z,19Z)//P-18:1(9Z)/22:5(4Z,7Z,10Z,13Z,16Z)//18:0/20:0	32.8265	34.5659	41.8023	33.8023	28.0453	39.3673	31.1708	34.2631	35.8389	47.7852	43.2081	36.4964	36.0099	34.6707	49.248	43.3394	33.5787	31.4216	46.0328	40.2223	28.2786	31.1491	31.0995	29.3773	32.6184	31.8913	31.657	32.1706	29.4597	30.4111	31.7557	30.6352	27.7419	29.0258	28.1249	25.1531	31.2746	28.4675	34.4139	35.825	29.1506	28.9893	33.3594	28.6774	31.8623	27.1444	29.5291	30.178	25.7358	29.5698	30.4613	28.6497	27.604	32.6814	28.8758	26.2683	24.301	21.3564	26.1979	23.0467	24.6432	23.1984	25.7176	21.1732	25.1768	22.9555	23.8353	23.8018	25.225	21.7688	12.6516	16.6301	18.0922	18.2548	22.4589	20.0715	19.9902	19.9974	17.8147	17.1624	20.9811	16.0458	15.2608	16.3232	20.8184	19.0235	20.5047	15.4251	20.7323	14.688	15.6527	15.4961	16.478	17.1823	18.9188	21.0178	20.9169	18.9828	14.639	19.2762	14.7852	13.7414	15.7826	16.0074	18.4609	19.321	17.2997	15.0375
PE P-18:1(9Z)/16:0//P-16:0/18:1(9Z)	4.8378	5.4755	5.8706	6.2469	3.7722	4.1779	7.6012	2.5269	4.4515	2.6278	5.6098	9.8924	9.6212	5.3776	4.0496	8.4747	2.6768	7.4571	3.2856	6.0717	3.5252	2.774	5.8744	2.9633	6.1477	3.8487	3.9105	3.6764	4.7277	3.5106	6.697	6.0108	3.8751	4.6035	3.9096	5.0532	4.683	4.3963	3.9157	4.5194	3.197	2.9622	3.7992	3.6857	4.5486	4.329	4.4938	3.9754	3.4567	3.482	3.5599	4.1192	2.792	5.051	3.5121	4.9231	3.3021	2.7315	2.8315	2.2114	3.9947	3.8015	3.6078	3.4221	3.1925	2.7732	2.5042	2.9554	3.8038	6.6748	2.2623	2.3392	3.2151	2.7218	3.9387	3.6486	3.9721	4.3439	4.6385	2.3703	4.8778	2.7323	2.9025	2.3323	3.8999	2.9816	3.9242	3.7056	3.9584	2.3597	3.1265	2.4211	2.756	3.2564	2.0319	3.2635	3.7436	3.4365	2.0333	5.7607	1.9773	2.3839	2.8542	4.7838	2.5993	2.3303	3.1993	2.5705
PE P-18:1(9Z)/18:1(9Z)//P-18:0/18:2(9Z,12Z)//P-16:0/20:2(11Z,14Z)	11.3489	11.8241	14.2302	15.4323	9.8466	10.2301	20.2233	4.3762	12.4992	5.3602	13.1504	23.7725	25.9007	12.1384	6.7007	19.8593	5.6955	13.5656	8.9726	13.207	12.4045	8.011	13.4101	8.846	14.3175	9.9427	9.5168	9.8966	12.0313	9.0219	18.0206	16.5223	14.788	13.7867	11.0791	10.9315	10.4151	9.6818	12.1918	14.63	12.232	10.2889	8.2135	11.2053	12.8494	11.6666	10.3711	12.0308	8.5323	8.1616	8.5571	9.5387	8.4525	10.6331	8.5608	9.7917	8.6757	7.2207	7.7265	7.5276	8.9974	8.4981	8.5963	9.012	9.0137	9.0002	8.63	7.8886	8.2399	5.7958	4.0784	4.0065	4.0782	4.6394	7.7274	5.9506	5.7908	6.8213	5.8888	4.2738	4.678	4.2648	4.3863	4.2165	6.2444	4.9523	5.9393	4.6108	5.9034	4.2847	3.5651	5.0233	4.7418	5.038	4.8249	5.0497	6.0007	5.3959	4.0855	4.6053	3.5925	4.2676	3.8649	3.8243	4.7108	4.9348	4.5242	3.9166
PE P-18:1(9Z)/20:0	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	2.0162	1.3848	3.6623	2.4231	5.0617	2.0845	2.233	2.5652	2.1537	2.991	5.2394	2.9892	2.6341	3.1265	3.0348	3.4594	3.5841	3.6371	2.1705	3.1493	1.7536	2.1253	2.4774	2.2079	1.466	2.5314	1.9624	3.11	1.5604	2.3966	2.6543	1.5889	1.9136	3.5494	1.8289	1.2703	1.8305	1.1689	1.7626	2.0193	1.74	2.1751	2.2254	1.8633	1.9791	1.6486	1.774	1.6414	1.3079	1.3782	1.0394	1.2397	1.4291	0.8005	1.9521	1.3895	1.4788	1.6783	1.1991	0.5205	0.6184	1.0123	0.7453	0.7438	1.3272	1.114	1.1797	1.0954	1.296	0.659	0.8341	0.9056	0.9503	1.6608	1.2354	0.9138	1.1028	1.5966	0.7247	1.2115	0.8344	0.7241	0.8728	1.0061	0.7562	0.6001	1.254	0.753
PE P-18:1(9Z)/20:4(5Z,8Z,11Z,14Z)//P-16:0/22:5(4Z,7Z,10Z,13Z,16Z)	11.8504	14.2854	15.3176	14.4687	10.5737	14.1275	17.7818	10.8685	14.9849	13.1007	19.7365	24.8926	20.7741	14.0109	13.7295	16.9576	11.6746	23.9289	11.8866	17.2135	9.1088	8.0714	8.2284	8.9635	10.4017	7.4986	9.0364	9.9262	10.1731	8.7298	12.0719	10.838	9.3429	11.2195	10.6738	7.548	9.117	10.8693	11.9646	11.8626	9.6941	9.1968	8.9669	8.7625	9.883	8.3623	10.1515	11.0355	8.0014	9.5592	8.5995	9.1056	8.5292	10.8311	10.0571	9.343	8.6901	7.6699	8.445	7.0747	7.658	7.9064	7.0769	7.6972	7.346	9.0947	8.1028	7.8998	8.7081	4.462	4.2556	4.9307	5.8668	4.87	5.4406	5.5989	5.2199	4.4288	3.744	4.3413	3.911	4.8869	5.1627	4.758	5.4175	5.5287	5.7494	3.5369	4.7183	3.983	4.6128	4.0214	5.0956	5.9834	5.2141	6.2141	5.2467	5.9682	4.077	5.3962	4.6237	4.2196	4.6515	4.4812	5.4015	4.7256	4.1031	3.8185
PE P-18:1(9Z)/22:6(4Z,7Z,10Z,13Z,16Z,19Z)//18:0/20:1(11Z)	6.3097	7.4396	7.7061	7.2611	5.7053	7.2818	6.9202	5.9736	7.5103	8.097	9.3624	9.7736	9.062	7.5697	8.7392	9.9242	5.4154	8.896	7.9021	7.6945	9.8508	13.3388	10.5139	11.7328	10.5452	11.3346	11.5582	10.919	9.665	9.9329	9.7986	9.8257	10.5697	9.7308	11.8944	9.5994	10.5859	10.987	12.164	12.0174	10.415	11.6591	11.7351	10.479	12.8306	8.769	10.9382	10.5051	9.2491	10.193	9.8751	11.1605	10.9386	12.3701	11.2947	11.6646	9.903	9.2557	9.9211	8.3181	9.2699	9.699	10.1622	8.7126	9.775	10.3643	9.5992	9.62	10.3991	5.4731	4.762	4.9152	5.8067	5.3336	7.708	6.6324	5.9215	6.2971	4.5558	5.4234	4.6476	5.1921	4.8323	5.5969	6.3025	5.8309	6.2887	4.5243	6.3767	4.6184	6.3997	5.1476	5.5797	6.6323	6.4577	5.6295	6.8214	6.056	4.5367	5.7576	4.521	4.9685	6.3493	4.7813	6.0093	6.8997	4.9233	5.1581
PE P-20:1(11Z)/18:1(9Z)//P-18:1(9Z)/20:1(11Z)	1.8279	1.9737	1.7309	4.4491	1.7805	1.451	2.4422	1.0666	2.044	1.4392	2.2295	3.638	4.2318	1.7411	1.1248	2.3902	1.1207	1.1898	1.4955	2.0556	4.7036	9.2243	7.4693	5.3457	8.5167	8.8573	5.8072	5.9944	6.5431	3.6623	8.4527	8.0896	4.4918	5.3569	4.9739	6.4096	7.4812	8.1117	4.2652	6.5103	4.5677	5.1686	4.1347	3.3993	3.7043	5.1055	3.5475	4.8514	3.681	3.8322	3.8164	4.5567	3.6718	4.512	4.0306	3.9117	3.2292	3.365	3.7902	3.1411	3.8061	3.5315	3.4587	4.1876	3.4338	3.8015	2.9694	3.1191	3.1205	2.2788	1.6446	1.9229	2.124	1.9151	3.2797	2.1361	2.8166	2.2864	2.1512	1.714	2.2245	1.5126	1.7687	1.6434	2.3039	1.7761	2.4683	2.0486	2.1094	1.5744	1.4632	1.8991	1.725	2.8483	2.2052	1.4487	2.3593	2.2026	1.1214	1.5694	1.7148	1.5796	0.9244	1.3033	1.3829	1.8603	1.7807	1.5062
MS_METABOLITE_DATA_END
#METABOLITES
METABOLITES_START
metabolite_name	Lipid
Cer 18:1(4E);3OH/16:0	Ceramide
Cer 18:1(4E);3OH/18:0	Ceramide
Cer 18:1(4E);3OH/20:0	Ceramide
Cer 18:1(4E);3OH/24:0	Ceramide
Cer 18:1(4E);3OH/24:1(15Z)	Ceramide
Cer 18:1(4E);3OH/24:2(15Z,18Z);2OH	Ceramide
Cer 18:1(4E);3OH/28:1(19Z)	Ceramide
Cer 18:1(4E);3OH/28:2(19Z,22Z)	Ceramide
PE 16:0/18:1(9Z)	Phosphatidylethanolamine
PE 16:0/20:4(5Z,8Z,11Z,14Z)//18:2(9Z,12Z)/18:2(9Z,12Z)	Phosphatidylethanolamine
PE 16:0/22:6(4Z,7Z,10Z,13Z,16Z,19Z)	Phosphatidylethanolamine
PE 18:0/18:1(9Z)//16:0/20:1(11Z)	Phosphatidylethanolamine
PE 18:0/18:2(9Z,12Z)//18:1(9Z)/18:1(9Z)//16:0/20:2(11Z,14Z)	Phosphatidylethanolamine
PE 18:0/20:4(5Z,8Z,11Z,14Z)//16:0/22:4(7Z,10Z,13Z,16Z)	Phosphatidylethanolamine
PE 18:0/22:6(4Z,7Z,10Z,13Z,16Z,19Z)//18:1(9Z)/22:5(4Z,7Z,10Z,13Z,16Z)	Phosphatidylethanolamine
PE 18:1(9Z)/20:4(5Z,8Z,11Z,14Z)//16:0/22:5 (4Z,7Z,10Z,13Z,16Z)	Phosphatidylethanolamine
PE 18:1(9Z)/22:6(4Z,7Z,10Z,13Z,16Z,19Z)	Phosphatidylethanolamine
PE 20:0/20:4(5Z,8Z,11Z,14Z)//18:0/22:4(7Z,10Z,13Z,16Z)	Phosphatidylethanolamine
PE P-16:0/20:4(5Z,8Z,11Z,14Z)	Phosphatidylethanolamine
PE P-16:0/22:6(4Z,7Z,10Z,13Z,16Z,19Z)//18:0/18:0//P-18:2(9Z,12Z)/20:4(5Z,8Z,11Z,14Z)	Phosphatidylethanolamine
PE P-18:0/18:1(9Z)//P-16:0/20:1(11Z)	Phosphatidylethanolamine
PE P-18:0/20:4(5Z,8Z,11Z,14Z)//P-16:0/22:4(7Z,10Z,13Z,16Z)//P-18:1(9Z)/20:3(8Z,11Z,14Z)	Phosphatidylethanolamine
PE P-18:0/22:4(7Z,10Z,13Z,16Z)//P-20:0/20:4(5Z,8Z,11Z,14Z)//P-18:1(9Z)/22:3(10Z,13Z,16Z)	Phosphatidylethanolamine
PE P-18:0/22:5(4Z,7Z,10Z,13Z,16Z)//P-18:1(9Z)/22:4(7Z,10Z,13Z,16Z)	Phosphatidylethanolamine
PE P-18:0/22:6(4Z,7Z,10Z,13Z,16Z,19Z)//P-18:1(9Z)/22:5(4Z,7Z,10Z,13Z,16Z)//18:0/20:0	Phosphatidylethanolamine
PE P-18:1(9Z)/16:0//P-16:0/18:1(9Z)	Phosphatidylethanolamine
PE P-18:1(9Z)/18:1(9Z)//P-18:0/18:2(9Z,12Z)//P-16:0/20:2(11Z,14Z)	Phosphatidylethanolamine
PE P-18:1(9Z)/20:0	Phosphatidylethanolamine
PE P-18:1(9Z)/20:4(5Z,8Z,11Z,14Z)//P-16:0/22:5(4Z,7Z,10Z,13Z,16Z)	Phosphatidylethanolamine
PE P-18:1(9Z)/22:6(4Z,7Z,10Z,13Z,16Z,19Z)//18:0/20:1(11Z)	Phosphatidylethanolamine
PE P-20:1(11Z)/18:1(9Z)//P-18:1(9Z)/20:1(11Z)	Phosphatidylethanolamine
METABOLITES_END
#END