#METABOLOMICS WORKBENCH Jung_DNLI_20250707_104749 DATATRACK_ID:6141 STUDY_ID:ST004059 ANALYSIS_ID:AN006712 PROJECT_ID:PR002548 VERSION 1 CREATED_ON July 22, 2025, 11:13 am #PROJECT PR:PROJECT_TITLE Lysosomal polyamine storage upon ATP13A2 loss impairs β-glucocerebrosidase via PR:PROJECT_TITLE altered lysosomal pH and electrostatic hydrolase-lipid interactions PR:PROJECT_TYPE Preclinical Mouse and cellular studies PR:PROJECT_SUMMARY ATP13A2 is an endolysosomal polyamine transporter mutated in several PR:PROJECT_SUMMARY neurodegenerative conditions involving lysosomal defects, including PR:PROJECT_SUMMARY Parkinson’s disease (PD). While polyamines are polybasic and polycationic PR:PROJECT_SUMMARY molecules that play pleiotropic cellular roles, their specific impact on PR:PROJECT_SUMMARY lysosomal health is unknown. Here, we demonstrate lysosomal polyamine PR:PROJECT_SUMMARY accumulation in ATP13A2 knockout (KO) cell lines. Primary polyamine storage PR:PROJECT_SUMMARY caused secondary storage of lysosomal anionic phospholipid PR:PROJECT_SUMMARY bis(monoacylglycero)phosphate (BMP) and age-dependent increase in the PR:PROJECT_SUMMARY β-glucocerebrosidase (GCase) substrate, glucosylsphingosine, in Atp13a2 KO PR:PROJECT_SUMMARY brains. Polyamine accumulation inhibited lysosomal GCase activity in cells and PR:PROJECT_SUMMARY this was reversed by lysosome reacidification or BMP supplementation. A PR:PROJECT_SUMMARY liposome-based GCase assay utilizing physiological substrates demonstrated PR:PROJECT_SUMMARY dose-dependent inhibition of BMP-stimulated GCase activity by polyamines, in PR:PROJECT_SUMMARY part via a pH-independent, electrostatics-based mechanism. Therefore, excess PR:PROJECT_SUMMARY polyamine compromises lysosomes by disrupting pH and electrostatic interactions PR:PROJECT_SUMMARY between GCase and BMP enabling efficient substrate hydrolysis, potentially PR:PROJECT_SUMMARY clarifying their pathogenic mechanisms, and suggesting convergence on PR:PROJECT_SUMMARY PD-relevant pathways. PR:INSTITUTE Denali Therapeutics PR:LAST_NAME Suh PR:FIRST_NAME Jung PR:ADDRESS 161 Oyster Point Blvd, South San Francisco, California, 94080, USA PR:EMAIL suh@dnli.com PR:PHONE +1 06507973837 #STUDY ST:STUDY_TITLE Targeted Lipid and Metabolite Profiling in Brains of ATP13A2 Knockout Mice ST:STUDY_SUMMARY Comprehensive targeted profiling of lipids and metabolites was conducted in ST:STUDY_SUMMARY brain tissues from ATP13A2 knockout mice at 4.5 and 15 months of age to assess ST:STUDY_SUMMARY ATP13A2 deletion and its association with lysosomal dysfunction. ST:INSTITUTE Denali Therapeutics ST:LAST_NAME Suh ST:FIRST_NAME Jung ST:ADDRESS 161 Oyster Point Blvd, South San Francisco, California, 94080, USA ST:EMAIL suh@dnli.com ST:PHONE +1 06507973837 #SUBJECT SU:SUBJECT_TYPE Mammal SU:SUBJECT_SPECIES Mus musculus SU:TAXONOMY_ID 10090 #SUBJECT_SAMPLE_FACTORS: SUBJECT(optional)[tab]SAMPLE[tab]FACTORS(NAME:VALUE pairs separated by |)[tab]Raw file names and additional sample data SUBJECT_SAMPLE_FACTORS Pool_Cortex_001 HSA-000038800 genotype:WT | Sample source:brain sex=NA; age=15; age_unit=month; region=Cortex; RAW_FILE_NAME(Raw Source Name.PITC)=20240607_MS_HEX-000817_PITC_Pos-20240607_MS_HEX-000817_Cortex_PITC_Pos_001.mzML; RAW_FILE_NAME(Raw Source Name.LP)=20240521_MS_HEX-000817_Lipid_Pos_001.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20240524_MS_HEX-000817_Lipid_Neg_001.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20240523_MS_HEX-000817_Met_Pos_001.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20240524_MS_HEX-000817_Met_Neg_001.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20240522_MS_HEX-000817_HALO_Pos_001.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20240528_MS_HEX-000817_GM_Neg_001.mzML SUBJECT_SAMPLE_FACTORS Cortex_13 HSA-000038799 genotype:HOM KO ATP13A2 | Sample source:brain sex=Male; age=15; age_unit=month; region=Cortex; RAW_FILE_NAME(Raw Source Name.PITC)=20240607_MS_HEX-000817_PITC_Pos-20240607_MS_HEX-000817_Cortex_PITC_Pos_002.mzML; RAW_FILE_NAME(Raw Source Name.LP)=20240521_MS_HEX-000817_Lipid_Pos_002.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20240524_MS_HEX-000817_Lipid_Neg_002.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20240523_MS_HEX-000817_Met_Pos_002.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20240524_MS_HEX-000817_Met_Neg_002.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20240522_MS_HEX-000817_HALO_Pos_002.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20240528_MS_HEX-000817_GM_Neg_002.mzML SUBJECT_SAMPLE_FACTORS Cortex_08 HSA-000038794 genotype:HOM KO ATP13A2 | Sample source:brain sex=Female; age=15; age_unit=month; region=Cortex; RAW_FILE_NAME(Raw Source Name.PITC)=20240607_MS_HEX-000817_PITC_Pos-20240607_MS_HEX-000817_Cortex_PITC_Pos_003.mzML; RAW_FILE_NAME(Raw Source Name.LP)=20240521_MS_HEX-000817_Lipid_Pos_003.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20240524_MS_HEX-000817_Lipid_Neg_003.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20240523_MS_HEX-000817_Met_Pos_003.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20240524_MS_HEX-000817_Met_Neg_003.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20240522_MS_HEX-000817_HALO_Pos_003.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20240528_MS_HEX-000817_GM_Neg_003.mzML SUBJECT_SAMPLE_FACTORS Cortex_02 HSA-000038788 genotype:WT | Sample source:brain sex=Male; age=15; age_unit=month; region=Cortex; RAW_FILE_NAME(Raw Source Name.PITC)=20240607_MS_HEX-000817_PITC_Pos-20240607_MS_HEX-000817_Cortex_PITC_Pos_004.mzML; RAW_FILE_NAME(Raw Source Name.LP)=20240521_MS_HEX-000817_Lipid_Pos_004.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20240524_MS_HEX-000817_Lipid_Neg_004.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20240523_MS_HEX-000817_Met_Pos_004.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20240524_MS_HEX-000817_Met_Neg_004.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20240522_MS_HEX-000817_HALO_Pos_004.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20240528_MS_HEX-000817_GM_Neg_004.mzML SUBJECT_SAMPLE_FACTORS Cortex_11 HSA-000038797 genotype:HOM KO ATP13A2 | Sample source:brain sex=Male; age=15; age_unit=month; region=Cortex; RAW_FILE_NAME(Raw Source Name.PITC)=20240607_MS_HEX-000817_PITC_Pos-20240607_MS_HEX-000817_Cortex_PITC_Pos_005.mzML; RAW_FILE_NAME(Raw Source Name.LP)=20240521_MS_HEX-000817_Lipid_Pos_005.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20240524_MS_HEX-000817_Lipid_Neg_005.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20240523_MS_HEX-000817_Met_Pos_005.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20240524_MS_HEX-000817_Met_Neg_005.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20240522_MS_HEX-000817_HALO_Pos_005.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20240528_MS_HEX-000817_GM_Neg_005.mzML SUBJECT_SAMPLE_FACTORS Cortex_04 HSA-000038790 genotype:HOM KO ATP13A2 | Sample source:brain sex=Male; age=15; age_unit=month; region=Cortex; RAW_FILE_NAME(Raw Source Name.PITC)=20240607_MS_HEX-000817_PITC_Pos-20240607_MS_HEX-000817_Cortex_PITC_Pos_006.mzML; RAW_FILE_NAME(Raw Source Name.LP)=20240521_MS_HEX-000817_Lipid_Pos_006.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20240524_MS_HEX-000817_Lipid_Neg_006.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20240523_MS_HEX-000817_Met_Pos_006.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20240524_MS_HEX-000817_Met_Neg_006.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20240522_MS_HEX-000817_HALO_Pos_006.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20240528_MS_HEX-000817_GM_Neg_006.mzML SUBJECT_SAMPLE_FACTORS Cortex_12 HSA-000038798 genotype:WT | Sample source:brain sex=Female; age=15; age_unit=month; region=Cortex; RAW_FILE_NAME(Raw Source Name.PITC)=20240607_MS_HEX-000817_PITC_Pos-20240607_MS_HEX-000817_Cortex_PITC_Pos_007.mzML; RAW_FILE_NAME(Raw Source Name.LP)=20240521_MS_HEX-000817_Lipid_Pos_007.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20240524_MS_HEX-000817_Lipid_Neg_007.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20240523_MS_HEX-000817_Met_Pos_007.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20240524_MS_HEX-000817_Met_Neg_007.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20240522_MS_HEX-000817_HALO_Pos_007.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20240528_MS_HEX-000817_GM_Neg_007.mzML SUBJECT_SAMPLE_FACTORS Cortex_09 HSA-000038795 genotype:NA | Sample source:brain sex=Male; age=15; age_unit=month; region=Cortex; RAW_FILE_NAME(Raw Source Name.PITC)=20240607_MS_HEX-000817_PITC_Pos-20240607_MS_HEX-000817_Cortex_PITC_Pos_008.mzML; RAW_FILE_NAME(Raw Source Name.LP)=20240521_MS_HEX-000817_Lipid_Pos_008.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20240524_MS_HEX-000817_Lipid_Neg_008.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20240523_MS_HEX-000817_Met_Pos_008.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20240524_MS_HEX-000817_Met_Neg_008.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20240522_MS_HEX-000817_HALO_Pos_008.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20240528_MS_HEX-000817_GM_Neg_008.mzML SUBJECT_SAMPLE_FACTORS Pool_Cortex_002 HSA-000039091 genotype:HOM KO ATP13A2 | Sample source:brain sex=NA; age=15; age_unit=month; region=Cortex; RAW_FILE_NAME(Raw Source Name.PITC)=20240607_MS_HEX-000817_PITC_Pos-20240607_MS_HEX-000817_Cortex_PITC_Pos_009.mzML; RAW_FILE_NAME(Raw Source Name.LP)=20240521_MS_HEX-000817_Lipid_Pos_009.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20240524_MS_HEX-000817_Lipid_Neg_009.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20240523_MS_HEX-000817_Met_Pos_009.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20240524_MS_HEX-000817_Met_Neg_009.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20240522_MS_HEX-000817_HALO_Pos_009.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20240528_MS_HEX-000817_GM_Neg_009.mzML SUBJECT_SAMPLE_FACTORS Cortex_10 HSA-000038796 genotype:WT | Sample source:brain sex=Female; age=15; age_unit=month; region=Cortex; RAW_FILE_NAME(Raw Source Name.PITC)=20240607_MS_HEX-000817_PITC_Pos-20240607_MS_HEX-000817_Cortex_PITC_Pos_010.mzML; RAW_FILE_NAME(Raw Source Name.LP)=20240521_MS_HEX-000817_Lipid_Pos_010.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20240524_MS_HEX-000817_Lipid_Neg_010.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20240523_MS_HEX-000817_Met_Pos_010.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20240524_MS_HEX-000817_Met_Neg_010.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20240522_MS_HEX-000817_HALO_Pos_010.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20240528_MS_HEX-000817_GM_Neg_010.mzML SUBJECT_SAMPLE_FACTORS Cortex_05 HSA-000038791 genotype:WT | Sample source:brain sex=Female; age=15; age_unit=month; region=Cortex; RAW_FILE_NAME(Raw Source Name.PITC)=20240607_MS_HEX-000817_PITC_Pos-20240607_MS_HEX-000817_Cortex_PITC_Pos_011.mzML; RAW_FILE_NAME(Raw Source Name.LP)=20240521_MS_HEX-000817_Lipid_Pos_011.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20240524_MS_HEX-000817_Lipid_Neg_011.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20240523_MS_HEX-000817_Met_Pos_011.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20240524_MS_HEX-000817_Met_Neg_011.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20240522_MS_HEX-000817_HALO_Pos_011.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20240528_MS_HEX-000817_GM_Neg_011.mzML SUBJECT_SAMPLE_FACTORS Cortex_01 HSA-000038787 genotype:HOM KO ATP13A2 | Sample source:brain sex=Female; age=15; age_unit=month; region=Cortex; RAW_FILE_NAME(Raw Source Name.PITC)=20240607_MS_HEX-000817_PITC_Pos-20240607_MS_HEX-000817_Cortex_PITC_Pos_012.mzML; RAW_FILE_NAME(Raw Source Name.LP)=20240521_MS_HEX-000817_Lipid_Pos_012.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20240524_MS_HEX-000817_Lipid_Neg_012.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20240523_MS_HEX-000817_Met_Pos_012.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20240524_MS_HEX-000817_Met_Neg_012.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20240522_MS_HEX-000817_HALO_Pos_012.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20240528_MS_HEX-000817_GM_Neg_012.mzML SUBJECT_SAMPLE_FACTORS Cortex_06 HSA-000038792 genotype:WT | Sample source:brain sex=Male; age=15; age_unit=month; region=Cortex; RAW_FILE_NAME(Raw Source Name.PITC)=20240607_MS_HEX-000817_PITC_Pos-20240607_MS_HEX-000817_Cortex_PITC_Pos_013.mzML; RAW_FILE_NAME(Raw Source Name.LP)=20240521_MS_HEX-000817_Lipid_Pos_013.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20240524_MS_HEX-000817_Lipid_Neg_013.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20240523_MS_HEX-000817_Met_Pos_013.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20240524_MS_HEX-000817_Met_Neg_013.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20240522_MS_HEX-000817_HALO_Pos_013.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20240528_MS_HEX-000817_GM_Neg_013.mzML SUBJECT_SAMPLE_FACTORS Cortex_07 HSA-000038793 genotype:WT | Sample source:brain sex=Male; age=15; age_unit=month; region=Cortex; RAW_FILE_NAME(Raw Source Name.PITC)=20240607_MS_HEX-000817_PITC_Pos-20240607_MS_HEX-000817_Cortex_PITC_Pos_014.mzML; RAW_FILE_NAME(Raw Source Name.LP)=20240521_MS_HEX-000817_Lipid_Pos_014.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20240524_MS_HEX-000817_Lipid_Neg_014.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20240523_MS_HEX-000817_Met_Pos_014.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20240524_MS_HEX-000817_Met_Neg_014.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20240522_MS_HEX-000817_HALO_Pos_014.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20240528_MS_HEX-000817_GM_Neg_014.mzML SUBJECT_SAMPLE_FACTORS Cortex_03 HSA-000038789 genotype:NA | Sample source:brain sex=Female; age=15; age_unit=month; region=Cortex; RAW_FILE_NAME(Raw Source Name.PITC)=20240607_MS_HEX-000817_PITC_Pos-20240607_MS_HEX-000817_Cortex_PITC_Pos_015.mzML; RAW_FILE_NAME(Raw Source Name.LP)=20240521_MS_HEX-000817_Lipid_Pos_015.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20240524_MS_HEX-000817_Lipid_Neg_015.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20240523_MS_HEX-000817_Met_Pos_015.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20240524_MS_HEX-000817_Met_Neg_015.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20240522_MS_HEX-000817_HALO_Pos_015.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20240528_MS_HEX-000817_GM_Neg_015.mzML SUBJECT_SAMPLE_FACTORS Pool_Cortex_003 HSA-000039092 genotype:NA | Sample source:brain sex=NA; age=15; age_unit=month; region=Cortex; RAW_FILE_NAME(Raw Source Name.PITC)=20240607_MS_HEX-000817_PITC_Pos-20240607_MS_HEX-000817_Cortex_PITC_Pos_016.mzML; RAW_FILE_NAME(Raw Source Name.LP)=20240521_MS_HEX-000817_Lipid_Pos_016.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20240524_MS_HEX-000817_Lipid_Neg_016.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20240523_MS_HEX-000817_Met_Pos_016.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20240524_MS_HEX-000817_Met_Neg_016.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20240522_MS_HEX-000817_HALO_Pos_016.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20240528_MS_HEX-000817_GM_Neg_016.mzML SUBJECT_SAMPLE_FACTORS Pool_Hippo_001 HSA-000038814 genotype:WT | Sample source:brain sex=NA; age=15; age_unit=month; region=Hippocampus; RAW_FILE_NAME(Raw Source Name.PITC)=20240607_MS_HEX-000817_PITC_Pos-20240607_MS_HEX-000817_HippC_PITC_Pos_002; RAW_FILE_NAME(Raw Source Name.LP)=20240521_MS_HEX-000817_Lipid_Pos_017.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20240524_MS_HEX-000817_Lipid_Neg_017.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20240523_MS_HEX-000817_Met_Pos_017.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20240524_MS_HEX-000817_Met_Neg_017.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20240522_MS_HEX-000817_HALO_Pos_017.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20240528_MS_HEX-000817_GM_Neg_017.mzML SUBJECT_SAMPLE_FACTORS Hipp_13 HSA-000038813 genotype:WT | Sample source:brain sex=Male; age=15; age_unit=month; region=Hippocampus; RAW_FILE_NAME(Raw Source Name.PITC)=20240607_MS_HEX-000817_PITC_Pos-20240607_MS_HEX-000817_HippC_PITC_Pos_003; RAW_FILE_NAME(Raw Source Name.LP)=20240521_MS_HEX-000817_Lipid_Pos_018.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20240524_MS_HEX-000817_Lipid_Neg_018.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20240523_MS_HEX-000817_Met_Pos_018.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20240524_MS_HEX-000817_Met_Neg_018.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20240522_MS_HEX-000817_HALO_Pos_018.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20240528_MS_HEX-000817_GM_Neg_018.mzML SUBJECT_SAMPLE_FACTORS Hipp_11 HSA-000038811 genotype:HOM KO ATP13A2 | Sample source:brain sex=Male; age=15; age_unit=month; region=Hippocampus; RAW_FILE_NAME(Raw Source Name.PITC)=20240607_MS_HEX-000817_PITC_Pos-20240607_MS_HEX-000817_HippC_PITC_Pos_004; RAW_FILE_NAME(Raw Source Name.LP)=20240521_MS_HEX-000817_Lipid_Pos_019.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20240524_MS_HEX-000817_Lipid_Neg_019.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20240523_MS_HEX-000817_Met_Pos_019.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20240524_MS_HEX-000817_Met_Neg_019.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20240522_MS_HEX-000817_HALO_Pos_019.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20240528_MS_HEX-000817_GM_Neg_019.mzML SUBJECT_SAMPLE_FACTORS Hipp_04 HSA-000038804 genotype:WT | Sample source:brain sex=Male; age=15; age_unit=month; region=Hippocampus; RAW_FILE_NAME(Raw Source Name.PITC)=20240607_MS_HEX-000817_PITC_Pos-20240607_MS_HEX-000817_HippC_PITC_Pos_005; RAW_FILE_NAME(Raw Source Name.LP)=20240521_MS_HEX-000817_Lipid_Pos_020.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20240524_MS_HEX-000817_Lipid_Neg_020.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20240523_MS_HEX-000817_Met_Pos_020.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20240524_MS_HEX-000817_Met_Neg_020.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20240522_MS_HEX-000817_HALO_Pos_020.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20240528_MS_HEX-000817_GM_Neg_020.mzML SUBJECT_SAMPLE_FACTORS Hipp_05 HSA-000038805 genotype:WT | Sample source:brain sex=Female; age=15; age_unit=month; region=Hippocampus; RAW_FILE_NAME(Raw Source Name.PITC)=20240607_MS_HEX-000817_PITC_Pos-20240607_MS_HEX-000817_HippC_PITC_Pos_006; RAW_FILE_NAME(Raw Source Name.LP)=20240521_MS_HEX-000817_Lipid_Pos_021.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20240524_MS_HEX-000817_Lipid_Neg_021.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20240523_MS_HEX-000817_Met_Pos_021.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20240524_MS_HEX-000817_Met_Neg_021.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20240522_MS_HEX-000817_HALO_Pos_021.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20240528_MS_HEX-000817_GM_Neg_021.mzML SUBJECT_SAMPLE_FACTORS Hipp_03 HSA-000038803 genotype:HOM KO ATP13A2 | Sample source:brain sex=Female; age=15; age_unit=month; region=Hippocampus; RAW_FILE_NAME(Raw Source Name.PITC)=20240607_MS_HEX-000817_PITC_Pos-20240607_MS_HEX-000817_HippC_PITC_Pos_007; RAW_FILE_NAME(Raw Source Name.LP)=20240521_MS_HEX-000817_Lipid_Pos_022.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20240524_MS_HEX-000817_Lipid_Neg_022.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20240523_MS_HEX-000817_Met_Pos_022.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20240524_MS_HEX-000817_Met_Neg_022.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20240522_MS_HEX-000817_HALO_Pos_022.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20240528_MS_HEX-000817_GM_Neg_022.mzML SUBJECT_SAMPLE_FACTORS Hipp_02 HSA-000038802 genotype:WT | Sample source:brain sex=Male; age=15; age_unit=month; region=Hippocampus; RAW_FILE_NAME(Raw Source Name.PITC)=20240607_MS_HEX-000817_PITC_Pos-20240607_MS_HEX-000817_HippC_PITC_Pos_008; RAW_FILE_NAME(Raw Source Name.LP)=20240521_MS_HEX-000817_Lipid_Pos_023.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20240524_MS_HEX-000817_Lipid_Neg_023.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20240523_MS_HEX-000817_Met_Pos_023.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20240524_MS_HEX-000817_Met_Neg_023.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20240522_MS_HEX-000817_HALO_Pos_023.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20240528_MS_HEX-000817_GM_Neg_023.mzML SUBJECT_SAMPLE_FACTORS Hipp_07 HSA-000038807 genotype:NA | Sample source:brain sex=Male; age=15; age_unit=month; region=Hippocampus; RAW_FILE_NAME(Raw Source Name.PITC)=20240607_MS_HEX-000817_PITC_Pos-20240607_MS_HEX-000817_HippC_PITC_Pos_009; RAW_FILE_NAME(Raw Source Name.LP)=20240521_MS_HEX-000817_Lipid_Pos_024.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20240524_MS_HEX-000817_Lipid_Neg_024.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20240523_MS_HEX-000817_Met_Pos_024.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20240524_MS_HEX-000817_Met_Neg_024.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20240522_MS_HEX-000817_HALO_Pos_024.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20240528_MS_HEX-000817_GM_Neg_024.mzML SUBJECT_SAMPLE_FACTORS Pool_Hippo_002 HSA-000039093 genotype:WT | Sample source:brain sex=NA; age=15; age_unit=month; region=Hippocampus; RAW_FILE_NAME(Raw Source Name.PITC)=20240607_MS_HEX-000817_PITC_Pos-20240607_MS_HEX-000817_HippC_PITC_Pos_010; RAW_FILE_NAME(Raw Source Name.LP)=20240521_MS_HEX-000817_Lipid_Pos_025.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20240524_MS_HEX-000817_Lipid_Neg_025.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20240523_MS_HEX-000817_Met_Pos_025.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20240524_MS_HEX-000817_Met_Neg_025.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20240522_MS_HEX-000817_HALO_Pos_025.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20240528_MS_HEX-000817_GM_Neg_025.mzML SUBJECT_SAMPLE_FACTORS Hipp_09 HSA-000038809 genotype:HOM KO ATP13A2 | Sample source:brain sex=Male; age=15; age_unit=month; region=Hippocampus; RAW_FILE_NAME(Raw Source Name.PITC)=20240607_MS_HEX-000817_PITC_Pos-20240607_MS_HEX-000817_HippC_PITC_Pos_011; RAW_FILE_NAME(Raw Source Name.LP)=20240521_MS_HEX-000817_Lipid_Pos_026.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20240524_MS_HEX-000817_Lipid_Neg_026.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20240523_MS_HEX-000817_Met_Pos_026.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20240524_MS_HEX-000817_Met_Neg_026.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20240522_MS_HEX-000817_HALO_Pos_026.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20240528_MS_HEX-000817_GM_Neg_026.mzML SUBJECT_SAMPLE_FACTORS Hipp_12 HSA-000038812 genotype:HOM KO ATP13A2 | Sample source:brain sex=Female; age=15; age_unit=month; region=Hippocampus; RAW_FILE_NAME(Raw Source Name.PITC)=20240607_MS_HEX-000817_PITC_Pos-20240607_MS_HEX-000817_HippC_PITC_Pos_012; RAW_FILE_NAME(Raw Source Name.LP)=20240521_MS_HEX-000817_Lipid_Pos_027.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20240524_MS_HEX-000817_Lipid_Neg_027.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20240523_MS_HEX-000817_Met_Pos_027.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20240524_MS_HEX-000817_Met_Neg_027.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20240522_MS_HEX-000817_HALO_Pos_027.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20240528_MS_HEX-000817_GM_Neg_027.mzML SUBJECT_SAMPLE_FACTORS Hipp_06 HSA-000038806 genotype:WT | Sample source:brain sex=Male; age=15; age_unit=month; region=Hippocampus; RAW_FILE_NAME(Raw Source Name.PITC)=20240607_MS_HEX-000817_PITC_Pos-20240607_MS_HEX-000817_HippC_PITC_Pos_013; RAW_FILE_NAME(Raw Source Name.LP)=20240521_MS_HEX-000817_Lipid_Pos_028.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20240524_MS_HEX-000817_Lipid_Neg_028.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20240523_MS_HEX-000817_Met_Pos_028.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20240524_MS_HEX-000817_Met_Neg_028.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20240522_MS_HEX-000817_HALO_Pos_028.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20240528_MS_HEX-000817_GM_Neg_028.mzML SUBJECT_SAMPLE_FACTORS Hipp_01 HSA-000038801 genotype:HOM KO ATP13A2 | Sample source:brain sex=Female; age=15; age_unit=month; region=Hippocampus; RAW_FILE_NAME(Raw Source Name.PITC)=20240607_MS_HEX-000817_PITC_Pos-20240607_MS_HEX-000817_HippC_PITC_Pos_014; RAW_FILE_NAME(Raw Source Name.LP)=20240521_MS_HEX-000817_Lipid_Pos_029.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20240524_MS_HEX-000817_Lipid_Neg_029.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20240523_MS_HEX-000817_Met_Pos_029.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20240524_MS_HEX-000817_Met_Neg_029.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20240522_MS_HEX-000817_HALO_Pos_029.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20240528_MS_HEX-000817_GM_Neg_029.mzML SUBJECT_SAMPLE_FACTORS Hipp_10 HSA-000038810 genotype:HOM KO ATP13A2 | Sample source:brain sex=Female; age=15; age_unit=month; region=Hippocampus; RAW_FILE_NAME(Raw Source Name.PITC)=20240607_MS_HEX-000817_PITC_Pos-20240607_MS_HEX-000817_HippC_PITC_Pos_015; RAW_FILE_NAME(Raw Source Name.LP)=20240521_MS_HEX-000817_Lipid_Pos_030.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20240524_MS_HEX-000817_Lipid_Neg_030.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20240523_MS_HEX-000817_Met_Pos_030.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20240524_MS_HEX-000817_Met_Neg_030.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20240522_MS_HEX-000817_HALO_Pos_030.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20240528_MS_HEX-000817_GM_Neg_030.mzML SUBJECT_SAMPLE_FACTORS Hipp_08 HSA-000038808 genotype:NA | Sample source:brain sex=Female; age=15; age_unit=month; region=Hippocampus; RAW_FILE_NAME(Raw Source Name.PITC)=20240607_MS_HEX-000817_PITC_Pos-20240607_MS_HEX-000817_HippC_PITC_Pos_016; RAW_FILE_NAME(Raw Source Name.LP)=20240521_MS_HEX-000817_Lipid_Pos_031.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20240524_MS_HEX-000817_Lipid_Neg_031.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20240523_MS_HEX-000817_Met_Pos_031.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20240524_MS_HEX-000817_Met_Neg_031.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20240522_MS_HEX-000817_HALO_Pos_031.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20240528_MS_HEX-000817_GM_Neg_031.mzML SUBJECT_SAMPLE_FACTORS Pool_Hippo_003 HSA-000039094 genotype:NA | Sample source:brain sex=NA; age=15; age_unit=month; region=Hippocampus; RAW_FILE_NAME(Raw Source Name.PITC)=20240607_MS_HEX-000817_PITC_Pos-20240607_MS_HEX-000817_HippC_PITC_Pos_017; RAW_FILE_NAME(Raw Source Name.LP)=20240521_MS_HEX-000817_Lipid_Pos_032.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20240524_MS_HEX-000817_Lipid_Neg_032.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20240523_MS_HEX-000817_Met_Pos_032.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20240524_MS_HEX-000817_Met_Neg_032.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20240522_MS_HEX-000817_HALO_Pos_032.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20240528_MS_HEX-000817_GM_Neg_032.mzML SUBJECT_SAMPLE_FACTORS Cortex_pool-1 HSA-000034484 genotype:NA | Sample source:brain sex=NA; age=4.5; age_unit=month; region=Cortex; RAW_FILE_NAME(Raw Source Name.PITC)=20231013_MS_HEX-000681_PITC_Pos-20231013_MS_HEX-000681_Cortex_PITC_Pos_001.mzML; RAW_FILE_NAME(Raw Source Name.LP)=20231006_MS_HEX-000681_Lipid_Pos-20231006_MS_HEX-000681_Cortex_Lipid_Pos_001.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20231008_MS_HEX-000681_Lipid_Neg-20231008_MS_HEX-000681_Cortex_Lipid_Neg_001.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20231007_MS_HEX-000681_Met_Pos-20231007_MS_HEX-000681_Cortex_Met_Pos_001.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20231008_MS_HEX-000681_Met_Neg-20231008_MS_HEX-000681_Cortex_Met_Neg_001.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20231007_MS_HEX-000681_HALO_Pos-20231007_MS_HEX-000681_Cortex_HALO_Pos_001.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20231010_MS_HEX-000681_GM_Neg-20231010_MS_HEX-000681_Cortex_GM_Neg_001.mzML SUBJECT_SAMPLE_FACTORS Cortex_09 HSA-000034472 genotype:HET KO ATP13A2 | Sample source:brain sex=Male; age=4.5; age_unit=month; region=Cortex; RAW_FILE_NAME(Raw Source Name.PITC)=20231013_MS_HEX-000681_PITC_Pos-20231013_MS_HEX-000681_Cortex_PITC_Pos_002.mzML; RAW_FILE_NAME(Raw Source Name.LP)=20231006_MS_HEX-000681_Lipid_Pos-20231006_MS_HEX-000681_Cortex_Lipid_Pos_002.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20231008_MS_HEX-000681_Lipid_Neg-20231008_MS_HEX-000681_Cortex_Lipid_Neg_002.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20231007_MS_HEX-000681_Met_Pos-20231007_MS_HEX-000681_Cortex_Met_Pos_002.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20231008_MS_HEX-000681_Met_Neg-20231008_MS_HEX-000681_Cortex_Met_Neg_002.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20231007_MS_HEX-000681_HALO_Pos-20231007_MS_HEX-000681_Cortex_HALO_Pos_002.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20231010_MS_HEX-000681_GM_Neg-20231010_MS_HEX-000681_Cortex_GM_Neg_002.mzML SUBJECT_SAMPLE_FACTORS Cortex_07 HSA-000034470 genotype:WT | Sample source:brain sex=Male; age=4.5; age_unit=month; region=Cortex; RAW_FILE_NAME(Raw Source Name.PITC)=20231013_MS_HEX-000681_PITC_Pos-20231013_MS_HEX-000681_Cortex_PITC_Pos_003.mzML; RAW_FILE_NAME(Raw Source Name.LP)=20231006_MS_HEX-000681_Lipid_Pos-20231006_MS_HEX-000681_Cortex_Lipid_Pos_003.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20231008_MS_HEX-000681_Lipid_Neg-20231008_MS_HEX-000681_Cortex_Lipid_Neg_003.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20231007_MS_HEX-000681_Met_Pos-20231007_MS_HEX-000681_Cortex_Met_Pos_003.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20231008_MS_HEX-000681_Met_Neg-20231008_MS_HEX-000681_Cortex_Met_Neg_003.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20231007_MS_HEX-000681_HALO_Pos-20231007_MS_HEX-000681_Cortex_HALO_Pos_003.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20231010_MS_HEX-000681_GM_Neg-20231010_MS_HEX-000681_Cortex_GM_Neg_003.mzML SUBJECT_SAMPLE_FACTORS Cortex_16 HSA-000034479 genotype:WT | Sample source:brain sex=Female; age=4.5; age_unit=month; region=Cortex; RAW_FILE_NAME(Raw Source Name.PITC)=20231013_MS_HEX-000681_PITC_Pos-20231013_MS_HEX-000681_Cortex_PITC_Pos_004.mzML; RAW_FILE_NAME(Raw Source Name.LP)=20231006_MS_HEX-000681_Lipid_Pos-20231006_MS_HEX-000681_Cortex_Lipid_Pos_004.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20231008_MS_HEX-000681_Lipid_Neg-20231008_MS_HEX-000681_Cortex_Lipid_Neg_004.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20231007_MS_HEX-000681_Met_Pos-20231007_MS_HEX-000681_Cortex_Met_Pos_004.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20231008_MS_HEX-000681_Met_Neg-20231008_MS_HEX-000681_Cortex_Met_Neg_004.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20231007_MS_HEX-000681_HALO_Pos-20231007_MS_HEX-000681_Cortex_HALO_Pos_004.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20231010_MS_HEX-000681_GM_Neg-20231010_MS_HEX-000681_Cortex_GM_Neg_004.mzML SUBJECT_SAMPLE_FACTORS Cortex_04 HSA-000034467 genotype:WT | Sample source:brain sex=Female; age=4.5; age_unit=month; region=Cortex; RAW_FILE_NAME(Raw Source Name.PITC)=20231013_MS_HEX-000681_PITC_Pos-20231013_MS_HEX-000681_Cortex_PITC_Pos_005.mzML; RAW_FILE_NAME(Raw Source Name.LP)=20231006_MS_HEX-000681_Lipid_Pos-20231006_MS_HEX-000681_Cortex_Lipid_Pos_005.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20231008_MS_HEX-000681_Lipid_Neg-20231008_MS_HEX-000681_Cortex_Lipid_Neg_005.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20231007_MS_HEX-000681_Met_Pos-20231007_MS_HEX-000681_Cortex_Met_Pos_005.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20231008_MS_HEX-000681_Met_Neg-20231008_MS_HEX-000681_Cortex_Met_Neg_005.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20231007_MS_HEX-000681_HALO_Pos-20231007_MS_HEX-000681_Cortex_HALO_Pos_005.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20231010_MS_HEX-000681_GM_Neg-20231010_MS_HEX-000681_Cortex_GM_Neg_005.mzML SUBJECT_SAMPLE_FACTORS Cortex_20 HSA-000034483 genotype:HOM KO ATP13A2 | Sample source:brain sex=Female; age=4.5; age_unit=month; region=Cortex; RAW_FILE_NAME(Raw Source Name.PITC)=20231013_MS_HEX-000681_PITC_Pos-20231013_MS_HEX-000681_Cortex_PITC_Pos_006.mzML; RAW_FILE_NAME(Raw Source Name.LP)=20231006_MS_HEX-000681_Lipid_Pos-20231006_MS_HEX-000681_Cortex_Lipid_Pos_006.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20231008_MS_HEX-000681_Lipid_Neg-20231008_MS_HEX-000681_Cortex_Lipid_Neg_006.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20231007_MS_HEX-000681_Met_Pos-20231007_MS_HEX-000681_Cortex_Met_Pos_006.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20231008_MS_HEX-000681_Met_Neg-20231008_MS_HEX-000681_Cortex_Met_Neg_006.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20231007_MS_HEX-000681_HALO_Pos-20231007_MS_HEX-000681_Cortex_HALO_Pos_006.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20231010_MS_HEX-000681_GM_Neg-20231010_MS_HEX-000681_Cortex_GM_Neg_006.mzML SUBJECT_SAMPLE_FACTORS Cortex_18 HSA-000034481 genotype:HET KO ATP13A2 | Sample source:brain sex=Female; age=4.5; age_unit=month; region=Cortex; RAW_FILE_NAME(Raw Source Name.PITC)=20231013_MS_HEX-000681_PITC_Pos-20231013_MS_HEX-000681_Cortex_PITC_Pos_007.mzML; RAW_FILE_NAME(Raw Source Name.LP)=20231006_MS_HEX-000681_Lipid_Pos-20231006_MS_HEX-000681_Cortex_Lipid_Pos_007.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20231008_MS_HEX-000681_Lipid_Neg-20231008_MS_HEX-000681_Cortex_Lipid_Neg_007.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20231007_MS_HEX-000681_Met_Pos-20231007_MS_HEX-000681_Cortex_Met_Pos_007.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20231008_MS_HEX-000681_Met_Neg-20231008_MS_HEX-000681_Cortex_Met_Neg_007.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20231007_MS_HEX-000681_HALO_Pos-20231007_MS_HEX-000681_Cortex_HALO_Pos_007.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20231010_MS_HEX-000681_GM_Neg-20231010_MS_HEX-000681_Cortex_GM_Neg_007.mzML SUBJECT_SAMPLE_FACTORS Cortex_15 HSA-000034478 genotype:HET KO ATP13A2 | Sample source:brain sex=Male; age=4.5; age_unit=month; region=Cortex; RAW_FILE_NAME(Raw Source Name.PITC)=20231013_MS_HEX-000681_PITC_Pos-20231013_MS_HEX-000681_Cortex_PITC_Pos_008.mzML; RAW_FILE_NAME(Raw Source Name.LP)=20231006_MS_HEX-000681_Lipid_Pos-20231006_MS_HEX-000681_Cortex_Lipid_Pos_008.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20231008_MS_HEX-000681_Lipid_Neg-20231008_MS_HEX-000681_Cortex_Lipid_Neg_008.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20231007_MS_HEX-000681_Met_Pos-20231007_MS_HEX-000681_Cortex_Met_Pos_008.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20231008_MS_HEX-000681_Met_Neg-20231008_MS_HEX-000681_Cortex_Met_Neg_008.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20231007_MS_HEX-000681_HALO_Pos-20231007_MS_HEX-000681_Cortex_HALO_Pos_008.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20231010_MS_HEX-000681_GM_Neg-20231010_MS_HEX-000681_Cortex_GM_Neg_008.mzML SUBJECT_SAMPLE_FACTORS Cortex_08 HSA-000034471 genotype:HOM KO ATP13A2 | Sample source:brain sex=Female; age=4.5; age_unit=month; region=Cortex; RAW_FILE_NAME(Raw Source Name.PITC)=20231013_MS_HEX-000681_PITC_Pos-20231013_MS_HEX-000681_Cortex_PITC_Pos_009.mzML; RAW_FILE_NAME(Raw Source Name.LP)=20231006_MS_HEX-000681_Lipid_Pos-20231006_MS_HEX-000681_Cortex_Lipid_Pos_009.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20231008_MS_HEX-000681_Lipid_Neg-20231008_MS_HEX-000681_Cortex_Lipid_Neg_009.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20231007_MS_HEX-000681_Met_Pos-20231007_MS_HEX-000681_Cortex_Met_Pos_009.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20231008_MS_HEX-000681_Met_Neg-20231008_MS_HEX-000681_Cortex_Met_Neg_009.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20231007_MS_HEX-000681_HALO_Pos-20231007_MS_HEX-000681_Cortex_HALO_Pos_009.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20231010_MS_HEX-000681_GM_Neg-20231010_MS_HEX-000681_Cortex_GM_Neg_009.mzML SUBJECT_SAMPLE_FACTORS Cortex_03 HSA-000034466 genotype:HET KO ATP13A2 | Sample source:brain sex=Male; age=4.5; age_unit=month; region=Cortex; RAW_FILE_NAME(Raw Source Name.PITC)=20231013_MS_HEX-000681_PITC_Pos-20231013_MS_HEX-000681_Cortex_PITC_Pos_010.mzML; RAW_FILE_NAME(Raw Source Name.LP)=20231006_MS_HEX-000681_Lipid_Pos-20231006_MS_HEX-000681_Cortex_Lipid_Pos_010.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20231008_MS_HEX-000681_Lipid_Neg-20231008_MS_HEX-000681_Cortex_Lipid_Neg_010.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20231007_MS_HEX-000681_Met_Pos-20231007_MS_HEX-000681_Cortex_Met_Pos_010.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20231008_MS_HEX-000681_Met_Neg-20231008_MS_HEX-000681_Cortex_Met_Neg_010.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20231007_MS_HEX-000681_HALO_Pos-20231007_MS_HEX-000681_Cortex_HALO_Pos_010.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20231010_MS_HEX-000681_GM_Neg-20231010_MS_HEX-000681_Cortex_GM_Neg_010.mzML SUBJECT_SAMPLE_FACTORS Cortex_14 HSA-000034477 genotype:HOM KO ATP13A2 | Sample source:brain sex=Female; age=4.5; age_unit=month; region=Cortex; RAW_FILE_NAME(Raw Source Name.PITC)=20231013_MS_HEX-000681_PITC_Pos-20231013_MS_HEX-000681_Cortex_PITC_Pos_011.mzML; RAW_FILE_NAME(Raw Source Name.LP)=20231006_MS_HEX-000681_Lipid_Pos-20231006_MS_HEX-000681_Cortex_Lipid_Pos_011.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20231008_MS_HEX-000681_Lipid_Neg-20231008_MS_HEX-000681_Cortex_Lipid_Neg_011.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20231007_MS_HEX-000681_Met_Pos-20231007_MS_HEX-000681_Cortex_Met_Pos_011.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20231008_MS_HEX-000681_Met_Neg-20231008_MS_HEX-000681_Cortex_Met_Neg_011.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20231007_MS_HEX-000681_HALO_Pos-20231007_MS_HEX-000681_Cortex_HALO_Pos_011.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20231010_MS_HEX-000681_GM_Neg-20231010_MS_HEX-000681_Cortex_GM_Neg_011.mzML SUBJECT_SAMPLE_FACTORS Cortex_pool-2 HSA-000035023 genotype:NA | Sample source:brain sex=NA; age=4.5; age_unit=month; region=Cortex; RAW_FILE_NAME(Raw Source Name.PITC)=20231013_MS_HEX-000681_PITC_Pos-20231013_MS_HEX-000681_Cortex_PITC_Pos_012.mzML; RAW_FILE_NAME(Raw Source Name.LP)=20231006_MS_HEX-000681_Lipid_Pos-20231006_MS_HEX-000681_Cortex_Lipid_Pos_012.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20231008_MS_HEX-000681_Lipid_Neg-20231008_MS_HEX-000681_Cortex_Lipid_Neg_012.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20231007_MS_HEX-000681_Met_Pos-20231007_MS_HEX-000681_Cortex_Met_Pos_012.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20231008_MS_HEX-000681_Met_Neg-20231008_MS_HEX-000681_Cortex_Met_Neg_012.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20231007_MS_HEX-000681_HALO_Pos-20231007_MS_HEX-000681_Cortex_HALO_Pos_012.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20231010_MS_HEX-000681_GM_Neg-20231010_MS_HEX-000681_Cortex_GM_Neg_012.mzML SUBJECT_SAMPLE_FACTORS Cortex_17 HSA-000034480 genotype:HOM KO ATP13A2 | Sample source:brain sex=Female; age=4.5; age_unit=month; region=Cortex; RAW_FILE_NAME(Raw Source Name.PITC)=20231013_MS_HEX-000681_PITC_Pos-20231013_MS_HEX-000681_Cortex_PITC_Pos_013.mzML; RAW_FILE_NAME(Raw Source Name.LP)=20231006_MS_HEX-000681_Lipid_Pos-20231006_MS_HEX-000681_Cortex_Lipid_Pos_013.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20231008_MS_HEX-000681_Lipid_Neg-20231008_MS_HEX-000681_Cortex_Lipid_Neg_013.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20231007_MS_HEX-000681_Met_Pos-20231007_MS_HEX-000681_Cortex_Met_Pos_013.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20231008_MS_HEX-000681_Met_Neg-20231008_MS_HEX-000681_Cortex_Met_Neg_013.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20231007_MS_HEX-000681_HALO_Pos-20231007_MS_HEX-000681_Cortex_HALO_Pos_013.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20231010_MS_HEX-000681_GM_Neg-20231010_MS_HEX-000681_Cortex_GM_Neg_013.mzML SUBJECT_SAMPLE_FACTORS Cortex_11 HSA-000034474 genotype:HOM KO ATP13A2 | Sample source:brain sex=Female; age=4.5; age_unit=month; region=Cortex; RAW_FILE_NAME(Raw Source Name.PITC)=20231013_MS_HEX-000681_PITC_Pos-20231013_MS_HEX-000681_Cortex_PITC_Pos_014.mzML; RAW_FILE_NAME(Raw Source Name.LP)=20231006_MS_HEX-000681_Lipid_Pos-20231006_MS_HEX-000681_Cortex_Lipid_Pos_014.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20231008_MS_HEX-000681_Lipid_Neg-20231008_MS_HEX-000681_Cortex_Lipid_Neg_014.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20231007_MS_HEX-000681_Met_Pos-20231007_MS_HEX-000681_Cortex_Met_Pos_014.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20231008_MS_HEX-000681_Met_Neg-20231008_MS_HEX-000681_Cortex_Met_Neg_014.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20231007_MS_HEX-000681_HALO_Pos-20231007_MS_HEX-000681_Cortex_HALO_Pos_014.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20231010_MS_HEX-000681_GM_Neg-20231010_MS_HEX-000681_Cortex_GM_Neg_014.mzML SUBJECT_SAMPLE_FACTORS Cortex_12 HSA-000034475 genotype:HET KO ATP13A2 | Sample source:brain sex=Male; age=4.5; age_unit=month; region=Cortex; RAW_FILE_NAME(Raw Source Name.PITC)=20231013_MS_HEX-000681_PITC_Pos-20231013_MS_HEX-000681_Cortex_PITC_Pos_015.mzML; RAW_FILE_NAME(Raw Source Name.LP)=20231006_MS_HEX-000681_Lipid_Pos-20231006_MS_HEX-000681_Cortex_Lipid_Pos_015.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20231008_MS_HEX-000681_Lipid_Neg-20231008_MS_HEX-000681_Cortex_Lipid_Neg_015.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20231007_MS_HEX-000681_Met_Pos-20231007_MS_HEX-000681_Cortex_Met_Pos_015.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20231008_MS_HEX-000681_Met_Neg-20231008_MS_HEX-000681_Cortex_Met_Neg_015.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20231007_MS_HEX-000681_HALO_Pos-20231007_MS_HEX-000681_Cortex_HALO_Pos_015.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20231010_MS_HEX-000681_GM_Neg-20231010_MS_HEX-000681_Cortex_GM_Neg_015.mzML SUBJECT_SAMPLE_FACTORS Cortex_01 HSA-000034464 genotype:WT | Sample source:brain sex=Female; age=4.5; age_unit=month; region=Cortex; RAW_FILE_NAME(Raw Source Name.PITC)=20231013_MS_HEX-000681_PITC_Pos-20231013_MS_HEX-000681_Cortex_PITC_Pos_016.mzML; RAW_FILE_NAME(Raw Source Name.LP)=20231006_MS_HEX-000681_Lipid_Pos-20231006_MS_HEX-000681_Cortex_Lipid_Pos_016.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20231008_MS_HEX-000681_Lipid_Neg-20231008_MS_HEX-000681_Cortex_Lipid_Neg_016.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20231007_MS_HEX-000681_Met_Pos-20231007_MS_HEX-000681_Cortex_Met_Pos_016.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20231008_MS_HEX-000681_Met_Neg-20231008_MS_HEX-000681_Cortex_Met_Neg_016.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20231007_MS_HEX-000681_HALO_Pos-20231007_MS_HEX-000681_Cortex_HALO_Pos_016.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20231010_MS_HEX-000681_GM_Neg-20231010_MS_HEX-000681_Cortex_GM_Neg_016.mzML SUBJECT_SAMPLE_FACTORS Cortex_13 HSA-000034476 genotype:WT | Sample source:brain sex=Male; age=4.5; age_unit=month; region=Cortex; RAW_FILE_NAME(Raw Source Name.PITC)=20231013_MS_HEX-000681_PITC_Pos-20231013_MS_HEX-000681_Cortex_PITC_Pos_017.mzML; RAW_FILE_NAME(Raw Source Name.LP)=20231006_MS_HEX-000681_Lipid_Pos-20231006_MS_HEX-000681_Cortex_Lipid_Pos_017.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20231008_MS_HEX-000681_Lipid_Neg-20231008_MS_HEX-000681_Cortex_Lipid_Neg_017.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20231007_MS_HEX-000681_Met_Pos-20231007_MS_HEX-000681_Cortex_Met_Pos_017.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20231008_MS_HEX-000681_Met_Neg-20231008_MS_HEX-000681_Cortex_Met_Neg_017.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20231007_MS_HEX-000681_HALO_Pos-20231007_MS_HEX-000681_Cortex_HALO_Pos_017.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20231010_MS_HEX-000681_GM_Neg-20231010_MS_HEX-000681_Cortex_GM_Neg_017.mzML SUBJECT_SAMPLE_FACTORS Cortex_19 HSA-000034482 genotype:WT | Sample source:brain sex=Female; age=4.5; age_unit=month; region=Cortex; RAW_FILE_NAME(Raw Source Name.PITC)=20231013_MS_HEX-000681_PITC_Pos-20231013_MS_HEX-000681_Cortex_PITC_Pos_018.mzML; RAW_FILE_NAME(Raw Source Name.LP)=20231006_MS_HEX-000681_Lipid_Pos-20231006_MS_HEX-000681_Cortex_Lipid_Pos_018.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20231008_MS_HEX-000681_Lipid_Neg-20231008_MS_HEX-000681_Cortex_Lipid_Neg_018.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20231007_MS_HEX-000681_Met_Pos-20231007_MS_HEX-000681_Cortex_Met_Pos_018.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20231008_MS_HEX-000681_Met_Neg-20231008_MS_HEX-000681_Cortex_Met_Neg_018.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20231007_MS_HEX-000681_HALO_Pos-20231007_MS_HEX-000681_Cortex_HALO_Pos_018.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20231010_MS_HEX-000681_GM_Neg-20231010_MS_HEX-000681_Cortex_GM_Neg_018.mzML SUBJECT_SAMPLE_FACTORS Cortex_02 HSA-000034465 genotype:HOM KO ATP13A2 | Sample source:brain sex=Male; age=4.5; age_unit=month; region=Cortex; RAW_FILE_NAME(Raw Source Name.PITC)=20231013_MS_HEX-000681_PITC_Pos-20231013_MS_HEX-000681_Cortex_PITC_Pos_019.mzML; RAW_FILE_NAME(Raw Source Name.LP)=20231006_MS_HEX-000681_Lipid_Pos-20231006_MS_HEX-000681_Cortex_Lipid_Pos_019.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20231008_MS_HEX-000681_Lipid_Neg-20231008_MS_HEX-000681_Cortex_Lipid_Neg_019.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20231007_MS_HEX-000681_Met_Pos-20231007_MS_HEX-000681_Cortex_Met_Pos_019.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20231008_MS_HEX-000681_Met_Neg-20231008_MS_HEX-000681_Cortex_Met_Neg_019.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20231007_MS_HEX-000681_HALO_Pos-20231007_MS_HEX-000681_Cortex_HALO_Pos_019.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20231010_MS_HEX-000681_GM_Neg-20231010_MS_HEX-000681_Cortex_GM_Neg_019.mzML SUBJECT_SAMPLE_FACTORS Cortex_05 HSA-000034468 genotype:HOM KO ATP13A2 | Sample source:brain sex=Male; age=4.5; age_unit=month; region=Cortex; RAW_FILE_NAME(Raw Source Name.PITC)=20231013_MS_HEX-000681_PITC_Pos-20231013_MS_HEX-000681_Cortex_PITC_Pos_020.mzML; RAW_FILE_NAME(Raw Source Name.LP)=20231006_MS_HEX-000681_Lipid_Pos-20231006_MS_HEX-000681_Cortex_Lipid_Pos_020.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20231008_MS_HEX-000681_Lipid_Neg-20231008_MS_HEX-000681_Cortex_Lipid_Neg_020.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20231007_MS_HEX-000681_Met_Pos-20231007_MS_HEX-000681_Cortex_Met_Pos_020.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20231008_MS_HEX-000681_Met_Neg-20231008_MS_HEX-000681_Cortex_Met_Neg_020.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20231007_MS_HEX-000681_HALO_Pos-20231007_MS_HEX-000681_Cortex_HALO_Pos_020.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20231010_MS_HEX-000681_GM_Neg-20231010_MS_HEX-000681_Cortex_GM_Neg_020.mzML SUBJECT_SAMPLE_FACTORS Cortex_10 HSA-000034473 genotype:WT | Sample source:brain sex=Male; age=4.5; age_unit=month; region=Cortex; RAW_FILE_NAME(Raw Source Name.PITC)=20231013_MS_HEX-000681_PITC_Pos-20231013_MS_HEX-000681_Cortex_PITC_Pos_021.mzML; RAW_FILE_NAME(Raw Source Name.LP)=20231006_MS_HEX-000681_Lipid_Pos-20231006_MS_HEX-000681_Cortex_Lipid_Pos_021.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20231008_MS_HEX-000681_Lipid_Neg-20231008_MS_HEX-000681_Cortex_Lipid_Neg_021.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20231007_MS_HEX-000681_Met_Pos-20231007_MS_HEX-000681_Cortex_Met_Pos_021.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20231008_MS_HEX-000681_Met_Neg-20231008_MS_HEX-000681_Cortex_Met_Neg_021.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20231007_MS_HEX-000681_HALO_Pos-20231007_MS_HEX-000681_Cortex_HALO_Pos_021.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20231010_MS_HEX-000681_GM_Neg-20231010_MS_HEX-000681_Cortex_GM_Neg_021.mzML SUBJECT_SAMPLE_FACTORS Cortex_06 HSA-000034469 genotype:HET KO ATP13A2 | Sample source:brain sex=Male; age=4.5; age_unit=month; region=Cortex; RAW_FILE_NAME(Raw Source Name.PITC)=20231013_MS_HEX-000681_PITC_Pos-20231013_MS_HEX-000681_Cortex_PITC_Pos_022.mzML; RAW_FILE_NAME(Raw Source Name.LP)=20231006_MS_HEX-000681_Lipid_Pos-20231006_MS_HEX-000681_Cortex_Lipid_Pos_022.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20231008_MS_HEX-000681_Lipid_Neg-20231008_MS_HEX-000681_Cortex_Lipid_Neg_022.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20231007_MS_HEX-000681_Met_Pos-20231007_MS_HEX-000681_Cortex_Met_Pos_022.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20231008_MS_HEX-000681_Met_Neg-20231008_MS_HEX-000681_Cortex_Met_Neg_022.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20231007_MS_HEX-000681_HALO_Pos-20231007_MS_HEX-000681_Cortex_HALO_Pos_022.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20231010_MS_HEX-000681_GM_Neg-20231010_MS_HEX-000681_Cortex_GM_Neg_022.mzML SUBJECT_SAMPLE_FACTORS Cortex_pool-3 HSA-000035024 genotype:NA | Sample source:brain sex=NA; age=4.5; age_unit=month; region=Cortex; RAW_FILE_NAME(Raw Source Name.PITC)=20231013_MS_HEX-000681_PITC_Pos-20231013_MS_HEX-000681_Cortex_PITC_Pos_023.mzML; RAW_FILE_NAME(Raw Source Name.LP)=20231006_MS_HEX-000681_Lipid_Pos-20231006_MS_HEX-000681_Cortex_Lipid_Pos_023.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20231008_MS_HEX-000681_Lipid_Neg-20231008_MS_HEX-000681_Cortex_Lipid_Neg_023.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20231007_MS_HEX-000681_Met_Pos-20231007_MS_HEX-000681_Cortex_Met_Pos_023.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20231008_MS_HEX-000681_Met_Neg-20231008_MS_HEX-000681_Cortex_Met_Neg_023.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20231007_MS_HEX-000681_HALO_Pos-20231007_MS_HEX-000681_Cortex_HALO_Pos_023.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20231010_MS_HEX-000681_GM_Neg-20231010_MS_HEX-000681_Cortex_GM_Neg_023.mzML SUBJECT_SAMPLE_FACTORS Hipp_pool-1 HSA-000034505 genotype:NA | Sample source:brain sex=NA; age=4.5; age_unit=month; region=Hippocampus; RAW_FILE_NAME(Raw Source Name.PITC)=20231013_MS_HEX-000681_PITC_Pos-20231013_MS_HEX-000681_HC_PITC_Pos_001.mzML; RAW_FILE_NAME(Raw Source Name.LP)=20231006_MS_HEX-000681_Lipid_Pos-20231006_MS_HEX-000681_HC_Lipid_Pos_001.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20231008_MS_HEX-000681_Lipid_Neg-20231008_MS_HEX-000681_HC_Lipid_Neg_001.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20231007_MS_HEX-000681_Met_Pos-20231007_MS_HEX-000681_HC_Met_Pos_001.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20231008_MS_HEX-000681_Met_Neg-20231008_MS_HEX-000681_HC_Met_Neg_001.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20231007_MS_HEX-000681_HALO_Pos-20231007_MS_HEX-000681_HC_HALO_Pos_001.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20231010_MS_HEX-000681_GM_Neg-20231010_MS_HEX-000681_HC_GM_Neg_001.mzML SUBJECT_SAMPLE_FACTORS Hipp_18 HSA-000034502 genotype:HET KO ATP13A2 | Sample source:brain sex=Female; age=4.5; age_unit=month; region=Hippocampus; RAW_FILE_NAME(Raw Source Name.PITC)=20231013_MS_HEX-000681_PITC_Pos-20231013_MS_HEX-000681_HC_PITC_Pos_002.mzML; RAW_FILE_NAME(Raw Source Name.LP)=20231006_MS_HEX-000681_Lipid_Pos-20231006_MS_HEX-000681_HC_Lipid_Pos_002.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20231008_MS_HEX-000681_Lipid_Neg-20231008_MS_HEX-000681_HC_Lipid_Neg_002.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20231007_MS_HEX-000681_Met_Pos-20231007_MS_HEX-000681_HC_Met_Pos_002.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20231008_MS_HEX-000681_Met_Neg-20231008_MS_HEX-000681_HC_Met_Neg_002.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20231007_MS_HEX-000681_HALO_Pos-20231007_MS_HEX-000681_HC_HALO_Pos_002.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20231010_MS_HEX-000681_GM_Neg-20231010_MS_HEX-000681_HC_GM_Neg_002.mzML SUBJECT_SAMPLE_FACTORS Hipp_06 HSA-000034490 genotype:HET KO ATP13A2 | Sample source:brain sex=Male; age=4.5; age_unit=month; region=Hippocampus; RAW_FILE_NAME(Raw Source Name.PITC)=20231013_MS_HEX-000681_PITC_Pos-20231013_MS_HEX-000681_HC_PITC_Pos_003.mzML; RAW_FILE_NAME(Raw Source Name.LP)=20231006_MS_HEX-000681_Lipid_Pos-20231006_MS_HEX-000681_HC_Lipid_Pos_003.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20231008_MS_HEX-000681_Lipid_Neg-20231008_MS_HEX-000681_HC_Lipid_Neg_003.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20231007_MS_HEX-000681_Met_Pos-20231007_MS_HEX-000681_HC_Met_Pos_003.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20231008_MS_HEX-000681_Met_Neg-20231008_MS_HEX-000681_HC_Met_Neg_003.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20231007_MS_HEX-000681_HALO_Pos-20231007_MS_HEX-000681_HC_HALO_Pos_003.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20231010_MS_HEX-000681_GM_Neg-20231010_MS_HEX-000681_HC_GM_Neg_003.mzML SUBJECT_SAMPLE_FACTORS Hipp_05 HSA-000034489 genotype:HOM KO ATP13A2 | Sample source:brain sex=Male; age=4.5; age_unit=month; region=Hippocampus; RAW_FILE_NAME(Raw Source Name.PITC)=20231013_MS_HEX-000681_PITC_Pos-20231013_MS_HEX-000681_HC_PITC_Pos_004.mzML; RAW_FILE_NAME(Raw Source Name.LP)=20231006_MS_HEX-000681_Lipid_Pos-20231006_MS_HEX-000681_HC_Lipid_Pos_004.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20231008_MS_HEX-000681_Lipid_Neg-20231008_MS_HEX-000681_HC_Lipid_Neg_004.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20231007_MS_HEX-000681_Met_Pos-20231007_MS_HEX-000681_HC_Met_Pos_004.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20231008_MS_HEX-000681_Met_Neg-20231008_MS_HEX-000681_HC_Met_Neg_004.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20231007_MS_HEX-000681_HALO_Pos-20231007_MS_HEX-000681_HC_HALO_Pos_004.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20231010_MS_HEX-000681_GM_Neg-20231010_MS_HEX-000681_HC_GM_Neg_004.mzML SUBJECT_SAMPLE_FACTORS Hipp_16 HSA-000034500 genotype:WT | Sample source:brain sex=Female; age=4.5; age_unit=month; region=Hippocampus; RAW_FILE_NAME(Raw Source Name.PITC)=20231013_MS_HEX-000681_PITC_Pos-20231013_MS_HEX-000681_HC_PITC_Pos_005.mzML; RAW_FILE_NAME(Raw Source Name.LP)=20231006_MS_HEX-000681_Lipid_Pos-20231006_MS_HEX-000681_HC_Lipid_Pos_005.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20231008_MS_HEX-000681_Lipid_Neg-20231008_MS_HEX-000681_HC_Lipid_Neg_005.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20231007_MS_HEX-000681_Met_Pos-20231007_MS_HEX-000681_HC_Met_Pos_005.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20231008_MS_HEX-000681_Met_Neg-20231008_MS_HEX-000681_HC_Met_Neg_005.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20231007_MS_HEX-000681_HALO_Pos-20231007_MS_HEX-000681_HC_HALO_Pos_005.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20231010_MS_HEX-000681_GM_Neg-20231010_MS_HEX-000681_HC_GM_Neg_005.mzML SUBJECT_SAMPLE_FACTORS Hipp_08 HSA-000034492 genotype:HOM KO ATP13A2 | Sample source:brain sex=Female; age=4.5; age_unit=month; region=Hippocampus; RAW_FILE_NAME(Raw Source Name.PITC)=20231013_MS_HEX-000681_PITC_Pos-20231013_MS_HEX-000681_HC_PITC_Pos_006.mzML; RAW_FILE_NAME(Raw Source Name.LP)=20231006_MS_HEX-000681_Lipid_Pos-20231006_MS_HEX-000681_HC_Lipid_Pos_006.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20231008_MS_HEX-000681_Lipid_Neg-20231008_MS_HEX-000681_HC_Lipid_Neg_006.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20231007_MS_HEX-000681_Met_Pos-20231007_MS_HEX-000681_HC_Met_Pos_006.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20231008_MS_HEX-000681_Met_Neg-20231008_MS_HEX-000681_HC_Met_Neg_006.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20231007_MS_HEX-000681_HALO_Pos-20231007_MS_HEX-000681_HC_HALO_Pos_006.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20231010_MS_HEX-000681_GM_Neg-20231010_MS_HEX-000681_HC_GM_Neg_006.mzML SUBJECT_SAMPLE_FACTORS Hipp_03 HSA-000034487 genotype:HET KO ATP13A2 | Sample source:brain sex=Male; age=4.5; age_unit=month; region=Hippocampus; RAW_FILE_NAME(Raw Source Name.PITC)=20231013_MS_HEX-000681_PITC_Pos-20231013_MS_HEX-000681_HC_PITC_Pos_007.mzML; RAW_FILE_NAME(Raw Source Name.LP)=20231006_MS_HEX-000681_Lipid_Pos-20231006_MS_HEX-000681_HC_Lipid_Pos_007.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20231008_MS_HEX-000681_Lipid_Neg-20231008_MS_HEX-000681_HC_Lipid_Neg_007.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20231007_MS_HEX-000681_Met_Pos-20231007_MS_HEX-000681_HC_Met_Pos_007.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20231008_MS_HEX-000681_Met_Neg-20231008_MS_HEX-000681_HC_Met_Neg_007.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20231007_MS_HEX-000681_HALO_Pos-20231007_MS_HEX-000681_HC_HALO_Pos_007.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20231010_MS_HEX-000681_GM_Neg-20231010_MS_HEX-000681_HC_GM_Neg_007.mzML SUBJECT_SAMPLE_FACTORS Hipp_01 HSA-000034485 genotype:WT | Sample source:brain sex=Female; age=4.5; age_unit=month; region=Hippocampus; RAW_FILE_NAME(Raw Source Name.PITC)=20231013_MS_HEX-000681_PITC_Pos-20231013_MS_HEX-000681_HC_PITC_Pos_008.mzML; RAW_FILE_NAME(Raw Source Name.LP)=20231006_MS_HEX-000681_Lipid_Pos-20231006_MS_HEX-000681_HC_Lipid_Pos_008.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20231008_MS_HEX-000681_Lipid_Neg-20231008_MS_HEX-000681_HC_Lipid_Neg_008.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20231007_MS_HEX-000681_Met_Pos-20231007_MS_HEX-000681_HC_Met_Pos_008.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20231008_MS_HEX-000681_Met_Neg-20231008_MS_HEX-000681_HC_Met_Neg_008.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20231007_MS_HEX-000681_HALO_Pos-20231007_MS_HEX-000681_HC_HALO_Pos_008.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20231010_MS_HEX-000681_GM_Neg-20231010_MS_HEX-000681_HC_GM_Neg_008.mzML SUBJECT_SAMPLE_FACTORS Hipp_20 HSA-000034504 genotype:HOM KO ATP13A2 | Sample source:brain sex=Female; age=4.5; age_unit=month; region=Hippocampus; RAW_FILE_NAME(Raw Source Name.PITC)=20231013_MS_HEX-000681_PITC_Pos-20231013_MS_HEX-000681_HC_PITC_Pos_009.mzML; RAW_FILE_NAME(Raw Source Name.LP)=20231006_MS_HEX-000681_Lipid_Pos-20231006_MS_HEX-000681_HC_Lipid_Pos_009.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20231008_MS_HEX-000681_Lipid_Neg-20231008_MS_HEX-000681_HC_Lipid_Neg_009.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20231007_MS_HEX-000681_Met_Pos-20231007_MS_HEX-000681_HC_Met_Pos_009.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20231008_MS_HEX-000681_Met_Neg-20231008_MS_HEX-000681_HC_Met_Neg_009.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20231007_MS_HEX-000681_HALO_Pos-20231007_MS_HEX-000681_HC_HALO_Pos_009.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20231010_MS_HEX-000681_GM_Neg-20231010_MS_HEX-000681_HC_GM_Neg_009.mzML SUBJECT_SAMPLE_FACTORS Hipp_13 HSA-000034497 genotype:WT | Sample source:brain sex=Male; age=4.5; age_unit=month; region=Hippocampus; RAW_FILE_NAME(Raw Source Name.PITC)=20231013_MS_HEX-000681_PITC_Pos-20231013_MS_HEX-000681_HC_PITC_Pos_010.mzML; RAW_FILE_NAME(Raw Source Name.LP)=20231006_MS_HEX-000681_Lipid_Pos-20231006_MS_HEX-000681_HC_Lipid_Pos_010.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20231008_MS_HEX-000681_Lipid_Neg-20231008_MS_HEX-000681_HC_Lipid_Neg_010.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20231007_MS_HEX-000681_Met_Pos-20231007_MS_HEX-000681_HC_Met_Pos_010.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20231008_MS_HEX-000681_Met_Neg-20231008_MS_HEX-000681_HC_Met_Neg_010.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20231007_MS_HEX-000681_HALO_Pos-20231007_MS_HEX-000681_HC_HALO_Pos_010.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20231010_MS_HEX-000681_GM_Neg-20231010_MS_HEX-000681_HC_GM_Neg_010.mzML SUBJECT_SAMPLE_FACTORS Hipp_pool-2 HSA-000035025 genotype:NA | Sample source:brain sex=NA; age=4.5; age_unit=month; region=Hippocampus; RAW_FILE_NAME(Raw Source Name.PITC)=20231013_MS_HEX-000681_PITC_Pos-20231013_MS_HEX-000681_HC_PITC_Pos_011.mzML; RAW_FILE_NAME(Raw Source Name.LP)=20231006_MS_HEX-000681_Lipid_Pos-20231006_MS_HEX-000681_HC_Lipid_Pos_011.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20231008_MS_HEX-000681_Lipid_Neg-20231008_MS_HEX-000681_HC_Lipid_Neg_011.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20231007_MS_HEX-000681_Met_Pos-20231007_MS_HEX-000681_HC_Met_Pos_011.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20231008_MS_HEX-000681_Met_Neg-20231008_MS_HEX-000681_HC_Met_Neg_011.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20231007_MS_HEX-000681_HALO_Pos-20231007_MS_HEX-000681_HC_HALO_Pos_011.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20231010_MS_HEX-000681_GM_Neg-20231010_MS_HEX-000681_HC_GM_Neg_011.mzML SUBJECT_SAMPLE_FACTORS Hipp_02 HSA-000034486 genotype:HOM KO ATP13A2 | Sample source:brain sex=Male; age=4.5; age_unit=month; region=Hippocampus; RAW_FILE_NAME(Raw Source Name.PITC)=20231013_MS_HEX-000681_PITC_Pos-20231013_MS_HEX-000681_HC_PITC_Pos_012.mzML; RAW_FILE_NAME(Raw Source Name.LP)=20231006_MS_HEX-000681_Lipid_Pos-20231006_MS_HEX-000681_HC_Lipid_Pos_012.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20231008_MS_HEX-000681_Lipid_Neg-20231008_MS_HEX-000681_HC_Lipid_Neg_012.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20231007_MS_HEX-000681_Met_Pos-20231007_MS_HEX-000681_HC_Met_Pos_012.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20231008_MS_HEX-000681_Met_Neg-20231008_MS_HEX-000681_HC_Met_Neg_012.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20231007_MS_HEX-000681_HALO_Pos-20231007_MS_HEX-000681_HC_HALO_Pos_012.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20231010_MS_HEX-000681_GM_Neg-20231010_MS_HEX-000681_HC_GM_Neg_012.mzML SUBJECT_SAMPLE_FACTORS Hipp_10 HSA-000034494 genotype:WT | Sample source:brain sex=Male; age=4.5; age_unit=month; region=Hippocampus; RAW_FILE_NAME(Raw Source Name.PITC)=20231013_MS_HEX-000681_PITC_Pos-20231013_MS_HEX-000681_HC_PITC_Pos_013.mzML; RAW_FILE_NAME(Raw Source Name.LP)=20231006_MS_HEX-000681_Lipid_Pos-20231006_MS_HEX-000681_HC_Lipid_Pos_013.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20231008_MS_HEX-000681_Lipid_Neg-20231008_MS_HEX-000681_HC_Lipid_Neg_013.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20231007_MS_HEX-000681_Met_Pos-20231007_MS_HEX-000681_HC_Met_Pos_013.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20231008_MS_HEX-000681_Met_Neg-20231008_MS_HEX-000681_HC_Met_Neg_013.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20231007_MS_HEX-000681_HALO_Pos-20231007_MS_HEX-000681_HC_HALO_Pos_013.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20231010_MS_HEX-000681_GM_Neg-20231010_MS_HEX-000681_HC_GM_Neg_013.mzML SUBJECT_SAMPLE_FACTORS Hipp_15 HSA-000034499 genotype:HET KO ATP13A2 | Sample source:brain sex=Male; age=4.5; age_unit=month; region=Hippocampus; RAW_FILE_NAME(Raw Source Name.PITC)=20231013_MS_HEX-000681_PITC_Pos-20231013_MS_HEX-000681_HC_PITC_Pos_014.mzML; RAW_FILE_NAME(Raw Source Name.LP)=20231006_MS_HEX-000681_Lipid_Pos-20231006_MS_HEX-000681_HC_Lipid_Pos_014.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20231008_MS_HEX-000681_Lipid_Neg-20231008_MS_HEX-000681_HC_Lipid_Neg_014.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20231007_MS_HEX-000681_Met_Pos-20231007_MS_HEX-000681_HC_Met_Pos_014.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20231008_MS_HEX-000681_Met_Neg-20231008_MS_HEX-000681_HC_Met_Neg_014.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20231007_MS_HEX-000681_HALO_Pos-20231007_MS_HEX-000681_HC_HALO_Pos_014.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20231010_MS_HEX-000681_GM_Neg-20231010_MS_HEX-000681_HC_GM_Neg_014.mzML SUBJECT_SAMPLE_FACTORS Hipp_14 HSA-000034498 genotype:HOM KO ATP13A2 | Sample source:brain sex=Female; age=4.5; age_unit=month; region=Hippocampus; RAW_FILE_NAME(Raw Source Name.PITC)=20231013_MS_HEX-000681_PITC_Pos-20231013_MS_HEX-000681_HC_PITC_Pos_015.mzML; RAW_FILE_NAME(Raw Source Name.LP)=20231006_MS_HEX-000681_Lipid_Pos-20231006_MS_HEX-000681_HC_Lipid_Pos_015.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20231008_MS_HEX-000681_Lipid_Neg-20231008_MS_HEX-000681_HC_Lipid_Neg_015.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20231007_MS_HEX-000681_Met_Pos-20231007_MS_HEX-000681_HC_Met_Pos_015.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20231008_MS_HEX-000681_Met_Neg-20231008_MS_HEX-000681_HC_Met_Neg_015.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20231007_MS_HEX-000681_HALO_Pos-20231007_MS_HEX-000681_HC_HALO_Pos_015.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20231010_MS_HEX-000681_GM_Neg-20231010_MS_HEX-000681_HC_GM_Neg_015.mzML SUBJECT_SAMPLE_FACTORS Hipp_11 HSA-000034495 genotype:HOM KO ATP13A2 | Sample source:brain sex=Female; age=4.5; age_unit=month; region=Hippocampus; RAW_FILE_NAME(Raw Source Name.PITC)=20231013_MS_HEX-000681_PITC_Pos-20231013_MS_HEX-000681_HC_PITC_Pos_016.mzML; RAW_FILE_NAME(Raw Source Name.LP)=20231006_MS_HEX-000681_Lipid_Pos-20231006_MS_HEX-000681_HC_Lipid_Pos_016.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20231008_MS_HEX-000681_Lipid_Neg-20231008_MS_HEX-000681_HC_Lipid_Neg_016.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20231007_MS_HEX-000681_Met_Pos-20231007_MS_HEX-000681_HC_Met_Pos_016.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20231008_MS_HEX-000681_Met_Neg-20231008_MS_HEX-000681_HC_Met_Neg_016.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20231007_MS_HEX-000681_HALO_Pos-20231007_MS_HEX-000681_HC_HALO_Pos_016.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20231010_MS_HEX-000681_GM_Neg-20231010_MS_HEX-000681_HC_GM_Neg_016.mzML SUBJECT_SAMPLE_FACTORS Hipp_19 HSA-000034503 genotype:WT | Sample source:brain sex=Female; age=4.5; age_unit=month; region=Hippocampus; RAW_FILE_NAME(Raw Source Name.PITC)=20231013_MS_HEX-000681_PITC_Pos-20231013_MS_HEX-000681_HC_PITC_Pos_017.mzML; RAW_FILE_NAME(Raw Source Name.LP)=20231006_MS_HEX-000681_Lipid_Pos-20231006_MS_HEX-000681_HC_Lipid_Pos_017.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20231008_MS_HEX-000681_Lipid_Neg-20231008_MS_HEX-000681_HC_Lipid_Neg_017.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20231007_MS_HEX-000681_Met_Pos-20231007_MS_HEX-000681_HC_Met_Pos_017.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20231008_MS_HEX-000681_Met_Neg-20231008_MS_HEX-000681_HC_Met_Neg_017.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20231007_MS_HEX-000681_HALO_Pos-20231007_MS_HEX-000681_HC_HALO_Pos_017.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20231010_MS_HEX-000681_GM_Neg-20231010_MS_HEX-000681_HC_GM_Neg_017.mzML SUBJECT_SAMPLE_FACTORS Hipp_09 HSA-000034493 genotype:HET KO ATP13A2 | Sample source:brain sex=Male; age=4.5; age_unit=month; region=Hippocampus; RAW_FILE_NAME(Raw Source Name.PITC)=20231013_MS_HEX-000681_PITC_Pos-20231013_MS_HEX-000681_HC_PITC_Pos_018.mzML; RAW_FILE_NAME(Raw Source Name.LP)=20231006_MS_HEX-000681_Lipid_Pos-20231006_MS_HEX-000681_HC_Lipid_Pos_018.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20231008_MS_HEX-000681_Lipid_Neg-20231008_MS_HEX-000681_HC_Lipid_Neg_018.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20231007_MS_HEX-000681_Met_Pos-20231007_MS_HEX-000681_HC_Met_Pos_018.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20231008_MS_HEX-000681_Met_Neg-20231008_MS_HEX-000681_HC_Met_Neg_018.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20231007_MS_HEX-000681_HALO_Pos-20231007_MS_HEX-000681_HC_HALO_Pos_018.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20231010_MS_HEX-000681_GM_Neg-20231010_MS_HEX-000681_HC_GM_Neg_018.mzML SUBJECT_SAMPLE_FACTORS Hipp_04 HSA-000034488 genotype:WT | Sample source:brain sex=Female; age=4.5; age_unit=month; region=Hippocampus; RAW_FILE_NAME(Raw Source Name.PITC)=20231013_MS_HEX-000681_PITC_Pos-20231013_MS_HEX-000681_HC_PITC_Pos_019.mzML; RAW_FILE_NAME(Raw Source Name.LP)=20231006_MS_HEX-000681_Lipid_Pos-20231006_MS_HEX-000681_HC_Lipid_Pos_019.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20231008_MS_HEX-000681_Lipid_Neg-20231008_MS_HEX-000681_HC_Lipid_Neg_019.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20231007_MS_HEX-000681_Met_Pos-20231007_MS_HEX-000681_HC_Met_Pos_019.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20231008_MS_HEX-000681_Met_Neg-20231008_MS_HEX-000681_HC_Met_Neg_019.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20231007_MS_HEX-000681_HALO_Pos-20231007_MS_HEX-000681_HC_HALO_Pos_019.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20231010_MS_HEX-000681_GM_Neg-20231010_MS_HEX-000681_HC_GM_Neg_019.mzML SUBJECT_SAMPLE_FACTORS Hipp_17 HSA-000034501 genotype:HOM KO ATP13A2 | Sample source:brain sex=Female; age=4.5; age_unit=month; region=Hippocampus; RAW_FILE_NAME(Raw Source Name.PITC)=20231013_MS_HEX-000681_PITC_Pos-20231013_MS_HEX-000681_HC_PITC_Pos_020.mzML; RAW_FILE_NAME(Raw Source Name.LP)=20231006_MS_HEX-000681_Lipid_Pos-20231006_MS_HEX-000681_HC_Lipid_Pos_020.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20231008_MS_HEX-000681_Lipid_Neg-20231008_MS_HEX-000681_HC_Lipid_Neg_020.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20231007_MS_HEX-000681_Met_Pos-20231007_MS_HEX-000681_HC_Met_Pos_020.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20231008_MS_HEX-000681_Met_Neg-20231008_MS_HEX-000681_HC_Met_Neg_020.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20231007_MS_HEX-000681_HALO_Pos-20231007_MS_HEX-000681_HC_HALO_Pos_020.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20231010_MS_HEX-000681_GM_Neg-20231010_MS_HEX-000681_HC_GM_Neg_020.mzML SUBJECT_SAMPLE_FACTORS Hipp_12 HSA-000034496 genotype:HET KO ATP13A2 | Sample source:brain sex=Male; age=4.5; age_unit=month; region=Hippocampus; RAW_FILE_NAME(Raw Source Name.PITC)=20231013_MS_HEX-000681_PITC_Pos-20231013_MS_HEX-000681_HC_PITC_Pos_021.mzML; RAW_FILE_NAME(Raw Source Name.LP)=20231006_MS_HEX-000681_Lipid_Pos-20231006_MS_HEX-000681_HC_Lipid_Pos_021.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20231008_MS_HEX-000681_Lipid_Neg-20231008_MS_HEX-000681_HC_Lipid_Neg_021.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20231007_MS_HEX-000681_Met_Pos-20231007_MS_HEX-000681_HC_Met_Pos_021.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20231008_MS_HEX-000681_Met_Neg-20231008_MS_HEX-000681_HC_Met_Neg_021.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20231007_MS_HEX-000681_HALO_Pos-20231007_MS_HEX-000681_HC_HALO_Pos_021.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20231010_MS_HEX-000681_GM_Neg-20231010_MS_HEX-000681_HC_GM_Neg_021.mzML SUBJECT_SAMPLE_FACTORS Hipp_07 HSA-000034491 genotype:WT | Sample source:brain sex=Male; age=4.5; age_unit=month; region=Hippocampus; RAW_FILE_NAME(Raw Source Name.PITC)=20231013_MS_HEX-000681_PITC_Pos-20231013_MS_HEX-000681_HC_PITC_Pos_022.mzML; RAW_FILE_NAME(Raw Source Name.LP)=20231006_MS_HEX-000681_Lipid_Pos-20231006_MS_HEX-000681_HC_Lipid_Pos_022.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20231008_MS_HEX-000681_Lipid_Neg-20231008_MS_HEX-000681_HC_Lipid_Neg_022.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20231007_MS_HEX-000681_Met_Pos-20231007_MS_HEX-000681_HC_Met_Pos_022.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20231008_MS_HEX-000681_Met_Neg-20231008_MS_HEX-000681_HC_Met_Neg_022.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20231007_MS_HEX-000681_HALO_Pos-20231007_MS_HEX-000681_HC_HALO_Pos_022.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20231010_MS_HEX-000681_GM_Neg-20231010_MS_HEX-000681_HC_GM_Neg_022.mzML SUBJECT_SAMPLE_FACTORS Hipp_pool-3 HSA-000035026 genotype:NA | Sample source:brain sex=NA; age=4.5; age_unit=month; region=Hippocampus; RAW_FILE_NAME(Raw Source Name.PITC)=20231013_MS_HEX-000681_PITC_Pos-20231013_MS_HEX-000681_HC_PITC_Pos_023.mzML; RAW_FILE_NAME(Raw Source Name.LP)=20231006_MS_HEX-000681_Lipid_Pos-20231006_MS_HEX-000681_HC_Lipid_Pos_023.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20231008_MS_HEX-000681_Lipid_Neg-20231008_MS_HEX-000681_HC_Lipid_Neg_023.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20231007_MS_HEX-000681_Met_Pos-20231007_MS_HEX-000681_HC_Met_Pos_023.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20231008_MS_HEX-000681_Met_Neg-20231008_MS_HEX-000681_HC_Met_Neg_023.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20231007_MS_HEX-000681_HALO_Pos-20231007_MS_HEX-000681_HC_HALO_Pos_023.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20231010_MS_HEX-000681_GM_Neg-20231010_MS_HEX-000681_HC_GM_Neg_023.mzML #COLLECTION CO:COLLECTION_SUMMARY Heterozygous Atp13a2<tm1Pjsch> animals of genotype CO:COLLECTION_SUMMARY B6N.129S6(Cg)-Atp13a2tm1Pjsch/J were obtained from The Jackson Laboratory (JAX CO:COLLECTION_SUMMARY strain 021914)17 and were crossed to generate homozygous Atp13a2 KO (Atp13a2 CO:COLLECTION_SUMMARY –/–) animals. For both the 5-month and 15-month-old cohort, female and male CO:COLLECTION_SUMMARY mice were used in comparable percentages (see table below). In case of the CO:COLLECTION_SUMMARY 15-month-old Atp13a2 KO cohort, one of the animals died prior to study CO:COLLECTION_SUMMARY conclusion and was excluded. Animals were maintained and all procedures CO:COLLECTION_SUMMARY performed in adherence to ethical regulations and protocols approved by the CO:COLLECTION_SUMMARY Denali Therapeutics Inc. Institutional Animal Care and Use Committee (IACUC). CO:COLLECTION_SUMMARY Mice were housed under a 12-h light/12-h dark cycle and had access to water and CO:COLLECTION_SUMMARY standard rodent diet ad libitum. Running wheels were provided for enrichment to CO:COLLECTION_SUMMARY the cohort that was aged to 15 months.Animals were deeply anesthetized via CO:COLLECTION_SUMMARY intraperitoneal injection of 2.5% Avertin and transcardially perfused with CO:COLLECTION_SUMMARY ice-cold PBS using a peristaltic pump (Gilson Inc. Minipuls Evolution). The CO:COLLECTION_SUMMARY brain was then removed and one hemisphere sub-dissected into the anterior cortex CO:COLLECTION_SUMMARY and hippocampus, while the other was retained without sub-dissection. Tissue CO:COLLECTION_SUMMARY samples were individually weighed, flash frozen on dry ice and stored at -80°C CO:COLLECTION_SUMMARY for subsequent analysis. CO:SAMPLE_TYPE Brain CO:STORAGE_CONDITIONS -80℃ CO:COLLECTION_VIALS Lobind 1.5 mL Eppendorf tubes CO:STORAGE_VIALS Lobind 1.5 mL Eppendorf tubes #TREATMENT TR:TREATMENT_SUMMARY No treatment #SAMPLEPREP SP:SAMPLEPREP_SUMMARY For tissue samples, 20 (± 3) mg of anterior cortex or 15 (± 2) mg of SP:SAMPLEPREP_SUMMARY hippocampus from the left hemisphere of each individual animal was dissected, SP:SAMPLEPREP_SUMMARY weighed and flash frozen during tissue collection. Lipids and metabolites were SP:SAMPLEPREP_SUMMARY extracted from the frozen samples using 400 mL of HPLC-grade methanol (Fisher SP:SAMPLEPREP_SUMMARY Chemical; # A452-4) containing stable-isotope internal standards and homogenized SP:SAMPLEPREP_SUMMARY with a 3 mm tungsten carbide bead for 45 s at 25 Hz on TissueLyzer II (QIAGEN, SP:SAMPLEPREP_SUMMARY #85300). The methanol fraction was isolated via centrifugation (20 min at 4°C, SP:SAMPLEPREP_SUMMARY 14,000 x g, transferred to a 96-well sample collection plate (Waters; SP:SAMPLEPREP_SUMMARY #186005837) and incubated for 1 h, at -20°C for protein precipitation, SP:SAMPLEPREP_SUMMARY followed by an additional 20 min centrifugation (4,000 x g at 4°C). The SP:SAMPLEPREP_SUMMARY supernatant was transferred to glass vial plates (Analytical systems, #27350) SP:SAMPLEPREP_SUMMARY for LCMS analysis. SP:PROCESSING_STORAGE_CONDITIONS On ice SP:EXTRACT_STORAGE -20℃ #CHROMATOGRAPHY CH:CHROMATOGRAPHY_TYPE Ion exchange CH:INSTRUMENT_NAME Agilent 1290 Infinity II CH:COLUMN_NAME Imtakt Intrada Organic Acid (150 × 2 mm, 3 um) CH:SOLVENT_A 10% acetonitrile/90% water; 0.1% formic acid CH:SOLVENT_B 10% acetonitrile/90% water; 100mM ammonium formate CH:FLOW_GRADIENT 0.0-1.0 min at 0% B; 1.0-7.0 min to 100% B; 7.1 at 0% B; and 7.1-10 min at 0% B. CH:FLOW_RATE 0.20 mL/min CH:COLUMN_TEMPERATURE 55 #ANALYSIS AN:ANALYSIS_TYPE MS #MS MS:INSTRUMENT_NAME ABI Sciex 6500+ QTrap MS:INSTRUMENT_TYPE Triple quadrupole MS:MS_TYPE ESI MS:ION_MODE NEGATIVE MS:MS_COMMENTS curtain gas at 30 psi; collision gas was set at medium; ion spray voltage at MS:MS_COMMENTS 4,500 V; temperature at 600°C; ion source Gas 1 at 50 psi; ion source Gas 2 at MS:MS_COMMENTS 60 psi #MS_METABOLITE_DATA MS_METABOLITE_DATA:UNITS normalized peak area MS_METABOLITE_DATA_START Samples HSA-000038800 HSA-000038799 HSA-000038794 HSA-000038788 HSA-000038797 HSA-000038790 HSA-000038798 HSA-000038795 HSA-000039091 HSA-000038796 HSA-000038791 HSA-000038787 HSA-000038792 HSA-000038793 HSA-000038789 HSA-000039092 HSA-000038814 HSA-000038813 HSA-000038811 HSA-000038804 HSA-000038805 HSA-000038803 HSA-000038802 HSA-000038807 HSA-000039093 HSA-000038809 HSA-000038812 HSA-000038806 HSA-000038801 HSA-000038810 HSA-000038808 HSA-000039094 HSA-000034484 HSA-000034472 HSA-000034470 HSA-000034479 HSA-000034467 HSA-000034483 HSA-000034481 HSA-000034478 HSA-000034471 HSA-000034466 HSA-000034477 HSA-000035023 HSA-000034480 HSA-000034474 HSA-000034475 HSA-000034464 HSA-000034476 HSA-000034482 HSA-000034465 HSA-000034468 HSA-000034473 HSA-000034469 HSA-000035024 HSA-000034505 HSA-000034502 HSA-000034490 HSA-000034489 HSA-000034500 HSA-000034492 HSA-000034487 HSA-000034485 HSA-000034504 HSA-000034497 HSA-000035025 HSA-000034486 HSA-000034494 HSA-000034499 HSA-000034498 HSA-000034495 HSA-000034503 HSA-000034493 HSA-000034488 HSA-000034501 HSA-000034496 HSA-000034491 HSA-000035026 Factors genotype:WT | Sample source:brain genotype:HOM KO ATP13A2 | Sample source:brain genotype:HOM KO ATP13A2 | Sample source:brain genotype:WT | Sample source:brain genotype:HOM KO ATP13A2 | Sample source:brain genotype:HOM KO ATP13A2 | Sample source:brain genotype:WT | Sample source:brain genotype:NA | Sample source:brain genotype:HOM KO ATP13A2 | Sample source:brain genotype:WT | Sample source:brain genotype:WT | Sample source:brain genotype:HOM KO ATP13A2 | Sample source:brain genotype:WT | Sample source:brain genotype:WT | Sample source:brain genotype:NA | Sample source:brain genotype:NA | Sample source:brain genotype:WT | Sample source:brain genotype:WT | Sample source:brain genotype:HOM KO ATP13A2 | Sample source:brain genotype:WT | Sample source:brain genotype:WT | Sample source:brain genotype:HOM KO ATP13A2 | Sample source:brain genotype:WT | Sample source:brain genotype:NA | Sample source:brain genotype:WT | Sample source:brain genotype:HOM KO ATP13A2 | Sample source:brain genotype:HOM KO ATP13A2 | Sample source:brain genotype:WT | Sample source:brain genotype:HOM KO ATP13A2 | Sample source:brain genotype:HOM KO ATP13A2 | Sample source:brain genotype:NA | Sample source:brain genotype:NA | Sample source:brain genotype:NA | Sample source:brain genotype:HET KO ATP13A2 | Sample source:brain genotype:WT | Sample source:brain genotype:WT | Sample source:brain genotype:WT | Sample source:brain genotype:HOM KO ATP13A2 | Sample source:brain genotype:HET KO ATP13A2 | Sample source:brain genotype:HET KO ATP13A2 | Sample source:brain genotype:HOM KO ATP13A2 | Sample source:brain genotype:HET KO ATP13A2 | Sample source:brain genotype:HOM KO ATP13A2 | Sample source:brain genotype:NA | Sample source:brain genotype:HOM KO ATP13A2 | Sample source:brain genotype:HOM KO ATP13A2 | Sample source:brain genotype:HET KO ATP13A2 | Sample source:brain genotype:WT | Sample source:brain genotype:WT | Sample source:brain genotype:WT | Sample source:brain genotype:HOM KO ATP13A2 | Sample source:brain genotype:HOM KO ATP13A2 | Sample source:brain genotype:WT | Sample source:brain genotype:HET KO ATP13A2 | Sample source:brain genotype:NA | Sample source:brain genotype:NA | Sample source:brain genotype:HET KO ATP13A2 | Sample source:brain genotype:HET KO ATP13A2 | Sample source:brain genotype:HOM KO ATP13A2 | Sample source:brain genotype:WT | Sample source:brain genotype:HOM KO ATP13A2 | Sample source:brain genotype:HET KO ATP13A2 | Sample source:brain genotype:WT | Sample source:brain genotype:HOM KO ATP13A2 | Sample source:brain genotype:WT | Sample source:brain genotype:NA | Sample source:brain genotype:HOM KO ATP13A2 | Sample source:brain genotype:WT | Sample source:brain genotype:HET KO ATP13A2 | Sample source:brain genotype:HOM KO ATP13A2 | Sample source:brain genotype:HOM KO ATP13A2 | Sample source:brain genotype:WT | Sample source:brain genotype:HET KO ATP13A2 | Sample source:brain genotype:WT | Sample source:brain genotype:HOM KO ATP13A2 | Sample source:brain genotype:HET KO ATP13A2 | Sample source:brain genotype:WT | Sample source:brain genotype:NA | Sample source:brain 13C3-Citric acid N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. 13C4-Fumaric acid N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. 13C4-Malic acid N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. 13C4-Succinic acid N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. 13C5-Itaconic acid N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. 13C5-Oxoglutaric acid N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. 15N5-ADP N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. 2-Hydroxyglutarate N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. 2-Phosphoglyceric acid N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. 3-Hydroxybutyric acid N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. 3-Phosphoglyceric acid N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. 6-Phosphogluconic acid N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. ADP 3.015 3.852 4.019 4.043 2.866 4.195 4.417 4.448 3.394 4.413 4.738 3.307 4.977 3.987 4.353 4.068 3.155 2.883 4.982 3.978 3.988 3.378 2.505 4.614 3.16 4.695 4.824 4.486 2.826 3.778 4.15 2.939 4.121 3.121 2.657 2.93 4.879 4.65 4.457 5.125 3.025 3.464 3.892 3.832 4.781 3.411 3.899 4.228 3.372 4.71 2.782 4.23 3.792 2.554 3.825 3.148 2.52 1.888 1.386 1.533 2.703 2.614 2.239 2.097 2.122 2.706 2.242 1.821 1.91 2.055 1.956 2.604 2.293 2.556 2.682 2.204 1.952 3.033 Acetoacetic acid N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. Adenosine monophosphate 11.874 11.694 11.253 10.812 12.094 12.703 12.65 13.939 12.041 15.48 12.75 11.536 12.824 12.203 9.667 12.23 8.396 9.922 12.728 13.468 11.575 8.542 5.139 14.007 7.723 13.062 14.003 14.61 6.269 11.683 12.951 8.034 11.405 9.208 8.289 10.687 15.817 10.733 10.442 10.444 10.942 11.099 14.554 13.264 17.101 13.768 10.503 16.126 13.669 15.763 8.506 13.346 13.967 9.928 14.266 9.92 7.635 8.945 7.049 9.257 11.926 10.33 9.967 8.342 9.654 11.137 9.235 7.563 7.07 10.501 11.261 9.302 8.909 11.321 10.116 10.537 10.117 11.034 Adenosine triphosphate N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. Adenosine triphosphate-d4 N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. Alanine N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. Alanine-d4 N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. Arginine N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. Arginine-d4C13 N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. Asparagine N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. Aspartic acid N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. 309.446 183.195 158.951 239.17 340.052 246.385 252.422 283.511 302.949 280.718 292.653 347.497 386.575 390.017 260.579 333.549 373.189 464.373 234.112 338.106 291.441 218.177 426.53 213.144 176.663 196.494 124.521 164.345 230.176 165.736 158.929 213.131 193.393 156.752 148.134 131.968 177.65 247.648 167.319 178.359 148.058 304.749 170.299 216.744 181.643 164.241 Aspartic acid-d3 N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. Dihydroxyacetone phosphate 2.531 1.681 1.536 1.028 2.158 1.174 6.939 1.55 2.903 2.444 1.299 2.566 1.273 1.97 1.28 2.454 3.93 4.632 8.528 6.018 14.1 3.206 1.44 4.584 3.885 5.588 2.85 6.024 1.555 10.048 10.585 3.744 10.753 2.898 2.632 4.392 7.587 17.258 13.996 5.183 4.664 5.007 4.028 10.377 12.428 5.857 5.875 6.548 12.123 13.077 3.162 9.484 7.024 2.397 10.537 12.31 19.115 6.953 5.538 6.978 10.035 8.6 8.612 25.047 5.582 11.442 5.565 5.555 5.887 24.808 7.643 9.174 6.054 15.355 12.069 8.572 4.978 9.716 Erythose 4-phosphate 0.939 0.697 0.709 0.265 0.627 0.438 2.046 0.438 0.844 0.949 0.462 0.586 0.414 0.613 0.363 0.946 0.772 1.137 2.178 2.238 2.572 1.174 0.184 1.943 0.815 1.923 0.92 1.858 0.37 2.463 2.252 0.808 3.393 1.742 1.323 1.575 3.28 3.791 2.809 2.555 2.389 2.363 2.23 3.236 4.603 2.96 2.831 3.329 3.727 3.905 2.19 3.488 3.158 1.592 3.286 2.196 2.972 1.734 1.086 1.632 2.246 2.046 1.938 3.244 1.584 2.108 1.457 1.534 1.378 3.208 1.678 1.977 1.647 2.585 2.233 1.732 1.623 1.973 Fructose 1,6-bisphosphate 0.605 0.572 0.482 0.379 0.41 0.378 1.479 0.59 0.544 0.486 0.489 0.396 0.787 0.42 0.375 0.57 0.881 0.654 1.229 1.506 3.774 0.792 0.496 0.811 0.871 1.008 0.424 0.967 0.352 1.43 1.813 0.841 1.188 0.455 0.38 0.428 0.847 2.036 1.395 0.725 0.647 0.84 0.648 1.572 1.241 0.914 0.84 1.086 0.869 1.462 0.58 1.296 0.972 0.661 1.604 8.223 7.918 1.596 3.486 1.447 2.03 2.524 2.314 5.595 1.23 8.346 2.208 0.863 2.889 2.684 1.586 4.096 1.267 1.705 3.559 1.801 1.095 8.225 Fructose 1-phosphate N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. Fructose 6-phosphate N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. 5.969 3.635 3.112 3.858 6.107 6.769 6.02 6.314 5.195 6.501 5.42 6.756 7.946 5.821 6.991 6.594 8.729 7.743 6.636 8.107 9.168 6.312 9.086 9.776 7.997 7.536 5.588 6.238 7.882 8.948 7.246 10.489 8.565 10.876 8.582 8.246 7.661 8.743 8.085 8.017 9.262 8.842 8.145 9.828 8.23 11.505 Fumaric acid N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. Glucose 1-phosphate 0.232 0.254 0.235 0.222 0.277 0.248 0.34 0.217 0.251 0.255 0.268 0.313 0.257 0.263 0.262 0.26 0.239 0.23 0.346 0.45 0.725 0.196 0.136 0.275 0.266 0.349 0.345 0.304 0.171 0.368 0.71 0.214 N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. Glucose 6-phosphate 11.757 12.585 11.298 13.035 13.715 12.92 20.865 13.89 12.196 13.864 11.837 13.872 12.809 13.238 11.53 13.528 15.91 15.695 24.915 27.006 54.631 12.482 10.185 16.242 16.317 18.446 16.842 20.348 12.915 22.882 50.666 16.045 18.175 10.135 8.67 13.858 14.334 20.451 21.774 15.57 13.205 15.46 13.594 18.527 16.208 16.652 14.328 16.406 18.534 18.712 14.51 19.586 15.676 13.262 21.76 31.493 48.749 17.671 18.812 17.919 21.292 21.109 23.513 56.302 18.01 31.773 18.099 17.334 19.235 42.165 18.969 26.371 19.235 29.55 25.502 19.881 17.416 33.934 Glutamic acid N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. Glutamic acid-d3 N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. Glutamine N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. Glyceraldehyde 3-phosphate 3.705 2.499 2.139 1.502 2.912 1.539 10.41 2.18 3.719 3.394 1.715 3.641 1.948 2.594 1.643 3.497 5.282 6.49 12.117 9.176 18.883 4.731 2.109 6.367 5.558 7.813 3.974 8.504 2.145 13.156 15.796 5.266 8.708 2.172 1.932 3.576 5.775 13.2 10.587 3.963 3.552 3.468 3.012 7.789 9.36 4.809 4.299 4.779 9.3 9.992 2.339 7.062 5.253 1.73 7.795 9.678 15.302 5.679 4.37 5.768 7.981 6.661 6.864 19.598 4.401 8.769 4.268 4.397 4.691 19.953 6.207 7.332 4.715 11.681 9.592 6.606 4.056 7.936 Itaconic acid 0.757 0.793 0.611 0.606 0.772 0.704 0.696 0.834 0.729 1.075 0.708 0.797 0.698 0.794 0.642 0.776 0.415 0.479 0.665 0.53 0.577 0.472 0.239 0.658 0.45 0.559 1.215 0.555 0.559 0.623 0.715 0.386 1.185 0.565 0.465 0.773 1.183 0.939 1.02 0.905 1.145 0.759 1.119 1.447 1.492 1.157 1.068 1.312 1.731 1.448 0.874 1.01 0.98 0.66 1.194 0.769 0.558 0.564 0.396 0.579 0.826 0.615 0.637 0.57 0.571 0.731 0.52 0.426 0.346 0.72 0.646 0.706 0.606 0.859 0.589 0.668 0.577 0.636 Lactic acid 73.638 90.072 74.703 69.027 80.621 84.961 78.928 69.145 74.282 91.166 68.769 82.505 85.421 75.571 59.165 70.688 53.882 63.343 89.636 78.319 65.014 53.077 33.871 75.271 53.004 69.012 98.49 84.279 34.762 77.5 77.888 50.65 55.005 33.96 25.594 39.339 43.466 50.585 50.418 46.777 41.704 46.228 41.198 49.317 52.839 48.214 46.828 43.175 56.617 62.518 34.473 54.413 44.183 28.838 50.649 38.256 38.354 33.552 19.884 36.545 32.098 35.138 28.713 38.754 27.798 35.86 31.233 25.47 29.455 41.966 34.001 29.631 32.533 31.287 33.567 35.162 24.828 35.964 Malic acid 75.286 87.18 63.216 60.467 87.457 63.267 90.464 81.686 83.385 124.801 62.474 86.824 79.494 86.458 56.956 91.074 52.392 70.89 99.443 80.048 69.216 56.329 30.629 104.967 54.947 76.69 149.214 98.784 47.793 93.126 104.48 52.658 40.977 29.898 26.493 36.575 66.919 40.15 50.328 55.427 61.062 70.407 60.906 58.042 92.472 80.456 61.384 86.712 112.59 85.06 51.942 75.446 75.225 40.847 60.069 32.757 29.61 35.743 25.9 47.106 55.679 47.826 39.706 29.819 47.968 36.008 35.452 35.921 27.211 41.218 40.01 41.843 39.721 58.756 37.41 42.853 43.025 35.714 NAD N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. 0.91 0.581 0.425 0.669 0.959 0.783 0.722 0.97 1.118 1.233 0.933 1.197 0.867 1.086 1.578 1.571 1.5 0.979 0.919 1.121 1.069 1.184 0.992 0.034 0.157 0.28 0.049 0.209 0.472 0.375 0.245 0.126 0.259 0.032 0.338 0.317 0.179 0.18 0.226 0.297 0.303 0.221 0.263 0.335 0.302 0.029 NADH N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. NADP N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. NADPH N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. Oxalacetic acid N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. Oxoglutaric acid N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. Phosphocreatine N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. Phosphoenolpyruvic acid N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. Pyruvic acid N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. Ribose 5-phosphate 23.798 26.904 21.887 20.803 26.442 17.31 19.946 23.958 22.615 29.209 16.895 30.52 20.327 24.841 14.669 21.614 19.968 27.279 36.198 24.938 30.807 17.558 14.132 27.027 19.595 25.098 38.049 24.571 15.849 32.63 33.134 19.639 25.55 20.27 15.464 15.081 29.462 27.696 24.367 25.024 22.814 24.04 20.182 24.809 34.908 21.818 30.069 26.967 50.635 29.827 23.438 29.117 33.805 17.758 27.142 16.053 17.237 15.387 10.08 11.17 17.007 16.936 13.101 22.774 17.597 16.454 13.811 14.247 11.077 30.368 12.886 14.239 15.619 28.118 18.231 17.326 13.848 15.961 Ribulose 5-phosphate N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. Sedoheptulose 7-phosphate 2.527 2.047 1.757 1.349 3.472 1.579 2.197 2.716 2.306 3.308 1.13 3.608 1.7 2.661 1.095 2.358 2.551 4.889 6.879 3.232 4.856 1.516 1.589 2.117 2.581 2.492 6.93 2.981 2.084 4.049 7.354 2.559 2.471 1.371 1.099 1.72 2.548 3.678 2.779 2.22 2.058 2.048 1.994 2.899 3.44 2.737 2.416 2.606 8.378 3.107 1.54 2.892 3.048 1.244 2.879 3.49 3.368 1.544 1.702 2.101 2.016 1.904 1.835 5.85 1.444 3.552 1.526 1.275 1.715 6.519 2.048 2.151 1.499 5.194 2.829 1.826 1.587 3.432 Serine N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. Succinic acid 32.297 36.011 26.996 24.893 40.065 33.988 36.952 36.164 32.642 42.241 28.25 31.776 39.573 44.529 30.595 33.192 11.151 9.392 19.757 27.894 10.896 15.794 3.069 30.134 10.894 20.272 44.421 25.171 5.977 19.425 18.026 10.689 35.612 27.346 25.767 40.601 45.459 22.962 41.185 40.313 39.833 40.776 43.766 39.587 55.384 55.167 40.229 53.858 63.694 47.08 28.567 53.077 48.913 28.288 41.935 29.518 25.699 30.48 21.749 36.097 37.621 31.451 27.277 14.096 30.175 28.801 27.051 27.191 24.433 21.858 34.667 29.551 27.923 13.876 21.58 29.101 35.277 27.671 Sum of Citric acid and Isocitric acid 10.236 12.166 13.739 13.751 10.437 13.606 8.926 13.549 12.435 17.555 9.173 15.511 15.345 15.507 17.772 12.098 10.804 9.165 14.304 15.405 16.199 15.72 5.557 18.194 14.399 18.409 14.979 10.258 3.491 18.63 12.259 12.095 20.212 19.431 20.085 16.161 30.043 29.269 21.395 21.4 28.233 24.868 21.77 27.225 33.991 23.365 31.791 29.43 30.645 30.471 27.275 15.448 30.234 21.401 27.536 20.637 7.963 13.651 10.773 9.508 16.521 7.371 5.95 7.792 7.762 19.643 6.979 12.421 3.447 13.364 5.579 6.774 7.994 17.873 8.561 14.093 12.703 9.34 U-13C10,U-15N5-Adenosine monophosphate N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. U-13C3-Pyruvic acid N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. U-13C6-Glucose 6-phosphate N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. Xylulose 5-phosphate N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. cis-Aconitic acid 0.09 0.083 0.094 0.127 0.159 0.123 0.145 0.194 0.078 0.179 0.169 0.159 0.142 0.099 0.12 0.089 0.076 0.081 0.141 0.082 0.088 0.106 0.102 0.154 0.101 0.143 0.083 0.107 0.078 0.178 0.12 0.092 N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. N.D. MS_METABOLITE_DATA_END #METABOLITES METABOLITES_START metabolite_name Expected RT MS1_mz MS2_mz 13C3-Citric acid 4.61 194.2 113 13C4-Fumaric acid 4.48 119.2 74.3 13C5-Itaconic acid 2.67 134 89.2 13C4-Malic acid 3.37 137.2 119.2 13C4-Succinic acid 2.32 121.3 76 13C5-Oxoglutaric acid 4.7 150.2 105.3 15N5-ADP 5.95 431.1 79 2-Hydroxyglutarate 2.9 145 101 2-Phosphoglyceric acid 5.66 185.5 97.1 3-Hydroxybutyric acid 2.17 103.2 59.2 3-Phosphoglyceric acid 5.67 185.5 97 6-Phosphogluconic acid 5.3 275 97 Acetoacetic acid 0.31 101 101 Adenosine monophosphate 3.9 346 79 Adenosine triphosphate 7 506.1 158.9 Adenosine triphosphate-d4 7 510 158.9 ADP 5.97 426.1 79 Alanine 2.18 88 88 Alanine-d4 2.07 92 92 Arginine 1.24 173 131 Arginine-d4C13 1.24 178 136 Asparagine 1.78 131 114 Aspartic acid 2.25 132 88 Aspartic acid-d3 2.25 135 91 cis-Aconitic acid 5.33 173 129 Sum of Citric acid and Isocitric acid 4.54 191.2 111 Dihydroxyacetone phosphate 4.55 169.1 79 Erythose 4-phosphate 4.36 199 97 Fructose 1,6-bisphosphate 5.51 339.1 79 Fructose 6-phosphate 4.5 259 97.1 Fumaric acid 4.7 115.2 71.3 Glucose 1-phosphate 4.5 259 241 Glucose 6-phosphate 4.5 259 97 Glutamic acid 1.9 146 128 Glutamic acid-d3 1.91 149 131 Glutamine 1.78 145 127 Glyceraldehyde 3-phosphate 4.55 169.1 97 Itaconic acid 2.67 129.2 85 Lactic acid 2.5 89.2 43.2 Malic acid 3.36 133.2 115.2 NAD 3.77 662.1 540.3 NADH 2.87 664.1 408.1 NADP 5.97 742.1 620 NADPH 4.73 744.1 408 Oxalacetic acid 3.63 131 131 Oxoglutaric acid 4.87 145.2 101.3 Phosphocreatine 3.53 210 79 Phosphoenolpyruvic acid 5.78 167 79 Pyruvic acid 4.64 87.2 43.2 Ribose 5-phosphate 4.54 229 97 Ribulose 5-phosphate 4.42 229 97.1 Sedoheptulose 7-phosphate 4.41 289 97 Serine 1.77 104 74 Succinic acid 2.28 117.2 73.2 U-13C10,U-15N5-Adenosine monophosphate 3.9 361 79 U-13C3-Pyruvic acid 4.64 90.2 45.2 U-13C6-Glucose 6-phosphate 4.4 265 97 Xylulose 5-phosphate 4.5 229.1 97 Fructose 1-phosphate 4.5 259.1 79 METABOLITES_END #END