#METABOLOMICS WORKBENCH Jung_DNLI_20250707_104749 DATATRACK_ID:6141 STUDY_ID:ST004059 ANALYSIS_ID:AN006716 PROJECT_ID:PR002548
VERSION             	1
CREATED_ON             	July 22, 2025, 11:13 am
#PROJECT
PR:PROJECT_TITLE                 	Lysosomal polyamine storage upon ATP13A2 loss impairs β-glucocerebrosidase via
PR:PROJECT_TITLE                 	altered lysosomal pH and electrostatic hydrolase-lipid interactions
PR:PROJECT_TYPE                  	Preclinical Mouse and cellular studies
PR:PROJECT_SUMMARY               	ATP13A2 is an endolysosomal polyamine transporter mutated in several
PR:PROJECT_SUMMARY               	neurodegenerative conditions involving lysosomal defects, including
PR:PROJECT_SUMMARY               	Parkinson’s disease (PD). While polyamines are polybasic and polycationic
PR:PROJECT_SUMMARY               	molecules that play pleiotropic cellular roles, their specific impact on
PR:PROJECT_SUMMARY               	lysosomal health is unknown. Here, we demonstrate lysosomal polyamine
PR:PROJECT_SUMMARY               	accumulation in ATP13A2 knockout (KO) cell lines. Primary polyamine storage
PR:PROJECT_SUMMARY               	caused secondary storage of lysosomal anionic phospholipid
PR:PROJECT_SUMMARY               	bis(monoacylglycero)phosphate (BMP) and age-dependent increase in the
PR:PROJECT_SUMMARY               	β-glucocerebrosidase (GCase) substrate, glucosylsphingosine, in Atp13a2 KO
PR:PROJECT_SUMMARY               	brains. Polyamine accumulation inhibited lysosomal GCase activity in cells and
PR:PROJECT_SUMMARY               	this was reversed by lysosome reacidification or BMP supplementation. A
PR:PROJECT_SUMMARY               	liposome-based GCase assay utilizing physiological substrates demonstrated
PR:PROJECT_SUMMARY               	dose-dependent inhibition of BMP-stimulated GCase activity by polyamines, in
PR:PROJECT_SUMMARY               	part via a pH-independent, electrostatics-based mechanism. Therefore, excess
PR:PROJECT_SUMMARY               	polyamine compromises lysosomes by disrupting pH and electrostatic interactions
PR:PROJECT_SUMMARY               	between GCase and BMP enabling efficient substrate hydrolysis, potentially
PR:PROJECT_SUMMARY               	clarifying their pathogenic mechanisms, and suggesting convergence on
PR:PROJECT_SUMMARY               	PD-relevant pathways.
PR:INSTITUTE                     	Denali Therapeutics
PR:LAST_NAME                     	Suh
PR:FIRST_NAME                    	Jung
PR:ADDRESS                       	161 Oyster Point Blvd, South San Francisco, California, 94080, USA
PR:EMAIL                         	suh@dnli.com
PR:PHONE                         	+1 06507973837
#STUDY
ST:STUDY_TITLE                   	Targeted Lipid and Metabolite Profiling in Brains of ATP13A2 Knockout Mice
ST:STUDY_SUMMARY                 	Comprehensive targeted profiling of lipids and metabolites was conducted in
ST:STUDY_SUMMARY                 	brain tissues from ATP13A2 knockout mice at 4.5 and 15 months of age to assess
ST:STUDY_SUMMARY                 	ATP13A2 deletion and its association with lysosomal dysfunction.
ST:INSTITUTE                     	Denali Therapeutics
ST:LAST_NAME                     	Suh
ST:FIRST_NAME                    	Jung
ST:ADDRESS                       	161 Oyster Point Blvd, South San Francisco, California, 94080, USA
ST:EMAIL                         	suh@dnli.com
ST:PHONE                         	+1 06507973837
#SUBJECT
SU:SUBJECT_TYPE                  	Mammal
SU:SUBJECT_SPECIES               	Mus musculus
SU:TAXONOMY_ID                   	10090
#SUBJECT_SAMPLE_FACTORS:         	SUBJECT(optional)[tab]SAMPLE[tab]FACTORS(NAME:VALUE pairs separated by |)[tab]Raw file names and additional sample data
SUBJECT_SAMPLE_FACTORS           	Pool_Cortex_001	HSA-000038800	genotype:WT | Sample source:brain	sex=NA; age=15; age_unit=month; region=Cortex; RAW_FILE_NAME(Raw Source Name.PITC)=20240607_MS_HEX-000817_PITC_Pos-20240607_MS_HEX-000817_Cortex_PITC_Pos_001.mzML; RAW_FILE_NAME(Raw Source Name.LP)=20240521_MS_HEX-000817_Lipid_Pos_001.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20240524_MS_HEX-000817_Lipid_Neg_001.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20240523_MS_HEX-000817_Met_Pos_001.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20240524_MS_HEX-000817_Met_Neg_001.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20240522_MS_HEX-000817_HALO_Pos_001.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20240528_MS_HEX-000817_GM_Neg_001.mzML
SUBJECT_SAMPLE_FACTORS           	Cortex_13	HSA-000038799	genotype:HOM KO ATP13A2 | Sample source:brain	sex=Male; age=15; age_unit=month; region=Cortex; RAW_FILE_NAME(Raw Source Name.PITC)=20240607_MS_HEX-000817_PITC_Pos-20240607_MS_HEX-000817_Cortex_PITC_Pos_002.mzML; RAW_FILE_NAME(Raw Source Name.LP)=20240521_MS_HEX-000817_Lipid_Pos_002.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20240524_MS_HEX-000817_Lipid_Neg_002.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20240523_MS_HEX-000817_Met_Pos_002.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20240524_MS_HEX-000817_Met_Neg_002.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20240522_MS_HEX-000817_HALO_Pos_002.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20240528_MS_HEX-000817_GM_Neg_002.mzML
SUBJECT_SAMPLE_FACTORS           	Cortex_08	HSA-000038794	genotype:HOM KO ATP13A2 | Sample source:brain	sex=Female; age=15; age_unit=month; region=Cortex; RAW_FILE_NAME(Raw Source Name.PITC)=20240607_MS_HEX-000817_PITC_Pos-20240607_MS_HEX-000817_Cortex_PITC_Pos_003.mzML; RAW_FILE_NAME(Raw Source Name.LP)=20240521_MS_HEX-000817_Lipid_Pos_003.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20240524_MS_HEX-000817_Lipid_Neg_003.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20240523_MS_HEX-000817_Met_Pos_003.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20240524_MS_HEX-000817_Met_Neg_003.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20240522_MS_HEX-000817_HALO_Pos_003.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20240528_MS_HEX-000817_GM_Neg_003.mzML
SUBJECT_SAMPLE_FACTORS           	Cortex_02	HSA-000038788	genotype:WT | Sample source:brain	sex=Male; age=15; age_unit=month; region=Cortex; RAW_FILE_NAME(Raw Source Name.PITC)=20240607_MS_HEX-000817_PITC_Pos-20240607_MS_HEX-000817_Cortex_PITC_Pos_004.mzML; RAW_FILE_NAME(Raw Source Name.LP)=20240521_MS_HEX-000817_Lipid_Pos_004.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20240524_MS_HEX-000817_Lipid_Neg_004.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20240523_MS_HEX-000817_Met_Pos_004.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20240524_MS_HEX-000817_Met_Neg_004.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20240522_MS_HEX-000817_HALO_Pos_004.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20240528_MS_HEX-000817_GM_Neg_004.mzML
SUBJECT_SAMPLE_FACTORS           	Cortex_11	HSA-000038797	genotype:HOM KO ATP13A2 | Sample source:brain	sex=Male; age=15; age_unit=month; region=Cortex; RAW_FILE_NAME(Raw Source Name.PITC)=20240607_MS_HEX-000817_PITC_Pos-20240607_MS_HEX-000817_Cortex_PITC_Pos_005.mzML; RAW_FILE_NAME(Raw Source Name.LP)=20240521_MS_HEX-000817_Lipid_Pos_005.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20240524_MS_HEX-000817_Lipid_Neg_005.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20240523_MS_HEX-000817_Met_Pos_005.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20240524_MS_HEX-000817_Met_Neg_005.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20240522_MS_HEX-000817_HALO_Pos_005.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20240528_MS_HEX-000817_GM_Neg_005.mzML
SUBJECT_SAMPLE_FACTORS           	Cortex_04	HSA-000038790	genotype:HOM KO ATP13A2 | Sample source:brain	sex=Male; age=15; age_unit=month; region=Cortex; RAW_FILE_NAME(Raw Source Name.PITC)=20240607_MS_HEX-000817_PITC_Pos-20240607_MS_HEX-000817_Cortex_PITC_Pos_006.mzML; RAW_FILE_NAME(Raw Source Name.LP)=20240521_MS_HEX-000817_Lipid_Pos_006.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20240524_MS_HEX-000817_Lipid_Neg_006.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20240523_MS_HEX-000817_Met_Pos_006.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20240524_MS_HEX-000817_Met_Neg_006.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20240522_MS_HEX-000817_HALO_Pos_006.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20240528_MS_HEX-000817_GM_Neg_006.mzML
SUBJECT_SAMPLE_FACTORS           	Cortex_12	HSA-000038798	genotype:WT | Sample source:brain	sex=Female; age=15; age_unit=month; region=Cortex; RAW_FILE_NAME(Raw Source Name.PITC)=20240607_MS_HEX-000817_PITC_Pos-20240607_MS_HEX-000817_Cortex_PITC_Pos_007.mzML; RAW_FILE_NAME(Raw Source Name.LP)=20240521_MS_HEX-000817_Lipid_Pos_007.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20240524_MS_HEX-000817_Lipid_Neg_007.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20240523_MS_HEX-000817_Met_Pos_007.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20240524_MS_HEX-000817_Met_Neg_007.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20240522_MS_HEX-000817_HALO_Pos_007.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20240528_MS_HEX-000817_GM_Neg_007.mzML
SUBJECT_SAMPLE_FACTORS           	Cortex_09	HSA-000038795	genotype:NA | Sample source:brain	sex=Male; age=15; age_unit=month; region=Cortex; RAW_FILE_NAME(Raw Source Name.PITC)=20240607_MS_HEX-000817_PITC_Pos-20240607_MS_HEX-000817_Cortex_PITC_Pos_008.mzML; RAW_FILE_NAME(Raw Source Name.LP)=20240521_MS_HEX-000817_Lipid_Pos_008.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20240524_MS_HEX-000817_Lipid_Neg_008.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20240523_MS_HEX-000817_Met_Pos_008.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20240524_MS_HEX-000817_Met_Neg_008.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20240522_MS_HEX-000817_HALO_Pos_008.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20240528_MS_HEX-000817_GM_Neg_008.mzML
SUBJECT_SAMPLE_FACTORS           	Pool_Cortex_002	HSA-000039091	genotype:HOM KO ATP13A2 | Sample source:brain	sex=NA; age=15; age_unit=month; region=Cortex; RAW_FILE_NAME(Raw Source Name.PITC)=20240607_MS_HEX-000817_PITC_Pos-20240607_MS_HEX-000817_Cortex_PITC_Pos_009.mzML; RAW_FILE_NAME(Raw Source Name.LP)=20240521_MS_HEX-000817_Lipid_Pos_009.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20240524_MS_HEX-000817_Lipid_Neg_009.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20240523_MS_HEX-000817_Met_Pos_009.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20240524_MS_HEX-000817_Met_Neg_009.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20240522_MS_HEX-000817_HALO_Pos_009.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20240528_MS_HEX-000817_GM_Neg_009.mzML
SUBJECT_SAMPLE_FACTORS           	Cortex_10	HSA-000038796	genotype:WT | Sample source:brain	sex=Female; age=15; age_unit=month; region=Cortex; RAW_FILE_NAME(Raw Source Name.PITC)=20240607_MS_HEX-000817_PITC_Pos-20240607_MS_HEX-000817_Cortex_PITC_Pos_010.mzML; RAW_FILE_NAME(Raw Source Name.LP)=20240521_MS_HEX-000817_Lipid_Pos_010.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20240524_MS_HEX-000817_Lipid_Neg_010.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20240523_MS_HEX-000817_Met_Pos_010.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20240524_MS_HEX-000817_Met_Neg_010.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20240522_MS_HEX-000817_HALO_Pos_010.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20240528_MS_HEX-000817_GM_Neg_010.mzML
SUBJECT_SAMPLE_FACTORS           	Cortex_05	HSA-000038791	genotype:WT | Sample source:brain	sex=Female; age=15; age_unit=month; region=Cortex; RAW_FILE_NAME(Raw Source Name.PITC)=20240607_MS_HEX-000817_PITC_Pos-20240607_MS_HEX-000817_Cortex_PITC_Pos_011.mzML; RAW_FILE_NAME(Raw Source Name.LP)=20240521_MS_HEX-000817_Lipid_Pos_011.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20240524_MS_HEX-000817_Lipid_Neg_011.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20240523_MS_HEX-000817_Met_Pos_011.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20240524_MS_HEX-000817_Met_Neg_011.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20240522_MS_HEX-000817_HALO_Pos_011.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20240528_MS_HEX-000817_GM_Neg_011.mzML
SUBJECT_SAMPLE_FACTORS           	Cortex_01	HSA-000038787	genotype:HOM KO ATP13A2 | Sample source:brain	sex=Female; age=15; age_unit=month; region=Cortex; RAW_FILE_NAME(Raw Source Name.PITC)=20240607_MS_HEX-000817_PITC_Pos-20240607_MS_HEX-000817_Cortex_PITC_Pos_012.mzML; RAW_FILE_NAME(Raw Source Name.LP)=20240521_MS_HEX-000817_Lipid_Pos_012.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20240524_MS_HEX-000817_Lipid_Neg_012.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20240523_MS_HEX-000817_Met_Pos_012.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20240524_MS_HEX-000817_Met_Neg_012.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20240522_MS_HEX-000817_HALO_Pos_012.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20240528_MS_HEX-000817_GM_Neg_012.mzML
SUBJECT_SAMPLE_FACTORS           	Cortex_06	HSA-000038792	genotype:WT | Sample source:brain	sex=Male; age=15; age_unit=month; region=Cortex; RAW_FILE_NAME(Raw Source Name.PITC)=20240607_MS_HEX-000817_PITC_Pos-20240607_MS_HEX-000817_Cortex_PITC_Pos_013.mzML; RAW_FILE_NAME(Raw Source Name.LP)=20240521_MS_HEX-000817_Lipid_Pos_013.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20240524_MS_HEX-000817_Lipid_Neg_013.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20240523_MS_HEX-000817_Met_Pos_013.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20240524_MS_HEX-000817_Met_Neg_013.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20240522_MS_HEX-000817_HALO_Pos_013.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20240528_MS_HEX-000817_GM_Neg_013.mzML
SUBJECT_SAMPLE_FACTORS           	Cortex_07	HSA-000038793	genotype:WT | Sample source:brain	sex=Male; age=15; age_unit=month; region=Cortex; RAW_FILE_NAME(Raw Source Name.PITC)=20240607_MS_HEX-000817_PITC_Pos-20240607_MS_HEX-000817_Cortex_PITC_Pos_014.mzML; RAW_FILE_NAME(Raw Source Name.LP)=20240521_MS_HEX-000817_Lipid_Pos_014.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20240524_MS_HEX-000817_Lipid_Neg_014.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20240523_MS_HEX-000817_Met_Pos_014.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20240524_MS_HEX-000817_Met_Neg_014.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20240522_MS_HEX-000817_HALO_Pos_014.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20240528_MS_HEX-000817_GM_Neg_014.mzML
SUBJECT_SAMPLE_FACTORS           	Cortex_03	HSA-000038789	genotype:NA | Sample source:brain	sex=Female; age=15; age_unit=month; region=Cortex; RAW_FILE_NAME(Raw Source Name.PITC)=20240607_MS_HEX-000817_PITC_Pos-20240607_MS_HEX-000817_Cortex_PITC_Pos_015.mzML; RAW_FILE_NAME(Raw Source Name.LP)=20240521_MS_HEX-000817_Lipid_Pos_015.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20240524_MS_HEX-000817_Lipid_Neg_015.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20240523_MS_HEX-000817_Met_Pos_015.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20240524_MS_HEX-000817_Met_Neg_015.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20240522_MS_HEX-000817_HALO_Pos_015.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20240528_MS_HEX-000817_GM_Neg_015.mzML
SUBJECT_SAMPLE_FACTORS           	Pool_Cortex_003	HSA-000039092	genotype:NA | Sample source:brain	sex=NA; age=15; age_unit=month; region=Cortex; RAW_FILE_NAME(Raw Source Name.PITC)=20240607_MS_HEX-000817_PITC_Pos-20240607_MS_HEX-000817_Cortex_PITC_Pos_016.mzML; RAW_FILE_NAME(Raw Source Name.LP)=20240521_MS_HEX-000817_Lipid_Pos_016.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20240524_MS_HEX-000817_Lipid_Neg_016.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20240523_MS_HEX-000817_Met_Pos_016.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20240524_MS_HEX-000817_Met_Neg_016.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20240522_MS_HEX-000817_HALO_Pos_016.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20240528_MS_HEX-000817_GM_Neg_016.mzML
SUBJECT_SAMPLE_FACTORS           	Pool_Hippo_001	HSA-000038814	genotype:WT | Sample source:brain	sex=NA; age=15; age_unit=month; region=Hippocampus; RAW_FILE_NAME(Raw Source Name.PITC)=20240607_MS_HEX-000817_PITC_Pos-20240607_MS_HEX-000817_HippC_PITC_Pos_002; RAW_FILE_NAME(Raw Source Name.LP)=20240521_MS_HEX-000817_Lipid_Pos_017.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20240524_MS_HEX-000817_Lipid_Neg_017.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20240523_MS_HEX-000817_Met_Pos_017.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20240524_MS_HEX-000817_Met_Neg_017.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20240522_MS_HEX-000817_HALO_Pos_017.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20240528_MS_HEX-000817_GM_Neg_017.mzML
SUBJECT_SAMPLE_FACTORS           	Hipp_13	HSA-000038813	genotype:WT | Sample source:brain	sex=Male; age=15; age_unit=month; region=Hippocampus; RAW_FILE_NAME(Raw Source Name.PITC)=20240607_MS_HEX-000817_PITC_Pos-20240607_MS_HEX-000817_HippC_PITC_Pos_003; RAW_FILE_NAME(Raw Source Name.LP)=20240521_MS_HEX-000817_Lipid_Pos_018.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20240524_MS_HEX-000817_Lipid_Neg_018.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20240523_MS_HEX-000817_Met_Pos_018.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20240524_MS_HEX-000817_Met_Neg_018.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20240522_MS_HEX-000817_HALO_Pos_018.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20240528_MS_HEX-000817_GM_Neg_018.mzML
SUBJECT_SAMPLE_FACTORS           	Hipp_11	HSA-000038811	genotype:HOM KO ATP13A2 | Sample source:brain	sex=Male; age=15; age_unit=month; region=Hippocampus; RAW_FILE_NAME(Raw Source Name.PITC)=20240607_MS_HEX-000817_PITC_Pos-20240607_MS_HEX-000817_HippC_PITC_Pos_004; RAW_FILE_NAME(Raw Source Name.LP)=20240521_MS_HEX-000817_Lipid_Pos_019.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20240524_MS_HEX-000817_Lipid_Neg_019.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20240523_MS_HEX-000817_Met_Pos_019.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20240524_MS_HEX-000817_Met_Neg_019.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20240522_MS_HEX-000817_HALO_Pos_019.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20240528_MS_HEX-000817_GM_Neg_019.mzML
SUBJECT_SAMPLE_FACTORS           	Hipp_04	HSA-000038804	genotype:WT | Sample source:brain	sex=Male; age=15; age_unit=month; region=Hippocampus; RAW_FILE_NAME(Raw Source Name.PITC)=20240607_MS_HEX-000817_PITC_Pos-20240607_MS_HEX-000817_HippC_PITC_Pos_005; RAW_FILE_NAME(Raw Source Name.LP)=20240521_MS_HEX-000817_Lipid_Pos_020.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20240524_MS_HEX-000817_Lipid_Neg_020.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20240523_MS_HEX-000817_Met_Pos_020.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20240524_MS_HEX-000817_Met_Neg_020.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20240522_MS_HEX-000817_HALO_Pos_020.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20240528_MS_HEX-000817_GM_Neg_020.mzML
SUBJECT_SAMPLE_FACTORS           	Hipp_05	HSA-000038805	genotype:WT | Sample source:brain	sex=Female; age=15; age_unit=month; region=Hippocampus; RAW_FILE_NAME(Raw Source Name.PITC)=20240607_MS_HEX-000817_PITC_Pos-20240607_MS_HEX-000817_HippC_PITC_Pos_006; RAW_FILE_NAME(Raw Source Name.LP)=20240521_MS_HEX-000817_Lipid_Pos_021.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20240524_MS_HEX-000817_Lipid_Neg_021.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20240523_MS_HEX-000817_Met_Pos_021.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20240524_MS_HEX-000817_Met_Neg_021.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20240522_MS_HEX-000817_HALO_Pos_021.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20240528_MS_HEX-000817_GM_Neg_021.mzML
SUBJECT_SAMPLE_FACTORS           	Hipp_03	HSA-000038803	genotype:HOM KO ATP13A2 | Sample source:brain	sex=Female; age=15; age_unit=month; region=Hippocampus; RAW_FILE_NAME(Raw Source Name.PITC)=20240607_MS_HEX-000817_PITC_Pos-20240607_MS_HEX-000817_HippC_PITC_Pos_007; RAW_FILE_NAME(Raw Source Name.LP)=20240521_MS_HEX-000817_Lipid_Pos_022.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20240524_MS_HEX-000817_Lipid_Neg_022.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20240523_MS_HEX-000817_Met_Pos_022.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20240524_MS_HEX-000817_Met_Neg_022.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20240522_MS_HEX-000817_HALO_Pos_022.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20240528_MS_HEX-000817_GM_Neg_022.mzML
SUBJECT_SAMPLE_FACTORS           	Hipp_02	HSA-000038802	genotype:WT | Sample source:brain	sex=Male; age=15; age_unit=month; region=Hippocampus; RAW_FILE_NAME(Raw Source Name.PITC)=20240607_MS_HEX-000817_PITC_Pos-20240607_MS_HEX-000817_HippC_PITC_Pos_008; RAW_FILE_NAME(Raw Source Name.LP)=20240521_MS_HEX-000817_Lipid_Pos_023.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20240524_MS_HEX-000817_Lipid_Neg_023.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20240523_MS_HEX-000817_Met_Pos_023.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20240524_MS_HEX-000817_Met_Neg_023.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20240522_MS_HEX-000817_HALO_Pos_023.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20240528_MS_HEX-000817_GM_Neg_023.mzML
SUBJECT_SAMPLE_FACTORS           	Hipp_07	HSA-000038807	genotype:NA | Sample source:brain	sex=Male; age=15; age_unit=month; region=Hippocampus; RAW_FILE_NAME(Raw Source Name.PITC)=20240607_MS_HEX-000817_PITC_Pos-20240607_MS_HEX-000817_HippC_PITC_Pos_009; RAW_FILE_NAME(Raw Source Name.LP)=20240521_MS_HEX-000817_Lipid_Pos_024.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20240524_MS_HEX-000817_Lipid_Neg_024.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20240523_MS_HEX-000817_Met_Pos_024.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20240524_MS_HEX-000817_Met_Neg_024.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20240522_MS_HEX-000817_HALO_Pos_024.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20240528_MS_HEX-000817_GM_Neg_024.mzML
SUBJECT_SAMPLE_FACTORS           	Pool_Hippo_002	HSA-000039093	genotype:WT | Sample source:brain	sex=NA; age=15; age_unit=month; region=Hippocampus; RAW_FILE_NAME(Raw Source Name.PITC)=20240607_MS_HEX-000817_PITC_Pos-20240607_MS_HEX-000817_HippC_PITC_Pos_010; RAW_FILE_NAME(Raw Source Name.LP)=20240521_MS_HEX-000817_Lipid_Pos_025.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20240524_MS_HEX-000817_Lipid_Neg_025.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20240523_MS_HEX-000817_Met_Pos_025.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20240524_MS_HEX-000817_Met_Neg_025.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20240522_MS_HEX-000817_HALO_Pos_025.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20240528_MS_HEX-000817_GM_Neg_025.mzML
SUBJECT_SAMPLE_FACTORS           	Hipp_09	HSA-000038809	genotype:HOM KO ATP13A2 | Sample source:brain	sex=Male; age=15; age_unit=month; region=Hippocampus; RAW_FILE_NAME(Raw Source Name.PITC)=20240607_MS_HEX-000817_PITC_Pos-20240607_MS_HEX-000817_HippC_PITC_Pos_011; RAW_FILE_NAME(Raw Source Name.LP)=20240521_MS_HEX-000817_Lipid_Pos_026.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20240524_MS_HEX-000817_Lipid_Neg_026.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20240523_MS_HEX-000817_Met_Pos_026.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20240524_MS_HEX-000817_Met_Neg_026.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20240522_MS_HEX-000817_HALO_Pos_026.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20240528_MS_HEX-000817_GM_Neg_026.mzML
SUBJECT_SAMPLE_FACTORS           	Hipp_12	HSA-000038812	genotype:HOM KO ATP13A2 | Sample source:brain	sex=Female; age=15; age_unit=month; region=Hippocampus; RAW_FILE_NAME(Raw Source Name.PITC)=20240607_MS_HEX-000817_PITC_Pos-20240607_MS_HEX-000817_HippC_PITC_Pos_012; RAW_FILE_NAME(Raw Source Name.LP)=20240521_MS_HEX-000817_Lipid_Pos_027.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20240524_MS_HEX-000817_Lipid_Neg_027.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20240523_MS_HEX-000817_Met_Pos_027.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20240524_MS_HEX-000817_Met_Neg_027.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20240522_MS_HEX-000817_HALO_Pos_027.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20240528_MS_HEX-000817_GM_Neg_027.mzML
SUBJECT_SAMPLE_FACTORS           	Hipp_06	HSA-000038806	genotype:WT | Sample source:brain	sex=Male; age=15; age_unit=month; region=Hippocampus; RAW_FILE_NAME(Raw Source Name.PITC)=20240607_MS_HEX-000817_PITC_Pos-20240607_MS_HEX-000817_HippC_PITC_Pos_013; RAW_FILE_NAME(Raw Source Name.LP)=20240521_MS_HEX-000817_Lipid_Pos_028.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20240524_MS_HEX-000817_Lipid_Neg_028.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20240523_MS_HEX-000817_Met_Pos_028.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20240524_MS_HEX-000817_Met_Neg_028.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20240522_MS_HEX-000817_HALO_Pos_028.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20240528_MS_HEX-000817_GM_Neg_028.mzML
SUBJECT_SAMPLE_FACTORS           	Hipp_01	HSA-000038801	genotype:HOM KO ATP13A2 | Sample source:brain	sex=Female; age=15; age_unit=month; region=Hippocampus; RAW_FILE_NAME(Raw Source Name.PITC)=20240607_MS_HEX-000817_PITC_Pos-20240607_MS_HEX-000817_HippC_PITC_Pos_014; RAW_FILE_NAME(Raw Source Name.LP)=20240521_MS_HEX-000817_Lipid_Pos_029.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20240524_MS_HEX-000817_Lipid_Neg_029.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20240523_MS_HEX-000817_Met_Pos_029.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20240524_MS_HEX-000817_Met_Neg_029.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20240522_MS_HEX-000817_HALO_Pos_029.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20240528_MS_HEX-000817_GM_Neg_029.mzML
SUBJECT_SAMPLE_FACTORS           	Hipp_10	HSA-000038810	genotype:HOM KO ATP13A2 | Sample source:brain	sex=Female; age=15; age_unit=month; region=Hippocampus; RAW_FILE_NAME(Raw Source Name.PITC)=20240607_MS_HEX-000817_PITC_Pos-20240607_MS_HEX-000817_HippC_PITC_Pos_015; RAW_FILE_NAME(Raw Source Name.LP)=20240521_MS_HEX-000817_Lipid_Pos_030.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20240524_MS_HEX-000817_Lipid_Neg_030.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20240523_MS_HEX-000817_Met_Pos_030.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20240524_MS_HEX-000817_Met_Neg_030.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20240522_MS_HEX-000817_HALO_Pos_030.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20240528_MS_HEX-000817_GM_Neg_030.mzML
SUBJECT_SAMPLE_FACTORS           	Hipp_08	HSA-000038808	genotype:NA | Sample source:brain	sex=Female; age=15; age_unit=month; region=Hippocampus; RAW_FILE_NAME(Raw Source Name.PITC)=20240607_MS_HEX-000817_PITC_Pos-20240607_MS_HEX-000817_HippC_PITC_Pos_016; RAW_FILE_NAME(Raw Source Name.LP)=20240521_MS_HEX-000817_Lipid_Pos_031.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20240524_MS_HEX-000817_Lipid_Neg_031.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20240523_MS_HEX-000817_Met_Pos_031.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20240524_MS_HEX-000817_Met_Neg_031.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20240522_MS_HEX-000817_HALO_Pos_031.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20240528_MS_HEX-000817_GM_Neg_031.mzML
SUBJECT_SAMPLE_FACTORS           	Pool_Hippo_003	HSA-000039094	genotype:NA | Sample source:brain	sex=NA; age=15; age_unit=month; region=Hippocampus; RAW_FILE_NAME(Raw Source Name.PITC)=20240607_MS_HEX-000817_PITC_Pos-20240607_MS_HEX-000817_HippC_PITC_Pos_017; RAW_FILE_NAME(Raw Source Name.LP)=20240521_MS_HEX-000817_Lipid_Pos_032.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20240524_MS_HEX-000817_Lipid_Neg_032.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20240523_MS_HEX-000817_Met_Pos_032.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20240524_MS_HEX-000817_Met_Neg_032.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20240522_MS_HEX-000817_HALO_Pos_032.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20240528_MS_HEX-000817_GM_Neg_032.mzML
SUBJECT_SAMPLE_FACTORS           	Cortex_pool-1	HSA-000034484	genotype:NA | Sample source:brain	sex=NA; age=4.5; age_unit=month; region=Cortex; RAW_FILE_NAME(Raw Source Name.PITC)=20231013_MS_HEX-000681_PITC_Pos-20231013_MS_HEX-000681_Cortex_PITC_Pos_001.mzML; RAW_FILE_NAME(Raw Source Name.LP)=20231006_MS_HEX-000681_Lipid_Pos-20231006_MS_HEX-000681_Cortex_Lipid_Pos_001.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20231008_MS_HEX-000681_Lipid_Neg-20231008_MS_HEX-000681_Cortex_Lipid_Neg_001.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20231007_MS_HEX-000681_Met_Pos-20231007_MS_HEX-000681_Cortex_Met_Pos_001.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20231008_MS_HEX-000681_Met_Neg-20231008_MS_HEX-000681_Cortex_Met_Neg_001.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20231007_MS_HEX-000681_HALO_Pos-20231007_MS_HEX-000681_Cortex_HALO_Pos_001.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20231010_MS_HEX-000681_GM_Neg-20231010_MS_HEX-000681_Cortex_GM_Neg_001.mzML
SUBJECT_SAMPLE_FACTORS           	Cortex_09	HSA-000034472	genotype:HET KO ATP13A2 | Sample source:brain	sex=Male; age=4.5; age_unit=month; region=Cortex; RAW_FILE_NAME(Raw Source Name.PITC)=20231013_MS_HEX-000681_PITC_Pos-20231013_MS_HEX-000681_Cortex_PITC_Pos_002.mzML; RAW_FILE_NAME(Raw Source Name.LP)=20231006_MS_HEX-000681_Lipid_Pos-20231006_MS_HEX-000681_Cortex_Lipid_Pos_002.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20231008_MS_HEX-000681_Lipid_Neg-20231008_MS_HEX-000681_Cortex_Lipid_Neg_002.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20231007_MS_HEX-000681_Met_Pos-20231007_MS_HEX-000681_Cortex_Met_Pos_002.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20231008_MS_HEX-000681_Met_Neg-20231008_MS_HEX-000681_Cortex_Met_Neg_002.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20231007_MS_HEX-000681_HALO_Pos-20231007_MS_HEX-000681_Cortex_HALO_Pos_002.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20231010_MS_HEX-000681_GM_Neg-20231010_MS_HEX-000681_Cortex_GM_Neg_002.mzML
SUBJECT_SAMPLE_FACTORS           	Cortex_07	HSA-000034470	genotype:WT | Sample source:brain	sex=Male; age=4.5; age_unit=month; region=Cortex; RAW_FILE_NAME(Raw Source Name.PITC)=20231013_MS_HEX-000681_PITC_Pos-20231013_MS_HEX-000681_Cortex_PITC_Pos_003.mzML; RAW_FILE_NAME(Raw Source Name.LP)=20231006_MS_HEX-000681_Lipid_Pos-20231006_MS_HEX-000681_Cortex_Lipid_Pos_003.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20231008_MS_HEX-000681_Lipid_Neg-20231008_MS_HEX-000681_Cortex_Lipid_Neg_003.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20231007_MS_HEX-000681_Met_Pos-20231007_MS_HEX-000681_Cortex_Met_Pos_003.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20231008_MS_HEX-000681_Met_Neg-20231008_MS_HEX-000681_Cortex_Met_Neg_003.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20231007_MS_HEX-000681_HALO_Pos-20231007_MS_HEX-000681_Cortex_HALO_Pos_003.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20231010_MS_HEX-000681_GM_Neg-20231010_MS_HEX-000681_Cortex_GM_Neg_003.mzML
SUBJECT_SAMPLE_FACTORS           	Cortex_16	HSA-000034479	genotype:WT | Sample source:brain	sex=Female; age=4.5; age_unit=month; region=Cortex; RAW_FILE_NAME(Raw Source Name.PITC)=20231013_MS_HEX-000681_PITC_Pos-20231013_MS_HEX-000681_Cortex_PITC_Pos_004.mzML; RAW_FILE_NAME(Raw Source Name.LP)=20231006_MS_HEX-000681_Lipid_Pos-20231006_MS_HEX-000681_Cortex_Lipid_Pos_004.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20231008_MS_HEX-000681_Lipid_Neg-20231008_MS_HEX-000681_Cortex_Lipid_Neg_004.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20231007_MS_HEX-000681_Met_Pos-20231007_MS_HEX-000681_Cortex_Met_Pos_004.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20231008_MS_HEX-000681_Met_Neg-20231008_MS_HEX-000681_Cortex_Met_Neg_004.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20231007_MS_HEX-000681_HALO_Pos-20231007_MS_HEX-000681_Cortex_HALO_Pos_004.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20231010_MS_HEX-000681_GM_Neg-20231010_MS_HEX-000681_Cortex_GM_Neg_004.mzML
SUBJECT_SAMPLE_FACTORS           	Cortex_04	HSA-000034467	genotype:WT | Sample source:brain	sex=Female; age=4.5; age_unit=month; region=Cortex; RAW_FILE_NAME(Raw Source Name.PITC)=20231013_MS_HEX-000681_PITC_Pos-20231013_MS_HEX-000681_Cortex_PITC_Pos_005.mzML; RAW_FILE_NAME(Raw Source Name.LP)=20231006_MS_HEX-000681_Lipid_Pos-20231006_MS_HEX-000681_Cortex_Lipid_Pos_005.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20231008_MS_HEX-000681_Lipid_Neg-20231008_MS_HEX-000681_Cortex_Lipid_Neg_005.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20231007_MS_HEX-000681_Met_Pos-20231007_MS_HEX-000681_Cortex_Met_Pos_005.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20231008_MS_HEX-000681_Met_Neg-20231008_MS_HEX-000681_Cortex_Met_Neg_005.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20231007_MS_HEX-000681_HALO_Pos-20231007_MS_HEX-000681_Cortex_HALO_Pos_005.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20231010_MS_HEX-000681_GM_Neg-20231010_MS_HEX-000681_Cortex_GM_Neg_005.mzML
SUBJECT_SAMPLE_FACTORS           	Cortex_20	HSA-000034483	genotype:HOM KO ATP13A2 | Sample source:brain	sex=Female; age=4.5; age_unit=month; region=Cortex; RAW_FILE_NAME(Raw Source Name.PITC)=20231013_MS_HEX-000681_PITC_Pos-20231013_MS_HEX-000681_Cortex_PITC_Pos_006.mzML; RAW_FILE_NAME(Raw Source Name.LP)=20231006_MS_HEX-000681_Lipid_Pos-20231006_MS_HEX-000681_Cortex_Lipid_Pos_006.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20231008_MS_HEX-000681_Lipid_Neg-20231008_MS_HEX-000681_Cortex_Lipid_Neg_006.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20231007_MS_HEX-000681_Met_Pos-20231007_MS_HEX-000681_Cortex_Met_Pos_006.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20231008_MS_HEX-000681_Met_Neg-20231008_MS_HEX-000681_Cortex_Met_Neg_006.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20231007_MS_HEX-000681_HALO_Pos-20231007_MS_HEX-000681_Cortex_HALO_Pos_006.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20231010_MS_HEX-000681_GM_Neg-20231010_MS_HEX-000681_Cortex_GM_Neg_006.mzML
SUBJECT_SAMPLE_FACTORS           	Cortex_18	HSA-000034481	genotype:HET KO ATP13A2 | Sample source:brain	sex=Female; age=4.5; age_unit=month; region=Cortex; RAW_FILE_NAME(Raw Source Name.PITC)=20231013_MS_HEX-000681_PITC_Pos-20231013_MS_HEX-000681_Cortex_PITC_Pos_007.mzML; RAW_FILE_NAME(Raw Source Name.LP)=20231006_MS_HEX-000681_Lipid_Pos-20231006_MS_HEX-000681_Cortex_Lipid_Pos_007.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20231008_MS_HEX-000681_Lipid_Neg-20231008_MS_HEX-000681_Cortex_Lipid_Neg_007.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20231007_MS_HEX-000681_Met_Pos-20231007_MS_HEX-000681_Cortex_Met_Pos_007.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20231008_MS_HEX-000681_Met_Neg-20231008_MS_HEX-000681_Cortex_Met_Neg_007.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20231007_MS_HEX-000681_HALO_Pos-20231007_MS_HEX-000681_Cortex_HALO_Pos_007.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20231010_MS_HEX-000681_GM_Neg-20231010_MS_HEX-000681_Cortex_GM_Neg_007.mzML
SUBJECT_SAMPLE_FACTORS           	Cortex_15	HSA-000034478	genotype:HET KO ATP13A2 | Sample source:brain	sex=Male; age=4.5; age_unit=month; region=Cortex; RAW_FILE_NAME(Raw Source Name.PITC)=20231013_MS_HEX-000681_PITC_Pos-20231013_MS_HEX-000681_Cortex_PITC_Pos_008.mzML; RAW_FILE_NAME(Raw Source Name.LP)=20231006_MS_HEX-000681_Lipid_Pos-20231006_MS_HEX-000681_Cortex_Lipid_Pos_008.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20231008_MS_HEX-000681_Lipid_Neg-20231008_MS_HEX-000681_Cortex_Lipid_Neg_008.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20231007_MS_HEX-000681_Met_Pos-20231007_MS_HEX-000681_Cortex_Met_Pos_008.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20231008_MS_HEX-000681_Met_Neg-20231008_MS_HEX-000681_Cortex_Met_Neg_008.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20231007_MS_HEX-000681_HALO_Pos-20231007_MS_HEX-000681_Cortex_HALO_Pos_008.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20231010_MS_HEX-000681_GM_Neg-20231010_MS_HEX-000681_Cortex_GM_Neg_008.mzML
SUBJECT_SAMPLE_FACTORS           	Cortex_08	HSA-000034471	genotype:HOM KO ATP13A2 | Sample source:brain	sex=Female; age=4.5; age_unit=month; region=Cortex; RAW_FILE_NAME(Raw Source Name.PITC)=20231013_MS_HEX-000681_PITC_Pos-20231013_MS_HEX-000681_Cortex_PITC_Pos_009.mzML; RAW_FILE_NAME(Raw Source Name.LP)=20231006_MS_HEX-000681_Lipid_Pos-20231006_MS_HEX-000681_Cortex_Lipid_Pos_009.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20231008_MS_HEX-000681_Lipid_Neg-20231008_MS_HEX-000681_Cortex_Lipid_Neg_009.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20231007_MS_HEX-000681_Met_Pos-20231007_MS_HEX-000681_Cortex_Met_Pos_009.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20231008_MS_HEX-000681_Met_Neg-20231008_MS_HEX-000681_Cortex_Met_Neg_009.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20231007_MS_HEX-000681_HALO_Pos-20231007_MS_HEX-000681_Cortex_HALO_Pos_009.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20231010_MS_HEX-000681_GM_Neg-20231010_MS_HEX-000681_Cortex_GM_Neg_009.mzML
SUBJECT_SAMPLE_FACTORS           	Cortex_03	HSA-000034466	genotype:HET KO ATP13A2 | Sample source:brain	sex=Male; age=4.5; age_unit=month; region=Cortex; RAW_FILE_NAME(Raw Source Name.PITC)=20231013_MS_HEX-000681_PITC_Pos-20231013_MS_HEX-000681_Cortex_PITC_Pos_010.mzML; RAW_FILE_NAME(Raw Source Name.LP)=20231006_MS_HEX-000681_Lipid_Pos-20231006_MS_HEX-000681_Cortex_Lipid_Pos_010.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20231008_MS_HEX-000681_Lipid_Neg-20231008_MS_HEX-000681_Cortex_Lipid_Neg_010.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20231007_MS_HEX-000681_Met_Pos-20231007_MS_HEX-000681_Cortex_Met_Pos_010.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20231008_MS_HEX-000681_Met_Neg-20231008_MS_HEX-000681_Cortex_Met_Neg_010.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20231007_MS_HEX-000681_HALO_Pos-20231007_MS_HEX-000681_Cortex_HALO_Pos_010.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20231010_MS_HEX-000681_GM_Neg-20231010_MS_HEX-000681_Cortex_GM_Neg_010.mzML
SUBJECT_SAMPLE_FACTORS           	Cortex_14	HSA-000034477	genotype:HOM KO ATP13A2 | Sample source:brain	sex=Female; age=4.5; age_unit=month; region=Cortex; RAW_FILE_NAME(Raw Source Name.PITC)=20231013_MS_HEX-000681_PITC_Pos-20231013_MS_HEX-000681_Cortex_PITC_Pos_011.mzML; RAW_FILE_NAME(Raw Source Name.LP)=20231006_MS_HEX-000681_Lipid_Pos-20231006_MS_HEX-000681_Cortex_Lipid_Pos_011.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20231008_MS_HEX-000681_Lipid_Neg-20231008_MS_HEX-000681_Cortex_Lipid_Neg_011.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20231007_MS_HEX-000681_Met_Pos-20231007_MS_HEX-000681_Cortex_Met_Pos_011.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20231008_MS_HEX-000681_Met_Neg-20231008_MS_HEX-000681_Cortex_Met_Neg_011.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20231007_MS_HEX-000681_HALO_Pos-20231007_MS_HEX-000681_Cortex_HALO_Pos_011.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20231010_MS_HEX-000681_GM_Neg-20231010_MS_HEX-000681_Cortex_GM_Neg_011.mzML
SUBJECT_SAMPLE_FACTORS           	Cortex_pool-2	HSA-000035023	genotype:NA | Sample source:brain	sex=NA; age=4.5; age_unit=month; region=Cortex; RAW_FILE_NAME(Raw Source Name.PITC)=20231013_MS_HEX-000681_PITC_Pos-20231013_MS_HEX-000681_Cortex_PITC_Pos_012.mzML; RAW_FILE_NAME(Raw Source Name.LP)=20231006_MS_HEX-000681_Lipid_Pos-20231006_MS_HEX-000681_Cortex_Lipid_Pos_012.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20231008_MS_HEX-000681_Lipid_Neg-20231008_MS_HEX-000681_Cortex_Lipid_Neg_012.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20231007_MS_HEX-000681_Met_Pos-20231007_MS_HEX-000681_Cortex_Met_Pos_012.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20231008_MS_HEX-000681_Met_Neg-20231008_MS_HEX-000681_Cortex_Met_Neg_012.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20231007_MS_HEX-000681_HALO_Pos-20231007_MS_HEX-000681_Cortex_HALO_Pos_012.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20231010_MS_HEX-000681_GM_Neg-20231010_MS_HEX-000681_Cortex_GM_Neg_012.mzML
SUBJECT_SAMPLE_FACTORS           	Cortex_17	HSA-000034480	genotype:HOM KO ATP13A2 | Sample source:brain	sex=Female; age=4.5; age_unit=month; region=Cortex; RAW_FILE_NAME(Raw Source Name.PITC)=20231013_MS_HEX-000681_PITC_Pos-20231013_MS_HEX-000681_Cortex_PITC_Pos_013.mzML; RAW_FILE_NAME(Raw Source Name.LP)=20231006_MS_HEX-000681_Lipid_Pos-20231006_MS_HEX-000681_Cortex_Lipid_Pos_013.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20231008_MS_HEX-000681_Lipid_Neg-20231008_MS_HEX-000681_Cortex_Lipid_Neg_013.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20231007_MS_HEX-000681_Met_Pos-20231007_MS_HEX-000681_Cortex_Met_Pos_013.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20231008_MS_HEX-000681_Met_Neg-20231008_MS_HEX-000681_Cortex_Met_Neg_013.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20231007_MS_HEX-000681_HALO_Pos-20231007_MS_HEX-000681_Cortex_HALO_Pos_013.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20231010_MS_HEX-000681_GM_Neg-20231010_MS_HEX-000681_Cortex_GM_Neg_013.mzML
SUBJECT_SAMPLE_FACTORS           	Cortex_11	HSA-000034474	genotype:HOM KO ATP13A2 | Sample source:brain	sex=Female; age=4.5; age_unit=month; region=Cortex; RAW_FILE_NAME(Raw Source Name.PITC)=20231013_MS_HEX-000681_PITC_Pos-20231013_MS_HEX-000681_Cortex_PITC_Pos_014.mzML; RAW_FILE_NAME(Raw Source Name.LP)=20231006_MS_HEX-000681_Lipid_Pos-20231006_MS_HEX-000681_Cortex_Lipid_Pos_014.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20231008_MS_HEX-000681_Lipid_Neg-20231008_MS_HEX-000681_Cortex_Lipid_Neg_014.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20231007_MS_HEX-000681_Met_Pos-20231007_MS_HEX-000681_Cortex_Met_Pos_014.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20231008_MS_HEX-000681_Met_Neg-20231008_MS_HEX-000681_Cortex_Met_Neg_014.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20231007_MS_HEX-000681_HALO_Pos-20231007_MS_HEX-000681_Cortex_HALO_Pos_014.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20231010_MS_HEX-000681_GM_Neg-20231010_MS_HEX-000681_Cortex_GM_Neg_014.mzML
SUBJECT_SAMPLE_FACTORS           	Cortex_12	HSA-000034475	genotype:HET KO ATP13A2 | Sample source:brain	sex=Male; age=4.5; age_unit=month; region=Cortex; RAW_FILE_NAME(Raw Source Name.PITC)=20231013_MS_HEX-000681_PITC_Pos-20231013_MS_HEX-000681_Cortex_PITC_Pos_015.mzML; RAW_FILE_NAME(Raw Source Name.LP)=20231006_MS_HEX-000681_Lipid_Pos-20231006_MS_HEX-000681_Cortex_Lipid_Pos_015.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20231008_MS_HEX-000681_Lipid_Neg-20231008_MS_HEX-000681_Cortex_Lipid_Neg_015.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20231007_MS_HEX-000681_Met_Pos-20231007_MS_HEX-000681_Cortex_Met_Pos_015.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20231008_MS_HEX-000681_Met_Neg-20231008_MS_HEX-000681_Cortex_Met_Neg_015.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20231007_MS_HEX-000681_HALO_Pos-20231007_MS_HEX-000681_Cortex_HALO_Pos_015.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20231010_MS_HEX-000681_GM_Neg-20231010_MS_HEX-000681_Cortex_GM_Neg_015.mzML
SUBJECT_SAMPLE_FACTORS           	Cortex_01	HSA-000034464	genotype:WT | Sample source:brain	sex=Female; age=4.5; age_unit=month; region=Cortex; RAW_FILE_NAME(Raw Source Name.PITC)=20231013_MS_HEX-000681_PITC_Pos-20231013_MS_HEX-000681_Cortex_PITC_Pos_016.mzML; RAW_FILE_NAME(Raw Source Name.LP)=20231006_MS_HEX-000681_Lipid_Pos-20231006_MS_HEX-000681_Cortex_Lipid_Pos_016.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20231008_MS_HEX-000681_Lipid_Neg-20231008_MS_HEX-000681_Cortex_Lipid_Neg_016.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20231007_MS_HEX-000681_Met_Pos-20231007_MS_HEX-000681_Cortex_Met_Pos_016.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20231008_MS_HEX-000681_Met_Neg-20231008_MS_HEX-000681_Cortex_Met_Neg_016.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20231007_MS_HEX-000681_HALO_Pos-20231007_MS_HEX-000681_Cortex_HALO_Pos_016.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20231010_MS_HEX-000681_GM_Neg-20231010_MS_HEX-000681_Cortex_GM_Neg_016.mzML
SUBJECT_SAMPLE_FACTORS           	Cortex_13	HSA-000034476	genotype:WT | Sample source:brain	sex=Male; age=4.5; age_unit=month; region=Cortex; RAW_FILE_NAME(Raw Source Name.PITC)=20231013_MS_HEX-000681_PITC_Pos-20231013_MS_HEX-000681_Cortex_PITC_Pos_017.mzML; RAW_FILE_NAME(Raw Source Name.LP)=20231006_MS_HEX-000681_Lipid_Pos-20231006_MS_HEX-000681_Cortex_Lipid_Pos_017.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20231008_MS_HEX-000681_Lipid_Neg-20231008_MS_HEX-000681_Cortex_Lipid_Neg_017.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20231007_MS_HEX-000681_Met_Pos-20231007_MS_HEX-000681_Cortex_Met_Pos_017.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20231008_MS_HEX-000681_Met_Neg-20231008_MS_HEX-000681_Cortex_Met_Neg_017.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20231007_MS_HEX-000681_HALO_Pos-20231007_MS_HEX-000681_Cortex_HALO_Pos_017.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20231010_MS_HEX-000681_GM_Neg-20231010_MS_HEX-000681_Cortex_GM_Neg_017.mzML
SUBJECT_SAMPLE_FACTORS           	Cortex_19	HSA-000034482	genotype:WT | Sample source:brain	sex=Female; age=4.5; age_unit=month; region=Cortex; RAW_FILE_NAME(Raw Source Name.PITC)=20231013_MS_HEX-000681_PITC_Pos-20231013_MS_HEX-000681_Cortex_PITC_Pos_018.mzML; RAW_FILE_NAME(Raw Source Name.LP)=20231006_MS_HEX-000681_Lipid_Pos-20231006_MS_HEX-000681_Cortex_Lipid_Pos_018.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20231008_MS_HEX-000681_Lipid_Neg-20231008_MS_HEX-000681_Cortex_Lipid_Neg_018.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20231007_MS_HEX-000681_Met_Pos-20231007_MS_HEX-000681_Cortex_Met_Pos_018.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20231008_MS_HEX-000681_Met_Neg-20231008_MS_HEX-000681_Cortex_Met_Neg_018.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20231007_MS_HEX-000681_HALO_Pos-20231007_MS_HEX-000681_Cortex_HALO_Pos_018.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20231010_MS_HEX-000681_GM_Neg-20231010_MS_HEX-000681_Cortex_GM_Neg_018.mzML
SUBJECT_SAMPLE_FACTORS           	Cortex_02	HSA-000034465	genotype:HOM KO ATP13A2 | Sample source:brain	sex=Male; age=4.5; age_unit=month; region=Cortex; RAW_FILE_NAME(Raw Source Name.PITC)=20231013_MS_HEX-000681_PITC_Pos-20231013_MS_HEX-000681_Cortex_PITC_Pos_019.mzML; RAW_FILE_NAME(Raw Source Name.LP)=20231006_MS_HEX-000681_Lipid_Pos-20231006_MS_HEX-000681_Cortex_Lipid_Pos_019.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20231008_MS_HEX-000681_Lipid_Neg-20231008_MS_HEX-000681_Cortex_Lipid_Neg_019.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20231007_MS_HEX-000681_Met_Pos-20231007_MS_HEX-000681_Cortex_Met_Pos_019.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20231008_MS_HEX-000681_Met_Neg-20231008_MS_HEX-000681_Cortex_Met_Neg_019.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20231007_MS_HEX-000681_HALO_Pos-20231007_MS_HEX-000681_Cortex_HALO_Pos_019.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20231010_MS_HEX-000681_GM_Neg-20231010_MS_HEX-000681_Cortex_GM_Neg_019.mzML
SUBJECT_SAMPLE_FACTORS           	Cortex_05	HSA-000034468	genotype:HOM KO ATP13A2 | Sample source:brain	sex=Male; age=4.5; age_unit=month; region=Cortex; RAW_FILE_NAME(Raw Source Name.PITC)=20231013_MS_HEX-000681_PITC_Pos-20231013_MS_HEX-000681_Cortex_PITC_Pos_020.mzML; RAW_FILE_NAME(Raw Source Name.LP)=20231006_MS_HEX-000681_Lipid_Pos-20231006_MS_HEX-000681_Cortex_Lipid_Pos_020.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20231008_MS_HEX-000681_Lipid_Neg-20231008_MS_HEX-000681_Cortex_Lipid_Neg_020.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20231007_MS_HEX-000681_Met_Pos-20231007_MS_HEX-000681_Cortex_Met_Pos_020.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20231008_MS_HEX-000681_Met_Neg-20231008_MS_HEX-000681_Cortex_Met_Neg_020.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20231007_MS_HEX-000681_HALO_Pos-20231007_MS_HEX-000681_Cortex_HALO_Pos_020.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20231010_MS_HEX-000681_GM_Neg-20231010_MS_HEX-000681_Cortex_GM_Neg_020.mzML
SUBJECT_SAMPLE_FACTORS           	Cortex_10	HSA-000034473	genotype:WT | Sample source:brain	sex=Male; age=4.5; age_unit=month; region=Cortex; RAW_FILE_NAME(Raw Source Name.PITC)=20231013_MS_HEX-000681_PITC_Pos-20231013_MS_HEX-000681_Cortex_PITC_Pos_021.mzML; RAW_FILE_NAME(Raw Source Name.LP)=20231006_MS_HEX-000681_Lipid_Pos-20231006_MS_HEX-000681_Cortex_Lipid_Pos_021.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20231008_MS_HEX-000681_Lipid_Neg-20231008_MS_HEX-000681_Cortex_Lipid_Neg_021.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20231007_MS_HEX-000681_Met_Pos-20231007_MS_HEX-000681_Cortex_Met_Pos_021.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20231008_MS_HEX-000681_Met_Neg-20231008_MS_HEX-000681_Cortex_Met_Neg_021.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20231007_MS_HEX-000681_HALO_Pos-20231007_MS_HEX-000681_Cortex_HALO_Pos_021.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20231010_MS_HEX-000681_GM_Neg-20231010_MS_HEX-000681_Cortex_GM_Neg_021.mzML
SUBJECT_SAMPLE_FACTORS           	Cortex_06	HSA-000034469	genotype:HET KO ATP13A2 | Sample source:brain	sex=Male; age=4.5; age_unit=month; region=Cortex; RAW_FILE_NAME(Raw Source Name.PITC)=20231013_MS_HEX-000681_PITC_Pos-20231013_MS_HEX-000681_Cortex_PITC_Pos_022.mzML; RAW_FILE_NAME(Raw Source Name.LP)=20231006_MS_HEX-000681_Lipid_Pos-20231006_MS_HEX-000681_Cortex_Lipid_Pos_022.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20231008_MS_HEX-000681_Lipid_Neg-20231008_MS_HEX-000681_Cortex_Lipid_Neg_022.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20231007_MS_HEX-000681_Met_Pos-20231007_MS_HEX-000681_Cortex_Met_Pos_022.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20231008_MS_HEX-000681_Met_Neg-20231008_MS_HEX-000681_Cortex_Met_Neg_022.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20231007_MS_HEX-000681_HALO_Pos-20231007_MS_HEX-000681_Cortex_HALO_Pos_022.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20231010_MS_HEX-000681_GM_Neg-20231010_MS_HEX-000681_Cortex_GM_Neg_022.mzML
SUBJECT_SAMPLE_FACTORS           	Cortex_pool-3	HSA-000035024	genotype:NA | Sample source:brain	sex=NA; age=4.5; age_unit=month; region=Cortex; RAW_FILE_NAME(Raw Source Name.PITC)=20231013_MS_HEX-000681_PITC_Pos-20231013_MS_HEX-000681_Cortex_PITC_Pos_023.mzML; RAW_FILE_NAME(Raw Source Name.LP)=20231006_MS_HEX-000681_Lipid_Pos-20231006_MS_HEX-000681_Cortex_Lipid_Pos_023.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20231008_MS_HEX-000681_Lipid_Neg-20231008_MS_HEX-000681_Cortex_Lipid_Neg_023.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20231007_MS_HEX-000681_Met_Pos-20231007_MS_HEX-000681_Cortex_Met_Pos_023.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20231008_MS_HEX-000681_Met_Neg-20231008_MS_HEX-000681_Cortex_Met_Neg_023.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20231007_MS_HEX-000681_HALO_Pos-20231007_MS_HEX-000681_Cortex_HALO_Pos_023.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20231010_MS_HEX-000681_GM_Neg-20231010_MS_HEX-000681_Cortex_GM_Neg_023.mzML
SUBJECT_SAMPLE_FACTORS           	Hipp_pool-1	HSA-000034505	genotype:NA | Sample source:brain	sex=NA; age=4.5; age_unit=month; region=Hippocampus; RAW_FILE_NAME(Raw Source Name.PITC)=20231013_MS_HEX-000681_PITC_Pos-20231013_MS_HEX-000681_HC_PITC_Pos_001.mzML; RAW_FILE_NAME(Raw Source Name.LP)=20231006_MS_HEX-000681_Lipid_Pos-20231006_MS_HEX-000681_HC_Lipid_Pos_001.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20231008_MS_HEX-000681_Lipid_Neg-20231008_MS_HEX-000681_HC_Lipid_Neg_001.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20231007_MS_HEX-000681_Met_Pos-20231007_MS_HEX-000681_HC_Met_Pos_001.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20231008_MS_HEX-000681_Met_Neg-20231008_MS_HEX-000681_HC_Met_Neg_001.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20231007_MS_HEX-000681_HALO_Pos-20231007_MS_HEX-000681_HC_HALO_Pos_001.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20231010_MS_HEX-000681_GM_Neg-20231010_MS_HEX-000681_HC_GM_Neg_001.mzML
SUBJECT_SAMPLE_FACTORS           	Hipp_18	HSA-000034502	genotype:HET KO ATP13A2 | Sample source:brain	sex=Female; age=4.5; age_unit=month; region=Hippocampus; RAW_FILE_NAME(Raw Source Name.PITC)=20231013_MS_HEX-000681_PITC_Pos-20231013_MS_HEX-000681_HC_PITC_Pos_002.mzML; RAW_FILE_NAME(Raw Source Name.LP)=20231006_MS_HEX-000681_Lipid_Pos-20231006_MS_HEX-000681_HC_Lipid_Pos_002.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20231008_MS_HEX-000681_Lipid_Neg-20231008_MS_HEX-000681_HC_Lipid_Neg_002.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20231007_MS_HEX-000681_Met_Pos-20231007_MS_HEX-000681_HC_Met_Pos_002.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20231008_MS_HEX-000681_Met_Neg-20231008_MS_HEX-000681_HC_Met_Neg_002.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20231007_MS_HEX-000681_HALO_Pos-20231007_MS_HEX-000681_HC_HALO_Pos_002.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20231010_MS_HEX-000681_GM_Neg-20231010_MS_HEX-000681_HC_GM_Neg_002.mzML
SUBJECT_SAMPLE_FACTORS           	Hipp_06	HSA-000034490	genotype:HET KO ATP13A2 | Sample source:brain	sex=Male; age=4.5; age_unit=month; region=Hippocampus; RAW_FILE_NAME(Raw Source Name.PITC)=20231013_MS_HEX-000681_PITC_Pos-20231013_MS_HEX-000681_HC_PITC_Pos_003.mzML; RAW_FILE_NAME(Raw Source Name.LP)=20231006_MS_HEX-000681_Lipid_Pos-20231006_MS_HEX-000681_HC_Lipid_Pos_003.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20231008_MS_HEX-000681_Lipid_Neg-20231008_MS_HEX-000681_HC_Lipid_Neg_003.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20231007_MS_HEX-000681_Met_Pos-20231007_MS_HEX-000681_HC_Met_Pos_003.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20231008_MS_HEX-000681_Met_Neg-20231008_MS_HEX-000681_HC_Met_Neg_003.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20231007_MS_HEX-000681_HALO_Pos-20231007_MS_HEX-000681_HC_HALO_Pos_003.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20231010_MS_HEX-000681_GM_Neg-20231010_MS_HEX-000681_HC_GM_Neg_003.mzML
SUBJECT_SAMPLE_FACTORS           	Hipp_05	HSA-000034489	genotype:HOM KO ATP13A2 | Sample source:brain	sex=Male; age=4.5; age_unit=month; region=Hippocampus; RAW_FILE_NAME(Raw Source Name.PITC)=20231013_MS_HEX-000681_PITC_Pos-20231013_MS_HEX-000681_HC_PITC_Pos_004.mzML; RAW_FILE_NAME(Raw Source Name.LP)=20231006_MS_HEX-000681_Lipid_Pos-20231006_MS_HEX-000681_HC_Lipid_Pos_004.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20231008_MS_HEX-000681_Lipid_Neg-20231008_MS_HEX-000681_HC_Lipid_Neg_004.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20231007_MS_HEX-000681_Met_Pos-20231007_MS_HEX-000681_HC_Met_Pos_004.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20231008_MS_HEX-000681_Met_Neg-20231008_MS_HEX-000681_HC_Met_Neg_004.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20231007_MS_HEX-000681_HALO_Pos-20231007_MS_HEX-000681_HC_HALO_Pos_004.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20231010_MS_HEX-000681_GM_Neg-20231010_MS_HEX-000681_HC_GM_Neg_004.mzML
SUBJECT_SAMPLE_FACTORS           	Hipp_16	HSA-000034500	genotype:WT | Sample source:brain	sex=Female; age=4.5; age_unit=month; region=Hippocampus; RAW_FILE_NAME(Raw Source Name.PITC)=20231013_MS_HEX-000681_PITC_Pos-20231013_MS_HEX-000681_HC_PITC_Pos_005.mzML; RAW_FILE_NAME(Raw Source Name.LP)=20231006_MS_HEX-000681_Lipid_Pos-20231006_MS_HEX-000681_HC_Lipid_Pos_005.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20231008_MS_HEX-000681_Lipid_Neg-20231008_MS_HEX-000681_HC_Lipid_Neg_005.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20231007_MS_HEX-000681_Met_Pos-20231007_MS_HEX-000681_HC_Met_Pos_005.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20231008_MS_HEX-000681_Met_Neg-20231008_MS_HEX-000681_HC_Met_Neg_005.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20231007_MS_HEX-000681_HALO_Pos-20231007_MS_HEX-000681_HC_HALO_Pos_005.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20231010_MS_HEX-000681_GM_Neg-20231010_MS_HEX-000681_HC_GM_Neg_005.mzML
SUBJECT_SAMPLE_FACTORS           	Hipp_08	HSA-000034492	genotype:HOM KO ATP13A2 | Sample source:brain	sex=Female; age=4.5; age_unit=month; region=Hippocampus; RAW_FILE_NAME(Raw Source Name.PITC)=20231013_MS_HEX-000681_PITC_Pos-20231013_MS_HEX-000681_HC_PITC_Pos_006.mzML; RAW_FILE_NAME(Raw Source Name.LP)=20231006_MS_HEX-000681_Lipid_Pos-20231006_MS_HEX-000681_HC_Lipid_Pos_006.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20231008_MS_HEX-000681_Lipid_Neg-20231008_MS_HEX-000681_HC_Lipid_Neg_006.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20231007_MS_HEX-000681_Met_Pos-20231007_MS_HEX-000681_HC_Met_Pos_006.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20231008_MS_HEX-000681_Met_Neg-20231008_MS_HEX-000681_HC_Met_Neg_006.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20231007_MS_HEX-000681_HALO_Pos-20231007_MS_HEX-000681_HC_HALO_Pos_006.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20231010_MS_HEX-000681_GM_Neg-20231010_MS_HEX-000681_HC_GM_Neg_006.mzML
SUBJECT_SAMPLE_FACTORS           	Hipp_03	HSA-000034487	genotype:HET KO ATP13A2 | Sample source:brain	sex=Male; age=4.5; age_unit=month; region=Hippocampus; RAW_FILE_NAME(Raw Source Name.PITC)=20231013_MS_HEX-000681_PITC_Pos-20231013_MS_HEX-000681_HC_PITC_Pos_007.mzML; RAW_FILE_NAME(Raw Source Name.LP)=20231006_MS_HEX-000681_Lipid_Pos-20231006_MS_HEX-000681_HC_Lipid_Pos_007.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20231008_MS_HEX-000681_Lipid_Neg-20231008_MS_HEX-000681_HC_Lipid_Neg_007.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20231007_MS_HEX-000681_Met_Pos-20231007_MS_HEX-000681_HC_Met_Pos_007.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20231008_MS_HEX-000681_Met_Neg-20231008_MS_HEX-000681_HC_Met_Neg_007.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20231007_MS_HEX-000681_HALO_Pos-20231007_MS_HEX-000681_HC_HALO_Pos_007.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20231010_MS_HEX-000681_GM_Neg-20231010_MS_HEX-000681_HC_GM_Neg_007.mzML
SUBJECT_SAMPLE_FACTORS           	Hipp_01	HSA-000034485	genotype:WT | Sample source:brain	sex=Female; age=4.5; age_unit=month; region=Hippocampus; RAW_FILE_NAME(Raw Source Name.PITC)=20231013_MS_HEX-000681_PITC_Pos-20231013_MS_HEX-000681_HC_PITC_Pos_008.mzML; RAW_FILE_NAME(Raw Source Name.LP)=20231006_MS_HEX-000681_Lipid_Pos-20231006_MS_HEX-000681_HC_Lipid_Pos_008.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20231008_MS_HEX-000681_Lipid_Neg-20231008_MS_HEX-000681_HC_Lipid_Neg_008.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20231007_MS_HEX-000681_Met_Pos-20231007_MS_HEX-000681_HC_Met_Pos_008.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20231008_MS_HEX-000681_Met_Neg-20231008_MS_HEX-000681_HC_Met_Neg_008.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20231007_MS_HEX-000681_HALO_Pos-20231007_MS_HEX-000681_HC_HALO_Pos_008.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20231010_MS_HEX-000681_GM_Neg-20231010_MS_HEX-000681_HC_GM_Neg_008.mzML
SUBJECT_SAMPLE_FACTORS           	Hipp_20	HSA-000034504	genotype:HOM KO ATP13A2 | Sample source:brain	sex=Female; age=4.5; age_unit=month; region=Hippocampus; RAW_FILE_NAME(Raw Source Name.PITC)=20231013_MS_HEX-000681_PITC_Pos-20231013_MS_HEX-000681_HC_PITC_Pos_009.mzML; RAW_FILE_NAME(Raw Source Name.LP)=20231006_MS_HEX-000681_Lipid_Pos-20231006_MS_HEX-000681_HC_Lipid_Pos_009.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20231008_MS_HEX-000681_Lipid_Neg-20231008_MS_HEX-000681_HC_Lipid_Neg_009.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20231007_MS_HEX-000681_Met_Pos-20231007_MS_HEX-000681_HC_Met_Pos_009.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20231008_MS_HEX-000681_Met_Neg-20231008_MS_HEX-000681_HC_Met_Neg_009.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20231007_MS_HEX-000681_HALO_Pos-20231007_MS_HEX-000681_HC_HALO_Pos_009.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20231010_MS_HEX-000681_GM_Neg-20231010_MS_HEX-000681_HC_GM_Neg_009.mzML
SUBJECT_SAMPLE_FACTORS           	Hipp_13	HSA-000034497	genotype:WT | Sample source:brain	sex=Male; age=4.5; age_unit=month; region=Hippocampus; RAW_FILE_NAME(Raw Source Name.PITC)=20231013_MS_HEX-000681_PITC_Pos-20231013_MS_HEX-000681_HC_PITC_Pos_010.mzML; RAW_FILE_NAME(Raw Source Name.LP)=20231006_MS_HEX-000681_Lipid_Pos-20231006_MS_HEX-000681_HC_Lipid_Pos_010.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20231008_MS_HEX-000681_Lipid_Neg-20231008_MS_HEX-000681_HC_Lipid_Neg_010.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20231007_MS_HEX-000681_Met_Pos-20231007_MS_HEX-000681_HC_Met_Pos_010.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20231008_MS_HEX-000681_Met_Neg-20231008_MS_HEX-000681_HC_Met_Neg_010.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20231007_MS_HEX-000681_HALO_Pos-20231007_MS_HEX-000681_HC_HALO_Pos_010.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20231010_MS_HEX-000681_GM_Neg-20231010_MS_HEX-000681_HC_GM_Neg_010.mzML
SUBJECT_SAMPLE_FACTORS           	Hipp_pool-2	HSA-000035025	genotype:NA | Sample source:brain	sex=NA; age=4.5; age_unit=month; region=Hippocampus; RAW_FILE_NAME(Raw Source Name.PITC)=20231013_MS_HEX-000681_PITC_Pos-20231013_MS_HEX-000681_HC_PITC_Pos_011.mzML; RAW_FILE_NAME(Raw Source Name.LP)=20231006_MS_HEX-000681_Lipid_Pos-20231006_MS_HEX-000681_HC_Lipid_Pos_011.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20231008_MS_HEX-000681_Lipid_Neg-20231008_MS_HEX-000681_HC_Lipid_Neg_011.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20231007_MS_HEX-000681_Met_Pos-20231007_MS_HEX-000681_HC_Met_Pos_011.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20231008_MS_HEX-000681_Met_Neg-20231008_MS_HEX-000681_HC_Met_Neg_011.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20231007_MS_HEX-000681_HALO_Pos-20231007_MS_HEX-000681_HC_HALO_Pos_011.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20231010_MS_HEX-000681_GM_Neg-20231010_MS_HEX-000681_HC_GM_Neg_011.mzML
SUBJECT_SAMPLE_FACTORS           	Hipp_02	HSA-000034486	genotype:HOM KO ATP13A2 | Sample source:brain	sex=Male; age=4.5; age_unit=month; region=Hippocampus; RAW_FILE_NAME(Raw Source Name.PITC)=20231013_MS_HEX-000681_PITC_Pos-20231013_MS_HEX-000681_HC_PITC_Pos_012.mzML; RAW_FILE_NAME(Raw Source Name.LP)=20231006_MS_HEX-000681_Lipid_Pos-20231006_MS_HEX-000681_HC_Lipid_Pos_012.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20231008_MS_HEX-000681_Lipid_Neg-20231008_MS_HEX-000681_HC_Lipid_Neg_012.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20231007_MS_HEX-000681_Met_Pos-20231007_MS_HEX-000681_HC_Met_Pos_012.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20231008_MS_HEX-000681_Met_Neg-20231008_MS_HEX-000681_HC_Met_Neg_012.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20231007_MS_HEX-000681_HALO_Pos-20231007_MS_HEX-000681_HC_HALO_Pos_012.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20231010_MS_HEX-000681_GM_Neg-20231010_MS_HEX-000681_HC_GM_Neg_012.mzML
SUBJECT_SAMPLE_FACTORS           	Hipp_10	HSA-000034494	genotype:WT | Sample source:brain	sex=Male; age=4.5; age_unit=month; region=Hippocampus; RAW_FILE_NAME(Raw Source Name.PITC)=20231013_MS_HEX-000681_PITC_Pos-20231013_MS_HEX-000681_HC_PITC_Pos_013.mzML; RAW_FILE_NAME(Raw Source Name.LP)=20231006_MS_HEX-000681_Lipid_Pos-20231006_MS_HEX-000681_HC_Lipid_Pos_013.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20231008_MS_HEX-000681_Lipid_Neg-20231008_MS_HEX-000681_HC_Lipid_Neg_013.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20231007_MS_HEX-000681_Met_Pos-20231007_MS_HEX-000681_HC_Met_Pos_013.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20231008_MS_HEX-000681_Met_Neg-20231008_MS_HEX-000681_HC_Met_Neg_013.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20231007_MS_HEX-000681_HALO_Pos-20231007_MS_HEX-000681_HC_HALO_Pos_013.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20231010_MS_HEX-000681_GM_Neg-20231010_MS_HEX-000681_HC_GM_Neg_013.mzML
SUBJECT_SAMPLE_FACTORS           	Hipp_15	HSA-000034499	genotype:HET KO ATP13A2 | Sample source:brain	sex=Male; age=4.5; age_unit=month; region=Hippocampus; RAW_FILE_NAME(Raw Source Name.PITC)=20231013_MS_HEX-000681_PITC_Pos-20231013_MS_HEX-000681_HC_PITC_Pos_014.mzML; RAW_FILE_NAME(Raw Source Name.LP)=20231006_MS_HEX-000681_Lipid_Pos-20231006_MS_HEX-000681_HC_Lipid_Pos_014.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20231008_MS_HEX-000681_Lipid_Neg-20231008_MS_HEX-000681_HC_Lipid_Neg_014.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20231007_MS_HEX-000681_Met_Pos-20231007_MS_HEX-000681_HC_Met_Pos_014.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20231008_MS_HEX-000681_Met_Neg-20231008_MS_HEX-000681_HC_Met_Neg_014.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20231007_MS_HEX-000681_HALO_Pos-20231007_MS_HEX-000681_HC_HALO_Pos_014.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20231010_MS_HEX-000681_GM_Neg-20231010_MS_HEX-000681_HC_GM_Neg_014.mzML
SUBJECT_SAMPLE_FACTORS           	Hipp_14	HSA-000034498	genotype:HOM KO ATP13A2 | Sample source:brain	sex=Female; age=4.5; age_unit=month; region=Hippocampus; RAW_FILE_NAME(Raw Source Name.PITC)=20231013_MS_HEX-000681_PITC_Pos-20231013_MS_HEX-000681_HC_PITC_Pos_015.mzML; RAW_FILE_NAME(Raw Source Name.LP)=20231006_MS_HEX-000681_Lipid_Pos-20231006_MS_HEX-000681_HC_Lipid_Pos_015.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20231008_MS_HEX-000681_Lipid_Neg-20231008_MS_HEX-000681_HC_Lipid_Neg_015.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20231007_MS_HEX-000681_Met_Pos-20231007_MS_HEX-000681_HC_Met_Pos_015.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20231008_MS_HEX-000681_Met_Neg-20231008_MS_HEX-000681_HC_Met_Neg_015.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20231007_MS_HEX-000681_HALO_Pos-20231007_MS_HEX-000681_HC_HALO_Pos_015.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20231010_MS_HEX-000681_GM_Neg-20231010_MS_HEX-000681_HC_GM_Neg_015.mzML
SUBJECT_SAMPLE_FACTORS           	Hipp_11	HSA-000034495	genotype:HOM KO ATP13A2 | Sample source:brain	sex=Female; age=4.5; age_unit=month; region=Hippocampus; RAW_FILE_NAME(Raw Source Name.PITC)=20231013_MS_HEX-000681_PITC_Pos-20231013_MS_HEX-000681_HC_PITC_Pos_016.mzML; RAW_FILE_NAME(Raw Source Name.LP)=20231006_MS_HEX-000681_Lipid_Pos-20231006_MS_HEX-000681_HC_Lipid_Pos_016.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20231008_MS_HEX-000681_Lipid_Neg-20231008_MS_HEX-000681_HC_Lipid_Neg_016.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20231007_MS_HEX-000681_Met_Pos-20231007_MS_HEX-000681_HC_Met_Pos_016.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20231008_MS_HEX-000681_Met_Neg-20231008_MS_HEX-000681_HC_Met_Neg_016.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20231007_MS_HEX-000681_HALO_Pos-20231007_MS_HEX-000681_HC_HALO_Pos_016.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20231010_MS_HEX-000681_GM_Neg-20231010_MS_HEX-000681_HC_GM_Neg_016.mzML
SUBJECT_SAMPLE_FACTORS           	Hipp_19	HSA-000034503	genotype:WT | Sample source:brain	sex=Female; age=4.5; age_unit=month; region=Hippocampus; RAW_FILE_NAME(Raw Source Name.PITC)=20231013_MS_HEX-000681_PITC_Pos-20231013_MS_HEX-000681_HC_PITC_Pos_017.mzML; RAW_FILE_NAME(Raw Source Name.LP)=20231006_MS_HEX-000681_Lipid_Pos-20231006_MS_HEX-000681_HC_Lipid_Pos_017.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20231008_MS_HEX-000681_Lipid_Neg-20231008_MS_HEX-000681_HC_Lipid_Neg_017.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20231007_MS_HEX-000681_Met_Pos-20231007_MS_HEX-000681_HC_Met_Pos_017.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20231008_MS_HEX-000681_Met_Neg-20231008_MS_HEX-000681_HC_Met_Neg_017.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20231007_MS_HEX-000681_HALO_Pos-20231007_MS_HEX-000681_HC_HALO_Pos_017.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20231010_MS_HEX-000681_GM_Neg-20231010_MS_HEX-000681_HC_GM_Neg_017.mzML
SUBJECT_SAMPLE_FACTORS           	Hipp_09	HSA-000034493	genotype:HET KO ATP13A2 | Sample source:brain	sex=Male; age=4.5; age_unit=month; region=Hippocampus; RAW_FILE_NAME(Raw Source Name.PITC)=20231013_MS_HEX-000681_PITC_Pos-20231013_MS_HEX-000681_HC_PITC_Pos_018.mzML; RAW_FILE_NAME(Raw Source Name.LP)=20231006_MS_HEX-000681_Lipid_Pos-20231006_MS_HEX-000681_HC_Lipid_Pos_018.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20231008_MS_HEX-000681_Lipid_Neg-20231008_MS_HEX-000681_HC_Lipid_Neg_018.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20231007_MS_HEX-000681_Met_Pos-20231007_MS_HEX-000681_HC_Met_Pos_018.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20231008_MS_HEX-000681_Met_Neg-20231008_MS_HEX-000681_HC_Met_Neg_018.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20231007_MS_HEX-000681_HALO_Pos-20231007_MS_HEX-000681_HC_HALO_Pos_018.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20231010_MS_HEX-000681_GM_Neg-20231010_MS_HEX-000681_HC_GM_Neg_018.mzML
SUBJECT_SAMPLE_FACTORS           	Hipp_04	HSA-000034488	genotype:WT | Sample source:brain	sex=Female; age=4.5; age_unit=month; region=Hippocampus; RAW_FILE_NAME(Raw Source Name.PITC)=20231013_MS_HEX-000681_PITC_Pos-20231013_MS_HEX-000681_HC_PITC_Pos_019.mzML; RAW_FILE_NAME(Raw Source Name.LP)=20231006_MS_HEX-000681_Lipid_Pos-20231006_MS_HEX-000681_HC_Lipid_Pos_019.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20231008_MS_HEX-000681_Lipid_Neg-20231008_MS_HEX-000681_HC_Lipid_Neg_019.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20231007_MS_HEX-000681_Met_Pos-20231007_MS_HEX-000681_HC_Met_Pos_019.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20231008_MS_HEX-000681_Met_Neg-20231008_MS_HEX-000681_HC_Met_Neg_019.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20231007_MS_HEX-000681_HALO_Pos-20231007_MS_HEX-000681_HC_HALO_Pos_019.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20231010_MS_HEX-000681_GM_Neg-20231010_MS_HEX-000681_HC_GM_Neg_019.mzML
SUBJECT_SAMPLE_FACTORS           	Hipp_17	HSA-000034501	genotype:HOM KO ATP13A2 | Sample source:brain	sex=Female; age=4.5; age_unit=month; region=Hippocampus; RAW_FILE_NAME(Raw Source Name.PITC)=20231013_MS_HEX-000681_PITC_Pos-20231013_MS_HEX-000681_HC_PITC_Pos_020.mzML; RAW_FILE_NAME(Raw Source Name.LP)=20231006_MS_HEX-000681_Lipid_Pos-20231006_MS_HEX-000681_HC_Lipid_Pos_020.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20231008_MS_HEX-000681_Lipid_Neg-20231008_MS_HEX-000681_HC_Lipid_Neg_020.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20231007_MS_HEX-000681_Met_Pos-20231007_MS_HEX-000681_HC_Met_Pos_020.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20231008_MS_HEX-000681_Met_Neg-20231008_MS_HEX-000681_HC_Met_Neg_020.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20231007_MS_HEX-000681_HALO_Pos-20231007_MS_HEX-000681_HC_HALO_Pos_020.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20231010_MS_HEX-000681_GM_Neg-20231010_MS_HEX-000681_HC_GM_Neg_020.mzML
SUBJECT_SAMPLE_FACTORS           	Hipp_12	HSA-000034496	genotype:HET KO ATP13A2 | Sample source:brain	sex=Male; age=4.5; age_unit=month; region=Hippocampus; RAW_FILE_NAME(Raw Source Name.PITC)=20231013_MS_HEX-000681_PITC_Pos-20231013_MS_HEX-000681_HC_PITC_Pos_021.mzML; RAW_FILE_NAME(Raw Source Name.LP)=20231006_MS_HEX-000681_Lipid_Pos-20231006_MS_HEX-000681_HC_Lipid_Pos_021.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20231008_MS_HEX-000681_Lipid_Neg-20231008_MS_HEX-000681_HC_Lipid_Neg_021.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20231007_MS_HEX-000681_Met_Pos-20231007_MS_HEX-000681_HC_Met_Pos_021.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20231008_MS_HEX-000681_Met_Neg-20231008_MS_HEX-000681_HC_Met_Neg_021.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20231007_MS_HEX-000681_HALO_Pos-20231007_MS_HEX-000681_HC_HALO_Pos_021.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20231010_MS_HEX-000681_GM_Neg-20231010_MS_HEX-000681_HC_GM_Neg_021.mzML
SUBJECT_SAMPLE_FACTORS           	Hipp_07	HSA-000034491	genotype:WT | Sample source:brain	sex=Male; age=4.5; age_unit=month; region=Hippocampus; RAW_FILE_NAME(Raw Source Name.PITC)=20231013_MS_HEX-000681_PITC_Pos-20231013_MS_HEX-000681_HC_PITC_Pos_022.mzML; RAW_FILE_NAME(Raw Source Name.LP)=20231006_MS_HEX-000681_Lipid_Pos-20231006_MS_HEX-000681_HC_Lipid_Pos_022.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20231008_MS_HEX-000681_Lipid_Neg-20231008_MS_HEX-000681_HC_Lipid_Neg_022.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20231007_MS_HEX-000681_Met_Pos-20231007_MS_HEX-000681_HC_Met_Pos_022.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20231008_MS_HEX-000681_Met_Neg-20231008_MS_HEX-000681_HC_Met_Neg_022.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20231007_MS_HEX-000681_HALO_Pos-20231007_MS_HEX-000681_HC_HALO_Pos_022.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20231010_MS_HEX-000681_GM_Neg-20231010_MS_HEX-000681_HC_GM_Neg_022.mzML
SUBJECT_SAMPLE_FACTORS           	Hipp_pool-3	HSA-000035026	genotype:NA | Sample source:brain	sex=NA; age=4.5; age_unit=month; region=Hippocampus; RAW_FILE_NAME(Raw Source Name.PITC)=20231013_MS_HEX-000681_PITC_Pos-20231013_MS_HEX-000681_HC_PITC_Pos_023.mzML; RAW_FILE_NAME(Raw Source Name.LP)=20231006_MS_HEX-000681_Lipid_Pos-20231006_MS_HEX-000681_HC_Lipid_Pos_023.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20231008_MS_HEX-000681_Lipid_Neg-20231008_MS_HEX-000681_HC_Lipid_Neg_023.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20231007_MS_HEX-000681_Met_Pos-20231007_MS_HEX-000681_HC_Met_Pos_023.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20231008_MS_HEX-000681_Met_Neg-20231008_MS_HEX-000681_HC_Met_Neg_023.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20231007_MS_HEX-000681_HALO_Pos-20231007_MS_HEX-000681_HC_HALO_Pos_023.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20231010_MS_HEX-000681_GM_Neg-20231010_MS_HEX-000681_HC_GM_Neg_023.mzML
#COLLECTION
CO:COLLECTION_SUMMARY            	Heterozygous Atp13a2<tm1Pjsch> animals of genotype
CO:COLLECTION_SUMMARY            	B6N.129S6(Cg)-Atp13a2tm1Pjsch/J were obtained from The Jackson Laboratory (JAX
CO:COLLECTION_SUMMARY            	strain 021914)17 and were crossed to generate homozygous Atp13a2 KO (Atp13a2
CO:COLLECTION_SUMMARY            	–/–) animals. For both the 5-month and 15-month-old cohort, female and male
CO:COLLECTION_SUMMARY            	mice were used in comparable percentages (see table below). In case of the
CO:COLLECTION_SUMMARY            	15-month-old Atp13a2 KO cohort, one of the animals died prior to study
CO:COLLECTION_SUMMARY            	conclusion and was excluded. Animals were maintained and all procedures
CO:COLLECTION_SUMMARY            	performed in adherence to ethical regulations and protocols approved by the
CO:COLLECTION_SUMMARY            	Denali Therapeutics Inc. Institutional Animal Care and Use Committee (IACUC).
CO:COLLECTION_SUMMARY            	Mice were housed under a 12-h light/12-h dark cycle and had access to water and
CO:COLLECTION_SUMMARY            	standard rodent diet ad libitum. Running wheels were provided for enrichment to
CO:COLLECTION_SUMMARY            	the cohort that was aged to 15 months.Animals were deeply anesthetized via
CO:COLLECTION_SUMMARY            	intraperitoneal injection of 2.5% Avertin and transcardially perfused with
CO:COLLECTION_SUMMARY            	ice-cold PBS using a peristaltic pump (Gilson Inc. Minipuls Evolution). The
CO:COLLECTION_SUMMARY            	brain was then removed and one hemisphere sub-dissected into the anterior cortex
CO:COLLECTION_SUMMARY            	and hippocampus, while the other was retained without sub-dissection. Tissue
CO:COLLECTION_SUMMARY            	samples were individually weighed, flash frozen on dry ice and stored at -80°C
CO:COLLECTION_SUMMARY            	for subsequent analysis.
CO:SAMPLE_TYPE                   	Brain
CO:STORAGE_CONDITIONS            	-80℃
CO:COLLECTION_VIALS              	Lobind 1.5 mL Eppendorf tubes
CO:STORAGE_VIALS                 	Lobind 1.5 mL Eppendorf tubes
#TREATMENT
TR:TREATMENT_SUMMARY             	No treatment
#SAMPLEPREP
SP:SAMPLEPREP_SUMMARY            	For tissue samples, 20 (± 3) mg of anterior cortex or 15 (± 2) mg of
SP:SAMPLEPREP_SUMMARY            	hippocampus from the left hemisphere of each individual animal was dissected,
SP:SAMPLEPREP_SUMMARY            	weighed and flash frozen during tissue collection. Lipids and metabolites were
SP:SAMPLEPREP_SUMMARY            	extracted from the frozen samples using 400 mL of HPLC-grade methanol (Fisher
SP:SAMPLEPREP_SUMMARY            	Chemical; # A452-4) containing stable-isotope internal standards and homogenized
SP:SAMPLEPREP_SUMMARY            	with a 3 mm tungsten carbide bead for 45 s at 25 Hz on TissueLyzer II (QIAGEN,
SP:SAMPLEPREP_SUMMARY            	#85300). The methanol fraction was isolated via centrifugation (20 min at 4°C,
SP:SAMPLEPREP_SUMMARY            	14,000 x g, transferred to a 96-well sample collection plate (Waters;
SP:SAMPLEPREP_SUMMARY            	#186005837) and incubated for 1 h, at -20°C for protein precipitation,
SP:SAMPLEPREP_SUMMARY            	followed by an additional 20 min centrifugation (4,000 x g at 4°C). The
SP:SAMPLEPREP_SUMMARY            	supernatant was transferred to glass vial plates (Analytical systems, #27350)
SP:SAMPLEPREP_SUMMARY            	for LCMS analysis.
SP:PROCESSING_STORAGE_CONDITIONS 	On ice
SP:EXTRACT_STORAGE               	-20℃
#CHROMATOGRAPHY
CH:CHROMATOGRAPHY_TYPE           	Reversed phase
CH:INSTRUMENT_NAME               	Agilent 1290 Infinity II
CH:COLUMN_NAME                   	Waters ACQUITY UPLC BEH C18 (100 x 2.1mm,1.7um)
CH:SOLVENT_A                     	60% acetonitrile/40% water; 10 mM ammonium acetate; 0.1% acetic acid
CH:SOLVENT_B                     	90% isopropyl alcohol/10% acetonitrile; 10 mM ammonium acetate; 0.1% acetic acid
CH:FLOW_GRADIENT                 	0.0-8.0 min from 45% B to 99% B, 8.0-9.0 min at 99% B, 9.0-9.1 min to 45% B, and
CH:FLOW_GRADIENT                 	9.1-10.0 min at 45% B.
CH:FLOW_RATE                     	0.25 mL/min
CH:COLUMN_TEMPERATURE            	55
#ANALYSIS
AN:ANALYSIS_TYPE                 	MS
#MS
MS:INSTRUMENT_NAME               	ABI Sciex 6500+ QTrap
MS:INSTRUMENT_TYPE               	Triple quadrupole
MS:MS_TYPE                       	ESI
MS:ION_MODE                      	NEGATIVE
MS:MS_COMMENTS                   	curtain gas at 30 psi; collision gas set at medium; ion spray voltage at 4,500
MS:MS_COMMENTS                   	V; temperature at 600°C; ion source Gas 1 at 55 psi; ion source Gas 2 at 60
MS:MS_COMMENTS                   	psi.
#MS_METABOLITE_DATA
MS_METABOLITE_DATA:UNITS	normalized peak area
MS_METABOLITE_DATA_START
Samples	HSA-000038800	HSA-000038799	HSA-000038794	HSA-000038788	HSA-000038797	HSA-000038790	HSA-000038798	HSA-000038795	HSA-000039091	HSA-000038796	HSA-000038791	HSA-000038787	HSA-000038792	HSA-000038793	HSA-000038789	HSA-000039092	HSA-000038814	HSA-000038813	HSA-000038811	HSA-000038804	HSA-000038805	HSA-000038803	HSA-000038802	HSA-000038807	HSA-000039093	HSA-000038809	HSA-000038812	HSA-000038806	HSA-000038801	HSA-000038810	HSA-000038808	HSA-000039094	HSA-000034484	HSA-000034472	HSA-000034470	HSA-000034479	HSA-000034467	HSA-000034483	HSA-000034481	HSA-000034478	HSA-000034471	HSA-000034466	HSA-000034477	HSA-000035023	HSA-000034480	HSA-000034474	HSA-000034475	HSA-000034464	HSA-000034476	HSA-000034482	HSA-000034465	HSA-000034468	HSA-000034473	HSA-000034469	HSA-000035024	HSA-000034505	HSA-000034502	HSA-000034490	HSA-000034489	HSA-000034500	HSA-000034492	HSA-000034487	HSA-000034485	HSA-000034504	HSA-000034497	HSA-000035025	HSA-000034486	HSA-000034494	HSA-000034499	HSA-000034498	HSA-000034495	HSA-000034503	HSA-000034493	HSA-000034488	HSA-000034501	HSA-000034496	HSA-000034491	HSA-000035026
Factors	genotype:WT | Sample source:brain	genotype:HOM KO ATP13A2 | Sample source:brain	genotype:HOM KO ATP13A2 | Sample source:brain	genotype:WT | Sample source:brain	genotype:HOM KO ATP13A2 | Sample source:brain	genotype:HOM KO ATP13A2 | Sample source:brain	genotype:WT | Sample source:brain	genotype:NA | Sample source:brain	genotype:HOM KO ATP13A2 | Sample source:brain	genotype:WT | Sample source:brain	genotype:WT | Sample source:brain	genotype:HOM KO ATP13A2 | Sample source:brain	genotype:WT | Sample source:brain	genotype:WT | Sample source:brain	genotype:NA | Sample source:brain	genotype:NA | Sample source:brain	genotype:WT | Sample source:brain	genotype:WT | Sample source:brain	genotype:HOM KO ATP13A2 | Sample source:brain	genotype:WT | Sample source:brain	genotype:WT | Sample source:brain	genotype:HOM KO ATP13A2 | Sample source:brain	genotype:WT | Sample source:brain	genotype:NA | Sample source:brain	genotype:WT | Sample source:brain	genotype:HOM KO ATP13A2 | Sample source:brain	genotype:HOM KO ATP13A2 | Sample source:brain	genotype:WT | Sample source:brain	genotype:HOM KO ATP13A2 | Sample source:brain	genotype:HOM KO ATP13A2 | Sample source:brain	genotype:NA | Sample source:brain	genotype:NA | Sample source:brain	genotype:NA | Sample source:brain	genotype:HET KO ATP13A2 | Sample source:brain	genotype:WT | Sample source:brain	genotype:WT | Sample source:brain	genotype:WT | Sample source:brain	genotype:HOM KO ATP13A2 | Sample source:brain	genotype:HET KO ATP13A2 | Sample source:brain	genotype:HET KO ATP13A2 | Sample source:brain	genotype:HOM KO ATP13A2 | Sample source:brain	genotype:HET KO ATP13A2 | Sample source:brain	genotype:HOM KO ATP13A2 | Sample source:brain	genotype:NA | Sample source:brain	genotype:HOM KO ATP13A2 | Sample source:brain	genotype:HOM KO ATP13A2 | Sample source:brain	genotype:HET KO ATP13A2 | Sample source:brain	genotype:WT | Sample source:brain	genotype:WT | Sample source:brain	genotype:WT | Sample source:brain	genotype:HOM KO ATP13A2 | Sample source:brain	genotype:HOM KO ATP13A2 | Sample source:brain	genotype:WT | Sample source:brain	genotype:HET KO ATP13A2 | Sample source:brain	genotype:NA | Sample source:brain	genotype:NA | Sample source:brain	genotype:HET KO ATP13A2 | Sample source:brain	genotype:HET KO ATP13A2 | Sample source:brain	genotype:HOM KO ATP13A2 | Sample source:brain	genotype:WT | Sample source:brain	genotype:HOM KO ATP13A2 | Sample source:brain	genotype:HET KO ATP13A2 | Sample source:brain	genotype:WT | Sample source:brain	genotype:HOM KO ATP13A2 | Sample source:brain	genotype:WT | Sample source:brain	genotype:NA | Sample source:brain	genotype:HOM KO ATP13A2 | Sample source:brain	genotype:WT | Sample source:brain	genotype:HET KO ATP13A2 | Sample source:brain	genotype:HOM KO ATP13A2 | Sample source:brain	genotype:HOM KO ATP13A2 | Sample source:brain	genotype:WT | Sample source:brain	genotype:HET KO ATP13A2 | Sample source:brain	genotype:WT | Sample source:brain	genotype:HOM KO ATP13A2 | Sample source:brain	genotype:HET KO ATP13A2 | Sample source:brain	genotype:WT | Sample source:brain	genotype:NA | Sample source:brain
GM1(d18:1/18:0(d3))	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.
GM1(d34:1)	0.161	0.177	0.098	0.139	0.185	0.173	0.159	0.139	0.26	0.192	0.149	0.119	0.15	0.141	0.158	0.175	0.095	0.113	0.13	0.121	0.095	0.09	0.051	0.113	0.098	0.097	0.207	0.089	0.09	0.127	0.12	0.087	0.678	0.605	0.397	0.494	0.523	0.437	0.558	0.793	0.514	0.634	0.436	0.517	0.552	0.545	0.565	0.603	0.998	0.702	0.473	0.655	0.629	0.486	0.57	0.437	0.327	0.389	0.302	0.256	0.29	0.264	0.337	0.258	0.386	0.419	0.364	0.335	0.17	0.391	0.298	0.495	0.541	0.413	0.322	0.347	0.321	0.353
GM1(d36:1)	0.959	0.813	1.189	0.752	0.767	0.677	1.221	1.516	1.076	0.987	1.001	0.925	0.87	1.334	0.827	1.028	1.139	0.944	0.748	0.71	0.823	1.031	1.034	0.86	0.937	0.875	1.318	0.821	0.994	0.751	0.684	0.811	7.246	9.021	7.553	7.743	5.653	5.273	5.701	9.201	4.729	7.484	7.035	6.425	3.724	6.231	5.595	5.218	4.812	5.177	7.493	5.686	6.079	7.744	6.473	9.499	7.229	6.26	6.695	6.519	5.953	6.858	7.188	6.403	6.692	10.039	8.334	6.212	5.354	7.521	6.089	8.507	8.354	7.082	7.06	6.658	6.041	8.508
GM1(d38:1)	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	0.259	0.502	0.606	0.397	0.211	0.118	0.138	0.299	0.111	0.322	0.33	0.262	0.122	0.223	0.157	0.141	0.203	0.135	0.431	0.127	0.187	0.432	0.217	0.794	0.473	0.35	0.582	0.38	0.299	0.316	0.375	0.325	0.501	0.802	0.466	0.349	0.462	0.419	0.352	0.494	0.33	0.267	0.393	0.318	0.384	0.737
GM1(d40:1)	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.
GM2(d18:1/16:0(d9))	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.
GM2(d34:1)	0.205	0.184	0.08	0.141	0.183	0.153	0.114	0.106	0.201	0.173	0.102	0.141	0.13	0.104	0.13	0.22	0.079	0.09	0.129	0.098	0.085	0.05	0.028	0.08	0.092	0.068	0.184	0.076	0.076	0.124	0.115	0.078	0.296	0.239	0.199	0.208	0.229	0.236	0.248	0.455	0.221	0.359	0.247	0.244	0.541	0.29	0.306	0.317	0.528	0.478	0.201	0.476	0.365	0.17	0.23	0.193	0.125	0.157	0.132	0.106	0.121	0.16	0.177	0.113	0.177	0.189	0.143	0.11	0.119	0.156	0.148	0.164	0.205	0.212	0.141	0.121	0.116	0.149
GM2(d36:1)	1.076	0.992	1.744	1.444	1.04	1.358	1.571	1.492	1.201	1.57	1.084	0.977	1.477	1.609	1.011	1.037	1.351	1.105	0.816	1.172	0.98	1.012	0.957	1.184	0.939	1.082	2.106	1.213	1.64	1.058	1.024	0.832	2.816	1.938	1.543	1.856	1.832	3.061	2.248	3.146	2.256	2.329	2.521	2.704	2.416	2.361	2.162	1.865	1.96	2.253	2.471	3.391	2.316	1.793	2.54	2.607	1.764	1.843	2.145	1.377	2.261	1.921	2.03	2.227	1.632	2.5	2.289	1.792	1.066	2.294	2.439	2.353	2.258	2.176	2.178	1.897	1.795	2.439
GM2(d38:1)	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	0.253	0.115	0.129	0.185	0.081	0.123	0.092	0.165	0.096	0.154	0.24	0.168	0.117	0.084	0.208	0.115	0.165	0.102	0.131	0.132	0.122	0.112	0.238
GM2(d40:1)	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.
GM3(d18:1/18:0(d5))	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.
GM3(d34:1)	5.798	4.649	2.92	4.97	3.586	3.835	2.626	0.97	6.71	5.123	3.132	6.812	1.667	1.374	3.045	5.691	1.595	1.445	2.466	1.849	1.79	1.441	0.585	1.793	2.285	1.764	5.63	1.908	0.47	3.459	3.599	2.287	3.897	2.77	2.364	2.055	4.781	4.634	3.209	5.477	3.457	3.53	2.953	3.837	6.306	4.974	5.662	5.235	9.554	5.133	1.931	6.564	5.078	1.335	3.596	2.351	2.303	2.617	1.471	1.562	2.566	2.278	2.535	2.417	2.122	2.646	2.669	2.506	1.624	2.525	1.782	2.7	2.779	3.027	3.811	2.478	1.748	2.211
GM3(d36:1)	31.277	32.075	37.559	36.015	32	31.007	52.912	27.667	36.336	40.518	35.806	32.69	31.234	31.949	29.813	31.958	29.638	41.016	35.957	36.629	40.169	25.421	18.171	43.504	28.19	35.216	47.726	41.489	17.838	46.722	44.055	25.979	23.827	21.178	15.708	19.013	26.041	29.086	25.027	35.327	20.742	22.264	20.561	27.036	28.006	30.595	24.653	21.802	30.508	28.583	17.449	35.675	27.517	17.381	24.294	31.606	30.437	27.615	22.085	23.549	26.724	31.628	31.587	28.691	27.229	27.918	28.916	25.36	23.707	36.086	29.082	39.677	33.472	31.808	31.755	30.755	27.182	27.726
GM3(d38:1)	1.222	0.616	1.715	0.863	0.48	0.534	1.2	0.48	1.055	0.868	0.766	0.9	0.568	0.695	0.566	1.083	1.048	0.66	0.525	0.576	0.527	1.12	1.101	0.644	0.738	0.905	1.036	1.03	0.512	0.68	0.703	0.687	2.804	3.878	4.142	2.64	2.655	2.555	2.34	3.812	2.86	3.013	2.875	2.492	1.732	3.454	2.644	2.19	2.129	1.953	3.438	2.651	2.495	3.065	2.42	6.759	5.706	6.386	3.701	3.984	5.769	3.538	5.854	4.871	5.466	7.312	6.65	6.621	3.745	4.718	4.584	5.053	6.654	6.898	8.979	4.573	4.342	6.403
GM3(d40:1)	0.227	0.11	0.357	0.161	0.072	0.085	0.191	0.081	0.322	0.129	0.134	0.214	0.104	0.118	0.108	0.227	0.248	0.1	0.07	0.092	0.07	0.294	0.273	0.096	0.172	0.246	0.241	0.226	0.108	0.116	0.123	0.133	0.88	1.057	1.269	0.611	0.67	0.835	0.534	0.979	0.664	0.907	0.689	0.647	0.427	0.712	0.852	0.661	0.706	0.534	0.702	0.758	0.729	0.452	0.625	2.177	1.559	2.187	0.656	0.728	2.018	0.626	1.906	1.084	1.791	2.471	2.78	2.332	0.718	0.755	1.035	0.875	2.103	2.322	2.701	1	0.814	1.958
MS_METABOLITE_DATA_END
#METABOLITES
METABOLITES_START
metabolite_name	Expected RT	MS1_mz	MS2_mz
GM3(d18:1/18:0(d5))	4.8	1184.8	290.1
GM3(d34:1)	4.3	1151.7	290.1
GM3(d36:1)	4.8	1179.8	290.1
GM3(d38:1)	5.2	1207.8	290.1
GM3(d40:1)	5.6	1235.8	290.1
GM2(d18:1/16:0(d9))	4.4	1363.8	290.1
GM2(d34:1)	4.4	1354.8	290.1
GM2(d36:1)	4.8	1382.8	290.1
GM2(d38:1)	5.2	1410.7	290.1
GM2(d40:1)	5.6	1438.7	290.1
GM1(d18:1/18:0(d3))	4.3	1519.9	290.1
GM1(d34:1)	4.3	1516.9	290.1
GM1(d36:1)	4.7	1544.9	290.1
GM1(d38:1)	5.2	1572.9	290.1
GM1(d40:1)	5.6	1600.9	290.1
METABOLITES_END
#END