#METABOLOMICS WORKBENCH Jung_DNLI_20250707_104749 DATATRACK_ID:6141 STUDY_ID:ST004059 ANALYSIS_ID:AN006717 PROJECT_ID:PR002548
VERSION             	1
CREATED_ON             	July 22, 2025, 11:13 am
#PROJECT
PR:PROJECT_TITLE                 	Lysosomal polyamine storage upon ATP13A2 loss impairs β-glucocerebrosidase via
PR:PROJECT_TITLE                 	altered lysosomal pH and electrostatic hydrolase-lipid interactions
PR:PROJECT_TYPE                  	Preclinical Mouse and cellular studies
PR:PROJECT_SUMMARY               	ATP13A2 is an endolysosomal polyamine transporter mutated in several
PR:PROJECT_SUMMARY               	neurodegenerative conditions involving lysosomal defects, including
PR:PROJECT_SUMMARY               	Parkinson’s disease (PD). While polyamines are polybasic and polycationic
PR:PROJECT_SUMMARY               	molecules that play pleiotropic cellular roles, their specific impact on
PR:PROJECT_SUMMARY               	lysosomal health is unknown. Here, we demonstrate lysosomal polyamine
PR:PROJECT_SUMMARY               	accumulation in ATP13A2 knockout (KO) cell lines. Primary polyamine storage
PR:PROJECT_SUMMARY               	caused secondary storage of lysosomal anionic phospholipid
PR:PROJECT_SUMMARY               	bis(monoacylglycero)phosphate (BMP) and age-dependent increase in the
PR:PROJECT_SUMMARY               	β-glucocerebrosidase (GCase) substrate, glucosylsphingosine, in Atp13a2 KO
PR:PROJECT_SUMMARY               	brains. Polyamine accumulation inhibited lysosomal GCase activity in cells and
PR:PROJECT_SUMMARY               	this was reversed by lysosome reacidification or BMP supplementation. A
PR:PROJECT_SUMMARY               	liposome-based GCase assay utilizing physiological substrates demonstrated
PR:PROJECT_SUMMARY               	dose-dependent inhibition of BMP-stimulated GCase activity by polyamines, in
PR:PROJECT_SUMMARY               	part via a pH-independent, electrostatics-based mechanism. Therefore, excess
PR:PROJECT_SUMMARY               	polyamine compromises lysosomes by disrupting pH and electrostatic interactions
PR:PROJECT_SUMMARY               	between GCase and BMP enabling efficient substrate hydrolysis, potentially
PR:PROJECT_SUMMARY               	clarifying their pathogenic mechanisms, and suggesting convergence on
PR:PROJECT_SUMMARY               	PD-relevant pathways.
PR:INSTITUTE                     	Denali Therapeutics
PR:LAST_NAME                     	Suh
PR:FIRST_NAME                    	Jung
PR:ADDRESS                       	161 Oyster Point Blvd, South San Francisco, California, 94080, USA
PR:EMAIL                         	suh@dnli.com
PR:PHONE                         	+1 06507973837
#STUDY
ST:STUDY_TITLE                   	Targeted Lipid and Metabolite Profiling in Brains of ATP13A2 Knockout Mice
ST:STUDY_SUMMARY                 	Comprehensive targeted profiling of lipids and metabolites was conducted in
ST:STUDY_SUMMARY                 	brain tissues from ATP13A2 knockout mice at 4.5 and 15 months of age to assess
ST:STUDY_SUMMARY                 	ATP13A2 deletion and its association with lysosomal dysfunction.
ST:INSTITUTE                     	Denali Therapeutics
ST:LAST_NAME                     	Suh
ST:FIRST_NAME                    	Jung
ST:ADDRESS                       	161 Oyster Point Blvd, South San Francisco, California, 94080, USA
ST:EMAIL                         	suh@dnli.com
ST:PHONE                         	+1 06507973837
#SUBJECT
SU:SUBJECT_TYPE                  	Mammal
SU:SUBJECT_SPECIES               	Mus musculus
SU:TAXONOMY_ID                   	10090
#SUBJECT_SAMPLE_FACTORS:         	SUBJECT(optional)[tab]SAMPLE[tab]FACTORS(NAME:VALUE pairs separated by |)[tab]Raw file names and additional sample data
SUBJECT_SAMPLE_FACTORS           	Pool_Cortex_001	HSA-000038800	genotype:WT | Sample source:brain	sex=NA; age=15; age_unit=month; region=Cortex; RAW_FILE_NAME(Raw Source Name.PITC)=20240607_MS_HEX-000817_PITC_Pos-20240607_MS_HEX-000817_Cortex_PITC_Pos_001.mzML; RAW_FILE_NAME(Raw Source Name.LP)=20240521_MS_HEX-000817_Lipid_Pos_001.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20240524_MS_HEX-000817_Lipid_Neg_001.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20240523_MS_HEX-000817_Met_Pos_001.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20240524_MS_HEX-000817_Met_Neg_001.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20240522_MS_HEX-000817_HALO_Pos_001.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20240528_MS_HEX-000817_GM_Neg_001.mzML
SUBJECT_SAMPLE_FACTORS           	Cortex_13	HSA-000038799	genotype:HOM KO ATP13A2 | Sample source:brain	sex=Male; age=15; age_unit=month; region=Cortex; RAW_FILE_NAME(Raw Source Name.PITC)=20240607_MS_HEX-000817_PITC_Pos-20240607_MS_HEX-000817_Cortex_PITC_Pos_002.mzML; RAW_FILE_NAME(Raw Source Name.LP)=20240521_MS_HEX-000817_Lipid_Pos_002.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20240524_MS_HEX-000817_Lipid_Neg_002.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20240523_MS_HEX-000817_Met_Pos_002.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20240524_MS_HEX-000817_Met_Neg_002.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20240522_MS_HEX-000817_HALO_Pos_002.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20240528_MS_HEX-000817_GM_Neg_002.mzML
SUBJECT_SAMPLE_FACTORS           	Cortex_08	HSA-000038794	genotype:HOM KO ATP13A2 | Sample source:brain	sex=Female; age=15; age_unit=month; region=Cortex; RAW_FILE_NAME(Raw Source Name.PITC)=20240607_MS_HEX-000817_PITC_Pos-20240607_MS_HEX-000817_Cortex_PITC_Pos_003.mzML; RAW_FILE_NAME(Raw Source Name.LP)=20240521_MS_HEX-000817_Lipid_Pos_003.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20240524_MS_HEX-000817_Lipid_Neg_003.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20240523_MS_HEX-000817_Met_Pos_003.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20240524_MS_HEX-000817_Met_Neg_003.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20240522_MS_HEX-000817_HALO_Pos_003.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20240528_MS_HEX-000817_GM_Neg_003.mzML
SUBJECT_SAMPLE_FACTORS           	Cortex_02	HSA-000038788	genotype:WT | Sample source:brain	sex=Male; age=15; age_unit=month; region=Cortex; RAW_FILE_NAME(Raw Source Name.PITC)=20240607_MS_HEX-000817_PITC_Pos-20240607_MS_HEX-000817_Cortex_PITC_Pos_004.mzML; RAW_FILE_NAME(Raw Source Name.LP)=20240521_MS_HEX-000817_Lipid_Pos_004.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20240524_MS_HEX-000817_Lipid_Neg_004.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20240523_MS_HEX-000817_Met_Pos_004.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20240524_MS_HEX-000817_Met_Neg_004.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20240522_MS_HEX-000817_HALO_Pos_004.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20240528_MS_HEX-000817_GM_Neg_004.mzML
SUBJECT_SAMPLE_FACTORS           	Cortex_11	HSA-000038797	genotype:HOM KO ATP13A2 | Sample source:brain	sex=Male; age=15; age_unit=month; region=Cortex; RAW_FILE_NAME(Raw Source Name.PITC)=20240607_MS_HEX-000817_PITC_Pos-20240607_MS_HEX-000817_Cortex_PITC_Pos_005.mzML; RAW_FILE_NAME(Raw Source Name.LP)=20240521_MS_HEX-000817_Lipid_Pos_005.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20240524_MS_HEX-000817_Lipid_Neg_005.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20240523_MS_HEX-000817_Met_Pos_005.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20240524_MS_HEX-000817_Met_Neg_005.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20240522_MS_HEX-000817_HALO_Pos_005.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20240528_MS_HEX-000817_GM_Neg_005.mzML
SUBJECT_SAMPLE_FACTORS           	Cortex_04	HSA-000038790	genotype:HOM KO ATP13A2 | Sample source:brain	sex=Male; age=15; age_unit=month; region=Cortex; RAW_FILE_NAME(Raw Source Name.PITC)=20240607_MS_HEX-000817_PITC_Pos-20240607_MS_HEX-000817_Cortex_PITC_Pos_006.mzML; RAW_FILE_NAME(Raw Source Name.LP)=20240521_MS_HEX-000817_Lipid_Pos_006.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20240524_MS_HEX-000817_Lipid_Neg_006.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20240523_MS_HEX-000817_Met_Pos_006.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20240524_MS_HEX-000817_Met_Neg_006.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20240522_MS_HEX-000817_HALO_Pos_006.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20240528_MS_HEX-000817_GM_Neg_006.mzML
SUBJECT_SAMPLE_FACTORS           	Cortex_12	HSA-000038798	genotype:WT | Sample source:brain	sex=Female; age=15; age_unit=month; region=Cortex; RAW_FILE_NAME(Raw Source Name.PITC)=20240607_MS_HEX-000817_PITC_Pos-20240607_MS_HEX-000817_Cortex_PITC_Pos_007.mzML; RAW_FILE_NAME(Raw Source Name.LP)=20240521_MS_HEX-000817_Lipid_Pos_007.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20240524_MS_HEX-000817_Lipid_Neg_007.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20240523_MS_HEX-000817_Met_Pos_007.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20240524_MS_HEX-000817_Met_Neg_007.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20240522_MS_HEX-000817_HALO_Pos_007.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20240528_MS_HEX-000817_GM_Neg_007.mzML
SUBJECT_SAMPLE_FACTORS           	Cortex_09	HSA-000038795	genotype:NA | Sample source:brain	sex=Male; age=15; age_unit=month; region=Cortex; RAW_FILE_NAME(Raw Source Name.PITC)=20240607_MS_HEX-000817_PITC_Pos-20240607_MS_HEX-000817_Cortex_PITC_Pos_008.mzML; RAW_FILE_NAME(Raw Source Name.LP)=20240521_MS_HEX-000817_Lipid_Pos_008.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20240524_MS_HEX-000817_Lipid_Neg_008.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20240523_MS_HEX-000817_Met_Pos_008.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20240524_MS_HEX-000817_Met_Neg_008.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20240522_MS_HEX-000817_HALO_Pos_008.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20240528_MS_HEX-000817_GM_Neg_008.mzML
SUBJECT_SAMPLE_FACTORS           	Pool_Cortex_002	HSA-000039091	genotype:HOM KO ATP13A2 | Sample source:brain	sex=NA; age=15; age_unit=month; region=Cortex; RAW_FILE_NAME(Raw Source Name.PITC)=20240607_MS_HEX-000817_PITC_Pos-20240607_MS_HEX-000817_Cortex_PITC_Pos_009.mzML; RAW_FILE_NAME(Raw Source Name.LP)=20240521_MS_HEX-000817_Lipid_Pos_009.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20240524_MS_HEX-000817_Lipid_Neg_009.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20240523_MS_HEX-000817_Met_Pos_009.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20240524_MS_HEX-000817_Met_Neg_009.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20240522_MS_HEX-000817_HALO_Pos_009.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20240528_MS_HEX-000817_GM_Neg_009.mzML
SUBJECT_SAMPLE_FACTORS           	Cortex_10	HSA-000038796	genotype:WT | Sample source:brain	sex=Female; age=15; age_unit=month; region=Cortex; RAW_FILE_NAME(Raw Source Name.PITC)=20240607_MS_HEX-000817_PITC_Pos-20240607_MS_HEX-000817_Cortex_PITC_Pos_010.mzML; RAW_FILE_NAME(Raw Source Name.LP)=20240521_MS_HEX-000817_Lipid_Pos_010.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20240524_MS_HEX-000817_Lipid_Neg_010.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20240523_MS_HEX-000817_Met_Pos_010.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20240524_MS_HEX-000817_Met_Neg_010.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20240522_MS_HEX-000817_HALO_Pos_010.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20240528_MS_HEX-000817_GM_Neg_010.mzML
SUBJECT_SAMPLE_FACTORS           	Cortex_05	HSA-000038791	genotype:WT | Sample source:brain	sex=Female; age=15; age_unit=month; region=Cortex; RAW_FILE_NAME(Raw Source Name.PITC)=20240607_MS_HEX-000817_PITC_Pos-20240607_MS_HEX-000817_Cortex_PITC_Pos_011.mzML; RAW_FILE_NAME(Raw Source Name.LP)=20240521_MS_HEX-000817_Lipid_Pos_011.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20240524_MS_HEX-000817_Lipid_Neg_011.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20240523_MS_HEX-000817_Met_Pos_011.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20240524_MS_HEX-000817_Met_Neg_011.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20240522_MS_HEX-000817_HALO_Pos_011.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20240528_MS_HEX-000817_GM_Neg_011.mzML
SUBJECT_SAMPLE_FACTORS           	Cortex_01	HSA-000038787	genotype:HOM KO ATP13A2 | Sample source:brain	sex=Female; age=15; age_unit=month; region=Cortex; RAW_FILE_NAME(Raw Source Name.PITC)=20240607_MS_HEX-000817_PITC_Pos-20240607_MS_HEX-000817_Cortex_PITC_Pos_012.mzML; RAW_FILE_NAME(Raw Source Name.LP)=20240521_MS_HEX-000817_Lipid_Pos_012.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20240524_MS_HEX-000817_Lipid_Neg_012.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20240523_MS_HEX-000817_Met_Pos_012.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20240524_MS_HEX-000817_Met_Neg_012.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20240522_MS_HEX-000817_HALO_Pos_012.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20240528_MS_HEX-000817_GM_Neg_012.mzML
SUBJECT_SAMPLE_FACTORS           	Cortex_06	HSA-000038792	genotype:WT | Sample source:brain	sex=Male; age=15; age_unit=month; region=Cortex; RAW_FILE_NAME(Raw Source Name.PITC)=20240607_MS_HEX-000817_PITC_Pos-20240607_MS_HEX-000817_Cortex_PITC_Pos_013.mzML; RAW_FILE_NAME(Raw Source Name.LP)=20240521_MS_HEX-000817_Lipid_Pos_013.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20240524_MS_HEX-000817_Lipid_Neg_013.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20240523_MS_HEX-000817_Met_Pos_013.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20240524_MS_HEX-000817_Met_Neg_013.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20240522_MS_HEX-000817_HALO_Pos_013.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20240528_MS_HEX-000817_GM_Neg_013.mzML
SUBJECT_SAMPLE_FACTORS           	Cortex_07	HSA-000038793	genotype:WT | Sample source:brain	sex=Male; age=15; age_unit=month; region=Cortex; RAW_FILE_NAME(Raw Source Name.PITC)=20240607_MS_HEX-000817_PITC_Pos-20240607_MS_HEX-000817_Cortex_PITC_Pos_014.mzML; RAW_FILE_NAME(Raw Source Name.LP)=20240521_MS_HEX-000817_Lipid_Pos_014.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20240524_MS_HEX-000817_Lipid_Neg_014.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20240523_MS_HEX-000817_Met_Pos_014.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20240524_MS_HEX-000817_Met_Neg_014.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20240522_MS_HEX-000817_HALO_Pos_014.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20240528_MS_HEX-000817_GM_Neg_014.mzML
SUBJECT_SAMPLE_FACTORS           	Cortex_03	HSA-000038789	genotype:NA | Sample source:brain	sex=Female; age=15; age_unit=month; region=Cortex; RAW_FILE_NAME(Raw Source Name.PITC)=20240607_MS_HEX-000817_PITC_Pos-20240607_MS_HEX-000817_Cortex_PITC_Pos_015.mzML; RAW_FILE_NAME(Raw Source Name.LP)=20240521_MS_HEX-000817_Lipid_Pos_015.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20240524_MS_HEX-000817_Lipid_Neg_015.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20240523_MS_HEX-000817_Met_Pos_015.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20240524_MS_HEX-000817_Met_Neg_015.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20240522_MS_HEX-000817_HALO_Pos_015.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20240528_MS_HEX-000817_GM_Neg_015.mzML
SUBJECT_SAMPLE_FACTORS           	Pool_Cortex_003	HSA-000039092	genotype:NA | Sample source:brain	sex=NA; age=15; age_unit=month; region=Cortex; RAW_FILE_NAME(Raw Source Name.PITC)=20240607_MS_HEX-000817_PITC_Pos-20240607_MS_HEX-000817_Cortex_PITC_Pos_016.mzML; RAW_FILE_NAME(Raw Source Name.LP)=20240521_MS_HEX-000817_Lipid_Pos_016.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20240524_MS_HEX-000817_Lipid_Neg_016.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20240523_MS_HEX-000817_Met_Pos_016.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20240524_MS_HEX-000817_Met_Neg_016.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20240522_MS_HEX-000817_HALO_Pos_016.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20240528_MS_HEX-000817_GM_Neg_016.mzML
SUBJECT_SAMPLE_FACTORS           	Pool_Hippo_001	HSA-000038814	genotype:WT | Sample source:brain	sex=NA; age=15; age_unit=month; region=Hippocampus; RAW_FILE_NAME(Raw Source Name.PITC)=20240607_MS_HEX-000817_PITC_Pos-20240607_MS_HEX-000817_HippC_PITC_Pos_002; RAW_FILE_NAME(Raw Source Name.LP)=20240521_MS_HEX-000817_Lipid_Pos_017.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20240524_MS_HEX-000817_Lipid_Neg_017.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20240523_MS_HEX-000817_Met_Pos_017.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20240524_MS_HEX-000817_Met_Neg_017.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20240522_MS_HEX-000817_HALO_Pos_017.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20240528_MS_HEX-000817_GM_Neg_017.mzML
SUBJECT_SAMPLE_FACTORS           	Hipp_13	HSA-000038813	genotype:WT | Sample source:brain	sex=Male; age=15; age_unit=month; region=Hippocampus; RAW_FILE_NAME(Raw Source Name.PITC)=20240607_MS_HEX-000817_PITC_Pos-20240607_MS_HEX-000817_HippC_PITC_Pos_003; RAW_FILE_NAME(Raw Source Name.LP)=20240521_MS_HEX-000817_Lipid_Pos_018.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20240524_MS_HEX-000817_Lipid_Neg_018.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20240523_MS_HEX-000817_Met_Pos_018.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20240524_MS_HEX-000817_Met_Neg_018.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20240522_MS_HEX-000817_HALO_Pos_018.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20240528_MS_HEX-000817_GM_Neg_018.mzML
SUBJECT_SAMPLE_FACTORS           	Hipp_11	HSA-000038811	genotype:HOM KO ATP13A2 | Sample source:brain	sex=Male; age=15; age_unit=month; region=Hippocampus; RAW_FILE_NAME(Raw Source Name.PITC)=20240607_MS_HEX-000817_PITC_Pos-20240607_MS_HEX-000817_HippC_PITC_Pos_004; RAW_FILE_NAME(Raw Source Name.LP)=20240521_MS_HEX-000817_Lipid_Pos_019.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20240524_MS_HEX-000817_Lipid_Neg_019.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20240523_MS_HEX-000817_Met_Pos_019.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20240524_MS_HEX-000817_Met_Neg_019.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20240522_MS_HEX-000817_HALO_Pos_019.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20240528_MS_HEX-000817_GM_Neg_019.mzML
SUBJECT_SAMPLE_FACTORS           	Hipp_04	HSA-000038804	genotype:WT | Sample source:brain	sex=Male; age=15; age_unit=month; region=Hippocampus; RAW_FILE_NAME(Raw Source Name.PITC)=20240607_MS_HEX-000817_PITC_Pos-20240607_MS_HEX-000817_HippC_PITC_Pos_005; RAW_FILE_NAME(Raw Source Name.LP)=20240521_MS_HEX-000817_Lipid_Pos_020.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20240524_MS_HEX-000817_Lipid_Neg_020.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20240523_MS_HEX-000817_Met_Pos_020.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20240524_MS_HEX-000817_Met_Neg_020.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20240522_MS_HEX-000817_HALO_Pos_020.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20240528_MS_HEX-000817_GM_Neg_020.mzML
SUBJECT_SAMPLE_FACTORS           	Hipp_05	HSA-000038805	genotype:WT | Sample source:brain	sex=Female; age=15; age_unit=month; region=Hippocampus; RAW_FILE_NAME(Raw Source Name.PITC)=20240607_MS_HEX-000817_PITC_Pos-20240607_MS_HEX-000817_HippC_PITC_Pos_006; RAW_FILE_NAME(Raw Source Name.LP)=20240521_MS_HEX-000817_Lipid_Pos_021.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20240524_MS_HEX-000817_Lipid_Neg_021.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20240523_MS_HEX-000817_Met_Pos_021.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20240524_MS_HEX-000817_Met_Neg_021.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20240522_MS_HEX-000817_HALO_Pos_021.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20240528_MS_HEX-000817_GM_Neg_021.mzML
SUBJECT_SAMPLE_FACTORS           	Hipp_03	HSA-000038803	genotype:HOM KO ATP13A2 | Sample source:brain	sex=Female; age=15; age_unit=month; region=Hippocampus; RAW_FILE_NAME(Raw Source Name.PITC)=20240607_MS_HEX-000817_PITC_Pos-20240607_MS_HEX-000817_HippC_PITC_Pos_007; RAW_FILE_NAME(Raw Source Name.LP)=20240521_MS_HEX-000817_Lipid_Pos_022.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20240524_MS_HEX-000817_Lipid_Neg_022.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20240523_MS_HEX-000817_Met_Pos_022.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20240524_MS_HEX-000817_Met_Neg_022.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20240522_MS_HEX-000817_HALO_Pos_022.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20240528_MS_HEX-000817_GM_Neg_022.mzML
SUBJECT_SAMPLE_FACTORS           	Hipp_02	HSA-000038802	genotype:WT | Sample source:brain	sex=Male; age=15; age_unit=month; region=Hippocampus; RAW_FILE_NAME(Raw Source Name.PITC)=20240607_MS_HEX-000817_PITC_Pos-20240607_MS_HEX-000817_HippC_PITC_Pos_008; RAW_FILE_NAME(Raw Source Name.LP)=20240521_MS_HEX-000817_Lipid_Pos_023.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20240524_MS_HEX-000817_Lipid_Neg_023.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20240523_MS_HEX-000817_Met_Pos_023.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20240524_MS_HEX-000817_Met_Neg_023.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20240522_MS_HEX-000817_HALO_Pos_023.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20240528_MS_HEX-000817_GM_Neg_023.mzML
SUBJECT_SAMPLE_FACTORS           	Hipp_07	HSA-000038807	genotype:NA | Sample source:brain	sex=Male; age=15; age_unit=month; region=Hippocampus; RAW_FILE_NAME(Raw Source Name.PITC)=20240607_MS_HEX-000817_PITC_Pos-20240607_MS_HEX-000817_HippC_PITC_Pos_009; RAW_FILE_NAME(Raw Source Name.LP)=20240521_MS_HEX-000817_Lipid_Pos_024.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20240524_MS_HEX-000817_Lipid_Neg_024.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20240523_MS_HEX-000817_Met_Pos_024.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20240524_MS_HEX-000817_Met_Neg_024.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20240522_MS_HEX-000817_HALO_Pos_024.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20240528_MS_HEX-000817_GM_Neg_024.mzML
SUBJECT_SAMPLE_FACTORS           	Pool_Hippo_002	HSA-000039093	genotype:WT | Sample source:brain	sex=NA; age=15; age_unit=month; region=Hippocampus; RAW_FILE_NAME(Raw Source Name.PITC)=20240607_MS_HEX-000817_PITC_Pos-20240607_MS_HEX-000817_HippC_PITC_Pos_010; RAW_FILE_NAME(Raw Source Name.LP)=20240521_MS_HEX-000817_Lipid_Pos_025.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20240524_MS_HEX-000817_Lipid_Neg_025.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20240523_MS_HEX-000817_Met_Pos_025.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20240524_MS_HEX-000817_Met_Neg_025.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20240522_MS_HEX-000817_HALO_Pos_025.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20240528_MS_HEX-000817_GM_Neg_025.mzML
SUBJECT_SAMPLE_FACTORS           	Hipp_09	HSA-000038809	genotype:HOM KO ATP13A2 | Sample source:brain	sex=Male; age=15; age_unit=month; region=Hippocampus; RAW_FILE_NAME(Raw Source Name.PITC)=20240607_MS_HEX-000817_PITC_Pos-20240607_MS_HEX-000817_HippC_PITC_Pos_011; RAW_FILE_NAME(Raw Source Name.LP)=20240521_MS_HEX-000817_Lipid_Pos_026.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20240524_MS_HEX-000817_Lipid_Neg_026.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20240523_MS_HEX-000817_Met_Pos_026.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20240524_MS_HEX-000817_Met_Neg_026.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20240522_MS_HEX-000817_HALO_Pos_026.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20240528_MS_HEX-000817_GM_Neg_026.mzML
SUBJECT_SAMPLE_FACTORS           	Hipp_12	HSA-000038812	genotype:HOM KO ATP13A2 | Sample source:brain	sex=Female; age=15; age_unit=month; region=Hippocampus; RAW_FILE_NAME(Raw Source Name.PITC)=20240607_MS_HEX-000817_PITC_Pos-20240607_MS_HEX-000817_HippC_PITC_Pos_012; RAW_FILE_NAME(Raw Source Name.LP)=20240521_MS_HEX-000817_Lipid_Pos_027.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20240524_MS_HEX-000817_Lipid_Neg_027.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20240523_MS_HEX-000817_Met_Pos_027.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20240524_MS_HEX-000817_Met_Neg_027.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20240522_MS_HEX-000817_HALO_Pos_027.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20240528_MS_HEX-000817_GM_Neg_027.mzML
SUBJECT_SAMPLE_FACTORS           	Hipp_06	HSA-000038806	genotype:WT | Sample source:brain	sex=Male; age=15; age_unit=month; region=Hippocampus; RAW_FILE_NAME(Raw Source Name.PITC)=20240607_MS_HEX-000817_PITC_Pos-20240607_MS_HEX-000817_HippC_PITC_Pos_013; RAW_FILE_NAME(Raw Source Name.LP)=20240521_MS_HEX-000817_Lipid_Pos_028.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20240524_MS_HEX-000817_Lipid_Neg_028.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20240523_MS_HEX-000817_Met_Pos_028.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20240524_MS_HEX-000817_Met_Neg_028.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20240522_MS_HEX-000817_HALO_Pos_028.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20240528_MS_HEX-000817_GM_Neg_028.mzML
SUBJECT_SAMPLE_FACTORS           	Hipp_01	HSA-000038801	genotype:HOM KO ATP13A2 | Sample source:brain	sex=Female; age=15; age_unit=month; region=Hippocampus; RAW_FILE_NAME(Raw Source Name.PITC)=20240607_MS_HEX-000817_PITC_Pos-20240607_MS_HEX-000817_HippC_PITC_Pos_014; RAW_FILE_NAME(Raw Source Name.LP)=20240521_MS_HEX-000817_Lipid_Pos_029.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20240524_MS_HEX-000817_Lipid_Neg_029.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20240523_MS_HEX-000817_Met_Pos_029.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20240524_MS_HEX-000817_Met_Neg_029.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20240522_MS_HEX-000817_HALO_Pos_029.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20240528_MS_HEX-000817_GM_Neg_029.mzML
SUBJECT_SAMPLE_FACTORS           	Hipp_10	HSA-000038810	genotype:HOM KO ATP13A2 | Sample source:brain	sex=Female; age=15; age_unit=month; region=Hippocampus; RAW_FILE_NAME(Raw Source Name.PITC)=20240607_MS_HEX-000817_PITC_Pos-20240607_MS_HEX-000817_HippC_PITC_Pos_015; RAW_FILE_NAME(Raw Source Name.LP)=20240521_MS_HEX-000817_Lipid_Pos_030.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20240524_MS_HEX-000817_Lipid_Neg_030.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20240523_MS_HEX-000817_Met_Pos_030.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20240524_MS_HEX-000817_Met_Neg_030.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20240522_MS_HEX-000817_HALO_Pos_030.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20240528_MS_HEX-000817_GM_Neg_030.mzML
SUBJECT_SAMPLE_FACTORS           	Hipp_08	HSA-000038808	genotype:NA | Sample source:brain	sex=Female; age=15; age_unit=month; region=Hippocampus; RAW_FILE_NAME(Raw Source Name.PITC)=20240607_MS_HEX-000817_PITC_Pos-20240607_MS_HEX-000817_HippC_PITC_Pos_016; RAW_FILE_NAME(Raw Source Name.LP)=20240521_MS_HEX-000817_Lipid_Pos_031.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20240524_MS_HEX-000817_Lipid_Neg_031.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20240523_MS_HEX-000817_Met_Pos_031.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20240524_MS_HEX-000817_Met_Neg_031.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20240522_MS_HEX-000817_HALO_Pos_031.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20240528_MS_HEX-000817_GM_Neg_031.mzML
SUBJECT_SAMPLE_FACTORS           	Pool_Hippo_003	HSA-000039094	genotype:NA | Sample source:brain	sex=NA; age=15; age_unit=month; region=Hippocampus; RAW_FILE_NAME(Raw Source Name.PITC)=20240607_MS_HEX-000817_PITC_Pos-20240607_MS_HEX-000817_HippC_PITC_Pos_017; RAW_FILE_NAME(Raw Source Name.LP)=20240521_MS_HEX-000817_Lipid_Pos_032.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20240524_MS_HEX-000817_Lipid_Neg_032.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20240523_MS_HEX-000817_Met_Pos_032.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20240524_MS_HEX-000817_Met_Neg_032.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20240522_MS_HEX-000817_HALO_Pos_032.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20240528_MS_HEX-000817_GM_Neg_032.mzML
SUBJECT_SAMPLE_FACTORS           	Cortex_pool-1	HSA-000034484	genotype:NA | Sample source:brain	sex=NA; age=4.5; age_unit=month; region=Cortex; RAW_FILE_NAME(Raw Source Name.PITC)=20231013_MS_HEX-000681_PITC_Pos-20231013_MS_HEX-000681_Cortex_PITC_Pos_001.mzML; RAW_FILE_NAME(Raw Source Name.LP)=20231006_MS_HEX-000681_Lipid_Pos-20231006_MS_HEX-000681_Cortex_Lipid_Pos_001.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20231008_MS_HEX-000681_Lipid_Neg-20231008_MS_HEX-000681_Cortex_Lipid_Neg_001.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20231007_MS_HEX-000681_Met_Pos-20231007_MS_HEX-000681_Cortex_Met_Pos_001.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20231008_MS_HEX-000681_Met_Neg-20231008_MS_HEX-000681_Cortex_Met_Neg_001.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20231007_MS_HEX-000681_HALO_Pos-20231007_MS_HEX-000681_Cortex_HALO_Pos_001.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20231010_MS_HEX-000681_GM_Neg-20231010_MS_HEX-000681_Cortex_GM_Neg_001.mzML
SUBJECT_SAMPLE_FACTORS           	Cortex_09	HSA-000034472	genotype:HET KO ATP13A2 | Sample source:brain	sex=Male; age=4.5; age_unit=month; region=Cortex; RAW_FILE_NAME(Raw Source Name.PITC)=20231013_MS_HEX-000681_PITC_Pos-20231013_MS_HEX-000681_Cortex_PITC_Pos_002.mzML; RAW_FILE_NAME(Raw Source Name.LP)=20231006_MS_HEX-000681_Lipid_Pos-20231006_MS_HEX-000681_Cortex_Lipid_Pos_002.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20231008_MS_HEX-000681_Lipid_Neg-20231008_MS_HEX-000681_Cortex_Lipid_Neg_002.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20231007_MS_HEX-000681_Met_Pos-20231007_MS_HEX-000681_Cortex_Met_Pos_002.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20231008_MS_HEX-000681_Met_Neg-20231008_MS_HEX-000681_Cortex_Met_Neg_002.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20231007_MS_HEX-000681_HALO_Pos-20231007_MS_HEX-000681_Cortex_HALO_Pos_002.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20231010_MS_HEX-000681_GM_Neg-20231010_MS_HEX-000681_Cortex_GM_Neg_002.mzML
SUBJECT_SAMPLE_FACTORS           	Cortex_07	HSA-000034470	genotype:WT | Sample source:brain	sex=Male; age=4.5; age_unit=month; region=Cortex; RAW_FILE_NAME(Raw Source Name.PITC)=20231013_MS_HEX-000681_PITC_Pos-20231013_MS_HEX-000681_Cortex_PITC_Pos_003.mzML; RAW_FILE_NAME(Raw Source Name.LP)=20231006_MS_HEX-000681_Lipid_Pos-20231006_MS_HEX-000681_Cortex_Lipid_Pos_003.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20231008_MS_HEX-000681_Lipid_Neg-20231008_MS_HEX-000681_Cortex_Lipid_Neg_003.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20231007_MS_HEX-000681_Met_Pos-20231007_MS_HEX-000681_Cortex_Met_Pos_003.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20231008_MS_HEX-000681_Met_Neg-20231008_MS_HEX-000681_Cortex_Met_Neg_003.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20231007_MS_HEX-000681_HALO_Pos-20231007_MS_HEX-000681_Cortex_HALO_Pos_003.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20231010_MS_HEX-000681_GM_Neg-20231010_MS_HEX-000681_Cortex_GM_Neg_003.mzML
SUBJECT_SAMPLE_FACTORS           	Cortex_16	HSA-000034479	genotype:WT | Sample source:brain	sex=Female; age=4.5; age_unit=month; region=Cortex; RAW_FILE_NAME(Raw Source Name.PITC)=20231013_MS_HEX-000681_PITC_Pos-20231013_MS_HEX-000681_Cortex_PITC_Pos_004.mzML; RAW_FILE_NAME(Raw Source Name.LP)=20231006_MS_HEX-000681_Lipid_Pos-20231006_MS_HEX-000681_Cortex_Lipid_Pos_004.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20231008_MS_HEX-000681_Lipid_Neg-20231008_MS_HEX-000681_Cortex_Lipid_Neg_004.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20231007_MS_HEX-000681_Met_Pos-20231007_MS_HEX-000681_Cortex_Met_Pos_004.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20231008_MS_HEX-000681_Met_Neg-20231008_MS_HEX-000681_Cortex_Met_Neg_004.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20231007_MS_HEX-000681_HALO_Pos-20231007_MS_HEX-000681_Cortex_HALO_Pos_004.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20231010_MS_HEX-000681_GM_Neg-20231010_MS_HEX-000681_Cortex_GM_Neg_004.mzML
SUBJECT_SAMPLE_FACTORS           	Cortex_04	HSA-000034467	genotype:WT | Sample source:brain	sex=Female; age=4.5; age_unit=month; region=Cortex; RAW_FILE_NAME(Raw Source Name.PITC)=20231013_MS_HEX-000681_PITC_Pos-20231013_MS_HEX-000681_Cortex_PITC_Pos_005.mzML; RAW_FILE_NAME(Raw Source Name.LP)=20231006_MS_HEX-000681_Lipid_Pos-20231006_MS_HEX-000681_Cortex_Lipid_Pos_005.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20231008_MS_HEX-000681_Lipid_Neg-20231008_MS_HEX-000681_Cortex_Lipid_Neg_005.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20231007_MS_HEX-000681_Met_Pos-20231007_MS_HEX-000681_Cortex_Met_Pos_005.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20231008_MS_HEX-000681_Met_Neg-20231008_MS_HEX-000681_Cortex_Met_Neg_005.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20231007_MS_HEX-000681_HALO_Pos-20231007_MS_HEX-000681_Cortex_HALO_Pos_005.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20231010_MS_HEX-000681_GM_Neg-20231010_MS_HEX-000681_Cortex_GM_Neg_005.mzML
SUBJECT_SAMPLE_FACTORS           	Cortex_20	HSA-000034483	genotype:HOM KO ATP13A2 | Sample source:brain	sex=Female; age=4.5; age_unit=month; region=Cortex; RAW_FILE_NAME(Raw Source Name.PITC)=20231013_MS_HEX-000681_PITC_Pos-20231013_MS_HEX-000681_Cortex_PITC_Pos_006.mzML; RAW_FILE_NAME(Raw Source Name.LP)=20231006_MS_HEX-000681_Lipid_Pos-20231006_MS_HEX-000681_Cortex_Lipid_Pos_006.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20231008_MS_HEX-000681_Lipid_Neg-20231008_MS_HEX-000681_Cortex_Lipid_Neg_006.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20231007_MS_HEX-000681_Met_Pos-20231007_MS_HEX-000681_Cortex_Met_Pos_006.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20231008_MS_HEX-000681_Met_Neg-20231008_MS_HEX-000681_Cortex_Met_Neg_006.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20231007_MS_HEX-000681_HALO_Pos-20231007_MS_HEX-000681_Cortex_HALO_Pos_006.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20231010_MS_HEX-000681_GM_Neg-20231010_MS_HEX-000681_Cortex_GM_Neg_006.mzML
SUBJECT_SAMPLE_FACTORS           	Cortex_18	HSA-000034481	genotype:HET KO ATP13A2 | Sample source:brain	sex=Female; age=4.5; age_unit=month; region=Cortex; RAW_FILE_NAME(Raw Source Name.PITC)=20231013_MS_HEX-000681_PITC_Pos-20231013_MS_HEX-000681_Cortex_PITC_Pos_007.mzML; RAW_FILE_NAME(Raw Source Name.LP)=20231006_MS_HEX-000681_Lipid_Pos-20231006_MS_HEX-000681_Cortex_Lipid_Pos_007.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20231008_MS_HEX-000681_Lipid_Neg-20231008_MS_HEX-000681_Cortex_Lipid_Neg_007.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20231007_MS_HEX-000681_Met_Pos-20231007_MS_HEX-000681_Cortex_Met_Pos_007.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20231008_MS_HEX-000681_Met_Neg-20231008_MS_HEX-000681_Cortex_Met_Neg_007.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20231007_MS_HEX-000681_HALO_Pos-20231007_MS_HEX-000681_Cortex_HALO_Pos_007.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20231010_MS_HEX-000681_GM_Neg-20231010_MS_HEX-000681_Cortex_GM_Neg_007.mzML
SUBJECT_SAMPLE_FACTORS           	Cortex_15	HSA-000034478	genotype:HET KO ATP13A2 | Sample source:brain	sex=Male; age=4.5; age_unit=month; region=Cortex; RAW_FILE_NAME(Raw Source Name.PITC)=20231013_MS_HEX-000681_PITC_Pos-20231013_MS_HEX-000681_Cortex_PITC_Pos_008.mzML; RAW_FILE_NAME(Raw Source Name.LP)=20231006_MS_HEX-000681_Lipid_Pos-20231006_MS_HEX-000681_Cortex_Lipid_Pos_008.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20231008_MS_HEX-000681_Lipid_Neg-20231008_MS_HEX-000681_Cortex_Lipid_Neg_008.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20231007_MS_HEX-000681_Met_Pos-20231007_MS_HEX-000681_Cortex_Met_Pos_008.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20231008_MS_HEX-000681_Met_Neg-20231008_MS_HEX-000681_Cortex_Met_Neg_008.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20231007_MS_HEX-000681_HALO_Pos-20231007_MS_HEX-000681_Cortex_HALO_Pos_008.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20231010_MS_HEX-000681_GM_Neg-20231010_MS_HEX-000681_Cortex_GM_Neg_008.mzML
SUBJECT_SAMPLE_FACTORS           	Cortex_08	HSA-000034471	genotype:HOM KO ATP13A2 | Sample source:brain	sex=Female; age=4.5; age_unit=month; region=Cortex; RAW_FILE_NAME(Raw Source Name.PITC)=20231013_MS_HEX-000681_PITC_Pos-20231013_MS_HEX-000681_Cortex_PITC_Pos_009.mzML; RAW_FILE_NAME(Raw Source Name.LP)=20231006_MS_HEX-000681_Lipid_Pos-20231006_MS_HEX-000681_Cortex_Lipid_Pos_009.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20231008_MS_HEX-000681_Lipid_Neg-20231008_MS_HEX-000681_Cortex_Lipid_Neg_009.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20231007_MS_HEX-000681_Met_Pos-20231007_MS_HEX-000681_Cortex_Met_Pos_009.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20231008_MS_HEX-000681_Met_Neg-20231008_MS_HEX-000681_Cortex_Met_Neg_009.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20231007_MS_HEX-000681_HALO_Pos-20231007_MS_HEX-000681_Cortex_HALO_Pos_009.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20231010_MS_HEX-000681_GM_Neg-20231010_MS_HEX-000681_Cortex_GM_Neg_009.mzML
SUBJECT_SAMPLE_FACTORS           	Cortex_03	HSA-000034466	genotype:HET KO ATP13A2 | Sample source:brain	sex=Male; age=4.5; age_unit=month; region=Cortex; RAW_FILE_NAME(Raw Source Name.PITC)=20231013_MS_HEX-000681_PITC_Pos-20231013_MS_HEX-000681_Cortex_PITC_Pos_010.mzML; RAW_FILE_NAME(Raw Source Name.LP)=20231006_MS_HEX-000681_Lipid_Pos-20231006_MS_HEX-000681_Cortex_Lipid_Pos_010.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20231008_MS_HEX-000681_Lipid_Neg-20231008_MS_HEX-000681_Cortex_Lipid_Neg_010.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20231007_MS_HEX-000681_Met_Pos-20231007_MS_HEX-000681_Cortex_Met_Pos_010.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20231008_MS_HEX-000681_Met_Neg-20231008_MS_HEX-000681_Cortex_Met_Neg_010.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20231007_MS_HEX-000681_HALO_Pos-20231007_MS_HEX-000681_Cortex_HALO_Pos_010.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20231010_MS_HEX-000681_GM_Neg-20231010_MS_HEX-000681_Cortex_GM_Neg_010.mzML
SUBJECT_SAMPLE_FACTORS           	Cortex_14	HSA-000034477	genotype:HOM KO ATP13A2 | Sample source:brain	sex=Female; age=4.5; age_unit=month; region=Cortex; RAW_FILE_NAME(Raw Source Name.PITC)=20231013_MS_HEX-000681_PITC_Pos-20231013_MS_HEX-000681_Cortex_PITC_Pos_011.mzML; RAW_FILE_NAME(Raw Source Name.LP)=20231006_MS_HEX-000681_Lipid_Pos-20231006_MS_HEX-000681_Cortex_Lipid_Pos_011.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20231008_MS_HEX-000681_Lipid_Neg-20231008_MS_HEX-000681_Cortex_Lipid_Neg_011.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20231007_MS_HEX-000681_Met_Pos-20231007_MS_HEX-000681_Cortex_Met_Pos_011.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20231008_MS_HEX-000681_Met_Neg-20231008_MS_HEX-000681_Cortex_Met_Neg_011.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20231007_MS_HEX-000681_HALO_Pos-20231007_MS_HEX-000681_Cortex_HALO_Pos_011.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20231010_MS_HEX-000681_GM_Neg-20231010_MS_HEX-000681_Cortex_GM_Neg_011.mzML
SUBJECT_SAMPLE_FACTORS           	Cortex_pool-2	HSA-000035023	genotype:NA | Sample source:brain	sex=NA; age=4.5; age_unit=month; region=Cortex; RAW_FILE_NAME(Raw Source Name.PITC)=20231013_MS_HEX-000681_PITC_Pos-20231013_MS_HEX-000681_Cortex_PITC_Pos_012.mzML; RAW_FILE_NAME(Raw Source Name.LP)=20231006_MS_HEX-000681_Lipid_Pos-20231006_MS_HEX-000681_Cortex_Lipid_Pos_012.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20231008_MS_HEX-000681_Lipid_Neg-20231008_MS_HEX-000681_Cortex_Lipid_Neg_012.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20231007_MS_HEX-000681_Met_Pos-20231007_MS_HEX-000681_Cortex_Met_Pos_012.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20231008_MS_HEX-000681_Met_Neg-20231008_MS_HEX-000681_Cortex_Met_Neg_012.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20231007_MS_HEX-000681_HALO_Pos-20231007_MS_HEX-000681_Cortex_HALO_Pos_012.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20231010_MS_HEX-000681_GM_Neg-20231010_MS_HEX-000681_Cortex_GM_Neg_012.mzML
SUBJECT_SAMPLE_FACTORS           	Cortex_17	HSA-000034480	genotype:HOM KO ATP13A2 | Sample source:brain	sex=Female; age=4.5; age_unit=month; region=Cortex; RAW_FILE_NAME(Raw Source Name.PITC)=20231013_MS_HEX-000681_PITC_Pos-20231013_MS_HEX-000681_Cortex_PITC_Pos_013.mzML; RAW_FILE_NAME(Raw Source Name.LP)=20231006_MS_HEX-000681_Lipid_Pos-20231006_MS_HEX-000681_Cortex_Lipid_Pos_013.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20231008_MS_HEX-000681_Lipid_Neg-20231008_MS_HEX-000681_Cortex_Lipid_Neg_013.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20231007_MS_HEX-000681_Met_Pos-20231007_MS_HEX-000681_Cortex_Met_Pos_013.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20231008_MS_HEX-000681_Met_Neg-20231008_MS_HEX-000681_Cortex_Met_Neg_013.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20231007_MS_HEX-000681_HALO_Pos-20231007_MS_HEX-000681_Cortex_HALO_Pos_013.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20231010_MS_HEX-000681_GM_Neg-20231010_MS_HEX-000681_Cortex_GM_Neg_013.mzML
SUBJECT_SAMPLE_FACTORS           	Cortex_11	HSA-000034474	genotype:HOM KO ATP13A2 | Sample source:brain	sex=Female; age=4.5; age_unit=month; region=Cortex; RAW_FILE_NAME(Raw Source Name.PITC)=20231013_MS_HEX-000681_PITC_Pos-20231013_MS_HEX-000681_Cortex_PITC_Pos_014.mzML; RAW_FILE_NAME(Raw Source Name.LP)=20231006_MS_HEX-000681_Lipid_Pos-20231006_MS_HEX-000681_Cortex_Lipid_Pos_014.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20231008_MS_HEX-000681_Lipid_Neg-20231008_MS_HEX-000681_Cortex_Lipid_Neg_014.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20231007_MS_HEX-000681_Met_Pos-20231007_MS_HEX-000681_Cortex_Met_Pos_014.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20231008_MS_HEX-000681_Met_Neg-20231008_MS_HEX-000681_Cortex_Met_Neg_014.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20231007_MS_HEX-000681_HALO_Pos-20231007_MS_HEX-000681_Cortex_HALO_Pos_014.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20231010_MS_HEX-000681_GM_Neg-20231010_MS_HEX-000681_Cortex_GM_Neg_014.mzML
SUBJECT_SAMPLE_FACTORS           	Cortex_12	HSA-000034475	genotype:HET KO ATP13A2 | Sample source:brain	sex=Male; age=4.5; age_unit=month; region=Cortex; RAW_FILE_NAME(Raw Source Name.PITC)=20231013_MS_HEX-000681_PITC_Pos-20231013_MS_HEX-000681_Cortex_PITC_Pos_015.mzML; RAW_FILE_NAME(Raw Source Name.LP)=20231006_MS_HEX-000681_Lipid_Pos-20231006_MS_HEX-000681_Cortex_Lipid_Pos_015.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20231008_MS_HEX-000681_Lipid_Neg-20231008_MS_HEX-000681_Cortex_Lipid_Neg_015.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20231007_MS_HEX-000681_Met_Pos-20231007_MS_HEX-000681_Cortex_Met_Pos_015.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20231008_MS_HEX-000681_Met_Neg-20231008_MS_HEX-000681_Cortex_Met_Neg_015.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20231007_MS_HEX-000681_HALO_Pos-20231007_MS_HEX-000681_Cortex_HALO_Pos_015.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20231010_MS_HEX-000681_GM_Neg-20231010_MS_HEX-000681_Cortex_GM_Neg_015.mzML
SUBJECT_SAMPLE_FACTORS           	Cortex_01	HSA-000034464	genotype:WT | Sample source:brain	sex=Female; age=4.5; age_unit=month; region=Cortex; RAW_FILE_NAME(Raw Source Name.PITC)=20231013_MS_HEX-000681_PITC_Pos-20231013_MS_HEX-000681_Cortex_PITC_Pos_016.mzML; RAW_FILE_NAME(Raw Source Name.LP)=20231006_MS_HEX-000681_Lipid_Pos-20231006_MS_HEX-000681_Cortex_Lipid_Pos_016.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20231008_MS_HEX-000681_Lipid_Neg-20231008_MS_HEX-000681_Cortex_Lipid_Neg_016.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20231007_MS_HEX-000681_Met_Pos-20231007_MS_HEX-000681_Cortex_Met_Pos_016.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20231008_MS_HEX-000681_Met_Neg-20231008_MS_HEX-000681_Cortex_Met_Neg_016.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20231007_MS_HEX-000681_HALO_Pos-20231007_MS_HEX-000681_Cortex_HALO_Pos_016.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20231010_MS_HEX-000681_GM_Neg-20231010_MS_HEX-000681_Cortex_GM_Neg_016.mzML
SUBJECT_SAMPLE_FACTORS           	Cortex_13	HSA-000034476	genotype:WT | Sample source:brain	sex=Male; age=4.5; age_unit=month; region=Cortex; RAW_FILE_NAME(Raw Source Name.PITC)=20231013_MS_HEX-000681_PITC_Pos-20231013_MS_HEX-000681_Cortex_PITC_Pos_017.mzML; RAW_FILE_NAME(Raw Source Name.LP)=20231006_MS_HEX-000681_Lipid_Pos-20231006_MS_HEX-000681_Cortex_Lipid_Pos_017.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20231008_MS_HEX-000681_Lipid_Neg-20231008_MS_HEX-000681_Cortex_Lipid_Neg_017.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20231007_MS_HEX-000681_Met_Pos-20231007_MS_HEX-000681_Cortex_Met_Pos_017.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20231008_MS_HEX-000681_Met_Neg-20231008_MS_HEX-000681_Cortex_Met_Neg_017.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20231007_MS_HEX-000681_HALO_Pos-20231007_MS_HEX-000681_Cortex_HALO_Pos_017.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20231010_MS_HEX-000681_GM_Neg-20231010_MS_HEX-000681_Cortex_GM_Neg_017.mzML
SUBJECT_SAMPLE_FACTORS           	Cortex_19	HSA-000034482	genotype:WT | Sample source:brain	sex=Female; age=4.5; age_unit=month; region=Cortex; RAW_FILE_NAME(Raw Source Name.PITC)=20231013_MS_HEX-000681_PITC_Pos-20231013_MS_HEX-000681_Cortex_PITC_Pos_018.mzML; RAW_FILE_NAME(Raw Source Name.LP)=20231006_MS_HEX-000681_Lipid_Pos-20231006_MS_HEX-000681_Cortex_Lipid_Pos_018.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20231008_MS_HEX-000681_Lipid_Neg-20231008_MS_HEX-000681_Cortex_Lipid_Neg_018.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20231007_MS_HEX-000681_Met_Pos-20231007_MS_HEX-000681_Cortex_Met_Pos_018.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20231008_MS_HEX-000681_Met_Neg-20231008_MS_HEX-000681_Cortex_Met_Neg_018.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20231007_MS_HEX-000681_HALO_Pos-20231007_MS_HEX-000681_Cortex_HALO_Pos_018.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20231010_MS_HEX-000681_GM_Neg-20231010_MS_HEX-000681_Cortex_GM_Neg_018.mzML
SUBJECT_SAMPLE_FACTORS           	Cortex_02	HSA-000034465	genotype:HOM KO ATP13A2 | Sample source:brain	sex=Male; age=4.5; age_unit=month; region=Cortex; RAW_FILE_NAME(Raw Source Name.PITC)=20231013_MS_HEX-000681_PITC_Pos-20231013_MS_HEX-000681_Cortex_PITC_Pos_019.mzML; RAW_FILE_NAME(Raw Source Name.LP)=20231006_MS_HEX-000681_Lipid_Pos-20231006_MS_HEX-000681_Cortex_Lipid_Pos_019.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20231008_MS_HEX-000681_Lipid_Neg-20231008_MS_HEX-000681_Cortex_Lipid_Neg_019.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20231007_MS_HEX-000681_Met_Pos-20231007_MS_HEX-000681_Cortex_Met_Pos_019.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20231008_MS_HEX-000681_Met_Neg-20231008_MS_HEX-000681_Cortex_Met_Neg_019.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20231007_MS_HEX-000681_HALO_Pos-20231007_MS_HEX-000681_Cortex_HALO_Pos_019.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20231010_MS_HEX-000681_GM_Neg-20231010_MS_HEX-000681_Cortex_GM_Neg_019.mzML
SUBJECT_SAMPLE_FACTORS           	Cortex_05	HSA-000034468	genotype:HOM KO ATP13A2 | Sample source:brain	sex=Male; age=4.5; age_unit=month; region=Cortex; RAW_FILE_NAME(Raw Source Name.PITC)=20231013_MS_HEX-000681_PITC_Pos-20231013_MS_HEX-000681_Cortex_PITC_Pos_020.mzML; RAW_FILE_NAME(Raw Source Name.LP)=20231006_MS_HEX-000681_Lipid_Pos-20231006_MS_HEX-000681_Cortex_Lipid_Pos_020.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20231008_MS_HEX-000681_Lipid_Neg-20231008_MS_HEX-000681_Cortex_Lipid_Neg_020.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20231007_MS_HEX-000681_Met_Pos-20231007_MS_HEX-000681_Cortex_Met_Pos_020.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20231008_MS_HEX-000681_Met_Neg-20231008_MS_HEX-000681_Cortex_Met_Neg_020.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20231007_MS_HEX-000681_HALO_Pos-20231007_MS_HEX-000681_Cortex_HALO_Pos_020.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20231010_MS_HEX-000681_GM_Neg-20231010_MS_HEX-000681_Cortex_GM_Neg_020.mzML
SUBJECT_SAMPLE_FACTORS           	Cortex_10	HSA-000034473	genotype:WT | Sample source:brain	sex=Male; age=4.5; age_unit=month; region=Cortex; RAW_FILE_NAME(Raw Source Name.PITC)=20231013_MS_HEX-000681_PITC_Pos-20231013_MS_HEX-000681_Cortex_PITC_Pos_021.mzML; RAW_FILE_NAME(Raw Source Name.LP)=20231006_MS_HEX-000681_Lipid_Pos-20231006_MS_HEX-000681_Cortex_Lipid_Pos_021.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20231008_MS_HEX-000681_Lipid_Neg-20231008_MS_HEX-000681_Cortex_Lipid_Neg_021.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20231007_MS_HEX-000681_Met_Pos-20231007_MS_HEX-000681_Cortex_Met_Pos_021.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20231008_MS_HEX-000681_Met_Neg-20231008_MS_HEX-000681_Cortex_Met_Neg_021.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20231007_MS_HEX-000681_HALO_Pos-20231007_MS_HEX-000681_Cortex_HALO_Pos_021.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20231010_MS_HEX-000681_GM_Neg-20231010_MS_HEX-000681_Cortex_GM_Neg_021.mzML
SUBJECT_SAMPLE_FACTORS           	Cortex_06	HSA-000034469	genotype:HET KO ATP13A2 | Sample source:brain	sex=Male; age=4.5; age_unit=month; region=Cortex; RAW_FILE_NAME(Raw Source Name.PITC)=20231013_MS_HEX-000681_PITC_Pos-20231013_MS_HEX-000681_Cortex_PITC_Pos_022.mzML; RAW_FILE_NAME(Raw Source Name.LP)=20231006_MS_HEX-000681_Lipid_Pos-20231006_MS_HEX-000681_Cortex_Lipid_Pos_022.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20231008_MS_HEX-000681_Lipid_Neg-20231008_MS_HEX-000681_Cortex_Lipid_Neg_022.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20231007_MS_HEX-000681_Met_Pos-20231007_MS_HEX-000681_Cortex_Met_Pos_022.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20231008_MS_HEX-000681_Met_Neg-20231008_MS_HEX-000681_Cortex_Met_Neg_022.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20231007_MS_HEX-000681_HALO_Pos-20231007_MS_HEX-000681_Cortex_HALO_Pos_022.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20231010_MS_HEX-000681_GM_Neg-20231010_MS_HEX-000681_Cortex_GM_Neg_022.mzML
SUBJECT_SAMPLE_FACTORS           	Cortex_pool-3	HSA-000035024	genotype:NA | Sample source:brain	sex=NA; age=4.5; age_unit=month; region=Cortex; RAW_FILE_NAME(Raw Source Name.PITC)=20231013_MS_HEX-000681_PITC_Pos-20231013_MS_HEX-000681_Cortex_PITC_Pos_023.mzML; RAW_FILE_NAME(Raw Source Name.LP)=20231006_MS_HEX-000681_Lipid_Pos-20231006_MS_HEX-000681_Cortex_Lipid_Pos_023.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20231008_MS_HEX-000681_Lipid_Neg-20231008_MS_HEX-000681_Cortex_Lipid_Neg_023.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20231007_MS_HEX-000681_Met_Pos-20231007_MS_HEX-000681_Cortex_Met_Pos_023.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20231008_MS_HEX-000681_Met_Neg-20231008_MS_HEX-000681_Cortex_Met_Neg_023.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20231007_MS_HEX-000681_HALO_Pos-20231007_MS_HEX-000681_Cortex_HALO_Pos_023.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20231010_MS_HEX-000681_GM_Neg-20231010_MS_HEX-000681_Cortex_GM_Neg_023.mzML
SUBJECT_SAMPLE_FACTORS           	Hipp_pool-1	HSA-000034505	genotype:NA | Sample source:brain	sex=NA; age=4.5; age_unit=month; region=Hippocampus; RAW_FILE_NAME(Raw Source Name.PITC)=20231013_MS_HEX-000681_PITC_Pos-20231013_MS_HEX-000681_HC_PITC_Pos_001.mzML; RAW_FILE_NAME(Raw Source Name.LP)=20231006_MS_HEX-000681_Lipid_Pos-20231006_MS_HEX-000681_HC_Lipid_Pos_001.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20231008_MS_HEX-000681_Lipid_Neg-20231008_MS_HEX-000681_HC_Lipid_Neg_001.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20231007_MS_HEX-000681_Met_Pos-20231007_MS_HEX-000681_HC_Met_Pos_001.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20231008_MS_HEX-000681_Met_Neg-20231008_MS_HEX-000681_HC_Met_Neg_001.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20231007_MS_HEX-000681_HALO_Pos-20231007_MS_HEX-000681_HC_HALO_Pos_001.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20231010_MS_HEX-000681_GM_Neg-20231010_MS_HEX-000681_HC_GM_Neg_001.mzML
SUBJECT_SAMPLE_FACTORS           	Hipp_18	HSA-000034502	genotype:HET KO ATP13A2 | Sample source:brain	sex=Female; age=4.5; age_unit=month; region=Hippocampus; RAW_FILE_NAME(Raw Source Name.PITC)=20231013_MS_HEX-000681_PITC_Pos-20231013_MS_HEX-000681_HC_PITC_Pos_002.mzML; RAW_FILE_NAME(Raw Source Name.LP)=20231006_MS_HEX-000681_Lipid_Pos-20231006_MS_HEX-000681_HC_Lipid_Pos_002.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20231008_MS_HEX-000681_Lipid_Neg-20231008_MS_HEX-000681_HC_Lipid_Neg_002.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20231007_MS_HEX-000681_Met_Pos-20231007_MS_HEX-000681_HC_Met_Pos_002.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20231008_MS_HEX-000681_Met_Neg-20231008_MS_HEX-000681_HC_Met_Neg_002.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20231007_MS_HEX-000681_HALO_Pos-20231007_MS_HEX-000681_HC_HALO_Pos_002.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20231010_MS_HEX-000681_GM_Neg-20231010_MS_HEX-000681_HC_GM_Neg_002.mzML
SUBJECT_SAMPLE_FACTORS           	Hipp_06	HSA-000034490	genotype:HET KO ATP13A2 | Sample source:brain	sex=Male; age=4.5; age_unit=month; region=Hippocampus; RAW_FILE_NAME(Raw Source Name.PITC)=20231013_MS_HEX-000681_PITC_Pos-20231013_MS_HEX-000681_HC_PITC_Pos_003.mzML; RAW_FILE_NAME(Raw Source Name.LP)=20231006_MS_HEX-000681_Lipid_Pos-20231006_MS_HEX-000681_HC_Lipid_Pos_003.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20231008_MS_HEX-000681_Lipid_Neg-20231008_MS_HEX-000681_HC_Lipid_Neg_003.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20231007_MS_HEX-000681_Met_Pos-20231007_MS_HEX-000681_HC_Met_Pos_003.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20231008_MS_HEX-000681_Met_Neg-20231008_MS_HEX-000681_HC_Met_Neg_003.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20231007_MS_HEX-000681_HALO_Pos-20231007_MS_HEX-000681_HC_HALO_Pos_003.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20231010_MS_HEX-000681_GM_Neg-20231010_MS_HEX-000681_HC_GM_Neg_003.mzML
SUBJECT_SAMPLE_FACTORS           	Hipp_05	HSA-000034489	genotype:HOM KO ATP13A2 | Sample source:brain	sex=Male; age=4.5; age_unit=month; region=Hippocampus; RAW_FILE_NAME(Raw Source Name.PITC)=20231013_MS_HEX-000681_PITC_Pos-20231013_MS_HEX-000681_HC_PITC_Pos_004.mzML; RAW_FILE_NAME(Raw Source Name.LP)=20231006_MS_HEX-000681_Lipid_Pos-20231006_MS_HEX-000681_HC_Lipid_Pos_004.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20231008_MS_HEX-000681_Lipid_Neg-20231008_MS_HEX-000681_HC_Lipid_Neg_004.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20231007_MS_HEX-000681_Met_Pos-20231007_MS_HEX-000681_HC_Met_Pos_004.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20231008_MS_HEX-000681_Met_Neg-20231008_MS_HEX-000681_HC_Met_Neg_004.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20231007_MS_HEX-000681_HALO_Pos-20231007_MS_HEX-000681_HC_HALO_Pos_004.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20231010_MS_HEX-000681_GM_Neg-20231010_MS_HEX-000681_HC_GM_Neg_004.mzML
SUBJECT_SAMPLE_FACTORS           	Hipp_16	HSA-000034500	genotype:WT | Sample source:brain	sex=Female; age=4.5; age_unit=month; region=Hippocampus; RAW_FILE_NAME(Raw Source Name.PITC)=20231013_MS_HEX-000681_PITC_Pos-20231013_MS_HEX-000681_HC_PITC_Pos_005.mzML; RAW_FILE_NAME(Raw Source Name.LP)=20231006_MS_HEX-000681_Lipid_Pos-20231006_MS_HEX-000681_HC_Lipid_Pos_005.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20231008_MS_HEX-000681_Lipid_Neg-20231008_MS_HEX-000681_HC_Lipid_Neg_005.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20231007_MS_HEX-000681_Met_Pos-20231007_MS_HEX-000681_HC_Met_Pos_005.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20231008_MS_HEX-000681_Met_Neg-20231008_MS_HEX-000681_HC_Met_Neg_005.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20231007_MS_HEX-000681_HALO_Pos-20231007_MS_HEX-000681_HC_HALO_Pos_005.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20231010_MS_HEX-000681_GM_Neg-20231010_MS_HEX-000681_HC_GM_Neg_005.mzML
SUBJECT_SAMPLE_FACTORS           	Hipp_08	HSA-000034492	genotype:HOM KO ATP13A2 | Sample source:brain	sex=Female; age=4.5; age_unit=month; region=Hippocampus; RAW_FILE_NAME(Raw Source Name.PITC)=20231013_MS_HEX-000681_PITC_Pos-20231013_MS_HEX-000681_HC_PITC_Pos_006.mzML; RAW_FILE_NAME(Raw Source Name.LP)=20231006_MS_HEX-000681_Lipid_Pos-20231006_MS_HEX-000681_HC_Lipid_Pos_006.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20231008_MS_HEX-000681_Lipid_Neg-20231008_MS_HEX-000681_HC_Lipid_Neg_006.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20231007_MS_HEX-000681_Met_Pos-20231007_MS_HEX-000681_HC_Met_Pos_006.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20231008_MS_HEX-000681_Met_Neg-20231008_MS_HEX-000681_HC_Met_Neg_006.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20231007_MS_HEX-000681_HALO_Pos-20231007_MS_HEX-000681_HC_HALO_Pos_006.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20231010_MS_HEX-000681_GM_Neg-20231010_MS_HEX-000681_HC_GM_Neg_006.mzML
SUBJECT_SAMPLE_FACTORS           	Hipp_03	HSA-000034487	genotype:HET KO ATP13A2 | Sample source:brain	sex=Male; age=4.5; age_unit=month; region=Hippocampus; RAW_FILE_NAME(Raw Source Name.PITC)=20231013_MS_HEX-000681_PITC_Pos-20231013_MS_HEX-000681_HC_PITC_Pos_007.mzML; RAW_FILE_NAME(Raw Source Name.LP)=20231006_MS_HEX-000681_Lipid_Pos-20231006_MS_HEX-000681_HC_Lipid_Pos_007.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20231008_MS_HEX-000681_Lipid_Neg-20231008_MS_HEX-000681_HC_Lipid_Neg_007.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20231007_MS_HEX-000681_Met_Pos-20231007_MS_HEX-000681_HC_Met_Pos_007.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20231008_MS_HEX-000681_Met_Neg-20231008_MS_HEX-000681_HC_Met_Neg_007.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20231007_MS_HEX-000681_HALO_Pos-20231007_MS_HEX-000681_HC_HALO_Pos_007.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20231010_MS_HEX-000681_GM_Neg-20231010_MS_HEX-000681_HC_GM_Neg_007.mzML
SUBJECT_SAMPLE_FACTORS           	Hipp_01	HSA-000034485	genotype:WT | Sample source:brain	sex=Female; age=4.5; age_unit=month; region=Hippocampus; RAW_FILE_NAME(Raw Source Name.PITC)=20231013_MS_HEX-000681_PITC_Pos-20231013_MS_HEX-000681_HC_PITC_Pos_008.mzML; RAW_FILE_NAME(Raw Source Name.LP)=20231006_MS_HEX-000681_Lipid_Pos-20231006_MS_HEX-000681_HC_Lipid_Pos_008.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20231008_MS_HEX-000681_Lipid_Neg-20231008_MS_HEX-000681_HC_Lipid_Neg_008.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20231007_MS_HEX-000681_Met_Pos-20231007_MS_HEX-000681_HC_Met_Pos_008.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20231008_MS_HEX-000681_Met_Neg-20231008_MS_HEX-000681_HC_Met_Neg_008.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20231007_MS_HEX-000681_HALO_Pos-20231007_MS_HEX-000681_HC_HALO_Pos_008.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20231010_MS_HEX-000681_GM_Neg-20231010_MS_HEX-000681_HC_GM_Neg_008.mzML
SUBJECT_SAMPLE_FACTORS           	Hipp_20	HSA-000034504	genotype:HOM KO ATP13A2 | Sample source:brain	sex=Female; age=4.5; age_unit=month; region=Hippocampus; RAW_FILE_NAME(Raw Source Name.PITC)=20231013_MS_HEX-000681_PITC_Pos-20231013_MS_HEX-000681_HC_PITC_Pos_009.mzML; RAW_FILE_NAME(Raw Source Name.LP)=20231006_MS_HEX-000681_Lipid_Pos-20231006_MS_HEX-000681_HC_Lipid_Pos_009.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20231008_MS_HEX-000681_Lipid_Neg-20231008_MS_HEX-000681_HC_Lipid_Neg_009.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20231007_MS_HEX-000681_Met_Pos-20231007_MS_HEX-000681_HC_Met_Pos_009.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20231008_MS_HEX-000681_Met_Neg-20231008_MS_HEX-000681_HC_Met_Neg_009.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20231007_MS_HEX-000681_HALO_Pos-20231007_MS_HEX-000681_HC_HALO_Pos_009.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20231010_MS_HEX-000681_GM_Neg-20231010_MS_HEX-000681_HC_GM_Neg_009.mzML
SUBJECT_SAMPLE_FACTORS           	Hipp_13	HSA-000034497	genotype:WT | Sample source:brain	sex=Male; age=4.5; age_unit=month; region=Hippocampus; RAW_FILE_NAME(Raw Source Name.PITC)=20231013_MS_HEX-000681_PITC_Pos-20231013_MS_HEX-000681_HC_PITC_Pos_010.mzML; RAW_FILE_NAME(Raw Source Name.LP)=20231006_MS_HEX-000681_Lipid_Pos-20231006_MS_HEX-000681_HC_Lipid_Pos_010.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20231008_MS_HEX-000681_Lipid_Neg-20231008_MS_HEX-000681_HC_Lipid_Neg_010.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20231007_MS_HEX-000681_Met_Pos-20231007_MS_HEX-000681_HC_Met_Pos_010.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20231008_MS_HEX-000681_Met_Neg-20231008_MS_HEX-000681_HC_Met_Neg_010.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20231007_MS_HEX-000681_HALO_Pos-20231007_MS_HEX-000681_HC_HALO_Pos_010.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20231010_MS_HEX-000681_GM_Neg-20231010_MS_HEX-000681_HC_GM_Neg_010.mzML
SUBJECT_SAMPLE_FACTORS           	Hipp_pool-2	HSA-000035025	genotype:NA | Sample source:brain	sex=NA; age=4.5; age_unit=month; region=Hippocampus; RAW_FILE_NAME(Raw Source Name.PITC)=20231013_MS_HEX-000681_PITC_Pos-20231013_MS_HEX-000681_HC_PITC_Pos_011.mzML; RAW_FILE_NAME(Raw Source Name.LP)=20231006_MS_HEX-000681_Lipid_Pos-20231006_MS_HEX-000681_HC_Lipid_Pos_011.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20231008_MS_HEX-000681_Lipid_Neg-20231008_MS_HEX-000681_HC_Lipid_Neg_011.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20231007_MS_HEX-000681_Met_Pos-20231007_MS_HEX-000681_HC_Met_Pos_011.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20231008_MS_HEX-000681_Met_Neg-20231008_MS_HEX-000681_HC_Met_Neg_011.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20231007_MS_HEX-000681_HALO_Pos-20231007_MS_HEX-000681_HC_HALO_Pos_011.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20231010_MS_HEX-000681_GM_Neg-20231010_MS_HEX-000681_HC_GM_Neg_011.mzML
SUBJECT_SAMPLE_FACTORS           	Hipp_02	HSA-000034486	genotype:HOM KO ATP13A2 | Sample source:brain	sex=Male; age=4.5; age_unit=month; region=Hippocampus; RAW_FILE_NAME(Raw Source Name.PITC)=20231013_MS_HEX-000681_PITC_Pos-20231013_MS_HEX-000681_HC_PITC_Pos_012.mzML; RAW_FILE_NAME(Raw Source Name.LP)=20231006_MS_HEX-000681_Lipid_Pos-20231006_MS_HEX-000681_HC_Lipid_Pos_012.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20231008_MS_HEX-000681_Lipid_Neg-20231008_MS_HEX-000681_HC_Lipid_Neg_012.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20231007_MS_HEX-000681_Met_Pos-20231007_MS_HEX-000681_HC_Met_Pos_012.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20231008_MS_HEX-000681_Met_Neg-20231008_MS_HEX-000681_HC_Met_Neg_012.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20231007_MS_HEX-000681_HALO_Pos-20231007_MS_HEX-000681_HC_HALO_Pos_012.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20231010_MS_HEX-000681_GM_Neg-20231010_MS_HEX-000681_HC_GM_Neg_012.mzML
SUBJECT_SAMPLE_FACTORS           	Hipp_10	HSA-000034494	genotype:WT | Sample source:brain	sex=Male; age=4.5; age_unit=month; region=Hippocampus; RAW_FILE_NAME(Raw Source Name.PITC)=20231013_MS_HEX-000681_PITC_Pos-20231013_MS_HEX-000681_HC_PITC_Pos_013.mzML; RAW_FILE_NAME(Raw Source Name.LP)=20231006_MS_HEX-000681_Lipid_Pos-20231006_MS_HEX-000681_HC_Lipid_Pos_013.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20231008_MS_HEX-000681_Lipid_Neg-20231008_MS_HEX-000681_HC_Lipid_Neg_013.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20231007_MS_HEX-000681_Met_Pos-20231007_MS_HEX-000681_HC_Met_Pos_013.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20231008_MS_HEX-000681_Met_Neg-20231008_MS_HEX-000681_HC_Met_Neg_013.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20231007_MS_HEX-000681_HALO_Pos-20231007_MS_HEX-000681_HC_HALO_Pos_013.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20231010_MS_HEX-000681_GM_Neg-20231010_MS_HEX-000681_HC_GM_Neg_013.mzML
SUBJECT_SAMPLE_FACTORS           	Hipp_15	HSA-000034499	genotype:HET KO ATP13A2 | Sample source:brain	sex=Male; age=4.5; age_unit=month; region=Hippocampus; RAW_FILE_NAME(Raw Source Name.PITC)=20231013_MS_HEX-000681_PITC_Pos-20231013_MS_HEX-000681_HC_PITC_Pos_014.mzML; RAW_FILE_NAME(Raw Source Name.LP)=20231006_MS_HEX-000681_Lipid_Pos-20231006_MS_HEX-000681_HC_Lipid_Pos_014.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20231008_MS_HEX-000681_Lipid_Neg-20231008_MS_HEX-000681_HC_Lipid_Neg_014.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20231007_MS_HEX-000681_Met_Pos-20231007_MS_HEX-000681_HC_Met_Pos_014.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20231008_MS_HEX-000681_Met_Neg-20231008_MS_HEX-000681_HC_Met_Neg_014.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20231007_MS_HEX-000681_HALO_Pos-20231007_MS_HEX-000681_HC_HALO_Pos_014.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20231010_MS_HEX-000681_GM_Neg-20231010_MS_HEX-000681_HC_GM_Neg_014.mzML
SUBJECT_SAMPLE_FACTORS           	Hipp_14	HSA-000034498	genotype:HOM KO ATP13A2 | Sample source:brain	sex=Female; age=4.5; age_unit=month; region=Hippocampus; RAW_FILE_NAME(Raw Source Name.PITC)=20231013_MS_HEX-000681_PITC_Pos-20231013_MS_HEX-000681_HC_PITC_Pos_015.mzML; RAW_FILE_NAME(Raw Source Name.LP)=20231006_MS_HEX-000681_Lipid_Pos-20231006_MS_HEX-000681_HC_Lipid_Pos_015.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20231008_MS_HEX-000681_Lipid_Neg-20231008_MS_HEX-000681_HC_Lipid_Neg_015.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20231007_MS_HEX-000681_Met_Pos-20231007_MS_HEX-000681_HC_Met_Pos_015.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20231008_MS_HEX-000681_Met_Neg-20231008_MS_HEX-000681_HC_Met_Neg_015.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20231007_MS_HEX-000681_HALO_Pos-20231007_MS_HEX-000681_HC_HALO_Pos_015.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20231010_MS_HEX-000681_GM_Neg-20231010_MS_HEX-000681_HC_GM_Neg_015.mzML
SUBJECT_SAMPLE_FACTORS           	Hipp_11	HSA-000034495	genotype:HOM KO ATP13A2 | Sample source:brain	sex=Female; age=4.5; age_unit=month; region=Hippocampus; RAW_FILE_NAME(Raw Source Name.PITC)=20231013_MS_HEX-000681_PITC_Pos-20231013_MS_HEX-000681_HC_PITC_Pos_016.mzML; RAW_FILE_NAME(Raw Source Name.LP)=20231006_MS_HEX-000681_Lipid_Pos-20231006_MS_HEX-000681_HC_Lipid_Pos_016.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20231008_MS_HEX-000681_Lipid_Neg-20231008_MS_HEX-000681_HC_Lipid_Neg_016.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20231007_MS_HEX-000681_Met_Pos-20231007_MS_HEX-000681_HC_Met_Pos_016.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20231008_MS_HEX-000681_Met_Neg-20231008_MS_HEX-000681_HC_Met_Neg_016.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20231007_MS_HEX-000681_HALO_Pos-20231007_MS_HEX-000681_HC_HALO_Pos_016.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20231010_MS_HEX-000681_GM_Neg-20231010_MS_HEX-000681_HC_GM_Neg_016.mzML
SUBJECT_SAMPLE_FACTORS           	Hipp_19	HSA-000034503	genotype:WT | Sample source:brain	sex=Female; age=4.5; age_unit=month; region=Hippocampus; RAW_FILE_NAME(Raw Source Name.PITC)=20231013_MS_HEX-000681_PITC_Pos-20231013_MS_HEX-000681_HC_PITC_Pos_017.mzML; RAW_FILE_NAME(Raw Source Name.LP)=20231006_MS_HEX-000681_Lipid_Pos-20231006_MS_HEX-000681_HC_Lipid_Pos_017.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20231008_MS_HEX-000681_Lipid_Neg-20231008_MS_HEX-000681_HC_Lipid_Neg_017.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20231007_MS_HEX-000681_Met_Pos-20231007_MS_HEX-000681_HC_Met_Pos_017.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20231008_MS_HEX-000681_Met_Neg-20231008_MS_HEX-000681_HC_Met_Neg_017.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20231007_MS_HEX-000681_HALO_Pos-20231007_MS_HEX-000681_HC_HALO_Pos_017.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20231010_MS_HEX-000681_GM_Neg-20231010_MS_HEX-000681_HC_GM_Neg_017.mzML
SUBJECT_SAMPLE_FACTORS           	Hipp_09	HSA-000034493	genotype:HET KO ATP13A2 | Sample source:brain	sex=Male; age=4.5; age_unit=month; region=Hippocampus; RAW_FILE_NAME(Raw Source Name.PITC)=20231013_MS_HEX-000681_PITC_Pos-20231013_MS_HEX-000681_HC_PITC_Pos_018.mzML; RAW_FILE_NAME(Raw Source Name.LP)=20231006_MS_HEX-000681_Lipid_Pos-20231006_MS_HEX-000681_HC_Lipid_Pos_018.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20231008_MS_HEX-000681_Lipid_Neg-20231008_MS_HEX-000681_HC_Lipid_Neg_018.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20231007_MS_HEX-000681_Met_Pos-20231007_MS_HEX-000681_HC_Met_Pos_018.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20231008_MS_HEX-000681_Met_Neg-20231008_MS_HEX-000681_HC_Met_Neg_018.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20231007_MS_HEX-000681_HALO_Pos-20231007_MS_HEX-000681_HC_HALO_Pos_018.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20231010_MS_HEX-000681_GM_Neg-20231010_MS_HEX-000681_HC_GM_Neg_018.mzML
SUBJECT_SAMPLE_FACTORS           	Hipp_04	HSA-000034488	genotype:WT | Sample source:brain	sex=Female; age=4.5; age_unit=month; region=Hippocampus; RAW_FILE_NAME(Raw Source Name.PITC)=20231013_MS_HEX-000681_PITC_Pos-20231013_MS_HEX-000681_HC_PITC_Pos_019.mzML; RAW_FILE_NAME(Raw Source Name.LP)=20231006_MS_HEX-000681_Lipid_Pos-20231006_MS_HEX-000681_HC_Lipid_Pos_019.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20231008_MS_HEX-000681_Lipid_Neg-20231008_MS_HEX-000681_HC_Lipid_Neg_019.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20231007_MS_HEX-000681_Met_Pos-20231007_MS_HEX-000681_HC_Met_Pos_019.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20231008_MS_HEX-000681_Met_Neg-20231008_MS_HEX-000681_HC_Met_Neg_019.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20231007_MS_HEX-000681_HALO_Pos-20231007_MS_HEX-000681_HC_HALO_Pos_019.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20231010_MS_HEX-000681_GM_Neg-20231010_MS_HEX-000681_HC_GM_Neg_019.mzML
SUBJECT_SAMPLE_FACTORS           	Hipp_17	HSA-000034501	genotype:HOM KO ATP13A2 | Sample source:brain	sex=Female; age=4.5; age_unit=month; region=Hippocampus; RAW_FILE_NAME(Raw Source Name.PITC)=20231013_MS_HEX-000681_PITC_Pos-20231013_MS_HEX-000681_HC_PITC_Pos_020.mzML; RAW_FILE_NAME(Raw Source Name.LP)=20231006_MS_HEX-000681_Lipid_Pos-20231006_MS_HEX-000681_HC_Lipid_Pos_020.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20231008_MS_HEX-000681_Lipid_Neg-20231008_MS_HEX-000681_HC_Lipid_Neg_020.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20231007_MS_HEX-000681_Met_Pos-20231007_MS_HEX-000681_HC_Met_Pos_020.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20231008_MS_HEX-000681_Met_Neg-20231008_MS_HEX-000681_HC_Met_Neg_020.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20231007_MS_HEX-000681_HALO_Pos-20231007_MS_HEX-000681_HC_HALO_Pos_020.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20231010_MS_HEX-000681_GM_Neg-20231010_MS_HEX-000681_HC_GM_Neg_020.mzML
SUBJECT_SAMPLE_FACTORS           	Hipp_12	HSA-000034496	genotype:HET KO ATP13A2 | Sample source:brain	sex=Male; age=4.5; age_unit=month; region=Hippocampus; RAW_FILE_NAME(Raw Source Name.PITC)=20231013_MS_HEX-000681_PITC_Pos-20231013_MS_HEX-000681_HC_PITC_Pos_021.mzML; RAW_FILE_NAME(Raw Source Name.LP)=20231006_MS_HEX-000681_Lipid_Pos-20231006_MS_HEX-000681_HC_Lipid_Pos_021.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20231008_MS_HEX-000681_Lipid_Neg-20231008_MS_HEX-000681_HC_Lipid_Neg_021.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20231007_MS_HEX-000681_Met_Pos-20231007_MS_HEX-000681_HC_Met_Pos_021.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20231008_MS_HEX-000681_Met_Neg-20231008_MS_HEX-000681_HC_Met_Neg_021.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20231007_MS_HEX-000681_HALO_Pos-20231007_MS_HEX-000681_HC_HALO_Pos_021.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20231010_MS_HEX-000681_GM_Neg-20231010_MS_HEX-000681_HC_GM_Neg_021.mzML
SUBJECT_SAMPLE_FACTORS           	Hipp_07	HSA-000034491	genotype:WT | Sample source:brain	sex=Male; age=4.5; age_unit=month; region=Hippocampus; RAW_FILE_NAME(Raw Source Name.PITC)=20231013_MS_HEX-000681_PITC_Pos-20231013_MS_HEX-000681_HC_PITC_Pos_022.mzML; RAW_FILE_NAME(Raw Source Name.LP)=20231006_MS_HEX-000681_Lipid_Pos-20231006_MS_HEX-000681_HC_Lipid_Pos_022.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20231008_MS_HEX-000681_Lipid_Neg-20231008_MS_HEX-000681_HC_Lipid_Neg_022.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20231007_MS_HEX-000681_Met_Pos-20231007_MS_HEX-000681_HC_Met_Pos_022.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20231008_MS_HEX-000681_Met_Neg-20231008_MS_HEX-000681_HC_Met_Neg_022.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20231007_MS_HEX-000681_HALO_Pos-20231007_MS_HEX-000681_HC_HALO_Pos_022.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20231010_MS_HEX-000681_GM_Neg-20231010_MS_HEX-000681_HC_GM_Neg_022.mzML
SUBJECT_SAMPLE_FACTORS           	Hipp_pool-3	HSA-000035026	genotype:NA | Sample source:brain	sex=NA; age=4.5; age_unit=month; region=Hippocampus; RAW_FILE_NAME(Raw Source Name.PITC)=20231013_MS_HEX-000681_PITC_Pos-20231013_MS_HEX-000681_HC_PITC_Pos_023.mzML; RAW_FILE_NAME(Raw Source Name.LP)=20231006_MS_HEX-000681_Lipid_Pos-20231006_MS_HEX-000681_HC_Lipid_Pos_023.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20231008_MS_HEX-000681_Lipid_Neg-20231008_MS_HEX-000681_HC_Lipid_Neg_023.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20231007_MS_HEX-000681_Met_Pos-20231007_MS_HEX-000681_HC_Met_Pos_023.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20231008_MS_HEX-000681_Met_Neg-20231008_MS_HEX-000681_HC_Met_Neg_023.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20231007_MS_HEX-000681_HALO_Pos-20231007_MS_HEX-000681_HC_HALO_Pos_023.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20231010_MS_HEX-000681_GM_Neg-20231010_MS_HEX-000681_HC_GM_Neg_023.mzML
#COLLECTION
CO:COLLECTION_SUMMARY            	Heterozygous Atp13a2<tm1Pjsch> animals of genotype
CO:COLLECTION_SUMMARY            	B6N.129S6(Cg)-Atp13a2tm1Pjsch/J were obtained from The Jackson Laboratory (JAX
CO:COLLECTION_SUMMARY            	strain 021914)17 and were crossed to generate homozygous Atp13a2 KO (Atp13a2
CO:COLLECTION_SUMMARY            	–/–) animals. For both the 5-month and 15-month-old cohort, female and male
CO:COLLECTION_SUMMARY            	mice were used in comparable percentages (see table below). In case of the
CO:COLLECTION_SUMMARY            	15-month-old Atp13a2 KO cohort, one of the animals died prior to study
CO:COLLECTION_SUMMARY            	conclusion and was excluded. Animals were maintained and all procedures
CO:COLLECTION_SUMMARY            	performed in adherence to ethical regulations and protocols approved by the
CO:COLLECTION_SUMMARY            	Denali Therapeutics Inc. Institutional Animal Care and Use Committee (IACUC).
CO:COLLECTION_SUMMARY            	Mice were housed under a 12-h light/12-h dark cycle and had access to water and
CO:COLLECTION_SUMMARY            	standard rodent diet ad libitum. Running wheels were provided for enrichment to
CO:COLLECTION_SUMMARY            	the cohort that was aged to 15 months.Animals were deeply anesthetized via
CO:COLLECTION_SUMMARY            	intraperitoneal injection of 2.5% Avertin and transcardially perfused with
CO:COLLECTION_SUMMARY            	ice-cold PBS using a peristaltic pump (Gilson Inc. Minipuls Evolution). The
CO:COLLECTION_SUMMARY            	brain was then removed and one hemisphere sub-dissected into the anterior cortex
CO:COLLECTION_SUMMARY            	and hippocampus, while the other was retained without sub-dissection. Tissue
CO:COLLECTION_SUMMARY            	samples were individually weighed, flash frozen on dry ice and stored at -80°C
CO:COLLECTION_SUMMARY            	for subsequent analysis.
CO:SAMPLE_TYPE                   	Brain
CO:STORAGE_CONDITIONS            	-80℃
CO:COLLECTION_VIALS              	Lobind 1.5 mL Eppendorf tubes
CO:STORAGE_VIALS                 	Lobind 1.5 mL Eppendorf tubes
#TREATMENT
TR:TREATMENT_SUMMARY             	No treatment
#SAMPLEPREP
SP:SAMPLEPREP_SUMMARY            	For tissue samples, 20 (± 3) mg of anterior cortex or 15 (± 2) mg of
SP:SAMPLEPREP_SUMMARY            	hippocampus from the left hemisphere of each individual animal was dissected,
SP:SAMPLEPREP_SUMMARY            	weighed and flash frozen during tissue collection. Lipids and metabolites were
SP:SAMPLEPREP_SUMMARY            	extracted from the frozen samples using 400 mL of HPLC-grade methanol (Fisher
SP:SAMPLEPREP_SUMMARY            	Chemical; # A452-4) containing stable-isotope internal standards and homogenized
SP:SAMPLEPREP_SUMMARY            	with a 3 mm tungsten carbide bead for 45 s at 25 Hz on TissueLyzer II (QIAGEN,
SP:SAMPLEPREP_SUMMARY            	#85300). The methanol fraction was isolated via centrifugation (20 min at 4°C,
SP:SAMPLEPREP_SUMMARY            	14,000 x g, transferred to a 96-well sample collection plate (Waters;
SP:SAMPLEPREP_SUMMARY            	#186005837) and incubated for 1 h, at -20°C for protein precipitation,
SP:SAMPLEPREP_SUMMARY            	followed by an additional 20 min centrifugation (4,000 x g at 4°C). The
SP:SAMPLEPREP_SUMMARY            	supernatant was transferred to glass vial plates (Analytical systems, #27350)
SP:SAMPLEPREP_SUMMARY            	for LCMS analysis.
SP:PROCESSING_STORAGE_CONDITIONS 	On ice
SP:EXTRACT_STORAGE               	-20℃
#CHROMATOGRAPHY
CH:CHROMATOGRAPHY_TYPE           	Reversed phase
CH:INSTRUMENT_NAME               	Agilent 1290 Infinity II
CH:COLUMN_NAME                   	Agilent 300 SB-C18 RRHD (100 x 2.1 mm, 1.8um)
CH:SOLVENT_A                     	100% water; 0.2% formic acid
CH:SOLVENT_B                     	100% acetonitrile; 0.2% formic acid
CH:FLOW_GRADIENT                 	0.00–0.25 min at 0% B, 0.25–4.00 min from 0% B to 50% B, 4.00–4.50 min
CH:FLOW_GRADIENT                 	from 50% B to 100% B, 4.50–5.10 min at 100% B, 5.10–5.11 min to 0% B, and
CH:FLOW_GRADIENT                 	5.11–5.79 min at 0% B
CH:FLOW_RATE                     	0.80 mL/min
CH:COLUMN_TEMPERATURE            	20
#ANALYSIS
AN:ANALYSIS_TYPE                 	MS
#MS
MS:INSTRUMENT_NAME               	ABI Sciex 6500+ QTrap
MS:INSTRUMENT_TYPE               	Triple quadrupole
MS:MS_TYPE                       	ESI
MS:ION_MODE                      	POSITIVE
MS:MS_COMMENTS                   	curtain gas 45 psi, ion spray voltage 5,500 V, temperature 500°C, ion source
MS:MS_COMMENTS                   	gas 1 at 60 psi, gas 2 at 70 psi, and collision gas at 8 psi.
#MS_METABOLITE_DATA
MS_METABOLITE_DATA:UNITS	normalized peak area
MS_METABOLITE_DATA_START
Samples	HSA-000038800	HSA-000038799	HSA-000038794	HSA-000038788	HSA-000038797	HSA-000038790	HSA-000038798	HSA-000038795	HSA-000039091	HSA-000038796	HSA-000038791	HSA-000038787	HSA-000038792	HSA-000038793	HSA-000038789	HSA-000039092	HSA-000038814	HSA-000038813	HSA-000038811	HSA-000038804	HSA-000038805	HSA-000038803	HSA-000038802	HSA-000038807	HSA-000039093	HSA-000038809	HSA-000038812	HSA-000038806	HSA-000038801	HSA-000038810	HSA-000038808	HSA-000039094	HSA-000034484	HSA-000034472	HSA-000034470	HSA-000034479	HSA-000034467	HSA-000034483	HSA-000034481	HSA-000034478	HSA-000034471	HSA-000034466	HSA-000034477	HSA-000035023	HSA-000034480	HSA-000034474	HSA-000034475	HSA-000034464	HSA-000034476	HSA-000034482	HSA-000034465	HSA-000034468	HSA-000034473	HSA-000034469	HSA-000035024	HSA-000034505	HSA-000034502	HSA-000034490	HSA-000034489	HSA-000034500	HSA-000034492	HSA-000034487	HSA-000034485	HSA-000034504	HSA-000034497	HSA-000035025	HSA-000034486	HSA-000034494	HSA-000034499	HSA-000034498	HSA-000034495	HSA-000034503	HSA-000034493	HSA-000034488	HSA-000034501	HSA-000034496	HSA-000034491	HSA-000035026
Factors	genotype:WT | Sample source:brain	genotype:HOM KO ATP13A2 | Sample source:brain	genotype:HOM KO ATP13A2 | Sample source:brain	genotype:WT | Sample source:brain	genotype:HOM KO ATP13A2 | Sample source:brain	genotype:HOM KO ATP13A2 | Sample source:brain	genotype:WT | Sample source:brain	genotype:NA | Sample source:brain	genotype:HOM KO ATP13A2 | Sample source:brain	genotype:WT | Sample source:brain	genotype:WT | Sample source:brain	genotype:HOM KO ATP13A2 | Sample source:brain	genotype:WT | Sample source:brain	genotype:WT | Sample source:brain	genotype:NA | Sample source:brain	genotype:NA | Sample source:brain	genotype:WT | Sample source:brain	genotype:WT | Sample source:brain	genotype:HOM KO ATP13A2 | Sample source:brain	genotype:WT | Sample source:brain	genotype:WT | Sample source:brain	genotype:HOM KO ATP13A2 | Sample source:brain	genotype:WT | Sample source:brain	genotype:NA | Sample source:brain	genotype:WT | Sample source:brain	genotype:HOM KO ATP13A2 | Sample source:brain	genotype:HOM KO ATP13A2 | Sample source:brain	genotype:WT | Sample source:brain	genotype:HOM KO ATP13A2 | Sample source:brain	genotype:HOM KO ATP13A2 | Sample source:brain	genotype:NA | Sample source:brain	genotype:NA | Sample source:brain	genotype:NA | Sample source:brain	genotype:HET KO ATP13A2 | Sample source:brain	genotype:WT | Sample source:brain	genotype:WT | Sample source:brain	genotype:WT | Sample source:brain	genotype:HOM KO ATP13A2 | Sample source:brain	genotype:HET KO ATP13A2 | Sample source:brain	genotype:HET KO ATP13A2 | Sample source:brain	genotype:HOM KO ATP13A2 | Sample source:brain	genotype:HET KO ATP13A2 | Sample source:brain	genotype:HOM KO ATP13A2 | Sample source:brain	genotype:NA | Sample source:brain	genotype:HOM KO ATP13A2 | Sample source:brain	genotype:HOM KO ATP13A2 | Sample source:brain	genotype:HET KO ATP13A2 | Sample source:brain	genotype:WT | Sample source:brain	genotype:WT | Sample source:brain	genotype:WT | Sample source:brain	genotype:HOM KO ATP13A2 | Sample source:brain	genotype:HOM KO ATP13A2 | Sample source:brain	genotype:WT | Sample source:brain	genotype:HET KO ATP13A2 | Sample source:brain	genotype:NA | Sample source:brain	genotype:NA | Sample source:brain	genotype:HET KO ATP13A2 | Sample source:brain	genotype:HET KO ATP13A2 | Sample source:brain	genotype:HOM KO ATP13A2 | Sample source:brain	genotype:WT | Sample source:brain	genotype:HOM KO ATP13A2 | Sample source:brain	genotype:HET KO ATP13A2 | Sample source:brain	genotype:WT | Sample source:brain	genotype:HOM KO ATP13A2 | Sample source:brain	genotype:WT | Sample source:brain	genotype:NA | Sample source:brain	genotype:HOM KO ATP13A2 | Sample source:brain	genotype:WT | Sample source:brain	genotype:HET KO ATP13A2 | Sample source:brain	genotype:HOM KO ATP13A2 | Sample source:brain	genotype:HOM KO ATP13A2 | Sample source:brain	genotype:WT | Sample source:brain	genotype:HET KO ATP13A2 | Sample source:brain	genotype:WT | Sample source:brain	genotype:HOM KO ATP13A2 | Sample source:brain	genotype:HET KO ATP13A2 | Sample source:brain	genotype:WT | Sample source:brain	genotype:NA | Sample source:brain
13C3,15N-Cysteine	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.
13C4-Putrescine	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.
13C4-Spermidine	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.
6C13-Phenylalanine	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.
Agmatine	0.815	0.679	0.709	0.764	0.751	0.761	0.659	0.582	0.807	0.844	1.154	0.748	0.677	0.678	0.655	0.854	0.74	0.617	0.711	0.619	0.941	0.496	0.312	0.683	0.685	0.601	0.849	0.61	0.403	0.639	0.691	0.696	0.82	0.691	0.612	0.782	0.958	1.077	1.001	0.967	0.921	0.917	0.89	0.867	1.2	0.905	0.992	0.924	1.258	1.119	0.826	0.983	1.037	0.797	0.988	0.806	0.694	0.833	0.639	0.657	0.936	0.874	0.783	0.837	0.806	0.793	0.78	0.779	0.591	0.786	0.788	0.869	0.818	0.973	0.78	0.945	0.772	0.82
Alanine	21.764	21.673	20.942	19.283	23.01	21.036	24.791	17.704	20.824	24.668	19.83	22.308	20.214	19.144	18.872	21.895	21.226	19.609	21.92	20.031	16.289	13.634	7.305	19.156	21.865	16.683	27.023	19.501	5.927	18.866	20.328	21.802	25.419	18.992	15.277	33.666	31.398	26.85	32.259	25.228	26.695	22.622	29.348	25.715	40.755	34.613	28.702	26.611	36.345	35.326	18.296	28.035	30.477	16.704	25.199	19.389	25.868	19.069	14.22	26.468	24.613	20.643	17.953	22.713	19.915	19.666	17.246	20.883	14.938	23.46	24.653	24.44	20.998	24.955	22.691	21.969	18.546	19.775
Alanine-d4	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.
Arginine	8.821	10.227	8.828	7.879	8.101	7.966	7.815	6.943	8.628	9.739	7.827	9.958	7.291	8.336	8.046	8.387	8.078	7.87	7.146	5.393	5.608	4.498	2.686	6.958	7.939	5.333	11.344	6.387	5.374	6.3	7.842	7.944	5.409	4.313	3.518	6.007	8.941	9.028	6.265	7.451	7.059	6.899	6.898	5.557	10.287	8.98	7.602	8.991	10.886	9.088	5.407	10.547	9.707	3.036	3.648	2.415	1.839	2.748	2.015	2.386	3.841	3.59	2.729	2.968	2.257	2.363	2.703	2.898	1.783	3.324	2.987	2.431	2.713	3.949	2.665	2.762	2.374	2.251
Arginine-d4C13	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.
Aspartic acid	16.376	18.129	16.615	14.693	16.609	15.217	14.487	18.11	16.093	21.798	20.756	18.88	14.552	16.402	14.469	15.612	14.221	12.029	11.914	8.485	12.484	6.332	3.582	10.654	14.805	10.14	23.33	9.526	8.039	11.92	11.068	14.519	22.089	17.019	15.567	24.204	28.949	27.427	23.206	23.623	24.549	22.596	23.889	21.017	32.579	29.117	24.54	26.612	30.263	29.167	18.252	25.06	23.739	16.589	21.543	11.762	11.716	11.607	9.248	11.569	15.9	13.646	12.17	14.314	12.036	11.896	10.992	10.96	9.077	14.947	13.025	15.758	12.307	18.737	15.009	13.676	12.175	11.888
Citrulline	0.109	0.091	0.1	0.082	0.087	0.103	0.105	0.066	0.108	0.112	0.113	0.125	0.091	0.091	0.1	0.109	0.108	0.093	0.087	0.082	0.09	0.083	0.038	0.085	0.099	0.085	0.141	0.079	0.048	0.089	0.111	0.112	0.186	0.155	0.144	0.197	0.269	0.206	0.181	0.205	0.208	0.211	0.211	0.176	0.247	0.221	0.189	0.238	0.209	0.235	0.167	0.191	0.234	0.134	0.181	0.173	0.14	0.15	0.121	0.203	0.209	0.187	0.179	0.156	0.144	0.171	0.156	0.164	0.123	0.175	0.201	0.177	0.168	0.234	0.172	0.144	0.158	0.168
Creatinine	2.345	2.263	2.002	2.114	2.114	2.227	2.333	2.218	2.237	2.58	2.398	2.619	2.098	2.087	2.063	2.174	1.961	2.364	2.192	1.909	1.658	1.436	0.833	2.178	2.152	1.975	2.755	2.051	0.928	2.058	1.944	2.202	1.434	1.141	0.9	1.273	1.936	1.695	1.464	1.526	1.464	1.687	1.361	1.467	1.896	1.565	1.618	1.613	1.992	1.774	1.188	2.165	1.667	0.931	1.01	1.073	0.832	1	0.709	0.891	1.187	1.216	0.928	0.954	1.034	0.891	0.911	1.244	0.685	1.073	0.958	1.127	1.224	1.234	0.972	1.288	0.956	0.883
Creatinine-d3	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.
Cystathionine	0.137	0.147	0.111	0.161	0.133	0.209	0.264	0.096	0.142	0.117	0.233	0.165	0.107	0.156	0.141	0.145	0.187	0.292	0.28	0.255	0.315	0.275	0.243	0.241	0.184	0.219	0.141	0.271	0.239	0.193	0.198	0.187	0.135	0.126	0.105	0.089	0.23	0.241	0.135	0.192	0.136	0.21	0.119	0.116	0.237	0.163	0.22	0.174	0.313	0.26	0.125	0.254	0.267	0.101	0.111	0.176	0.056	0.216	0.12	0.097	0.193	0.219	0.166	0.121	0.191	0.184	0.245	0.243	0.089	0.136	0.163	0.169	0.211	0.244	0.112	0.219	0.169	0.17
Cystathionine-d4	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.
Cysteine	6.991	9.696	7.901	5.45	8.503	5.586	6.636	8.693	7.152	9.127	6.63	8.604	5.218	7.918	4.381	7.094	6.991	7.048	6.463	3.399	6.125	3.515	2.905	5.101	7.454	5.395	12.468	4.061	5.225	6.586	5.83	8.094	1.384	0.994	0.971	0.974	2.087	1.82	1.659	1.606	1.443	1.17	1.321	1.423	2.056	1.467	1.544	1.472	2.681	2.558	1.49	2.044	2.154	1.087	1.599	0.605	0.725	0.955	0.585	0.417	0.916	0.736	0.639	0.739	0.914	0.696	0.774	1.059	0.447	1.033	0.678	0.746	1	1.542	0.741	0.897	0.766	0.637
Cysteinylglycine	0.006	0.016	0.008	0.006	0.006	0.009	0.014	0.005	0.007	0.006	0.003	0.004	0.008	0.009	0.006	0.006	0.003	0.007	0.008	0.006	0.001	0.007	0.008	0.008	0.007	0.007	0.004	0.005	0.008	0.007	0.006	0.007	0.008	0.007	0.006	0.009	0.014	0.01	0.008	0.016	0.011	0.007	0.011	0.01	0.011	0.019	0.011	0.012	0.007	0.019	0.01	0.014	0.008	0.007	0.01	0.005	0.012	0.008	0.009	0.005	0.008	0.007	0.004	0.005	0.007	0.006	0.006	0.008	0.007	0.005	0.009	0.005	0.008	0.013	0.008	0.008	0.005	0.005
Dopa	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.
Dopamine	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.
Glutamic acid	248.595	263.081	228.587	244.596	248.131	240.436	234.502	247.896	264.357	267.261	250.986	261.269	225.763	246.223	223.689	257.186	237.946	216.409	214.194	190.54	202.222	148.49	95.175	203.176	240.598	196.501	267.316	194.423	104.7	218.363	199.454	226.07	235.962	205.116	174.893	212.774	283.358	236.715	252.72	249.174	247.836	253.91	252.775	242.552	324.954	266.808	264.25	289.435	327.381	294.502	238.196	275.803	276.941	252.216	293.457	219.796	209.032	221.818	181.921	193.173	260.995	242.227	235.894	202.169	229.626	212.416	215.721	211.047	173.57	225.7	222.891	239.651	233.825	264.412	231.727	241.76	221.522	221.577
Glutamic acid-d3	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.
Glutamine	110.395	105.194	100.666	111.624	105.338	114.723	97.117	87.732	115.059	121.023	163.638	112.573	98.442	109.743	106.054	114.561	101.82	96.83	102.664	86.432	135.472	66.947	40.434	93.327	105.103	80.384	127.031	93.487	56.234	93.604	99.581	105.606	126.558	98.045	82.861	119.765	163.659	160.396	147.595	142.134	135.034	136.994	134.527	121.839	195.319	147.173	148.6	154.489	206.15	182.31	116.868	167.105	151.493	106.434	126.512	95.566	87.645	101.381	76.65	84.917	119.056	110.867	100.314	106.216	106.61	95.269	96.544	86.026	74.342	105.453	99.081	112.598	96.911	118.706	103.714	106.915	94.377	97.136
Glutathione	6.877	6.735	6.563	6.659	5.906	6.16	6.543	6.209	6.822	5.959	6.199	5.973	6.397	6.404	5.889	6.396	5.526	6.066	6.062	5.383	5.726	5.164	3.677	5.659	6.529	5.22	6.943	5.525	3.99	5.538	5.665	6.882	6.782	7.992	7.296	8.82	8.229	9.775	8.93	8.975	7.128	8.243	8.002	8.816	9.957	10.823	8.681	9.558	9.954	10.897	9.539	9.227	8.171	8.69	9.451	9.26	8.751	7.727	6.634	8.989	9.102	7.917	9.393	8.688	8.741	8.334	8.044	9.323	7.572	9.463	11.348	8.954	9.927	8.951	9.802	9.659	10.81	9.955
Glutathione disulfide	0.01	0.009	0.005	0.007	0.003	0.008	0.004	0.005	0.011	0.004	0.005	0.012	0.009	0.014	0.009	0.005	0.005	0.013	0.027	0.005	0.013	0.004	0.007	0.005	0.002	0.027	0.012	0.008	N.D.	0.01	0.01	0.007	0.005	0.008	0.018	0.015	0.013	0.011	0.011	0.018	0.009	0.007	0.015	0.011	0.025	0.013	0.012	0.022	0.021	0.026	0.008	0.017	0.011	0.011	0.011	0.014	0.01	0.012	0.007	0.005	0.016	0.01	0.014	0.015	0.013	0.012	0.011	0.01	0.003	0.014	0.003	0.012	0.003	0.003	0.004	0.01	0.009	0.012
Glutathione-(glycine-13C2,15N)	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.
Glycine	6.888	6.947	6.611	6.724	7.572	7.05	7.453	7.285	6.979	8.285	6.295	7.301	5.636	6.753	6.353	6.229	7.041	7.23	8.169	5.404	6.203	4.591	2.695	6.091	7.829	6.152	8.825	5.432	5.392	6.381	6.328	6.552	4.987	4.067	3.604	5.117	6.439	6.394	6.187	5.623	5.366	5.046	4.884	5.44	7.351	5.877	5.964	5.918	8.156	7.859	4.227	6.033	6.929	5.308	6.993	5.013	4.559	5.456	3.816	4.446	6.425	5.407	5.512	5.415	5.605	5.036	5.382	6.299	3.866	6.051	6.206	7.248	6.919	7.142	6.297	6.605	5.385	5.83
Histidine	5.196	4.468	4.171	5.439	4.233	5.397	3.987	4.764	4.93	5.334	10.444	4.854	4.053	4.361	4.945	4.283	4.225	3.999	4.486	3.753	6.581	3.3	1.482	3.572	4.109	3.961	5.432	3.789	2.217	3.326	3.975	4.145	3.884	3.219	2.39	4.257	5.407	5.485	3.823	4.668	4.217	4.545	4.425	4.004	6.789	5.799	4.818	5.279	7.317	6.702	3.496	5.19	5.757	3.053	3.329	2.687	1.984	3.12	1.872	2.37	3.396	3.347	2.712	2.531	2.892	2.616	3.169	2.816	1.858	2.581	3.336	3.557	3.215	3.47	3.23	3.162	2.334	3.004
Homocysteine	0.071	0.073	0.071	0.086	0.057	0.054	0.073	0.071	0.072	0.072	0.081	0.072	0.082	0.079	0.058	0.073	0.092	0.075	0.057	0.07	0.108	0.134	0.158	0.051	0.086	0.077	0.077	0.082	0.137	0.077	0.064	0.085	0.034	0.029	0.039	0.027	0.031	0.024	0.036	0.025	0.028	0.022	0.026	0.031	0.025	0.034	0.025	0.027	0.017	0.02	0.038	0.027	0.025	0.035	0.021	0.046	0.027	0.029	0.047	0.034	0.039	0.024	0.036	0.04	0.051	0.043	0.044	0.037	0.037	0.037	0.03	0.034	0.031	0.026	0.024	0.037	0.038	0.025
Homocysteine-d4	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.
Isoleucine	0.604	0.548	0.564	0.513	0.562	0.715	0.467	0.499	0.587	0.576	0.488	0.568	0.582	0.508	0.468	0.629	0.521	0.499	0.52	0.527	0.364	0.341	0.18	0.426	0.51	0.412	0.704	0.481	0.265	0.434	0.524	0.556	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.
Kynurenine	0.003	0.002	0.002	0.001	0.002	0.007	0.002	0.001	0.003	0.003	0.003	0.003	0.003	0.002	0.003	0.005	0.004	0.001	0.001	0.004	0.004	0.004	0.001	0.001	0.003	0.001	0.005	0.003	0.001	0.004	0.004	0.003	0.003	0.003	0.003	0.007	0.009	0.005	0.008	0.004	0.004	0.004	0.005	0.006	0.007	0.008	0.004	0.006	0.005	0.007	0.002	0.005	0.004	0.004	0.002	0.003	0.006	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.
Leucine	0.335	0.289	0.291	0.294	0.303	0.378	0.24	0.257	0.317	0.292	0.274	0.315	0.292	0.264	0.236	0.324	0.279	0.249	0.279	0.257	0.22	0.162	0.095	0.233	0.274	0.218	0.383	0.239	0.157	0.236	0.288	0.278	0.574	0.403	0.341	0.648	0.593	0.771	0.656	0.615	0.556	0.494	0.625	0.557	0.752	0.734	0.559	0.567	0.73	0.732	0.377	0.608	0.588	0.327	0.571	0.388	0.342	0.343	0.276	0.477	0.483	0.383	0.349	0.464	0.371	0.409	0.349	0.361	0.279	0.485	0.477	0.421	0.371	0.48	0.447	0.407	0.363	0.403
Lysine	156.73	159.508	197.572	157.543	178.822	179.869	205.863	146.143	174.558	241.835	174.963	180.358	140.154	158.297	160.919	139.916	185.898	143.771	188.789	107.482	137.859	108.9	66.406	137.153	204.716	133.175	255.245	136.454	94.81	174.099	166.064	186.292	105.688	70.103	63.733	124.338	156.308	163.633	124.549	138.945	115.233	109.575	125.321	109.329	197.975	166.33	119.812	139.919	176.314	181.923	88.518	146.104	149.642	74.453	96.172	74.113	67.281	80.574	51.812	76.065	106.118	89.989	76.731	107.785	70.448	78.248	80.797	79.587	67.249	99.207	103.146	99.636	87.411	111.659	89.153	85.073	70.826	86.939
Methionine	1.646	1.439	1.18	1.182	1.179	1.231	1.441	1.241	1.584	1.662	1.462	2.669	1.086	1.217	1.33	1.555	1.421	1.308	1.08	0.934	1.185	0.9	0.401	1.18	1.294	1.107	1.981	0.956	1.135	1.236	1.145	1.411	1.391	1.101	1.057	1.085	1.631	1.964	1.709	1.485	1.531	1.455	1.536	1.397	2.424	1.639	1.664	1.412	2.351	2.074	1.245	1.817	1.938	1.043	1.466	1.047	0.998	1.055	0.773	0.81	1.479	1.192	0.912	1.293	1.163	1.089	1.082	1.225	0.771	1.22	1.154	1.226	1.218	1.332	1.353	1.266	1.224	1.058
Methionine S-oxide	0.032	0.02	0.017	0.026	0.024	0.016	0.022	0.02	0.029	0.03	0.031	0.041	0.017	0.021	0.028	0.027	0.024	0.022	0.02	0.017	0.022	0.015	0.009	0.021	0.021	0.017	0.035	0.015	0.019	0.021	0.016	0.028	0.056	0.05	0.045	0.036	0.055	0.062	0.061	0.057	0.061	0.061	0.057	0.059	0.069	0.056	0.06	0.063	0.064	0.069	0.049	0.072	0.064	0.048	0.057	0.037	0.041	0.047	0.03	0.034	0.058	0.045	0.04	0.037	0.039	0.037	0.038	0.042	0.033	0.045	0.045	0.045	0.049	0.047	0.047	0.05	0.053	0.039
Methionine-d3	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.
N-Acetylputrescine	1.7	0.993	1.248	1.554	1.478	1.471	1.154	1.157	1.535	1.419	2.433	1.239	1.199	1.38	1.21	1.59	1.418	1.508	1.727	1.321	2.448	1.036	0.681	1.528	1.485	1.403	1.419	1.293	0.75	1.489	1.536	1.396	0.307	152.737	110.926	120.42	211.677	203.558	198.502	155.479	186.23	173.238	149.179	156.393	237.951	167.043	220.637	158.973	286.91	220.372	146.408	142.097	234.051	140.738	200.513	183.601	164.41	160.338	136.427	161.449	248.999	178.082	192.054	253.966	208.715	190.343	177.565	208.946	164.111	197.365	185.68	237.279	160.516	173.305	231.939	196.337	121.946	148.733
N1-Acetylspermidine	0.23	0.179	0.182	0.223	0.18	0.162	0.182	0.205	0.26	0.162	0.161	0.166	0.191	0.13	0.164	0.214	0.217	0.216	0.189	0.187	0.196	0.222	0.265	0.179	0.179	0.208	0.172	0.178	0.255	0.207	0.183	0.225	2.834	0.967	0.746	1.638	1.675	2.873	4.815	2.08	2.646	1.696	2.538	2.235	3.439	2.849	1.63	1.365	2.668	1.854	2.23	2.371	1.791	1.897	3.292	3.156	4.908	1.75	1.844	1.988	4.015	1.819	1.856	5.449	1.928	2.83	3.189	1.601	1.915	3.6	3.755	1.662	2.308	2.051	2.873	1.518	1.744	1.676
N1-Acetylspermine	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.
Ornithine	0.22	0.23	0.242	0.197	0.207	0.245	0.295	0.22	0.247	0.226	0.224	0.297	0.211	0.232	0.28	0.254	0.244	0.268	0.249	0.213	0.176	0.155	0.096	0.22	0.199	0.186	0.281	0.212	0.168	0.173	0.249	0.253	0.276	0.202	0.194	0.339	0.369	0.398	0.343	0.343	0.275	0.274	0.309	0.312	0.406	0.418	0.363	0.378	0.427	0.446	0.227	0.383	0.358	0.149	0.277	0.219	0.18	0.237	0.134	0.273	0.29	0.283	0.213	0.236	0.171	0.218	0.223	0.248	0.141	0.253	0.252	0.265	0.276	0.295	0.215	0.241	0.199	0.19
Phenylalanine	63.679	57.277	57.775	66.457	50.462	79.295	54.775	53.413	63.864	66.692	110.481	67.647	58.521	61.019	60.311	55.883	58.704	53.794	52.462	49.476	86.4	38.428	22.428	50.054	62.575	47.292	77.457	50.167	33.631	48.014	53.622	55.503	50.258	40.266	32.135	52.686	70.762	65.169	49.207	58.608	48.331	55.139	53.747	50.809	78.444	72.947	56.954	61.935	86.075	72.614	43.625	70.065	75.5	42.245	50.543	37.774	27.933	40.607	29.478	36.655	47.387	48.268	37.594	43.922	41.396	39.87	43.416	45.856	30.008	46.727	49.875	43.532	49.218	53.86	48.155	45.3	34.906	43.146
Proline	7.966	7.405	7.181	6.624	7.46	7.507	5.876	6.854	7.647	7.238	6.797	7.193	7.231	6.778	5.437	7.763	6.506	6.18	6.128	5.331	5.198	3.924	2.326	5.906	6.217	5.169	8.734	5.604	2.986	5.335	5.751	6.353	9.324	7.658	6.583	10.557	10.764	10.778	10.117	10.161	9.485	9.723	9.329	9.095	12.159	11.643	10.483	10.458	12.719	11.163	8.013	10.647	11.844	6.965	10.091	6.64	6.534	6.576	5.259	7.562	8.541	7.858	6.538	7.54	6.869	6.869	6.584	7.293	5.327	7.02	7.534	6.843	7.661	8.231	7.931	7.452	6.541	6.661
Putrescine	0.344	0.284	0.378	0.386	0.302	0.567	0.306	0.24	0.323	0.374	0.276	0.348	0.337	0.255	0.227	0.342	0.249	0.189	0.191	0.276	0.141	0.126	0.098	0.2	0.287	0.171	0.432	0.223	0.105	0.239	0.247	0.274	20.679	14.547	11.313	14.03	24.049	28.6	59.941	16.163	26.826	22.506	18.938	26.431	39.469	28.995	23.78	18.297	37.514	23.628	14.324	21.717	26.082	9.316	25.459	10.177	45.775	8.618	7.265	10.323	19.288	13.469	8.432	29.419	8.524	9.154	11.57	11.754	7.826	13.017	13.518	11.48	9.302	10.906	25.981	10.894	6.02	7.433
S-Adenosylhomocysteine	0.271	0.292	0.201	0.224	0.262	0.266	0.17	0.193	0.268	0.285	0.249	0.277	0.22	0.256	0.247	0.294	0.206	0.185	0.198	0.15	0.172	0.137	0.105	0.188	0.198	0.152	0.306	0.14	0.159	0.169	0.174	0.191	25.173	20.686	15.496	23.816	25.343	23.604	30.392	26.375	21.934	22.6	22.15	23.901	28.713	25.589	28.98	23.131	36.106	33.187	20.6	30.673	28.462	14.348	25.811	11.033	14.001	15.2	12.108	11.501	13.318	13.304	9.894	10.747	15.467	13.347	9.475	14.675	8.791	13.714	14.351	11.944	18.003	22.1	15.721	15.823	12	16.146
S-Adenosylhomocysteine-d4	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.
S-Adenosylmethionine	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.
S-Adenosylmethionine-d3	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.
SDMA	0.024	0.016	0.018	0.017	0.017	0.022	0.017	0.016	0.022	0.019	0.022	0.021	0.018	0.016	0.015	0.02	0.019	0.017	0.016	0.016	0.017	0.013	0.008	0.016	0.017	0.016	0.02	0.017	0.005	0.016	0.018	0.018	0.047	0.037	0.033	0.044	0.061	0.051	0.051	0.05	0.053	0.057	0.047	0.051	0.07	0.055	0.066	0.064	0.068	0.062	0.047	0.056	0.064	0.03	0.038	0.028	0.044	0.036	0.021	0.025	0.041	0.043	0.031	0.038	0.03	0.032	0.032	0.03	0.022	0.038	0.033	0.029	0.028	0.041	0.033	0.034	0.022	0.03
Sarcosine	4.093	4.434	3.701	3.587	4.016	4.294	3.331	3.089	4.096	4.876	3.111	4.57	3.117	3.977	4.322	3.975	3.423	2.674	2.8	2.556	2.711	1.93	1.144	2.995	3.47	2.307	5.332	2.572	4.047	2.744	3.072	3.455	1.829	1.186	0.984	2.117	1.959	3.689	3.182	2.57	1.767	1.707	1.883	1.921	3.47	2.398	2.322	1.565	3.239	3.185	1.211	2.982	2.408	0.972	1.904	0.944	1.376	0.954	0.714	0.917	1.267	1.093	0.811	1.308	1.092	0.978	0.792	0.975	0.803	1.373	1.117	1.384	0.977	1.236	1.152	1.178	0.943	0.973
Serine	117.532	107.618	113.8	113.858	110.961	107.819	140.481	120.551	118.335	147.908	134.369	128.729	93.439	104.625	108.226	104.477	117.943	112.934	123.577	81.905	100.866	81.087	41.242	100.789	127.88	100.765	147.558	91.923	42.082	109.574	103.426	109.387	71.781	55.332	46.321	83.117	96.331	76.8	66.996	76.786	77.911	72.955	80.481	78.126	110.117	94.737	76.79	95.12	96.375	105.288	64.27	77.428	86.83	79.182	103.411	84.312	57.238	84.859	59.137	81.403	101.352	86.617	93.842	99.955	83.154	88.217	86.952	85.307	72.406	97.907	104.767	111.356	101.825	113.391	100.814	98.329	76.496	94.613
Spermidine	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	0.19	0.18	0.166	0.155	0.195	0.196	0.151	0.2	0.184	0.189	0.152	0.188	0.212	0.15	0.148	0.17	0.268	0.214	0.226	0.213	0.257	0.268	0.359	0.348	0.216	0.268	0.407	0.275	0.417	0.297	0.31	0.264	0.413	0.48	0.253	0.377	0.324	0.342	0.367	0.333	0.417	0.568	0.352	0.543	0.335	0.378
Spermine	0.015	0.186	0.023	0.029	0.011	0.012	0.02	0.01	0.022	0.028	0.024	0.008	0.028	0.01	0.011	0.022	0.018	0.01	0.008	0.011	0.008	0.005	0.016	0.004	0.012	0.007	0.021	0.012	0.011	0.012	0.008	0.018	0.007	0.004	0.004	0.003	0.003	0.006	0.003	0.004	0.011	0.004	0.008	0.006	0.005	0.006	0.003	0.002	0.005	0.004	0.006	0.013	0.004	0.003	0.004	0.005	0.005	0.003	0.003	0.003	0.005	0.004	0.004	0.005	0.002	0.004	0.006	0.003	0.003	0.004	0.002	0.001	0.003	0.003	0.003	0.003	0.002	0
Spermine-d8	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.
Threonine	24.738	21.663	21.391	22.278	22.099	29.597	23.318	19.426	24.235	26.261	18.024	28.646	18.096	21.102	21.913	20.773	22.332	19.138	23.987	17.186	13.898	13.11	6.706	17.933	22.871	17.403	32.088	16.247	11.124	17.037	18.334	20.822	22.606	18.19	15.735	24.353	36.955	26.115	21.06	25.365	26.414	23.86	24.898	23.498	37.299	31.821	24.971	26.651	32.54	38.127	18.306	27.792	29.024	18.674	24.077	18.032	10.89	18.997	12.47	17.081	25.313	20.876	18.224	18.737	17.378	19.334	19.119	18.618	13.568	22.853	25.152	26.665	22.171	29.541	23.426	21.473	18.034	20.778
Tryptophan	24.054	18.623	24.9	22.218	20.716	35.16	22.755	19.892	24.467	30.557	71.735	26.538	20.72	20.368	23.954	21.644	22.957	17.608	21.094	21.677	51.287	14.809	7.449	15.219	25.662	15.976	31.241	17.172	12.108	21.876	21.939	21.649	17.542	12.777	10.436	20.923	33.503	23.963	16.244	15.826	18.886	18.587	22.457	18.461	31.819	29.863	16.904	32.89	23.904	27.859	14.494	21.02	24.604	12.22	17.173	12.306	8.947	11.883	8.134	14.294	15.936	15.39	19.035	14.633	10.4	12.478	13.547	13.532	7.873	17.76	19.189	17.442	15.123	23.728	17.145	11.893	11.422	13.582
Valine	4.241	4.009	3.573	3.574	4.265	4.642	3.218	3.685	4.321	4.252	3.593	4.231	3.89	3.683	3.209	4.369	3.799	3.58	3.944	3.123	2.711	2.27	1.345	3.172	3.631	3.053	4.865	3.046	1.81	3.088	3.256	3.671	3.947	2.92	2.442	4.359	5.482	5.493	4.292	4.615	4.052	4.199	4.128	3.967	6.289	5.654	4.747	4.866	6.448	5.451	3.388	5.361	5.578	2.804	4.279	3.134	2.451	2.852	2.249	3.376	3.946	3.369	3.127	3.504	3.176	3.183	3.12	3.283	2.475	3.313	3.826	3.307	3.354	4.447	3.553	3.475	3.016	3.094
beta-Alanine	82.202	87.333	82.63	74.392	91.197	85.455	100.548	70.361	85.298	96.204	82.199	88.082	79.776	76.722	75.154	85.385	86.725	80.694	90.348	80.154	65.875	53.324	28.666	77.326	85.392	64.763	110.581	79.04	22.597	73.925	80.524	86.891	73.46	54.182	43.618	98.879	92.894	78.113	96.751	74.577	77.627	65.833	86.502	73.292	120.74	104.1	83.12	78.437	107.463	103.845	52.195	83.148	89.832	47.112	73.975	53.158	73.105	54.681	39.002	74.944	69.387	60.85	50.838	63.79	56.439	53.333	49.331	58.919	42.501	67.05	71.882	68.393	59.543	71.652	64.059	64.085	53.428	56.092
gamma-Aminobutyric acid	102.702	97.687	79.966	83.342	87.205	86.616	70.873	64.398	102.923	99.372	69.022	106.929	68.372	77.055	79.039	107.78	85.491	80.122	74.882	63.529	64.51	51.171	36.318	67.514	80.388	62.001	111.046	61.316	99.125	68.549	72.31	82.898	35.742	25.957	23.159	36.578	41.405	55.397	49.86	43.831	37.834	33.985	35.778	38.091	54.665	47.808	45.008	41.413	59.548	55.659	29.307	53.561	49.716	21.97	40.453	24.348	24.356	23.363	19.535	25.564	27.924	27.53	25.27	26.256	25.189	24.691	21.058	23.856	19.118	29.044	30.463	26.403	27.187	33.913	25.449	27.275	24.601	24.894
MS_METABOLITE_DATA_END
#METABOLITES
METABOLITES_START
metabolite_name	Expected RT	MS1_mz	MS2_mz
13C3,15N-Cysteine	8.5	396	180
13C4-Putrescine	8.29	363.1	270.1
13C4-Spermidine	8.02	555	193.2
6C13-Phenylalanine	8.23	307.3	261.3
Agmatine	3.88	266.2	131.1
Alanine	5.4	225.2	44.2
Alanine-d4	5.36	229.2	48
Arginine	3.75	310	217
Arginine-d4C13	2.62	450.3	210.3
Aspartic acid	4.53	269.2	116.2
beta-Alanine	5.4	225.1	90.1
Citrulline	4.35	311.2	113.1
Creatinine	0.7	114.1	44.1
Creatinine-d3	0.7	117.1	47.1
Cystathionine	7.98	493.3	400.1
Cystathionine-d4	7.96	497.3	404.1
Cysteine	8.51	392	177
Cysteinylglycine	8.21	449.3	374
Dopa	4.7	333.1	198.1
Dopamine	5.49	289.2	137.2
gamma-Aminobutyric acid	5.09	239	104.1
Glutamic acid	4.51	283.2	130.2
Glutamic acid-d3	4.61	286.2	133.3
Glutamine	3.87	282.2	130
Glutathione	7.93	443.3	221
Glutathione disulfide	4.19	748.4	655
Glutathione-(glycine-13C2,15N)	7.93	581.1	170
Glycine	4.01	211.2	75.9
Histidine	3.28	291.1	110.2
Homocysteine	8.68	406	236.9
Homocysteine-d4	7.81	410.2	241.1
Isoleucine	8.11	267.3	69
Kynurenine	8.08	344.2	146.2
Leucine	8.12	267.3	43
Lysine	8.11	417.2	324.2
Methionine	7.45	285.1	104.2
Methionine S-oxide	4.32	301.2	88.1
Methionine-d3	7.43	288.2	107
N-Acetylputrescine	3.66	266.1	173.4
N1-Acetylspermidine	7.93	458.1	230
N1-Acetylspermine	8.13	650.1	380.4
Ornithine	7.91	403.2	310.2
Phenylalanine	8.15	301.2	120.2
Proline	5.39	251.2	70.3
Putrescine	8.27	359.1	266.1
S-Adenosylhomocysteine	5.37	520.1	237.1
S-Adenosylhomocysteine-d4	5.29	524.1	240.1
S-Adenosylmethionine	3.8	534.2	150
S-Adenosylmethionine-d3	3.8	537.2	153
Sarcosine	4.59	225	90.1
SDMA	4.4	338.2	70.1
Serine	3.98	241.2	60
Spermidine	7.97	551.2	193.2
Spermine	9.26	743.3	193.2
Spermine-d8	9.25	751.3	193.2
Threonine	4.99	255.2	74.1
Tryptophan	8.14	340.2	188.2
Valine	7.6	253.2	72.2
METABOLITES_END
#END