#METABOLOMICS WORKBENCH Jung_DNLI_20250707_104749 DATATRACK_ID:6141 STUDY_ID:ST004059 ANALYSIS_ID:AN006718 PROJECT_ID:PR002548
VERSION             	1
CREATED_ON             	July 22, 2025, 11:13 am
#PROJECT
PR:PROJECT_TITLE                 	Lysosomal polyamine storage upon ATP13A2 loss impairs β-glucocerebrosidase via
PR:PROJECT_TITLE                 	altered lysosomal pH and electrostatic hydrolase-lipid interactions
PR:PROJECT_TYPE                  	Preclinical Mouse and cellular studies
PR:PROJECT_SUMMARY               	ATP13A2 is an endolysosomal polyamine transporter mutated in several
PR:PROJECT_SUMMARY               	neurodegenerative conditions involving lysosomal defects, including
PR:PROJECT_SUMMARY               	Parkinson’s disease (PD). While polyamines are polybasic and polycationic
PR:PROJECT_SUMMARY               	molecules that play pleiotropic cellular roles, their specific impact on
PR:PROJECT_SUMMARY               	lysosomal health is unknown. Here, we demonstrate lysosomal polyamine
PR:PROJECT_SUMMARY               	accumulation in ATP13A2 knockout (KO) cell lines. Primary polyamine storage
PR:PROJECT_SUMMARY               	caused secondary storage of lysosomal anionic phospholipid
PR:PROJECT_SUMMARY               	bis(monoacylglycero)phosphate (BMP) and age-dependent increase in the
PR:PROJECT_SUMMARY               	β-glucocerebrosidase (GCase) substrate, glucosylsphingosine, in Atp13a2 KO
PR:PROJECT_SUMMARY               	brains. Polyamine accumulation inhibited lysosomal GCase activity in cells and
PR:PROJECT_SUMMARY               	this was reversed by lysosome reacidification or BMP supplementation. A
PR:PROJECT_SUMMARY               	liposome-based GCase assay utilizing physiological substrates demonstrated
PR:PROJECT_SUMMARY               	dose-dependent inhibition of BMP-stimulated GCase activity by polyamines, in
PR:PROJECT_SUMMARY               	part via a pH-independent, electrostatics-based mechanism. Therefore, excess
PR:PROJECT_SUMMARY               	polyamine compromises lysosomes by disrupting pH and electrostatic interactions
PR:PROJECT_SUMMARY               	between GCase and BMP enabling efficient substrate hydrolysis, potentially
PR:PROJECT_SUMMARY               	clarifying their pathogenic mechanisms, and suggesting convergence on
PR:PROJECT_SUMMARY               	PD-relevant pathways.
PR:INSTITUTE                     	Denali Therapeutics
PR:LAST_NAME                     	Suh
PR:FIRST_NAME                    	Jung
PR:ADDRESS                       	161 Oyster Point Blvd, South San Francisco, California, 94080, USA
PR:EMAIL                         	suh@dnli.com
PR:PHONE                         	+1 06507973837
#STUDY
ST:STUDY_TITLE                   	Targeted Lipid and Metabolite Profiling in Brains of ATP13A2 Knockout Mice
ST:STUDY_SUMMARY                 	Comprehensive targeted profiling of lipids and metabolites was conducted in
ST:STUDY_SUMMARY                 	brain tissues from ATP13A2 knockout mice at 4.5 and 15 months of age to assess
ST:STUDY_SUMMARY                 	ATP13A2 deletion and its association with lysosomal dysfunction.
ST:INSTITUTE                     	Denali Therapeutics
ST:LAST_NAME                     	Suh
ST:FIRST_NAME                    	Jung
ST:ADDRESS                       	161 Oyster Point Blvd, South San Francisco, California, 94080, USA
ST:EMAIL                         	suh@dnli.com
ST:PHONE                         	+1 06507973837
#SUBJECT
SU:SUBJECT_TYPE                  	Mammal
SU:SUBJECT_SPECIES               	Mus musculus
SU:TAXONOMY_ID                   	10090
#SUBJECT_SAMPLE_FACTORS:         	SUBJECT(optional)[tab]SAMPLE[tab]FACTORS(NAME:VALUE pairs separated by |)[tab]Raw file names and additional sample data
SUBJECT_SAMPLE_FACTORS           	Pool_Cortex_001	HSA-000038800	genotype:WT | Sample source:brain	sex=NA; age=15; age_unit=month; region=Cortex; RAW_FILE_NAME(Raw Source Name.PITC)=20240607_MS_HEX-000817_PITC_Pos-20240607_MS_HEX-000817_Cortex_PITC_Pos_001.mzML; RAW_FILE_NAME(Raw Source Name.LP)=20240521_MS_HEX-000817_Lipid_Pos_001.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20240524_MS_HEX-000817_Lipid_Neg_001.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20240523_MS_HEX-000817_Met_Pos_001.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20240524_MS_HEX-000817_Met_Neg_001.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20240522_MS_HEX-000817_HALO_Pos_001.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20240528_MS_HEX-000817_GM_Neg_001.mzML
SUBJECT_SAMPLE_FACTORS           	Cortex_13	HSA-000038799	genotype:HOM KO ATP13A2 | Sample source:brain	sex=Male; age=15; age_unit=month; region=Cortex; RAW_FILE_NAME(Raw Source Name.PITC)=20240607_MS_HEX-000817_PITC_Pos-20240607_MS_HEX-000817_Cortex_PITC_Pos_002.mzML; RAW_FILE_NAME(Raw Source Name.LP)=20240521_MS_HEX-000817_Lipid_Pos_002.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20240524_MS_HEX-000817_Lipid_Neg_002.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20240523_MS_HEX-000817_Met_Pos_002.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20240524_MS_HEX-000817_Met_Neg_002.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20240522_MS_HEX-000817_HALO_Pos_002.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20240528_MS_HEX-000817_GM_Neg_002.mzML
SUBJECT_SAMPLE_FACTORS           	Cortex_08	HSA-000038794	genotype:HOM KO ATP13A2 | Sample source:brain	sex=Female; age=15; age_unit=month; region=Cortex; RAW_FILE_NAME(Raw Source Name.PITC)=20240607_MS_HEX-000817_PITC_Pos-20240607_MS_HEX-000817_Cortex_PITC_Pos_003.mzML; RAW_FILE_NAME(Raw Source Name.LP)=20240521_MS_HEX-000817_Lipid_Pos_003.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20240524_MS_HEX-000817_Lipid_Neg_003.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20240523_MS_HEX-000817_Met_Pos_003.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20240524_MS_HEX-000817_Met_Neg_003.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20240522_MS_HEX-000817_HALO_Pos_003.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20240528_MS_HEX-000817_GM_Neg_003.mzML
SUBJECT_SAMPLE_FACTORS           	Cortex_02	HSA-000038788	genotype:WT | Sample source:brain	sex=Male; age=15; age_unit=month; region=Cortex; RAW_FILE_NAME(Raw Source Name.PITC)=20240607_MS_HEX-000817_PITC_Pos-20240607_MS_HEX-000817_Cortex_PITC_Pos_004.mzML; RAW_FILE_NAME(Raw Source Name.LP)=20240521_MS_HEX-000817_Lipid_Pos_004.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20240524_MS_HEX-000817_Lipid_Neg_004.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20240523_MS_HEX-000817_Met_Pos_004.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20240524_MS_HEX-000817_Met_Neg_004.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20240522_MS_HEX-000817_HALO_Pos_004.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20240528_MS_HEX-000817_GM_Neg_004.mzML
SUBJECT_SAMPLE_FACTORS           	Cortex_11	HSA-000038797	genotype:HOM KO ATP13A2 | Sample source:brain	sex=Male; age=15; age_unit=month; region=Cortex; RAW_FILE_NAME(Raw Source Name.PITC)=20240607_MS_HEX-000817_PITC_Pos-20240607_MS_HEX-000817_Cortex_PITC_Pos_005.mzML; RAW_FILE_NAME(Raw Source Name.LP)=20240521_MS_HEX-000817_Lipid_Pos_005.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20240524_MS_HEX-000817_Lipid_Neg_005.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20240523_MS_HEX-000817_Met_Pos_005.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20240524_MS_HEX-000817_Met_Neg_005.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20240522_MS_HEX-000817_HALO_Pos_005.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20240528_MS_HEX-000817_GM_Neg_005.mzML
SUBJECT_SAMPLE_FACTORS           	Cortex_04	HSA-000038790	genotype:HOM KO ATP13A2 | Sample source:brain	sex=Male; age=15; age_unit=month; region=Cortex; RAW_FILE_NAME(Raw Source Name.PITC)=20240607_MS_HEX-000817_PITC_Pos-20240607_MS_HEX-000817_Cortex_PITC_Pos_006.mzML; RAW_FILE_NAME(Raw Source Name.LP)=20240521_MS_HEX-000817_Lipid_Pos_006.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20240524_MS_HEX-000817_Lipid_Neg_006.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20240523_MS_HEX-000817_Met_Pos_006.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20240524_MS_HEX-000817_Met_Neg_006.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20240522_MS_HEX-000817_HALO_Pos_006.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20240528_MS_HEX-000817_GM_Neg_006.mzML
SUBJECT_SAMPLE_FACTORS           	Cortex_12	HSA-000038798	genotype:WT | Sample source:brain	sex=Female; age=15; age_unit=month; region=Cortex; RAW_FILE_NAME(Raw Source Name.PITC)=20240607_MS_HEX-000817_PITC_Pos-20240607_MS_HEX-000817_Cortex_PITC_Pos_007.mzML; RAW_FILE_NAME(Raw Source Name.LP)=20240521_MS_HEX-000817_Lipid_Pos_007.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20240524_MS_HEX-000817_Lipid_Neg_007.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20240523_MS_HEX-000817_Met_Pos_007.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20240524_MS_HEX-000817_Met_Neg_007.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20240522_MS_HEX-000817_HALO_Pos_007.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20240528_MS_HEX-000817_GM_Neg_007.mzML
SUBJECT_SAMPLE_FACTORS           	Cortex_09	HSA-000038795	genotype:NA | Sample source:brain	sex=Male; age=15; age_unit=month; region=Cortex; RAW_FILE_NAME(Raw Source Name.PITC)=20240607_MS_HEX-000817_PITC_Pos-20240607_MS_HEX-000817_Cortex_PITC_Pos_008.mzML; RAW_FILE_NAME(Raw Source Name.LP)=20240521_MS_HEX-000817_Lipid_Pos_008.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20240524_MS_HEX-000817_Lipid_Neg_008.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20240523_MS_HEX-000817_Met_Pos_008.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20240524_MS_HEX-000817_Met_Neg_008.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20240522_MS_HEX-000817_HALO_Pos_008.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20240528_MS_HEX-000817_GM_Neg_008.mzML
SUBJECT_SAMPLE_FACTORS           	Pool_Cortex_002	HSA-000039091	genotype:HOM KO ATP13A2 | Sample source:brain	sex=NA; age=15; age_unit=month; region=Cortex; RAW_FILE_NAME(Raw Source Name.PITC)=20240607_MS_HEX-000817_PITC_Pos-20240607_MS_HEX-000817_Cortex_PITC_Pos_009.mzML; RAW_FILE_NAME(Raw Source Name.LP)=20240521_MS_HEX-000817_Lipid_Pos_009.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20240524_MS_HEX-000817_Lipid_Neg_009.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20240523_MS_HEX-000817_Met_Pos_009.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20240524_MS_HEX-000817_Met_Neg_009.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20240522_MS_HEX-000817_HALO_Pos_009.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20240528_MS_HEX-000817_GM_Neg_009.mzML
SUBJECT_SAMPLE_FACTORS           	Cortex_10	HSA-000038796	genotype:WT | Sample source:brain	sex=Female; age=15; age_unit=month; region=Cortex; RAW_FILE_NAME(Raw Source Name.PITC)=20240607_MS_HEX-000817_PITC_Pos-20240607_MS_HEX-000817_Cortex_PITC_Pos_010.mzML; RAW_FILE_NAME(Raw Source Name.LP)=20240521_MS_HEX-000817_Lipid_Pos_010.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20240524_MS_HEX-000817_Lipid_Neg_010.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20240523_MS_HEX-000817_Met_Pos_010.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20240524_MS_HEX-000817_Met_Neg_010.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20240522_MS_HEX-000817_HALO_Pos_010.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20240528_MS_HEX-000817_GM_Neg_010.mzML
SUBJECT_SAMPLE_FACTORS           	Cortex_05	HSA-000038791	genotype:WT | Sample source:brain	sex=Female; age=15; age_unit=month; region=Cortex; RAW_FILE_NAME(Raw Source Name.PITC)=20240607_MS_HEX-000817_PITC_Pos-20240607_MS_HEX-000817_Cortex_PITC_Pos_011.mzML; RAW_FILE_NAME(Raw Source Name.LP)=20240521_MS_HEX-000817_Lipid_Pos_011.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20240524_MS_HEX-000817_Lipid_Neg_011.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20240523_MS_HEX-000817_Met_Pos_011.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20240524_MS_HEX-000817_Met_Neg_011.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20240522_MS_HEX-000817_HALO_Pos_011.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20240528_MS_HEX-000817_GM_Neg_011.mzML
SUBJECT_SAMPLE_FACTORS           	Cortex_01	HSA-000038787	genotype:HOM KO ATP13A2 | Sample source:brain	sex=Female; age=15; age_unit=month; region=Cortex; RAW_FILE_NAME(Raw Source Name.PITC)=20240607_MS_HEX-000817_PITC_Pos-20240607_MS_HEX-000817_Cortex_PITC_Pos_012.mzML; RAW_FILE_NAME(Raw Source Name.LP)=20240521_MS_HEX-000817_Lipid_Pos_012.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20240524_MS_HEX-000817_Lipid_Neg_012.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20240523_MS_HEX-000817_Met_Pos_012.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20240524_MS_HEX-000817_Met_Neg_012.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20240522_MS_HEX-000817_HALO_Pos_012.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20240528_MS_HEX-000817_GM_Neg_012.mzML
SUBJECT_SAMPLE_FACTORS           	Cortex_06	HSA-000038792	genotype:WT | Sample source:brain	sex=Male; age=15; age_unit=month; region=Cortex; RAW_FILE_NAME(Raw Source Name.PITC)=20240607_MS_HEX-000817_PITC_Pos-20240607_MS_HEX-000817_Cortex_PITC_Pos_013.mzML; RAW_FILE_NAME(Raw Source Name.LP)=20240521_MS_HEX-000817_Lipid_Pos_013.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20240524_MS_HEX-000817_Lipid_Neg_013.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20240523_MS_HEX-000817_Met_Pos_013.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20240524_MS_HEX-000817_Met_Neg_013.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20240522_MS_HEX-000817_HALO_Pos_013.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20240528_MS_HEX-000817_GM_Neg_013.mzML
SUBJECT_SAMPLE_FACTORS           	Cortex_07	HSA-000038793	genotype:WT | Sample source:brain	sex=Male; age=15; age_unit=month; region=Cortex; RAW_FILE_NAME(Raw Source Name.PITC)=20240607_MS_HEX-000817_PITC_Pos-20240607_MS_HEX-000817_Cortex_PITC_Pos_014.mzML; RAW_FILE_NAME(Raw Source Name.LP)=20240521_MS_HEX-000817_Lipid_Pos_014.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20240524_MS_HEX-000817_Lipid_Neg_014.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20240523_MS_HEX-000817_Met_Pos_014.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20240524_MS_HEX-000817_Met_Neg_014.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20240522_MS_HEX-000817_HALO_Pos_014.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20240528_MS_HEX-000817_GM_Neg_014.mzML
SUBJECT_SAMPLE_FACTORS           	Cortex_03	HSA-000038789	genotype:NA | Sample source:brain	sex=Female; age=15; age_unit=month; region=Cortex; RAW_FILE_NAME(Raw Source Name.PITC)=20240607_MS_HEX-000817_PITC_Pos-20240607_MS_HEX-000817_Cortex_PITC_Pos_015.mzML; RAW_FILE_NAME(Raw Source Name.LP)=20240521_MS_HEX-000817_Lipid_Pos_015.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20240524_MS_HEX-000817_Lipid_Neg_015.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20240523_MS_HEX-000817_Met_Pos_015.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20240524_MS_HEX-000817_Met_Neg_015.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20240522_MS_HEX-000817_HALO_Pos_015.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20240528_MS_HEX-000817_GM_Neg_015.mzML
SUBJECT_SAMPLE_FACTORS           	Pool_Cortex_003	HSA-000039092	genotype:NA | Sample source:brain	sex=NA; age=15; age_unit=month; region=Cortex; RAW_FILE_NAME(Raw Source Name.PITC)=20240607_MS_HEX-000817_PITC_Pos-20240607_MS_HEX-000817_Cortex_PITC_Pos_016.mzML; RAW_FILE_NAME(Raw Source Name.LP)=20240521_MS_HEX-000817_Lipid_Pos_016.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20240524_MS_HEX-000817_Lipid_Neg_016.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20240523_MS_HEX-000817_Met_Pos_016.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20240524_MS_HEX-000817_Met_Neg_016.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20240522_MS_HEX-000817_HALO_Pos_016.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20240528_MS_HEX-000817_GM_Neg_016.mzML
SUBJECT_SAMPLE_FACTORS           	Pool_Hippo_001	HSA-000038814	genotype:WT | Sample source:brain	sex=NA; age=15; age_unit=month; region=Hippocampus; RAW_FILE_NAME(Raw Source Name.PITC)=20240607_MS_HEX-000817_PITC_Pos-20240607_MS_HEX-000817_HippC_PITC_Pos_002; RAW_FILE_NAME(Raw Source Name.LP)=20240521_MS_HEX-000817_Lipid_Pos_017.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20240524_MS_HEX-000817_Lipid_Neg_017.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20240523_MS_HEX-000817_Met_Pos_017.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20240524_MS_HEX-000817_Met_Neg_017.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20240522_MS_HEX-000817_HALO_Pos_017.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20240528_MS_HEX-000817_GM_Neg_017.mzML
SUBJECT_SAMPLE_FACTORS           	Hipp_13	HSA-000038813	genotype:WT | Sample source:brain	sex=Male; age=15; age_unit=month; region=Hippocampus; RAW_FILE_NAME(Raw Source Name.PITC)=20240607_MS_HEX-000817_PITC_Pos-20240607_MS_HEX-000817_HippC_PITC_Pos_003; RAW_FILE_NAME(Raw Source Name.LP)=20240521_MS_HEX-000817_Lipid_Pos_018.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20240524_MS_HEX-000817_Lipid_Neg_018.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20240523_MS_HEX-000817_Met_Pos_018.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20240524_MS_HEX-000817_Met_Neg_018.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20240522_MS_HEX-000817_HALO_Pos_018.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20240528_MS_HEX-000817_GM_Neg_018.mzML
SUBJECT_SAMPLE_FACTORS           	Hipp_11	HSA-000038811	genotype:HOM KO ATP13A2 | Sample source:brain	sex=Male; age=15; age_unit=month; region=Hippocampus; RAW_FILE_NAME(Raw Source Name.PITC)=20240607_MS_HEX-000817_PITC_Pos-20240607_MS_HEX-000817_HippC_PITC_Pos_004; RAW_FILE_NAME(Raw Source Name.LP)=20240521_MS_HEX-000817_Lipid_Pos_019.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20240524_MS_HEX-000817_Lipid_Neg_019.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20240523_MS_HEX-000817_Met_Pos_019.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20240524_MS_HEX-000817_Met_Neg_019.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20240522_MS_HEX-000817_HALO_Pos_019.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20240528_MS_HEX-000817_GM_Neg_019.mzML
SUBJECT_SAMPLE_FACTORS           	Hipp_04	HSA-000038804	genotype:WT | Sample source:brain	sex=Male; age=15; age_unit=month; region=Hippocampus; RAW_FILE_NAME(Raw Source Name.PITC)=20240607_MS_HEX-000817_PITC_Pos-20240607_MS_HEX-000817_HippC_PITC_Pos_005; RAW_FILE_NAME(Raw Source Name.LP)=20240521_MS_HEX-000817_Lipid_Pos_020.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20240524_MS_HEX-000817_Lipid_Neg_020.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20240523_MS_HEX-000817_Met_Pos_020.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20240524_MS_HEX-000817_Met_Neg_020.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20240522_MS_HEX-000817_HALO_Pos_020.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20240528_MS_HEX-000817_GM_Neg_020.mzML
SUBJECT_SAMPLE_FACTORS           	Hipp_05	HSA-000038805	genotype:WT | Sample source:brain	sex=Female; age=15; age_unit=month; region=Hippocampus; RAW_FILE_NAME(Raw Source Name.PITC)=20240607_MS_HEX-000817_PITC_Pos-20240607_MS_HEX-000817_HippC_PITC_Pos_006; RAW_FILE_NAME(Raw Source Name.LP)=20240521_MS_HEX-000817_Lipid_Pos_021.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20240524_MS_HEX-000817_Lipid_Neg_021.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20240523_MS_HEX-000817_Met_Pos_021.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20240524_MS_HEX-000817_Met_Neg_021.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20240522_MS_HEX-000817_HALO_Pos_021.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20240528_MS_HEX-000817_GM_Neg_021.mzML
SUBJECT_SAMPLE_FACTORS           	Hipp_03	HSA-000038803	genotype:HOM KO ATP13A2 | Sample source:brain	sex=Female; age=15; age_unit=month; region=Hippocampus; RAW_FILE_NAME(Raw Source Name.PITC)=20240607_MS_HEX-000817_PITC_Pos-20240607_MS_HEX-000817_HippC_PITC_Pos_007; RAW_FILE_NAME(Raw Source Name.LP)=20240521_MS_HEX-000817_Lipid_Pos_022.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20240524_MS_HEX-000817_Lipid_Neg_022.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20240523_MS_HEX-000817_Met_Pos_022.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20240524_MS_HEX-000817_Met_Neg_022.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20240522_MS_HEX-000817_HALO_Pos_022.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20240528_MS_HEX-000817_GM_Neg_022.mzML
SUBJECT_SAMPLE_FACTORS           	Hipp_02	HSA-000038802	genotype:WT | Sample source:brain	sex=Male; age=15; age_unit=month; region=Hippocampus; RAW_FILE_NAME(Raw Source Name.PITC)=20240607_MS_HEX-000817_PITC_Pos-20240607_MS_HEX-000817_HippC_PITC_Pos_008; RAW_FILE_NAME(Raw Source Name.LP)=20240521_MS_HEX-000817_Lipid_Pos_023.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20240524_MS_HEX-000817_Lipid_Neg_023.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20240523_MS_HEX-000817_Met_Pos_023.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20240524_MS_HEX-000817_Met_Neg_023.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20240522_MS_HEX-000817_HALO_Pos_023.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20240528_MS_HEX-000817_GM_Neg_023.mzML
SUBJECT_SAMPLE_FACTORS           	Hipp_07	HSA-000038807	genotype:NA | Sample source:brain	sex=Male; age=15; age_unit=month; region=Hippocampus; RAW_FILE_NAME(Raw Source Name.PITC)=20240607_MS_HEX-000817_PITC_Pos-20240607_MS_HEX-000817_HippC_PITC_Pos_009; RAW_FILE_NAME(Raw Source Name.LP)=20240521_MS_HEX-000817_Lipid_Pos_024.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20240524_MS_HEX-000817_Lipid_Neg_024.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20240523_MS_HEX-000817_Met_Pos_024.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20240524_MS_HEX-000817_Met_Neg_024.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20240522_MS_HEX-000817_HALO_Pos_024.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20240528_MS_HEX-000817_GM_Neg_024.mzML
SUBJECT_SAMPLE_FACTORS           	Pool_Hippo_002	HSA-000039093	genotype:WT | Sample source:brain	sex=NA; age=15; age_unit=month; region=Hippocampus; RAW_FILE_NAME(Raw Source Name.PITC)=20240607_MS_HEX-000817_PITC_Pos-20240607_MS_HEX-000817_HippC_PITC_Pos_010; RAW_FILE_NAME(Raw Source Name.LP)=20240521_MS_HEX-000817_Lipid_Pos_025.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20240524_MS_HEX-000817_Lipid_Neg_025.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20240523_MS_HEX-000817_Met_Pos_025.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20240524_MS_HEX-000817_Met_Neg_025.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20240522_MS_HEX-000817_HALO_Pos_025.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20240528_MS_HEX-000817_GM_Neg_025.mzML
SUBJECT_SAMPLE_FACTORS           	Hipp_09	HSA-000038809	genotype:HOM KO ATP13A2 | Sample source:brain	sex=Male; age=15; age_unit=month; region=Hippocampus; RAW_FILE_NAME(Raw Source Name.PITC)=20240607_MS_HEX-000817_PITC_Pos-20240607_MS_HEX-000817_HippC_PITC_Pos_011; RAW_FILE_NAME(Raw Source Name.LP)=20240521_MS_HEX-000817_Lipid_Pos_026.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20240524_MS_HEX-000817_Lipid_Neg_026.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20240523_MS_HEX-000817_Met_Pos_026.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20240524_MS_HEX-000817_Met_Neg_026.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20240522_MS_HEX-000817_HALO_Pos_026.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20240528_MS_HEX-000817_GM_Neg_026.mzML
SUBJECT_SAMPLE_FACTORS           	Hipp_12	HSA-000038812	genotype:HOM KO ATP13A2 | Sample source:brain	sex=Female; age=15; age_unit=month; region=Hippocampus; RAW_FILE_NAME(Raw Source Name.PITC)=20240607_MS_HEX-000817_PITC_Pos-20240607_MS_HEX-000817_HippC_PITC_Pos_012; RAW_FILE_NAME(Raw Source Name.LP)=20240521_MS_HEX-000817_Lipid_Pos_027.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20240524_MS_HEX-000817_Lipid_Neg_027.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20240523_MS_HEX-000817_Met_Pos_027.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20240524_MS_HEX-000817_Met_Neg_027.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20240522_MS_HEX-000817_HALO_Pos_027.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20240528_MS_HEX-000817_GM_Neg_027.mzML
SUBJECT_SAMPLE_FACTORS           	Hipp_06	HSA-000038806	genotype:WT | Sample source:brain	sex=Male; age=15; age_unit=month; region=Hippocampus; RAW_FILE_NAME(Raw Source Name.PITC)=20240607_MS_HEX-000817_PITC_Pos-20240607_MS_HEX-000817_HippC_PITC_Pos_013; RAW_FILE_NAME(Raw Source Name.LP)=20240521_MS_HEX-000817_Lipid_Pos_028.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20240524_MS_HEX-000817_Lipid_Neg_028.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20240523_MS_HEX-000817_Met_Pos_028.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20240524_MS_HEX-000817_Met_Neg_028.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20240522_MS_HEX-000817_HALO_Pos_028.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20240528_MS_HEX-000817_GM_Neg_028.mzML
SUBJECT_SAMPLE_FACTORS           	Hipp_01	HSA-000038801	genotype:HOM KO ATP13A2 | Sample source:brain	sex=Female; age=15; age_unit=month; region=Hippocampus; RAW_FILE_NAME(Raw Source Name.PITC)=20240607_MS_HEX-000817_PITC_Pos-20240607_MS_HEX-000817_HippC_PITC_Pos_014; RAW_FILE_NAME(Raw Source Name.LP)=20240521_MS_HEX-000817_Lipid_Pos_029.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20240524_MS_HEX-000817_Lipid_Neg_029.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20240523_MS_HEX-000817_Met_Pos_029.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20240524_MS_HEX-000817_Met_Neg_029.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20240522_MS_HEX-000817_HALO_Pos_029.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20240528_MS_HEX-000817_GM_Neg_029.mzML
SUBJECT_SAMPLE_FACTORS           	Hipp_10	HSA-000038810	genotype:HOM KO ATP13A2 | Sample source:brain	sex=Female; age=15; age_unit=month; region=Hippocampus; RAW_FILE_NAME(Raw Source Name.PITC)=20240607_MS_HEX-000817_PITC_Pos-20240607_MS_HEX-000817_HippC_PITC_Pos_015; RAW_FILE_NAME(Raw Source Name.LP)=20240521_MS_HEX-000817_Lipid_Pos_030.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20240524_MS_HEX-000817_Lipid_Neg_030.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20240523_MS_HEX-000817_Met_Pos_030.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20240524_MS_HEX-000817_Met_Neg_030.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20240522_MS_HEX-000817_HALO_Pos_030.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20240528_MS_HEX-000817_GM_Neg_030.mzML
SUBJECT_SAMPLE_FACTORS           	Hipp_08	HSA-000038808	genotype:NA | Sample source:brain	sex=Female; age=15; age_unit=month; region=Hippocampus; RAW_FILE_NAME(Raw Source Name.PITC)=20240607_MS_HEX-000817_PITC_Pos-20240607_MS_HEX-000817_HippC_PITC_Pos_016; RAW_FILE_NAME(Raw Source Name.LP)=20240521_MS_HEX-000817_Lipid_Pos_031.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20240524_MS_HEX-000817_Lipid_Neg_031.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20240523_MS_HEX-000817_Met_Pos_031.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20240524_MS_HEX-000817_Met_Neg_031.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20240522_MS_HEX-000817_HALO_Pos_031.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20240528_MS_HEX-000817_GM_Neg_031.mzML
SUBJECT_SAMPLE_FACTORS           	Pool_Hippo_003	HSA-000039094	genotype:NA | Sample source:brain	sex=NA; age=15; age_unit=month; region=Hippocampus; RAW_FILE_NAME(Raw Source Name.PITC)=20240607_MS_HEX-000817_PITC_Pos-20240607_MS_HEX-000817_HippC_PITC_Pos_017; RAW_FILE_NAME(Raw Source Name.LP)=20240521_MS_HEX-000817_Lipid_Pos_032.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20240524_MS_HEX-000817_Lipid_Neg_032.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20240523_MS_HEX-000817_Met_Pos_032.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20240524_MS_HEX-000817_Met_Neg_032.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20240522_MS_HEX-000817_HALO_Pos_032.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20240528_MS_HEX-000817_GM_Neg_032.mzML
SUBJECT_SAMPLE_FACTORS           	Cortex_pool-1	HSA-000034484	genotype:NA | Sample source:brain	sex=NA; age=4.5; age_unit=month; region=Cortex; RAW_FILE_NAME(Raw Source Name.PITC)=20231013_MS_HEX-000681_PITC_Pos-20231013_MS_HEX-000681_Cortex_PITC_Pos_001.mzML; RAW_FILE_NAME(Raw Source Name.LP)=20231006_MS_HEX-000681_Lipid_Pos-20231006_MS_HEX-000681_Cortex_Lipid_Pos_001.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20231008_MS_HEX-000681_Lipid_Neg-20231008_MS_HEX-000681_Cortex_Lipid_Neg_001.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20231007_MS_HEX-000681_Met_Pos-20231007_MS_HEX-000681_Cortex_Met_Pos_001.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20231008_MS_HEX-000681_Met_Neg-20231008_MS_HEX-000681_Cortex_Met_Neg_001.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20231007_MS_HEX-000681_HALO_Pos-20231007_MS_HEX-000681_Cortex_HALO_Pos_001.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20231010_MS_HEX-000681_GM_Neg-20231010_MS_HEX-000681_Cortex_GM_Neg_001.mzML
SUBJECT_SAMPLE_FACTORS           	Cortex_09	HSA-000034472	genotype:HET KO ATP13A2 | Sample source:brain	sex=Male; age=4.5; age_unit=month; region=Cortex; RAW_FILE_NAME(Raw Source Name.PITC)=20231013_MS_HEX-000681_PITC_Pos-20231013_MS_HEX-000681_Cortex_PITC_Pos_002.mzML; RAW_FILE_NAME(Raw Source Name.LP)=20231006_MS_HEX-000681_Lipid_Pos-20231006_MS_HEX-000681_Cortex_Lipid_Pos_002.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20231008_MS_HEX-000681_Lipid_Neg-20231008_MS_HEX-000681_Cortex_Lipid_Neg_002.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20231007_MS_HEX-000681_Met_Pos-20231007_MS_HEX-000681_Cortex_Met_Pos_002.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20231008_MS_HEX-000681_Met_Neg-20231008_MS_HEX-000681_Cortex_Met_Neg_002.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20231007_MS_HEX-000681_HALO_Pos-20231007_MS_HEX-000681_Cortex_HALO_Pos_002.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20231010_MS_HEX-000681_GM_Neg-20231010_MS_HEX-000681_Cortex_GM_Neg_002.mzML
SUBJECT_SAMPLE_FACTORS           	Cortex_07	HSA-000034470	genotype:WT | Sample source:brain	sex=Male; age=4.5; age_unit=month; region=Cortex; RAW_FILE_NAME(Raw Source Name.PITC)=20231013_MS_HEX-000681_PITC_Pos-20231013_MS_HEX-000681_Cortex_PITC_Pos_003.mzML; RAW_FILE_NAME(Raw Source Name.LP)=20231006_MS_HEX-000681_Lipid_Pos-20231006_MS_HEX-000681_Cortex_Lipid_Pos_003.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20231008_MS_HEX-000681_Lipid_Neg-20231008_MS_HEX-000681_Cortex_Lipid_Neg_003.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20231007_MS_HEX-000681_Met_Pos-20231007_MS_HEX-000681_Cortex_Met_Pos_003.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20231008_MS_HEX-000681_Met_Neg-20231008_MS_HEX-000681_Cortex_Met_Neg_003.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20231007_MS_HEX-000681_HALO_Pos-20231007_MS_HEX-000681_Cortex_HALO_Pos_003.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20231010_MS_HEX-000681_GM_Neg-20231010_MS_HEX-000681_Cortex_GM_Neg_003.mzML
SUBJECT_SAMPLE_FACTORS           	Cortex_16	HSA-000034479	genotype:WT | Sample source:brain	sex=Female; age=4.5; age_unit=month; region=Cortex; RAW_FILE_NAME(Raw Source Name.PITC)=20231013_MS_HEX-000681_PITC_Pos-20231013_MS_HEX-000681_Cortex_PITC_Pos_004.mzML; RAW_FILE_NAME(Raw Source Name.LP)=20231006_MS_HEX-000681_Lipid_Pos-20231006_MS_HEX-000681_Cortex_Lipid_Pos_004.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20231008_MS_HEX-000681_Lipid_Neg-20231008_MS_HEX-000681_Cortex_Lipid_Neg_004.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20231007_MS_HEX-000681_Met_Pos-20231007_MS_HEX-000681_Cortex_Met_Pos_004.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20231008_MS_HEX-000681_Met_Neg-20231008_MS_HEX-000681_Cortex_Met_Neg_004.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20231007_MS_HEX-000681_HALO_Pos-20231007_MS_HEX-000681_Cortex_HALO_Pos_004.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20231010_MS_HEX-000681_GM_Neg-20231010_MS_HEX-000681_Cortex_GM_Neg_004.mzML
SUBJECT_SAMPLE_FACTORS           	Cortex_04	HSA-000034467	genotype:WT | Sample source:brain	sex=Female; age=4.5; age_unit=month; region=Cortex; RAW_FILE_NAME(Raw Source Name.PITC)=20231013_MS_HEX-000681_PITC_Pos-20231013_MS_HEX-000681_Cortex_PITC_Pos_005.mzML; RAW_FILE_NAME(Raw Source Name.LP)=20231006_MS_HEX-000681_Lipid_Pos-20231006_MS_HEX-000681_Cortex_Lipid_Pos_005.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20231008_MS_HEX-000681_Lipid_Neg-20231008_MS_HEX-000681_Cortex_Lipid_Neg_005.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20231007_MS_HEX-000681_Met_Pos-20231007_MS_HEX-000681_Cortex_Met_Pos_005.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20231008_MS_HEX-000681_Met_Neg-20231008_MS_HEX-000681_Cortex_Met_Neg_005.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20231007_MS_HEX-000681_HALO_Pos-20231007_MS_HEX-000681_Cortex_HALO_Pos_005.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20231010_MS_HEX-000681_GM_Neg-20231010_MS_HEX-000681_Cortex_GM_Neg_005.mzML
SUBJECT_SAMPLE_FACTORS           	Cortex_20	HSA-000034483	genotype:HOM KO ATP13A2 | Sample source:brain	sex=Female; age=4.5; age_unit=month; region=Cortex; RAW_FILE_NAME(Raw Source Name.PITC)=20231013_MS_HEX-000681_PITC_Pos-20231013_MS_HEX-000681_Cortex_PITC_Pos_006.mzML; RAW_FILE_NAME(Raw Source Name.LP)=20231006_MS_HEX-000681_Lipid_Pos-20231006_MS_HEX-000681_Cortex_Lipid_Pos_006.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20231008_MS_HEX-000681_Lipid_Neg-20231008_MS_HEX-000681_Cortex_Lipid_Neg_006.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20231007_MS_HEX-000681_Met_Pos-20231007_MS_HEX-000681_Cortex_Met_Pos_006.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20231008_MS_HEX-000681_Met_Neg-20231008_MS_HEX-000681_Cortex_Met_Neg_006.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20231007_MS_HEX-000681_HALO_Pos-20231007_MS_HEX-000681_Cortex_HALO_Pos_006.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20231010_MS_HEX-000681_GM_Neg-20231010_MS_HEX-000681_Cortex_GM_Neg_006.mzML
SUBJECT_SAMPLE_FACTORS           	Cortex_18	HSA-000034481	genotype:HET KO ATP13A2 | Sample source:brain	sex=Female; age=4.5; age_unit=month; region=Cortex; RAW_FILE_NAME(Raw Source Name.PITC)=20231013_MS_HEX-000681_PITC_Pos-20231013_MS_HEX-000681_Cortex_PITC_Pos_007.mzML; RAW_FILE_NAME(Raw Source Name.LP)=20231006_MS_HEX-000681_Lipid_Pos-20231006_MS_HEX-000681_Cortex_Lipid_Pos_007.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20231008_MS_HEX-000681_Lipid_Neg-20231008_MS_HEX-000681_Cortex_Lipid_Neg_007.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20231007_MS_HEX-000681_Met_Pos-20231007_MS_HEX-000681_Cortex_Met_Pos_007.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20231008_MS_HEX-000681_Met_Neg-20231008_MS_HEX-000681_Cortex_Met_Neg_007.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20231007_MS_HEX-000681_HALO_Pos-20231007_MS_HEX-000681_Cortex_HALO_Pos_007.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20231010_MS_HEX-000681_GM_Neg-20231010_MS_HEX-000681_Cortex_GM_Neg_007.mzML
SUBJECT_SAMPLE_FACTORS           	Cortex_15	HSA-000034478	genotype:HET KO ATP13A2 | Sample source:brain	sex=Male; age=4.5; age_unit=month; region=Cortex; RAW_FILE_NAME(Raw Source Name.PITC)=20231013_MS_HEX-000681_PITC_Pos-20231013_MS_HEX-000681_Cortex_PITC_Pos_008.mzML; RAW_FILE_NAME(Raw Source Name.LP)=20231006_MS_HEX-000681_Lipid_Pos-20231006_MS_HEX-000681_Cortex_Lipid_Pos_008.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20231008_MS_HEX-000681_Lipid_Neg-20231008_MS_HEX-000681_Cortex_Lipid_Neg_008.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20231007_MS_HEX-000681_Met_Pos-20231007_MS_HEX-000681_Cortex_Met_Pos_008.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20231008_MS_HEX-000681_Met_Neg-20231008_MS_HEX-000681_Cortex_Met_Neg_008.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20231007_MS_HEX-000681_HALO_Pos-20231007_MS_HEX-000681_Cortex_HALO_Pos_008.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20231010_MS_HEX-000681_GM_Neg-20231010_MS_HEX-000681_Cortex_GM_Neg_008.mzML
SUBJECT_SAMPLE_FACTORS           	Cortex_08	HSA-000034471	genotype:HOM KO ATP13A2 | Sample source:brain	sex=Female; age=4.5; age_unit=month; region=Cortex; RAW_FILE_NAME(Raw Source Name.PITC)=20231013_MS_HEX-000681_PITC_Pos-20231013_MS_HEX-000681_Cortex_PITC_Pos_009.mzML; RAW_FILE_NAME(Raw Source Name.LP)=20231006_MS_HEX-000681_Lipid_Pos-20231006_MS_HEX-000681_Cortex_Lipid_Pos_009.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20231008_MS_HEX-000681_Lipid_Neg-20231008_MS_HEX-000681_Cortex_Lipid_Neg_009.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20231007_MS_HEX-000681_Met_Pos-20231007_MS_HEX-000681_Cortex_Met_Pos_009.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20231008_MS_HEX-000681_Met_Neg-20231008_MS_HEX-000681_Cortex_Met_Neg_009.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20231007_MS_HEX-000681_HALO_Pos-20231007_MS_HEX-000681_Cortex_HALO_Pos_009.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20231010_MS_HEX-000681_GM_Neg-20231010_MS_HEX-000681_Cortex_GM_Neg_009.mzML
SUBJECT_SAMPLE_FACTORS           	Cortex_03	HSA-000034466	genotype:HET KO ATP13A2 | Sample source:brain	sex=Male; age=4.5; age_unit=month; region=Cortex; RAW_FILE_NAME(Raw Source Name.PITC)=20231013_MS_HEX-000681_PITC_Pos-20231013_MS_HEX-000681_Cortex_PITC_Pos_010.mzML; RAW_FILE_NAME(Raw Source Name.LP)=20231006_MS_HEX-000681_Lipid_Pos-20231006_MS_HEX-000681_Cortex_Lipid_Pos_010.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20231008_MS_HEX-000681_Lipid_Neg-20231008_MS_HEX-000681_Cortex_Lipid_Neg_010.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20231007_MS_HEX-000681_Met_Pos-20231007_MS_HEX-000681_Cortex_Met_Pos_010.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20231008_MS_HEX-000681_Met_Neg-20231008_MS_HEX-000681_Cortex_Met_Neg_010.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20231007_MS_HEX-000681_HALO_Pos-20231007_MS_HEX-000681_Cortex_HALO_Pos_010.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20231010_MS_HEX-000681_GM_Neg-20231010_MS_HEX-000681_Cortex_GM_Neg_010.mzML
SUBJECT_SAMPLE_FACTORS           	Cortex_14	HSA-000034477	genotype:HOM KO ATP13A2 | Sample source:brain	sex=Female; age=4.5; age_unit=month; region=Cortex; RAW_FILE_NAME(Raw Source Name.PITC)=20231013_MS_HEX-000681_PITC_Pos-20231013_MS_HEX-000681_Cortex_PITC_Pos_011.mzML; RAW_FILE_NAME(Raw Source Name.LP)=20231006_MS_HEX-000681_Lipid_Pos-20231006_MS_HEX-000681_Cortex_Lipid_Pos_011.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20231008_MS_HEX-000681_Lipid_Neg-20231008_MS_HEX-000681_Cortex_Lipid_Neg_011.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20231007_MS_HEX-000681_Met_Pos-20231007_MS_HEX-000681_Cortex_Met_Pos_011.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20231008_MS_HEX-000681_Met_Neg-20231008_MS_HEX-000681_Cortex_Met_Neg_011.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20231007_MS_HEX-000681_HALO_Pos-20231007_MS_HEX-000681_Cortex_HALO_Pos_011.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20231010_MS_HEX-000681_GM_Neg-20231010_MS_HEX-000681_Cortex_GM_Neg_011.mzML
SUBJECT_SAMPLE_FACTORS           	Cortex_pool-2	HSA-000035023	genotype:NA | Sample source:brain	sex=NA; age=4.5; age_unit=month; region=Cortex; RAW_FILE_NAME(Raw Source Name.PITC)=20231013_MS_HEX-000681_PITC_Pos-20231013_MS_HEX-000681_Cortex_PITC_Pos_012.mzML; RAW_FILE_NAME(Raw Source Name.LP)=20231006_MS_HEX-000681_Lipid_Pos-20231006_MS_HEX-000681_Cortex_Lipid_Pos_012.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20231008_MS_HEX-000681_Lipid_Neg-20231008_MS_HEX-000681_Cortex_Lipid_Neg_012.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20231007_MS_HEX-000681_Met_Pos-20231007_MS_HEX-000681_Cortex_Met_Pos_012.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20231008_MS_HEX-000681_Met_Neg-20231008_MS_HEX-000681_Cortex_Met_Neg_012.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20231007_MS_HEX-000681_HALO_Pos-20231007_MS_HEX-000681_Cortex_HALO_Pos_012.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20231010_MS_HEX-000681_GM_Neg-20231010_MS_HEX-000681_Cortex_GM_Neg_012.mzML
SUBJECT_SAMPLE_FACTORS           	Cortex_17	HSA-000034480	genotype:HOM KO ATP13A2 | Sample source:brain	sex=Female; age=4.5; age_unit=month; region=Cortex; RAW_FILE_NAME(Raw Source Name.PITC)=20231013_MS_HEX-000681_PITC_Pos-20231013_MS_HEX-000681_Cortex_PITC_Pos_013.mzML; RAW_FILE_NAME(Raw Source Name.LP)=20231006_MS_HEX-000681_Lipid_Pos-20231006_MS_HEX-000681_Cortex_Lipid_Pos_013.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20231008_MS_HEX-000681_Lipid_Neg-20231008_MS_HEX-000681_Cortex_Lipid_Neg_013.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20231007_MS_HEX-000681_Met_Pos-20231007_MS_HEX-000681_Cortex_Met_Pos_013.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20231008_MS_HEX-000681_Met_Neg-20231008_MS_HEX-000681_Cortex_Met_Neg_013.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20231007_MS_HEX-000681_HALO_Pos-20231007_MS_HEX-000681_Cortex_HALO_Pos_013.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20231010_MS_HEX-000681_GM_Neg-20231010_MS_HEX-000681_Cortex_GM_Neg_013.mzML
SUBJECT_SAMPLE_FACTORS           	Cortex_11	HSA-000034474	genotype:HOM KO ATP13A2 | Sample source:brain	sex=Female; age=4.5; age_unit=month; region=Cortex; RAW_FILE_NAME(Raw Source Name.PITC)=20231013_MS_HEX-000681_PITC_Pos-20231013_MS_HEX-000681_Cortex_PITC_Pos_014.mzML; RAW_FILE_NAME(Raw Source Name.LP)=20231006_MS_HEX-000681_Lipid_Pos-20231006_MS_HEX-000681_Cortex_Lipid_Pos_014.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20231008_MS_HEX-000681_Lipid_Neg-20231008_MS_HEX-000681_Cortex_Lipid_Neg_014.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20231007_MS_HEX-000681_Met_Pos-20231007_MS_HEX-000681_Cortex_Met_Pos_014.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20231008_MS_HEX-000681_Met_Neg-20231008_MS_HEX-000681_Cortex_Met_Neg_014.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20231007_MS_HEX-000681_HALO_Pos-20231007_MS_HEX-000681_Cortex_HALO_Pos_014.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20231010_MS_HEX-000681_GM_Neg-20231010_MS_HEX-000681_Cortex_GM_Neg_014.mzML
SUBJECT_SAMPLE_FACTORS           	Cortex_12	HSA-000034475	genotype:HET KO ATP13A2 | Sample source:brain	sex=Male; age=4.5; age_unit=month; region=Cortex; RAW_FILE_NAME(Raw Source Name.PITC)=20231013_MS_HEX-000681_PITC_Pos-20231013_MS_HEX-000681_Cortex_PITC_Pos_015.mzML; RAW_FILE_NAME(Raw Source Name.LP)=20231006_MS_HEX-000681_Lipid_Pos-20231006_MS_HEX-000681_Cortex_Lipid_Pos_015.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20231008_MS_HEX-000681_Lipid_Neg-20231008_MS_HEX-000681_Cortex_Lipid_Neg_015.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20231007_MS_HEX-000681_Met_Pos-20231007_MS_HEX-000681_Cortex_Met_Pos_015.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20231008_MS_HEX-000681_Met_Neg-20231008_MS_HEX-000681_Cortex_Met_Neg_015.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20231007_MS_HEX-000681_HALO_Pos-20231007_MS_HEX-000681_Cortex_HALO_Pos_015.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20231010_MS_HEX-000681_GM_Neg-20231010_MS_HEX-000681_Cortex_GM_Neg_015.mzML
SUBJECT_SAMPLE_FACTORS           	Cortex_01	HSA-000034464	genotype:WT | Sample source:brain	sex=Female; age=4.5; age_unit=month; region=Cortex; RAW_FILE_NAME(Raw Source Name.PITC)=20231013_MS_HEX-000681_PITC_Pos-20231013_MS_HEX-000681_Cortex_PITC_Pos_016.mzML; RAW_FILE_NAME(Raw Source Name.LP)=20231006_MS_HEX-000681_Lipid_Pos-20231006_MS_HEX-000681_Cortex_Lipid_Pos_016.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20231008_MS_HEX-000681_Lipid_Neg-20231008_MS_HEX-000681_Cortex_Lipid_Neg_016.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20231007_MS_HEX-000681_Met_Pos-20231007_MS_HEX-000681_Cortex_Met_Pos_016.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20231008_MS_HEX-000681_Met_Neg-20231008_MS_HEX-000681_Cortex_Met_Neg_016.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20231007_MS_HEX-000681_HALO_Pos-20231007_MS_HEX-000681_Cortex_HALO_Pos_016.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20231010_MS_HEX-000681_GM_Neg-20231010_MS_HEX-000681_Cortex_GM_Neg_016.mzML
SUBJECT_SAMPLE_FACTORS           	Cortex_13	HSA-000034476	genotype:WT | Sample source:brain	sex=Male; age=4.5; age_unit=month; region=Cortex; RAW_FILE_NAME(Raw Source Name.PITC)=20231013_MS_HEX-000681_PITC_Pos-20231013_MS_HEX-000681_Cortex_PITC_Pos_017.mzML; RAW_FILE_NAME(Raw Source Name.LP)=20231006_MS_HEX-000681_Lipid_Pos-20231006_MS_HEX-000681_Cortex_Lipid_Pos_017.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20231008_MS_HEX-000681_Lipid_Neg-20231008_MS_HEX-000681_Cortex_Lipid_Neg_017.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20231007_MS_HEX-000681_Met_Pos-20231007_MS_HEX-000681_Cortex_Met_Pos_017.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20231008_MS_HEX-000681_Met_Neg-20231008_MS_HEX-000681_Cortex_Met_Neg_017.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20231007_MS_HEX-000681_HALO_Pos-20231007_MS_HEX-000681_Cortex_HALO_Pos_017.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20231010_MS_HEX-000681_GM_Neg-20231010_MS_HEX-000681_Cortex_GM_Neg_017.mzML
SUBJECT_SAMPLE_FACTORS           	Cortex_19	HSA-000034482	genotype:WT | Sample source:brain	sex=Female; age=4.5; age_unit=month; region=Cortex; RAW_FILE_NAME(Raw Source Name.PITC)=20231013_MS_HEX-000681_PITC_Pos-20231013_MS_HEX-000681_Cortex_PITC_Pos_018.mzML; RAW_FILE_NAME(Raw Source Name.LP)=20231006_MS_HEX-000681_Lipid_Pos-20231006_MS_HEX-000681_Cortex_Lipid_Pos_018.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20231008_MS_HEX-000681_Lipid_Neg-20231008_MS_HEX-000681_Cortex_Lipid_Neg_018.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20231007_MS_HEX-000681_Met_Pos-20231007_MS_HEX-000681_Cortex_Met_Pos_018.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20231008_MS_HEX-000681_Met_Neg-20231008_MS_HEX-000681_Cortex_Met_Neg_018.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20231007_MS_HEX-000681_HALO_Pos-20231007_MS_HEX-000681_Cortex_HALO_Pos_018.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20231010_MS_HEX-000681_GM_Neg-20231010_MS_HEX-000681_Cortex_GM_Neg_018.mzML
SUBJECT_SAMPLE_FACTORS           	Cortex_02	HSA-000034465	genotype:HOM KO ATP13A2 | Sample source:brain	sex=Male; age=4.5; age_unit=month; region=Cortex; RAW_FILE_NAME(Raw Source Name.PITC)=20231013_MS_HEX-000681_PITC_Pos-20231013_MS_HEX-000681_Cortex_PITC_Pos_019.mzML; RAW_FILE_NAME(Raw Source Name.LP)=20231006_MS_HEX-000681_Lipid_Pos-20231006_MS_HEX-000681_Cortex_Lipid_Pos_019.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20231008_MS_HEX-000681_Lipid_Neg-20231008_MS_HEX-000681_Cortex_Lipid_Neg_019.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20231007_MS_HEX-000681_Met_Pos-20231007_MS_HEX-000681_Cortex_Met_Pos_019.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20231008_MS_HEX-000681_Met_Neg-20231008_MS_HEX-000681_Cortex_Met_Neg_019.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20231007_MS_HEX-000681_HALO_Pos-20231007_MS_HEX-000681_Cortex_HALO_Pos_019.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20231010_MS_HEX-000681_GM_Neg-20231010_MS_HEX-000681_Cortex_GM_Neg_019.mzML
SUBJECT_SAMPLE_FACTORS           	Cortex_05	HSA-000034468	genotype:HOM KO ATP13A2 | Sample source:brain	sex=Male; age=4.5; age_unit=month; region=Cortex; RAW_FILE_NAME(Raw Source Name.PITC)=20231013_MS_HEX-000681_PITC_Pos-20231013_MS_HEX-000681_Cortex_PITC_Pos_020.mzML; RAW_FILE_NAME(Raw Source Name.LP)=20231006_MS_HEX-000681_Lipid_Pos-20231006_MS_HEX-000681_Cortex_Lipid_Pos_020.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20231008_MS_HEX-000681_Lipid_Neg-20231008_MS_HEX-000681_Cortex_Lipid_Neg_020.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20231007_MS_HEX-000681_Met_Pos-20231007_MS_HEX-000681_Cortex_Met_Pos_020.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20231008_MS_HEX-000681_Met_Neg-20231008_MS_HEX-000681_Cortex_Met_Neg_020.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20231007_MS_HEX-000681_HALO_Pos-20231007_MS_HEX-000681_Cortex_HALO_Pos_020.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20231010_MS_HEX-000681_GM_Neg-20231010_MS_HEX-000681_Cortex_GM_Neg_020.mzML
SUBJECT_SAMPLE_FACTORS           	Cortex_10	HSA-000034473	genotype:WT | Sample source:brain	sex=Male; age=4.5; age_unit=month; region=Cortex; RAW_FILE_NAME(Raw Source Name.PITC)=20231013_MS_HEX-000681_PITC_Pos-20231013_MS_HEX-000681_Cortex_PITC_Pos_021.mzML; RAW_FILE_NAME(Raw Source Name.LP)=20231006_MS_HEX-000681_Lipid_Pos-20231006_MS_HEX-000681_Cortex_Lipid_Pos_021.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20231008_MS_HEX-000681_Lipid_Neg-20231008_MS_HEX-000681_Cortex_Lipid_Neg_021.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20231007_MS_HEX-000681_Met_Pos-20231007_MS_HEX-000681_Cortex_Met_Pos_021.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20231008_MS_HEX-000681_Met_Neg-20231008_MS_HEX-000681_Cortex_Met_Neg_021.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20231007_MS_HEX-000681_HALO_Pos-20231007_MS_HEX-000681_Cortex_HALO_Pos_021.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20231010_MS_HEX-000681_GM_Neg-20231010_MS_HEX-000681_Cortex_GM_Neg_021.mzML
SUBJECT_SAMPLE_FACTORS           	Cortex_06	HSA-000034469	genotype:HET KO ATP13A2 | Sample source:brain	sex=Male; age=4.5; age_unit=month; region=Cortex; RAW_FILE_NAME(Raw Source Name.PITC)=20231013_MS_HEX-000681_PITC_Pos-20231013_MS_HEX-000681_Cortex_PITC_Pos_022.mzML; RAW_FILE_NAME(Raw Source Name.LP)=20231006_MS_HEX-000681_Lipid_Pos-20231006_MS_HEX-000681_Cortex_Lipid_Pos_022.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20231008_MS_HEX-000681_Lipid_Neg-20231008_MS_HEX-000681_Cortex_Lipid_Neg_022.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20231007_MS_HEX-000681_Met_Pos-20231007_MS_HEX-000681_Cortex_Met_Pos_022.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20231008_MS_HEX-000681_Met_Neg-20231008_MS_HEX-000681_Cortex_Met_Neg_022.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20231007_MS_HEX-000681_HALO_Pos-20231007_MS_HEX-000681_Cortex_HALO_Pos_022.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20231010_MS_HEX-000681_GM_Neg-20231010_MS_HEX-000681_Cortex_GM_Neg_022.mzML
SUBJECT_SAMPLE_FACTORS           	Cortex_pool-3	HSA-000035024	genotype:NA | Sample source:brain	sex=NA; age=4.5; age_unit=month; region=Cortex; RAW_FILE_NAME(Raw Source Name.PITC)=20231013_MS_HEX-000681_PITC_Pos-20231013_MS_HEX-000681_Cortex_PITC_Pos_023.mzML; RAW_FILE_NAME(Raw Source Name.LP)=20231006_MS_HEX-000681_Lipid_Pos-20231006_MS_HEX-000681_Cortex_Lipid_Pos_023.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20231008_MS_HEX-000681_Lipid_Neg-20231008_MS_HEX-000681_Cortex_Lipid_Neg_023.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20231007_MS_HEX-000681_Met_Pos-20231007_MS_HEX-000681_Cortex_Met_Pos_023.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20231008_MS_HEX-000681_Met_Neg-20231008_MS_HEX-000681_Cortex_Met_Neg_023.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20231007_MS_HEX-000681_HALO_Pos-20231007_MS_HEX-000681_Cortex_HALO_Pos_023.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20231010_MS_HEX-000681_GM_Neg-20231010_MS_HEX-000681_Cortex_GM_Neg_023.mzML
SUBJECT_SAMPLE_FACTORS           	Hipp_pool-1	HSA-000034505	genotype:NA | Sample source:brain	sex=NA; age=4.5; age_unit=month; region=Hippocampus; RAW_FILE_NAME(Raw Source Name.PITC)=20231013_MS_HEX-000681_PITC_Pos-20231013_MS_HEX-000681_HC_PITC_Pos_001.mzML; RAW_FILE_NAME(Raw Source Name.LP)=20231006_MS_HEX-000681_Lipid_Pos-20231006_MS_HEX-000681_HC_Lipid_Pos_001.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20231008_MS_HEX-000681_Lipid_Neg-20231008_MS_HEX-000681_HC_Lipid_Neg_001.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20231007_MS_HEX-000681_Met_Pos-20231007_MS_HEX-000681_HC_Met_Pos_001.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20231008_MS_HEX-000681_Met_Neg-20231008_MS_HEX-000681_HC_Met_Neg_001.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20231007_MS_HEX-000681_HALO_Pos-20231007_MS_HEX-000681_HC_HALO_Pos_001.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20231010_MS_HEX-000681_GM_Neg-20231010_MS_HEX-000681_HC_GM_Neg_001.mzML
SUBJECT_SAMPLE_FACTORS           	Hipp_18	HSA-000034502	genotype:HET KO ATP13A2 | Sample source:brain	sex=Female; age=4.5; age_unit=month; region=Hippocampus; RAW_FILE_NAME(Raw Source Name.PITC)=20231013_MS_HEX-000681_PITC_Pos-20231013_MS_HEX-000681_HC_PITC_Pos_002.mzML; RAW_FILE_NAME(Raw Source Name.LP)=20231006_MS_HEX-000681_Lipid_Pos-20231006_MS_HEX-000681_HC_Lipid_Pos_002.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20231008_MS_HEX-000681_Lipid_Neg-20231008_MS_HEX-000681_HC_Lipid_Neg_002.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20231007_MS_HEX-000681_Met_Pos-20231007_MS_HEX-000681_HC_Met_Pos_002.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20231008_MS_HEX-000681_Met_Neg-20231008_MS_HEX-000681_HC_Met_Neg_002.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20231007_MS_HEX-000681_HALO_Pos-20231007_MS_HEX-000681_HC_HALO_Pos_002.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20231010_MS_HEX-000681_GM_Neg-20231010_MS_HEX-000681_HC_GM_Neg_002.mzML
SUBJECT_SAMPLE_FACTORS           	Hipp_06	HSA-000034490	genotype:HET KO ATP13A2 | Sample source:brain	sex=Male; age=4.5; age_unit=month; region=Hippocampus; RAW_FILE_NAME(Raw Source Name.PITC)=20231013_MS_HEX-000681_PITC_Pos-20231013_MS_HEX-000681_HC_PITC_Pos_003.mzML; RAW_FILE_NAME(Raw Source Name.LP)=20231006_MS_HEX-000681_Lipid_Pos-20231006_MS_HEX-000681_HC_Lipid_Pos_003.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20231008_MS_HEX-000681_Lipid_Neg-20231008_MS_HEX-000681_HC_Lipid_Neg_003.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20231007_MS_HEX-000681_Met_Pos-20231007_MS_HEX-000681_HC_Met_Pos_003.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20231008_MS_HEX-000681_Met_Neg-20231008_MS_HEX-000681_HC_Met_Neg_003.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20231007_MS_HEX-000681_HALO_Pos-20231007_MS_HEX-000681_HC_HALO_Pos_003.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20231010_MS_HEX-000681_GM_Neg-20231010_MS_HEX-000681_HC_GM_Neg_003.mzML
SUBJECT_SAMPLE_FACTORS           	Hipp_05	HSA-000034489	genotype:HOM KO ATP13A2 | Sample source:brain	sex=Male; age=4.5; age_unit=month; region=Hippocampus; RAW_FILE_NAME(Raw Source Name.PITC)=20231013_MS_HEX-000681_PITC_Pos-20231013_MS_HEX-000681_HC_PITC_Pos_004.mzML; RAW_FILE_NAME(Raw Source Name.LP)=20231006_MS_HEX-000681_Lipid_Pos-20231006_MS_HEX-000681_HC_Lipid_Pos_004.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20231008_MS_HEX-000681_Lipid_Neg-20231008_MS_HEX-000681_HC_Lipid_Neg_004.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20231007_MS_HEX-000681_Met_Pos-20231007_MS_HEX-000681_HC_Met_Pos_004.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20231008_MS_HEX-000681_Met_Neg-20231008_MS_HEX-000681_HC_Met_Neg_004.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20231007_MS_HEX-000681_HALO_Pos-20231007_MS_HEX-000681_HC_HALO_Pos_004.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20231010_MS_HEX-000681_GM_Neg-20231010_MS_HEX-000681_HC_GM_Neg_004.mzML
SUBJECT_SAMPLE_FACTORS           	Hipp_16	HSA-000034500	genotype:WT | Sample source:brain	sex=Female; age=4.5; age_unit=month; region=Hippocampus; RAW_FILE_NAME(Raw Source Name.PITC)=20231013_MS_HEX-000681_PITC_Pos-20231013_MS_HEX-000681_HC_PITC_Pos_005.mzML; RAW_FILE_NAME(Raw Source Name.LP)=20231006_MS_HEX-000681_Lipid_Pos-20231006_MS_HEX-000681_HC_Lipid_Pos_005.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20231008_MS_HEX-000681_Lipid_Neg-20231008_MS_HEX-000681_HC_Lipid_Neg_005.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20231007_MS_HEX-000681_Met_Pos-20231007_MS_HEX-000681_HC_Met_Pos_005.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20231008_MS_HEX-000681_Met_Neg-20231008_MS_HEX-000681_HC_Met_Neg_005.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20231007_MS_HEX-000681_HALO_Pos-20231007_MS_HEX-000681_HC_HALO_Pos_005.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20231010_MS_HEX-000681_GM_Neg-20231010_MS_HEX-000681_HC_GM_Neg_005.mzML
SUBJECT_SAMPLE_FACTORS           	Hipp_08	HSA-000034492	genotype:HOM KO ATP13A2 | Sample source:brain	sex=Female; age=4.5; age_unit=month; region=Hippocampus; RAW_FILE_NAME(Raw Source Name.PITC)=20231013_MS_HEX-000681_PITC_Pos-20231013_MS_HEX-000681_HC_PITC_Pos_006.mzML; RAW_FILE_NAME(Raw Source Name.LP)=20231006_MS_HEX-000681_Lipid_Pos-20231006_MS_HEX-000681_HC_Lipid_Pos_006.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20231008_MS_HEX-000681_Lipid_Neg-20231008_MS_HEX-000681_HC_Lipid_Neg_006.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20231007_MS_HEX-000681_Met_Pos-20231007_MS_HEX-000681_HC_Met_Pos_006.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20231008_MS_HEX-000681_Met_Neg-20231008_MS_HEX-000681_HC_Met_Neg_006.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20231007_MS_HEX-000681_HALO_Pos-20231007_MS_HEX-000681_HC_HALO_Pos_006.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20231010_MS_HEX-000681_GM_Neg-20231010_MS_HEX-000681_HC_GM_Neg_006.mzML
SUBJECT_SAMPLE_FACTORS           	Hipp_03	HSA-000034487	genotype:HET KO ATP13A2 | Sample source:brain	sex=Male; age=4.5; age_unit=month; region=Hippocampus; RAW_FILE_NAME(Raw Source Name.PITC)=20231013_MS_HEX-000681_PITC_Pos-20231013_MS_HEX-000681_HC_PITC_Pos_007.mzML; RAW_FILE_NAME(Raw Source Name.LP)=20231006_MS_HEX-000681_Lipid_Pos-20231006_MS_HEX-000681_HC_Lipid_Pos_007.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20231008_MS_HEX-000681_Lipid_Neg-20231008_MS_HEX-000681_HC_Lipid_Neg_007.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20231007_MS_HEX-000681_Met_Pos-20231007_MS_HEX-000681_HC_Met_Pos_007.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20231008_MS_HEX-000681_Met_Neg-20231008_MS_HEX-000681_HC_Met_Neg_007.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20231007_MS_HEX-000681_HALO_Pos-20231007_MS_HEX-000681_HC_HALO_Pos_007.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20231010_MS_HEX-000681_GM_Neg-20231010_MS_HEX-000681_HC_GM_Neg_007.mzML
SUBJECT_SAMPLE_FACTORS           	Hipp_01	HSA-000034485	genotype:WT | Sample source:brain	sex=Female; age=4.5; age_unit=month; region=Hippocampus; RAW_FILE_NAME(Raw Source Name.PITC)=20231013_MS_HEX-000681_PITC_Pos-20231013_MS_HEX-000681_HC_PITC_Pos_008.mzML; RAW_FILE_NAME(Raw Source Name.LP)=20231006_MS_HEX-000681_Lipid_Pos-20231006_MS_HEX-000681_HC_Lipid_Pos_008.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20231008_MS_HEX-000681_Lipid_Neg-20231008_MS_HEX-000681_HC_Lipid_Neg_008.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20231007_MS_HEX-000681_Met_Pos-20231007_MS_HEX-000681_HC_Met_Pos_008.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20231008_MS_HEX-000681_Met_Neg-20231008_MS_HEX-000681_HC_Met_Neg_008.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20231007_MS_HEX-000681_HALO_Pos-20231007_MS_HEX-000681_HC_HALO_Pos_008.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20231010_MS_HEX-000681_GM_Neg-20231010_MS_HEX-000681_HC_GM_Neg_008.mzML
SUBJECT_SAMPLE_FACTORS           	Hipp_20	HSA-000034504	genotype:HOM KO ATP13A2 | Sample source:brain	sex=Female; age=4.5; age_unit=month; region=Hippocampus; RAW_FILE_NAME(Raw Source Name.PITC)=20231013_MS_HEX-000681_PITC_Pos-20231013_MS_HEX-000681_HC_PITC_Pos_009.mzML; RAW_FILE_NAME(Raw Source Name.LP)=20231006_MS_HEX-000681_Lipid_Pos-20231006_MS_HEX-000681_HC_Lipid_Pos_009.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20231008_MS_HEX-000681_Lipid_Neg-20231008_MS_HEX-000681_HC_Lipid_Neg_009.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20231007_MS_HEX-000681_Met_Pos-20231007_MS_HEX-000681_HC_Met_Pos_009.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20231008_MS_HEX-000681_Met_Neg-20231008_MS_HEX-000681_HC_Met_Neg_009.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20231007_MS_HEX-000681_HALO_Pos-20231007_MS_HEX-000681_HC_HALO_Pos_009.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20231010_MS_HEX-000681_GM_Neg-20231010_MS_HEX-000681_HC_GM_Neg_009.mzML
SUBJECT_SAMPLE_FACTORS           	Hipp_13	HSA-000034497	genotype:WT | Sample source:brain	sex=Male; age=4.5; age_unit=month; region=Hippocampus; RAW_FILE_NAME(Raw Source Name.PITC)=20231013_MS_HEX-000681_PITC_Pos-20231013_MS_HEX-000681_HC_PITC_Pos_010.mzML; RAW_FILE_NAME(Raw Source Name.LP)=20231006_MS_HEX-000681_Lipid_Pos-20231006_MS_HEX-000681_HC_Lipid_Pos_010.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20231008_MS_HEX-000681_Lipid_Neg-20231008_MS_HEX-000681_HC_Lipid_Neg_010.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20231007_MS_HEX-000681_Met_Pos-20231007_MS_HEX-000681_HC_Met_Pos_010.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20231008_MS_HEX-000681_Met_Neg-20231008_MS_HEX-000681_HC_Met_Neg_010.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20231007_MS_HEX-000681_HALO_Pos-20231007_MS_HEX-000681_HC_HALO_Pos_010.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20231010_MS_HEX-000681_GM_Neg-20231010_MS_HEX-000681_HC_GM_Neg_010.mzML
SUBJECT_SAMPLE_FACTORS           	Hipp_pool-2	HSA-000035025	genotype:NA | Sample source:brain	sex=NA; age=4.5; age_unit=month; region=Hippocampus; RAW_FILE_NAME(Raw Source Name.PITC)=20231013_MS_HEX-000681_PITC_Pos-20231013_MS_HEX-000681_HC_PITC_Pos_011.mzML; RAW_FILE_NAME(Raw Source Name.LP)=20231006_MS_HEX-000681_Lipid_Pos-20231006_MS_HEX-000681_HC_Lipid_Pos_011.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20231008_MS_HEX-000681_Lipid_Neg-20231008_MS_HEX-000681_HC_Lipid_Neg_011.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20231007_MS_HEX-000681_Met_Pos-20231007_MS_HEX-000681_HC_Met_Pos_011.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20231008_MS_HEX-000681_Met_Neg-20231008_MS_HEX-000681_HC_Met_Neg_011.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20231007_MS_HEX-000681_HALO_Pos-20231007_MS_HEX-000681_HC_HALO_Pos_011.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20231010_MS_HEX-000681_GM_Neg-20231010_MS_HEX-000681_HC_GM_Neg_011.mzML
SUBJECT_SAMPLE_FACTORS           	Hipp_02	HSA-000034486	genotype:HOM KO ATP13A2 | Sample source:brain	sex=Male; age=4.5; age_unit=month; region=Hippocampus; RAW_FILE_NAME(Raw Source Name.PITC)=20231013_MS_HEX-000681_PITC_Pos-20231013_MS_HEX-000681_HC_PITC_Pos_012.mzML; RAW_FILE_NAME(Raw Source Name.LP)=20231006_MS_HEX-000681_Lipid_Pos-20231006_MS_HEX-000681_HC_Lipid_Pos_012.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20231008_MS_HEX-000681_Lipid_Neg-20231008_MS_HEX-000681_HC_Lipid_Neg_012.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20231007_MS_HEX-000681_Met_Pos-20231007_MS_HEX-000681_HC_Met_Pos_012.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20231008_MS_HEX-000681_Met_Neg-20231008_MS_HEX-000681_HC_Met_Neg_012.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20231007_MS_HEX-000681_HALO_Pos-20231007_MS_HEX-000681_HC_HALO_Pos_012.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20231010_MS_HEX-000681_GM_Neg-20231010_MS_HEX-000681_HC_GM_Neg_012.mzML
SUBJECT_SAMPLE_FACTORS           	Hipp_10	HSA-000034494	genotype:WT | Sample source:brain	sex=Male; age=4.5; age_unit=month; region=Hippocampus; RAW_FILE_NAME(Raw Source Name.PITC)=20231013_MS_HEX-000681_PITC_Pos-20231013_MS_HEX-000681_HC_PITC_Pos_013.mzML; RAW_FILE_NAME(Raw Source Name.LP)=20231006_MS_HEX-000681_Lipid_Pos-20231006_MS_HEX-000681_HC_Lipid_Pos_013.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20231008_MS_HEX-000681_Lipid_Neg-20231008_MS_HEX-000681_HC_Lipid_Neg_013.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20231007_MS_HEX-000681_Met_Pos-20231007_MS_HEX-000681_HC_Met_Pos_013.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20231008_MS_HEX-000681_Met_Neg-20231008_MS_HEX-000681_HC_Met_Neg_013.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20231007_MS_HEX-000681_HALO_Pos-20231007_MS_HEX-000681_HC_HALO_Pos_013.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20231010_MS_HEX-000681_GM_Neg-20231010_MS_HEX-000681_HC_GM_Neg_013.mzML
SUBJECT_SAMPLE_FACTORS           	Hipp_15	HSA-000034499	genotype:HET KO ATP13A2 | Sample source:brain	sex=Male; age=4.5; age_unit=month; region=Hippocampus; RAW_FILE_NAME(Raw Source Name.PITC)=20231013_MS_HEX-000681_PITC_Pos-20231013_MS_HEX-000681_HC_PITC_Pos_014.mzML; RAW_FILE_NAME(Raw Source Name.LP)=20231006_MS_HEX-000681_Lipid_Pos-20231006_MS_HEX-000681_HC_Lipid_Pos_014.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20231008_MS_HEX-000681_Lipid_Neg-20231008_MS_HEX-000681_HC_Lipid_Neg_014.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20231007_MS_HEX-000681_Met_Pos-20231007_MS_HEX-000681_HC_Met_Pos_014.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20231008_MS_HEX-000681_Met_Neg-20231008_MS_HEX-000681_HC_Met_Neg_014.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20231007_MS_HEX-000681_HALO_Pos-20231007_MS_HEX-000681_HC_HALO_Pos_014.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20231010_MS_HEX-000681_GM_Neg-20231010_MS_HEX-000681_HC_GM_Neg_014.mzML
SUBJECT_SAMPLE_FACTORS           	Hipp_14	HSA-000034498	genotype:HOM KO ATP13A2 | Sample source:brain	sex=Female; age=4.5; age_unit=month; region=Hippocampus; RAW_FILE_NAME(Raw Source Name.PITC)=20231013_MS_HEX-000681_PITC_Pos-20231013_MS_HEX-000681_HC_PITC_Pos_015.mzML; RAW_FILE_NAME(Raw Source Name.LP)=20231006_MS_HEX-000681_Lipid_Pos-20231006_MS_HEX-000681_HC_Lipid_Pos_015.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20231008_MS_HEX-000681_Lipid_Neg-20231008_MS_HEX-000681_HC_Lipid_Neg_015.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20231007_MS_HEX-000681_Met_Pos-20231007_MS_HEX-000681_HC_Met_Pos_015.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20231008_MS_HEX-000681_Met_Neg-20231008_MS_HEX-000681_HC_Met_Neg_015.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20231007_MS_HEX-000681_HALO_Pos-20231007_MS_HEX-000681_HC_HALO_Pos_015.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20231010_MS_HEX-000681_GM_Neg-20231010_MS_HEX-000681_HC_GM_Neg_015.mzML
SUBJECT_SAMPLE_FACTORS           	Hipp_11	HSA-000034495	genotype:HOM KO ATP13A2 | Sample source:brain	sex=Female; age=4.5; age_unit=month; region=Hippocampus; RAW_FILE_NAME(Raw Source Name.PITC)=20231013_MS_HEX-000681_PITC_Pos-20231013_MS_HEX-000681_HC_PITC_Pos_016.mzML; RAW_FILE_NAME(Raw Source Name.LP)=20231006_MS_HEX-000681_Lipid_Pos-20231006_MS_HEX-000681_HC_Lipid_Pos_016.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20231008_MS_HEX-000681_Lipid_Neg-20231008_MS_HEX-000681_HC_Lipid_Neg_016.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20231007_MS_HEX-000681_Met_Pos-20231007_MS_HEX-000681_HC_Met_Pos_016.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20231008_MS_HEX-000681_Met_Neg-20231008_MS_HEX-000681_HC_Met_Neg_016.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20231007_MS_HEX-000681_HALO_Pos-20231007_MS_HEX-000681_HC_HALO_Pos_016.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20231010_MS_HEX-000681_GM_Neg-20231010_MS_HEX-000681_HC_GM_Neg_016.mzML
SUBJECT_SAMPLE_FACTORS           	Hipp_19	HSA-000034503	genotype:WT | Sample source:brain	sex=Female; age=4.5; age_unit=month; region=Hippocampus; RAW_FILE_NAME(Raw Source Name.PITC)=20231013_MS_HEX-000681_PITC_Pos-20231013_MS_HEX-000681_HC_PITC_Pos_017.mzML; RAW_FILE_NAME(Raw Source Name.LP)=20231006_MS_HEX-000681_Lipid_Pos-20231006_MS_HEX-000681_HC_Lipid_Pos_017.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20231008_MS_HEX-000681_Lipid_Neg-20231008_MS_HEX-000681_HC_Lipid_Neg_017.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20231007_MS_HEX-000681_Met_Pos-20231007_MS_HEX-000681_HC_Met_Pos_017.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20231008_MS_HEX-000681_Met_Neg-20231008_MS_HEX-000681_HC_Met_Neg_017.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20231007_MS_HEX-000681_HALO_Pos-20231007_MS_HEX-000681_HC_HALO_Pos_017.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20231010_MS_HEX-000681_GM_Neg-20231010_MS_HEX-000681_HC_GM_Neg_017.mzML
SUBJECT_SAMPLE_FACTORS           	Hipp_09	HSA-000034493	genotype:HET KO ATP13A2 | Sample source:brain	sex=Male; age=4.5; age_unit=month; region=Hippocampus; RAW_FILE_NAME(Raw Source Name.PITC)=20231013_MS_HEX-000681_PITC_Pos-20231013_MS_HEX-000681_HC_PITC_Pos_018.mzML; RAW_FILE_NAME(Raw Source Name.LP)=20231006_MS_HEX-000681_Lipid_Pos-20231006_MS_HEX-000681_HC_Lipid_Pos_018.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20231008_MS_HEX-000681_Lipid_Neg-20231008_MS_HEX-000681_HC_Lipid_Neg_018.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20231007_MS_HEX-000681_Met_Pos-20231007_MS_HEX-000681_HC_Met_Pos_018.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20231008_MS_HEX-000681_Met_Neg-20231008_MS_HEX-000681_HC_Met_Neg_018.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20231007_MS_HEX-000681_HALO_Pos-20231007_MS_HEX-000681_HC_HALO_Pos_018.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20231010_MS_HEX-000681_GM_Neg-20231010_MS_HEX-000681_HC_GM_Neg_018.mzML
SUBJECT_SAMPLE_FACTORS           	Hipp_04	HSA-000034488	genotype:WT | Sample source:brain	sex=Female; age=4.5; age_unit=month; region=Hippocampus; RAW_FILE_NAME(Raw Source Name.PITC)=20231013_MS_HEX-000681_PITC_Pos-20231013_MS_HEX-000681_HC_PITC_Pos_019.mzML; RAW_FILE_NAME(Raw Source Name.LP)=20231006_MS_HEX-000681_Lipid_Pos-20231006_MS_HEX-000681_HC_Lipid_Pos_019.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20231008_MS_HEX-000681_Lipid_Neg-20231008_MS_HEX-000681_HC_Lipid_Neg_019.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20231007_MS_HEX-000681_Met_Pos-20231007_MS_HEX-000681_HC_Met_Pos_019.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20231008_MS_HEX-000681_Met_Neg-20231008_MS_HEX-000681_HC_Met_Neg_019.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20231007_MS_HEX-000681_HALO_Pos-20231007_MS_HEX-000681_HC_HALO_Pos_019.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20231010_MS_HEX-000681_GM_Neg-20231010_MS_HEX-000681_HC_GM_Neg_019.mzML
SUBJECT_SAMPLE_FACTORS           	Hipp_17	HSA-000034501	genotype:HOM KO ATP13A2 | Sample source:brain	sex=Female; age=4.5; age_unit=month; region=Hippocampus; RAW_FILE_NAME(Raw Source Name.PITC)=20231013_MS_HEX-000681_PITC_Pos-20231013_MS_HEX-000681_HC_PITC_Pos_020.mzML; RAW_FILE_NAME(Raw Source Name.LP)=20231006_MS_HEX-000681_Lipid_Pos-20231006_MS_HEX-000681_HC_Lipid_Pos_020.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20231008_MS_HEX-000681_Lipid_Neg-20231008_MS_HEX-000681_HC_Lipid_Neg_020.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20231007_MS_HEX-000681_Met_Pos-20231007_MS_HEX-000681_HC_Met_Pos_020.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20231008_MS_HEX-000681_Met_Neg-20231008_MS_HEX-000681_HC_Met_Neg_020.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20231007_MS_HEX-000681_HALO_Pos-20231007_MS_HEX-000681_HC_HALO_Pos_020.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20231010_MS_HEX-000681_GM_Neg-20231010_MS_HEX-000681_HC_GM_Neg_020.mzML
SUBJECT_SAMPLE_FACTORS           	Hipp_12	HSA-000034496	genotype:HET KO ATP13A2 | Sample source:brain	sex=Male; age=4.5; age_unit=month; region=Hippocampus; RAW_FILE_NAME(Raw Source Name.PITC)=20231013_MS_HEX-000681_PITC_Pos-20231013_MS_HEX-000681_HC_PITC_Pos_021.mzML; RAW_FILE_NAME(Raw Source Name.LP)=20231006_MS_HEX-000681_Lipid_Pos-20231006_MS_HEX-000681_HC_Lipid_Pos_021.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20231008_MS_HEX-000681_Lipid_Neg-20231008_MS_HEX-000681_HC_Lipid_Neg_021.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20231007_MS_HEX-000681_Met_Pos-20231007_MS_HEX-000681_HC_Met_Pos_021.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20231008_MS_HEX-000681_Met_Neg-20231008_MS_HEX-000681_HC_Met_Neg_021.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20231007_MS_HEX-000681_HALO_Pos-20231007_MS_HEX-000681_HC_HALO_Pos_021.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20231010_MS_HEX-000681_GM_Neg-20231010_MS_HEX-000681_HC_GM_Neg_021.mzML
SUBJECT_SAMPLE_FACTORS           	Hipp_07	HSA-000034491	genotype:WT | Sample source:brain	sex=Male; age=4.5; age_unit=month; region=Hippocampus; RAW_FILE_NAME(Raw Source Name.PITC)=20231013_MS_HEX-000681_PITC_Pos-20231013_MS_HEX-000681_HC_PITC_Pos_022.mzML; RAW_FILE_NAME(Raw Source Name.LP)=20231006_MS_HEX-000681_Lipid_Pos-20231006_MS_HEX-000681_HC_Lipid_Pos_022.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20231008_MS_HEX-000681_Lipid_Neg-20231008_MS_HEX-000681_HC_Lipid_Neg_022.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20231007_MS_HEX-000681_Met_Pos-20231007_MS_HEX-000681_HC_Met_Pos_022.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20231008_MS_HEX-000681_Met_Neg-20231008_MS_HEX-000681_HC_Met_Neg_022.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20231007_MS_HEX-000681_HALO_Pos-20231007_MS_HEX-000681_HC_HALO_Pos_022.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20231010_MS_HEX-000681_GM_Neg-20231010_MS_HEX-000681_HC_GM_Neg_022.mzML
SUBJECT_SAMPLE_FACTORS           	Hipp_pool-3	HSA-000035026	genotype:NA | Sample source:brain	sex=NA; age=4.5; age_unit=month; region=Hippocampus; RAW_FILE_NAME(Raw Source Name.PITC)=20231013_MS_HEX-000681_PITC_Pos-20231013_MS_HEX-000681_HC_PITC_Pos_023.mzML; RAW_FILE_NAME(Raw Source Name.LP)=20231006_MS_HEX-000681_Lipid_Pos-20231006_MS_HEX-000681_HC_Lipid_Pos_023.mzML; RAW_FILE_NAME(Raw Source Name.LN)=20231008_MS_HEX-000681_Lipid_Neg-20231008_MS_HEX-000681_HC_Lipid_Neg_023.mzML; RAW_FILE_NAME(Raw Source Name.MP)=20231007_MS_HEX-000681_Met_Pos-20231007_MS_HEX-000681_HC_Met_Pos_023.mzML; RAW_FILE_NAME(Raw Source Name.MN)=20231008_MS_HEX-000681_Met_Neg-20231008_MS_HEX-000681_HC_Met_Neg_023.mzML; RAW_FILE_NAME(Raw Source Name.HALO)=20231007_MS_HEX-000681_HALO_Pos-20231007_MS_HEX-000681_HC_HALO_Pos_023.mzML; RAW_FILE_NAME(Raw Source Name.GM)=20231010_MS_HEX-000681_GM_Neg-20231010_MS_HEX-000681_HC_GM_Neg_023.mzML
#COLLECTION
CO:COLLECTION_SUMMARY            	Heterozygous Atp13a2<tm1Pjsch> animals of genotype
CO:COLLECTION_SUMMARY            	B6N.129S6(Cg)-Atp13a2tm1Pjsch/J were obtained from The Jackson Laboratory (JAX
CO:COLLECTION_SUMMARY            	strain 021914)17 and were crossed to generate homozygous Atp13a2 KO (Atp13a2
CO:COLLECTION_SUMMARY            	–/–) animals. For both the 5-month and 15-month-old cohort, female and male
CO:COLLECTION_SUMMARY            	mice were used in comparable percentages (see table below). In case of the
CO:COLLECTION_SUMMARY            	15-month-old Atp13a2 KO cohort, one of the animals died prior to study
CO:COLLECTION_SUMMARY            	conclusion and was excluded. Animals were maintained and all procedures
CO:COLLECTION_SUMMARY            	performed in adherence to ethical regulations and protocols approved by the
CO:COLLECTION_SUMMARY            	Denali Therapeutics Inc. Institutional Animal Care and Use Committee (IACUC).
CO:COLLECTION_SUMMARY            	Mice were housed under a 12-h light/12-h dark cycle and had access to water and
CO:COLLECTION_SUMMARY            	standard rodent diet ad libitum. Running wheels were provided for enrichment to
CO:COLLECTION_SUMMARY            	the cohort that was aged to 15 months.Animals were deeply anesthetized via
CO:COLLECTION_SUMMARY            	intraperitoneal injection of 2.5% Avertin and transcardially perfused with
CO:COLLECTION_SUMMARY            	ice-cold PBS using a peristaltic pump (Gilson Inc. Minipuls Evolution). The
CO:COLLECTION_SUMMARY            	brain was then removed and one hemisphere sub-dissected into the anterior cortex
CO:COLLECTION_SUMMARY            	and hippocampus, while the other was retained without sub-dissection. Tissue
CO:COLLECTION_SUMMARY            	samples were individually weighed, flash frozen on dry ice and stored at -80°C
CO:COLLECTION_SUMMARY            	for subsequent analysis.
CO:SAMPLE_TYPE                   	Brain
CO:STORAGE_CONDITIONS            	-80℃
CO:COLLECTION_VIALS              	Lobind 1.5 mL Eppendorf tubes
CO:STORAGE_VIALS                 	Lobind 1.5 mL Eppendorf tubes
#TREATMENT
TR:TREATMENT_SUMMARY             	No treatment
#SAMPLEPREP
SP:SAMPLEPREP_SUMMARY            	For tissue samples, 20 (± 3) mg of anterior cortex or 15 (± 2) mg of
SP:SAMPLEPREP_SUMMARY            	hippocampus from the left hemisphere of each individual animal was dissected,
SP:SAMPLEPREP_SUMMARY            	weighed and flash frozen during tissue collection. Lipids and metabolites were
SP:SAMPLEPREP_SUMMARY            	extracted from the frozen samples using 400 mL of HPLC-grade methanol (Fisher
SP:SAMPLEPREP_SUMMARY            	Chemical; # A452-4) containing stable-isotope internal standards and homogenized
SP:SAMPLEPREP_SUMMARY            	with a 3 mm tungsten carbide bead for 45 s at 25 Hz on TissueLyzer II (QIAGEN,
SP:SAMPLEPREP_SUMMARY            	#85300). The methanol fraction was isolated via centrifugation (20 min at 4°C,
SP:SAMPLEPREP_SUMMARY            	14,000 x g, transferred to a 96-well sample collection plate (Waters;
SP:SAMPLEPREP_SUMMARY            	#186005837) and incubated for 1 h, at -20°C for protein precipitation,
SP:SAMPLEPREP_SUMMARY            	followed by an additional 20 min centrifugation (4,000 x g at 4°C). The
SP:SAMPLEPREP_SUMMARY            	supernatant was transferred to glass vial plates (Analytical systems, #27350)
SP:SAMPLEPREP_SUMMARY            	for LCMS analysis.
SP:PROCESSING_STORAGE_CONDITIONS 	On ice
SP:EXTRACT_STORAGE               	-20℃
#CHROMATOGRAPHY
CH:CHROMATOGRAPHY_SUMMARY        	Advanced Materials Technology HALO HILIC column (150 x 3.0 mm, 2um); #91813
CH:CHROMATOGRAPHY_TYPE           	HILIC
CH:INSTRUMENT_NAME               	Agilent 1290 Infinity II
CH:COLUMN_NAME                   	Advanced Materials Technology HALO HILIC (150 x 3.0 mm, 2um)
CH:SOLVENT_A                     	92.5% acetonitrile/5% isopropanol/2.5% water; 5 mM ammonium formate; 0.5% formic
CH:SOLVENT_A                     	acid
CH:SOLVENT_B                     	92.5% water/5% isopropanol/2.5% acetonitrile; 5 mM ammonium formate; 0.5% formic
CH:SOLVENT_B                     	acid
CH:FLOW_GRADIENT                 	0.0–2.0 min, 100% B; 2.1 min, 95% B; 4.5 min, 85% B; held at 85% B until 6.0
CH:FLOW_GRADIENT                 	min; 6.1 min, 0% B; held at 0% B until 8.5 min
CH:FLOW_RATE                     	0.45 mL/min
CH:COLUMN_TEMPERATURE            	45
#ANALYSIS
AN:ANALYSIS_TYPE                 	MS
#MS
MS:INSTRUMENT_NAME               	ABI Sciex 6500+ QTrap
MS:INSTRUMENT_TYPE               	Triple quadrupole
MS:MS_TYPE                       	ESI
MS:ION_MODE                      	POSITIVE
MS:MS_COMMENTS                   	curtain gas at 30 psi; collision gas set at medium; ion spray voltage at 4,500
MS:MS_COMMENTS                   	V; temperature at 600°C; ion source Gas 1 at 55 psi; ion source Gas 2 at 60
MS:MS_COMMENTS                   	psi.
#MS_METABOLITE_DATA
MS_METABOLITE_DATA:UNITS	normalized peak area
MS_METABOLITE_DATA_START
Samples	HSA-000038800	HSA-000038799	HSA-000038794	HSA-000038788	HSA-000038797	HSA-000038790	HSA-000038798	HSA-000038795	HSA-000039091	HSA-000038796	HSA-000038791	HSA-000038787	HSA-000038792	HSA-000038793	HSA-000038789	HSA-000039092	HSA-000038814	HSA-000038813	HSA-000038811	HSA-000038804	HSA-000038805	HSA-000038803	HSA-000038802	HSA-000038807	HSA-000039093	HSA-000038809	HSA-000038812	HSA-000038806	HSA-000038801	HSA-000038810	HSA-000038808	HSA-000039094	HSA-000034484	HSA-000034472	HSA-000034470	HSA-000034479	HSA-000034467	HSA-000034483	HSA-000034481	HSA-000034478	HSA-000034471	HSA-000034466	HSA-000034477	HSA-000035023	HSA-000034480	HSA-000034474	HSA-000034475	HSA-000034464	HSA-000034476	HSA-000034482	HSA-000034465	HSA-000034468	HSA-000034473	HSA-000034469	HSA-000035024	HSA-000034505	HSA-000034502	HSA-000034490	HSA-000034489	HSA-000034500	HSA-000034492	HSA-000034487	HSA-000034485	HSA-000034504	HSA-000034497	HSA-000035025	HSA-000034486	HSA-000034494	HSA-000034499	HSA-000034498	HSA-000034495	HSA-000034503	HSA-000034493	HSA-000034488	HSA-000034501	HSA-000034496	HSA-000034491	HSA-000035026
Factors	genotype:WT | Sample source:brain	genotype:HOM KO ATP13A2 | Sample source:brain	genotype:HOM KO ATP13A2 | Sample source:brain	genotype:WT | Sample source:brain	genotype:HOM KO ATP13A2 | Sample source:brain	genotype:HOM KO ATP13A2 | Sample source:brain	genotype:WT | Sample source:brain	genotype:NA | Sample source:brain	genotype:HOM KO ATP13A2 | Sample source:brain	genotype:WT | Sample source:brain	genotype:WT | Sample source:brain	genotype:HOM KO ATP13A2 | Sample source:brain	genotype:WT | Sample source:brain	genotype:WT | Sample source:brain	genotype:NA | Sample source:brain	genotype:NA | Sample source:brain	genotype:WT | Sample source:brain	genotype:WT | Sample source:brain	genotype:HOM KO ATP13A2 | Sample source:brain	genotype:WT | Sample source:brain	genotype:WT | Sample source:brain	genotype:HOM KO ATP13A2 | Sample source:brain	genotype:WT | Sample source:brain	genotype:NA | Sample source:brain	genotype:WT | Sample source:brain	genotype:HOM KO ATP13A2 | Sample source:brain	genotype:HOM KO ATP13A2 | Sample source:brain	genotype:WT | Sample source:brain	genotype:HOM KO ATP13A2 | Sample source:brain	genotype:HOM KO ATP13A2 | Sample source:brain	genotype:NA | Sample source:brain	genotype:NA | Sample source:brain	genotype:NA | Sample source:brain	genotype:HET KO ATP13A2 | Sample source:brain	genotype:WT | Sample source:brain	genotype:WT | Sample source:brain	genotype:WT | Sample source:brain	genotype:HOM KO ATP13A2 | Sample source:brain	genotype:HET KO ATP13A2 | Sample source:brain	genotype:HET KO ATP13A2 | Sample source:brain	genotype:HOM KO ATP13A2 | Sample source:brain	genotype:HET KO ATP13A2 | Sample source:brain	genotype:HOM KO ATP13A2 | Sample source:brain	genotype:NA | Sample source:brain	genotype:HOM KO ATP13A2 | Sample source:brain	genotype:HOM KO ATP13A2 | Sample source:brain	genotype:HET KO ATP13A2 | Sample source:brain	genotype:WT | Sample source:brain	genotype:WT | Sample source:brain	genotype:WT | Sample source:brain	genotype:HOM KO ATP13A2 | Sample source:brain	genotype:HOM KO ATP13A2 | Sample source:brain	genotype:WT | Sample source:brain	genotype:HET KO ATP13A2 | Sample source:brain	genotype:NA | Sample source:brain	genotype:NA | Sample source:brain	genotype:HET KO ATP13A2 | Sample source:brain	genotype:HET KO ATP13A2 | Sample source:brain	genotype:HOM KO ATP13A2 | Sample source:brain	genotype:WT | Sample source:brain	genotype:HOM KO ATP13A2 | Sample source:brain	genotype:HET KO ATP13A2 | Sample source:brain	genotype:WT | Sample source:brain	genotype:HOM KO ATP13A2 | Sample source:brain	genotype:WT | Sample source:brain	genotype:NA | Sample source:brain	genotype:HOM KO ATP13A2 | Sample source:brain	genotype:WT | Sample source:brain	genotype:HET KO ATP13A2 | Sample source:brain	genotype:HOM KO ATP13A2 | Sample source:brain	genotype:HOM KO ATP13A2 | Sample source:brain	genotype:WT | Sample source:brain	genotype:HET KO ATP13A2 | Sample source:brain	genotype:WT | Sample source:brain	genotype:HOM KO ATP13A2 | Sample source:brain	genotype:HET KO ATP13A2 | Sample source:brain	genotype:WT | Sample source:brain	genotype:NA | Sample source:brain
Cholesteryl galactoside	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.
Cholesteryl glucoside	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.
GalCer(d18:1/15:0)	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.
GalCer(d18:1/16:0)	1.114	0.908	0.821	1.155	1.046	0.99	2.726	0.683	1.039	1.141	1.141	0.967	0.953	1.177	1.027	1.002	1.144	1.403	1.678	0.923	1.365	1.451	0.855	1.291	1.232	1.253	1.682	1.463	1.196	1.498	1.33	1.263	2.791	1.837	0.958	1.706	2.388	2.319	2.443	1.751	1.437	2.214	1.791	1.508	2.09	1.76	1.56	2.715	2.442	1.979	1.009	2.099	2.256	0.94	1.974	1.503	1.268	1.872	1.372	1.323	2.72	2.14	1.831	1.277	1.742	1.616	1.917	1.552	0.587	1.824	2.314	1.656	1.4	3.86	1.313	1.463	1.572	1.598
GalCer(d18:1/18:0)	1.892	2.321	1.538	1.645	1.768	1.54	3.7	1.207	1.63	2.139	1.603	2.296	1.672	2.166	1.513	1.506	2.402	2.366	2.526	1.564	1.46	1.873	2.151	1.62	2.396	1.574	2.89	1.949	2.603	1.828	1.962	2.462	12.327	5.922	4.89	4.318	5.074	5.173	3.875	4.307	4.246	5.969	5.231	4.419	6.304	5.093	4.783	4.614	7.103	3.425	4.467	3.745	5.223	3.678	6.505	6.639	4.963	8.751	3.73	6.199	9.619	5.868	9.562	5.206	4.938	6.045	7.839	6.212	2.83	7.47	8.243	5.589	5.137	8.226	3.397	5.125	6.315	6.145
GalCer(d18:1/20:0)	0.51	0.579	0.523	0.452	0.71	0.631	1.054	0.496	0.508	0.761	0.452	0.647	0.61	0.743	0.53	0.533	0.491	0.716	0.722	0.577	0.431	0.437	0.377	0.591	0.466	0.463	0.851	0.647	0.467	0.748	0.534	0.534	0.792	0.712	0.433	0.478	0.43	0.6	0.533	0.396	0.527	0.42	0.579	0.499	0.58	0.628	0.348	0.366	0.56	0.663	0.363	0.514	0.475	0.552	0.517	0.592	0.646	0.713	0.418	0.8	0.566	0.567	0.756	0.535	0.63	0.447	1.089	0.511	0.285	0.601	1.254	0.606	0.619	0.734	0.306	0.653	0.628	0.67
GalCer(d18:1/22:0)	1.095	1.186	1.106	0.972	1.502	1.302	2.337	0.829	1.136	1.607	1.228	1.204	1.324	1.515	1.105	1.212	1.2	1.644	1.826	1.347	1.225	1.358	0.83	1.383	1.163	1.164	1.695	1.58	1.106	1.357	1.272	1.304	1.487	1.192	1.038	1.451	1.352	1.712	1.456	1.186	2.109	0.966	1.238	1.191	1.143	1.389	1.246	0.759	1.407	1.413	0.965	1.182	1.497	1.132	1.675	1.305	1.029	1.631	0.902	1.145	1.386	1.719	2.177	1.098	1.632	1.059	1.807	1.071	0.549	1.174	2.019	1.655	1.415	1.76	0.586	1.488	1.664	1.146
GalCer(d18:1/22:1)	15.151	14.128	12.224	10.665	17.408	15.822	26.713	11.349	12.787	18.403	17.198	13.495	13.617	17.389	15.222	13.068	15.37	22.087	26.714	17.878	16.753	15.216	9.689	15.675	15.732	14.944	19.534	20.353	14.335	16.217	14.919	17.175	14.363	12.829	9.743	11.864	16.964	20.812	16.268	12.531	15.388	15.868	17.035	12.307	22.024	15.479	11.498	8.593	20.627	15.573	9.402	16.948	16.524	10.193	16.91	17.714	9.189	15.654	8.783	11.977	23.398	21.736	18.958	11.374	13.259	9.258	20.768	10.912	4.185	11.05	17.788	13.956	11.896	18.053	5.434	19.089	13.55	9.844
GalCer(d18:1/24:0)	3.294	3.367	2.588	2.999	3.551	3.095	5.659	2.474	2.848	3.912	3.109	3.447	3.409	4.201	2.916	2.991	4.341	4.168	5.229	3.733	3.466	3.689	3.478	3.492	4.741	3.375	4.341	4.092	4.765	3.56	3.431	4.644	7.047	5.36	4.768	4.808	4.96	4.781	4.696	3.839	6.492	5.48	5.349	5.91	4.811	7.647	4.118	3.429	6.31	4.901	4.716	5.101	5.451	4.667	6.915	6.442	3.858	6.199	4.177	5.244	8.038	7.039	7.254	6.003	5.247	7.307	6.823	4.143	2.118	4.73	8.505	4.739	4.947	8.818	3.201	5.895	6.164	5.306
GalCer(d18:1/24:1)	41.718	47.01	36.094	38.766	43.517	40.817	75.137	28.776	37.692	47.591	46.037	41.812	40.744	48.111	32.436	35.721	52.23	46.812	61.069	45.335	42.784	43.505	42.061	39.905	57.255	38.539	55.679	58.35	51.424	49.749	42.805	60.097	81.963	87.254	65.545	74.102	68.639	65.224	63.573	46.125	71.455	100.872	63.522	75.412	83.955	75.811	73.042	44.916	74.226	72.225	59.739	50.157	70.507	50.1	70.668	72.863	49.769	81.008	47.649	84.295	79.089	79.999	89.012	50.992	67.67	57.669	105.23	64.973	27.075	72.444	122.88	70.712	51.273	109.96	34.651	73.641	69.473	64.456
GalCer(d18:2/18:0)	17.657	19.095	17.753	15.565	23.39	25.046	27.637	18.931	15.144	24.667	14.483	16.084	16.513	24.458	18.627	17.217	13.118	21.372	22.001	16.517	12.905	12.372	4.415	19.765	13.274	16.28	22.455	18.529	10.199	18.492	20.074	14.296	26.685	11.865	5.683	8.764	16.133	12.625	11.649	11.871	14.926	12.763	10.202	11.898	23.539	15.157	14.447	9.719	25.371	15.837	8.041	16.215	15.558	7.579	15.779	9.232	7.58	8.607	5.06	5.86	12.959	9.121	10.122	6.384	13.785	6.268	10.645	6.48	3.467	6.739	9.844	7.642	8.762	15.632	5.027	7.079	8.367	5.937
GalCer(d18:2/20:0)	10.507	13.869	12.988	10.082	16.796	16.173	16.124	10.45	9.446	16.282	6.866	9.84	12.06	16.49	11.764	10.844	8.263	14.623	12.294	10.782	6.197	7.914	3.39	13.54	9.903	9.4	14.143	12.078	6.463	12.334	11.867	9.243	6.174	3.585	2.534	4.085	4.779	5.32	5.907	3.456	6.687	4.13	3.212	3.576	7.515	4.292	3.74	2.39	6.455	4.754	2.591	5.006	5.986	2.825	5.104	2.919	3.493	3.114	1.877	2.072	3.229	4.796	2.497	2.971	3.265	2.127	4.29	1.797	1.013	3.253	3.396	4.022	3.045	3.819	1.582	2.737	2.538	2.993
GalCer(d18:2/22:0)	8.284	10.326	9.996	8.327	12.686	10.682	12.591	9.807	8.186	10.279	6.663	7.921	8.029	12.217	8.789	7.904	9.019	11.869	13.026	10.223	5.885	8.719	4.44	10.563	8.956	9.159	11.814	11.082	8.279	10.204	8.707	9.968	8.456	5.698	3.982	5.756	6.261	5.705	6.759	8.552	7	8.514	5.277	4.684	8.882	6.114	6.753	6.518	10.019	5.719	4.013	7.458	7.56	4.548	6.666	4.073	4.346	4.608	2.399	3.524	7.832	6.604	5.409	3.973	5.835	5.811	5.725	3.616	2.268	4.263	4.984	6.282	3.436	5.326	3.804	6.967	4.884	4.292
Galactosylsphingosine	0.537	0.534	0.468	0.47	0.654	0.61	1.346	0.542	0.587	0.741	0.616	0.707	0.642	0.639	0.61	0.665	0.723	1.12	1.187	0.854	0.983	0.919	0.456	1.217	0.732	0.97	0.945	1.018	0.631	1.087	0.883	0.836	0.094	0.245	0.103	0.156	0.459	0.56	0.629	0.369	0.368	0.474	0.389	0.427	0.631	0.569	0.445	0.442	0.759	1.02	0.328	0.535	0.665	0.371	0.355	0.465	0.157	0.438	0.198	0.135	0.492	0.398	0.36	0.217	0.251	0.297	0.379	0.37	0.083	0.161	0.386	0.286	0.456	0.511	0.189	0.402	0.333	0.301
GlcCer(d18:1(d5)/18:0)	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.
GlcCer(d18:1/16:0)	6.823	3.173	7.851	11.861	4.87	7.551	3.079	3.242	7.596	5.866	3.499	6.98	4.475	2.805	4.416	8.134	0.941	1.724	1.344	3.747	1.732	1.396	0.563	2.685	1.052	2.79	11.863	3.007	0.51	4.255	3.181	1.193	2.112	1.027	1.079	1.055	3.093	4.24	1.324	1.901	3.233	2.253	2.315	1.638	5.66	2.492	1.317	3.145	5.268	4.889	2.017	2.886	4.991	0.346	1.93	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.
GlcCer(d18:1/18:0)	15.02	11.543	12.269	17.987	11.781	10.586	14.974	11.815	14.255	17.811	14.641	14.35	14.647	15.331	10.004	14.784	4.326	7.29	8.593	9.636	7.444	5.674	3.542	9.079	4.738	7.512	23.909	10.72	3.271	11.619	10.274	4.95	8.333	8.302	4.539	12.885	12.781	16.659	17.913	10.537	12.995	19.743	20.4	17.591	27.879	11.273	9.41	15.908	32.524	13.511	8.973	12.588	28.882	6.521	11.909	8.723	6.18	5.904	9.331	5.351	8.124	9.505	6.302	6.973	6.85	6.223	6.994	4.296	6.03	5.702	11.375	4.892	5.198	8.291	5.573	8.525	8.081	7.252
GlcCer(d18:1/20:0)	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.
GlcCer(d18:1/22:0)	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.
GlcCer(d18:1/22:1)	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.
GlcCer(d18:1/24:0)	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.
GlcCer(d18:1/24:1)	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.
GlcCer(d18:2/18:0)	54.816	42.805	111.631	86.006	113.844	103.103	35.599	112.737	58.413	99.342	62.058	39.353	79.236	71.486	63.414	65.884	6.849	24.621	33.372	31.925	16.934	8.881	1.216	45.019	8.13	27.995	96.755	26.468	2.967	38.718	30.885	9.308	7.134	6.62	3.697	9.755	20.637	17.288	8.66	11.6	12.805	12.014	21.339	13.333	79.028	12.818	15.602	20.907	39.038	32.083	5.967	20.865	31.563	5.561	8.682	3.291	2.683	1.324	2.09	1.726	3.454	1.925	2.431	2.107	3.051	1.659	1.969	0.515	1.385	2.121	2.385	3.443	2.178	6.115	2.636	4.454	2.353	1.729
GlcCer(d18:2/20:0)	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.
GlcCer(d18:2/22:0)	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.
Glucosylsphingosine	0.146	0.108	0.16	0.169	0.113	0.188	0.138	0.1	0.154	0.253	0.127	0.152	0.188	0.133	0.139	0.166	0.09	0.076	0.079	0.128	0.087	0.062	0.05	0.078	0.088	0.078	0.268	0.12	0.07	0.164	0.153	0.09	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.
Glucosylsphingosine(d5)	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.
Sitosteryl galactoside	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.
Sitosteryl glucoside	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.
alpha-GalCer(d18:1/16:0)	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.
alpha-GalCer(d18:1/18:0)	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.
alpha-GalCer(d18:1/20:0)	0.044	0.037	0.034	0.035	0.048	0.044	0.075	0.025	0.043	0.052	0.047	0.038	0.039	0.042	0.038	0.038	0.041	0.055	0.06	0.045	0.061	0.045	0.026	0.053	0.046	0.049	0.051	0.051	0.044	0.044	0.048	0.052	0.259	0.268	0.25	0.218	0.203	0.284	0.231	0.18	0.21	0.16	0.196	0.205	0.224	0.16	0.164	0.125	0.227	0.242	0.222	0.204	0.196	0.202	0.282	0.283	0.24	0.291	0.244	0.277	0.256	0.32	0.42	0.288	0.238	0.3	0.435	0.239	0.224	0.196	0.391	0.316	0.249	0.27	0.185	0.295	0.327	0.284
alpha-GalCer(d18:1/22:0)	0.069	0.073	0.056	0.057	0.063	0.067	0.118	0.045	0.064	0.085	0.079	0.065	0.062	0.077	0.055	0.057	0.074	0.089	0.108	0.074	0.086	0.072	0.055	0.076	0.076	0.07	0.084	0.08	0.096	0.076	0.065	0.078	0.855	0.792	0.709	0.617	0.656	0.762	0.683	0.483	0.604	0.556	0.652	0.507	0.552	0.563	0.526	0.41	0.701	0.662	0.542	0.534	0.631	0.488	0.803	0.821	0.513	0.684	0.583	0.662	0.733	0.828	1.117	0.661	0.507	0.753	0.928	0.554	0.633	0.596	0.879	0.683	0.511	0.703	0.464	0.731	0.821	0.705
alpha-GalCer(d18:1/22:1)	1.205	1.244	0.921	0.925	1.106	1.051	2.074	0.83	1.143	1.332	1.366	1.152	1.086	1.379	0.909	1.019	1.458	1.461	1.74	1.209	1.419	1.336	1.052	1.075	1.383	1.192	1.364	1.428	1.785	1.251	1.074	1.502	17.433	18.886	14.259	13.785	14.366	17.69	16.114	10.825	15.011	13.04	13.882	11.859	12.429	13.061	12.428	9.275	16.94	15.516	12.801	14.029	14.098	10.615	16.149	17.548	11.478	15.632	12.385	14.77	18.685	19.164	23.817	14.419	13.104	17.154	21.631	12.938	10.833	13.508	20.075	16.451	13.622	17.037	9.623	16.813	16.799	15.537
alpha-GalCer(d18:1/24:0)	0.127	0.129	0.126	0.111	0.119	0.127	0.304	0.075	0.162	0.181	0.254	0.188	0.123	0.183	0.123	0.125	0.242	0.21	0.25	0.175	0.282	0.211	0.248	0.171	0.249	0.157	0.221	0.238	0.388	0.152	0.166	0.229	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.
alpha-GalCer(d18:1/24:1)	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.
alpha-GalCer(d18:2/20:0)	0.825	0.9	0.814	0.762	1.012	0.997	1.376	0.768	0.838	1.053	0.879	0.748	0.87	1.193	0.83	0.763	0.959	1.086	1.227	0.946	0.851	0.951	0.424	1.042	0.902	0.971	1.031	1.003	1.124	0.912	0.903	0.901	4.87	4.95	2.534	3.957	4.032	5.554	5.682	3.474	4.491	4.102	3.594	3.182	4.026	3.99	4.03	2.549	5.214	5.117	3.193	4.944	3.752	2.777	4.365	3.509	3.359	3.376	2.051	2.843	4.562	4.667	4.162	2.971	3.542	3.373	4.009	2.33	1.55	2.907	4.015	4.219	2.97	3.941	2.184	3.717	3.396	3.227
alpha-GalCer(d18:2/22:0)	1.532	1.837	1.335	1.36	1.659	1.551	2.106	1.291	1.485	1.824	1.384	1.417	1.559	1.974	1.364	1.384	1.924	1.92	2.227	1.735	1.31	1.776	1.245	1.6	1.897	1.636	1.699	1.782	2.492	1.635	1.444	2.005	13.548	15.543	9.705	11.877	10.311	13.705	12.829	10.14	12.282	12.505	11.056	9.25	9.586	10.849	11.936	7.23	13.264	11.599	11.049	12.819	11.016	9.197	12.711	10.87	9.535	9.959	6.833	8.816	12.113	14.411	13.183	9.233	11.305	10.524	12.827	8.277	5.604	9.459	12.112	12.227	8.904	12.703	6.996	11.961	11.677	9.481
alpha-GalCer(d18:2/:18:0)	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.	4.123	3.007	1.829	3.002	3.778	4.177	4.185	2.587	2.937	2.776	2.699	2.468	4.037	2.708	3.091	2.298	4.949	4.446	2.026	4.154	3.505	1.698	3.409	2.446	1.943	2.532	1.309	1.971	3.171	3.25	3.363	1.975	2.495	2.212	2.839	1.698	0.98	2.157	2.774	2.869	1.994	3.198	1.525	2.384	2.641	2.18
MS_METABOLITE_DATA_END
#METABOLITES
METABOLITES_START
metabolite_name	Expected RT	MS1_mz	MS2_mz
alpha-GalCer(d18:1/16:0)	2.31	700.6	264.3
alpha-GalCer(d18:1/18:0)	2.28	728.6	264.3
alpha-GalCer(d18:1/20:0)	2.26	756.6	264.3
alpha-GalCer(d18:1/22:0)	2.17	784.7	264.3
alpha-GalCer(d18:1/22:1)	2.18	782.7	264.3
alpha-GalCer(d18:1/24:0)	2.16	812.7	264.3
alpha-GalCer(d18:1/24:1)	2.17	810.7	264.3
alpha-GalCer(d18:2/:18:0)	2.28	726.6	262.3
alpha-GalCer(d18:2/20:0)	2.23	754.6	262.3
alpha-GalCer(d18:2/22:0)	2.17	782.7	262.3
Cholesteryl galactoside	1.83	566.6	369.3
Cholesteryl glucoside	1.76	566.6	369.3
Galactosylsphingosine	6.4	462.2	282.3
GalCer(d18:1/15:0)	2.05	686.3	264.3
GalCer(d18:1/16:0)	2.14	700.6	264.3
GalCer(d18:1/18:0)	2.1	728.6	264.3
GalCer(d18:1/20:0)	2.05	756.6	264.3
GalCer(d18:1/22:0)	2.02	784.7	264.3
GalCer(d18:1/22:1)	2.02	782.7	264.3
GalCer(d18:1/24:0)	1.98	812.7	264.3
GalCer(d18:1/24:1)	1.98	810.7	264.3
GalCer(d18:2/18:0)	2.1	726.6	262.3
GalCer(d18:2/20:0)	2.05	754.6	262.3
GalCer(d18:2/22:0)	2	782.7	262.3
GlcCer(d18:1(d5)/18:0)	1.92	733.6	269.3
GlcCer(d18:1/16:0)	2	700.6	264.3
GlcCer(d18:1/18:0)	1.93	728.6	264.3
GlcCer(d18:1/20:0)	1.89	756.6	264.3
GlcCer(d18:1/22:0)	1.86	784.7	264.3
GlcCer(d18:1/22:1)	1.87	782.7	264.3
GlcCer(d18:1/24:0)	1.84	812.7	264.3
GlcCer(d18:1/24:1)	1.84	810.7	264.3
GlcCer(d18:2/18:0)	1.93	726.6	262.3
GlcCer(d18:2/20:0)	1.89	754.6	262.3
GlcCer(d18:2/22:0)	1.87	782.7	262.3
Glucosylsphingosine	6.2	462.2	282.3
Glucosylsphingosine(d5)	6.2	467.2	287.3
Sitosteryl galactoside	1.76	594.6	397.4
Sitosteryl glucoside	1.76	594.6	397.4
METABOLITES_END
#END