#METABOLOMICS WORKBENCH mjackstadt1_20250701_085437 DATATRACK_ID:6120 STUDY_ID:ST004074 ANALYSIS_ID:AN006744 PROJECT_ID:PR002557 VERSION 1 CREATED_ON July 24, 2025, 12:21 pm #PROJECT PR:PROJECT_TITLE Intestine-derived sorbitol drives steatotic liver disease in the absence of gut PR:PROJECT_TITLE bacteria PR:PROJECT_SUMMARY The role of the gut microbiome in mediating steatotic liver disease is poorly PR:PROJECT_SUMMARY understood. Here, we developed a model to deplete the gut microbiome in adult PR:PROJECT_SUMMARY zebrafish and discovered that it led to steatotic liver disease in animals on PR:PROJECT_SUMMARY standard diets. Using metabolomics and isotope tracing, we found that dietary PR:PROJECT_SUMMARY glucose is transformed into sorbitol within the intestine. While bacteria PR:PROJECT_SUMMARY degrade the sorbitol in control animals, sorbitol is passed to the livers of PR:PROJECT_SUMMARY fish in which the gut microbiome has been depleted. Within the liver, sorbitol PR:PROJECT_SUMMARY is converted into fructose 1-phosphate, which subsequently activates PR:PROJECT_SUMMARY glucokinase. The result is increased hepatic metabolism of glucose, leading to PR:PROJECT_SUMMARY elevated glycogen and fat content. Inhibition of sorbitol production in PR:PROJECT_SUMMARY microbiome-depleted animals was sufficient to prevent the development of PR:PROJECT_SUMMARY steatotic liver, and colonizing sorbitol-degrading bacteria in the intestines of PR:PROJECT_SUMMARY microbiome-depleted fish reversed the steatotic liver phenotype. Taken together, PR:PROJECT_SUMMARY these findings show that sorbitol-degrading bacteria in the gut protect against PR:PROJECT_SUMMARY steatotic liver disease. PR:INSTITUTE Washington University in St. Louis PR:LAST_NAME Jackstadt PR:FIRST_NAME Madelyn PR:ADDRESS One Brookings Drive, St. Louis, Missouri, 63130, USA PR:EMAIL mjackstadt@wustl.edu PR:PHONE 3149356405 #STUDY ST:STUDY_TITLE Metabolite Pools in Adult Zebrafish Treated with Antimicrobials or Control ST:STUDY_SUMMARY To examine alterations to metabolism as a result of gut microbiota depletion, we ST:STUDY_SUMMARY exposed adult zebrafish to treatment with antimicrobials or untreated control ST:STUDY_SUMMARY and analyzed systemic metabolite pools. We identified various changes in tissues ST:STUDY_SUMMARY across the fish, including in the brain, eye, fin, heart, intestine, liver, ST:STUDY_SUMMARY muscle, and serum. ST:INSTITUTE Washington University in St. Louis ST:LAST_NAME Jackstadt ST:FIRST_NAME Madelyn ST:ADDRESS One Brookings Drive, St. Louis, Missouri, 63130, USA ST:EMAIL mjackstadt@wustl.edu ST:PHONE 3149356405 #SUBJECT SU:SUBJECT_TYPE Fish SU:SUBJECT_SPECIES Danio rerio SU:TAXONOMY_ID 7955 #SUBJECT_SAMPLE_FACTORS: SUBJECT(optional)[tab]SAMPLE[tab]FACTORS(NAME:VALUE pairs separated by |)[tab]Raw file names and additional sample data SUBJECT_SAMPLE_FACTORS - Neg_Anti_1_Brain Treatment:Antimicrobials | Sample source:Brain RAW_FILE_NAME(Raw File Name)=Neg_Anti_1_Brain.mzML SUBJECT_SAMPLE_FACTORS - Neg_Anti_2_Brain Treatment:Antimicrobials | Sample source:Brain RAW_FILE_NAME(Raw File Name)=Neg_Anti_2_Brain.mzML SUBJECT_SAMPLE_FACTORS - Neg_Anti_3_Brain Treatment:Antimicrobials | Sample source:Brain RAW_FILE_NAME(Raw File Name)=Neg_Anti_3_Brain.mzML SUBJECT_SAMPLE_FACTORS - Neg_Anti_4_Brain Treatment:Antimicrobials | Sample source:Brain RAW_FILE_NAME(Raw File Name)=Neg_Anti_4_Brain.mzML SUBJECT_SAMPLE_FACTORS - 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Neg_Anti_5_Intestine Treatment:Antimicrobials | Sample source:Intestine RAW_FILE_NAME(Raw File Name)=Neg_Anti_5_Intestine.mzML SUBJECT_SAMPLE_FACTORS - Neg_Anti_6_Intestine Treatment:Antimicrobials | Sample source:Intestine RAW_FILE_NAME(Raw File Name)=Neg_Anti_6_Intestine.mzML SUBJECT_SAMPLE_FACTORS - Neg_Anti_7_Intestine Treatment:Antimicrobials | Sample source:Intestine RAW_FILE_NAME(Raw File Name)=Neg_Anti_7_Intestine.mzML SUBJECT_SAMPLE_FACTORS - Neg_Anti_8_Intestine Treatment:Antimicrobials | Sample source:Intestine RAW_FILE_NAME(Raw File Name)=Neg_Anti_8_Intestine.mzML SUBJECT_SAMPLE_FACTORS - Neg_Anti_9_Intestine Treatment:Antimicrobials | Sample source:Intestine RAW_FILE_NAME(Raw File Name)=Neg_Anti_9_Intestine.mzML SUBJECT_SAMPLE_FACTORS - Neg_Anti_10_Intestine Treatment:Antimicrobials | Sample source:Intestine RAW_FILE_NAME(Raw File Name)=Neg_Anti_10_Intestine.mzML SUBJECT_SAMPLE_FACTORS - Neg_Ctrl_11_Intestine Treatment:Control | Sample source:Intestine RAW_FILE_NAME(Raw File Name)=Neg_Ctrl_11_Intestine.mzML SUBJECT_SAMPLE_FACTORS - 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Neg_Anti_9_Liver Treatment:Antimicrobials | Sample source:Liver RAW_FILE_NAME(Raw File Name)=Neg_Anti_9_Liver.mzML SUBJECT_SAMPLE_FACTORS - Neg_Anti_10_Liver Treatment:Antimicrobials | Sample source:Liver RAW_FILE_NAME(Raw File Name)=Neg_Anti_10_Liver.mzML SUBJECT_SAMPLE_FACTORS - Neg_Ctrl_11_Liver Treatment:Control | Sample source:Liver RAW_FILE_NAME(Raw File Name)=Neg_Ctrl_11_Liver.mzML SUBJECT_SAMPLE_FACTORS - Neg_Ctrl_12_Liver Treatment:Control | Sample source:Liver RAW_FILE_NAME(Raw File Name)=Neg_Ctrl_12_Liver.mzML SUBJECT_SAMPLE_FACTORS - Neg_Ctrl_13_Liver Treatment:Control | Sample source:Liver RAW_FILE_NAME(Raw File Name)=Neg_Ctrl_13_Liver.mzML SUBJECT_SAMPLE_FACTORS - Neg_Ctrl_14_Liver Treatment:Control | Sample source:Liver RAW_FILE_NAME(Raw File Name)=Neg_Ctrl_14_Liver.mzML SUBJECT_SAMPLE_FACTORS - Neg_Ctrl_15_Liver Treatment:Control | Sample source:Liver RAW_FILE_NAME(Raw File Name)=Neg_Ctrl_15_Liver.mzML SUBJECT_SAMPLE_FACTORS - Neg_Ctrl_17_Liver Treatment:Control | Sample source:Liver RAW_FILE_NAME(Raw File Name)=Neg_Ctrl_17_Liver.mzML SUBJECT_SAMPLE_FACTORS - Neg_Ctrl_18_Liver Treatment:Control | Sample source:Liver RAW_FILE_NAME(Raw File Name)=Neg_Ctrl_18_Liver.mzML SUBJECT_SAMPLE_FACTORS - Neg_Ctrl_19_Liver Treatment:Control | Sample source:Liver RAW_FILE_NAME(Raw File Name)=Neg_Ctrl_19_Liver.mzML SUBJECT_SAMPLE_FACTORS - Neg_Anti_1_Muscle Treatment:Antimicrobials | Sample source:Muscle RAW_FILE_NAME(Raw File Name)=Neg_Anti_1_Muscle.mzML SUBJECT_SAMPLE_FACTORS - Neg_Anti_2_Muscle Treatment:Antimicrobials | Sample source:Muscle RAW_FILE_NAME(Raw File Name)=Neg_Anti_2_Muscle.mzML SUBJECT_SAMPLE_FACTORS - Neg_Anti_3_Muscle Treatment:Antimicrobials | Sample source:Muscle RAW_FILE_NAME(Raw File Name)=Neg_Anti_3_Muscle.mzML SUBJECT_SAMPLE_FACTORS - Neg_Anti_4_Muscle Treatment:Antimicrobials | Sample source:Muscle RAW_FILE_NAME(Raw File Name)=Neg_Anti_4_Muscle.mzML SUBJECT_SAMPLE_FACTORS - Neg_Anti_5_Muscle Treatment:Antimicrobials | Sample source:Muscle RAW_FILE_NAME(Raw File Name)=Neg_Anti_5_Muscle.mzML SUBJECT_SAMPLE_FACTORS - Neg_Anti_6_Muscle Treatment:Antimicrobials | Sample source:Muscle RAW_FILE_NAME(Raw File Name)=Neg_Anti_6_Muscle.mzML SUBJECT_SAMPLE_FACTORS - Neg_Anti_7_Muscle Treatment:Antimicrobials | Sample source:Muscle RAW_FILE_NAME(Raw File Name)=Neg_Anti_7_Muscle.mzML SUBJECT_SAMPLE_FACTORS - Neg_Anti_8_Muscle Treatment:Antimicrobials | Sample source:Muscle RAW_FILE_NAME(Raw File Name)=Neg_Anti_8_Muscle.mzML SUBJECT_SAMPLE_FACTORS - Neg_Anti_9_Muscle Treatment:Antimicrobials | Sample source:Muscle RAW_FILE_NAME(Raw File Name)=Neg_Anti_9_Muscle.mzML SUBJECT_SAMPLE_FACTORS - Neg_Anti_10_Muscle Treatment:Antimicrobials | Sample source:Muscle RAW_FILE_NAME(Raw File Name)=Neg_Anti_10_Muscle.mzML SUBJECT_SAMPLE_FACTORS - Neg_Ctrl_11_Muscle Treatment:Control | Sample source:Muscle RAW_FILE_NAME(Raw File Name)=Neg_Ctrl_11_Muscle.mzML SUBJECT_SAMPLE_FACTORS - Neg_Ctrl_12_Muscle Treatment:Control | Sample source:Muscle RAW_FILE_NAME(Raw File Name)=Neg_Ctrl_12_Muscle.mzML SUBJECT_SAMPLE_FACTORS - Neg_Ctrl_13_Muscle Treatment:Control | Sample source:Muscle RAW_FILE_NAME(Raw File Name)=Neg_Ctrl_13_Muscle.mzML SUBJECT_SAMPLE_FACTORS - Neg_Ctrl_14_Muscle Treatment:Control | Sample source:Muscle RAW_FILE_NAME(Raw File Name)=Neg_Ctrl_14_Muscle.mzML SUBJECT_SAMPLE_FACTORS - Neg_Ctrl_15_Muscle Treatment:Control | Sample source:Muscle RAW_FILE_NAME(Raw File Name)=Neg_Ctrl_15_Muscle.mzML SUBJECT_SAMPLE_FACTORS - Neg_Ctrl_16_Muscle Treatment:Control | Sample source:Muscle RAW_FILE_NAME(Raw File Name)=Neg_Ctrl_16_Muscle.mzML SUBJECT_SAMPLE_FACTORS - Neg_Ctrl_17_Muscle Treatment:Control | Sample source:Muscle RAW_FILE_NAME(Raw File Name)=Neg_Ctrl_17_Muscle.mzML SUBJECT_SAMPLE_FACTORS - Neg_Ctrl_18_Muscle Treatment:Control | Sample source:Muscle RAW_FILE_NAME(Raw File Name)=Neg_Ctrl_18_Muscle.mzML SUBJECT_SAMPLE_FACTORS - Neg_Ctrl_19_Muscle Treatment:Control | Sample source:Muscle RAW_FILE_NAME(Raw File Name)=Neg_Ctrl_19_Muscle.mzML SUBJECT_SAMPLE_FACTORS - Neg_Anti_1_Serum Treatment:Antimicrobials | Sample source:Serum RAW_FILE_NAME(Raw File Name)=Neg_Anti_1_Serum.mzML SUBJECT_SAMPLE_FACTORS - Neg_Anti_2_Serum Treatment:Antimicrobials | Sample source:Serum RAW_FILE_NAME(Raw File Name)=Neg_Anti_2_Serum.mzML SUBJECT_SAMPLE_FACTORS - Neg_Anti_3_Serum Treatment:Antimicrobials | Sample source:Serum RAW_FILE_NAME(Raw File Name)=Neg_Anti_3_Serum.mzML SUBJECT_SAMPLE_FACTORS - Neg_Anti_4_Serum Treatment:Antimicrobials | Sample source:Serum RAW_FILE_NAME(Raw File Name)=Neg_Anti_4_Serum.mzML SUBJECT_SAMPLE_FACTORS - Neg_Anti_5_Serum Treatment:Antimicrobials | Sample source:Serum RAW_FILE_NAME(Raw File Name)=Neg_Anti_5_Serum.mzML SUBJECT_SAMPLE_FACTORS - Neg_Anti_6_Serum Treatment:Antimicrobials | Sample source:Serum RAW_FILE_NAME(Raw File Name)=Neg_Anti_6_Serum.mzML SUBJECT_SAMPLE_FACTORS - Neg_Anti_7_Serum Treatment:Antimicrobials | Sample source:Serum RAW_FILE_NAME(Raw File Name)=Neg_Anti_7_Serum.mzML SUBJECT_SAMPLE_FACTORS - Neg_Anti_8_Serum Treatment:Antimicrobials | Sample source:Serum RAW_FILE_NAME(Raw File Name)=Neg_Anti_8_Serum.mzML SUBJECT_SAMPLE_FACTORS - Neg_Anti_9_Serum Treatment:Antimicrobials | Sample source:Serum RAW_FILE_NAME(Raw File Name)=Neg_Anti_9_Serum.mzML SUBJECT_SAMPLE_FACTORS - Neg_Anti_10_Serum Treatment:Antimicrobials | Sample source:Serum RAW_FILE_NAME(Raw File Name)=Neg_Anti_10_Serum.mzML SUBJECT_SAMPLE_FACTORS - Neg_Ctrl_11_Serum Treatment:Control | Sample source:Serum RAW_FILE_NAME(Raw File Name)=Neg_Ctrl_11_Serum.mzML SUBJECT_SAMPLE_FACTORS - Neg_Ctrl_12_Serum Treatment:Control | Sample source:Serum RAW_FILE_NAME(Raw File Name)=Neg_Ctrl_12_Serum.mzML SUBJECT_SAMPLE_FACTORS - Neg_Ctrl_13_Serum Treatment:Control | Sample source:Serum RAW_FILE_NAME(Raw File Name)=Neg_Ctrl_13_Serum.mzML SUBJECT_SAMPLE_FACTORS - Neg_Ctrl_14_Serum Treatment:Control | Sample source:Serum RAW_FILE_NAME(Raw File Name)=Neg_Ctrl_14_Serum.mzML SUBJECT_SAMPLE_FACTORS - Neg_Ctrl_15_Serum Treatment:Control | Sample source:Serum RAW_FILE_NAME(Raw File Name)=Neg_Ctrl_15_Serum.mzML SUBJECT_SAMPLE_FACTORS - Neg_Ctrl_16_Serum Treatment:Control | Sample source:Serum RAW_FILE_NAME(Raw File Name)=Neg_Ctrl_16_Serum.mzML SUBJECT_SAMPLE_FACTORS - Neg_Ctrl_18_Serum Treatment:Control | Sample source:Serum RAW_FILE_NAME(Raw File Name)=Neg_Ctrl_18_Serum.mzML SUBJECT_SAMPLE_FACTORS - Neg_Ctrl_19_Serum Treatment:Control | Sample source:Serum RAW_FILE_NAME(Raw File Name)=Neg_Ctrl_19_Serum.mzML SUBJECT_SAMPLE_FACTORS - Pos_Anti_1_Brain Treatment:Antimicrobials | Sample source:Brain RAW_FILE_NAME(Raw File Name)=Pos_Anti_1_Brain.mzML SUBJECT_SAMPLE_FACTORS - Pos_Anti_2_Brain Treatment:Antimicrobials | Sample source:Brain RAW_FILE_NAME(Raw File Name)=Pos_Anti_2_Brain.mzML SUBJECT_SAMPLE_FACTORS - Pos_Anti_3_Brain Treatment:Antimicrobials | Sample source:Brain RAW_FILE_NAME(Raw File Name)=Pos_Anti_3_Brain.mzML SUBJECT_SAMPLE_FACTORS - Pos_Anti_4_Brain Treatment:Antimicrobials | Sample source:Brain RAW_FILE_NAME(Raw File Name)=Pos_Anti_4_Brain.mzML SUBJECT_SAMPLE_FACTORS - Pos_Anti_5_Brain Treatment:Antimicrobials | Sample source:Brain RAW_FILE_NAME(Raw File Name)=Pos_Anti_5_Brain.mzML SUBJECT_SAMPLE_FACTORS - Pos_Anti_6_Brain Treatment:Antimicrobials | Sample source:Brain RAW_FILE_NAME(Raw File Name)=Pos_Anti_6_Brain.mzML SUBJECT_SAMPLE_FACTORS - Pos_Anti_7_Brain Treatment:Antimicrobials | Sample source:Brain RAW_FILE_NAME(Raw File Name)=Pos_Anti_7_Brain.mzML SUBJECT_SAMPLE_FACTORS - Pos_Anti_8_Brain Treatment:Antimicrobials | Sample source:Brain RAW_FILE_NAME(Raw File Name)=Pos_Anti_8_Brain.mzML SUBJECT_SAMPLE_FACTORS - Pos_Anti_9_Brain Treatment:Antimicrobials | Sample source:Brain RAW_FILE_NAME(Raw File Name)=Pos_Anti_9_Brain.mzML SUBJECT_SAMPLE_FACTORS - Pos_Anti_10_Brain Treatment:Antimicrobials | Sample source:Brain RAW_FILE_NAME(Raw File Name)=Pos_Anti_10_Brain.mzML SUBJECT_SAMPLE_FACTORS - Pos_Ctrl_11_Brain Treatment:Control | Sample source:Brain RAW_FILE_NAME(Raw File Name)=Pos_Ctrl_11_Brain.mzML SUBJECT_SAMPLE_FACTORS - Pos_Ctrl_13_Brain Treatment:Control | Sample source:Brain RAW_FILE_NAME(Raw File Name)=Pos_Ctrl_13_Brain.mzML SUBJECT_SAMPLE_FACTORS - Pos_Ctrl_14_Brain Treatment:Control | Sample source:Brain RAW_FILE_NAME(Raw File Name)=Pos_Ctrl_14_Brain.mzML SUBJECT_SAMPLE_FACTORS - Pos_Ctrl_15_Brain Treatment:Control | Sample source:Brain RAW_FILE_NAME(Raw File Name)=Pos_Ctrl_15_Brain.mzML SUBJECT_SAMPLE_FACTORS - Pos_Ctrl_16_Brain Treatment:Control | Sample source:Brain RAW_FILE_NAME(Raw File Name)=Pos_Ctrl_16_Brain.mzML SUBJECT_SAMPLE_FACTORS - Pos_Ctrl_17_Brain Treatment:Control | Sample source:Brain RAW_FILE_NAME(Raw File Name)=Pos_Ctrl_17_Brain.mzML SUBJECT_SAMPLE_FACTORS - Pos_Ctrl_18_Brain Treatment:Control | Sample source:Brain RAW_FILE_NAME(Raw File Name)=Pos_Ctrl_18_Brain.mzML SUBJECT_SAMPLE_FACTORS - Pos_Ctrl_19_Brain Treatment:Control | Sample source:Brain RAW_FILE_NAME(Raw File Name)=Pos_Ctrl_19_Brain.mzML SUBJECT_SAMPLE_FACTORS - Pos_Anti_1_Eye Treatment:Antimicrobials | Sample source:Eye RAW_FILE_NAME(Raw File Name)=Pos_Anti_1_Eye.mzML SUBJECT_SAMPLE_FACTORS - Pos_Anti_2_Eye Treatment:Antimicrobials | Sample source:Eye RAW_FILE_NAME(Raw File Name)=Pos_Anti_2_Eye.mzML SUBJECT_SAMPLE_FACTORS - Pos_Anti_3_Eye Treatment:Antimicrobials | Sample source:Eye RAW_FILE_NAME(Raw File Name)=Pos_Anti_3_Eye.mzML SUBJECT_SAMPLE_FACTORS - Pos_Anti_4_Eye Treatment:Antimicrobials | Sample source:Eye RAW_FILE_NAME(Raw File Name)=Pos_Anti_4_Eye.mzML SUBJECT_SAMPLE_FACTORS - Pos_Anti_5_Eye Treatment:Antimicrobials | Sample source:Eye RAW_FILE_NAME(Raw File Name)=Pos_Anti_5_Eye.mzML SUBJECT_SAMPLE_FACTORS - Pos_Anti_6_Eye Treatment:Antimicrobials | Sample source:Eye RAW_FILE_NAME(Raw File Name)=Pos_Anti_6_Eye.mzML SUBJECT_SAMPLE_FACTORS - Pos_Anti_7_Eye Treatment:Antimicrobials | Sample source:Eye RAW_FILE_NAME(Raw File Name)=Pos_Anti_7_Eye.mzML SUBJECT_SAMPLE_FACTORS - Pos_Anti_8_Eye Treatment:Antimicrobials | Sample source:Eye RAW_FILE_NAME(Raw File Name)=Pos_Anti_8_Eye.mzML SUBJECT_SAMPLE_FACTORS - Pos_Anti_9_Eye Treatment:Antimicrobials | Sample source:Eye RAW_FILE_NAME(Raw File Name)=Pos_Anti_9_Eye.mzML SUBJECT_SAMPLE_FACTORS - Pos_Anti_10_Eye Treatment:Antimicrobials | Sample source:Eye RAW_FILE_NAME(Raw File Name)=Pos_Anti_10_Eye.mzML SUBJECT_SAMPLE_FACTORS - Pos_Ctrl_11_Eye Treatment:Control | Sample source:Eye RAW_FILE_NAME(Raw File Name)=Pos_Ctrl_11_Eye.mzML SUBJECT_SAMPLE_FACTORS - Pos_Ctrl_12_Eye Treatment:Control | Sample source:Eye RAW_FILE_NAME(Raw File Name)=Pos_Ctrl_12_Eye.mzML SUBJECT_SAMPLE_FACTORS - Pos_Ctrl_13_Eye Treatment:Control | Sample source:Eye RAW_FILE_NAME(Raw File Name)=Pos_Ctrl_13_Eye.mzML SUBJECT_SAMPLE_FACTORS - Pos_Ctrl_14_Eye Treatment:Control | Sample source:Eye RAW_FILE_NAME(Raw File Name)=Pos_Ctrl_14_Eye.mzML SUBJECT_SAMPLE_FACTORS - Pos_Ctrl_15_Eye Treatment:Control | Sample source:Eye RAW_FILE_NAME(Raw File Name)=Pos_Ctrl_15_Eye.mzML SUBJECT_SAMPLE_FACTORS - Pos_Ctrl_16_Eye Treatment:Control | Sample source:Eye RAW_FILE_NAME(Raw File Name)=Pos_Ctrl_16_Eye.mzML SUBJECT_SAMPLE_FACTORS - Pos_Ctrl_17_Eye Treatment:Control | Sample source:Eye RAW_FILE_NAME(Raw File Name)=Pos_Ctrl_17_Eye.mzML SUBJECT_SAMPLE_FACTORS - Pos_Ctrl_18_Eye Treatment:Control | Sample source:Eye RAW_FILE_NAME(Raw File Name)=Pos_Ctrl_18_Eye.mzML SUBJECT_SAMPLE_FACTORS - Pos_Anti_1_Fin Treatment:Antimicrobials | Sample source:Fin RAW_FILE_NAME(Raw File Name)=Pos_Anti_1_Fin.mzML SUBJECT_SAMPLE_FACTORS - Pos_Anti_2_Fin Treatment:Antimicrobials | Sample source:Fin RAW_FILE_NAME(Raw File Name)=Pos_Anti_2_Fin.mzML SUBJECT_SAMPLE_FACTORS - Pos_Anti_3_Fin Treatment:Antimicrobials | Sample source:Fin RAW_FILE_NAME(Raw File Name)=Pos_Anti_3_Fin.mzML SUBJECT_SAMPLE_FACTORS - Pos_Anti_4_Fin Treatment:Antimicrobials | Sample source:Fin RAW_FILE_NAME(Raw File Name)=Pos_Anti_4_Fin.mzML SUBJECT_SAMPLE_FACTORS - Pos_Anti_5_Fin Treatment:Antimicrobials | Sample source:Fin RAW_FILE_NAME(Raw File Name)=Pos_Anti_5_Fin.mzML SUBJECT_SAMPLE_FACTORS - Pos_Anti_6_Fin Treatment:Antimicrobials | Sample source:Fin RAW_FILE_NAME(Raw File Name)=Pos_Anti_6_Fin.mzML SUBJECT_SAMPLE_FACTORS - Pos_Anti_7_Fin Treatment:Antimicrobials | Sample source:Fin RAW_FILE_NAME(Raw File Name)=Pos_Anti_7_Fin.mzML SUBJECT_SAMPLE_FACTORS - Pos_Anti_8_Fin Treatment:Antimicrobials | Sample source:Fin RAW_FILE_NAME(Raw File Name)=Pos_Anti_8_Fin.mzML SUBJECT_SAMPLE_FACTORS - Pos_Anti_9_Fin Treatment:Antimicrobials | Sample source:Fin RAW_FILE_NAME(Raw File Name)=Pos_Anti_9_Fin.mzML SUBJECT_SAMPLE_FACTORS - Pos_Anti_10_Fin Treatment:Antimicrobials | Sample source:Fin RAW_FILE_NAME(Raw File Name)=Pos_Anti_10_Fin.mzML SUBJECT_SAMPLE_FACTORS - Pos_Ctrl_11_Fin Treatment:Control | Sample source:Fin RAW_FILE_NAME(Raw File Name)=Pos_Ctrl_11_Fin.mzML SUBJECT_SAMPLE_FACTORS - Pos_Ctrl_12_Fin Treatment:Control | Sample source:Fin RAW_FILE_NAME(Raw File Name)=Pos_Ctrl_12_Fin.mzML SUBJECT_SAMPLE_FACTORS - Pos_Ctrl_13_Fin Treatment:Control | Sample source:Fin RAW_FILE_NAME(Raw File Name)=Pos_Ctrl_13_Fin.mzML SUBJECT_SAMPLE_FACTORS - Pos_Ctrl_14_Fin Treatment:Control | Sample source:Fin RAW_FILE_NAME(Raw File Name)=Pos_Ctrl_14_Fin.mzML SUBJECT_SAMPLE_FACTORS - Pos_Ctrl_15_Fin Treatment:Control | Sample source:Fin RAW_FILE_NAME(Raw File Name)=Pos_Ctrl_15_Fin.mzML SUBJECT_SAMPLE_FACTORS - Pos_Ctrl_16_Fin Treatment:Control | Sample source:Fin RAW_FILE_NAME(Raw File Name)=Pos_Ctrl_16_Fin.mzML SUBJECT_SAMPLE_FACTORS - Pos_Ctrl_17_Fin Treatment:Control | Sample source:Fin RAW_FILE_NAME(Raw File Name)=Pos_Ctrl_17_Fin.mzML SUBJECT_SAMPLE_FACTORS - Pos_Ctrl_18_Fin Treatment:Control | Sample source:Fin RAW_FILE_NAME(Raw File Name)=Pos_Ctrl_18_Fin.mzML SUBJECT_SAMPLE_FACTORS - Pos_Ctrl_19_Fin Treatment:Control | Sample source:Fin RAW_FILE_NAME(Raw File Name)=Pos_Ctrl_19_Fin.mzML SUBJECT_SAMPLE_FACTORS - Pos_Anti_1_Heart Treatment:Antimicrobials | Sample source:Heart RAW_FILE_NAME(Raw File Name)=Pos_Anti_1_Heart.mzML SUBJECT_SAMPLE_FACTORS - Pos_Anti_2_Heart Treatment:Antimicrobials | Sample source:Heart RAW_FILE_NAME(Raw File Name)=Pos_Anti_2_Heart.mzML SUBJECT_SAMPLE_FACTORS - Pos_Anti_3_Heart Treatment:Antimicrobials | Sample source:Heart RAW_FILE_NAME(Raw File Name)=Pos_Anti_3_Heart.mzML SUBJECT_SAMPLE_FACTORS - Pos_Anti_4_Heart Treatment:Antimicrobials | Sample source:Heart RAW_FILE_NAME(Raw File Name)=Pos_Anti_4_Heart.mzML SUBJECT_SAMPLE_FACTORS - Pos_Anti_5_Heart Treatment:Antimicrobials | Sample source:Heart RAW_FILE_NAME(Raw File Name)=Pos_Anti_5_Heart.mzML SUBJECT_SAMPLE_FACTORS - Pos_Anti_6_Heart Treatment:Antimicrobials | Sample source:Heart RAW_FILE_NAME(Raw File Name)=Pos_Anti_6_Heart.mzML SUBJECT_SAMPLE_FACTORS - Pos_Anti_7_Heart Treatment:Antimicrobials | Sample source:Heart RAW_FILE_NAME(Raw File Name)=Pos_Anti_7_Heart.mzML SUBJECT_SAMPLE_FACTORS - Pos_Anti_8_Heart Treatment:Antimicrobials | Sample source:Heart RAW_FILE_NAME(Raw File Name)=Pos_Anti_8_Heart.mzML SUBJECT_SAMPLE_FACTORS - Pos_Anti_9_Heart Treatment:Antimicrobials | Sample source:Heart RAW_FILE_NAME(Raw File Name)=Pos_Anti_9_Heart.mzML SUBJECT_SAMPLE_FACTORS - Pos_Anti_10_Heart Treatment:Antimicrobials | Sample source:Heart RAW_FILE_NAME(Raw File Name)=Pos_Anti_10_Heart.mzML SUBJECT_SAMPLE_FACTORS - Pos_Ctrl_11_Heart Treatment:Control | Sample source:Heart RAW_FILE_NAME(Raw File Name)=Pos_Ctrl_11_Heart.mzML SUBJECT_SAMPLE_FACTORS - Pos_Ctrl_12_Heart Treatment:Control | Sample source:Heart RAW_FILE_NAME(Raw File Name)=Pos_Ctrl_12_Heart.mzML SUBJECT_SAMPLE_FACTORS - Pos_Ctrl_13_Heart Treatment:Control | Sample source:Heart RAW_FILE_NAME(Raw File Name)=Pos_Ctrl_13_Heart.mzML SUBJECT_SAMPLE_FACTORS - Pos_Ctrl_14_Heart Treatment:Control | Sample source:Heart RAW_FILE_NAME(Raw File Name)=Pos_Ctrl_14_Heart.mzML SUBJECT_SAMPLE_FACTORS - Pos_Ctrl_15_Heart Treatment:Control | Sample source:Heart RAW_FILE_NAME(Raw File Name)=Pos_Ctrl_15_Heart.mzML SUBJECT_SAMPLE_FACTORS - Pos_Ctrl_16_Heart Treatment:Control | Sample source:Heart RAW_FILE_NAME(Raw File Name)=Pos_Ctrl_16_Heart.mzML SUBJECT_SAMPLE_FACTORS - Pos_Ctrl_19_Heart Treatment:Control | Sample source:Heart RAW_FILE_NAME(Raw File Name)=Pos_Ctrl_19_Heart.mzML SUBJECT_SAMPLE_FACTORS - Pos_Anti_1_Intestine Treatment:Antimicrobials | Sample source:Intestine RAW_FILE_NAME(Raw File Name)=Pos_Anti_1_Intestine.mzML SUBJECT_SAMPLE_FACTORS - Pos_Anti_2_Intestine Treatment:Antimicrobials | Sample source:Intestine RAW_FILE_NAME(Raw File Name)=Pos_Anti_2_Intestine.mzML SUBJECT_SAMPLE_FACTORS - Pos_Anti_3_Intestine Treatment:Antimicrobials | Sample source:Intestine RAW_FILE_NAME(Raw File Name)=Pos_Anti_3_Intestine.mzML SUBJECT_SAMPLE_FACTORS - Pos_Anti_4_Intestine Treatment:Antimicrobials | Sample source:Intestine RAW_FILE_NAME(Raw File Name)=Pos_Anti_4_Intestine.mzML SUBJECT_SAMPLE_FACTORS - Pos_Anti_5_Intestine Treatment:Antimicrobials | Sample source:Intestine RAW_FILE_NAME(Raw File Name)=Pos_Anti_5_Intestine.mzML SUBJECT_SAMPLE_FACTORS - Pos_Anti_6_Intestine Treatment:Antimicrobials | Sample source:Intestine RAW_FILE_NAME(Raw File Name)=Pos_Anti_6_Intestine.mzML SUBJECT_SAMPLE_FACTORS - Pos_Anti_7_Intestine Treatment:Antimicrobials | Sample source:Intestine RAW_FILE_NAME(Raw File Name)=Pos_Anti_7_Intestine.mzML SUBJECT_SAMPLE_FACTORS - Pos_Anti_8_Intestine Treatment:Antimicrobials | Sample source:Intestine RAW_FILE_NAME(Raw File Name)=Pos_Anti_8_Intestine.mzML SUBJECT_SAMPLE_FACTORS - Pos_Anti_9_Intestine Treatment:Antimicrobials | Sample source:Intestine RAW_FILE_NAME(Raw File Name)=Pos_Anti_9_Intestine.mzML SUBJECT_SAMPLE_FACTORS - Pos_Anti_10_Intestine Treatment:Antimicrobials | Sample source:Intestine RAW_FILE_NAME(Raw File Name)=Pos_Anti_10_Intestine.mzML SUBJECT_SAMPLE_FACTORS - Pos_Ctrl_11_Intestine Treatment:Control | Sample source:Intestine RAW_FILE_NAME(Raw File Name)=Pos_Ctrl_11_Intestine.mzML SUBJECT_SAMPLE_FACTORS - Pos_Ctrl_12_Intestine Treatment:Control | Sample source:Intestine RAW_FILE_NAME(Raw File Name)=Pos_Ctrl_12_Intestine.mzML SUBJECT_SAMPLE_FACTORS - Pos_Ctrl_13_Intestine Treatment:Control | Sample source:Intestine RAW_FILE_NAME(Raw File Name)=Pos_Ctrl_13_Intestine.mzML SUBJECT_SAMPLE_FACTORS - Pos_Ctrl_14_Intestine Treatment:Control | Sample source:Intestine RAW_FILE_NAME(Raw File Name)=Pos_Ctrl_14_Intestine.mzML SUBJECT_SAMPLE_FACTORS - Pos_Ctrl_15_Intestine Treatment:Control | Sample source:Intestine RAW_FILE_NAME(Raw File Name)=Pos_Ctrl_15_Intestine.mzML SUBJECT_SAMPLE_FACTORS - Pos_Ctrl_16_Intestine Treatment:Control | Sample source:Intestine RAW_FILE_NAME(Raw File Name)=Pos_Ctrl_16_Intestine.mzML SUBJECT_SAMPLE_FACTORS - Pos_Ctrl_17_Intestine Treatment:Control | Sample source:Intestine RAW_FILE_NAME(Raw File Name)=Pos_Ctrl_17_Intestine.mzML SUBJECT_SAMPLE_FACTORS - Pos_Ctrl_19_Intestine Treatment:Control | Sample source:Intestine RAW_FILE_NAME(Raw File Name)=Pos_Ctrl_19_Intestine.mzML SUBJECT_SAMPLE_FACTORS - Pos_Anti_1_Liver Treatment:Antimicrobials | Sample source:Liver RAW_FILE_NAME(Raw File Name)=Pos_Anti_1_Liver.mzML SUBJECT_SAMPLE_FACTORS - Pos_Anti_2_Liver Treatment:Antimicrobials | Sample source:Liver RAW_FILE_NAME(Raw File Name)=Pos_Anti_2_Liver.mzML SUBJECT_SAMPLE_FACTORS - Pos_Anti_3_Liver Treatment:Antimicrobials | Sample source:Liver RAW_FILE_NAME(Raw File Name)=Pos_Anti_3_Liver.mzML SUBJECT_SAMPLE_FACTORS - Pos_Anti_4_Liver Treatment:Antimicrobials | Sample source:Liver RAW_FILE_NAME(Raw File Name)=Pos_Anti_4_Liver.mzML SUBJECT_SAMPLE_FACTORS - Pos_Anti_5_Liver Treatment:Antimicrobials | Sample source:Liver RAW_FILE_NAME(Raw File Name)=Pos_Anti_5_Liver.mzML SUBJECT_SAMPLE_FACTORS - Pos_Anti_6_Liver Treatment:Antimicrobials | Sample source:Liver RAW_FILE_NAME(Raw File Name)=Pos_Anti_6_Liver.mzML SUBJECT_SAMPLE_FACTORS - Pos_Anti_7_Liver Treatment:Antimicrobials | Sample source:Liver RAW_FILE_NAME(Raw File Name)=Pos_Anti_7_Liver.mzML SUBJECT_SAMPLE_FACTORS - Pos_Anti_8_Liver Treatment:Antimicrobials | Sample source:Liver RAW_FILE_NAME(Raw File Name)=Pos_Anti_8_Liver.mzML SUBJECT_SAMPLE_FACTORS - Pos_Anti_9_Liver Treatment:Antimicrobials | Sample source:Liver RAW_FILE_NAME(Raw File Name)=Pos_Anti_9_Liver.mzML SUBJECT_SAMPLE_FACTORS - Pos_Anti_10_Liver Treatment:Antimicrobials | Sample source:Liver RAW_FILE_NAME(Raw File Name)=Pos_Anti_10_Liver.mzML SUBJECT_SAMPLE_FACTORS - Pos_Ctrl_11_Liver Treatment:Control | Sample source:Liver RAW_FILE_NAME(Raw File Name)=Pos_Ctrl_11_Liver.mzML SUBJECT_SAMPLE_FACTORS - Pos_Ctrl_12_Liver Treatment:Control | Sample source:Liver RAW_FILE_NAME(Raw File Name)=Pos_Ctrl_12_Liver.mzML SUBJECT_SAMPLE_FACTORS - Pos_Ctrl_13_Liver Treatment:Control | Sample source:Liver RAW_FILE_NAME(Raw File Name)=Pos_Ctrl_13_Liver.mzML SUBJECT_SAMPLE_FACTORS - Pos_Ctrl_14_Liver Treatment:Control | Sample source:Liver RAW_FILE_NAME(Raw File Name)=Pos_Ctrl_14_Liver.mzML SUBJECT_SAMPLE_FACTORS - Pos_Ctrl_15_Liver Treatment:Control | Sample source:Liver RAW_FILE_NAME(Raw File Name)=Pos_Ctrl_15_Liver.mzML SUBJECT_SAMPLE_FACTORS - Pos_Ctrl_17_Liver Treatment:Control | Sample source:Liver RAW_FILE_NAME(Raw File Name)=Pos_Ctrl_17_Liver.mzML SUBJECT_SAMPLE_FACTORS - Pos_Ctrl_18_Liver Treatment:Control | Sample source:Liver RAW_FILE_NAME(Raw File Name)=Pos_Ctrl_18_Liver.mzML SUBJECT_SAMPLE_FACTORS - Pos_Ctrl_19_Liver Treatment:Control | Sample source:Liver RAW_FILE_NAME(Raw File Name)=Pos_Ctrl_19_Liver.mzML SUBJECT_SAMPLE_FACTORS - Pos_Anti_1_Muscle Treatment:Antimicrobials | Sample source:Muscle RAW_FILE_NAME(Raw File Name)=Pos_Anti_1_Muscle.mzML SUBJECT_SAMPLE_FACTORS - Pos_Anti_2_Muscle Treatment:Antimicrobials | Sample source:Muscle RAW_FILE_NAME(Raw File Name)=Pos_Anti_2_Muscle.mzML SUBJECT_SAMPLE_FACTORS - Pos_Anti_3_Muscle Treatment:Antimicrobials | Sample source:Muscle RAW_FILE_NAME(Raw File Name)=Pos_Anti_3_Muscle.mzML SUBJECT_SAMPLE_FACTORS - Pos_Anti_4_Muscle Treatment:Antimicrobials | Sample source:Muscle RAW_FILE_NAME(Raw File Name)=Pos_Anti_4_Muscle.mzML SUBJECT_SAMPLE_FACTORS - Pos_Anti_5_Muscle Treatment:Antimicrobials | Sample source:Muscle RAW_FILE_NAME(Raw File Name)=Pos_Anti_5_Muscle.mzML SUBJECT_SAMPLE_FACTORS - Pos_Anti_6_Muscle Treatment:Antimicrobials | Sample source:Muscle RAW_FILE_NAME(Raw File Name)=Pos_Anti_6_Muscle.mzML SUBJECT_SAMPLE_FACTORS - Pos_Anti_7_Muscle Treatment:Antimicrobials | Sample source:Muscle RAW_FILE_NAME(Raw File Name)=Pos_Anti_7_Muscle.mzML SUBJECT_SAMPLE_FACTORS - Pos_Anti_8_Muscle Treatment:Antimicrobials | Sample source:Muscle RAW_FILE_NAME(Raw File Name)=Pos_Anti_8_Muscle.mzML SUBJECT_SAMPLE_FACTORS - Pos_Anti_9_Muscle Treatment:Antimicrobials | Sample source:Muscle RAW_FILE_NAME(Raw File Name)=Pos_Anti_9_Muscle.mzML SUBJECT_SAMPLE_FACTORS - Pos_Anti_10_Muscle Treatment:Antimicrobials | Sample source:Muscle RAW_FILE_NAME(Raw File Name)=Pos_Anti_10_Muscle.mzML SUBJECT_SAMPLE_FACTORS - Pos_Ctrl_11_Muscle Treatment:Control | Sample source:Muscle RAW_FILE_NAME(Raw File Name)=Pos_Ctrl_11_Muscle.mzML SUBJECT_SAMPLE_FACTORS - Pos_Ctrl_12_Muscle Treatment:Control | Sample source:Muscle RAW_FILE_NAME(Raw File Name)=Pos_Ctrl_12_Muscle.mzML SUBJECT_SAMPLE_FACTORS - Pos_Ctrl_13_Muscle Treatment:Control | Sample source:Muscle RAW_FILE_NAME(Raw File Name)=Pos_Ctrl_13_Muscle.mzML SUBJECT_SAMPLE_FACTORS - Pos_Ctrl_14_Muscle Treatment:Control | Sample source:Muscle RAW_FILE_NAME(Raw File Name)=Pos_Ctrl_14_Muscle.mzML SUBJECT_SAMPLE_FACTORS - Pos_Ctrl_15_Muscle Treatment:Control | Sample source:Muscle RAW_FILE_NAME(Raw File Name)=Pos_Ctrl_15_Muscle.mzML SUBJECT_SAMPLE_FACTORS - Pos_Ctrl_16_Muscle Treatment:Control | Sample source:Muscle RAW_FILE_NAME(Raw File Name)=Pos_Ctrl_16_Muscle.mzML SUBJECT_SAMPLE_FACTORS - Pos_Ctrl_17_Muscle Treatment:Control | Sample source:Muscle RAW_FILE_NAME(Raw File Name)=Pos_Ctrl_17_Muscle.mzML SUBJECT_SAMPLE_FACTORS - Pos_Ctrl_18_Muscle Treatment:Control | Sample source:Muscle RAW_FILE_NAME(Raw File Name)=Pos_Ctrl_18_Muscle.mzML SUBJECT_SAMPLE_FACTORS - Pos_Ctrl_19_Muscle Treatment:Control | Sample source:Muscle RAW_FILE_NAME(Raw File Name)=Pos_Ctrl_19_Muscle.mzML SUBJECT_SAMPLE_FACTORS - Pos_Anti_1_Serum Treatment:Antimicrobials | Sample source:Serum RAW_FILE_NAME(Raw File Name)=Pos_Anti_1_Serum.mzML SUBJECT_SAMPLE_FACTORS - Pos_Anti_2_Serum Treatment:Antimicrobials | Sample source:Serum RAW_FILE_NAME(Raw File Name)=Pos_Anti_2_Serum.mzML SUBJECT_SAMPLE_FACTORS - Pos_Anti_4_Serum Treatment:Antimicrobials | Sample source:Serum RAW_FILE_NAME(Raw File Name)=Pos_Anti_4_Serum.mzML SUBJECT_SAMPLE_FACTORS - Pos_Anti_5_Serum Treatment:Antimicrobials | Sample source:Serum RAW_FILE_NAME(Raw File Name)=Pos_Anti_5_Serum.mzML SUBJECT_SAMPLE_FACTORS - Pos_Anti_6_Serum Treatment:Antimicrobials | Sample source:Serum RAW_FILE_NAME(Raw File Name)=Pos_Anti_6_Serum.mzML SUBJECT_SAMPLE_FACTORS - Pos_Anti_7_Serum Treatment:Antimicrobials | Sample source:Serum RAW_FILE_NAME(Raw File Name)=Pos_Anti_7_Serum.mzML SUBJECT_SAMPLE_FACTORS - Pos_Anti_8_Serum Treatment:Antimicrobials | Sample source:Serum RAW_FILE_NAME(Raw File Name)=Pos_Anti_8_Serum.mzML SUBJECT_SAMPLE_FACTORS - Pos_Anti_9_Serum Treatment:Antimicrobials | Sample source:Serum RAW_FILE_NAME(Raw File Name)=Pos_Anti_9_Serum.mzML SUBJECT_SAMPLE_FACTORS - Pos_Anti_10_Serum Treatment:Antimicrobials | Sample source:Serum RAW_FILE_NAME(Raw File Name)=Pos_Anti_10_Serum.mzML SUBJECT_SAMPLE_FACTORS - Pos_Ctrl_11_Serum Treatment:Control | Sample source:Serum RAW_FILE_NAME(Raw File Name)=Pos_Ctrl_11_Serum.mzML SUBJECT_SAMPLE_FACTORS - Pos_Ctrl_12_Serum Treatment:Control | Sample source:Serum RAW_FILE_NAME(Raw File Name)=Pos_Ctrl_12_Serum.mzML SUBJECT_SAMPLE_FACTORS - Pos_Ctrl_13_Serum Treatment:Control | Sample source:Serum RAW_FILE_NAME(Raw File Name)=Pos_Ctrl_13_Serum.mzML SUBJECT_SAMPLE_FACTORS - Pos_Ctrl_15_Serum Treatment:Control | Sample source:Serum RAW_FILE_NAME(Raw File Name)=Pos_Ctrl_15_Serum.mzML SUBJECT_SAMPLE_FACTORS - Pos_Ctrl_16_Serum Treatment:Control | Sample source:Serum RAW_FILE_NAME(Raw File Name)=Pos_Ctrl_16_Serum.mzML SUBJECT_SAMPLE_FACTORS - Pos_Ctrl_18_Serum Treatment:Control | Sample source:Serum RAW_FILE_NAME(Raw File Name)=Pos_Ctrl_18_Serum.mzML SUBJECT_SAMPLE_FACTORS - Pos_Ctrl_19_Serum Treatment:Control | Sample source:Serum RAW_FILE_NAME(Raw File Name)=Pos_Ctrl_19_Serum.mzML #COLLECTION CO:COLLECTION_SUMMARY Zebrafish were anesthetized and thoroughly dried before a scalpel was used to CO:COLLECTION_SUMMARY excise the caudal fin and some attached muscle tissue. Zebrafish were then CO:COLLECTION_SUMMARY immediately placed in a spin column such that blood from the wound could flow CO:COLLECTION_SUMMARY from the fish (in a 1.5 mL microcentrifuge tube with a small hole in the bottom) CO:COLLECTION_SUMMARY to a collection tube (a 0.5 mL microcentrifuge tube) during a brief, low-speed CO:COLLECTION_SUMMARY centrifugation (40 g for 1 min at 15 C). Immediately following blood collection, CO:COLLECTION_SUMMARY whole blood was placed on ice for 10 min while organs were harvested in CO:COLLECTION_SUMMARY pre-weighed microcentrifuge tubes and snap frozen in liquid nitrogen. After CO:COLLECTION_SUMMARY clotting on ice, whole blood was centrifuged at 1600 g for 10 min at 4 C. Serum CO:COLLECTION_SUMMARY (top layer) was then pipetted into a new 0.5 mL microcentrifuge tube and snap CO:COLLECTION_SUMMARY frozen in liquid nitrogen. CO:SAMPLE_TYPE brain, eye, fin, heart, intestine, liver, muscle, serum #TREATMENT TR:TREATMENT_SUMMARY For control treatment, conditioned facility water was autoclaved prior to TR:TREATMENT_SUMMARY zebrafish exposure. For antimicrobial treatment, 2% penicillin/streptomycin, 5 TR:TREATMENT_SUMMARY ug/mL kanamycin, 100 ug/mL ampicillin, and 250 ng/mL amphotericin b were added TR:TREATMENT_SUMMARY to autoclaved facility water. #SAMPLEPREP SP:SAMPLEPREP_SUMMARY For serum extractions, samples were stored on ice until the addition of 2:2:1 SP:SAMPLEPREP_SUMMARY methanol:acetonitrile:water (MAW) at a ratio of 1 uL serum:15 uL MAW. Samples SP:SAMPLEPREP_SUMMARY were briefly mixed and immediately placed at -20 C for 1 h. Following SP:SAMPLEPREP_SUMMARY incubation, samples were centrifuged at 20,000 g for 10 min at 4 C, and SP:SAMPLEPREP_SUMMARY supernatant was transferred to LC-MS vials for analysis. For organ samples, SP:SAMPLEPREP_SUMMARY tissues were ground in collection tubes by using a pestle while submerged in SP:SAMPLEPREP_SUMMARY liquid nitrogen. Frozen samples in tubes were then massed, and the preweight of SP:SAMPLEPREP_SUMMARY the tube was subtracted to yield tissue weight. 40 uL of 2:2:1 MAW were added SP:SAMPLEPREP_SUMMARY per mg wet tissue weight, and the sample was vortexed before snap freezing in SP:SAMPLEPREP_SUMMARY liquid nitrogen. Simultaneously, samples were extracted by thawing in room SP:SAMPLEPREP_SUMMARY temperature water (~10 s), sonicating (5 min), vortexing (~30 s), snap freezing SP:SAMPLEPREP_SUMMARY in liquid nitrogen (~1 min), thawing in room temperature water (~10 s), SP:SAMPLEPREP_SUMMARY sonicating (5 min), and vortexing (~30 s) before incubating at -20 C for 1 h. SP:SAMPLEPREP_SUMMARY Following incubation, samples were centrifuged at 20,000 g for 10 min at 4 C, SP:SAMPLEPREP_SUMMARY and supernatant was transferred to LC-MS vials for analysis. #CHROMATOGRAPHY CH:CHROMATOGRAPHY_TYPE HILIC CH:INSTRUMENT_NAME Thermo Dionex CH:COLUMN_NAME HILICON iHILIC-(P) Classic (100 x 2.1mm,5um) CH:SOLVENT_A 95% water/5% acetonitrile; 20 mM ammonium bicarbonate; 0.1% ammonium hydroxide; CH:SOLVENT_A 2.5 μM medronic acid CH:SOLVENT_B 95% acetonitrile/5% water; 2.5 μM medronic acid CH:FLOW_GRADIENT 0-1 min, 90% solvent B at 250 μL/min; 1-13 min, linear gradient from 90% CH:FLOW_GRADIENT solvent B to 30% solvent B at 250 μL/min; 13-14 min, held at 30% solvent B at CH:FLOW_GRADIENT 250 μL/min; 14-14.5 min, 30% solvent B at 150 μL/min; 14.5-15 min, 10% solvent CH:FLOW_GRADIENT B at 150 μL/min; 15-17 min, held at 10% solvent B at 150 μL/min; 17-17.5 min, CH:FLOW_GRADIENT 90% solvent B at 150 μL/min; 17.5-18 min, 90% solvent B at 150 μL/min; 18- CH:FLOW_GRADIENT 18.5 min, ramped to 90% solvent B at 250 μL/min; 18.5-19 min, held at 90% CH:FLOW_GRADIENT solvent B at 250 μL/min; 19-19.5 min, 90% solvent B at 400 μL/min; 19.5-23.5 CH:FLOW_GRADIENT min, held at 90% solvent B at 400 μL/min; 23.5-24 min, 90% solvent B at 250 CH:FLOW_GRADIENT μL/min; 24-25 min, held at 90% solvent B at 250 μL/min. CH:FLOW_RATE 0-14 min, 250 μL/min; 14-18 min, 150 μL/min; 18-19 min, 250 μL/min; 19-23.5 CH:FLOW_RATE min, 400 μL/min; 23.5-25 min, 250 μL/min. CH:COLUMN_TEMPERATURE 40 #ANALYSIS AN:ANALYSIS_TYPE MS #MS MS:INSTRUMENT_NAME Thermo Q Exactive Plus Orbitrap MS:INSTRUMENT_TYPE Orbitrap MS:MS_TYPE ESI MS:ION_MODE POSITIVE MS:MS_COMMENTS MS was acquired in full-scan mode from 65-950 m/z using the following source MS:MS_COMMENTS settings: spray voltage, +3 kV; sheath gas flow rate, 50; auxiliary gas flow MS:MS_COMMENTS rate, 10; sweep gas flow rate, 1; S-lens RF level, 30%; capillary temperature, MS:MS_COMMENTS 300 °C; and auxiliary gas heater temperature, 350 °C. Skyline software was MS:MS_COMMENTS used for data processing. #MS_METABOLITE_DATA MS_METABOLITE_DATA:UNITS Peak Areas MS_METABOLITE_DATA_START Samples Pos_Anti_1_Brain Pos_Anti_2_Brain Pos_Anti_3_Brain Pos_Anti_4_Brain Pos_Anti_5_Brain Pos_Anti_6_Brain Pos_Anti_7_Brain Pos_Anti_8_Brain Pos_Anti_9_Brain Pos_Anti_10_Brain Pos_Ctrl_11_Brain Pos_Ctrl_13_Brain Pos_Ctrl_14_Brain Pos_Ctrl_15_Brain Pos_Ctrl_16_Brain Pos_Ctrl_17_Brain Pos_Ctrl_18_Brain Pos_Ctrl_19_Brain Pos_Anti_1_Eye Pos_Anti_2_Eye Pos_Anti_3_Eye Pos_Anti_4_Eye Pos_Anti_5_Eye Pos_Anti_6_Eye Pos_Anti_7_Eye Pos_Anti_8_Eye Pos_Anti_9_Eye Pos_Anti_10_Eye Pos_Ctrl_11_Eye Pos_Ctrl_12_Eye Pos_Ctrl_13_Eye Pos_Ctrl_14_Eye Pos_Ctrl_15_Eye Pos_Ctrl_16_Eye Pos_Ctrl_17_Eye Pos_Ctrl_18_Eye Pos_Anti_1_Fin Pos_Anti_2_Fin Pos_Anti_3_Fin Pos_Anti_4_Fin Pos_Anti_5_Fin Pos_Anti_6_Fin Pos_Anti_7_Fin Pos_Anti_8_Fin Pos_Anti_9_Fin Pos_Anti_10_Fin Pos_Ctrl_11_Fin Pos_Ctrl_12_Fin Pos_Ctrl_13_Fin Pos_Ctrl_14_Fin Pos_Ctrl_15_Fin Pos_Ctrl_16_Fin Pos_Ctrl_17_Fin Pos_Ctrl_18_Fin Pos_Ctrl_19_Fin Pos_Anti_1_Heart Pos_Anti_2_Heart Pos_Anti_3_Heart Pos_Anti_4_Heart Pos_Anti_5_Heart Pos_Anti_6_Heart Pos_Anti_7_Heart Pos_Anti_8_Heart Pos_Anti_9_Heart Pos_Anti_10_Heart Pos_Ctrl_11_Heart Pos_Ctrl_12_Heart Pos_Ctrl_13_Heart Pos_Ctrl_14_Heart Pos_Ctrl_15_Heart Pos_Ctrl_16_Heart Pos_Ctrl_19_Heart Pos_Anti_1_Intestine Pos_Anti_2_Intestine Pos_Anti_3_Intestine Pos_Anti_4_Intestine Pos_Anti_5_Intestine Pos_Anti_6_Intestine Pos_Anti_7_Intestine Pos_Anti_8_Intestine Pos_Anti_9_Intestine Pos_Anti_10_Intestine Pos_Ctrl_11_Intestine Pos_Ctrl_12_Intestine Pos_Ctrl_13_Intestine Pos_Ctrl_14_Intestine Pos_Ctrl_15_Intestine Pos_Ctrl_16_Intestine Pos_Ctrl_17_Intestine Pos_Ctrl_19_Intestine Pos_Anti_1_Liver Pos_Anti_2_Liver Pos_Anti_3_Liver Pos_Anti_4_Liver Pos_Anti_5_Liver Pos_Anti_6_Liver Pos_Anti_7_Liver Pos_Anti_8_Liver Pos_Anti_9_Liver Pos_Anti_10_Liver Pos_Ctrl_11_Liver Pos_Ctrl_12_Liver Pos_Ctrl_13_Liver Pos_Ctrl_14_Liver Pos_Ctrl_15_Liver Pos_Ctrl_17_Liver Pos_Ctrl_18_Liver Pos_Ctrl_19_Liver Pos_Anti_1_Muscle Pos_Anti_2_Muscle Pos_Anti_3_Muscle Pos_Anti_4_Muscle Pos_Anti_5_Muscle Pos_Anti_6_Muscle Pos_Anti_7_Muscle Pos_Anti_8_Muscle Pos_Anti_9_Muscle Pos_Anti_10_Muscle Pos_Ctrl_11_Muscle Pos_Ctrl_12_Muscle Pos_Ctrl_13_Muscle Pos_Ctrl_14_Muscle Pos_Ctrl_15_Muscle Pos_Ctrl_16_Muscle Pos_Ctrl_17_Muscle Pos_Ctrl_18_Muscle Pos_Ctrl_19_Muscle Pos_Anti_1_Serum Pos_Anti_2_Serum Pos_Anti_4_Serum Pos_Anti_5_Serum Pos_Anti_6_Serum Pos_Anti_7_Serum Pos_Anti_8_Serum Pos_Anti_9_Serum Pos_Anti_10_Serum Pos_Ctrl_11_Serum Pos_Ctrl_12_Serum Pos_Ctrl_13_Serum Pos_Ctrl_15_Serum Pos_Ctrl_16_Serum Pos_Ctrl_18_Serum Pos_Ctrl_19_Serum Factors Treatment:Antimicrobials | Sample source:Brain Treatment:Antimicrobials | Sample source:Brain Treatment:Antimicrobials | Sample source:Brain Treatment:Antimicrobials | Sample source:Brain Treatment:Antimicrobials | Sample source:Brain Treatment:Antimicrobials | Sample source:Brain Treatment:Antimicrobials | Sample source:Brain Treatment:Antimicrobials | Sample source:Brain Treatment:Antimicrobials | Sample source:Brain Treatment:Antimicrobials | Sample source:Brain Treatment:Control | Sample source:Brain Treatment:Control | Sample source:Brain Treatment:Control | Sample source:Brain Treatment:Control | Sample source:Brain Treatment:Control | Sample source:Brain Treatment:Control | Sample source:Brain Treatment:Control | Sample source:Brain Treatment:Control | Sample source:Brain Treatment:Antimicrobials | Sample source:Eye Treatment:Antimicrobials | Sample source:Eye Treatment:Antimicrobials | Sample source:Eye Treatment:Antimicrobials | Sample source:Eye Treatment:Antimicrobials | Sample source:Eye Treatment:Antimicrobials | Sample source:Eye Treatment:Antimicrobials | Sample source:Eye Treatment:Antimicrobials | Sample source:Eye Treatment:Antimicrobials | Sample source:Eye Treatment:Antimicrobials | Sample source:Eye Treatment:Control | Sample source:Eye Treatment:Control | Sample source:Eye Treatment:Control | Sample source:Eye Treatment:Control | Sample source:Eye Treatment:Control | Sample source:Eye Treatment:Control | Sample source:Eye Treatment:Control | Sample source:Eye Treatment:Control | Sample source:Eye Treatment:Antimicrobials | Sample source:Fin Treatment:Antimicrobials | Sample source:Fin Treatment:Antimicrobials | Sample source:Fin Treatment:Antimicrobials | Sample source:Fin Treatment:Antimicrobials | Sample source:Fin Treatment:Antimicrobials | Sample source:Fin Treatment:Antimicrobials | Sample source:Fin Treatment:Antimicrobials | Sample source:Fin Treatment:Antimicrobials | Sample source:Fin Treatment:Antimicrobials | Sample source:Fin Treatment:Control | Sample source:Fin Treatment:Control | Sample source:Fin Treatment:Control | Sample source:Fin Treatment:Control | Sample source:Fin Treatment:Control | Sample source:Fin Treatment:Control | Sample source:Fin Treatment:Control | Sample source:Fin Treatment:Control | Sample source:Fin Treatment:Control | Sample source:Fin Treatment:Antimicrobials | Sample source:Heart Treatment:Antimicrobials | Sample source:Heart Treatment:Antimicrobials | Sample source:Heart Treatment:Antimicrobials | Sample source:Heart Treatment:Antimicrobials | Sample source:Heart Treatment:Antimicrobials | Sample source:Heart Treatment:Antimicrobials | Sample source:Heart Treatment:Antimicrobials | Sample source:Heart Treatment:Antimicrobials | Sample source:Heart Treatment:Antimicrobials | Sample source:Heart Treatment:Control | Sample source:Heart Treatment:Control | Sample source:Heart Treatment:Control | Sample source:Heart Treatment:Control | Sample source:Heart Treatment:Control | Sample source:Heart Treatment:Control | Sample source:Heart Treatment:Control | Sample source:Heart Treatment:Antimicrobials | Sample source:Intestine Treatment:Antimicrobials | Sample source:Intestine Treatment:Antimicrobials | Sample source:Intestine Treatment:Antimicrobials | Sample source:Intestine Treatment:Antimicrobials | Sample source:Intestine Treatment:Antimicrobials | Sample source:Intestine Treatment:Antimicrobials | Sample source:Intestine Treatment:Antimicrobials | Sample source:Intestine Treatment:Antimicrobials | Sample source:Intestine Treatment:Antimicrobials | Sample source:Intestine Treatment:Control | Sample source:Intestine Treatment:Control | Sample source:Intestine Treatment:Control | Sample source:Intestine Treatment:Control | Sample source:Intestine Treatment:Control | Sample source:Intestine Treatment:Control | Sample source:Intestine Treatment:Control | Sample source:Intestine Treatment:Control | Sample source:Intestine Treatment:Antimicrobials | Sample source:Liver Treatment:Antimicrobials | Sample source:Liver Treatment:Antimicrobials | Sample source:Liver Treatment:Antimicrobials | Sample source:Liver Treatment:Antimicrobials | Sample source:Liver Treatment:Antimicrobials | Sample source:Liver Treatment:Antimicrobials | Sample source:Liver Treatment:Antimicrobials | Sample source:Liver Treatment:Antimicrobials | Sample source:Liver Treatment:Antimicrobials | Sample source:Liver Treatment:Control | Sample source:Liver Treatment:Control | Sample source:Liver Treatment:Control | Sample source:Liver Treatment:Control | Sample source:Liver Treatment:Control | Sample source:Liver Treatment:Control | Sample source:Liver Treatment:Control | Sample source:Liver Treatment:Control | Sample source:Liver Treatment:Antimicrobials | Sample source:Muscle Treatment:Antimicrobials | Sample source:Muscle Treatment:Antimicrobials | Sample source:Muscle Treatment:Antimicrobials | Sample source:Muscle Treatment:Antimicrobials | Sample source:Muscle Treatment:Antimicrobials | Sample source:Muscle Treatment:Antimicrobials | Sample source:Muscle Treatment:Antimicrobials | Sample source:Muscle Treatment:Antimicrobials | Sample source:Muscle Treatment:Antimicrobials | Sample source:Muscle Treatment:Control | Sample source:Muscle Treatment:Control | Sample source:Muscle Treatment:Control | Sample source:Muscle Treatment:Control | Sample source:Muscle Treatment:Control | Sample source:Muscle Treatment:Control | Sample source:Muscle Treatment:Control | Sample source:Muscle Treatment:Control | Sample source:Muscle Treatment:Control | Sample source:Muscle Treatment:Antimicrobials | Sample source:Serum Treatment:Antimicrobials | Sample source:Serum Treatment:Antimicrobials | Sample source:Serum Treatment:Antimicrobials | Sample source:Serum Treatment:Antimicrobials | Sample source:Serum Treatment:Antimicrobials | Sample source:Serum Treatment:Antimicrobials | Sample source:Serum Treatment:Antimicrobials | Sample source:Serum Treatment:Antimicrobials | Sample source:Serum Treatment:Control | Sample source:Serum Treatment:Control | Sample source:Serum Treatment:Control | Sample source:Serum Treatment:Control | Sample source:Serum Treatment:Control | Sample source:Serum Treatment:Control | Sample source:Serum Treatment:Control | Sample source:Serum BETA-NICOTINAMIDE ADENINE DINUCLEOTIDE 38958536 24753206 58747088 55291880 29664902 56248764 96060256 40628564 48317252 37384020 54324124 50650156 32125500 53292404 71258008 57661956 48759284 82464480 40515992 32055896 29152894 21918378 26419302 19451032 30645238 43079896 21269678 51467228 38352496 38136448 39556596 48801812 37463044 44767176 35453472 13548519 76911928 33464176 82929408 49596468 40165220 41683288 42838280 40918596 69588712 54376088 79925040 36973840 36298520 42022184 81110112 58989848 61002796 60797060 78935568 59484156 6826954 77487232 56054144 94139984 92214312 87381776 66895984 64135952 78250928 81939192 96718704 85298008 30210584 74843608 78750232 135172880 56689124 60613116 49141524 32475366 40058316 55235608 60150200 42167244 48951912 46042872 51174756 34658552 22540370 53745644 43318836 39785416 65308200 93481040 94921432 53150420 125719216 113390480 103845192 112309400 99824016 79324568 75031528 62718756 77769472 115321904 20972318 98305976 53892816 40401580 55809688 279070656 52878164 45643724 53222536 54718592 46582844 42061660 57658000 76045976 67245536 32842260 44258284 51181564 73254768 58640268 78027456 46021608 53444652 60194120 66890836 CYTIDINE 56874264 13913792 49891620 42528820 69157752 117526048 245864656 124697792 60110204 57793552 64975448 22470954 36362792 66725516 145265088 95398328 104137368 88767920 54006124 45771248 36983248 37323564 32431596 48771356 54067104 75530760 19416580 85218792 43022300 95252736 43569324 60687908 53347296 92009016 62056128 18727800 282697504 157476992 305507424 297537536 346506624 197699712 158065808 327159488 335129664 279704192 552074432 162982912 176489408 226217968 360778176 302153472 588457664 728782080 302563616 41887228 67298872 14801804 24439360 63439152 229128112 39006296 45328656 30214894 55598680 75764544 84244064 18003108 14083275 45780216 35846352 72071080 184393744 187797200 222843600 193639712 372116800 428036064 276106240 275143488 348370432 362967296 444937376 180705712 197715520 143688320 289488736 362089216 427244672 236186464 38831600 51266500 30676910 32726956 67360120 30197180 27340772 34873056 53318772 18021882 49661408 22159862 86064744 31111290 13683159 164120560 88806968 86284976 70892584 75747192 115076200 89084944 33773336 39863696 47158052 162688288 105182472 22625986 63319724 44743900 64162704 52262008 61789152 41391020 73208456 65755884 58052360 134739680 118728488 73716896 62984904 52804240 81836016 109570128 62319988 137463952 66666104 59315040 49824860 69208904 115926728 77568200 764874 CITRULLINE 302726816 254196752 195144752 205496176 115391360 221582192 258507024 302731776 321359168 135724144 591067968 356794368 339602400 321517632 608783680 616796416 229439760 939152832 518040384 634274176 239884112 265998288 192876320 228235072 323202816 357961696 342654144 492661344 909378304 582782912 922588288 860644288 633632640 1163188096 930934592 201003344 772435264 411107392 554307136 620762112 386356736 545836928 697969920 638430592 658904704 733745600 1752375808 538491456 1123425664 1161365760 1018626304 2523127808 1265286016 740209792 2234286336 386255872 625552064 180060560 229018816 333554528 542497088 204873072 227406320 192457536 438103904 1247584896 544716352 444769760 373815136 429970656 488014880 1281098624 1483970048 2784700672 997676544 1083819392 1261887616 1007610624 1084403840 983797696 1319763584 1420096256 2950522368 1337981952 1431965056 1572578944 2129318400 2053295744 2449909504 3227217408 2350680064 1514878848 1654836736 1635301376 1417982080 1336587648 1048895488 1024084224 2003971712 1231272448 4163161600 1621229440 744135808 2141829376 2074217216 1595151744 1122281344 4824973312 381165696 569790400 319023840 350597120 166842992 171268176 161017152 319598400 322527840 156191888 719511680 338417376 478795008 498814528 445056800 521908832 593255936 396519776 695090816 1650850304 2412709376 767041088 647070528 537561472 807085952 1108968960 1087724544 1015526976 4527661568 1282404480 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367085216 504081664 633590080 1112044032 462684672 633184448 413630656 482097600 341278176 350218688 347419232 810480640 386921248 138938816 998424832 651717824 797435840 1111570560 1403189760 1722998656 2635438848 909889728 1818156032 1780176000 5068042240 2679958784 706494016 934301632 779455488 1435745536 1211937792 742345792 945864640 1783288192 1109189376 1141016320 2174043136 3610945024 2190824192 1948511616 1033822208 3831963136 4409314304 1009435264 7200497664 717095680 875632896 724628608 671117696 3254628608 1542141824 59869 N-ACETYLGLUCOSAMINE 17411344 19561140 3565136 29428746 2276178 3839477 5138896 5623780 677930 2774197 6285051 3741787 2548463 4406100 5066812 7579358 6304596 8930522 86438336 66423300 9062722 44836420 9479392 4821810 14783140 19174716 8268675 23846036 20737038 142255152 23865442 16381042 16267736 20525110 19307984 5783934 38176984 19866704 10427676 33551112 12494458 12121753 10629279 13223675 18029928 19486158 22773390 33834640 11101683 19031486 23774436 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1765406 1302543 2113580 421468 246847 102133 578065 219658 477890 928320 1422483 738012 1048569 431041 312674 492079 1318548 879562 1176549 1503081 348423 3338861 1174222 1935796 1026583 1868125 395548 391025 552017 1731889 1708431 1318043 352581 329140 1552977 2900311 415282 1006398 1276733 1233792 1525910 348030 3854726 2522484 3840225 3831251 6109155 4062125 2599904 2186145 3743211 2355753 3263187 1937509 1206525 4486904 5191959 6616196 7515661 5556874 15163064 4300480 5543823 3899287 3889242 2880324 5641491 3232773 4419812 1770345 2500094 1611108 3724814 3972662 2327429 1948774 1784400 1384280 775039 1669057 1155697 1554748 835444 450291 1129201 1314499 1198463 1470114 1834153 1538517 1153118 1274629 3370743 2975883 1658433 2065321 4892791 4819717 3185673 5220103 4893121 3443047 3061294 1644324 2576076 10738615 5359655 6558229 7420035 3920423 2665400 6325815 1780452 723734 596795 1276430 1022111 1015419 733814 1866264 133949 1581846 78248 97842 163845 748786 2271098 380234 ADENOSINE 119587600 24240434 111517376 99757592 250530928 281475872 460689024 184965456 86375864 155512832 168706304 55167844 86982584 167248848 419659232 211333840 227044448 412150944 319624992 288339328 292454368 287726944 270295200 491274272 272711648 448252352 93970528 448693376 356014688 178141744 461031616 379083104 690656320 662103040 210901616 381848768 2903889920 1445113856 2962940672 1510795776 3760785152 3605395456 3268721664 3150079232 1583644800 3587254784 3301137408 1586370944 3389495040 3273448192 2570695936 3141350912 3783314944 4524923904 2985874944 1184789760 546076352 360448512 626804800 2558985216 744444864 1059284992 856832640 1576212224 1434497664 1088510976 1615766272 700163648 855801664 1209691648 870325504 722192320 1754450304 3144482304 1673976832 1947215488 1867776000 3297436928 2472475904 2689025536 2413052928 4251636480 4825878528 2948055296 5418744320 2525877248 4578112512 5827142144 2823544320 2327368192 1241208704 648713408 1446887808 997839360 703333248 1319985024 947272448 393243616 1855406464 892050304 1232692352 798034624 1777629824 1557795456 568435072 1435931776 1732149888 851950080 4275771392 3738559232 8165199360 7544239616 4239907328 7532450304 7006501376 9295973376 7285824512 3663644416 4834240512 4675623936 6991672832 5534598656 6185267200 4538328576 5309883904 6076582912 5440327168 283153888 677353024 27430046 687237824 69493712 1021256576 338934624 223655632 439570976 61113144 27107870 43694212 44816368 458582944 32429468 516304 PHOSPHOCREATINE 239596720 877049728 813953984 795143872 267728880 503111616 126487760 76861824 258212704 293316032 703777920 664658368 169236880 802722816 579012992 551297472 448883680 770235008 392954848 371602304 215157248 211921632 254664176 60891064 373272928 272233408 237619536 309745952 422184192 328272256 509725824 510042752 482217120 508058080 437064576 109100192 485516192 186306944 986913600 443636992 372780256 334517664 791674624 496911168 871443776 473516352 576041024 405129888 650722304 975659712 1007665856 1028181312 602040768 535958400 1874721024 375725312 30538440 900193728 1164070784 780052416 1315537408 1891105280 1255110784 456919008 751160000 1807987072 2039034368 2244909312 225687472 1624944256 2098501504 1058470208 1307199360 426020512 307310272 559961920 940015040 979154432 830884096 695328960 1447281024 1083902080 1789018752 885435904 458323488 1256097920 567494848 550778816 1192818688 1048579840 305568864 80061848 142345296 220793616 123778808 316780928 368079136 385577216 88444608 181238848 417092064 183139824 414132160 196984896 364382080 849373248 118357920 748565440 1877816576 3095187712 3272385536 2689835520 3025116928 1702628736 3612724992 3034230272 7435781632 2359378432 4303770624 4362677760 5978572800 6809686016 5111695360 4453328384 5202075136 5696519680 8168672256 114683432 51959492 257665072 147911632 56492608 372747616 781302656 75103864 461873760 195528448 95973312 95754424 126402280 362415104 288449440 35265 OPHTHALMATE 27917628 15779034 34682032 58988296 57029976 46910340 113208704 37184744 39258672 45770852 124002264 46960692 68921664 135608128 74914688 104501784 31956084 157606800 324510272 389999072 196846464 670891264 462107040 55080932 552776448 513961696 296508320 928138688 705743808 791133760 901890304 558195520 791814016 625065408 900131456 1346748416 20816664 3840401 17078816 40158348 26190224 10495847 10272323 15989518 15032045 14767292 56591728 12426904 12576061 17548116 24794046 8610393 44172616 24667598 23329692 32557670 14997496 28125580 58531116 49158412 43069952 27224280 33248108 16645863 83319632 85518136 56036180 40640720 35252192 59583076 24869742 115827480 233292160 137024960 232139200 372811456 177952992 314643904 274897408 294922912 252358336 480779040 263599328 45897648 27326918 128318424 65576164 66884720 155233072 57609664 30157350 16595756 36886576 51340780 43977136 39024952 32587134 25015164 26149920 34684000 125516064 21977514 26721730 28950180 21059226 120158624 24537168 54640268 24011444 25565950 18915306 47025620 26183950 18756466 20007964 26240202 26079418 23006260 63967184 22515118 32122162 36230240 59132392 8618022 29663870 21930164 37102456 TRIGONELLINE 6829334 2807342 27253052 43817916 11504521 6767418 29338698 24567076 8840998 7069846 4276505 14919295 7613592 15301105 39822092 13507635 14298160 72881672 12933354 7163622 28432642 35755496 17503844 4803722 21007830 27226502 6824400 28229224 8826599 45132940 24524608 21183664 23890024 51513524 19009116 7582899 19263864 3668512 87195144 89339936 82850848 9241621 28030202 26508262 23915614 26951890 12842499 55500752 22772538 32268032 52612852 53162236 54402500 34186224 125734336 13865409 4179455 26689870 33146060 36223304 15299818 20899664 16298238 9351575 22924676 15366550 54283496 10098842 9091756 21984222 29095318 95206536 35554864 27638688 102564016 71589176 105615504 16275406 71970016 25073400 24674120 27791832 57491008 66431532 24909000 47400816 54349872 124065608 70372744 169375072 88492208 20455016 327319840 247145424 321785632 75472392 208123392 114736208 86069832 109107696 13093391 254703232 22575448 78738248 79160248 26810892 10767032 448226336 47213284 18216598 146693424 133202704 63974516 20110264 111302640 133698320 74060048 26410038 21287254 77969400 61900596 53534256 54629944 61524140 44721300 60248588 134837376 32052200 19075516 184200560 77692464 13336851 80243424 121094440 13891239 93556288 36374752 90714832 51003708 126151592 136125696 145691744 121907 4-AMINOBENZOATE 12271198 11088523 12684889 1182109 614927 10165326 7229173 22254012 28204298 8559284 8477808 7119949 2679098 42169012 33804552 13618628 15738011 60776592 12019135 15596419 5927108 1509322 1519486 5449025 5806103 15513495 9518437 17991258 7127119 29929424 10574460 4521946 42651288 33976388 8964425 12254191 14980618 7329592 14145183 3055964 1326128 6523140 4793634 11312454 18838456 14306059 11172822 18572952 8500276 6114349 55253460 36260152 13027754 25881274 64043252 13479371 17994988 5392577 1933218 2974468 11893317 6003640 11078145 13421577 18513660 13812707 50364012 8314754 3689218 91360216 23792986 62849552 13006511 22080252 10945825 4095926 3671437 14311643 6278933 10838990 29153958 15243712 19375710 27335398 12406370 5557876 54303884 45816656 16755117 69236680 9554704 10198492 11434105 760045 799483 6994835 5158731 4804658 10141755 5030010 7163109 17726644 4540988 2295768 23218894 5073303 10317546 52795332 75587992 102975992 70814176 8499387 11365964 57379200 80824720 197405936 289218816 62479028 30972688 126708120 139371216 26189510 276145984 98561296 23197062 136335648 369300896 52914300 155539104 5106083 7515218 32420886 60265596 145357936 59871956 155265648 47581044 116426360 36854228 322782720 157580672 185532064 329806 HEXANOATE 100080368 130990488 73011168 42574028 76626240 5939580 144790016 275011520 138069632 169600832 129973416 56505712 57549252 45944240 27166100 27324034 45798092 71030904 73807240 117636744 23117694 108997792 59773988 57823848 127143224 58540780 85659088 79015336 176329280 145108736 131219272 141519536 131154848 106244200 114738952 106945176 402564128 518387456 400426496 401612704 216674176 312856672 170503648 175004032 334566368 334564736 491640992 182275632 242019408 298275776 421960192 358790656 378941344 414227776 440904192 61218548 98436784 65842116 157325248 131475296 67720560 78328520 33713840 176966448 42717988 74127624 72698632 146881776 65936008 76170784 46341820 94904336 42295816 57128060 26745202 79084992 160175952 15360296 96434736 141778144 41881188 81452976 26231410 34381364 58258660 50748696 52610988 41661308 34667424 44798104 278388864 294683200 234460912 344266592 293901440 234811280 471402560 223850176 192776480 363977312 214725008 267223360 376471808 293447072 246729056 344060128 287872576 431195296 311432128 304869760 320079392 412824768 234060624 401798752 322919328 376325856 276340352 255762096 207635552 357457568 377199584 465010240 290851456 191316368 340476160 470395872 274320224 138659936 176268064 390176064 50075176 162984208 319168352 326379872 41228528 407811648 59138072 87374608 81358776 313483584 452375776 385355104 251698 PTERIN 15054364 6687700 2747655 3066554 3014349 3101453 8024003 5087173 10185806 3125500 13169528 5569633 5663694 4011555 8350994 5916001 19428692 1601053 14899695 4846605 5251294 4260506 5533060 5126533 7773253 2204806 14655675 4438383 14860353 2419913 2849942 4243021 8936439 7325608 12688297 6339730 6575069 149591 438175 68269 181060 33898 726907 49695 96669 103731 237452 343168 87001 91890 163019 160956 173030 52915 1205670 1630535 324763 599659 670394 575041 578574 192478 1068690 362691 1026980 1093534 565950 355174 478261 1455643 1055761 829024 2667173 1559386 2277876 2191931 896114 2754725 2568195 1768560 2483480 3674021 1299090 3322083 623135 4612750 2262709 2286176 1527504 3415341 2207980 1266015 1818525 548543 204194 580306 381531 472471 989187 213714 828514 506826 307724 317315 858049 612573 898261 3106408 429374 349503 387981 919670 435418 333456 171769 272967 540990 455774 346505 88302 288148 558184 307275 327003 89405 DIHYDROBIOPTERIN 1178659 1040125 2073725 2237812 1025186 2604230 3398915 4109081 2264395 1879472 2537438 1402129 837030 2600869 3661206 3417594 3587290 11013233 2955399 1584761 2475202 2580239 2810647 1923261 6281992 10708538 1993631 17165948 3193912 29652782 12970702 7038281 3630980 4176803 3872923 3531497 15597500 5574602 191351312 29337020 48768540 107580184 87043160 136182592 17120000 178338240 7879406 85288696 122028216 165365728 9522303 23367564 9449950 143053456 186968592 543052 944286 94625 264341 322485 3342043 62634 638641 66239 3185546 114150 567856 134529 20487 366805 237195 202543 3449798 4724219 2418482 4590695 4068530 3286881 3601991 2704156 2150735 2807039 4690269 2238533 3284034 4497463 7384081 4476755 3860452 11956387 7522582 1664846 6765731 4589752 5305920 6948517 2698914 3518832 12770230 5117955 8569178 7322172 1116020 6856110 7001623 2810158 10128016 24484864 5139716 1974479 63408740 2869008 3425462 7850309 5020655 44097764 709491 23696204 523821 19842870 14943448 12948180 2139883 1545537 1855842 32766036 11226038 PYRIDOXAL 25967840 11395054 31551860 32267438 16089301 23754642 28299094 18142066 32339684 27685926 18010846 6580688 12602353 16718286 18892524 13873428 19946296 17192700 7961267 8850978 8300771 12258275 9995943 10194709 6965564 11517220 5189542 10708546 6488128 10742500 9042029 18601174 13399275 17060916 6111882 7130464 1725871 1635937 2697743 3411208 4035713 2824174 3100162 2430109 1955271 3237149 1557771 4058383 4607668 3801471 4144173 6970748 2529815 4059215 4882683 2214860 4776724 1166916 2413237 2678061 4030872 2747946 1473599 1837593 4708207 7362033 4767224 4026567 2957523 4272772 3268094 4130374 3086422 2741319 3184898 3790263 4804726 4693799 3940792 3722559 542662 2493687 1309130 2558731 5238741 4402579 3607883 3450439 3543596 1590147 4182592 19139696 4203638 3519622 4011847 4833121 3727069 2567915 2477256 3034479 1096228 7418308 3303563 4892948 5225536 3164300 5870989 3254513 1753626 3788168 4349659 3678885 1250138 3032139 2221631 2129016 2232496 1340984 599599 6770896 3726379 2319634 5136154 3715023 2002898 5448149 4087326 20351664 31306050 52414084 23470194 16765533 29647526 24294600 17167984 20296242 11045382 50349928 33458526 60527648 66899184 54124536 88350 MS_METABOLITE_DATA_END #METABOLITES METABOLITES_START metabolite_name BETA-NICOTINAMIDE ADENINE DINUCLEOTIDE CYTIDINE CITRULLINE INOSINE N-ACETYLGLUCOSAMINE CREATININE GUANIDINOACETATE DIETHANOLAMINE HYPOXANTHINE CREATINE GUANOSINE GUANINE HOMOSERINE NICOTINAMIDE MONONUCLEOTIDE 3-METHYL-L-HISTIDINE AMINOADIPATE BETAINE 1-METHYL-L-HISTIDINE UROCANATE CITICOLINE CYSTATHIONINE NICOTINAMIDE HYPOXANTHINE DINUCLEOTIDE S-ADENOSYLMETHIONINE DEOXYCARNITINE PHOSPHORYLCHOLINE O-ACETYLCARNITINE N_N_N-TRIMETHYLLYSINE L-CARNITINE FAD ADENINE N_N-DIMETHYLARGININE 4-GUANIDINOBUTANOATE UREIDOPROPIONATE ADENOSINE PHOSPHOCREATINE OPHTHALMATE TRIGONELLINE 4-AMINOBENZOATE HEXANOATE PTERIN DIHYDROBIOPTERIN PYRIDOXAL METABOLITES_END #END