#METABOLOMICS WORKBENCH xudanyan_20250717_054335 DATATRACK_ID:6184 STUDY_ID:ST004086 ANALYSIS_ID:AN006773 PROJECT_ID:PR002565
VERSION             	1
CREATED_ON             	July 30, 2025, 10:07 pm
#PROJECT
PR:PROJECT_TITLE                 	Levels of EETs and DHETs in murine plasma were quantified using liquid
PR:PROJECT_TITLE                 	chromatography-mass spectrometry (LC-MS)
PR:PROJECT_SUMMARY               	Fresh plasma samples were collected from the following experimental mouse
PR:PROJECT_SUMMARY               	groups:(1) Sham-operated controls,(2) Abdominal aortic constriction
PR:PROJECT_SUMMARY               	(AAC)-induced cardiac hypertrophy model,(3) AAC + aerobic exercise training,(4)
PR:PROJECT_SUMMARY               	AAC + TPPU (sEH inhibitor) treatment, and (5) AAC + aerobic exercise training +
PR:PROJECT_SUMMARY               	AAV-mediated soluble epoxide hydrolase (sEH) overexpression. The impact of these
PR:PROJECT_SUMMARY               	interventions on circulating levels of epoxyeicosatrienoic acids (EETs) and
PR:PROJECT_SUMMARY               	their metabolites dihydroxyeicosatrienoic acids (DHETs) was quantitatively
PR:PROJECT_SUMMARY               	analyzed using liquid chromatography-mass spectrometry (LC-MS).
PR:INSTITUTE                     	Second xiangya hospital of central south university
PR:LAST_NAME                     	xu
PR:FIRST_NAME                    	danyan
PR:ADDRESS                       	NO.139 in renmin middle road, Changsha, Hunan province, 410011, China
PR:EMAIL                         	xudanyan02@csu.edu.cn
PR:PHONE                         	+86 13974874636
#STUDY
ST:STUDY_TITLE                   	Quantification of Levels of EETs and DHETs in murine plasma in Abdominal aortic
ST:STUDY_TITLE                   	constriction (AAC)-induced cardiac hypertrophy model using LC-MS
ST:STUDY_SUMMARY                 	Fresh plasma samples were collected from the following experimental mouse
ST:STUDY_SUMMARY                 	groups:(1) Sham-operated controls,(2) Abdominal aortic constriction
ST:STUDY_SUMMARY                 	(AAC)-induced cardiac hypertrophy model,(3) AAC + aerobic exercise training,(4)
ST:STUDY_SUMMARY                 	AAC + TPPU (sEH inhibitor) treatment, and (5) AAC + aerobic exercise training +
ST:STUDY_SUMMARY                 	AAV-mediated soluble epoxide hydrolase (sEH) overexpression. The impact of these
ST:STUDY_SUMMARY                 	interventions on circulating levels of epoxyeicosatrienoic acids (EETs) and
ST:STUDY_SUMMARY                 	their metabolites dihydroxyeicosatrienoic acids (DHETs) was quantitatively
ST:STUDY_SUMMARY                 	analyzed using liquid chromatography-mass spectrometry (LC-MS).
ST:INSTITUTE                     	Second xiangya hospital of central south university
ST:LAST_NAME                     	xu
ST:FIRST_NAME                    	danyan
ST:ADDRESS                       	NO.139 in renmin middle road, Changsha, Hunan province, 410011, China
ST:EMAIL                         	xudanyan02@csu.edu.cn
ST:PHONE                         	+86 13974874636
#SUBJECT
SU:SUBJECT_TYPE                  	Mammal
SU:SUBJECT_SPECIES               	Mus musculus
SU:TAXONOMY_ID                   	10090
#SUBJECT_SAMPLE_FACTORS:         	SUBJECT(optional)[tab]SAMPLE[tab]FACTORS(NAME:VALUE pairs separated by |)[tab]Raw file names and additional sample data
SUBJECT_SAMPLE_FACTORS           	A1	Sample001	Sample source:blood | Treatment:AAC+Ex+AAV-sEH	RAW_FILE_NAME(Raw file name)=Danyan Xu-Sample001.mzML
SUBJECT_SAMPLE_FACTORS           	A2	Sample002	Sample source:blood | Treatment:SHAM	RAW_FILE_NAME(Raw file name)=Danyan Xu-Sample002.mzML
SUBJECT_SAMPLE_FACTORS           	A75	Sample003	Sample source:blood | Treatment:AAC+Ex	RAW_FILE_NAME(Raw file name)=Danyan Xu-Sample003.mzML
SUBJECT_SAMPLE_FACTORS           	A77	Sample004	Sample source:blood | Treatment:AAC+TPPU	RAW_FILE_NAME(Raw file name)=Danyan Xu-Sample004.mzML
SUBJECT_SAMPLE_FACTORS           	A79	Sample005	Sample source:blood | Treatment:AAC+Ex+AAV-sEH	RAW_FILE_NAME(Raw file name)=Danyan Xu-Sample005.mzML
SUBJECT_SAMPLE_FACTORS           	A80	Sample006	Sample source:blood | Treatment:AAC+Ex	RAW_FILE_NAME(Raw file name)=Danyan Xu-Sample006.mzML
SUBJECT_SAMPLE_FACTORS           	A83	Sample007	Sample source:blood | Treatment:SHAM	RAW_FILE_NAME(Raw file name)=Danyan Xu-Sample007.mzML
SUBJECT_SAMPLE_FACTORS           	A84	Sample008	Sample source:blood | Treatment:AAC	RAW_FILE_NAME(Raw file name)=Danyan Xu-Sample008.mzML
SUBJECT_SAMPLE_FACTORS           	A87	Sample009	Sample source:blood | Treatment:AAC+TPPU	RAW_FILE_NAME(Raw file name)=Danyan Xu-Sample009.mzML
SUBJECT_SAMPLE_FACTORS           	A88	Sample010	Sample source:blood | Treatment:SHAM	RAW_FILE_NAME(Raw file name)=Danyan Xu-Sample010.mzML
SUBJECT_SAMPLE_FACTORS           	A89	Sample011	Sample source:blood | Treatment:AAC+TPPU	RAW_FILE_NAME(Raw file name)=Danyan Xu-Sample011.mzML
SUBJECT_SAMPLE_FACTORS           	A90	Sample012	Sample source:blood | Treatment:AAC+TPPU	RAW_FILE_NAME(Raw file name)=Danyan Xu-Sample012.mzML
SUBJECT_SAMPLE_FACTORS           	A93	Sample013	Sample source:blood | Treatment:AAC+Ex	RAW_FILE_NAME(Raw file name)=Danyan Xu-Sample013.mzML
SUBJECT_SAMPLE_FACTORS           	A94	Sample014	Sample source:blood | Treatment:SHAM	RAW_FILE_NAME(Raw file name)=Danyan Xu-Sample014.mzML
SUBJECT_SAMPLE_FACTORS           	D9	Sample015	Sample source:blood | Treatment:AAC+Ex	RAW_FILE_NAME(Raw file name)=Danyan Xu-Sample015.mzML
SUBJECT_SAMPLE_FACTORS           	D11	Sample016	Sample source:blood | Treatment:AAC+Ex	RAW_FILE_NAME(Raw file name)=Danyan Xu-Sample016.mzML
SUBJECT_SAMPLE_FACTORS           	D12	Sample017	Sample source:blood | Treatment:AAC	RAW_FILE_NAME(Raw file name)=Danyan Xu-Sample017.mzML
SUBJECT_SAMPLE_FACTORS           	D14	Sample018	Sample source:blood | Treatment:AAC+Ex+AAV-sEH	RAW_FILE_NAME(Raw file name)=Danyan Xu-Sample018.mzML
SUBJECT_SAMPLE_FACTORS           	D64	Sample019	Sample source:blood | Treatment:AAC	RAW_FILE_NAME(Raw file name)=Danyan Xu-Sample019.mzML
SUBJECT_SAMPLE_FACTORS           	D65	Sample020	Sample source:blood | Treatment:AAC	RAW_FILE_NAME(Raw file name)=Danyan Xu-Sample020.mzML
SUBJECT_SAMPLE_FACTORS           	E1	Sample021	Sample source:blood | Treatment:AAC+TPPU	RAW_FILE_NAME(Raw file name)=Danyan Xu-Sample021.mzML
SUBJECT_SAMPLE_FACTORS           	T1	Sample022	Sample source:blood | Treatment:AAC+Ex	RAW_FILE_NAME(Raw file name)=Danyan Xu-Sample022.mzML
SUBJECT_SAMPLE_FACTORS           	T2	Sample023	Sample source:blood | Treatment:AAC+TPPU	RAW_FILE_NAME(Raw file name)=Danyan Xu-Sample023.mzML
SUBJECT_SAMPLE_FACTORS           	T3	Sample024	Sample source:blood | Treatment:AAC+Ex	RAW_FILE_NAME(Raw file name)=Danyan Xu-Sample024.mzML
SUBJECT_SAMPLE_FACTORS           	T4	Sample025	Sample source:blood | Treatment:AAC+TPPU	RAW_FILE_NAME(Raw file name)=Danyan Xu-Sample025.mzML
SUBJECT_SAMPLE_FACTORS           	S1	Sample026	Sample source:blood | Treatment:AAC	RAW_FILE_NAME(Raw file name)=Danyan Xu-Sample026.mzML
SUBJECT_SAMPLE_FACTORS           	S2	Sample027	Sample source:blood | Treatment:AAC	RAW_FILE_NAME(Raw file name)=Danyan Xu-Sample027.mzML
SUBJECT_SAMPLE_FACTORS           	S3	Sample028	Sample source:blood | Treatment:AAC+Ex+AAV-sEH	RAW_FILE_NAME(Raw file name)=Danyan Xu-Sample028.mzML
SUBJECT_SAMPLE_FACTORS           	S4	Sample029	Sample source:blood | Treatment:AAC	RAW_FILE_NAME(Raw file name)=Danyan Xu-Sample029.mzML
SUBJECT_SAMPLE_FACTORS           	S5	Sample030	Sample source:blood | Treatment:SHAM	RAW_FILE_NAME(Raw file name)=Danyan Xu-Sample030.mzML
SUBJECT_SAMPLE_FACTORS           	S6	Sample031	Sample source:blood | Treatment:SHAM	RAW_FILE_NAME(Raw file name)=Danyan Xu-Sample031.mzML
SUBJECT_SAMPLE_FACTORS           	S7	Sample032	Sample source:blood | Treatment:SHAM	RAW_FILE_NAME(Raw file name)=Danyan Xu-Sample032.mzML
#COLLECTION
CO:COLLECTION_SUMMARY            	Fresh blood samples were collected from mice and transferred into 1.5 ml
CO:COLLECTION_SUMMARY            	Eppendorf tubes pre-rinsed with 1% heparin. Samples were then centrifuged at
CO:COLLECTION_SUMMARY            	4°C and 3,000 rpm for 15 minutes using a refrigerated centrifuge. The
CO:COLLECTION_SUMMARY            	supernatant (plasma) was carefully aliquoted and immediately frozen at -80°C.
CO:COLLECTION_SUMMARY            	All procedures were performed with samples wrapped in aluminum foil to prevent
CO:COLLECTION_SUMMARY            	light exposure.
CO:SAMPLE_TYPE                   	Blood (plasma)
#TREATMENT
TR:TREATMENT_SUMMARY             	The plasma collected for subsequent detection primarily includes samples from
TR:TREATMENT_SUMMARY             	the following treatment groups: (1) SHAM group: Plasma derived from mice that
TR:TREATMENT_SUMMARY             	underwent sham surgery without any intervention; (2) AAC group: Plasma derived
TR:TREATMENT_SUMMARY             	from mice subjected to abdominal aortic constriction (AAC) to induce a
TR:TREATMENT_SUMMARY             	pressure-overload myocardial hypertrophy model；（3）AAC+Ex group: Plasma
TR:TREATMENT_SUMMARY             	derived from mice that underwent AAC surgery and were then subjected to
TR:TREATMENT_SUMMARY             	moderate-intensity aerobic exercise; (4) AAC+TPPU group: Plasma derived from
TR:TREATMENT_SUMMARY             	mice that underwent AAC surgery and were administered 10 mg/L
TR:TREATMENT_SUMMARY             	1-trifluoromethoxyphenyl-3-(1-propionylpiperidin-4-yl) urea (TPPU) in drinking
TR:TREATMENT_SUMMARY             	water; (5) AAC+Ex+AAV-sEH group: Plasma derived from mice that underwent AAC
TR:TREATMENT_SUMMARY             	surgery, were subjected to moderate-intensity aerobic exercise, and concurrently
TR:TREATMENT_SUMMARY             	received an intraperitoneal injection of AAV-soluble epoxide hydrolase (sEH).
#SAMPLEPREP
SP:SAMPLEPREP_SUMMARY            	Sample preparation was performed using a solid-phase extraction unit connected
SP:SAMPLEPREP_SUMMARY            	to an HLB column, and plasma samples pre-spiked with internal standards were
SP:SAMPLEPREP_SUMMARY            	adsorbed over the column using 5% methanol after activation with ethyl acetate
SP:SAMPLEPREP_SUMMARY            	and methanol, and subsequently extracted using methanol and ethyl acetate after
SP:SAMPLEPREP_SUMMARY            	vacuum drying. The obtained samples were dried under nitrogen and re-solubilized
SP:SAMPLEPREP_SUMMARY            	using 30% acetonitrile on the machine.
SP:PROCESSING_METHOD             	solid-phase extraction
SP:PROCESSING_STORAGE_CONDITIONS 	-80℃
SP:EXTRACTION_METHOD             	quantitative 200ul of plasma were taken, and 1 μl of the mixed eico-IS was
SP:EXTRACTION_METHOD             	added to each sample, followed by connecting a Waters HLB 3 cc (60 mg)
SP:EXTRACTION_METHOD             	extraction cartridge to a solid-phase extraction device (Supelco, USA). The
SP:EXTRACTION_METHOD             	extraction procedure involved passing 2 ml of ethyl acetate through the
SP:EXTRACTION_METHOD             	cartridge, then passing 2 ml of methanol through the cartridge, followed by 2 ml
SP:EXTRACTION_METHOD             	of 5% methanol (containing 0.1% acetic acid), and 2 ml of supernatant, and again
SP:EXTRACTION_METHOD             	passing 2 ml of 5% methanol (containing 0.1% acetic acid) through the cartridge.
SP:EXTRACTION_METHOD             	The samples were then dried under vacuum for 15 minutes. A new 2 ml EP tube was
SP:EXTRACTION_METHOD             	prepared for sample collection, 0.6 ml of methanol and 1.4 ml of ethyl acetate
SP:EXTRACTION_METHOD             	were added through the cartridge. The organic phase was then evaporated to
SP:EXTRACTION_METHOD             	dryness under a stream of high purity nitrogen. Following this, 100 μl of 30%
SP:EXTRACTION_METHOD             	acetonitrile was added and vortexed 10 min for re-dissolution. After vigorous
SP:EXTRACTION_METHOD             	mixing, samples were filtered by use of centrifuge tube filters (nylon membrane,
SP:EXTRACTION_METHOD             	0.22 μm).
SP:EXTRACT_ENRICHMENT            	resuspension using 100ul 30% acetonitrile after nitrogen dried
SP:EXTRACT_CLEANUP               	filtration with 0.22um nylon filter membrane
SP:EXTRACT_STORAGE               	-80℃
SP:SAMPLE_RESUSPENSION           	resuspension using 100ul 30% acetonitrile after nitrogen dried
SP:SAMPLE_DERIVATIZATION         	no
SP:SAMPLE_SPIKING                	The internal standard consisted of a mixture of 6-keto-PGF1a-d4, PGE2-d4,
SP:SAMPLE_SPIKING                	LTB4-d4, 11,12-DHET-d11, 20-HETE-d6, 8,9-EET-d11, 5-HETE-d8, ARA-d8, DHA-d5,
SP:SAMPLE_SPIKING                	EPA-d5, and 9-HoDE-d4, each at a concentration of 5 ng/uL (Cayman, USA).
#CHROMATOGRAPHY
CH:CHROMATOGRAPHY_SUMMARY        	Solvent A: triple distilled water containing 0.02% acetic acid; Solvent B:
CH:CHROMATOGRAPHY_SUMMARY        	acetonitrile
CH:CHROMATOGRAPHY_TYPE           	HILIC
CH:INSTRUMENT_NAME               	Acquity UPLC
CH:COLUMN_NAME                   	Waters ACQUITY UPLC BEH Amide (50 x 2.1mm,1.7um)
CH:SOLVENT_A                     	100% water; 0.02% acetic acid
CH:SOLVENT_B                     	100% acetonitrile
CH:FLOW_GRADIENT                 	0–3 min, 30% B; 3-20 min, 30%–60% B; 20–24 min, 60%–80% B; 24–27 min,
CH:FLOW_GRADIENT                 	80% B; 27–29 min, 80%–30% B; and 29-30 min, 30% B.
CH:FLOW_RATE                     	0.25mL/min
CH:COLUMN_TEMPERATURE            	25
#ANALYSIS
AN:ANALYSIS_TYPE                 	MS
#MS
MS:INSTRUMENT_NAME               	ABI Sciex 5500 QTrap
MS:INSTRUMENT_TYPE               	Triple quadrupole
MS:MS_TYPE                       	ESI
MS:ION_MODE                      	NEGATIVE
MS:MS_COMMENTS                   	The dwell time was 25 ms. CUR = 40 psi, GS1 = 30 psi, GS2 =30 psi, IS = -4500 V,
MS:MS_COMMENTS                   	CAD = MEDIUM, and TEMP = 500 °C. UPLC-MS/MS raw data were disposed by Analyst
MS:MS_COMMENTS                   	1.6. Analytes was quantified by using MultiQuant 3.0.2.
#MS_METABOLITE_DATA
MS_METABOLITE_DATA:UNITS	ng/ml
MS_METABOLITE_DATA_START
Samples	Sample001	Sample002	Sample003	Sample004	Sample005	Sample006	Sample007	Sample008	Sample009	Sample010	Sample011	Sample012	Sample013	Sample014	Sample015	Sample016	Sample017	Sample018	Sample019	Sample020	Sample021	Sample022	Sample023	Sample024	Sample025	Sample026	Sample027	Sample028	Sample029	Sample030	Sample031	Sample032
Factors	Sample source:blood | Treatment:AAC+Ex+AAV-sEH	Sample source:blood | Treatment:SHAM	Sample source:blood | Treatment:AAC+Ex	Sample source:blood | Treatment:AAC+TPPU	Sample source:blood | Treatment:AAC+Ex+AAV-sEH	Sample source:blood | Treatment:AAC+Ex	Sample source:blood | Treatment:SHAM	Sample source:blood | Treatment:AAC	Sample source:blood | Treatment:AAC+TPPU	Sample source:blood | Treatment:SHAM	Sample source:blood | Treatment:AAC+TPPU	Sample source:blood | Treatment:AAC+TPPU	Sample source:blood | Treatment:AAC+Ex	Sample source:blood | Treatment:SHAM	Sample source:blood | Treatment:AAC+Ex	Sample source:blood | Treatment:AAC+Ex	Sample source:blood | Treatment:AAC	Sample source:blood | Treatment:AAC+Ex+AAV-sEH	Sample source:blood | Treatment:AAC	Sample source:blood | Treatment:AAC	Sample source:blood | Treatment:AAC+TPPU	Sample source:blood | Treatment:AAC+Ex	Sample source:blood | Treatment:AAC+TPPU	Sample source:blood | Treatment:AAC+Ex	Sample source:blood | Treatment:AAC+TPPU	Sample source:blood | Treatment:AAC	Sample source:blood | Treatment:AAC	Sample source:blood | Treatment:AAC+Ex+AAV-sEH	Sample source:blood | Treatment:AAC	Sample source:blood | Treatment:SHAM	Sample source:blood | Treatment:SHAM	Sample source:blood | Treatment:SHAM
AA	860.9053397	1649.199877	2909.440019	4738.188906	6734.081371	6035.038302	6016.947175	4972.364613	8489.057814	9502.92516	8875.034428	7342.791279	12294.81989	10500.10822	11844.69183	10318.37338	10771.1477	9575.127764	13301.39981	13782.50964	12194.97206	11266.06692	13655.9587	15358.50366	14288.00711	420.7092283	674.9357762	873.9443014	7565.490043	4479.05231	6121.979592	6565.620867
15d-PGJ2	0.451186366	0.257967422	0.281961867	0.352121147	0.382121865	0.277177834	0.024512891	0.045489328	0.256448292	0.307750868	0.421848065	0.459161185	0.932796974	0.675285385	0.074514155	0.114195998	0.01747568	0.032881332	0.04309291	0.041696097	0.232493194	0.875098785	0.983507847	0.467098913	0.627746877	0.408178275	0.063010215	0.239353404	0.19807214	0.435417406	0.197221309	0.276429358
6k-PGF1a	0.014783679	0.018060722	0.026577238	0.013680439	0.011405922	0.011825227	0.007213447	0.006359531	0.016466357	0.018705375	0.021646646	0.013277227	0.006800847	0.013703683	0.008300709	0.005478618	0.008453574	0.005527616	0.006315856	0.006885684	0.020988353	0.009965865	0.013968104	0.03026849	0.015851245	0.007963187	0.003847449	0.002694277	0.01043209	0.014897104	0.010199509	0.00509477
PGD2	11.26774319	7.018187822	7.83218011	7.097586166	9.041909786	9.761355685	1.547467704	1.938185966	5.800464425	6.423483877	7.838163224	11.37746209	8.340432187	7.380959243	1.901715481	1.018819911	1.104381101	1.178933892	1.426898453	1.224219821	5.849093172	6.654174378	9.310242997	5.187496884	5.697619864	3.074322443	1.096736006	1.98758285	1.069351147	4.593703672	2.718076797	1.327099816
PGE2	9.17501082	3.69137859	4.231472904	4.388338685	6.401308747	8.787624423	0.415039997	1.005537383	3.276193651	4.278317837	4.465045366	7.852874521	10.16834916	6.656881172	0.637951627	0.712526242	0.727360482	0.547120719	0.838892231	0.642082499	3.440941481	6.825423218	11.16176009	6.726188285	5.962062282	4.713281494	0.358586604	1.856112015	1.395401417	3.676680678	1.749184886	1.329953552
PGF2a	1.14216458	1.89683198	1.846391086	1.709387969	0.963766035	1.597341178	0.366680286	2.362889972	1.952650956	1.406023267	1.258946606	1.620397904	2.376892398	1.910937161	0.269945274	0.359953403	0.197290257	0.258997361	0.402073402	0.696144841	1.747320571	2.092994183	3.1300828	3.215575128	1.642570398	0.614756864	0.484754575	0.429510128	2.801196319	0.866145903	1.312796895	0.463257656
PGJ2	NA	0.056883396	0.041807069	NA	NA	NA	NA	0.049989223	0.044524784	0.035436377	0.02393914	NA	NA	0.029835776	0.026454235	NA	0.022615986	0.021676678	NA	0.045671709	0.042747477	NA	NA	NA	NA	NA	0.061968042	0.014821859	0.101640356	0.045193312	0.038337005	0.034703175
TXB2	9.302491003	51.13502345	29.55616563	41.184526	4.90161509	7.722685687	6.277766648	30.04772274	40.58324195	22.68770216	20.97577288	17.82233564	8.862148041	12.84960055	2.950146403	4.825082972	2.87920526	1.496183904	3.232630782	2.943324597	31.28750904	6.516321067	11.06512071	25.66014065	8.755794419	4.221429691	3.865238857	3.187438925	3.565051888	7.872416665	27.31367415	4.924918489
11-HETE	6.872748148	11.91802799	11.0874041	11.7730071	9.12729813	10.74321961	2.82548974	5.900319299	10.84533716	10.93344006	13.1625975	17.4451203	14.11503863	17.54156815	4.415056422	1.931395612	1.487395231	1.366567231	1.631185125	1.551048168	10.95838746	10.85310426	17.91563808	12.8346479	9.603401728	2.580994844	1.176196023	3.528184083	2.272863257	6.208432704	7.953500457	2.567673674
12-HETE	58.1900692	315.7542597	236.1902336	311.8527362	70.60493717	63.93148604	82.92436081	390.6149906	334.2009105	209.9517898	237.8425873	206.835634	100.3994079	159.8423581	116.0783586	45.67423413	37.58932598	53.07088711	148.1561537	169.2554275	295.9538962	145.0129152	163.0136173	327.7883636	90.27006516	18.31119133	42.26347543	40.0544339	47.38320261	89.59570268	207.6873807	64.71026161
15-HETE	28.67387829	32.80648867	31.52291052	26.24847741	36.75940645	43.59329511	6.207131139	6.730282438	22.89378395	33.34068933	40.71268011	53.68046271	51.63705114	48.52515823	9.706712163	5.28194355	3.27657213	3.59774572	5.137839851	3.630840333	21.49020719	40.60980821	57.46351155	30.93909312	35.57211693	9.468870074	2.432500964	10.79317166	5.904388291	20.33273679	17.87719232	8.067648181
15-oxo-ETE	14.10306249	11.77072795	13.18441619	10.34829149	15.56354178	16.50760905	2.796441847	0.867881136	7.077577612	12.09897961	12.17424533	18.81554651	33.42409472	29.99571867	4.292069328	3.247301912	1.462506501	2.060027226	3.221047834	1.542419948	5.933311868	24.50904395	42.07025973	13.66522904	19.06893412	4.774165082	1.342931783	5.326938375	2.839641338	9.068357446	5.16582087	3.522540567
5-HETE	26.42285635	27.06309589	28.57985358	24.13762033	36.87643864	37.90477554	6.569810772	4.403305679	17.52913648	29.66441431	28.27648383	46.22535318	46.20079055	38.87150309	9.098856735	6.468040305	3.516337762	4.809965329	5.758291168	4.100885007	17.50304222	26.97108821	52.1790734	30.58943766	29.44191386	9.990364756	3.705081638	11.94539881	9.055378318	22.73275366	15.01480612	8.367344773
5-oxo-ETE	11.06474433	9.46096898	8.704834245	7.28187047	13.6949868	13.04282695	3.038243932	1.471832688	5.823221591	9.452466406	9.496336437	14.16982962	22.25213694	13.22568141	4.680342577	5.682501102	1.652263661	2.168512122	5.672553193	1.559277717	7.422216605	18.9703215	27.84577228	14.30160212	8.813872434	6.503421545	1.462498654	4.962429648	4.397236999	9.343002655	5.692637699	5.023248289
8-HETE	2.595135593	5.066866852	4.19337613	4.090468223	3.139441475	3.001295889	1.083558101	2.728754012	4.226745185	3.762398483	5.165293699	5.937577515	4.424383184	4.68813695	2.310740379	0.802821373	0.786568668	0.934046235	1.434352565	2.105719777	3.332316961	3.554050571	6.115047023	5.27860284	3.373444996	1.167302305	0.621853015	1.610592342	1.25034152	2.843807103	2.529270312	1.339585554
9-HETE	4.604308653	5.923728717	6.212556738	4.333086833	5.543199744	6.702045284	1.030207766	1.031025084	4.750994818	5.302273413	7.208719387	9.811035773	8.078691161	8.110212221	2.441282159	0.696297336	0.676593005	1.002711864	1.050830663	0.582958993	4.195776375	4.912022129	10.43782806	6.537359549	5.600106708	1.712723111	0.399995264	1.649758466	0.948523473	3.786833815	2.981776594	1.065165024
LTB4	2.110862193	2.809370358	2.34121946	2.775960892	1.566391176	1.754550944	0.047767735	0.214579289	2.257356367	2.844462554	1.903342782	3.991476428	2.373869128	2.273905646	0.409478327	0.213785095	0.115106791	0.140954609	0.703348866	0.206504859	3.112631194	1.634379381	4.532119866	4.050301909	1.522327923	0.783124091	0.135663517	0.44685889	0.357277005	1.36543345	1.793250107	0.422132589
11,12 DHET	0.32964203	0.324563436	0.288636097	0.259312831	0.547512122	0.349510795	0.18023666	0.219572108	0.24939912	0.29413579	0.338269038	0.370010138	0.420807704	0.367089432	0.416739102	0.248572943	0.220134731	0.472710356	0.199114746	0.579814045	0.308129576	0.344091636	0.376518594	0.339365967	0.272258136	0.1960858	0.193332498	0.279586759	0.304631804	0.275351024	0.278531377	0.243640814
11,12-EET	3.604879153	5.820920648	6.361403414	4.900313466	4.038647817	5.044466965	1.469131759	1.029515074	4.966065376	5.316361895	8.08493955	11.57337827	7.078491957	5.872113122	3.216671042	1.047614489	0.884302106	1.09978624	0.810343161	0.71566337	4.785285214	6.750984918	6.15595467	9.41643425	5.763995688	1.185967707	0.630454511	1.501251977	1.087551658	2.799531735	2.451410165	1.29215952
14,15 DHET	0.320441221	0.511477398	0.256243531	0.346500356	0.648713251	0.491512745	0.256851767	0.240241875	0.25479848	0.391638416	0.470952252	0.403077263	0.274403054	0.545539872	0.72270122	0.449355834	0.329742035	0.808431566	0.403618573	1.311705225	0.349301767	0.233346704	0.272551521	0.304658719	0.262720256	0.35446059	0.368316637	0.490584699	0.590943806	0.514212189	0.508028861	0.476741907
14,15-EET	5.351363175	8.151843803	8.624717431	6.875986927	5.80816075	7.036978692	3.448143237	3.735435475	7.61494475	7.637459515	11.62477536	12.89514027	9.885180437	8.521059955	5.844743105	1.788679582	1.906707395	2.496187661	2.59017987	2.173289403	7.608318773	10.14682499	10.72493441	12.52880732	8.030058197	1.92304273	1.0351332	2.792502422	2.307045478	5.114343306	3.052808813	2.205500612
16-HETE	1.53587823	1.236494713	1.276517309	0.942113944	1.191158346	1.293031357	0.119809291	0.132883251	0.599674852	1.107963064	1.181288915	1.789359265	1.455695967	1.212704754	0.572494307	0.28385308	0.150305297	0.175948363	0.166082858	0.18555207	0.657975341	1.092912906	2.129304106	1.658835916	1.073734119	0.723201747	0.08211802	0.301900807	0.339308214	0.619676799	0.67924648	0.247023977
18-HETE	0.262457073	0.494780624	0.329418764	0.337612405	0.664317904	0.509852599	0.452222552	0.289929125	0.301159339	0.322275005	0.437094787	0.513796287	0.313923252	0.494025398	0.582517235	0.48553983	0.158118651	0.244308795	0.281064734	0.713982755	0.336796555	0.318796689	0.380423192	0.469463312	0.434070352	0.360462257	0.319884393	0.421025756	0.45322174	0.29821765	0.447223098	0.291381285
19-HETE	NA	NA	NA	NA	NA	NA	NA	1.13104033	NA	NA	NA	NA	1.806830771	2.840821132	1.807650651	1.400368293	NA	1.315315984	NA	2.26781481	1.043381242	0.744186406	2.142876473	1.220340861	NA	NA	NA	0.644935648	1.276926107	0.960136835	0.781387633	0.608590004
5,6 DHET	0.235645963	0.213766006	0.143134286	0.108317097	0.307420328	0.25404777	0.171928856	0.183418077	0.260930834	0.176726978	0.197708178	0.122001206	0.159111919	0.20531622	0.31769584	0.246478626	0.249415376	0.277703241	0.289512737	0.464681908	0.254253172	0.170654555	0.21401722	0.176052879	0.119882447	0.237665925	0.169781655	0.264590575	0.265313138	0.229287304	0.262353349	0.225736183
5,6-EET	8.187157157	14.86374614	16.78814553	11.61263036	8.725001766	10.32516211	2.630447469	1.623453478	11.71335003	9.816087237	15.19946809	22.24413372	12.41452639	9.887494807	5.164395886	1.356521875	1.599280604	1.746387805	1.741342019	1.264886766	5.606382157	9.495139191	9.316088825	7.956620782	8.085659859	1.663794816	0.550438482	1.804942461	0.773324604	3.158828827	0.823153729	1.407777312
8,9 DHET	0.450614574	0.362806363	0.306540696	0.351345272	0.938940479	0.625717086	0.343111333	0.415939288	0.285638329	0.440870832	0.386623323	0.406534265	0.324351968	0.372608435	0.794449855	0.375001454	0.719415802	0.79120112	0.62904606	0.999423381	0.506803138	0.38091114	0.452915939	0.499939877	0.387188608	0.297969256	0.289668683	0.330106167	0.474947048	0.374137575	0.490532472	0.443699899
8,9-EET	5.171926975	7.946192181	8.619443347	6.444064873	5.767755437	7.809066326	2.282456095	1.764481828	6.183402792	7.024229939	9.702737461	13.98331374	10.21263201	7.517036252	4.753173386	1.44410927	1.393002962	1.516847223	1.583785385	1.166531556	7.96277421	9.048736812	10.18504739	13.54780001	6.880568759	2.014200339	1.094336741	2.532817517	1.865228516	4.397363559	3.665088743	1.982655624
DHA	906.9198528	2490.954233	6232.2463	10364.42689	13714.55376	14433.63927	21762.68582	12852.28006	23942.47768	25327.62392	18812.97978	17373.04323	28796.94062	23597.58954	51657.79879	20187.6434	21848.07708	18726.38304	24130.21651	22883.91621	51569.96729	41662.53988	46327.69418	46834.0341	40882.24517	681.5403979	1671.810899	1782.663	19241.60386	7610.156622	10824.73809	13268.60438
10-HDoHE	1.912704712	3.771104041	2.890164516	2.934652897	2.947471806	3.139606639	1.001035	1.679564602	2.258706046	3.34569307	4.498380072	4.53080449	4.50205338	4.763962283	2.203994123	0.547447026	0.526161413	0.744566591	0.674250436	0.559869182	3.470925866	4.450379147	4.487409089	3.698962768	3.281583734	0.959542162	0.645148331	1.595664814	1.109384076	2.20834722	1.533030731	1.272717251
11-HDoHE	1.8613918	2.781677114	2.195953995	2.121779068	2.787299135	2.473794765	0.705317548	0.35241543	1.567752519	3.000093292	3.41590085	3.326318806	3.338724406	3.753986258	1.340009546	0.478142939	0.287449083	0.359756817	0.30219321	0.250214227	2.661567916	3.038461489	4.347374892	2.618866928	2.748693843	0.967431658	0.482481005	1.386255386	0.748152955	1.711501678	1.20341908	0.874691415
13-HDoHE	1.999397233	3.980437669	2.504454219	3.243089313	4.204472998	4.625926848	1.371168442	0.772283641	2.111558742	3.274417244	4.02968759	5.122496797	5.204244181	5.560641539	2.301706557	0.418121464	0.607200234	0.514386688	0.461941425	0.551811851	3.929732303	4.420203533	4.418480829	4.065749597	4.136681246	1.184259567	0.411425885	1.557438392	1.236159472	2.604804468	1.480725133	1.296766111
14-HDoHE	6.053342169	27.00968718	20.09276583	21.38546867	9.371142499	9.355967618	9.606908052	63.69801781	29.50329378	15.03489082	26.10373163	18.82792793	15.52181461	20.4508406	17.81044415	3.296819808	4.170632429	5.145235953	10.67299157	15.95244493	34.70772972	19.19883316	20.42064314	38.70657747	14.91966497	2.768679643	6.549634054	7.117467236	6.155297587	9.57611332	14.99964286	6.795580414
17-HDoHE	5.167222459	10.0548635	9.340509888	8.42926038	10.2576809	7.75514519	2.858011649	4.735828504	7.371894442	8.585520519	12.22452552	15.97066713	13.76532774	15.45536523	5.178259523	1.530622277	1.555553879	1.966878274	1.921163173	0.968749604	9.776917484	7.974070295	12.34964449	9.514262114	7.388600161	3.331292129	1.207536995	5.117900684	4.138569558	7.099722442	4.999272128	4.166965579
20-HDoHE	15.31573993	24.33747537	22.29956018	18.11585454	25.73854676	26.06666761	4.609387075	2.223995614	14.50298103	20.41536715	25.6655533	32.94115488	34.73688206	38.90742152	10.28788953	2.497111604	1.984408093	2.521678916	2.390653606	1.958418077	22.40453044	32.6284898	33.09153575	23.39659665	25.70160551	8.724669719	2.605152992	10.3389634	7.078709783	19.07555538	10.13577421	7.988502838
4-HDoHE	22.1711071	20.58967736	21.53653687	18.54150462	35.46101551	35.06712497	7.385185496	3.257206624	11.72531906	24.73611034	19.98652116	35.29105395	51.14036791	43.17935385	8.863521215	5.038768858	4.529037726	4.93389407	5.668756725	2.549069009	20.56754326	33.59513813	45.22979222	27.65320816	26.72995867	11.79618673	4.937224206	14.40642695	13.64697281	27.9463831	15.27089671	15.15150339
6R-LXA4	9.732743478	10.28406322	9.663146948	8.172061647	7.280415906	18.23968414	0.106484896	0.219115278	4.965145858	4.044608823	7.653483028	20.71675048	15.61006398	13.30795492	1.6128093	0.848804171	0.527994978	0.651823299	1.029212191	0.439948769	5.372893603	13.29761045	18.86139315	8.694489596	12.64353335	2.765537557	0.158924996	2.356444348	0.603083115	5.567298773	1.301289774	1.281272946
7-HDoHE	2.261061246	3.998698148	4.01800775	3.268913155	3.386024656	3.531331333	1.266155618	0.816120201	2.663006038	2.828806459	4.484625206	5.228534013	4.603380157	6.194256801	2.411316293	0.683436712	0.790868422	0.645535394	0.685952197	0.39968344	3.730721115	4.927890764	5.225782773	4.343448111	4.285616804	1.302319295	0.600745837	2.153137012	1.371709759	2.97779276	2.383497271	1.503242061
8-HDoHE	4.567978245	8.690467784	7.758453684	7.657805295	9.192210641	9.824799748	2.564077901	1.943599671	5.916098127	7.514618047	10.12498841	12.23036235	11.14571739	12.30599389	3.504549177	1.554517396	1.313942096	1.418976926	1.178566485	1.533341584	7.831756005	9.663820494	14.20363849	11.27365457	8.537872969	3.068872457	2.176585406	5.852359775	4.050975969	7.06848069	4.772313147	3.924379292
16,17-EDP	1.659140469	3.336478499	2.813335615	2.78749089	3.334253239	2.885729254	1.048211948	1.011344296	2.410475046	3.516031214	5.001693085	5.481047727	4.349707447	4.348063157	3.064907747	0.663877035	0.545848165	0.553433608	0.89271719	0.464058295	4.276631019	5.905923736	4.122937815	4.792923511	3.804157779	1.386218129	0.592224905	1.859135444	1.514337102	3.603355728	1.978812495	1.915362888
19,20-EDP	11.88150155	21.0511941	19.71490271	23.13766887	29.51337893	22.97972862	4.65831852	3.327926179	16.77505027	22.45685064	34.71166359	35.4210605	34.21391546	36.56757719	17.79530777	4.054622131	2.875831002	3.756040427	5.312432658	3.558346936	30.67204332	43.89835542	33.97227867	29.68977506	26.50278023	11.5054742	2.938474811	14.1278993	9.009819786	23.35895332	13.98640494	11.86034234
DPA	3.365448616	8.714547097	18.75389273	29.45817414	39.10102622	43.74339624	48.75155803	33.18717217	62.5261202	77.0484332	76.36916522	51.29302055	109.8122453	80.70826629	136.7051027	87.16348821	62.83711523	39.02274913	61.96494594	83.67914839	98.1483392	92.29311694	161.5187244	147.5079438	126.2036966	1.532653128	3.959267257	3.854147682	77.63264061	17.86922087	40.30812937	32.61403764
EPA	95.78683432	237.4778149	378.2967308	554.5978068	490.562029	376.6581999	610.424735	834.8754407	773.8453271	697.095481	959.9907132	1228.174089	1145.147847	1167.598481	512.9485173	505.2251699	282.6742091	256.3396876	364.2018789	347.1679481	741.1500792	894.929534	1108.236588	1110.681276	1082.439207	82.0926644	159.6183173	215.6836948	794.6015237	617.2979911	674.8653461	703.6610567
TXB3	0.142230737	0.10545324	0.077102559	0.084600034	0.110705541	0.129692694	0.046907866	0.132814321	0.144596108	0.120563396	0.164015289	0.044669469	0.07977816	0.108337953	0.019113316	0.018757322	0.024192594	0.025598346	0.036286953	0.022804439	0.091560087	0.101303798	0.066878218	0.143743773	0.12503526	0.079054747	0.0461177	0.027867273	0.029204274	0.065454047	0.109588418	0.035075292
11-HEPE	1.133393739	2.057261439	1.547639694	1.405279605	0.976253935	1.503894627	0.274415317	0.246203747	1.233807267	1.286645745	1.873539603	2.628620901	2.251858263	2.869775236	0.468915098	0.144472208	0.078826317	0.143007142	0.106774387	0.11100458	0.881066371	1.983014687	2.597750706	1.718393474	2.052858186	0.524759577	0.310705953	0.831121222	0.498861515	1.154403134	0.865074687	0.557121503
12-HEPE	3.88323872	21.95685311	21.7086305	25.36263171	3.926412578	3.190535901	6.453961374	53.89517914	15.41776991	11.50342431	20.37360522	15.84530486	10.56224915	16.82842058	8.591514759	1.261774866	1.179860621	1.411376937	6.343694304	7.511686924	31.88609219	10.7385087	14.43471885	34.81328661	8.141912589	1.105292368	2.34245746	2.644352912	3.905661932	3.931030589	9.257555533	3.599527553
15-HEPE	1.329965815	1.998273805	2.184752909	1.47042797	1.20714355	1.91047075	0.557767863	0.463068019	1.51588184	1.355901163	2.132426258	2.135627737	2.58685124	3.422360279	0.408563617	0.155754122	0.140870897	0.097371286	0.09216014	0.163023852	1.492509616	2.501904053	2.883746761	2.224651188	2.799858854	0.566316513	0.42913025	1.250646595	0.668019433	1.301582253	1.043521657	0.639661697
5-HEPE	5.740156537	10.14494895	9.248161912	8.45289616	6.22868118	6.844885254	2.056096186	2.207319717	5.862981522	6.968569466	10.95059354	14.36993743	15.09527183	15.12942874	2.552567252	1.311899182	0.392654783	0.683935033	0.783835306	0.644823012	4.636799657	11.70576263	13.95950013	7.986386142	10.98075813	3.15299875	2.267095175	5.732360947	4.387000852	6.585872658	5.155464249	3.752445783
9-HEPE	1.300186049	3.756817655	3.553146837	3.528240337	1.369865518	1.446332034	0.930140529	4.356273154	2.871200692	2.181402199	4.115309909	5.095479583	4.033192231	4.879361001	1.31597965	0.312729429	0.228969739	0.139564097	0.885758088	0.551810036	3.662938999	2.972471285	4.475257657	4.75275938	3.164085894	0.522420625	0.728217178	1.322362406	0.93625224	1.355432013	1.89350512	0.881795946
11,12-EEQ	0.652950287	2.23225087	1.826950923	1.242479066	0.556220488	0.883209297	0.316145764	0.410960233	1.076136879	1.088790759	2.916529805	3.180223385	1.848874811	2.183617335	0.866122326	0.186712817	0.091878882	0.11033084	0.071754542	0.309274829	0.982780873	2.464843888	1.777128868	2.037797634	1.897153387	0.346197581	0.136430767	0.467148728	0.379756786	0.711397521	0.57559101	0.356709294
14,15-DiHETE	0.720744012	1.843410525	1.492257882	1.22738392	1.041219634	2.100180097	1.364570437	1.688863463	2.564014	1.121949294	0.821134515	1.423337853	1.305801965	1.292462055	1.027394693	1.330073255	0.444581318	1.243405957	0.364398141	0.989718841	2.063114205	1.333136389	0.992773112	1.215720974	1.496393458	1.441185863	2.096594453	2.252927814	2.078108573	1.4873114	1.917214482	2.298935933
14,15-EEQ	0.758501994	1.982180589	1.404825947	1.167944519	0.637037739	0.847135415	0.443494244	0.597144369	1.294487935	1.417532127	2.252324577	3.550015448	2.069602059	2.189742685	0.642780889	0.142132637	0.140378551	0.091765583	0.137964077	0.064737025	1.209001757	2.976971217	1.627892327	1.842389226	1.990669047	0.402142785	0.136686852	0.60785608	0.328186585	0.83410725	0.467331823	0.371912638
17,18-DiHETE	0.30309869	0.899595592	0.523579273	0.578932022	0.760308193	0.973804144	0.631329087	0.603448236	0.704960639	0.528560842	0.451232825	0.459624154	0.496817255	0.716973779	0.939299121	0.53595528	0.346117534	0.697289306	0.261427501	0.907659072	0.68305047	0.465628646	0.356337629	0.503034142	0.498409354	0.589698148	0.694064581	0.830083807	0.921273948	0.564269729	0.894610583	0.759633356
17,18-EEQ	1.251613602	4.217539023	3.746808395	2.756132432	1.579395141	1.916184876	2.771583422	4.485418298	2.882709176	2.053645012	4.651218778	5.432130073	6.02004689	4.011065388	1.834211262	0.664223348	0.425769212	0.418637955	0.40041285	0.426516541	2.793535297	6.141909506	4.28366958	5.436273549	5.355572193	0.698595094	0.540520403	1.537885977	1.447741106	1.942274107	1.186582348	1.115362547
18-HEPE	10.95087343	18.06375815	15.46471237	11.38333843	10.18676831	11.53443325	1.696268245	1.23905576	8.026387559	13.21415849	17.82477789	22.46667493	23.79608375	30.97972638	3.081921012	1.393827841	0.825007126	0.5579306	0.920787205	0.364586295	6.745918615	19.51825497	23.90791567	12.4470237	21.0513534	6.265363703	1.997903017	8.063812943	5.495924243	12.60425057	7.292038048	5.490607147
5,6-DiHETE	0.320356632	0.986274438	0.532755412	0.373811064	0.425199491	0.58048796	0.936608281	0.796287971	1.115630562	0.457777751	0.432302751	0.446049249	0.825859939	0.326486032	0.321596275	0.265392955	0.227371301	0.358905877	0.330893117	0.236005564	0.70259093	0.515847328	0.493924257	0.987644149	0.541220888	0.610059059	0.617304384	0.811393956	0.860467257	0.621701235	1.115463931	0.714643613
5,6-EEQ	8.361285225	18.10109149	15.87729526	15.11465648	6.329449182	7.58278265	3.595739885	5.06556461	10.87152913	12.73719746	24.14565276	29.26784948	15.82479446	15.82125023	4.228446847	1.095317588	0.342798891	0.231348449	0.877117003	0.409566397	5.213577835	17.06188694	12.10487323	8.805458257	13.85436046	1.546335193	0.814872702	2.080218945	0.93129342	3.697721491	0.613013868	1.521593794
8,9-EEQ	2.172942163	4.354005798	3.860790855	2.548725483	1.303712945	1.825393084	0.676347265	0.554667658	2.357107962	2.653768961	5.283014009	6.515694001	3.442566002	3.993555375	1.089487156	0.36085827	0.517567779	0.309800467	0.401118828	0.260171488	2.265198992	4.418076121	3.034793643	3.149640271	2.710466296	0.813524481	0.256667831	0.792093806	0.69508408	1.478855623	0.991395171	0.762601056
13-HODE	1872.708661	2147.244535	2055.034966	1332.234398	1253.312768	1900.26553	281.8692925	152.7394515	1156.730914	1279.091493	1692.80672	3075.450499	2469.426033	1865.45658	673.4296822	342.8592781	83.56275599	129.0110742	166.4245585	94.33693201	1269.101151	1634.405475	2923.862807	2590.657886	1919.340411	577.78644	184.4410448	489.421318	330.2953372	622.7454675	773.8523676	312.8220931
13-oxoODE	626.1238514	739.8853726	700.4625418	417.3561163	333.7050076	603.8477165	68.69913339	20.22192053	255.5076179	340.478803	545.7717919	1116.377407	947.6584867	697.9839417	163.1386949	59.6833232	16.60922434	20.23217974	28.93028167	13.36907921	296.4772466	671.7501603	1293.919278	785.2851471	719.0639827	150.296639	21.18810206	90.60593913	57.87032929	145.9246142	133.1775746	49.1040904
9-HODE	1244.014784	1600.89436	1518.922762	1002.180327	832.7966293	1249.960374	158.1907776	59.21815128	689.2695985	863.810206	1299.833256	2272.332396	1633.783684	1289.972752	472.8523629	171.3585495	46.71040084	76.28692769	110.2036898	51.38227477	866.8358014	1055.98821	1909.18602	1591.24131	1267.716105	394.7781663	72.23482959	259.585289	181.0751532	400.432281	461.3642348	133.2802211
12,13 diHOME	25.76125027	44.23467024	34.14042748	31.80117411	24.64593264	57.50615342	8.129253145	10.46310749	63.50882209	24.8057369	14.89724176	22.11031081	14.09558195	17.48537409	53.56867357	66.72494943	4.021238217	13.3573119	12.40114532	19.9673289	33.25676648	9.499597652	8.66402376	15.75057164	8.446113647	41.49385405	40.29801225	60.80900393	34.29876833	23.34349561	34.87543751	35.64531383
12,13 EpOME	127.8027693	219.2638542	288.4219763	164.3483353	107.4140664	177.3969713	143.2039398	221.2308223	246.5507425	154.1954265	229.5813261	419.0446643	505.1369817	214.3429855	199.5759565	99.65923208	27.76396834	46.19856076	47.0765363	22.94179733	194.3922978	514.4928664	515.4796545	686.4341907	426.499318	45.89769283	40.18978609	74.56868227	63.66435679	103.3042738	68.18425196	62.82750496
9,10 diHOME	13.84550285	22.03620156	18.60533037	17.64514179	11.8581986	26.380727	6.694810133	7.835697776	40.19690055	12.3496359	7.974168897	12.75246543	11.86931808	10.93479461	30.56098887	30.26294584	2.626259619	8.130645897	7.864651609	10.14217264	18.24698331	8.493277952	11.31394121	18.53527586	9.271496213	23.53763708	22.48637606	31.85728562	19.15289439	11.7832513	18.59039786	18.75889827
9,10 EpOME	210.286049	346.0111302	432.811777	264.6877802	157.3533783	259.0246445	79.74355631	59.82227313	294.5294108	230.4105596	375.701624	676.7223856	477.6488526	307.1346645	195.1085293	68.79475229	24.30216152	35.11626544	42.00305747	19.08431322	314.8436184	442.6238211	508.4814093	752.8116615	422.8944895	64.60527941	29.52980734	80.2777433	64.58925015	123.2885884	91.08633784	63.71504608
MS_METABOLITE_DATA_END
#METABOLITES
METABOLITES_START
metabolite_name	retention index	quantified m/z
AA	259	303
15d-PGJ2	271	315
6k-PGF1a	163	369
PGD2	271	351
PGE2	271	351
PGF2a	309	353
PGJ2	189	333
TXB2	169	369
11-HETE	167	319
12-HETE	179	319
15-HETE	219	319
15-oxo-ETE	113	317
5-HETE	115	319
5-oxo-ETE	129	317
8-HETE	155	319
9-HETE	151	319
LTB4	195	335
11,12 DHET	167	337
11,12-EET	167	319
14,15 DHET	207	337
14,15-EET	219	319
16-HETE	233	319
18-HETE	261	319
19-HETE	231	319
5,6 DHET	145	337
5,6-EET	191	319
8,9 DHET	127	337
8,9-EET	155	319
DHA	229	327
10-HDoHE	153	343
11-HDoHE	121	343
13-HDoHE	193	343
14-HDoHE	205	343
17-HDoHE	245	343
20-HDoHE	241	343
4-HDoHE	101	343
6R-LXA4	115	351
7-HDoHE	141	343
8-HDoHE	109	343
16,17-EDP	274	343
19,20-EDP	299	343
DPA	231	329
EPA	257	301
TXB3	169	367
11-HEPE	167	317
12-HEPE	179	317
15-HEPE	219	317
5-HEPE	115	317
9-HEPE	149	317
11,12-EEQ	179	317
14,15-DiHETE	207	335
14,15-EEQ	207	317
17,18-DiHETE	247	335
17,18-EEQ	215	317
18-HEPE	259	317
5,6-DiHETE	145	335
5,6-EEQ	189	317
8,9-EEQ	123	317
13-HODE	195	295
13-oxoODE	113	293
9-HODE	171	295
12,13 diHOME	183	313
12,13 EpOME	195	295
9,10 diHOME	201	313
9,10 EpOME	171	295
METABOLITES_END
#END