#METABOLOMICS WORKBENCH zhouyiyang_20250804_192449 DATATRACK_ID:6251 STUDY_ID:ST004198 ANALYSIS_ID:AN006979 PROJECT_ID:PR002647
VERSION             	1
CREATED_ON             	August 8, 2025, 7:16 pm
#PROJECT
PR:PROJECT_TITLE                 	Deep Serum Multiomics Analysis Defines the Molecular Landscape and a Diagnostic
PR:PROJECT_TITLE                 	Signature of Acute Ischemic Stroke
PR:PROJECT_SUMMARY               	Acute ischemic stroke (AIS) urgently requires reliable diagnostic biomarkers to
PR:PROJECT_SUMMARY               	mitigate pre-hospital delays and enhance thrombolysis utilization. We performed
PR:PROJECT_SUMMARY               	integrated untargeted proteomic, metabolomic, and lipidomic analyses on serum
PR:PROJECT_SUMMARY               	samples from a discovery cohort (AIS patients, n=52; healthy controls [HC],
PR:PROJECT_SUMMARY               	n=50). Proteomics identified 295 differentially abundant proteins, implicating
PR:PROJECT_SUMMARY               	blood-brain barrier disruption (downregulated structural anchors: FLNA, ACTB,
PR:PROJECT_SUMMARY               	ACTN1; Rho GTPases: RAC1, CDC42), thromboinflammatory activation (upregulated
PR:PROJECT_SUMMARY               	platelet receptors: ITA2B, ITB3, GP1BA; inflammasome components: CRP, SAA) and
PR:PROJECT_SUMMARY               	complement dysregulation (C1S, C4BPA). Metabolomics and lipidomics revealed 134
PR:PROJECT_SUMMARY               	altered species, demonstrating: an energy crisis (depleted citrate cycle
PR:PROJECT_SUMMARY               	intermediates, aberrant glycolysis), oxidative stress (elevated
PR:PROJECT_SUMMARY               	glutamate/L-pyroglutamate; depleted antioxidants), and pathological lipid
PR:PROJECT_SUMMARY               	remodeling (accumulated diacylglycerols/sphingomyelins; reduced
PR:PROJECT_SUMMARY               	lysophosphatidylcholines/sterols).multiomics integration revealed that AIS
PR:PROJECT_SUMMARY               	pathogenesis involves synergistic glycolysis-triggered energy crisis,
PR:PROJECT_SUMMARY               	glutathione-dependent oxidative collapse, and catastrophic lipidome disarray.
PR:PROJECT_SUMMARY               	Machine learning (RF/LASSO) derived a diagnostic panel comprising FA9, APOC2,
PR:PROJECT_SUMMARY               	SAMP, C1S, OSTP, PCSK6, CCN2, PDGFC, HPSE, ANGL3, glutamate, glycerate, and
PR:PROJECT_SUMMARY               	succinate. This panel achieved exceptional diagnostic accuracy in an independent
PR:PROJECT_SUMMARY               	validation cohort (AIS=46, HC=48; AUC=0.998, 95% CI: 0.955-1.000), significantly
PR:PROJECT_SUMMARY               	outperforming established markers (PCSK9, succinate alone) and showing strong
PR:PROJECT_SUMMARY               	correlation with NIHSS scores. Our study establishes a mechanistically grounded,
PR:PROJECT_SUMMARY               	high-performance multiomics biomarker signature for AIS diagnosis.
PR:INSTITUTE                     	Wenzhou Medical University
PR:LAST_NAME                     	Zhou
PR:FIRST_NAME                    	Yiyang
PR:ADDRESS                       	Higher Education Park, Chashan Sub-district, Ouhai District, Wenzhou City
PR:EMAIL                         	zhouyiyang@wmu.edu.cn
PR:PHONE                         	13806831161
#STUDY
ST:STUDY_TITLE                   	Deep Serum Multiomics Analysis Defines the Molecular Landscape and a Diagnostic
ST:STUDY_TITLE                   	Signature of Acute Ischemic Stroke
ST:STUDY_SUMMARY                 	Acute ischemic stroke (AIS) urgently requires reliable diagnostic biomarkers to
ST:STUDY_SUMMARY                 	mitigate pre-hospital delays and enhance thrombolysis utilization. We performed
ST:STUDY_SUMMARY                 	integrated untargeted proteomic, metabolomic, and lipidomic analyses on serum
ST:STUDY_SUMMARY                 	samples from a discovery cohort (AIS patients, n=52; healthy controls [HC],
ST:STUDY_SUMMARY                 	n=50). Proteomics identified 295 differentially abundant proteins, implicating
ST:STUDY_SUMMARY                 	blood-brain barrier disruption (downregulated structural anchors: FLNA, ACTB,
ST:STUDY_SUMMARY                 	ACTN1; Rho GTPases: RAC1, CDC42), thromboinflammatory activation (upregulated
ST:STUDY_SUMMARY                 	platelet receptors: ITA2B, ITB3, GP1BA; inflammasome components: CRP, SAA) and
ST:STUDY_SUMMARY                 	complement dysregulation (C1S, C4BPA). Metabolomics and lipidomics revealed 134
ST:STUDY_SUMMARY                 	altered species, demonstrating: an energy crisis (depleted citrate cycle
ST:STUDY_SUMMARY                 	intermediates, aberrant glycolysis), oxidative stress (elevated
ST:STUDY_SUMMARY                 	glutamate/L-pyroglutamate; depleted antioxidants), and pathological lipid
ST:STUDY_SUMMARY                 	remodeling (accumulated diacylglycerols/sphingomyelins; reduced
ST:STUDY_SUMMARY                 	lysophosphatidylcholines/sterols).multiomics integration revealed that AIS
ST:STUDY_SUMMARY                 	pathogenesis involves synergistic glycolysis-triggered energy crisis,
ST:STUDY_SUMMARY                 	glutathione-dependent oxidative collapse, and catastrophic lipidome disarray.
ST:STUDY_SUMMARY                 	Machine learning (RF/LASSO) derived a diagnostic panel comprising FA9, APOC2,
ST:STUDY_SUMMARY                 	SAMP, C1S, OSTP, PCSK6, CCN2, PDGFC, HPSE, ANGL3, glutamate, glycerate, and
ST:STUDY_SUMMARY                 	succinate. This panel achieved exceptional diagnostic accuracy in an independent
ST:STUDY_SUMMARY                 	validation cohort (AIS=46, HC=48; AUC=0.998, 95% CI: 0.955-1.000), significantly
ST:STUDY_SUMMARY                 	outperforming established markers (PCSK9, succinate alone) and showing strong
ST:STUDY_SUMMARY                 	correlation with NIHSS scores. Our study establishes a mechanistically grounded,
ST:STUDY_SUMMARY                 	high-performance multiomics biomarker signature for AIS diagnosis.
ST:INSTITUTE                     	Wenzhou Medical University
ST:LAST_NAME                     	Zhou
ST:FIRST_NAME                    	Yiyang
ST:ADDRESS                       	Higher Education Park, Chashan Sub-district, Ouhai District, Wenzhou City
ST:EMAIL                         	zhouyiyang@wmu.edu.cn
ST:PHONE                         	13806831161
#SUBJECT
SU:SUBJECT_TYPE                  	Human
SU:SUBJECT_SPECIES               	Homo sapiens
SU:TAXONOMY_ID                   	9606
SU:GENDER                        	
#SUBJECT_SAMPLE_FACTORS:         	SUBJECT(optional)[tab]SAMPLE[tab]FACTORS(NAME:VALUE pairs separated by |)[tab]Raw file names and additional sample data
SUBJECT_SAMPLE_FACTORS           	N-2	N-2	Sample source:serum | Sample_type:HC | Column type:Phenomenex kinetex C18（100 × 2.1 mm，2.6 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-N2.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-N2.mzXML
SUBJECT_SAMPLE_FACTORS           	N-3	N-3	Sample source:serum | Sample_type:HC | Column type:Phenomenex kinetex C18（100 × 2.1 mm，2.6 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-N3.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-N3.mzXML
SUBJECT_SAMPLE_FACTORS           	N-4	N-4	Sample source:serum | Sample_type:HC | Column type:Phenomenex kinetex C18（100 × 2.1 mm，2.6 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-N4.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-N4.mzXML
SUBJECT_SAMPLE_FACTORS           	N-5	N-5	Sample source:serum | Sample_type:HC | Column type:Phenomenex kinetex C18（100 × 2.1 mm，2.6 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-N5.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-N5.mzXML
SUBJECT_SAMPLE_FACTORS           	N-6	N-6	Sample source:serum | Sample_type:HC | Column type:Phenomenex kinetex C18（100 × 2.1 mm，2.6 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-N6.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-N6.mzXML
SUBJECT_SAMPLE_FACTORS           	N-7	N-7	Sample source:serum | Sample_type:HC | Column type:Phenomenex kinetex C18（100 × 2.1 mm，2.6 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-N7.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-N7.mzXML
SUBJECT_SAMPLE_FACTORS           	N-8	N-8	Sample source:serum | Sample_type:HC | Column type:Phenomenex kinetex C18（100 × 2.1 mm，2.6 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-N8.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-N8.mzXML
SUBJECT_SAMPLE_FACTORS           	N-9	N-9	Sample source:serum | Sample_type:HC | Column type:Phenomenex kinetex C18（100 × 2.1 mm，2.6 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-N9.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-N9.mzXML
SUBJECT_SAMPLE_FACTORS           	N-10	N-10	Sample source:serum | Sample_type:HC | Column type:Phenomenex kinetex C18（100 × 2.1 mm，2.6 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-N10.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-N10.mzXML
SUBJECT_SAMPLE_FACTORS           	N-11	N-11	Sample source:serum | Sample_type:HC | Column type:Phenomenex kinetex C18（100 × 2.1 mm，2.6 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-N11.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-N11.mzXML
SUBJECT_SAMPLE_FACTORS           	N-12	N-12	Sample source:serum | Sample_type:HC | Column type:Phenomenex kinetex C18（100 × 2.1 mm，2.6 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-N12.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-N12.mzXML
SUBJECT_SAMPLE_FACTORS           	N-13	N-13	Sample source:serum | Sample_type:HC | Column type:Phenomenex kinetex C18（100 × 2.1 mm，2.6 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-N13.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-N13.mzXML
SUBJECT_SAMPLE_FACTORS           	N-14	N-14	Sample source:serum | Sample_type:HC | Column type:Phenomenex kinetex C18（100 × 2.1 mm，2.6 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-N14.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-N14.mzXML
SUBJECT_SAMPLE_FACTORS           	N-15	N-15	Sample source:serum | Sample_type:HC | Column type:Phenomenex kinetex C18（100 × 2.1 mm，2.6 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-N15.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-N15.mzXML
SUBJECT_SAMPLE_FACTORS           	N-16	N-16	Sample source:serum | Sample_type:HC | Column type:Phenomenex kinetex C18（100 × 2.1 mm，2.6 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-N16.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-N16.mzXML
SUBJECT_SAMPLE_FACTORS           	N-17	N-17	Sample source:serum | Sample_type:HC | Column type:Phenomenex kinetex C18（100 × 2.1 mm，2.6 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-N17.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-N17.mzXML
SUBJECT_SAMPLE_FACTORS           	N-18	N-18	Sample source:serum | Sample_type:HC | Column type:Phenomenex kinetex C18（100 × 2.1 mm，2.6 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-N18.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-N18.mzXML
SUBJECT_SAMPLE_FACTORS           	N-19	N-19	Sample source:serum | Sample_type:HC | Column type:Phenomenex kinetex C18（100 × 2.1 mm，2.6 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-N19.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-N19.mzXML
SUBJECT_SAMPLE_FACTORS           	N-20	N-20	Sample source:serum | Sample_type:HC | Column type:Phenomenex kinetex C18（100 × 2.1 mm，2.6 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-N20.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-N20.mzXML
SUBJECT_SAMPLE_FACTORS           	N-21	N-21	Sample source:serum | Sample_type:HC | Column type:Phenomenex kinetex C18（100 × 2.1 mm，2.6 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-N21.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-N21.mzXML
SUBJECT_SAMPLE_FACTORS           	N-22	N-22	Sample source:serum | Sample_type:HC | Column type:Phenomenex kinetex C18（100 × 2.1 mm，2.6 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-N22.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-N22.mzXML
SUBJECT_SAMPLE_FACTORS           	N-23	N-23	Sample source:serum | Sample_type:HC | Column type:Phenomenex kinetex C18（100 × 2.1 mm，2.6 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-N23.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-N23.mzXML
SUBJECT_SAMPLE_FACTORS           	N-24	N-24	Sample source:serum | Sample_type:HC | Column type:Phenomenex kinetex C18（100 × 2.1 mm，2.6 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-N24.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-N24.mzXML
SUBJECT_SAMPLE_FACTORS           	N-25	N-25	Sample source:serum | Sample_type:HC | Column type:Phenomenex kinetex C18（100 × 2.1 mm，2.6 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-N25.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-N25.mzXML
SUBJECT_SAMPLE_FACTORS           	N-26	N-26	Sample source:serum | Sample_type:HC | Column type:Phenomenex kinetex C18（100 × 2.1 mm，2.6 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-N26.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-N26.mzXML
SUBJECT_SAMPLE_FACTORS           	N-27	N-27	Sample source:serum | Sample_type:HC | Column type:Phenomenex kinetex C18（100 × 2.1 mm，2.6 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-N27.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-N27.mzXML
SUBJECT_SAMPLE_FACTORS           	N-28	N-28	Sample source:serum | Sample_type:HC | Column type:Phenomenex kinetex C18（100 × 2.1 mm，2.6 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-N28.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-N28.mzXML
SUBJECT_SAMPLE_FACTORS           	N-29	N-29	Sample source:serum | Sample_type:HC | Column type:Phenomenex kinetex C18（100 × 2.1 mm，2.6 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-N29.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-N29.mzXML
SUBJECT_SAMPLE_FACTORS           	N-31	N-31	Sample source:serum | Sample_type:HC | Column type:Phenomenex kinetex C18（100 × 2.1 mm，2.6 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-N31.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-N31.mzXML
SUBJECT_SAMPLE_FACTORS           	N-32	N-32	Sample source:serum | Sample_type:HC | Column type:Phenomenex kinetex C18（100 × 2.1 mm，2.6 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-N32.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-N32.mzXML
SUBJECT_SAMPLE_FACTORS           	N-33	N-33	Sample source:serum | Sample_type:HC | Column type:Phenomenex kinetex C18（100 × 2.1 mm，2.6 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-N33.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-N33.mzXML
SUBJECT_SAMPLE_FACTORS           	N-34	N-34	Sample source:serum | Sample_type:HC | Column type:Phenomenex kinetex C18（100 × 2.1 mm，2.6 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-N34.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-N34.mzXML
SUBJECT_SAMPLE_FACTORS           	N-35	N-35	Sample source:serum | Sample_type:HC | Column type:Phenomenex kinetex C18（100 × 2.1 mm，2.6 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-N35.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-N35.mzXML
SUBJECT_SAMPLE_FACTORS           	N-36	N-36	Sample source:serum | Sample_type:HC | Column type:Phenomenex kinetex C18（100 × 2.1 mm，2.6 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-N36.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-N36.mzXML
SUBJECT_SAMPLE_FACTORS           	N-37	N-37	Sample source:serum | Sample_type:HC | Column type:Phenomenex kinetex C18（100 × 2.1 mm，2.6 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-N37.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-N37.mzXML
SUBJECT_SAMPLE_FACTORS           	N-38	N-38	Sample source:serum | Sample_type:HC | Column type:Phenomenex kinetex C18（100 × 2.1 mm，2.6 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-N38.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-N38.mzXML
SUBJECT_SAMPLE_FACTORS           	N-39	N-39	Sample source:serum | Sample_type:HC | Column type:Phenomenex kinetex C18（100 × 2.1 mm，2.6 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-N39.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-N39.mzXML
SUBJECT_SAMPLE_FACTORS           	N-40	N-40	Sample source:serum | Sample_type:HC | Column type:Phenomenex kinetex C18（100 × 2.1 mm，2.6 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-N40.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-N40.mzXML
SUBJECT_SAMPLE_FACTORS           	N-41	N-41	Sample source:serum | Sample_type:HC | Column type:Phenomenex kinetex C18（100 × 2.1 mm，2.6 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-N41.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-N41.mzXML
SUBJECT_SAMPLE_FACTORS           	N-42	N-42	Sample source:serum | Sample_type:HC | Column type:Phenomenex kinetex C18（100 × 2.1 mm，2.6 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-N42.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-N42.mzXML
SUBJECT_SAMPLE_FACTORS           	N-48	N-48	Sample source:serum | Sample_type:HC | Column type:Phenomenex kinetex C18（100 × 2.1 mm，2.6 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-N48.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-N48.mzXML
SUBJECT_SAMPLE_FACTORS           	N-49	N-49	Sample source:serum | Sample_type:HC | Column type:Phenomenex kinetex C18（100 × 2.1 mm，2.6 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-N49.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-N49.mzXML
SUBJECT_SAMPLE_FACTORS           	N-52	N-52	Sample source:serum | Sample_type:HC | Column type:Phenomenex kinetex C18（100 × 2.1 mm，2.6 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-N52.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-N52.mzXML
SUBJECT_SAMPLE_FACTORS           	N-55	N-55	Sample source:serum | Sample_type:HC | Column type:Phenomenex kinetex C18（100 × 2.1 mm，2.6 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-N55.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-N55.mzXML
SUBJECT_SAMPLE_FACTORS           	N-59	N-59	Sample source:serum | Sample_type:HC | Column type:Phenomenex kinetex C18（100 × 2.1 mm，2.6 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-N59.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-N59.mzXML
SUBJECT_SAMPLE_FACTORS           	N-60	N-60	Sample source:serum | Sample_type:HC | Column type:Phenomenex kinetex C18（100 × 2.1 mm，2.6 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-N60.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-N60.mzXML
SUBJECT_SAMPLE_FACTORS           	N-62	N-62	Sample source:serum | Sample_type:HC | Column type:Phenomenex kinetex C18（100 × 2.1 mm，2.6 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-N62.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-N62.mzXML
SUBJECT_SAMPLE_FACTORS           	N-65	N-65	Sample source:serum | Sample_type:HC | Column type:Phenomenex kinetex C18（100 × 2.1 mm，2.6 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-N65.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-N65.mzXML
SUBJECT_SAMPLE_FACTORS           	N-69	N-69	Sample source:serum | Sample_type:HC | Column type:Phenomenex kinetex C18（100 × 2.1 mm，2.6 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-N69.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-N69.mzXML
SUBJECT_SAMPLE_FACTORS           	N-70	N-70	Sample source:serum | Sample_type:HC | Column type:Phenomenex kinetex C18（100 × 2.1 mm，2.6 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-N70.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-N70.mzXML
SUBJECT_SAMPLE_FACTORS           	N-71	N-71	Sample source:serum | Sample_type:HC | Column type:Phenomenex kinetex C18（100 × 2.1 mm，2.6 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-N71.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-N71.mzXML
SUBJECT_SAMPLE_FACTORS           	N-72	N-72	Sample source:serum | Sample_type:HC | Column type:Phenomenex kinetex C18（100 × 2.1 mm，2.6 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-N72.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-N72.mzXML
SUBJECT_SAMPLE_FACTORS           	N-73	N-73	Sample source:serum | Sample_type:HC | Column type:Phenomenex kinetex C18（100 × 2.1 mm，2.6 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-N73.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-N73.mzXML
SUBJECT_SAMPLE_FACTORS           	N-74	N-74	Sample source:serum | Sample_type:HC | Column type:Phenomenex kinetex C18（100 × 2.1 mm，2.6 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-N74.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-N74.mzXML
SUBJECT_SAMPLE_FACTORS           	N-75	N-75	Sample source:serum | Sample_type:HC | Column type:Phenomenex kinetex C18（100 × 2.1 mm，2.6 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-N75.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-N75.mzXML
SUBJECT_SAMPLE_FACTORS           	N-76	N-76	Sample source:serum | Sample_type:HC | Column type:Phenomenex kinetex C18（100 × 2.1 mm，2.6 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-N76.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-N76.mzXML
SUBJECT_SAMPLE_FACTORS           	N-77	N-77	Sample source:serum | Sample_type:HC | Column type:Phenomenex kinetex C18（100 × 2.1 mm，2.6 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-N77.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-N77.mzXML
SUBJECT_SAMPLE_FACTORS           	N-78	N-78	Sample source:serum | Sample_type:HC | Column type:Phenomenex kinetex C18（100 × 2.1 mm，2.6 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-N78.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-N78.mzXML
SUBJECT_SAMPLE_FACTORS           	N-79	N-79	Sample source:serum | Sample_type:HC | Column type:Phenomenex kinetex C18（100 × 2.1 mm，2.6 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-N79.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-N79.mzXML
SUBJECT_SAMPLE_FACTORS           	N-80	N-80	Sample source:serum | Sample_type:HC | Column type:Phenomenex kinetex C18（100 × 2.1 mm，2.6 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-N80.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-N80.mzXML
SUBJECT_SAMPLE_FACTORS           	N-81	N-81	Sample source:serum | Sample_type:HC | Column type:Phenomenex kinetex C18（100 × 2.1 mm，2.6 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-N81.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-N81.mzXML
SUBJECT_SAMPLE_FACTORS           	N-82	N-82	Sample source:serum | Sample_type:HC | Column type:Phenomenex kinetex C18（100 × 2.1 mm，2.6 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-N82.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-N82.mzXML
SUBJECT_SAMPLE_FACTORS           	N-83	N-83	Sample source:serum | Sample_type:HC | Column type:Phenomenex kinetex C18（100 × 2.1 mm，2.6 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-N83.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-N83.mzXML
SUBJECT_SAMPLE_FACTORS           	N-84	N-84	Sample source:serum | Sample_type:HC | Column type:Phenomenex kinetex C18（100 × 2.1 mm，2.6 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-N84.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-N84.mzXML
SUBJECT_SAMPLE_FACTORS           	N-85	N-85	Sample source:serum | Sample_type:HC | Column type:Phenomenex kinetex C18（100 × 2.1 mm，2.6 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-N85.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-N85.mzXML
SUBJECT_SAMPLE_FACTORS           	N-86	N-86	Sample source:serum | Sample_type:HC | Column type:Phenomenex kinetex C18（100 × 2.1 mm，2.6 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-N86.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-N86.mzXML
SUBJECT_SAMPLE_FACTORS           	N-87	N-87	Sample source:serum | Sample_type:HC | Column type:Phenomenex kinetex C18（100 × 2.1 mm，2.6 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-N87.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-N87.mzXML
SUBJECT_SAMPLE_FACTORS           	N-88	N-88	Sample source:serum | Sample_type:HC | Column type:Phenomenex kinetex C18（100 × 2.1 mm，2.6 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-N88.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-N88.mzXML
SUBJECT_SAMPLE_FACTORS           	N-89	N-89	Sample source:serum | Sample_type:HC | Column type:Phenomenex kinetex C18（100 × 2.1 mm，2.6 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-N89.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-N89.mzXML
SUBJECT_SAMPLE_FACTORS           	N-90	N-90	Sample source:serum | Sample_type:HC | Column type:Phenomenex kinetex C18（100 × 2.1 mm，2.6 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-N90.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-N90.mzXML
SUBJECT_SAMPLE_FACTORS           	N-91	N-91	Sample source:serum | Sample_type:HC | Column type:Phenomenex kinetex C18（100 × 2.1 mm，2.6 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-N91.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-N91.mzXML
SUBJECT_SAMPLE_FACTORS           	N-92	N-92	Sample source:serum | Sample_type:HC | Column type:Phenomenex kinetex C18（100 × 2.1 mm，2.6 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-N92.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-N92.mzXML
SUBJECT_SAMPLE_FACTORS           	N-93	N-93	Sample source:serum | Sample_type:HC | Column type:Phenomenex kinetex C18（100 × 2.1 mm，2.6 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-N93.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-N93.mzXML
SUBJECT_SAMPLE_FACTORS           	N-94	N-94	Sample source:serum | Sample_type:HC | Column type:Phenomenex kinetex C18（100 × 2.1 mm，2.6 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-N94.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-N94.mzXML
SUBJECT_SAMPLE_FACTORS           	N-95	N-95	Sample source:serum | Sample_type:HC | Column type:Phenomenex kinetex C18（100 × 2.1 mm，2.6 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-N95.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-N95.mzXML
SUBJECT_SAMPLE_FACTORS           	N-96	N-96	Sample source:serum | Sample_type:HC | Column type:Phenomenex kinetex C18（100 × 2.1 mm，2.6 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-N96.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-N96.mzXML
SUBJECT_SAMPLE_FACTORS           	N-97	N-97	Sample source:serum | Sample_type:HC | Column type:Phenomenex kinetex C18（100 × 2.1 mm，2.6 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-N97.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-N97.mzXML
SUBJECT_SAMPLE_FACTORS           	N-98	N-98	Sample source:serum | Sample_type:HC | Column type:Phenomenex kinetex C18（100 × 2.1 mm，2.6 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-N98.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-N98.mzXML
SUBJECT_SAMPLE_FACTORS           	N-99	N-99	Sample source:serum | Sample_type:HC | Column type:Phenomenex kinetex C18（100 × 2.1 mm，2.6 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-N99.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-N99.mzXML
SUBJECT_SAMPLE_FACTORS           	N-100	N-100	Sample source:serum | Sample_type:HC | Column type:Phenomenex kinetex C18（100 × 2.1 mm，2.6 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-N100.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-N100.mzXML
SUBJECT_SAMPLE_FACTORS           	N-101	N-101	Sample source:serum | Sample_type:HC | Column type:Phenomenex kinetex C18（100 × 2.1 mm，2.6 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-N101.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-N101.mzXML
SUBJECT_SAMPLE_FACTORS           	N-102	N-102	Sample source:serum | Sample_type:HC | Column type:Phenomenex kinetex C18（100 × 2.1 mm，2.6 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-N102.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-N102.mzXML
SUBJECT_SAMPLE_FACTORS           	N-103	N-103	Sample source:serum | Sample_type:HC | Column type:Phenomenex kinetex C18（100 × 2.1 mm，2.6 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-N103.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-N103.mzXML
SUBJECT_SAMPLE_FACTORS           	N-104	N-104	Sample source:serum | Sample_type:HC | Column type:Phenomenex kinetex C18（100 × 2.1 mm，2.6 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-N104.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-N104.mzXML
SUBJECT_SAMPLE_FACTORS           	N-105	N-105	Sample source:serum | Sample_type:HC | Column type:Phenomenex kinetex C18（100 × 2.1 mm，2.6 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-N105.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-N105.mzXML
SUBJECT_SAMPLE_FACTORS           	N-106	N-106	Sample source:serum | Sample_type:HC | Column type:Phenomenex kinetex C18（100 × 2.1 mm，2.6 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-N106.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-N106.mzXML
SUBJECT_SAMPLE_FACTORS           	N-107	N-107	Sample source:serum | Sample_type:HC | Column type:Phenomenex kinetex C18（100 × 2.1 mm，2.6 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-N107.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-N107.mzXML
SUBJECT_SAMPLE_FACTORS           	N-108	N-108	Sample source:serum | Sample_type:HC | Column type:Phenomenex kinetex C18（100 × 2.1 mm，2.6 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-N108.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-N108.mzXML
SUBJECT_SAMPLE_FACTORS           	N-109	N-109	Sample source:serum | Sample_type:HC | Column type:Phenomenex kinetex C18（100 × 2.1 mm，2.6 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-N109.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-N109.mzXML
SUBJECT_SAMPLE_FACTORS           	N-110	N-110	Sample source:serum | Sample_type:HC | Column type:Phenomenex kinetex C18（100 × 2.1 mm，2.6 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-N110.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-N110.mzXML
SUBJECT_SAMPLE_FACTORS           	N-111	N-111	Sample source:serum | Sample_type:HC | Column type:Phenomenex kinetex C18（100 × 2.1 mm，2.6 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-N111.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-N111.mzXML
SUBJECT_SAMPLE_FACTORS           	N-112	N-112	Sample source:serum | Sample_type:HC | Column type:Phenomenex kinetex C18（100 × 2.1 mm，2.6 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-N112.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-N112.mzXML
SUBJECT_SAMPLE_FACTORS           	N-113	N-113	Sample source:serum | Sample_type:HC | Column type:Phenomenex kinetex C18（100 × 2.1 mm，2.6 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-N113.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-N113.mzXML
SUBJECT_SAMPLE_FACTORS           	N-114	N-114	Sample source:serum | Sample_type:HC | Column type:Phenomenex kinetex C18（100 × 2.1 mm，2.6 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-N114.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-N114.mzXML
SUBJECT_SAMPLE_FACTORS           	N-115	N-115	Sample source:serum | Sample_type:HC | Column type:Phenomenex kinetex C18（100 × 2.1 mm，2.6 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-N115.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-N115.mzXML
SUBJECT_SAMPLE_FACTORS           	N-116	N-116	Sample source:serum | Sample_type:HC | Column type:Phenomenex kinetex C18（100 × 2.1 mm，2.6 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-N116.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-N116.mzXML
SUBJECT_SAMPLE_FACTORS           	N-117	N-117	Sample source:serum | Sample_type:HC | Column type:Phenomenex kinetex C18（100 × 2.1 mm，2.6 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-N117.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-N117.mzXML
SUBJECT_SAMPLE_FACTORS           	N-118	N-118	Sample source:serum | Sample_type:HC | Column type:Phenomenex kinetex C18（100 × 2.1 mm，2.6 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-N118.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-N118.mzXML
SUBJECT_SAMPLE_FACTORS           	M-1	M-1	Sample source:serum | Sample_type:AIS | Column type:Phenomenex kinetex C18（100 × 2.1 mm，2.6 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-M1.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-1.mzXML
SUBJECT_SAMPLE_FACTORS           	M-2	M-2	Sample source:serum | Sample_type:AIS | Column type:Phenomenex kinetex C18（100 × 2.1 mm，2.6 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-M2.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-2.mzXML
SUBJECT_SAMPLE_FACTORS           	M-3	M-3	Sample source:serum | Sample_type:AIS | Column type:Phenomenex kinetex C18（100 × 2.1 mm，2.6 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-M3.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-3.mzXML
SUBJECT_SAMPLE_FACTORS           	M-4	M-4	Sample source:serum | Sample_type:AIS | Column type:Phenomenex kinetex C18（100 × 2.1 mm，2.6 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-M4.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-4.mzXML
SUBJECT_SAMPLE_FACTORS           	M-5	M-5	Sample source:serum | Sample_type:AIS | Column type:Phenomenex kinetex C18（100 × 2.1 mm，2.6 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-M5.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-5.mzXML
SUBJECT_SAMPLE_FACTORS           	M-8	M-8	Sample source:serum | Sample_type:AIS | Column type:Phenomenex kinetex C18（100 × 2.1 mm，2.6 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-M8.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-8.mzXML
SUBJECT_SAMPLE_FACTORS           	M-9	M-9	Sample source:serum | Sample_type:AIS | Column type:Phenomenex kinetex C18（100 × 2.1 mm，2.6 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-M9.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-9.mzXML
SUBJECT_SAMPLE_FACTORS           	M-10	M-10	Sample source:serum | Sample_type:AIS | Column type:Phenomenex kinetex C18（100 × 2.1 mm，2.6 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-M10.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-10.mzXML
SUBJECT_SAMPLE_FACTORS           	M-11	M-11	Sample source:serum | Sample_type:AIS | Column type:Phenomenex kinetex C18（100 × 2.1 mm，2.6 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-M11.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-11.mzXML
SUBJECT_SAMPLE_FACTORS           	M-12	M-12	Sample source:serum | Sample_type:AIS | Column type:Phenomenex kinetex C18（100 × 2.1 mm，2.6 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-M12.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-12.mzXML
SUBJECT_SAMPLE_FACTORS           	M-15	M-15	Sample source:serum | Sample_type:AIS | Column type:Phenomenex kinetex C18（100 × 2.1 mm，2.6 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-M15.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-15.mzXML
SUBJECT_SAMPLE_FACTORS           	M-16	M-16	Sample source:serum | Sample_type:AIS | Column type:Phenomenex kinetex C18（100 × 2.1 mm，2.6 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-M16.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-16.mzXML
SUBJECT_SAMPLE_FACTORS           	M-17	M-17	Sample source:serum | Sample_type:AIS | Column type:Phenomenex kinetex C18（100 × 2.1 mm，2.6 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-M17.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-17.mzXML
SUBJECT_SAMPLE_FACTORS           	M-18	M-18	Sample source:serum | Sample_type:AIS | Column type:Phenomenex kinetex C18（100 × 2.1 mm，2.6 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-M18.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-18.mzXML
SUBJECT_SAMPLE_FACTORS           	M-20	M-20	Sample source:serum | Sample_type:AIS | Column type:Phenomenex kinetex C18（100 × 2.1 mm，2.6 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-M20.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-20.mzXML
SUBJECT_SAMPLE_FACTORS           	M-21	M-21	Sample source:serum | Sample_type:AIS | Column type:Phenomenex kinetex C18（100 × 2.1 mm，2.6 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-M21.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-21.mzXML
SUBJECT_SAMPLE_FACTORS           	M-22	M-22	Sample source:serum | Sample_type:AIS | Column type:Phenomenex kinetex C18（100 × 2.1 mm，2.6 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-M22.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-22.mzXML
SUBJECT_SAMPLE_FACTORS           	M-24	M-24	Sample source:serum | Sample_type:AIS | Column type:Phenomenex kinetex C18（100 × 2.1 mm，2.6 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-M24.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-24.mzXML
SUBJECT_SAMPLE_FACTORS           	M-26	M-26	Sample source:serum | Sample_type:AIS | Column type:Phenomenex kinetex C18（100 × 2.1 mm，2.6 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-M26.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-26.mzXML
SUBJECT_SAMPLE_FACTORS           	M-28	M-28	Sample source:serum | Sample_type:AIS | Column type:Phenomenex kinetex C18（100 × 2.1 mm，2.6 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-M28.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-28.mzXML
SUBJECT_SAMPLE_FACTORS           	M-29	M-29	Sample source:serum | Sample_type:AIS | Column type:Phenomenex kinetex C18（100 × 2.1 mm，2.6 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-M29.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-29.mzXML
SUBJECT_SAMPLE_FACTORS           	M-30	M-30	Sample source:serum | Sample_type:AIS | Column type:Phenomenex kinetex C18（100 × 2.1 mm，2.6 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-M30.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-30.mzXML
SUBJECT_SAMPLE_FACTORS           	M-31	M-31	Sample source:serum | Sample_type:AIS | Column type:Phenomenex kinetex C18（100 × 2.1 mm，2.6 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-M31.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-31.mzXML
SUBJECT_SAMPLE_FACTORS           	M-32	M-32	Sample source:serum | Sample_type:AIS | Column type:Phenomenex kinetex C18（100 × 2.1 mm，2.6 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-M32.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-32.mzXML
SUBJECT_SAMPLE_FACTORS           	M-33	M-33	Sample source:serum | Sample_type:AIS | Column type:Phenomenex kinetex C18（100 × 2.1 mm，2.6 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-M33.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-33.mzXML
SUBJECT_SAMPLE_FACTORS           	M-34	M-34	Sample source:serum | Sample_type:AIS | Column type:Phenomenex kinetex C18（100 × 2.1 mm，2.6 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-M34.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-34.mzXML
SUBJECT_SAMPLE_FACTORS           	M-35	M-35	Sample source:serum | Sample_type:AIS | Column type:Phenomenex kinetex C18（100 × 2.1 mm，2.6 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-M35.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-35.mzXML
SUBJECT_SAMPLE_FACTORS           	M-36	M-36	Sample source:serum | Sample_type:AIS | Column type:Phenomenex kinetex C18（100 × 2.1 mm，2.6 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-M36.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-36.mzXML
SUBJECT_SAMPLE_FACTORS           	M-37	M-37	Sample source:serum | Sample_type:AIS | Column type:Phenomenex kinetex C18（100 × 2.1 mm，2.6 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-M37.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-37.mzXML
SUBJECT_SAMPLE_FACTORS           	M-38	M-38	Sample source:serum | Sample_type:AIS | Column type:Phenomenex kinetex C18（100 × 2.1 mm，2.6 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-M38.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-38.mzXML
SUBJECT_SAMPLE_FACTORS           	M-39	M-39	Sample source:serum | Sample_type:AIS | Column type:Phenomenex kinetex C18（100 × 2.1 mm，2.6 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-M39.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-39.mzXML
SUBJECT_SAMPLE_FACTORS           	M-40	M-40	Sample source:serum | Sample_type:AIS | Column type:Phenomenex kinetex C18（100 × 2.1 mm，2.6 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-M40.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-40.mzXML
SUBJECT_SAMPLE_FACTORS           	M-41	M-41	Sample source:serum | Sample_type:AIS | Column type:Phenomenex kinetex C18（100 × 2.1 mm，2.6 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-M41.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-41.mzXML
SUBJECT_SAMPLE_FACTORS           	M-43	M-43	Sample source:serum | Sample_type:AIS | Column type:Phenomenex kinetex C18（100 × 2.1 mm，2.6 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-M43.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-43.mzXML
SUBJECT_SAMPLE_FACTORS           	M-44	M-44	Sample source:serum | Sample_type:AIS | Column type:Phenomenex kinetex C18（100 × 2.1 mm，2.6 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-M44.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-44.mzXML
SUBJECT_SAMPLE_FACTORS           	M-45	M-45	Sample source:serum | Sample_type:AIS | Column type:Phenomenex kinetex C18（100 × 2.1 mm，2.6 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-M45.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-45.mzXML
SUBJECT_SAMPLE_FACTORS           	M-46	M-46	Sample source:serum | Sample_type:AIS | Column type:Phenomenex kinetex C18（100 × 2.1 mm，2.6 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-M46.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-46.mzXML
SUBJECT_SAMPLE_FACTORS           	M-47	M-47	Sample source:serum | Sample_type:AIS | Column type:Phenomenex kinetex C18（100 × 2.1 mm，2.6 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-M47.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-47.mzXML
SUBJECT_SAMPLE_FACTORS           	M-51	M-51	Sample source:serum | Sample_type:AIS | Column type:Phenomenex kinetex C18（100 × 2.1 mm，2.6 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-M51.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-51.mzXML
SUBJECT_SAMPLE_FACTORS           	M-53	M-53	Sample source:serum | Sample_type:AIS | Column type:Phenomenex kinetex C18（100 × 2.1 mm，2.6 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-M53.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-53.mzXML
SUBJECT_SAMPLE_FACTORS           	M-57	M-57	Sample source:serum | Sample_type:AIS | Column type:Phenomenex kinetex C18（100 × 2.1 mm，2.6 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-M57.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-57.mzXML
SUBJECT_SAMPLE_FACTORS           	M-58	M-58	Sample source:serum | Sample_type:AIS | Column type:Phenomenex kinetex C18（100 × 2.1 mm，2.6 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-M58.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-58.mzXML
SUBJECT_SAMPLE_FACTORS           	M-59	M-59	Sample source:serum | Sample_type:AIS | Column type:Phenomenex kinetex C18（100 × 2.1 mm，2.6 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-M59.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-59.mzXML
SUBJECT_SAMPLE_FACTORS           	M-61	M-61	Sample source:serum | Sample_type:AIS | Column type:Phenomenex kinetex C18（100 × 2.1 mm，2.6 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-M61.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-61.mzXML
SUBJECT_SAMPLE_FACTORS           	M-62	M-62	Sample source:serum | Sample_type:AIS | Column type:Phenomenex kinetex C18（100 × 2.1 mm，2.6 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-M62.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-62.mzXML
SUBJECT_SAMPLE_FACTORS           	M-63	M-63	Sample source:serum | Sample_type:AIS | Column type:Phenomenex kinetex C18（100 × 2.1 mm，2.6 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-M63.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-63.mzXML
SUBJECT_SAMPLE_FACTORS           	M-64	M-64	Sample source:serum | Sample_type:AIS | Column type:Phenomenex kinetex C18（100 × 2.1 mm，2.6 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-M64.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-64.mzXML
SUBJECT_SAMPLE_FACTORS           	M-65	M-65	Sample source:serum | Sample_type:AIS | Column type:Phenomenex kinetex C18（100 × 2.1 mm，2.6 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-M65.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-65.mzXML
SUBJECT_SAMPLE_FACTORS           	M-66	M-66	Sample source:serum | Sample_type:AIS | Column type:Phenomenex kinetex C18（100 × 2.1 mm，2.6 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-M66.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-66.mzXML
SUBJECT_SAMPLE_FACTORS           	M-67	M-67	Sample source:serum | Sample_type:AIS | Column type:Phenomenex kinetex C18（100 × 2.1 mm，2.6 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-M67.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-67.mzXML
SUBJECT_SAMPLE_FACTORS           	M-68	M-68	Sample source:serum | Sample_type:AIS | Column type:Phenomenex kinetex C18（100 × 2.1 mm，2.6 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-M68.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-68.mzXML
SUBJECT_SAMPLE_FACTORS           	M-69	M-69	Sample source:serum | Sample_type:AIS | Column type:Phenomenex kinetex C18（100 × 2.1 mm，2.6 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-M69.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-69.mzXML
SUBJECT_SAMPLE_FACTORS           	M-70	M-70	Sample source:serum | Sample_type:AIS | Column type:Phenomenex kinetex C18（100 × 2.1 mm，2.6 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-M70.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-70.mzXML
SUBJECT_SAMPLE_FACTORS           	M-71	M-71	Sample source:serum | Sample_type:AIS | Column type:Phenomenex kinetex C18（100 × 2.1 mm，2.6 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-M71.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-71.mzXML
SUBJECT_SAMPLE_FACTORS           	M-72	M-72	Sample source:serum | Sample_type:AIS | Column type:Phenomenex kinetex C18（100 × 2.1 mm，2.6 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-M72.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-72.mzXML
SUBJECT_SAMPLE_FACTORS           	M-73	M-73	Sample source:serum | Sample_type:AIS | Column type:Phenomenex kinetex C18（100 × 2.1 mm，2.6 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-M73.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-73.mzXML
SUBJECT_SAMPLE_FACTORS           	M-74	M-74	Sample source:serum | Sample_type:AIS | Column type:Phenomenex kinetex C18（100 × 2.1 mm，2.6 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-M74.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-74.mzXML
SUBJECT_SAMPLE_FACTORS           	M-77	M-77	Sample source:serum | Sample_type:AIS | Column type:Phenomenex kinetex C18（100 × 2.1 mm，2.6 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-M77.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-77.mzXML
SUBJECT_SAMPLE_FACTORS           	M-78	M-78	Sample source:serum | Sample_type:AIS | Column type:Phenomenex kinetex C18（100 × 2.1 mm，2.6 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-M78.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-78.mzXML
SUBJECT_SAMPLE_FACTORS           	M-80	M-80	Sample source:serum | Sample_type:AIS | Column type:Phenomenex kinetex C18（100 × 2.1 mm，2.6 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-M80.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-80.mzXML
SUBJECT_SAMPLE_FACTORS           	M-81	M-81	Sample source:serum | Sample_type:AIS | Column type:Phenomenex kinetex C18（100 × 2.1 mm，2.6 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-M81.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-81.mzXML
SUBJECT_SAMPLE_FACTORS           	M-83	M-83	Sample source:serum | Sample_type:AIS | Column type:Phenomenex kinetex C18（100 × 2.1 mm，2.6 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-M83.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-83.mzXML
SUBJECT_SAMPLE_FACTORS           	M-84	M-84	Sample source:serum | Sample_type:AIS | Column type:Phenomenex kinetex C18（100 × 2.1 mm，2.6 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-M84.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-84.mzXML
SUBJECT_SAMPLE_FACTORS           	M-85	M-85	Sample source:serum | Sample_type:AIS | Column type:Phenomenex kinetex C18（100 × 2.1 mm，2.6 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-M85.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-85.mzXML
SUBJECT_SAMPLE_FACTORS           	M-86	M-86	Sample source:serum | Sample_type:AIS | Column type:Phenomenex kinetex C18（100 × 2.1 mm，2.6 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-M86.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-86.mzXML
SUBJECT_SAMPLE_FACTORS           	M-87	M-87	Sample source:serum | Sample_type:AIS | Column type:Phenomenex kinetex C18（100 × 2.1 mm，2.6 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-M87.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-87.mzXML
SUBJECT_SAMPLE_FACTORS           	M-88	M-88	Sample source:serum | Sample_type:AIS | Column type:Phenomenex kinetex C18（100 × 2.1 mm，2.6 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-M88.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-88.mzXML
SUBJECT_SAMPLE_FACTORS           	M-89	M-89	Sample source:serum | Sample_type:AIS | Column type:Phenomenex kinetex C18（100 × 2.1 mm，2.6 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-M89.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-89.mzXML
SUBJECT_SAMPLE_FACTORS           	M-91	M-91	Sample source:serum | Sample_type:AIS | Column type:Phenomenex kinetex C18（100 × 2.1 mm，2.6 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-M91.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-91.mzXML
SUBJECT_SAMPLE_FACTORS           	M-93	M-93	Sample source:serum | Sample_type:AIS | Column type:Phenomenex kinetex C18（100 × 2.1 mm，2.6 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-M93.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-93.mzXML
SUBJECT_SAMPLE_FACTORS           	M-94	M-94	Sample source:serum | Sample_type:AIS | Column type:Phenomenex kinetex C18（100 × 2.1 mm，2.6 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-M94.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-94.mzXML
SUBJECT_SAMPLE_FACTORS           	M-96	M-96	Sample source:serum | Sample_type:AIS | Column type:Phenomenex kinetex C18（100 × 2.1 mm，2.6 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-M96.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-96.mzXML
SUBJECT_SAMPLE_FACTORS           	M-98	M-98	Sample source:serum | Sample_type:AIS | Column type:Phenomenex kinetex C18（100 × 2.1 mm，2.6 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-M98.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-98.mzXML
SUBJECT_SAMPLE_FACTORS           	M-101	M-101	Sample source:serum | Sample_type:AIS | Column type:Phenomenex kinetex C18（100 × 2.1 mm，2.6 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-M101.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-101.mzXML
SUBJECT_SAMPLE_FACTORS           	M-103	M-103	Sample source:serum | Sample_type:AIS | Column type:Phenomenex kinetex C18（100 × 2.1 mm，2.6 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-M103.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-103.mzXML
SUBJECT_SAMPLE_FACTORS           	M-104	M-104	Sample source:serum | Sample_type:AIS | Column type:Phenomenex kinetex C18（100 × 2.1 mm，2.6 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-M104.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-104.mzXML
SUBJECT_SAMPLE_FACTORS           	M-106	M-106	Sample source:serum | Sample_type:AIS | Column type:Phenomenex kinetex C18（100 × 2.1 mm，2.6 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-M106.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-106.mzXML
SUBJECT_SAMPLE_FACTORS           	M-107	M-107	Sample source:serum | Sample_type:AIS | Column type:Phenomenex kinetex C18（100 × 2.1 mm，2.6 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-M107.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-107.mzXML
SUBJECT_SAMPLE_FACTORS           	M-108	M-108	Sample source:serum | Sample_type:AIS | Column type:Phenomenex kinetex C18（100 × 2.1 mm，2.6 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-M108.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-108.mzXML
SUBJECT_SAMPLE_FACTORS           	M-109	M-109	Sample source:serum | Sample_type:AIS | Column type:Phenomenex kinetex C18（100 × 2.1 mm，2.6 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-M109.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-109.mzXML
SUBJECT_SAMPLE_FACTORS           	M-111	M-111	Sample source:serum | Sample_type:AIS | Column type:Phenomenex kinetex C18（100 × 2.1 mm，2.6 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-M111.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-111.mzXML
SUBJECT_SAMPLE_FACTORS           	M-112	M-112	Sample source:serum | Sample_type:AIS | Column type:Phenomenex kinetex C18（100 × 2.1 mm，2.6 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-M112.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-112.mzXML
SUBJECT_SAMPLE_FACTORS           	M-113	M-113	Sample source:serum | Sample_type:AIS | Column type:Phenomenex kinetex C18（100 × 2.1 mm，2.6 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-M113.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-113.mzXML
SUBJECT_SAMPLE_FACTORS           	M-114	M-114	Sample source:serum | Sample_type:AIS | Column type:Phenomenex kinetex C18（100 × 2.1 mm，2.6 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-M114.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-114.mzXML
SUBJECT_SAMPLE_FACTORS           	M-116	M-116	Sample source:serum | Sample_type:AIS | Column type:Phenomenex kinetex C18（100 × 2.1 mm，2.6 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-M116.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-116.mzXML
SUBJECT_SAMPLE_FACTORS           	M-117	M-117	Sample source:serum | Sample_type:AIS | Column type:Phenomenex kinetex C18（100 × 2.1 mm，2.6 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-M117.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-117.mzXML
SUBJECT_SAMPLE_FACTORS           	M-118	M-118	Sample source:serum | Sample_type:AIS | Column type:Phenomenex kinetex C18（100 × 2.1 mm，2.6 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-M118.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-118.mzXML
SUBJECT_SAMPLE_FACTORS           	M-120	M-120	Sample source:serum | Sample_type:AIS | Column type:Phenomenex kinetex C18（100 × 2.1 mm，2.6 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-M120.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-120.mzXML
SUBJECT_SAMPLE_FACTORS           	M-121	M-121	Sample source:serum | Sample_type:AIS | Column type:Phenomenex kinetex C18（100 × 2.1 mm，2.6 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-M121.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-121.mzXML
SUBJECT_SAMPLE_FACTORS           	M-122	M-122	Sample source:serum | Sample_type:AIS | Column type:Phenomenex kinetex C18（100 × 2.1 mm，2.6 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-M122.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-122.mzXML
SUBJECT_SAMPLE_FACTORS           	M-123	M-123	Sample source:serum | Sample_type:AIS | Column type:Phenomenex kinetex C18（100 × 2.1 mm，2.6 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-M123.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-123.mzXML
SUBJECT_SAMPLE_FACTORS           	M-124	M-124	Sample source:serum | Sample_type:AIS | Column type:Phenomenex kinetex C18（100 × 2.1 mm，2.6 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-M124.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-124.mzXML
SUBJECT_SAMPLE_FACTORS           	M-127	M-127	Sample source:serum | Sample_type:AIS | Column type:Phenomenex kinetex C18（100 × 2.1 mm，2.6 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-M127.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-127.mzXML
SUBJECT_SAMPLE_FACTORS           	M-129	M-129	Sample source:serum | Sample_type:AIS | Column type:Phenomenex kinetex C18（100 × 2.1 mm，2.6 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-M129.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-129.mzXML
SUBJECT_SAMPLE_FACTORS           	M-130	M-130	Sample source:serum | Sample_type:AIS | Column type:Phenomenex kinetex C18（100 × 2.1 mm，2.6 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-M130.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-130.mzXML
SUBJECT_SAMPLE_FACTORS           	M-131	M-131	Sample source:serum | Sample_type:AIS | Column type:Phenomenex kinetex C18（100 × 2.1 mm，2.6 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-M131.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-131.mzXML
SUBJECT_SAMPLE_FACTORS           	M-132	M-132	Sample source:serum | Sample_type:AIS | Column type:Phenomenex kinetex C18（100 × 2.1 mm，2.6 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-M132.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-132.mzXML
SUBJECT_SAMPLE_FACTORS           	M-133	M-133	Sample source:serum | Sample_type:AIS | Column type:Phenomenex kinetex C18（100 × 2.1 mm，2.6 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-M133.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-133.mzXML
SUBJECT_SAMPLE_FACTORS           	N2	N2	Sample source:serum | Sample_type:HC | Column type:Waters ACQUITY UPLC BEH Amide（2.1 × 100 mm，1.7 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-N2.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-N2.mzXML
SUBJECT_SAMPLE_FACTORS           	N3	N3	Sample source:serum | Sample_type:HC | Column type:Waters ACQUITY UPLC BEH Amide（2.1 × 100 mm，1.7 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-N3.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-N3.mzXML
SUBJECT_SAMPLE_FACTORS           	N4	N4	Sample source:serum | Sample_type:HC | Column type:Waters ACQUITY UPLC BEH Amide（2.1 × 100 mm，1.7 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-N4.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-N4.mzXML
SUBJECT_SAMPLE_FACTORS           	N5	N5	Sample source:serum | Sample_type:HC | Column type:Waters ACQUITY UPLC BEH Amide（2.1 × 100 mm，1.7 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-N5.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-N5.mzXML
SUBJECT_SAMPLE_FACTORS           	N6	N6	Sample source:serum | Sample_type:HC | Column type:Waters ACQUITY UPLC BEH Amide（2.1 × 100 mm，1.7 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-N6.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-N6.mzXML
SUBJECT_SAMPLE_FACTORS           	N7	N7	Sample source:serum | Sample_type:HC | Column type:Waters ACQUITY UPLC BEH Amide（2.1 × 100 mm，1.7 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-N7.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-N7.mzXML
SUBJECT_SAMPLE_FACTORS           	N8	N8	Sample source:serum | Sample_type:HC | Column type:Waters ACQUITY UPLC BEH Amide（2.1 × 100 mm，1.7 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-N8.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-N8.mzXML
SUBJECT_SAMPLE_FACTORS           	N9	N9	Sample source:serum | Sample_type:HC | Column type:Waters ACQUITY UPLC BEH Amide（2.1 × 100 mm，1.7 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-N9.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-N9.mzXML
SUBJECT_SAMPLE_FACTORS           	N10	N10	Sample source:serum | Sample_type:HC | Column type:Waters ACQUITY UPLC BEH Amide（2.1 × 100 mm，1.7 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-N10.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-N10.mzXML
SUBJECT_SAMPLE_FACTORS           	N11	N11	Sample source:serum | Sample_type:HC | Column type:Waters ACQUITY UPLC BEH Amide（2.1 × 100 mm，1.7 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-N11.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-N11.mzXML
SUBJECT_SAMPLE_FACTORS           	N12	N12	Sample source:serum | Sample_type:HC | Column type:Waters ACQUITY UPLC BEH Amide（2.1 × 100 mm，1.7 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-N12.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-N12.mzXML
SUBJECT_SAMPLE_FACTORS           	N13	N13	Sample source:serum | Sample_type:HC | Column type:Waters ACQUITY UPLC BEH Amide（2.1 × 100 mm，1.7 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-N13.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-N13.mzXML
SUBJECT_SAMPLE_FACTORS           	N14	N14	Sample source:serum | Sample_type:HC | Column type:Waters ACQUITY UPLC BEH Amide（2.1 × 100 mm，1.7 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-N14.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-N14.mzXML
SUBJECT_SAMPLE_FACTORS           	N15	N15	Sample source:serum | Sample_type:HC | Column type:Waters ACQUITY UPLC BEH Amide（2.1 × 100 mm，1.7 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-N15.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-N15.mzXML
SUBJECT_SAMPLE_FACTORS           	N16	N16	Sample source:serum | Sample_type:HC | Column type:Waters ACQUITY UPLC BEH Amide（2.1 × 100 mm，1.7 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-N16.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-N16.mzXML
SUBJECT_SAMPLE_FACTORS           	N17	N17	Sample source:serum | Sample_type:HC | Column type:Waters ACQUITY UPLC BEH Amide（2.1 × 100 mm，1.7 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-N17.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-N17.mzXML
SUBJECT_SAMPLE_FACTORS           	N18	N18	Sample source:serum | Sample_type:HC | Column type:Waters ACQUITY UPLC BEH Amide（2.1 × 100 mm，1.7 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-N18.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-N18.mzXML
SUBJECT_SAMPLE_FACTORS           	N19	N19	Sample source:serum | Sample_type:HC | Column type:Waters ACQUITY UPLC BEH Amide（2.1 × 100 mm，1.7 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-N19.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-N19.mzXML
SUBJECT_SAMPLE_FACTORS           	N20	N20	Sample source:serum | Sample_type:HC | Column type:Waters ACQUITY UPLC BEH Amide（2.1 × 100 mm，1.7 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-N20.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-N20.mzXML
SUBJECT_SAMPLE_FACTORS           	N21	N21	Sample source:serum | Sample_type:HC | Column type:Waters ACQUITY UPLC BEH Amide（2.1 × 100 mm，1.7 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-N21.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-N21.mzXML
SUBJECT_SAMPLE_FACTORS           	N22	N22	Sample source:serum | Sample_type:HC | Column type:Waters ACQUITY UPLC BEH Amide（2.1 × 100 mm，1.7 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-N22.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-N22.mzXML
SUBJECT_SAMPLE_FACTORS           	N23	N23	Sample source:serum | Sample_type:HC | Column type:Waters ACQUITY UPLC BEH Amide（2.1 × 100 mm，1.7 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-N23.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-N23.mzXML
SUBJECT_SAMPLE_FACTORS           	N24	N24	Sample source:serum | Sample_type:HC | Column type:Waters ACQUITY UPLC BEH Amide（2.1 × 100 mm，1.7 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-N24.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-N24.mzXML
SUBJECT_SAMPLE_FACTORS           	N25	N25	Sample source:serum | Sample_type:HC | Column type:Waters ACQUITY UPLC BEH Amide（2.1 × 100 mm，1.7 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-N25.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-N25.mzXML
SUBJECT_SAMPLE_FACTORS           	N26	N26	Sample source:serum | Sample_type:HC | Column type:Waters ACQUITY UPLC BEH Amide（2.1 × 100 mm，1.7 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-N26.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-N26.mzXML
SUBJECT_SAMPLE_FACTORS           	N27	N27	Sample source:serum | Sample_type:HC | Column type:Waters ACQUITY UPLC BEH Amide（2.1 × 100 mm，1.7 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-N27.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-N27.mzXML
SUBJECT_SAMPLE_FACTORS           	N28	N28	Sample source:serum | Sample_type:HC | Column type:Waters ACQUITY UPLC BEH Amide（2.1 × 100 mm，1.7 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-N28.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-N28.mzXML
SUBJECT_SAMPLE_FACTORS           	N29	N29	Sample source:serum | Sample_type:HC | Column type:Waters ACQUITY UPLC BEH Amide（2.1 × 100 mm，1.7 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-N29.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-N29.mzXML
SUBJECT_SAMPLE_FACTORS           	N31	N31	Sample source:serum | Sample_type:HC | Column type:Waters ACQUITY UPLC BEH Amide（2.1 × 100 mm，1.7 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-N31.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-N31.mzXML
SUBJECT_SAMPLE_FACTORS           	N32	N32	Sample source:serum | Sample_type:HC | Column type:Waters ACQUITY UPLC BEH Amide（2.1 × 100 mm，1.7 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-N32.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-N32.mzXML
SUBJECT_SAMPLE_FACTORS           	N33	N33	Sample source:serum | Sample_type:HC | Column type:Waters ACQUITY UPLC BEH Amide（2.1 × 100 mm，1.7 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-N33.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-N33.mzXML
SUBJECT_SAMPLE_FACTORS           	N34	N34	Sample source:serum | Sample_type:HC | Column type:Waters ACQUITY UPLC BEH Amide（2.1 × 100 mm，1.7 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-N34.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-N34.mzXML
SUBJECT_SAMPLE_FACTORS           	N35	N35	Sample source:serum | Sample_type:HC | Column type:Waters ACQUITY UPLC BEH Amide（2.1 × 100 mm，1.7 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-N35.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-N35.mzXML
SUBJECT_SAMPLE_FACTORS           	N36	N36	Sample source:serum | Sample_type:HC | Column type:Waters ACQUITY UPLC BEH Amide（2.1 × 100 mm，1.7 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-N36.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-N36.mzXML
SUBJECT_SAMPLE_FACTORS           	N37	N37	Sample source:serum | Sample_type:HC | Column type:Waters ACQUITY UPLC BEH Amide（2.1 × 100 mm，1.7 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-N37.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-N37.mzXML
SUBJECT_SAMPLE_FACTORS           	N38	N38	Sample source:serum | Sample_type:HC | Column type:Waters ACQUITY UPLC BEH Amide（2.1 × 100 mm，1.7 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-N38.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-N38.mzXML
SUBJECT_SAMPLE_FACTORS           	N39	N39	Sample source:serum | Sample_type:HC | Column type:Waters ACQUITY UPLC BEH Amide（2.1 × 100 mm，1.7 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-N39.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-N39.mzXML
SUBJECT_SAMPLE_FACTORS           	N40	N40	Sample source:serum | Sample_type:HC | Column type:Waters ACQUITY UPLC BEH Amide（2.1 × 100 mm，1.7 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-N40.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-N40.mzXML
SUBJECT_SAMPLE_FACTORS           	N41	N41	Sample source:serum | Sample_type:HC | Column type:Waters ACQUITY UPLC BEH Amide（2.1 × 100 mm，1.7 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-N41.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-N41.mzXML
SUBJECT_SAMPLE_FACTORS           	N42	N42	Sample source:serum | Sample_type:HC | Column type:Waters ACQUITY UPLC BEH Amide（2.1 × 100 mm，1.7 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-N42.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-N42.mzXML
SUBJECT_SAMPLE_FACTORS           	N48	N48	Sample source:serum | Sample_type:HC | Column type:Waters ACQUITY UPLC BEH Amide（2.1 × 100 mm，1.7 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-N48.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-N48.mzXML
SUBJECT_SAMPLE_FACTORS           	N49	N49	Sample source:serum | Sample_type:HC | Column type:Waters ACQUITY UPLC BEH Amide（2.1 × 100 mm，1.7 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-N49.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-N49.mzXML
SUBJECT_SAMPLE_FACTORS           	N52	N52	Sample source:serum | Sample_type:HC | Column type:Waters ACQUITY UPLC BEH Amide（2.1 × 100 mm，1.7 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-N52.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-N52.mzXML
SUBJECT_SAMPLE_FACTORS           	N55	N55	Sample source:serum | Sample_type:HC | Column type:Waters ACQUITY UPLC BEH Amide（2.1 × 100 mm，1.7 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-N55.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-N55.mzXML
SUBJECT_SAMPLE_FACTORS           	N59	N59	Sample source:serum | Sample_type:HC | Column type:Waters ACQUITY UPLC BEH Amide（2.1 × 100 mm，1.7 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-N59.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-N59.mzXML
SUBJECT_SAMPLE_FACTORS           	N60	N60	Sample source:serum | Sample_type:HC | Column type:Waters ACQUITY UPLC BEH Amide（2.1 × 100 mm，1.7 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-N60.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-N60.mzXML
SUBJECT_SAMPLE_FACTORS           	N62	N62	Sample source:serum | Sample_type:HC | Column type:Waters ACQUITY UPLC BEH Amide（2.1 × 100 mm，1.7 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-N62.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-N62.mzXML
SUBJECT_SAMPLE_FACTORS           	N65	N65	Sample source:serum | Sample_type:HC | Column type:Waters ACQUITY UPLC BEH Amide（2.1 × 100 mm，1.7 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-N65.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-N65.mzXML
SUBJECT_SAMPLE_FACTORS           	N69	N69	Sample source:serum | Sample_type:HC | Column type:Waters ACQUITY UPLC BEH Amide（2.1 × 100 mm，1.7 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-N69.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-N69.mzXML
SUBJECT_SAMPLE_FACTORS           	N70	N70	Sample source:serum | Sample_type:HC | Column type:Waters ACQUITY UPLC BEH Amide（2.1 × 100 mm，1.7 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-N70.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-N70.mzXML
SUBJECT_SAMPLE_FACTORS           	N71	N71	Sample source:serum | Sample_type:HC | Column type:Waters ACQUITY UPLC BEH Amide（2.1 × 100 mm，1.7 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-N71.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-N71.mzXML
SUBJECT_SAMPLE_FACTORS           	N72	N72	Sample source:serum | Sample_type:HC | Column type:Waters ACQUITY UPLC BEH Amide（2.1 × 100 mm，1.7 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-N72.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-N72.mzXML
SUBJECT_SAMPLE_FACTORS           	N73	N73	Sample source:serum | Sample_type:HC | Column type:Waters ACQUITY UPLC BEH Amide（2.1 × 100 mm，1.7 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-N73.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-N73.mzXML
SUBJECT_SAMPLE_FACTORS           	N74	N74	Sample source:serum | Sample_type:HC | Column type:Waters ACQUITY UPLC BEH Amide（2.1 × 100 mm，1.7 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-N74.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-N74.mzXML
SUBJECT_SAMPLE_FACTORS           	N75	N75	Sample source:serum | Sample_type:HC | Column type:Waters ACQUITY UPLC BEH Amide（2.1 × 100 mm，1.7 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-N75.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-N75.mzXML
SUBJECT_SAMPLE_FACTORS           	N76	N76	Sample source:serum | Sample_type:HC | Column type:Waters ACQUITY UPLC BEH Amide（2.1 × 100 mm，1.7 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-N76.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-N76.mzXML
SUBJECT_SAMPLE_FACTORS           	N77	N77	Sample source:serum | Sample_type:HC | Column type:Waters ACQUITY UPLC BEH Amide（2.1 × 100 mm，1.7 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-N77.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-N77.mzXML
SUBJECT_SAMPLE_FACTORS           	N78	N78	Sample source:serum | Sample_type:HC | Column type:Waters ACQUITY UPLC BEH Amide（2.1 × 100 mm，1.7 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-N78.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-N78.mzXML
SUBJECT_SAMPLE_FACTORS           	N79	N79	Sample source:serum | Sample_type:HC | Column type:Waters ACQUITY UPLC BEH Amide（2.1 × 100 mm，1.7 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-N79.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-N79.mzXML
SUBJECT_SAMPLE_FACTORS           	N80	N80	Sample source:serum | Sample_type:HC | Column type:Waters ACQUITY UPLC BEH Amide（2.1 × 100 mm，1.7 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-N80.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-N80.mzXML
SUBJECT_SAMPLE_FACTORS           	N81	N81	Sample source:serum | Sample_type:HC | Column type:Waters ACQUITY UPLC BEH Amide（2.1 × 100 mm，1.7 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-N81.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-N81.mzXML
SUBJECT_SAMPLE_FACTORS           	N82	N82	Sample source:serum | Sample_type:HC | Column type:Waters ACQUITY UPLC BEH Amide（2.1 × 100 mm，1.7 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-N82.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-N82.mzXML
SUBJECT_SAMPLE_FACTORS           	N83	N83	Sample source:serum | Sample_type:HC | Column type:Waters ACQUITY UPLC BEH Amide（2.1 × 100 mm，1.7 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-N83.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-N83.mzXML
SUBJECT_SAMPLE_FACTORS           	N84	N84	Sample source:serum | Sample_type:HC | Column type:Waters ACQUITY UPLC BEH Amide（2.1 × 100 mm，1.7 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-N84.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-N84.mzXML
SUBJECT_SAMPLE_FACTORS           	N85	N85	Sample source:serum | Sample_type:HC | Column type:Waters ACQUITY UPLC BEH Amide（2.1 × 100 mm，1.7 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-N85.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-N85.mzXML
SUBJECT_SAMPLE_FACTORS           	N86	N86	Sample source:serum | Sample_type:HC | Column type:Waters ACQUITY UPLC BEH Amide（2.1 × 100 mm，1.7 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-N86.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-N86.mzXML
SUBJECT_SAMPLE_FACTORS           	N87	N87	Sample source:serum | Sample_type:HC | Column type:Waters ACQUITY UPLC BEH Amide（2.1 × 100 mm，1.7 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-N87.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-N87.mzXML
SUBJECT_SAMPLE_FACTORS           	N88	N88	Sample source:serum | Sample_type:HC | Column type:Waters ACQUITY UPLC BEH Amide（2.1 × 100 mm，1.7 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-N88.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-N88.mzXML
SUBJECT_SAMPLE_FACTORS           	N89	N89	Sample source:serum | Sample_type:HC | Column type:Waters ACQUITY UPLC BEH Amide（2.1 × 100 mm，1.7 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-N89.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-N89.mzXML
SUBJECT_SAMPLE_FACTORS           	N90	N90	Sample source:serum | Sample_type:HC | Column type:Waters ACQUITY UPLC BEH Amide（2.1 × 100 mm，1.7 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-N90.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-N90.mzXML
SUBJECT_SAMPLE_FACTORS           	N91	N91	Sample source:serum | Sample_type:HC | Column type:Waters ACQUITY UPLC BEH Amide（2.1 × 100 mm，1.7 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-N91.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-N91.mzXML
SUBJECT_SAMPLE_FACTORS           	N92	N92	Sample source:serum | Sample_type:HC | Column type:Waters ACQUITY UPLC BEH Amide（2.1 × 100 mm，1.7 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-N92.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-N92.mzXML
SUBJECT_SAMPLE_FACTORS           	N93	N93	Sample source:serum | Sample_type:HC | Column type:Waters ACQUITY UPLC BEH Amide（2.1 × 100 mm，1.7 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-N93.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-N93.mzXML
SUBJECT_SAMPLE_FACTORS           	N94	N94	Sample source:serum | Sample_type:HC | Column type:Waters ACQUITY UPLC BEH Amide（2.1 × 100 mm，1.7 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-N94.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-N94.mzXML
SUBJECT_SAMPLE_FACTORS           	N95	N95	Sample source:serum | Sample_type:HC | Column type:Waters ACQUITY UPLC BEH Amide（2.1 × 100 mm，1.7 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-N95.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-N95.mzXML
SUBJECT_SAMPLE_FACTORS           	N96	N96	Sample source:serum | Sample_type:HC | Column type:Waters ACQUITY UPLC BEH Amide（2.1 × 100 mm，1.7 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-N96.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-N96.mzXML
SUBJECT_SAMPLE_FACTORS           	N97	N97	Sample source:serum | Sample_type:HC | Column type:Waters ACQUITY UPLC BEH Amide（2.1 × 100 mm，1.7 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-N97.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-N97.mzXML
SUBJECT_SAMPLE_FACTORS           	N98	N98	Sample source:serum | Sample_type:HC | Column type:Waters ACQUITY UPLC BEH Amide（2.1 × 100 mm，1.7 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-N98.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-N98.mzXML
SUBJECT_SAMPLE_FACTORS           	N99	N99	Sample source:serum | Sample_type:HC | Column type:Waters ACQUITY UPLC BEH Amide（2.1 × 100 mm，1.7 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-N99.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-N99.mzXML
SUBJECT_SAMPLE_FACTORS           	N100	N100	Sample source:serum | Sample_type:HC | Column type:Waters ACQUITY UPLC BEH Amide（2.1 × 100 mm，1.7 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-N100.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-N100.mzXML
SUBJECT_SAMPLE_FACTORS           	N101	N101	Sample source:serum | Sample_type:HC | Column type:Waters ACQUITY UPLC BEH Amide（2.1 × 100 mm，1.7 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-N101.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-N101.mzXML
SUBJECT_SAMPLE_FACTORS           	N102	N102	Sample source:serum | Sample_type:HC | Column type:Waters ACQUITY UPLC BEH Amide（2.1 × 100 mm，1.7 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-N102.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-N102.mzXML
SUBJECT_SAMPLE_FACTORS           	N103	N103	Sample source:serum | Sample_type:HC | Column type:Waters ACQUITY UPLC BEH Amide（2.1 × 100 mm，1.7 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-N103.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-N103.mzXML
SUBJECT_SAMPLE_FACTORS           	N104	N104	Sample source:serum | Sample_type:HC | Column type:Waters ACQUITY UPLC BEH Amide（2.1 × 100 mm，1.7 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-N104.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-N104.mzXML
SUBJECT_SAMPLE_FACTORS           	N105	N105	Sample source:serum | Sample_type:HC | Column type:Waters ACQUITY UPLC BEH Amide（2.1 × 100 mm，1.7 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-N105.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-N105.mzXML
SUBJECT_SAMPLE_FACTORS           	N106	N106	Sample source:serum | Sample_type:HC | Column type:Waters ACQUITY UPLC BEH Amide（2.1 × 100 mm，1.7 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-N106.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-N106.mzXML
SUBJECT_SAMPLE_FACTORS           	N107	N107	Sample source:serum | Sample_type:HC | Column type:Waters ACQUITY UPLC BEH Amide（2.1 × 100 mm，1.7 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-N107.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-N107.mzXML
SUBJECT_SAMPLE_FACTORS           	N108	N108	Sample source:serum | Sample_type:HC | Column type:Waters ACQUITY UPLC BEH Amide（2.1 × 100 mm，1.7 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-N108.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-N108.mzXML
SUBJECT_SAMPLE_FACTORS           	N109	N109	Sample source:serum | Sample_type:HC | Column type:Waters ACQUITY UPLC BEH Amide（2.1 × 100 mm，1.7 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-N109.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-N109.mzXML
SUBJECT_SAMPLE_FACTORS           	N110	N110	Sample source:serum | Sample_type:HC | Column type:Waters ACQUITY UPLC BEH Amide（2.1 × 100 mm，1.7 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-N110.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-N110.mzXML
SUBJECT_SAMPLE_FACTORS           	N111	N111	Sample source:serum | Sample_type:HC | Column type:Waters ACQUITY UPLC BEH Amide（2.1 × 100 mm，1.7 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-N111.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-N111.mzXML
SUBJECT_SAMPLE_FACTORS           	N112	N112	Sample source:serum | Sample_type:HC | Column type:Waters ACQUITY UPLC BEH Amide（2.1 × 100 mm，1.7 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-N112.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-N112.mzXML
SUBJECT_SAMPLE_FACTORS           	N113	N113	Sample source:serum | Sample_type:HC | Column type:Waters ACQUITY UPLC BEH Amide（2.1 × 100 mm，1.7 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-N113.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-N113.mzXML
SUBJECT_SAMPLE_FACTORS           	N114	N114	Sample source:serum | Sample_type:HC | Column type:Waters ACQUITY UPLC BEH Amide（2.1 × 100 mm，1.7 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-N114.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-N114.mzXML
SUBJECT_SAMPLE_FACTORS           	N115	N115	Sample source:serum | Sample_type:HC | Column type:Waters ACQUITY UPLC BEH Amide（2.1 × 100 mm，1.7 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-N115.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-N115.mzXML
SUBJECT_SAMPLE_FACTORS           	N116	N116	Sample source:serum | Sample_type:HC | Column type:Waters ACQUITY UPLC BEH Amide（2.1 × 100 mm，1.7 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-N116.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-N116.mzXML
SUBJECT_SAMPLE_FACTORS           	N117	N117	Sample source:serum | Sample_type:HC | Column type:Waters ACQUITY UPLC BEH Amide（2.1 × 100 mm，1.7 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-N117.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-N117.mzXML
SUBJECT_SAMPLE_FACTORS           	N118	N118	Sample source:serum | Sample_type:HC | Column type:Waters ACQUITY UPLC BEH Amide（2.1 × 100 mm，1.7 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-N118.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-N118.mzXML
SUBJECT_SAMPLE_FACTORS           	M1	M1	Sample source:serum | Sample_type:AIS | Column type:Waters ACQUITY UPLC BEH Amide（2.1 × 100 mm，1.7 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-M1.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-M1.mzXML
SUBJECT_SAMPLE_FACTORS           	M2	M2	Sample source:serum | Sample_type:AIS | Column type:Waters ACQUITY UPLC BEH Amide（2.1 × 100 mm，1.7 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-M2.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-M2.mzXML
SUBJECT_SAMPLE_FACTORS           	M3	M3	Sample source:serum | Sample_type:AIS | Column type:Waters ACQUITY UPLC BEH Amide（2.1 × 100 mm，1.7 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-M3.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-M3.mzXML
SUBJECT_SAMPLE_FACTORS           	M4	M4	Sample source:serum | Sample_type:AIS | Column type:Waters ACQUITY UPLC BEH Amide（2.1 × 100 mm，1.7 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-M4.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-M4.mzXML
SUBJECT_SAMPLE_FACTORS           	M5	M5	Sample source:serum | Sample_type:AIS | Column type:Waters ACQUITY UPLC BEH Amide（2.1 × 100 mm，1.7 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-M5.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-M5.mzXML
SUBJECT_SAMPLE_FACTORS           	M8	M8	Sample source:serum | Sample_type:AIS | Column type:Waters ACQUITY UPLC BEH Amide（2.1 × 100 mm，1.7 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-M8.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-M8.mzXML
SUBJECT_SAMPLE_FACTORS           	M9	M9	Sample source:serum | Sample_type:AIS | Column type:Waters ACQUITY UPLC BEH Amide（2.1 × 100 mm，1.7 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-M9.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-M9.mzXML
SUBJECT_SAMPLE_FACTORS           	M10	M10	Sample source:serum | Sample_type:AIS | Column type:Waters ACQUITY UPLC BEH Amide（2.1 × 100 mm，1.7 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-M10.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-M10.mzXML
SUBJECT_SAMPLE_FACTORS           	M11	M11	Sample source:serum | Sample_type:AIS | Column type:Waters ACQUITY UPLC BEH Amide（2.1 × 100 mm，1.7 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-M11.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-M11.mzXML
SUBJECT_SAMPLE_FACTORS           	M12	M12	Sample source:serum | Sample_type:AIS | Column type:Waters ACQUITY UPLC BEH Amide（2.1 × 100 mm，1.7 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-M12.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-M12.mzXML
SUBJECT_SAMPLE_FACTORS           	M15	M15	Sample source:serum | Sample_type:AIS | Column type:Waters ACQUITY UPLC BEH Amide（2.1 × 100 mm，1.7 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-M15.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-M15.mzXML
SUBJECT_SAMPLE_FACTORS           	M16	M16	Sample source:serum | Sample_type:AIS | Column type:Waters ACQUITY UPLC BEH Amide（2.1 × 100 mm，1.7 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-M16.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-M16.mzXML
SUBJECT_SAMPLE_FACTORS           	M17	M17	Sample source:serum | Sample_type:AIS | Column type:Waters ACQUITY UPLC BEH Amide（2.1 × 100 mm，1.7 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-M17.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-M17.mzXML
SUBJECT_SAMPLE_FACTORS           	M18	M18	Sample source:serum | Sample_type:AIS | Column type:Waters ACQUITY UPLC BEH Amide（2.1 × 100 mm，1.7 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-M18.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-M18.mzXML
SUBJECT_SAMPLE_FACTORS           	M20	M20	Sample source:serum | Sample_type:AIS | Column type:Waters ACQUITY UPLC BEH Amide（2.1 × 100 mm，1.7 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-M20.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-M20.mzXML
SUBJECT_SAMPLE_FACTORS           	M21	M21	Sample source:serum | Sample_type:AIS | Column type:Waters ACQUITY UPLC BEH Amide（2.1 × 100 mm，1.7 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-M21.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-M21.mzXML
SUBJECT_SAMPLE_FACTORS           	M22	M22	Sample source:serum | Sample_type:AIS | Column type:Waters ACQUITY UPLC BEH Amide（2.1 × 100 mm，1.7 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-M22.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-M22.mzXML
SUBJECT_SAMPLE_FACTORS           	M24	M24	Sample source:serum | Sample_type:AIS | Column type:Waters ACQUITY UPLC BEH Amide（2.1 × 100 mm，1.7 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-M24.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-M24.mzXML
SUBJECT_SAMPLE_FACTORS           	M26	M26	Sample source:serum | Sample_type:AIS | Column type:Waters ACQUITY UPLC BEH Amide（2.1 × 100 mm，1.7 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-M26.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-M26.mzXML
SUBJECT_SAMPLE_FACTORS           	M28	M28	Sample source:serum | Sample_type:AIS | Column type:Waters ACQUITY UPLC BEH Amide（2.1 × 100 mm，1.7 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-M28.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-M28.mzXML
SUBJECT_SAMPLE_FACTORS           	M29	M29	Sample source:serum | Sample_type:AIS | Column type:Waters ACQUITY UPLC BEH Amide（2.1 × 100 mm，1.7 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-M29.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-M29.mzXML
SUBJECT_SAMPLE_FACTORS           	M30	M30	Sample source:serum | Sample_type:AIS | Column type:Waters ACQUITY UPLC BEH Amide（2.1 × 100 mm，1.7 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-M30.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-M30.mzXML
SUBJECT_SAMPLE_FACTORS           	M31	M31	Sample source:serum | Sample_type:AIS | Column type:Waters ACQUITY UPLC BEH Amide（2.1 × 100 mm，1.7 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-M31.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-M31.mzXML
SUBJECT_SAMPLE_FACTORS           	M32	M32	Sample source:serum | Sample_type:AIS | Column type:Waters ACQUITY UPLC BEH Amide（2.1 × 100 mm，1.7 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-M32.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-M32.mzXML
SUBJECT_SAMPLE_FACTORS           	M33	M33	Sample source:serum | Sample_type:AIS | Column type:Waters ACQUITY UPLC BEH Amide（2.1 × 100 mm，1.7 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-M33.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-M33.mzXML
SUBJECT_SAMPLE_FACTORS           	M34	M34	Sample source:serum | Sample_type:AIS | Column type:Waters ACQUITY UPLC BEH Amide（2.1 × 100 mm，1.7 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-M34.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-M34.mzXML
SUBJECT_SAMPLE_FACTORS           	M35	M35	Sample source:serum | Sample_type:AIS | Column type:Waters ACQUITY UPLC BEH Amide（2.1 × 100 mm，1.7 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-M35.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-M35.mzXML
SUBJECT_SAMPLE_FACTORS           	M36	M36	Sample source:serum | Sample_type:AIS | Column type:Waters ACQUITY UPLC BEH Amide（2.1 × 100 mm，1.7 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-M36.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-M36.mzXML
SUBJECT_SAMPLE_FACTORS           	M37	M37	Sample source:serum | Sample_type:AIS | Column type:Waters ACQUITY UPLC BEH Amide（2.1 × 100 mm，1.7 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-M37.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-M37.mzXML
SUBJECT_SAMPLE_FACTORS           	M38	M38	Sample source:serum | Sample_type:AIS | Column type:Waters ACQUITY UPLC BEH Amide（2.1 × 100 mm，1.7 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-M38.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-M38.mzXML
SUBJECT_SAMPLE_FACTORS           	M39	M39	Sample source:serum | Sample_type:AIS | Column type:Waters ACQUITY UPLC BEH Amide（2.1 × 100 mm，1.7 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-M39.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-M39.mzXML
SUBJECT_SAMPLE_FACTORS           	M40	M40	Sample source:serum | Sample_type:AIS | Column type:Waters ACQUITY UPLC BEH Amide（2.1 × 100 mm，1.7 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-M40.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-M40.mzXML
SUBJECT_SAMPLE_FACTORS           	M41	M41	Sample source:serum | Sample_type:AIS | Column type:Waters ACQUITY UPLC BEH Amide（2.1 × 100 mm，1.7 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-M41.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-M41.mzXML
SUBJECT_SAMPLE_FACTORS           	M43	M43	Sample source:serum | Sample_type:AIS | Column type:Waters ACQUITY UPLC BEH Amide（2.1 × 100 mm，1.7 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-M43.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-M43.mzXML
SUBJECT_SAMPLE_FACTORS           	M44	M44	Sample source:serum | Sample_type:AIS | Column type:Waters ACQUITY UPLC BEH Amide（2.1 × 100 mm，1.7 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-M44.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-M44.mzXML
SUBJECT_SAMPLE_FACTORS           	M45	M45	Sample source:serum | Sample_type:AIS | Column type:Waters ACQUITY UPLC BEH Amide（2.1 × 100 mm，1.7 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-M45.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-M45.mzXML
SUBJECT_SAMPLE_FACTORS           	M46	M46	Sample source:serum | Sample_type:AIS | Column type:Waters ACQUITY UPLC BEH Amide（2.1 × 100 mm，1.7 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-M46.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-M46.mzXML
SUBJECT_SAMPLE_FACTORS           	M47	M47	Sample source:serum | Sample_type:AIS | Column type:Waters ACQUITY UPLC BEH Amide（2.1 × 100 mm，1.7 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-M47.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-M47.mzXML
SUBJECT_SAMPLE_FACTORS           	M51	M51	Sample source:serum | Sample_type:AIS | Column type:Waters ACQUITY UPLC BEH Amide（2.1 × 100 mm，1.7 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-M51.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-M51.mzXML
SUBJECT_SAMPLE_FACTORS           	M53	M53	Sample source:serum | Sample_type:AIS | Column type:Waters ACQUITY UPLC BEH Amide（2.1 × 100 mm，1.7 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-M53.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-M53.mzXML
SUBJECT_SAMPLE_FACTORS           	M57	M57	Sample source:serum | Sample_type:AIS | Column type:Waters ACQUITY UPLC BEH Amide（2.1 × 100 mm，1.7 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-M57.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-M57.mzXML
SUBJECT_SAMPLE_FACTORS           	M58	M58	Sample source:serum | Sample_type:AIS | Column type:Waters ACQUITY UPLC BEH Amide（2.1 × 100 mm，1.7 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-M58.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-M58.mzXML
SUBJECT_SAMPLE_FACTORS           	M59	M59	Sample source:serum | Sample_type:AIS | Column type:Waters ACQUITY UPLC BEH Amide（2.1 × 100 mm，1.7 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-M59.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-M59.mzXML
SUBJECT_SAMPLE_FACTORS           	M61	M61	Sample source:serum | Sample_type:AIS | Column type:Waters ACQUITY UPLC BEH Amide（2.1 × 100 mm，1.7 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-M61.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-M61.mzXML
SUBJECT_SAMPLE_FACTORS           	M62	M62	Sample source:serum | Sample_type:AIS | Column type:Waters ACQUITY UPLC BEH Amide（2.1 × 100 mm，1.7 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-M62.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-M62.mzXML
SUBJECT_SAMPLE_FACTORS           	M63	M63	Sample source:serum | Sample_type:AIS | Column type:Waters ACQUITY UPLC BEH Amide（2.1 × 100 mm，1.7 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-M63.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-M63.mzXML
SUBJECT_SAMPLE_FACTORS           	M64	M64	Sample source:serum | Sample_type:AIS | Column type:Waters ACQUITY UPLC BEH Amide（2.1 × 100 mm，1.7 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-M64.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-M64.mzXML
SUBJECT_SAMPLE_FACTORS           	M65	M65	Sample source:serum | Sample_type:AIS | Column type:Waters ACQUITY UPLC BEH Amide（2.1 × 100 mm，1.7 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-M65.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-M65.mzXML
SUBJECT_SAMPLE_FACTORS           	M66	M66	Sample source:serum | Sample_type:AIS | Column type:Waters ACQUITY UPLC BEH Amide（2.1 × 100 mm，1.7 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-M66.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-M66.mzXML
SUBJECT_SAMPLE_FACTORS           	M67	M67	Sample source:serum | Sample_type:AIS | Column type:Waters ACQUITY UPLC BEH Amide（2.1 × 100 mm，1.7 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-M67.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-M67.mzXML
SUBJECT_SAMPLE_FACTORS           	M68	M68	Sample source:serum | Sample_type:AIS | Column type:Waters ACQUITY UPLC BEH Amide（2.1 × 100 mm，1.7 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-M68.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-M68.mzXML
SUBJECT_SAMPLE_FACTORS           	M69	M69	Sample source:serum | Sample_type:AIS | Column type:Waters ACQUITY UPLC BEH Amide（2.1 × 100 mm，1.7 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-M69.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-M69.mzXML
SUBJECT_SAMPLE_FACTORS           	M70	M70	Sample source:serum | Sample_type:AIS | Column type:Waters ACQUITY UPLC BEH Amide（2.1 × 100 mm，1.7 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-M70.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-M70.mzXML
SUBJECT_SAMPLE_FACTORS           	M71	M71	Sample source:serum | Sample_type:AIS | Column type:Waters ACQUITY UPLC BEH Amide（2.1 × 100 mm，1.7 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-M71.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-M71.mzXML
SUBJECT_SAMPLE_FACTORS           	M72	M72	Sample source:serum | Sample_type:AIS | Column type:Waters ACQUITY UPLC BEH Amide（2.1 × 100 mm，1.7 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-M72.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-M72.mzXML
SUBJECT_SAMPLE_FACTORS           	M73	M73	Sample source:serum | Sample_type:AIS | Column type:Waters ACQUITY UPLC BEH Amide（2.1 × 100 mm，1.7 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-M73.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-M73.mzXML
SUBJECT_SAMPLE_FACTORS           	M74	M74	Sample source:serum | Sample_type:AIS | Column type:Waters ACQUITY UPLC BEH Amide（2.1 × 100 mm，1.7 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-M74.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-M74.mzXML
SUBJECT_SAMPLE_FACTORS           	M77	M77	Sample source:serum | Sample_type:AIS | Column type:Waters ACQUITY UPLC BEH Amide（2.1 × 100 mm，1.7 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-M77.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-M77.mzXML
SUBJECT_SAMPLE_FACTORS           	M78	M78	Sample source:serum | Sample_type:AIS | Column type:Waters ACQUITY UPLC BEH Amide（2.1 × 100 mm，1.7 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-M78.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-M78.mzXML
SUBJECT_SAMPLE_FACTORS           	M80	M80	Sample source:serum | Sample_type:AIS | Column type:Waters ACQUITY UPLC BEH Amide（2.1 × 100 mm，1.7 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-M80.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-M80.mzXML
SUBJECT_SAMPLE_FACTORS           	M81	M81	Sample source:serum | Sample_type:AIS | Column type:Waters ACQUITY UPLC BEH Amide（2.1 × 100 mm，1.7 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-M81.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-M81.mzXML
SUBJECT_SAMPLE_FACTORS           	M83	M83	Sample source:serum | Sample_type:AIS | Column type:Waters ACQUITY UPLC BEH Amide（2.1 × 100 mm，1.7 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-M83.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-M83.mzXML
SUBJECT_SAMPLE_FACTORS           	M84	M84	Sample source:serum | Sample_type:AIS | Column type:Waters ACQUITY UPLC BEH Amide（2.1 × 100 mm，1.7 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-M84.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-M84.mzXML
SUBJECT_SAMPLE_FACTORS           	M85	M85	Sample source:serum | Sample_type:AIS | Column type:Waters ACQUITY UPLC BEH Amide（2.1 × 100 mm，1.7 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-M85.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-M85.mzXML
SUBJECT_SAMPLE_FACTORS           	M86	M86	Sample source:serum | Sample_type:AIS | Column type:Waters ACQUITY UPLC BEH Amide（2.1 × 100 mm，1.7 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-M86.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-M86.mzXML
SUBJECT_SAMPLE_FACTORS           	M87	M87	Sample source:serum | Sample_type:AIS | Column type:Waters ACQUITY UPLC BEH Amide（2.1 × 100 mm，1.7 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-M87.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-M87.mzXML
SUBJECT_SAMPLE_FACTORS           	M88	M88	Sample source:serum | Sample_type:AIS | Column type:Waters ACQUITY UPLC BEH Amide（2.1 × 100 mm，1.7 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-M88.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-M88.mzXML
SUBJECT_SAMPLE_FACTORS           	M89	M89	Sample source:serum | Sample_type:AIS | Column type:Waters ACQUITY UPLC BEH Amide（2.1 × 100 mm，1.7 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-M89.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-M89.mzXML
SUBJECT_SAMPLE_FACTORS           	M91	M91	Sample source:serum | Sample_type:AIS | Column type:Waters ACQUITY UPLC BEH Amide（2.1 × 100 mm，1.7 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-M91.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-M91.mzXML
SUBJECT_SAMPLE_FACTORS           	M93	M93	Sample source:serum | Sample_type:AIS | Column type:Waters ACQUITY UPLC BEH Amide（2.1 × 100 mm，1.7 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-M93.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-M93.mzXML
SUBJECT_SAMPLE_FACTORS           	M94	M94	Sample source:serum | Sample_type:AIS | Column type:Waters ACQUITY UPLC BEH Amide（2.1 × 100 mm，1.7 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-M94.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-M94.mzXML
SUBJECT_SAMPLE_FACTORS           	M96	M96	Sample source:serum | Sample_type:AIS | Column type:Waters ACQUITY UPLC BEH Amide（2.1 × 100 mm，1.7 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-M96.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-M96.mzXML
SUBJECT_SAMPLE_FACTORS           	M98	M98	Sample source:serum | Sample_type:AIS | Column type:Waters ACQUITY UPLC BEH Amide（2.1 × 100 mm，1.7 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-M98.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-M98.mzXML
SUBJECT_SAMPLE_FACTORS           	M101	M101	Sample source:serum | Sample_type:AIS | Column type:Waters ACQUITY UPLC BEH Amide（2.1 × 100 mm，1.7 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-M101.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-M101.mzXML
SUBJECT_SAMPLE_FACTORS           	M103	M103	Sample source:serum | Sample_type:AIS | Column type:Waters ACQUITY UPLC BEH Amide（2.1 × 100 mm，1.7 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-M103.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-M103.mzXML
SUBJECT_SAMPLE_FACTORS           	M104	M104	Sample source:serum | Sample_type:AIS | Column type:Waters ACQUITY UPLC BEH Amide（2.1 × 100 mm，1.7 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-M104.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-M104.mzXML
SUBJECT_SAMPLE_FACTORS           	M106	M106	Sample source:serum | Sample_type:AIS | Column type:Waters ACQUITY UPLC BEH Amide（2.1 × 100 mm，1.7 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-M106.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-M106.mzXML
SUBJECT_SAMPLE_FACTORS           	M107	M107	Sample source:serum | Sample_type:AIS | Column type:Waters ACQUITY UPLC BEH Amide（2.1 × 100 mm，1.7 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-M107.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-M107.mzXML
SUBJECT_SAMPLE_FACTORS           	M108	M108	Sample source:serum | Sample_type:AIS | Column type:Waters ACQUITY UPLC BEH Amide（2.1 × 100 mm，1.7 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-M108.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-M108.mzXML
SUBJECT_SAMPLE_FACTORS           	M109	M109	Sample source:serum | Sample_type:AIS | Column type:Waters ACQUITY UPLC BEH Amide（2.1 × 100 mm，1.7 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-M109.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-M109.mzXML
SUBJECT_SAMPLE_FACTORS           	M111	M111	Sample source:serum | Sample_type:AIS | Column type:Waters ACQUITY UPLC BEH Amide（2.1 × 100 mm，1.7 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-M111.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-M111.mzXML
SUBJECT_SAMPLE_FACTORS           	M112	M112	Sample source:serum | Sample_type:AIS | Column type:Waters ACQUITY UPLC BEH Amide（2.1 × 100 mm，1.7 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-M112.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-M112.mzXML
SUBJECT_SAMPLE_FACTORS           	M113	M113	Sample source:serum | Sample_type:AIS | Column type:Waters ACQUITY UPLC BEH Amide（2.1 × 100 mm，1.7 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-M113.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-M113.mzXML
SUBJECT_SAMPLE_FACTORS           	M114	M114	Sample source:serum | Sample_type:AIS | Column type:Waters ACQUITY UPLC BEH Amide（2.1 × 100 mm，1.7 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-M114.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-M114.mzXML
SUBJECT_SAMPLE_FACTORS           	M116	M116	Sample source:serum | Sample_type:AIS | Column type:Waters ACQUITY UPLC BEH Amide（2.1 × 100 mm，1.7 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-M116.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-M116.mzXML
SUBJECT_SAMPLE_FACTORS           	M117	M117	Sample source:serum | Sample_type:AIS | Column type:Waters ACQUITY UPLC BEH Amide（2.1 × 100 mm，1.7 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-M117.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-M117.mzXML
SUBJECT_SAMPLE_FACTORS           	M118	M118	Sample source:serum | Sample_type:AIS | Column type:Waters ACQUITY UPLC BEH Amide（2.1 × 100 mm，1.7 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-M118.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-M118.mzXML
SUBJECT_SAMPLE_FACTORS           	M120	M120	Sample source:serum | Sample_type:AIS | Column type:Waters ACQUITY UPLC BEH Amide（2.1 × 100 mm，1.7 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-M120.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-M120.mzXML
SUBJECT_SAMPLE_FACTORS           	M121	M121	Sample source:serum | Sample_type:AIS | Column type:Waters ACQUITY UPLC BEH Amide（2.1 × 100 mm，1.7 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-M121.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-M121.mzXML
SUBJECT_SAMPLE_FACTORS           	M122	M122	Sample source:serum | Sample_type:AIS | Column type:Waters ACQUITY UPLC BEH Amide（2.1 × 100 mm，1.7 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-M122.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-M122.mzXML
SUBJECT_SAMPLE_FACTORS           	M123	M123	Sample source:serum | Sample_type:AIS | Column type:Waters ACQUITY UPLC BEH Amide（2.1 × 100 mm，1.7 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-M123.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-M123.mzXML
SUBJECT_SAMPLE_FACTORS           	M124	M124	Sample source:serum | Sample_type:AIS | Column type:Waters ACQUITY UPLC BEH Amide（2.1 × 100 mm，1.7 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-M124.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-M124.mzXML
SUBJECT_SAMPLE_FACTORS           	M127	M127	Sample source:serum | Sample_type:AIS | Column type:Waters ACQUITY UPLC BEH Amide（2.1 × 100 mm，1.7 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-M127.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-M127.mzXML
SUBJECT_SAMPLE_FACTORS           	M129	M129	Sample source:serum | Sample_type:AIS | Column type:Waters ACQUITY UPLC BEH Amide（2.1 × 100 mm，1.7 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-M129.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-M129.mzXML
SUBJECT_SAMPLE_FACTORS           	M130	M130	Sample source:serum | Sample_type:AIS | Column type:Waters ACQUITY UPLC BEH Amide（2.1 × 100 mm，1.7 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-M130.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-M130.mzXML
SUBJECT_SAMPLE_FACTORS           	M131	M131	Sample source:serum | Sample_type:AIS | Column type:Waters ACQUITY UPLC BEH Amide（2.1 × 100 mm，1.7 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-M131.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-M131.mzXML
SUBJECT_SAMPLE_FACTORS           	M132	M132	Sample source:serum | Sample_type:AIS | Column type:Waters ACQUITY UPLC BEH Amide（2.1 × 100 mm，1.7 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-M132.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-M132.mzXML
SUBJECT_SAMPLE_FACTORS           	M133	M133	Sample source:serum | Sample_type:AIS | Column type:Waters ACQUITY UPLC BEH Amide（2.1 × 100 mm，1.7 μm）	RAW_FILE_NAME(Positive_mzXML_FILE_NAME)=pos-M133.mzXML; RAW_FILE_NAME(Negative_mzXML_FILE_NAME)=neg-M133.mzXML
#COLLECTION
CO:COLLECTION_SUMMARY            	Serum samples from ischemic stroke patients were collected at the Second
CO:COLLECTION_SUMMARY            	Affiliated Hospital of Wenzhou Medical University between March 2021 and August
CO:COLLECTION_SUMMARY            	2022. A total of 196 participants were enrolled in this study, including 52 AIS
CO:COLLECTION_SUMMARY            	patients and 50 age- and sex-matched healthy controls (HC) in the discovery
CO:COLLECTION_SUMMARY            	cohort, and 46 AIS patients and 48 age- and sex-matched HC in the validation
CO:COLLECTION_SUMMARY            	cohort. Patient inclusion criteria were: (1) age >18 years; (2) diagnosis of
CO:COLLECTION_SUMMARY            	AIS; (3) provision of informed consent directly by the patient or by their
CO:COLLECTION_SUMMARY            	immediate relatives. Patients were excluded if they had: (1) cerebral
CO:COLLECTION_SUMMARY            	hemorrhage; (2) severe cardiac, pulmonary, or renal impairment; (3) malignancy;
CO:COLLECTION_SUMMARY            	(4) surgery within the past 3 months; or (5) transient ischemic attack or
CO:COLLECTION_SUMMARY            	disease of unknown etiology. Blood samples were collected using
CO:COLLECTION_SUMMARY            	ethylenediaminetetraacetic acid as an anticoagulant. Samples were allowed to
CO:COLLECTION_SUMMARY            	clot at room temperature for 30 minutes and then centrifuged (3,000 × g, 10
CO:COLLECTION_SUMMARY            	min) to collect the supernatant. All patients and their families were informed
CO:COLLECTION_SUMMARY            	about the study procedures and provided written informed consent. All
CO:COLLECTION_SUMMARY            	experiments involving human samples were approved by the Ethics Committee of the
CO:COLLECTION_SUMMARY            	Second Affiliated Hospital of Wenzhou Medical University (No. 2021-K-73-02) and
CO:COLLECTION_SUMMARY            	conducted in accordance with the principles of the Declaration of Helsinki.
CO:SAMPLE_TYPE                   	Blood (serum)
#TREATMENT
TR:TREATMENT_SUMMARY             	Blood samples were collected using ethylenediaminetetraacetic acid as an
TR:TREATMENT_SUMMARY             	anticoagulant. Samples were allowed to clot at room temperature for 30 minutes
TR:TREATMENT_SUMMARY             	and then centrifuged (3,000 × g, 10 min) to collect the supernatant.
#SAMPLEPREP
SP:SAMPLEPREP_SUMMARY            	For untargeted metabolomics, 150 µL of serum was aliquoted. Proteins were
SP:SAMPLEPREP_SUMMARY            	precipitated by adding 400 µL of cold acetonitrile:methanol (1:1, v/v) to 200
SP:SAMPLEPREP_SUMMARY            	µL of plasma. After vortexing for 60 s and centrifugation, the supernatant was
SP:SAMPLEPREP_SUMMARY            	collected. Sequential liquid-liquid extraction was performed by adding methanol:
SP:SAMPLEPREP_SUMMARY            	water: dichloromethane (1:1:2, v/v/v). Samples were homogenized (60 Hz, 2 min),
SP:SAMPLEPREP_SUMMARY            	incubated at 4 ℃ for 30 min, and centrifuged (15,000 × g, 15 min, 4 ℃). The
SP:SAMPLEPREP_SUMMARY            	upper methanol-water layer (polar metabolites) and lower dichloromethane layer
SP:SAMPLEPREP_SUMMARY            	(lipids) were separately collected. Each layer was dried under N2 gas. Polar
SP:SAMPLEPREP_SUMMARY            	extracts were reconstituted in 200 µL of 50% acetonitrile in water containing
SP:SAMPLEPREP_SUMMARY            	2-chloro-L-phenylalanine (internal standard). Lipid extracts were reconstituted
SP:SAMPLEPREP_SUMMARY            	in 100 µL of chloroform:methanol (1:1, v/v) containing the internal standard.
SP:SAMPLEPREP_SUMMARY            	Samples were centrifuged (15,000 × g, 15 min, 4 ℃), and supernatants were
SP:SAMPLEPREP_SUMMARY            	transferred to LC vials with glass inserts for analysis. Quality control (QC)
SP:SAMPLEPREP_SUMMARY            	samples were prepared by pooling 10 µL aliquots from each sample extract.
#CHROMATOGRAPHY
CH:CHROMATOGRAPHY_TYPE           	Reversed phase
CH:INSTRUMENT_NAME               	Waters Acquity H-Class
CH:COLUMN_NAME                   	Phenomenex Kinetex C18 (100 x 2.1mm,2.6um)
CH:SOLVENT_A                     	H2O: MeOH: ACN (3:1:1, v/v/v) with 5 mM ammonium acetate;
CH:SOLVENT_B                     	isopropanol
CH:FLOW_GRADIENT                 	0-0.5 min, 25% B; 0.5-1.5 min, 25-40% B; 1.5-3 min, 40-60% B; 3-13 min, 60-98%
CH:FLOW_GRADIENT                 	B; 13-13.1 min, 98-25% B; 13.1-18 min, 25% B
CH:FLOW_RATE                     	0.3 mL/min
CH:COLUMN_TEMPERATURE            	40℃
#ANALYSIS
AN:ANALYSIS_TYPE                 	MS
#MS
MS:INSTRUMENT_NAME               	ABI Sciex 6600 TripleTOF
MS:INSTRUMENT_TYPE               	QTOF
MS:MS_TYPE                       	ESI
MS:ION_MODE                      	POSITIVE
MS:MS_COMMENTS                   	Raw data were processed using MarkerView software. Key parameters included: peak
MS:MS_COMMENTS                   	extraction time 0.5-15 min, retention time tolerance 0.1 min, m/z tolerance 20
MS:MS_COMMENTS                   	ppm, minimum peak intensity 500. Metabolites detected in <80% of samples were
MS:MS_COMMENTS                   	excluded. Peaks with intensity <500 were removed. Coefficients of variation (CV%
MS:MS_COMMENTS                   	= [standard deviation / mean] × 100%) were calculated across QC injections;
MS:MS_COMMENTS                   	peaks with CV% > 30% were excluded. Multivariate statistical analysis, including
MS:MS_COMMENTS                   	principal component analysis (PCA), was performed using SIMCA-P software (v14.0,
MS:MS_COMMENTS                   	Umetrics, Umeå, Sweden). Univariate statistical analysis was used to identify
MS:MS_COMMENTS                   	significant differential metabolites, visualized by volcano plots. Metabolite
MS:MS_COMMENTS                   	identification was based on accurate m/z and MS/MS fragmentation patterns using
MS:MS_COMMENTS                   	MS-DIAL, MetDNA2 , One-MAP software and validated against the Human Metabolome
MS:MS_COMMENTS                   	Database . Pathway enrichment analysis was performed using MetaboAnalyst.
MS:MS_RESULTS_FILE               	ST004198_AN006979_Results.txt	UNITS:m/z	Has m/z:Yes	Has RT:Yes	RT units:Minutes
#END