#METABOLOMICS WORKBENCH ffouladi_20250917_042822 DATATRACK_ID:6439 STUDY_ID:ST004208 ANALYSIS_ID:AN006998 PROJECT_ID:PR002653 VERSION 1 CREATED_ON 09-22-2025 #PROJECT PR:PROJECT_TITLE A taxon-specific measurement of disruption in a multi-modal study of microbiomes PR:PROJECT_TITLE and metabolomes reveals system-wide dysbiosis preceding HIV-1 infection PR:PROJECT_SUMMARY The microbiome is important in immune responses and inflammation in HIV-1 PR:PROJECT_SUMMARY infection. Hence, a deeper understanding of the microbiome prior to HIV-1 PR:PROJECT_SUMMARY infection is potentially important for HIV-1 prevention strategies. Using stool, PR:PROJECT_SUMMARY oral washes, and plasma biospecimens obtained from HIV-1 negative men who have PR:PROJECT_SUMMARY sex with men (MSM), we found several differences in microbial ecologies, gene PR:PROJECT_SUMMARY functions, and metabolites between MSM who became HIV-1 infected approximately 6 PR:PROJECT_SUMMARY months later and those who remained HIV-1 uninfected. The HIV-1 infected MSM had PR:PROJECT_SUMMARY an enrichment of enzymes involved in purine metabolism, lower amino acid PR:PROJECT_SUMMARY metabolism, and higher oxidative stress before the infection. Using a novel PR:PROJECT_SUMMARY taxon-specific measure of DISruption in COrrelations (DISCO) with various data PR:PROJECT_SUMMARY modalities, we identified several gut and oral species with disrupted PR:PROJECT_SUMMARY correlations prior to HIV-1 infection. Application of DISCO to external datasets PR:PROJECT_SUMMARY revealed that Prevotella spp. are consistently disrupted in their correlations PR:PROJECT_SUMMARY across multiple cohorts prior to or following HIV-1 infection. PR:INSTITUTE National Institute of Environmental Health Sciences PR:LAST_NAME Fouladi PR:FIRST_NAME Farnaz PR:ADDRESS 111 T.W. Alexander Drive, Durham, NC 27709 PR:EMAIL farnaz.fouladi@nih.gov PR:PHONE 984-287-4663 PR:DOI http://dx.doi.org/10.21228/M8QN9C #STUDY ST:STUDY_TITLE Plasma Metabolomics Profiling in Men Who Have Sex with Men Before HIV-1 ST:STUDY_TITLE Infection ST:STUDY_SUMMARY This study includes Men who have Sex with Men (MSM) enrolled in the Multicenter ST:STUDY_SUMMARY AIDS Cohort study (MACS) between 1984-1985. All participants were HIV-1-negative ST:STUDY_SUMMARY during their first MACS clinic visit, when samples were collected. Metabolic ST:STUDY_SUMMARY profiles are compared between those who were infected with HIV-1 by their second ST:STUDY_SUMMARY study clinic visit approximately 6 months later (termed Pre-HIV) and those who ST:STUDY_SUMMARY remained HIV-negative (termed Non-HIV) at their second MACS clinic visit. Data ST:STUDY_SUMMARY Availability: Access to individual-level data from the MACS/WIHS Combined Cohort ST:STUDY_SUMMARY Study Data (MWCCS) may be obtained upon review and approval of a MWCCS concept ST:STUDY_SUMMARY sheet. Links and instructions for online concept sheet submission are on the ST:STUDY_SUMMARY study website (http://mwccs.org/). Once the concept sheet is approved, please ST:STUDY_SUMMARY contact Dr. Yue Chen (cheny@pitt.edu) to obtain the metadata. ST:INSTITUTE National Institute of Environmental Health Sciences ST:LAST_NAME Fouladi ST:FIRST_NAME Farnaz ST:ADDRESS 111 T.W. Alexander Drive, Durham, NC 27709 ST:EMAIL farnaz.fouladi@nih.gov ST:PHONE 984-287-4663 ST:SUBMIT_DATE 2025-09-17 #SUBJECT SU:SUBJECT_TYPE Human SU:SUBJECT_SPECIES Homo sapiens SU:TAXONOMY_ID 9606 #SUBJECT_SAMPLE_FACTORS: SUBJECT(optional)[tab]SAMPLE[tab]FACTORS(NAME:VALUE pairs separated by |)[tab]Additional sample data SUBJECT_SAMPLE_FACTORS DUMMY82 1 Sample source:Plasma | Group:A RAW_FILE_NAME(Raw_file_name_positive)=1.raw; RAW_FILE_NAME(Raw_file_name_negative)=N1.raw SUBJECT_SAMPLE_FACTORS DUMMY20 101 Sample source:Plasma | Group:A RAW_FILE_NAME(Raw_file_name_positive)=101.raw; RAW_FILE_NAME(Raw_file_name_negative)=N101.raw SUBJECT_SAMPLE_FACTORS DUMMY145 103 Sample source:Plasma | Group:A RAW_FILE_NAME(Raw_file_name_positive)=103.raw; RAW_FILE_NAME(Raw_file_name_negative)=N103.raw SUBJECT_SAMPLE_FACTORS DUMMY148 106 Sample source:Plasma | Group:A RAW_FILE_NAME(Raw_file_name_positive)=106.raw; RAW_FILE_NAME(Raw_file_name_negative)=N106.raw SUBJECT_SAMPLE_FACTORS DUMMY68 107 Sample source:Plasma | Group:A RAW_FILE_NAME(Raw_file_name_positive)=107.raw; RAW_FILE_NAME(Raw_file_name_negative)=N107.raw SUBJECT_SAMPLE_FACTORS DUMMY77 109 Sample source:Plasma | Group:A RAW_FILE_NAME(Raw_file_name_positive)=109.raw; RAW_FILE_NAME(Raw_file_name_negative)=N109.raw SUBJECT_SAMPLE_FACTORS DUMMY87 11 Sample source:Plasma | Group:A RAW_FILE_NAME(Raw_file_name_positive)=11.raw; RAW_FILE_NAME(Raw_file_name_negative)=N11.raw SUBJECT_SAMPLE_FACTORS DUMMY149 111 Sample source:Plasma | Group:A RAW_FILE_NAME(Raw_file_name_positive)=111.raw; RAW_FILE_NAME(Raw_file_name_negative)=N111.raw SUBJECT_SAMPLE_FACTORS DUMMY39 112 Sample source:Plasma | Group:A RAW_FILE_NAME(Raw_file_name_positive)=112.raw; RAW_FILE_NAME(Raw_file_name_negative)=N112.raw SUBJECT_SAMPLE_FACTORS DUMMY151 115 Sample source:Plasma | Group:A RAW_FILE_NAME(Raw_file_name_positive)=115.raw; RAW_FILE_NAME(Raw_file_name_negative)=N115.raw SUBJECT_SAMPLE_FACTORS DUMMY35 116 Sample source:Plasma | Group:A RAW_FILE_NAME(Raw_file_name_positive)=116.raw; RAW_FILE_NAME(Raw_file_name_negative)=N116.raw SUBJECT_SAMPLE_FACTORS DUMMY69 118 Sample source:Plasma | Group:A RAW_FILE_NAME(Raw_file_name_positive)=118.raw; RAW_FILE_NAME(Raw_file_name_negative)=N118.raw SUBJECT_SAMPLE_FACTORS DUMMY152 122 Sample source:Plasma | Group:A RAW_FILE_NAME(Raw_file_name_positive)=122.raw; RAW_FILE_NAME(Raw_file_name_negative)=N122.raw SUBJECT_SAMPLE_FACTORS DUMMY36 123 Sample source:Plasma | Group:A RAW_FILE_NAME(Raw_file_name_positive)=123.raw; RAW_FILE_NAME(Raw_file_name_negative)=N123.raw SUBJECT_SAMPLE_FACTORS DUMMY70 125 Sample source:Plasma | Group:A RAW_FILE_NAME(Raw_file_name_positive)=125.raw; RAW_FILE_NAME(Raw_file_name_negative)=N125.raw SUBJECT_SAMPLE_FACTORS DUMMY153 127 Sample source:Plasma | Group:A RAW_FILE_NAME(Raw_file_name_positive)=127.raw; RAW_FILE_NAME(Raw_file_name_negative)=N127.raw SUBJECT_SAMPLE_FACTORS DUMMY154 128 Sample source:Plasma | Group:A RAW_FILE_NAME(Raw_file_name_positive)=128.raw; RAW_FILE_NAME(Raw_file_name_negative)=N128.raw SUBJECT_SAMPLE_FACTORS DUMMY61 129 Sample source:Plasma | Group:A RAW_FILE_NAME(Raw_file_name_positive)=129.raw; RAW_FILE_NAME(Raw_file_name_negative)=N129.raw SUBJECT_SAMPLE_FACTORS DUMMY113 13 Sample source:Plasma | Group:A RAW_FILE_NAME(Raw_file_name_positive)=13.raw; RAW_FILE_NAME(Raw_file_name_negative)=N13.raw SUBJECT_SAMPLE_FACTORS DUMMY155 131 Sample source:Plasma | Group:A RAW_FILE_NAME(Raw_file_name_positive)=131.raw; RAW_FILE_NAME(Raw_file_name_negative)=N131.raw SUBJECT_SAMPLE_FACTORS DUMMY156 132 Sample source:Plasma | Group:A RAW_FILE_NAME(Raw_file_name_positive)=132.raw; RAW_FILE_NAME(Raw_file_name_negative)=N132.raw SUBJECT_SAMPLE_FACTORS DUMMY55 133 Sample source:Plasma | Group:A RAW_FILE_NAME(Raw_file_name_positive)=133.raw; RAW_FILE_NAME(Raw_file_name_negative)=N133.raw SUBJECT_SAMPLE_FACTORS DUMMY157 135 Sample source:Plasma | Group:A RAW_FILE_NAME(Raw_file_name_positive)=135.raw; RAW_FILE_NAME(Raw_file_name_negative)=N135.raw SUBJECT_SAMPLE_FACTORS DUMMY56 136 Sample source:Plasma | Group:A RAW_FILE_NAME(Raw_file_name_positive)=136.raw; RAW_FILE_NAME(Raw_file_name_negative)=N136.raw SUBJECT_SAMPLE_FACTORS DUMMY44 138 Sample source:Plasma | Group:A RAW_FILE_NAME(Raw_file_name_positive)=138.raw; RAW_FILE_NAME(Raw_file_name_negative)=N138.raw SUBJECT_SAMPLE_FACTORS DUMMY88 14 Sample source:Plasma | Group:A RAW_FILE_NAME(Raw_file_name_positive)=14.raw; RAW_FILE_NAME(Raw_file_name_negative)=N14.raw SUBJECT_SAMPLE_FACTORS DUMMY57 140 Sample source:Plasma | Group:A RAW_FILE_NAME(Raw_file_name_positive)=140.raw; RAW_FILE_NAME(Raw_file_name_negative)=N140.raw SUBJECT_SAMPLE_FACTORS DUMMY159 143 Sample source:Plasma | Group:A RAW_FILE_NAME(Raw_file_name_positive)=143.raw; RAW_FILE_NAME(Raw_file_name_negative)=N143.raw SUBJECT_SAMPLE_FACTORS DUMMY160 144 Sample source:Plasma | Group:A RAW_FILE_NAME(Raw_file_name_positive)=144.raw; RAW_FILE_NAME(Raw_file_name_negative)=N144.raw SUBJECT_SAMPLE_FACTORS DUMMY162 146 Sample source:Plasma | Group:A RAW_FILE_NAME(Raw_file_name_positive)=146.raw; RAW_FILE_NAME(Raw_file_name_negative)=N146.raw SUBJECT_SAMPLE_FACTORS DUMMY45 147 Sample source:Plasma | Group:A RAW_FILE_NAME(Raw_file_name_positive)=147.raw; RAW_FILE_NAME(Raw_file_name_negative)=N147.raw SUBJECT_SAMPLE_FACTORS DUMMY58 149 Sample source:Plasma | Group:A RAW_FILE_NAME(Raw_file_name_positive)=149.raw; RAW_FILE_NAME(Raw_file_name_negative)=N149.raw SUBJECT_SAMPLE_FACTORS DUMMY59 151 Sample source:Plasma | Group:A RAW_FILE_NAME(Raw_file_name_positive)=151.raw; RAW_FILE_NAME(Raw_file_name_negative)=N151.raw SUBJECT_SAMPLE_FACTORS DUMMY163 153 Sample source:Plasma | Group:A RAW_FILE_NAME(Raw_file_name_positive)=153.raw; RAW_FILE_NAME(Raw_file_name_negative)=N153.raw SUBJECT_SAMPLE_FACTORS DUMMY72 154 Sample source:Plasma | Group:A RAW_FILE_NAME(Raw_file_name_positive)=154.raw; RAW_FILE_NAME(Raw_file_name_negative)=N154.raw SUBJECT_SAMPLE_FACTORS DUMMY164 156 Sample source:Plasma | Group:A RAW_FILE_NAME(Raw_file_name_positive)=156.raw; RAW_FILE_NAME(Raw_file_name_negative)=N156.raw SUBJECT_SAMPLE_FACTORS DUMMY31 157 Sample source:Plasma | Group:A RAW_FILE_NAME(Raw_file_name_positive)=157.raw; RAW_FILE_NAME(Raw_file_name_negative)=N157.raw SUBJECT_SAMPLE_FACTORS DUMMY165 159 Sample source:Plasma | Group:A RAW_FILE_NAME(Raw_file_name_positive)=159.raw; RAW_FILE_NAME(Raw_file_name_negative)=N159.raw SUBJECT_SAMPLE_FACTORS DUMMY89 16 Sample source:Plasma | Group:A RAW_FILE_NAME(Raw_file_name_positive)=16.raw; RAW_FILE_NAME(Raw_file_name_negative)=N16.raw SUBJECT_SAMPLE_FACTORS DUMMY166 160 Sample source:Plasma | Group:A RAW_FILE_NAME(Raw_file_name_positive)=160.raw; RAW_FILE_NAME(Raw_file_name_negative)=N160.raw SUBJECT_SAMPLE_FACTORS DUMMY34 161 Sample source:Plasma | Group:A RAW_FILE_NAME(Raw_file_name_positive)=161.raw; RAW_FILE_NAME(Raw_file_name_negative)=N161.raw SUBJECT_SAMPLE_FACTORS DUMMY1 166 Sample source:Plasma | Group:A RAW_FILE_NAME(Raw_file_name_positive)=166.raw; RAW_FILE_NAME(Raw_file_name_negative)=N166.raw SUBJECT_SAMPLE_FACTORS DUMMY170 168 Sample source:Plasma | Group:A RAW_FILE_NAME(Raw_file_name_positive)=168.raw; RAW_FILE_NAME(Raw_file_name_negative)=N168.raw SUBJECT_SAMPLE_FACTORS DUMMY171 169 Sample source:Plasma | Group:A RAW_FILE_NAME(Raw_file_name_positive)=169.raw; RAW_FILE_NAME(Raw_file_name_negative)=N169.raw SUBJECT_SAMPLE_FACTORS DUMMY2 170 Sample source:Plasma | Group:A RAW_FILE_NAME(Raw_file_name_positive)=170.raw; RAW_FILE_NAME(Raw_file_name_negative)=N170.raw SUBJECT_SAMPLE_FACTORS DUMMY3 172 Sample source:Plasma | Group:A RAW_FILE_NAME(Raw_file_name_positive)=172.raw; RAW_FILE_NAME(Raw_file_name_negative)=N172.raw SUBJECT_SAMPLE_FACTORS DUMMY4 174 Sample source:Plasma | Group:A RAW_FILE_NAME(Raw_file_name_positive)=174.raw; RAW_FILE_NAME(Raw_file_name_negative)=N174.raw SUBJECT_SAMPLE_FACTORS DUMMY62 176 Sample source:Plasma | Group:A RAW_FILE_NAME(Raw_file_name_positive)=176.raw; RAW_FILE_NAME(Raw_file_name_negative)=N176.raw SUBJECT_SAMPLE_FACTORS DUMMY6 178 Sample source:Plasma | Group:A RAW_FILE_NAME(Raw_file_name_positive)=178.raw; RAW_FILE_NAME(Raw_file_name_negative)=N178.raw SUBJECT_SAMPLE_FACTORS DUMMY114 18 Sample source:Plasma | Group:A RAW_FILE_NAME(Raw_file_name_positive)=18.raw; RAW_FILE_NAME(Raw_file_name_negative)=N18.raw SUBJECT_SAMPLE_FACTORS DUMMY78 180 Sample source:Plasma | Group:A RAW_FILE_NAME(Raw_file_name_positive)=180.raw; RAW_FILE_NAME(Raw_file_name_negative)=N180.raw SUBJECT_SAMPLE_FACTORS DUMMY5 182 Sample source:Plasma | Group:A RAW_FILE_NAME(Raw_file_name_positive)=182.raw; RAW_FILE_NAME(Raw_file_name_negative)=N182.raw SUBJECT_SAMPLE_FACTORS DUMMY172 184 Sample source:Plasma | Group:A RAW_FILE_NAME(Raw_file_name_positive)=184.raw; RAW_FILE_NAME(Raw_file_name_negative)=N184.raw SUBJECT_SAMPLE_FACTORS DUMMY174 186 Sample source:Plasma | Group:A RAW_FILE_NAME(Raw_file_name_positive)=186.raw; RAW_FILE_NAME(Raw_file_name_negative)=N186.raw SUBJECT_SAMPLE_FACTORS DUMMY175 187 Sample source:Plasma | Group:A RAW_FILE_NAME(Raw_file_name_positive)=187.raw; RAW_FILE_NAME(Raw_file_name_negative)=N187.raw SUBJECT_SAMPLE_FACTORS DUMMY176 188 Sample source:Plasma | Group:A RAW_FILE_NAME(Raw_file_name_positive)=188.raw; RAW_FILE_NAME(Raw_file_name_negative)=N188.raw SUBJECT_SAMPLE_FACTORS DUMMY177 189 Sample source:Plasma | Group:A RAW_FILE_NAME(Raw_file_name_positive)=189.raw; RAW_FILE_NAME(Raw_file_name_negative)=N189.raw SUBJECT_SAMPLE_FACTORS DUMMY90 19 Sample source:Plasma | Group:A RAW_FILE_NAME(Raw_file_name_positive)=19.raw; RAW_FILE_NAME(Raw_file_name_negative)=N19.raw SUBJECT_SAMPLE_FACTORS DUMMY178 190 Sample source:Plasma | Group:A RAW_FILE_NAME(Raw_file_name_positive)=190.raw; RAW_FILE_NAME(Raw_file_name_negative)=N190.raw SUBJECT_SAMPLE_FACTORS DUMMY179 191 Sample source:Plasma | Group:A RAW_FILE_NAME(Raw_file_name_positive)=191.raw; RAW_FILE_NAME(Raw_file_name_negative)=N191.raw SUBJECT_SAMPLE_FACTORS DUMMY180 192 Sample source:Plasma | Group:A RAW_FILE_NAME(Raw_file_name_positive)=192.raw; RAW_FILE_NAME(Raw_file_name_negative)=N192.raw SUBJECT_SAMPLE_FACTORS DUMMY181 193 Sample source:Plasma | Group:A RAW_FILE_NAME(Raw_file_name_positive)=193.raw; RAW_FILE_NAME(Raw_file_name_negative)=N193.raw SUBJECT_SAMPLE_FACTORS DUMMY182 194 Sample source:Plasma | Group:A RAW_FILE_NAME(Raw_file_name_positive)=194.raw; RAW_FILE_NAME(Raw_file_name_negative)=N194.raw SUBJECT_SAMPLE_FACTORS DUMMY183 195 Sample source:Plasma | Group:A RAW_FILE_NAME(Raw_file_name_positive)=195.raw; RAW_FILE_NAME(Raw_file_name_negative)=N195.raw SUBJECT_SAMPLE_FACTORS DUMMY184 196 Sample source:Plasma | Group:A RAW_FILE_NAME(Raw_file_name_positive)=196.raw; RAW_FILE_NAME(Raw_file_name_negative)=N196.raw SUBJECT_SAMPLE_FACTORS DUMMY79 197 Sample source:Plasma | Group:A RAW_FILE_NAME(Raw_file_name_positive)=197.raw; RAW_FILE_NAME(Raw_file_name_negative)=N197.raw SUBJECT_SAMPLE_FACTORS DUMMY185 199 Sample source:Plasma | Group:A RAW_FILE_NAME(Raw_file_name_positive)=199.raw; RAW_FILE_NAME(Raw_file_name_negative)=N199.raw SUBJECT_SAMPLE_FACTORS DUMMY186 200 Sample source:Plasma | Group:A RAW_FILE_NAME(Raw_file_name_positive)=200.raw; RAW_FILE_NAME(Raw_file_name_negative)=N200.raw SUBJECT_SAMPLE_FACTORS DUMMY37 203 Sample source:Plasma | Group:A RAW_FILE_NAME(Raw_file_name_positive)=203.raw; RAW_FILE_NAME(Raw_file_name_negative)=N203.raw SUBJECT_SAMPLE_FACTORS DUMMY80 205 Sample source:Plasma | Group:A RAW_FILE_NAME(Raw_file_name_positive)=205.raw; RAW_FILE_NAME(Raw_file_name_negative)=N205.raw SUBJECT_SAMPLE_FACTORS DUMMY187 207 Sample source:Plasma | Group:A RAW_FILE_NAME(Raw_file_name_positive)=207.raw; RAW_FILE_NAME(Raw_file_name_negative)=N207.raw SUBJECT_SAMPLE_FACTORS DUMMY21 208 Sample source:Plasma | Group:A RAW_FILE_NAME(Raw_file_name_positive)=208.raw; RAW_FILE_NAME(Raw_file_name_negative)=N208.raw SUBJECT_SAMPLE_FACTORS DUMMY91 21 Sample source:Plasma | Group:A RAW_FILE_NAME(Raw_file_name_positive)=21.raw; RAW_FILE_NAME(Raw_file_name_negative)=N21.raw SUBJECT_SAMPLE_FACTORS DUMMY22 210 Sample source:Plasma | Group:A RAW_FILE_NAME(Raw_file_name_positive)=210.raw; RAW_FILE_NAME(Raw_file_name_negative)=N210.raw SUBJECT_SAMPLE_FACTORS DUMMY40 212 Sample source:Plasma | Group:A RAW_FILE_NAME(Raw_file_name_positive)=212.raw; RAW_FILE_NAME(Raw_file_name_negative)=N212.raw SUBJECT_SAMPLE_FACTORS DUMMY41 214 Sample source:Plasma | Group:A RAW_FILE_NAME(Raw_file_name_positive)=214.raw; RAW_FILE_NAME(Raw_file_name_negative)=N214.raw SUBJECT_SAMPLE_FACTORS DUMMY71 216 Sample source:Plasma | Group:A RAW_FILE_NAME(Raw_file_name_positive)=216.raw; RAW_FILE_NAME(Raw_file_name_negative)=N216.raw SUBJECT_SAMPLE_FACTORS DUMMY188 218 Sample source:Plasma | Group:A RAW_FILE_NAME(Raw_file_name_positive)=218.raw; RAW_FILE_NAME(Raw_file_name_negative)=N218.raw SUBJECT_SAMPLE_FACTORS DUMMY189 219 Sample source:Plasma | Group:A RAW_FILE_NAME(Raw_file_name_positive)=219.raw; RAW_FILE_NAME(Raw_file_name_negative)=N219.raw SUBJECT_SAMPLE_FACTORS DUMMY190 220 Sample source:Plasma | Group:A RAW_FILE_NAME(Raw_file_name_positive)=220.raw; RAW_FILE_NAME(Raw_file_name_negative)=N220.raw SUBJECT_SAMPLE_FACTORS DUMMY191 221 Sample source:Plasma | Group:A RAW_FILE_NAME(Raw_file_name_positive)=221.raw; RAW_FILE_NAME(Raw_file_name_negative)=N221.raw SUBJECT_SAMPLE_FACTORS DUMMY23 222 Sample source:Plasma | Group:A RAW_FILE_NAME(Raw_file_name_positive)=222.raw; RAW_FILE_NAME(Raw_file_name_negative)=N222.raw SUBJECT_SAMPLE_FACTORS DUMMY192 224 Sample source:Plasma | Group:A RAW_FILE_NAME(Raw_file_name_positive)=224.raw; RAW_FILE_NAME(Raw_file_name_negative)=N224.raw SUBJECT_SAMPLE_FACTORS DUMMY63 225 Sample source:Plasma | Group:A RAW_FILE_NAME(Raw_file_name_positive)=225.raw; RAW_FILE_NAME(Raw_file_name_negative)=N225.raw SUBJECT_SAMPLE_FACTORS DUMMY193 227 Sample source:Plasma | Group:A RAW_FILE_NAME(Raw_file_name_positive)=227.raw; RAW_FILE_NAME(Raw_file_name_negative)=N227.raw SUBJECT_SAMPLE_FACTORS DUMMY25 228 Sample source:Plasma | Group:A RAW_FILE_NAME(Raw_file_name_positive)=228.raw; RAW_FILE_NAME(Raw_file_name_negative)=N228.raw SUBJECT_SAMPLE_FACTORS DUMMY92 23 Sample source:Plasma | Group:A RAW_FILE_NAME(Raw_file_name_positive)=23.raw; RAW_FILE_NAME(Raw_file_name_negative)=N23.raw SUBJECT_SAMPLE_FACTORS DUMMY26 231 Sample source:Plasma | Group:A RAW_FILE_NAME(Raw_file_name_positive)=231.raw; RAW_FILE_NAME(Raw_file_name_negative)=N231.raw SUBJECT_SAMPLE_FACTORS DUMMY60 233 Sample source:Plasma | Group:A RAW_FILE_NAME(Raw_file_name_positive)=233.raw; RAW_FILE_NAME(Raw_file_name_negative)=N233.raw SUBJECT_SAMPLE_FACTORS DUMMY195 235 Sample source:Plasma | Group:A RAW_FILE_NAME(Raw_file_name_positive)=235.raw; RAW_FILE_NAME(Raw_file_name_negative)=N235.raw SUBJECT_SAMPLE_FACTORS DUMMY30 236 Sample source:Plasma | Group:A RAW_FILE_NAME(Raw_file_name_positive)=236.raw; RAW_FILE_NAME(Raw_file_name_negative)=N236.raw SUBJECT_SAMPLE_FACTORS DUMMY196 238 Sample source:Plasma | Group:A RAW_FILE_NAME(Raw_file_name_positive)=238.raw; RAW_FILE_NAME(Raw_file_name_negative)=N238.raw SUBJECT_SAMPLE_FACTORS DUMMY197 239 Sample source:Plasma | Group:A RAW_FILE_NAME(Raw_file_name_positive)=239.raw; RAW_FILE_NAME(Raw_file_name_negative)=N239.raw SUBJECT_SAMPLE_FACTORS DUMMY198 240 Sample source:Plasma | Group:A RAW_FILE_NAME(Raw_file_name_positive)=240.raw; RAW_FILE_NAME(Raw_file_name_negative)=N240.raw SUBJECT_SAMPLE_FACTORS DUMMY24 241 Sample source:Plasma | Group:A RAW_FILE_NAME(Raw_file_name_positive)=241.raw; RAW_FILE_NAME(Raw_file_name_negative)=N241.raw SUBJECT_SAMPLE_FACTORS DUMMY27 243 Sample source:Plasma | Group:A RAW_FILE_NAME(Raw_file_name_positive)=243.raw; RAW_FILE_NAME(Raw_file_name_negative)=N243.raw SUBJECT_SAMPLE_FACTORS DUMMY199 245 Sample source:Plasma | Group:A RAW_FILE_NAME(Raw_file_name_positive)=245.raw; RAW_FILE_NAME(Raw_file_name_negative)=N245.raw SUBJECT_SAMPLE_FACTORS DUMMY200 246 Sample source:Plasma | Group:A RAW_FILE_NAME(Raw_file_name_positive)=246.raw; RAW_FILE_NAME(Raw_file_name_negative)=N246.raw SUBJECT_SAMPLE_FACTORS DUMMY201 247 Sample source:Plasma | Group:A RAW_FILE_NAME(Raw_file_name_positive)=247.raw; RAW_FILE_NAME(Raw_file_name_negative)=N247.raw SUBJECT_SAMPLE_FACTORS DUMMY202 248 Sample source:Plasma | Group:A RAW_FILE_NAME(Raw_file_name_positive)=248.raw; RAW_FILE_NAME(Raw_file_name_negative)=N248.raw SUBJECT_SAMPLE_FACTORS DUMMY46 249 Sample source:Plasma | Group:A RAW_FILE_NAME(Raw_file_name_positive)=249.raw; RAW_FILE_NAME(Raw_file_name_negative)=N249.raw SUBJECT_SAMPLE_FACTORS DUMMY93 25 Sample source:Plasma | Group:A RAW_FILE_NAME(Raw_file_name_positive)=25.raw; RAW_FILE_NAME(Raw_file_name_negative)=N25.raw SUBJECT_SAMPLE_FACTORS DUMMY203 251 Sample source:Plasma | Group:A RAW_FILE_NAME(Raw_file_name_positive)=251.raw; RAW_FILE_NAME(Raw_file_name_negative)=N251.raw SUBJECT_SAMPLE_FACTORS DUMMY204 252 Sample source:Plasma | Group:A RAW_FILE_NAME(Raw_file_name_positive)=252.raw; RAW_FILE_NAME(Raw_file_name_negative)=N252.raw SUBJECT_SAMPLE_FACTORS DUMMY205 253 Sample source:Plasma | Group:A RAW_FILE_NAME(Raw_file_name_positive)=253.raw; RAW_FILE_NAME(Raw_file_name_negative)=N253.raw SUBJECT_SAMPLE_FACTORS DUMMY206 254 Sample source:Plasma | Group:A RAW_FILE_NAME(Raw_file_name_positive)=254.raw; RAW_FILE_NAME(Raw_file_name_negative)=N254.raw SUBJECT_SAMPLE_FACTORS DUMMY29 255 Sample source:Plasma | Group:A RAW_FILE_NAME(Raw_file_name_positive)=255.raw; RAW_FILE_NAME(Raw_file_name_negative)=N255.raw SUBJECT_SAMPLE_FACTORS DUMMY28 257 Sample source:Plasma | Group:A RAW_FILE_NAME(Raw_file_name_positive)=257.raw; RAW_FILE_NAME(Raw_file_name_negative)=N257.raw SUBJECT_SAMPLE_FACTORS DUMMY207 259 Sample source:Plasma | Group:A RAW_FILE_NAME(Raw_file_name_positive)=259.raw; RAW_FILE_NAME(Raw_file_name_negative)=N259.raw SUBJECT_SAMPLE_FACTORS DUMMY208 262 Sample source:Plasma | Group:A RAW_FILE_NAME(Raw_file_name_positive)=262.raw; RAW_FILE_NAME(Raw_file_name_negative)=N262.raw SUBJECT_SAMPLE_FACTORS DUMMY209 263 Sample source:Plasma | Group:A RAW_FILE_NAME(Raw_file_name_positive)=263.raw; RAW_FILE_NAME(Raw_file_name_negative)=N263.raw SUBJECT_SAMPLE_FACTORS DUMMY210 264 Sample source:Plasma | Group:A RAW_FILE_NAME(Raw_file_name_positive)=264.raw; RAW_FILE_NAME(Raw_file_name_negative)=N264.raw SUBJECT_SAMPLE_FACTORS DUMMY211 265 Sample source:Plasma | Group:A RAW_FILE_NAME(Raw_file_name_positive)=265.raw; RAW_FILE_NAME(Raw_file_name_negative)=N265.raw SUBJECT_SAMPLE_FACTORS DUMMY212 266 Sample source:Plasma | Group:A RAW_FILE_NAME(Raw_file_name_positive)=266.raw; RAW_FILE_NAME(Raw_file_name_negative)=N266.raw SUBJECT_SAMPLE_FACTORS DUMMY214 268 Sample source:Plasma | Group:A RAW_FILE_NAME(Raw_file_name_positive)=268.raw; RAW_FILE_NAME(Raw_file_name_negative)=N268.raw SUBJECT_SAMPLE_FACTORS DUMMY94 27 Sample source:Plasma | Group:A RAW_FILE_NAME(Raw_file_name_positive)=27.raw; RAW_FILE_NAME(Raw_file_name_negative)=N27.raw SUBJECT_SAMPLE_FACTORS DUMMY216 270 Sample source:Plasma | Group:A RAW_FILE_NAME(Raw_file_name_positive)=270.raw; RAW_FILE_NAME(Raw_file_name_negative)=N270.raw SUBJECT_SAMPLE_FACTORS DUMMY217 271 Sample source:Plasma | Group:A RAW_FILE_NAME(Raw_file_name_positive)=271.raw; RAW_FILE_NAME(Raw_file_name_negative)=N271.raw SUBJECT_SAMPLE_FACTORS DUMMY42 272 Sample source:Plasma | Group:A RAW_FILE_NAME(Raw_file_name_positive)=272.raw; RAW_FILE_NAME(Raw_file_name_negative)=N272.raw SUBJECT_SAMPLE_FACTORS DUMMY16 274 Sample source:Plasma | Group:A RAW_FILE_NAME(Raw_file_name_positive)=274.raw; RAW_FILE_NAME(Raw_file_name_negative)=N274.raw SUBJECT_SAMPLE_FACTORS DUMMY53 276 Sample source:Plasma | Group:A RAW_FILE_NAME(Raw_file_name_positive)=276.raw; RAW_FILE_NAME(Raw_file_name_negative)=N276.raw SUBJECT_SAMPLE_FACTORS DUMMY218 278 Sample source:Plasma | Group:A RAW_FILE_NAME(Raw_file_name_positive)=278.raw; RAW_FILE_NAME(Raw_file_name_negative)=N278.raw SUBJECT_SAMPLE_FACTORS DUMMY15 279 Sample source:Plasma | Group:A RAW_FILE_NAME(Raw_file_name_positive)=279.raw; RAW_FILE_NAME(Raw_file_name_negative)=N279.raw SUBJECT_SAMPLE_FACTORS DUMMY14 281 Sample source:Plasma | Group:A RAW_FILE_NAME(Raw_file_name_positive)=281.raw; RAW_FILE_NAME(Raw_file_name_negative)=N281.raw SUBJECT_SAMPLE_FACTORS DUMMY219 283 Sample source:Plasma | Group:A RAW_FILE_NAME(Raw_file_name_positive)=283.raw; RAW_FILE_NAME(Raw_file_name_negative)=N283.raw SUBJECT_SAMPLE_FACTORS DUMMY73 284 Sample source:Plasma | Group:A RAW_FILE_NAME(Raw_file_name_positive)=284.raw; RAW_FILE_NAME(Raw_file_name_negative)=N284.raw SUBJECT_SAMPLE_FACTORS DUMMY7 286 Sample source:Plasma | Group:A RAW_FILE_NAME(Raw_file_name_positive)=286.raw; RAW_FILE_NAME(Raw_file_name_negative)=N286.raw SUBJECT_SAMPLE_FACTORS DUMMY220 288 Sample source:Plasma | Group:A RAW_FILE_NAME(Raw_file_name_positive)=288.raw; RAW_FILE_NAME(Raw_file_name_negative)=N288.raw SUBJECT_SAMPLE_FACTORS DUMMY95 29 Sample source:Plasma | Group:A RAW_FILE_NAME(Raw_file_name_positive)=29.raw; RAW_FILE_NAME(Raw_file_name_negative)=N29.raw SUBJECT_SAMPLE_FACTORS DUMMY10 290 Sample source:Plasma | Group:A RAW_FILE_NAME(Raw_file_name_positive)=290.raw; RAW_FILE_NAME(Raw_file_name_negative)=N290.raw SUBJECT_SAMPLE_FACTORS DUMMY222 292 Sample source:Plasma | Group:A RAW_FILE_NAME(Raw_file_name_positive)=292.raw; RAW_FILE_NAME(Raw_file_name_negative)=N292.raw SUBJECT_SAMPLE_FACTORS DUMMY9 295 Sample source:Plasma | Group:A RAW_FILE_NAME(Raw_file_name_positive)=295.raw; RAW_FILE_NAME(Raw_file_name_negative)=N295.raw SUBJECT_SAMPLE_FACTORS DUMMY223 299 Sample source:Plasma | Group:A RAW_FILE_NAME(Raw_file_name_positive)=299.raw; RAW_FILE_NAME(Raw_file_name_negative)=N299.raw SUBJECT_SAMPLE_FACTORS DUMMY83 3 Sample source:Plasma | Group:A RAW_FILE_NAME(Raw_file_name_positive)=3.raw; RAW_FILE_NAME(Raw_file_name_negative)=N3.raw SUBJECT_SAMPLE_FACTORS DUMMY225 301 Sample source:Plasma | Group:A RAW_FILE_NAME(Raw_file_name_positive)=301.raw; RAW_FILE_NAME(Raw_file_name_negative)=N301.raw SUBJECT_SAMPLE_FACTORS DUMMY64 302 Sample source:Plasma | Group:A RAW_FILE_NAME(Raw_file_name_positive)=302.raw; RAW_FILE_NAME(Raw_file_name_negative)=N302.raw SUBJECT_SAMPLE_FACTORS DUMMY226 304 Sample source:Plasma | Group:A RAW_FILE_NAME(Raw_file_name_positive)=304.raw; RAW_FILE_NAME(Raw_file_name_negative)=N304.raw SUBJECT_SAMPLE_FACTORS DUMMY65 305 Sample source:Plasma | Group:A RAW_FILE_NAME(Raw_file_name_positive)=305.raw; RAW_FILE_NAME(Raw_file_name_negative)=N305.raw SUBJECT_SAMPLE_FACTORS DUMMY227 307 Sample source:Plasma | Group:A RAW_FILE_NAME(Raw_file_name_positive)=307.raw; RAW_FILE_NAME(Raw_file_name_negative)=N307.raw SUBJECT_SAMPLE_FACTORS DUMMY12 308 Sample source:Plasma | Group:A RAW_FILE_NAME(Raw_file_name_positive)=308.raw; RAW_FILE_NAME(Raw_file_name_negative)=N308.raw SUBJECT_SAMPLE_FACTORS DUMMY96 31 Sample source:Plasma | Group:A RAW_FILE_NAME(Raw_file_name_positive)=31.raw; RAW_FILE_NAME(Raw_file_name_negative)=N31.raw SUBJECT_SAMPLE_FACTORS DUMMY13 310 Sample source:Plasma | Group:A RAW_FILE_NAME(Raw_file_name_positive)=310.raw; RAW_FILE_NAME(Raw_file_name_negative)=N310.raw SUBJECT_SAMPLE_FACTORS DUMMY228 312 Sample source:Plasma | Group:A RAW_FILE_NAME(Raw_file_name_positive)=312.raw; RAW_FILE_NAME(Raw_file_name_negative)=N312.raw SUBJECT_SAMPLE_FACTORS DUMMY66 313 Sample source:Plasma | Group:A RAW_FILE_NAME(Raw_file_name_positive)=313.raw; RAW_FILE_NAME(Raw_file_name_negative)=N313.raw SUBJECT_SAMPLE_FACTORS DUMMY231 317 Sample source:Plasma | Group:A RAW_FILE_NAME(Raw_file_name_positive)=317.raw; RAW_FILE_NAME(Raw_file_name_negative)=N317.raw SUBJECT_SAMPLE_FACTORS DUMMY232 318 Sample source:Plasma | Group:A RAW_FILE_NAME(Raw_file_name_positive)=318.raw; RAW_FILE_NAME(Raw_file_name_negative)=N318.raw SUBJECT_SAMPLE_FACTORS DUMMY17 319 Sample source:Plasma | Group:A RAW_FILE_NAME(Raw_file_name_positive)=319.raw; RAW_FILE_NAME(Raw_file_name_negative)=N319.raw SUBJECT_SAMPLE_FACTORS DUMMY74 321 Sample source:Plasma | Group:A RAW_FILE_NAME(Raw_file_name_positive)=321.raw; RAW_FILE_NAME(Raw_file_name_negative)=N321.raw SUBJECT_SAMPLE_FACTORS DUMMY233 323 Sample source:Plasma | Group:A RAW_FILE_NAME(Raw_file_name_positive)=323.raw; RAW_FILE_NAME(Raw_file_name_negative)=N323.raw SUBJECT_SAMPLE_FACTORS DUMMY48 324 Sample source:Plasma | Group:A RAW_FILE_NAME(Raw_file_name_positive)=324.raw; RAW_FILE_NAME(Raw_file_name_negative)=N324.raw SUBJECT_SAMPLE_FACTORS DUMMY43 326 Sample source:Plasma | Group:A RAW_FILE_NAME(Raw_file_name_positive)=326.raw; RAW_FILE_NAME(Raw_file_name_negative)=N326.raw SUBJECT_SAMPLE_FACTORS DUMMY234 328 Sample source:Plasma | Group:A RAW_FILE_NAME(Raw_file_name_positive)=328.raw; RAW_FILE_NAME(Raw_file_name_negative)=N328.raw SUBJECT_SAMPLE_FACTORS DUMMY47 329 Sample source:Plasma | Group:A RAW_FILE_NAME(Raw_file_name_positive)=329.raw; RAW_FILE_NAME(Raw_file_name_negative)=N329.raw SUBJECT_SAMPLE_FACTORS DUMMY97 33 Sample source:Plasma | Group:A RAW_FILE_NAME(Raw_file_name_positive)=33.raw; RAW_FILE_NAME(Raw_file_name_negative)=N33.raw SUBJECT_SAMPLE_FACTORS DUMMY75 331 Sample source:Plasma | Group:A RAW_FILE_NAME(Raw_file_name_positive)=331.raw; RAW_FILE_NAME(Raw_file_name_negative)=N331.raw SUBJECT_SAMPLE_FACTORS DUMMY235 333 Sample source:Plasma | Group:A RAW_FILE_NAME(Raw_file_name_positive)=333.raw; RAW_FILE_NAME(Raw_file_name_negative)=N333.raw SUBJECT_SAMPLE_FACTORS DUMMY49 334 Sample source:Plasma | Group:A RAW_FILE_NAME(Raw_file_name_positive)=334.raw; RAW_FILE_NAME(Raw_file_name_negative)=N334.raw SUBJECT_SAMPLE_FACTORS DUMMY237 337 Sample source:Plasma | Group:A RAW_FILE_NAME(Raw_file_name_positive)=337.raw; RAW_FILE_NAME(Raw_file_name_negative)=N337.raw SUBJECT_SAMPLE_FACTORS DUMMY50 339 Sample source:Plasma | Group:A RAW_FILE_NAME(Raw_file_name_positive)=339.raw; RAW_FILE_NAME(Raw_file_name_negative)=N339.raw SUBJECT_SAMPLE_FACTORS DUMMY51 341 Sample source:Plasma | Group:A RAW_FILE_NAME(Raw_file_name_positive)=341.raw; RAW_FILE_NAME(Raw_file_name_negative)=N341.raw SUBJECT_SAMPLE_FACTORS DUMMY52 343 Sample source:Plasma | Group:A RAW_FILE_NAME(Raw_file_name_positive)=343.raw; RAW_FILE_NAME(Raw_file_name_negative)=N343.raw SUBJECT_SAMPLE_FACTORS DUMMY239 345 Sample source:Plasma | Group:A RAW_FILE_NAME(Raw_file_name_positive)=345.raw; RAW_FILE_NAME(Raw_file_name_negative)=N345.raw SUBJECT_SAMPLE_FACTORS DUMMY81 346 Sample source:Plasma | Group:A RAW_FILE_NAME(Raw_file_name_positive)=346.raw; RAW_FILE_NAME(Raw_file_name_negative)=N346.raw SUBJECT_SAMPLE_FACTORS DUMMY240 348 Sample source:Plasma | Group:A RAW_FILE_NAME(Raw_file_name_positive)=348.raw; RAW_FILE_NAME(Raw_file_name_negative)=N348.raw SUBJECT_SAMPLE_FACTORS DUMMY242 350 Sample source:Plasma | Group:A RAW_FILE_NAME(Raw_file_name_positive)=350.raw; RAW_FILE_NAME(Raw_file_name_negative)=N350.raw SUBJECT_SAMPLE_FACTORS DUMMY243 351 Sample source:Plasma | Group:A RAW_FILE_NAME(Raw_file_name_positive)=351.raw; RAW_FILE_NAME(Raw_file_name_negative)=N351.raw SUBJECT_SAMPLE_FACTORS DUMMY244 352 Sample source:Plasma | Group:A RAW_FILE_NAME(Raw_file_name_positive)=352.raw; RAW_FILE_NAME(Raw_file_name_negative)=N352.raw SUBJECT_SAMPLE_FACTORS DUMMY54 353 Sample source:Plasma | Group:A RAW_FILE_NAME(Raw_file_name_positive)=353.raw; RAW_FILE_NAME(Raw_file_name_negative)=N353.raw SUBJECT_SAMPLE_FACTORS DUMMY76 355 Sample source:Plasma | Group:A RAW_FILE_NAME(Raw_file_name_positive)=355.raw; RAW_FILE_NAME(Raw_file_name_negative)=N355.raw SUBJECT_SAMPLE_FACTORS DUMMY245 357 Sample source:Plasma | Group:A RAW_FILE_NAME(Raw_file_name_positive)=357.raw; RAW_FILE_NAME(Raw_file_name_negative)=N357.raw SUBJECT_SAMPLE_FACTORS DUMMY246 358 Sample source:Plasma | Group:A RAW_FILE_NAME(Raw_file_name_positive)=358.raw; RAW_FILE_NAME(Raw_file_name_negative)=N358.raw SUBJECT_SAMPLE_FACTORS DUMMY247 359 Sample source:Plasma | Group:A RAW_FILE_NAME(Raw_file_name_positive)=359.raw; RAW_FILE_NAME(Raw_file_name_negative)=N359.raw SUBJECT_SAMPLE_FACTORS DUMMY248 360 Sample source:Plasma | Group:A RAW_FILE_NAME(Raw_file_name_positive)=360.raw; RAW_FILE_NAME(Raw_file_name_negative)=N360.raw SUBJECT_SAMPLE_FACTORS DUMMY249 361 Sample source:Plasma | Group:A RAW_FILE_NAME(Raw_file_name_positive)=361.raw; RAW_FILE_NAME(Raw_file_name_negative)=N361.raw SUBJECT_SAMPLE_FACTORS DUMMY250 362 Sample source:Plasma | Group:A RAW_FILE_NAME(Raw_file_name_positive)=362.raw; RAW_FILE_NAME(Raw_file_name_negative)=N362.raw SUBJECT_SAMPLE_FACTORS DUMMY251 363 Sample source:Plasma | Group:A RAW_FILE_NAME(Raw_file_name_positive)=363.raw; RAW_FILE_NAME(Raw_file_name_negative)=N363.raw SUBJECT_SAMPLE_FACTORS DUMMY252 364 Sample source:Plasma | Group:A RAW_FILE_NAME(Raw_file_name_positive)=364.raw; RAW_FILE_NAME(Raw_file_name_negative)=N364.raw SUBJECT_SAMPLE_FACTORS DUMMY253 365 Sample source:Plasma | Group:A RAW_FILE_NAME(Raw_file_name_positive)=365.raw; RAW_FILE_NAME(Raw_file_name_negative)=N365.raw SUBJECT_SAMPLE_FACTORS DUMMY255 367 Sample source:Plasma | Group:A RAW_FILE_NAME(Raw_file_name_positive)=367.raw; RAW_FILE_NAME(Raw_file_name_negative)=N367.raw SUBJECT_SAMPLE_FACTORS DUMMY256 368 Sample source:Plasma | Group:A RAW_FILE_NAME(Raw_file_name_positive)=368.raw; RAW_FILE_NAME(Raw_file_name_negative)=N368.raw SUBJECT_SAMPLE_FACTORS DUMMY257 369 Sample source:Plasma | Group:A RAW_FILE_NAME(Raw_file_name_positive)=369.raw; RAW_FILE_NAME(Raw_file_name_negative)=N369.raw SUBJECT_SAMPLE_FACTORS DUMMY99 37 Sample source:Plasma | Group:A RAW_FILE_NAME(Raw_file_name_positive)=37.raw; RAW_FILE_NAME(Raw_file_name_negative)=N37.raw SUBJECT_SAMPLE_FACTORS DUMMY258 370 Sample source:Plasma | Group:A RAW_FILE_NAME(Raw_file_name_positive)=370.raw; RAW_FILE_NAME(Raw_file_name_negative)=N370.raw SUBJECT_SAMPLE_FACTORS DUMMY259 371 Sample source:Plasma | Group:A RAW_FILE_NAME(Raw_file_name_positive)=371.raw; RAW_FILE_NAME(Raw_file_name_negative)=N371.raw SUBJECT_SAMPLE_FACTORS DUMMY260 372 Sample source:Plasma | Group:A RAW_FILE_NAME(Raw_file_name_positive)=372.raw; RAW_FILE_NAME(Raw_file_name_negative)=N372.raw SUBJECT_SAMPLE_FACTORS DUMMY261 373 Sample source:Plasma | Group:A RAW_FILE_NAME(Raw_file_name_positive)=373.raw; RAW_FILE_NAME(Raw_file_name_negative)=N373.raw SUBJECT_SAMPLE_FACTORS DUMMY262 374 Sample source:Plasma | Group:A RAW_FILE_NAME(Raw_file_name_positive)=374.raw; RAW_FILE_NAME(Raw_file_name_negative)=N374.raw SUBJECT_SAMPLE_FACTORS DUMMY263 375 Sample source:Plasma | Group:A RAW_FILE_NAME(Raw_file_name_positive)=375.raw; RAW_FILE_NAME(Raw_file_name_negative)=N375.raw SUBJECT_SAMPLE_FACTORS DUMMY264 376 Sample source:Plasma | Group:A RAW_FILE_NAME(Raw_file_name_positive)=376.raw; RAW_FILE_NAME(Raw_file_name_negative)=N376.raw SUBJECT_SAMPLE_FACTORS DUMMY265 377 Sample source:Plasma | Group:A RAW_FILE_NAME(Raw_file_name_positive)=377.raw; RAW_FILE_NAME(Raw_file_name_negative)=N377.raw SUBJECT_SAMPLE_FACTORS DUMMY38 39 Sample source:Plasma | Group:A RAW_FILE_NAME(Raw_file_name_positive)=39.raw; RAW_FILE_NAME(Raw_file_name_negative)=N39.raw SUBJECT_SAMPLE_FACTORS DUMMY100 41 Sample source:Plasma | Group:A RAW_FILE_NAME(Raw_file_name_positive)=41.raw; RAW_FILE_NAME(Raw_file_name_negative)=N41.raw SUBJECT_SAMPLE_FACTORS DUMMY101 43 Sample source:Plasma | Group:A RAW_FILE_NAME(Raw_file_name_positive)=43.raw; RAW_FILE_NAME(Raw_file_name_negative)=N43.raw SUBJECT_SAMPLE_FACTORS DUMMY102 45 Sample source:Plasma | Group:A RAW_FILE_NAME(Raw_file_name_positive)=45.raw; RAW_FILE_NAME(Raw_file_name_negative)=N45.raw SUBJECT_SAMPLE_FACTORS DUMMY115 47 Sample source:Plasma | Group:A RAW_FILE_NAME(Raw_file_name_positive)=47.raw; RAW_FILE_NAME(Raw_file_name_negative)=N47.raw SUBJECT_SAMPLE_FACTORS DUMMY103 48 Sample source:Plasma | Group:A RAW_FILE_NAME(Raw_file_name_positive)=48.raw; RAW_FILE_NAME(Raw_file_name_negative)=N48.raw SUBJECT_SAMPLE_FACTORS DUMMY84 5 Sample source:Plasma | Group:A RAW_FILE_NAME(Raw_file_name_positive)=5.raw; RAW_FILE_NAME(Raw_file_name_negative)=N5.raw SUBJECT_SAMPLE_FACTORS DUMMY116 50 Sample source:Plasma | Group:A RAW_FILE_NAME(Raw_file_name_positive)=50.raw; RAW_FILE_NAME(Raw_file_name_negative)=N50.raw SUBJECT_SAMPLE_FACTORS DUMMY104 51 Sample source:Plasma | Group:A RAW_FILE_NAME(Raw_file_name_positive)=51.raw; RAW_FILE_NAME(Raw_file_name_negative)=N51.raw SUBJECT_SAMPLE_FACTORS DUMMY105 53 Sample source:Plasma | Group:A RAW_FILE_NAME(Raw_file_name_positive)=53.raw; RAW_FILE_NAME(Raw_file_name_negative)=N53.raw SUBJECT_SAMPLE_FACTORS DUMMY106 55 Sample source:Plasma | Group:A RAW_FILE_NAME(Raw_file_name_positive)=55.raw; RAW_FILE_NAME(Raw_file_name_negative)=N55.raw SUBJECT_SAMPLE_FACTORS DUMMY107 57 Sample source:Plasma | Group:A RAW_FILE_NAME(Raw_file_name_positive)=57.raw; RAW_FILE_NAME(Raw_file_name_negative)=N57.raw SUBJECT_SAMPLE_FACTORS DUMMY108 59 Sample source:Plasma | Group:A RAW_FILE_NAME(Raw_file_name_positive)=59.raw; RAW_FILE_NAME(Raw_file_name_negative)=N59.raw SUBJECT_SAMPLE_FACTORS DUMMY117 61 Sample source:Plasma | Group:A RAW_FILE_NAME(Raw_file_name_positive)=61.raw; RAW_FILE_NAME(Raw_file_name_negative)=N61.raw SUBJECT_SAMPLE_FACTORS DUMMY109 62 Sample source:Plasma | Group:A RAW_FILE_NAME(Raw_file_name_positive)=62.raw; RAW_FILE_NAME(Raw_file_name_negative)=N62.raw SUBJECT_SAMPLE_FACTORS DUMMY110 64 Sample source:Plasma | Group:A RAW_FILE_NAME(Raw_file_name_positive)=64.raw; RAW_FILE_NAME(Raw_file_name_negative)=N64.raw SUBJECT_SAMPLE_FACTORS DUMMY111 66 Sample source:Plasma | Group:A RAW_FILE_NAME(Raw_file_name_positive)=66.raw; RAW_FILE_NAME(Raw_file_name_negative)=N66.raw SUBJECT_SAMPLE_FACTORS DUMMY118 68 Sample source:Plasma | Group:A RAW_FILE_NAME(Raw_file_name_positive)=68.raw; RAW_FILE_NAME(Raw_file_name_negative)=N68.raw SUBJECT_SAMPLE_FACTORS DUMMY119 69 Sample source:Plasma | Group:A RAW_FILE_NAME(Raw_file_name_positive)=69.raw; RAW_FILE_NAME(Raw_file_name_negative)=N69.raw SUBJECT_SAMPLE_FACTORS DUMMY85 7 Sample source:Plasma | Group:A RAW_FILE_NAME(Raw_file_name_positive)=7.raw; RAW_FILE_NAME(Raw_file_name_negative)=N7.raw SUBJECT_SAMPLE_FACTORS DUMMY120 70 Sample source:Plasma | Group:A RAW_FILE_NAME(Raw_file_name_positive)=70.raw; RAW_FILE_NAME(Raw_file_name_negative)=N70.raw SUBJECT_SAMPLE_FACTORS DUMMY121 71 Sample source:Plasma | Group:A RAW_FILE_NAME(Raw_file_name_positive)=71.raw; RAW_FILE_NAME(Raw_file_name_negative)=N71.raw SUBJECT_SAMPLE_FACTORS DUMMY122 72 Sample source:Plasma | Group:A RAW_FILE_NAME(Raw_file_name_positive)=72.raw; RAW_FILE_NAME(Raw_file_name_negative)=N72.raw SUBJECT_SAMPLE_FACTORS DUMMY123 73 Sample source:Plasma | Group:A RAW_FILE_NAME(Raw_file_name_positive)=73.raw; RAW_FILE_NAME(Raw_file_name_negative)=N73.raw SUBJECT_SAMPLE_FACTORS DUMMY124 74 Sample source:Plasma | Group:A RAW_FILE_NAME(Raw_file_name_positive)=74.raw; RAW_FILE_NAME(Raw_file_name_negative)=N74.raw SUBJECT_SAMPLE_FACTORS DUMMY126 76 Sample source:Plasma | Group:A RAW_FILE_NAME(Raw_file_name_positive)=76.raw; RAW_FILE_NAME(Raw_file_name_negative)=N76.raw SUBJECT_SAMPLE_FACTORS DUMMY127 77 Sample source:Plasma | Group:A RAW_FILE_NAME(Raw_file_name_positive)=77.raw; RAW_FILE_NAME(Raw_file_name_negative)=N77.raw SUBJECT_SAMPLE_FACTORS DUMMY130 80 Sample source:Plasma | Group:A RAW_FILE_NAME(Raw_file_name_positive)=80.raw; RAW_FILE_NAME(Raw_file_name_negative)=N80.raw SUBJECT_SAMPLE_FACTORS DUMMY131 81 Sample source:Plasma | Group:A RAW_FILE_NAME(Raw_file_name_positive)=81.raw; RAW_FILE_NAME(Raw_file_name_negative)=N81.raw SUBJECT_SAMPLE_FACTORS DUMMY132 82 Sample source:Plasma | Group:A RAW_FILE_NAME(Raw_file_name_positive)=82.raw; RAW_FILE_NAME(Raw_file_name_negative)=N82.raw SUBJECT_SAMPLE_FACTORS DUMMY133 83 Sample source:Plasma | Group:A RAW_FILE_NAME(Raw_file_name_positive)=83.raw; RAW_FILE_NAME(Raw_file_name_negative)=N83.raw SUBJECT_SAMPLE_FACTORS DUMMY134 84 Sample source:Plasma | Group:A RAW_FILE_NAME(Raw_file_name_positive)=84.raw; RAW_FILE_NAME(Raw_file_name_negative)=N84.raw SUBJECT_SAMPLE_FACTORS DUMMY135 85 Sample source:Plasma | Group:A RAW_FILE_NAME(Raw_file_name_positive)=85.raw; RAW_FILE_NAME(Raw_file_name_negative)=N85.raw SUBJECT_SAMPLE_FACTORS DUMMY18 86 Sample source:Plasma | Group:A RAW_FILE_NAME(Raw_file_name_positive)=86.raw; RAW_FILE_NAME(Raw_file_name_negative)=N86.raw SUBJECT_SAMPLE_FACTORS DUMMY136 88 Sample source:Plasma | Group:A RAW_FILE_NAME(Raw_file_name_positive)=88.raw; RAW_FILE_NAME(Raw_file_name_negative)=N88.raw SUBJECT_SAMPLE_FACTORS DUMMY137 89 Sample source:Plasma | Group:A RAW_FILE_NAME(Raw_file_name_positive)=89.raw; RAW_FILE_NAME(Raw_file_name_negative)=N89.raw SUBJECT_SAMPLE_FACTORS DUMMY86 9 Sample source:Plasma | Group:A RAW_FILE_NAME(Raw_file_name_positive)=9.raw; RAW_FILE_NAME(Raw_file_name_negative)=N9.raw SUBJECT_SAMPLE_FACTORS DUMMY138 90 Sample source:Plasma | Group:A RAW_FILE_NAME(Raw_file_name_positive)=90.raw; RAW_FILE_NAME(Raw_file_name_negative)=N90.raw SUBJECT_SAMPLE_FACTORS DUMMY139 91 Sample source:Plasma | Group:A RAW_FILE_NAME(Raw_file_name_positive)=91.raw; RAW_FILE_NAME(Raw_file_name_negative)=N91.raw SUBJECT_SAMPLE_FACTORS DUMMY140 92 Sample source:Plasma | Group:A RAW_FILE_NAME(Raw_file_name_positive)=92.raw; RAW_FILE_NAME(Raw_file_name_negative)=N92.raw SUBJECT_SAMPLE_FACTORS DUMMY141 93 Sample source:Plasma | Group:A RAW_FILE_NAME(Raw_file_name_positive)=93.raw; RAW_FILE_NAME(Raw_file_name_negative)=N93.raw SUBJECT_SAMPLE_FACTORS DUMMY19 94 Sample source:Plasma | Group:A RAW_FILE_NAME(Raw_file_name_positive)=94.raw; RAW_FILE_NAME(Raw_file_name_negative)=N94.raw SUBJECT_SAMPLE_FACTORS DUMMY142 96 Sample source:Plasma | Group:A RAW_FILE_NAME(Raw_file_name_positive)=96.raw; RAW_FILE_NAME(Raw_file_name_negative)=N96.raw SUBJECT_SAMPLE_FACTORS DUMMY143 97 Sample source:Plasma | Group:A RAW_FILE_NAME(Raw_file_name_positive)=97.raw; RAW_FILE_NAME(Raw_file_name_negative)=N97.raw SUBJECT_SAMPLE_FACTORS DUMMY67 99 Sample source:Plasma | Group:A RAW_FILE_NAME(Raw_file_name_positive)=99.raw; RAW_FILE_NAME(Raw_file_name_negative)=N99.raw #COLLECTION CO:COLLECTION_SUMMARY Plasma samples obtained from participants during their first Multicenter AIDS CO:COLLECTION_SUMMARY Cohort Study (MACS) clinic visit and stored at -80 ° C (Wade et al 2015, AIDS. CO:SAMPLE_TYPE Blood (plasma) #TREATMENT TR:TREATMENT_SUMMARY This study includes Men who have Sex with Men (MSM) enrolled in the Multicenter TR:TREATMENT_SUMMARY AIDS Cohort study (MACS). All participants were HIV-1-negative during their TR:TREATMENT_SUMMARY first MACS clinic visit when samples were collected. This study compares gut, TR:TREATMENT_SUMMARY plasma, and oral metabolic profiles between those who became infected with HIV-1 TR:TREATMENT_SUMMARY by their second study clinic visit approximately 6 months later (termed Pre-HIV) TR:TREATMENT_SUMMARY and those who remained HIV-negative (termed Non-HIV) at their second MACS clinic TR:TREATMENT_SUMMARY visit. #SAMPLEPREP SP:SAMPLEPREP_SUMMARY Sample were thawed on ice and transfer 100 μL sample into tube, added with 300 SP:SAMPLEPREP_SUMMARY μL methanol. All samples were vortexed 30 s, and followed by sonication for 30 SP:SAMPLEPREP_SUMMARY min, 4°C. Then each sample was kept at -20°C for 1 h, vortexed for 30 s and SP:SAMPLEPREP_SUMMARY kept at 4°C for 30 min. After that, samples were centrifuged at 12,000 rpm and SP:SAMPLEPREP_SUMMARY 4°C for 15 min. All the supernatant was transferred to a new tube, keep at SP:SAMPLEPREP_SUMMARY -20°C for 1 h, centrifuged at 12,000 rpm and 4°C for 15 min. Finally, 200 μL SP:SAMPLEPREP_SUMMARY of supernatant into vial and and 5 μL of 0.14 mg/mL DL-o-Chlorophenylalanine as SP:SAMPLEPREP_SUMMARY internal standard, filtered through a 0.22 μm filter for LC-MS analysis. SP:SAMPLEPREP_PROTOCOL_FILENAME Untargeted_Metabolomics_Analysis_Report_Creative_Proteomics_CPLC02082301_370_Plasma.pdf #CHROMATOGRAPHY CH:INSTRUMENT_NAME Waters ACQUITY CH:COLUMN_NAME ACQUITY UPLC HSS T3 (100 x 2.1 mm, 1.8 μm) CH:COLUMN_TEMPERATURE 40°C CH:FLOW_GRADIENT 0-1.0 min, 5% B; 1.0-12.5 min, 5%-95% B; 12.5-13.5 min, 95% B; 13.5-13.6 min, CH:FLOW_GRADIENT 95%-5% B; 13.6-16 min, 5% B CH:FLOW_RATE 0.3 mL/min CH:SOLVENT_A 100% Water; 0.05% Formic acid CH:SOLVENT_B 100% Acetonitrile CH:CHROMATOGRAPHY_TYPE Reversed phase #ANALYSIS AN:ANALYSIS_TYPE MS #MS MS:INSTRUMENT_NAME Thermo Q Exactive Focus MS:INSTRUMENT_TYPE Orbitrap MS:MS_TYPE ESI MS:MS_COMMENTS The electrospray ionization positive mode was operated using following MS:MS_COMMENTS conditions: heater temperature of 300°C, sheath gas flow rate of 45 arb, aux MS:MS_COMMENTS gas flow rate of 15 arb, sweep gas flow rate of 1 arb, spray voltage of 3.0 KV, MS:MS_COMMENTS capillary temperature of 350°C and S-Lens RF level set constant at 30%.The full MS:MS_COMMENTS scan was performed 70-1050 m/z at the resolution of 70,000 fwhm, automatic gain MS:MS_COMMENTS control (AGC) target of 3×106, maximum injection time of 100 ms and spectrum MS:MS_COMMENTS data type of centroid. Significant features were identified using data-dependent MS:MS_COMMENTS MS2. Settings for dd-MS2 data acquisition was as follows, resolution of 17,500 MS:MS_COMMENTS fwhm, AGC target of 1×105, maximum injection time of 50 ms, isolation window of MS:MS_COMMENTS 1.7 m/z, loop count of 10, and normalized collision energy (NCE) was set at 15, MS:MS_COMMENTS 30 and 45 eV, spectrum data type of centroid. The Compound Discoverer 3.1 MS:MS_COMMENTS (CD3.1, Thermo Fisher) software was used to process raw data generated by the MS:MS_COMMENTS UPLC-MS via peak alignment, peak picking, and identification of each metabolite. MS:MS_COMMENTS After analysis, these data were matched with the mzCloud, mzVault databases to MS:MS_COMMENTS obtain accurate identification results. The data was further processed by MS:MS_COMMENTS Progenesis QI to provide strong support for identifying metabolites accurately. MS:ION_MODE POSITIVE MS:MS_RESULTS_FILE ST004208_AN006998_Results.txt UNITS:Peak area Has m/z:Yes Has RT:Yes RT units:Minutes #END