#METABOLOMICS WORKBENCH ffouladi_20250917_064837 DATATRACK_ID:6441 STUDY_ID:ST004209 ANALYSIS_ID:AN007001 PROJECT_ID:PR002653 VERSION 1 CREATED_ON September 22, 2025, 6:04 pm #PROJECT PR:PROJECT_TITLE A taxon-specific measurement of disruption in a multi-modal study of microbiomes PR:PROJECT_TITLE and metabolomes reveals system-wide dysbiosis preceding HIV-1 infection PR:PROJECT_SUMMARY The microbiome is important in immune responses and inflammation in HIV-1 PR:PROJECT_SUMMARY infection. Hence, a deeper understanding of the microbiome prior to HIV-1 PR:PROJECT_SUMMARY infection is potentially important for HIV-1 prevention strategies. Using stool, PR:PROJECT_SUMMARY oral washes, and plasma biospecimens obtained from HIV-1 negative men who have PR:PROJECT_SUMMARY sex with men (MSM), we found several differences in microbial ecologies, gene PR:PROJECT_SUMMARY functions, and metabolites between MSM who became HIV-1 infected approximately 6 PR:PROJECT_SUMMARY months later and those who remained HIV-1 uninfected. The HIV-1 infected MSM had PR:PROJECT_SUMMARY an enrichment of enzymes involved in purine metabolism, lower amino acid PR:PROJECT_SUMMARY metabolism, and higher oxidative stress before the infection. Using a novel PR:PROJECT_SUMMARY taxon-specific measure of DISruption in COrrelations (DISCO) with various data PR:PROJECT_SUMMARY modalities, we identified several gut and oral species with disrupted PR:PROJECT_SUMMARY correlations prior to HIV-1 infection. Application of DISCO to external datasets PR:PROJECT_SUMMARY revealed that Prevotella spp. are consistently disrupted in their correlations PR:PROJECT_SUMMARY across multiple cohorts prior to or following HIV-1 infection. PR:INSTITUTE National Institute of Environmental Health Sciences PR:LAST_NAME Fouladi PR:FIRST_NAME Farnaz PR:ADDRESS 111 T.W. Alexander Drive, Durham, NC 27709 PR:EMAIL farnaz.fouladi@nih.gov PR:PHONE 984-287-4663 #STUDY ST:STUDY_TITLE Oral Metabolomics Profiling in Men Who Have Sex with Men Before HIV-1 Infection ST:STUDY_SUMMARY This study includes Men who have Sex with Men (MSM) enrolled in the Multicenter ST:STUDY_SUMMARY AIDS Cohort study (MACS) between 1984-1985. All participants were HIV-1-negative ST:STUDY_SUMMARY during their first MACS clinic visit, when samples were collected. Metabolic ST:STUDY_SUMMARY profiles are compared between those who were infected with HIV-1 by their second ST:STUDY_SUMMARY study clinic visit approximately 6 months later (termed Pre-HIV) and those who ST:STUDY_SUMMARY remained HIV-negative (termed Non-HIV) at their second MACS clinic visit. Data ST:STUDY_SUMMARY Availability: Access to individual-level data from the MACS/WIHS Combined Cohort ST:STUDY_SUMMARY Study Data (MWCCS) may be obtained upon review and approval of a MWCCS concept ST:STUDY_SUMMARY sheet. Links and instructions for online concept sheet submission are on the ST:STUDY_SUMMARY study website (http://mwccs.org/). Once the concept sheet is approved, please ST:STUDY_SUMMARY contact Dr. Yue Chen (cheny@pitt.edu) to obtain the metadata. ST:INSTITUTE National Institute of Environmental Health Sciences ST:LAST_NAME Fouladi ST:FIRST_NAME Farnaz ST:ADDRESS 111 T.W. Alexander Drive, Durham, NC 27709 ST:EMAIL farnaz.fouladi@nih.gov ST:PHONE 984-287-4663 #SUBJECT SU:SUBJECT_TYPE Human SU:SUBJECT_SPECIES Homo sapiens SU:TAXONOMY_ID 9606 #SUBJECT_SAMPLE_FACTORS: SUBJECT(optional)[tab]SAMPLE[tab]FACTORS(NAME:VALUE pairs separated by |)[tab]Raw file names and additional sample data SUBJECT_SAMPLE_FACTORS DUMMY82 1 Sample source:Oral wash | Group:A RAW_FILE_NAME(Raw_file_name_positive)=O1.raw; RAW_FILE_NAME(Raw_file_name_negative)=ON1.raw SUBJECT_SAMPLE_FACTORS DUMMY83 3 Sample source:Oral wash | Group:A RAW_FILE_NAME(Raw_file_name_positive)=O3.raw; RAW_FILE_NAME(Raw_file_name_negative)=ON3.raw SUBJECT_SAMPLE_FACTORS DUMMY84 5 Sample source:Oral wash | Group:A RAW_FILE_NAME(Raw_file_name_positive)=O5.raw; RAW_FILE_NAME(Raw_file_name_negative)=ON5.raw SUBJECT_SAMPLE_FACTORS DUMMY85 7 Sample source:Oral wash | Group:A RAW_FILE_NAME(Raw_file_name_positive)=O7.raw; RAW_FILE_NAME(Raw_file_name_negative)=ON7.raw SUBJECT_SAMPLE_FACTORS DUMMY86 9 Sample source:Oral wash | Group:A RAW_FILE_NAME(Raw_file_name_positive)=O9.raw; RAW_FILE_NAME(Raw_file_name_negative)=ON9.raw SUBJECT_SAMPLE_FACTORS DUMMY87 11 Sample source:Oral wash | Group:A RAW_FILE_NAME(Raw_file_name_positive)=O11.raw; RAW_FILE_NAME(Raw_file_name_negative)=ON11.raw SUBJECT_SAMPLE_FACTORS DUMMY113 13 Sample source:Oral wash | Group:A RAW_FILE_NAME(Raw_file_name_positive)=O13.raw; RAW_FILE_NAME(Raw_file_name_negative)=ON13.raw SUBJECT_SAMPLE_FACTORS DUMMY88 14 Sample source:Oral wash | Group:A RAW_FILE_NAME(Raw_file_name_positive)=O14.raw; RAW_FILE_NAME(Raw_file_name_negative)=ON14.raw SUBJECT_SAMPLE_FACTORS DUMMY89 16 Sample source:Oral wash | Group:A RAW_FILE_NAME(Raw_file_name_positive)=O16.raw; RAW_FILE_NAME(Raw_file_name_negative)=ON16.raw SUBJECT_SAMPLE_FACTORS DUMMY114 18 Sample source:Oral wash | Group:A RAW_FILE_NAME(Raw_file_name_positive)=O18.raw; RAW_FILE_NAME(Raw_file_name_negative)=ON18.raw SUBJECT_SAMPLE_FACTORS DUMMY90 19 Sample source:Oral wash | Group:A RAW_FILE_NAME(Raw_file_name_positive)=O19.raw; RAW_FILE_NAME(Raw_file_name_negative)=ON19.raw SUBJECT_SAMPLE_FACTORS DUMMY91 21 Sample source:Oral wash | Group:A RAW_FILE_NAME(Raw_file_name_positive)=O21.raw; RAW_FILE_NAME(Raw_file_name_negative)=ON21.raw SUBJECT_SAMPLE_FACTORS DUMMY92 23 Sample source:Oral wash | Group:A RAW_FILE_NAME(Raw_file_name_positive)=O23.raw; RAW_FILE_NAME(Raw_file_name_negative)=ON23.raw SUBJECT_SAMPLE_FACTORS DUMMY93 25 Sample source:Oral wash | Group:A RAW_FILE_NAME(Raw_file_name_positive)=O25.raw; RAW_FILE_NAME(Raw_file_name_negative)=ON25.raw SUBJECT_SAMPLE_FACTORS DUMMY94 27 Sample source:Oral wash | Group:A RAW_FILE_NAME(Raw_file_name_positive)=O27.raw; RAW_FILE_NAME(Raw_file_name_negative)=ON27.raw SUBJECT_SAMPLE_FACTORS DUMMY95 29 Sample source:Oral wash | Group:A RAW_FILE_NAME(Raw_file_name_positive)=O29.raw; RAW_FILE_NAME(Raw_file_name_negative)=ON29.raw SUBJECT_SAMPLE_FACTORS DUMMY96 31 Sample source:Oral wash | Group:A RAW_FILE_NAME(Raw_file_name_positive)=O31.raw; RAW_FILE_NAME(Raw_file_name_negative)=ON31.raw SUBJECT_SAMPLE_FACTORS DUMMY97 33 Sample source:Oral wash | Group:A RAW_FILE_NAME(Raw_file_name_positive)=O33.raw; RAW_FILE_NAME(Raw_file_name_negative)=ON33.raw SUBJECT_SAMPLE_FACTORS DUMMY99 37 Sample source:Oral wash | Group:A RAW_FILE_NAME(Raw_file_name_positive)=O37.raw; RAW_FILE_NAME(Raw_file_name_negative)=ON37.raw SUBJECT_SAMPLE_FACTORS DUMMY100 41 Sample source:Oral wash | Group:A RAW_FILE_NAME(Raw_file_name_positive)=O41.raw; RAW_FILE_NAME(Raw_file_name_negative)=ON41.raw SUBJECT_SAMPLE_FACTORS DUMMY101 43 Sample source:Oral wash | Group:A RAW_FILE_NAME(Raw_file_name_positive)=O43.raw; RAW_FILE_NAME(Raw_file_name_negative)=ON43.raw SUBJECT_SAMPLE_FACTORS DUMMY102 45 Sample source:Oral wash | Group:A RAW_FILE_NAME(Raw_file_name_positive)=O45.raw; RAW_FILE_NAME(Raw_file_name_negative)=ON45.raw SUBJECT_SAMPLE_FACTORS DUMMY115 47 Sample source:Oral wash | Group:A RAW_FILE_NAME(Raw_file_name_positive)=O47.raw; RAW_FILE_NAME(Raw_file_name_negative)=ON47.raw SUBJECT_SAMPLE_FACTORS DUMMY103 48 Sample source:Oral wash | Group:A RAW_FILE_NAME(Raw_file_name_positive)=O48.raw; RAW_FILE_NAME(Raw_file_name_negative)=ON48.raw SUBJECT_SAMPLE_FACTORS DUMMY104 51 Sample source:Oral wash | Group:A RAW_FILE_NAME(Raw_file_name_positive)=O51.raw; RAW_FILE_NAME(Raw_file_name_negative)=ON51.raw SUBJECT_SAMPLE_FACTORS DUMMY105 53 Sample source:Oral wash | Group:A RAW_FILE_NAME(Raw_file_name_positive)=O53.raw; RAW_FILE_NAME(Raw_file_name_negative)=ON53.raw SUBJECT_SAMPLE_FACTORS DUMMY106 55 Sample source:Oral wash | Group:A RAW_FILE_NAME(Raw_file_name_positive)=O55.raw; RAW_FILE_NAME(Raw_file_name_negative)=ON55.raw SUBJECT_SAMPLE_FACTORS DUMMY107 57 Sample source:Oral wash | Group:A RAW_FILE_NAME(Raw_file_name_positive)=O57.raw; RAW_FILE_NAME(Raw_file_name_negative)=ON57.raw SUBJECT_SAMPLE_FACTORS DUMMY108 59 Sample source:Oral wash | Group:A RAW_FILE_NAME(Raw_file_name_positive)=O59.raw; RAW_FILE_NAME(Raw_file_name_negative)=ON59.raw SUBJECT_SAMPLE_FACTORS DUMMY117 61 Sample source:Oral wash | Group:A RAW_FILE_NAME(Raw_file_name_positive)=O61.raw; RAW_FILE_NAME(Raw_file_name_negative)=ON61.raw SUBJECT_SAMPLE_FACTORS DUMMY109 62 Sample source:Oral wash | Group:A RAW_FILE_NAME(Raw_file_name_positive)=O62.raw; RAW_FILE_NAME(Raw_file_name_negative)=ON62.raw SUBJECT_SAMPLE_FACTORS DUMMY110 64 Sample source:Oral wash | Group:A RAW_FILE_NAME(Raw_file_name_positive)=O64.raw; RAW_FILE_NAME(Raw_file_name_negative)=ON64.raw SUBJECT_SAMPLE_FACTORS DUMMY111 66 Sample source:Oral wash | Group:A RAW_FILE_NAME(Raw_file_name_positive)=O66.raw; RAW_FILE_NAME(Raw_file_name_negative)=ON66.raw SUBJECT_SAMPLE_FACTORS DUMMY118 68 Sample source:Oral wash | Group:A RAW_FILE_NAME(Raw_file_name_positive)=O68.raw; RAW_FILE_NAME(Raw_file_name_negative)=ON68.raw SUBJECT_SAMPLE_FACTORS DUMMY119 69 Sample source:Oral wash | Group:A RAW_FILE_NAME(Raw_file_name_positive)=O69.raw; RAW_FILE_NAME(Raw_file_name_negative)=ON69.raw SUBJECT_SAMPLE_FACTORS DUMMY121 71 Sample source:Oral wash | Group:A RAW_FILE_NAME(Raw_file_name_positive)=O71.raw; RAW_FILE_NAME(Raw_file_name_negative)=ON71.raw SUBJECT_SAMPLE_FACTORS DUMMY122 72 Sample source:Oral wash | Group:A RAW_FILE_NAME(Raw_file_name_positive)=O72.raw; RAW_FILE_NAME(Raw_file_name_negative)=ON72.raw SUBJECT_SAMPLE_FACTORS DUMMY123 73 Sample source:Oral wash | Group:A RAW_FILE_NAME(Raw_file_name_positive)=O73.raw; RAW_FILE_NAME(Raw_file_name_negative)=ON73.raw SUBJECT_SAMPLE_FACTORS DUMMY126 76 Sample source:Oral wash | Group:A RAW_FILE_NAME(Raw_file_name_positive)=O76.raw; RAW_FILE_NAME(Raw_file_name_negative)=ON76.raw SUBJECT_SAMPLE_FACTORS DUMMY131 81 Sample source:Oral wash | Group:A RAW_FILE_NAME(Raw_file_name_positive)=O81.raw; RAW_FILE_NAME(Raw_file_name_negative)=ON81.raw SUBJECT_SAMPLE_FACTORS DUMMY134 84 Sample source:Oral wash | Group:A RAW_FILE_NAME(Raw_file_name_positive)=O84.raw; RAW_FILE_NAME(Raw_file_name_negative)=ON84.raw SUBJECT_SAMPLE_FACTORS DUMMY135 85 Sample source:Oral wash | Group:A RAW_FILE_NAME(Raw_file_name_positive)=O85.raw; RAW_FILE_NAME(Raw_file_name_negative)=ON85.raw SUBJECT_SAMPLE_FACTORS DUMMY137 89 Sample source:Oral wash | Group:A RAW_FILE_NAME(Raw_file_name_positive)=O89.raw; RAW_FILE_NAME(Raw_file_name_negative)=ON89.raw SUBJECT_SAMPLE_FACTORS DUMMY138 90 Sample source:Oral wash | Group:A RAW_FILE_NAME(Raw_file_name_positive)=O90.raw; RAW_FILE_NAME(Raw_file_name_negative)=ON90.raw SUBJECT_SAMPLE_FACTORS DUMMY139 91 Sample source:Oral wash | Group:A RAW_FILE_NAME(Raw_file_name_positive)=O91.raw; RAW_FILE_NAME(Raw_file_name_negative)=ON91.raw SUBJECT_SAMPLE_FACTORS DUMMY142 96 Sample source:Oral wash | Group:A RAW_FILE_NAME(Raw_file_name_positive)=O96.raw; RAW_FILE_NAME(Raw_file_name_negative)=ON96.raw SUBJECT_SAMPLE_FACTORS DUMMY143 97 Sample source:Oral wash | Group:A RAW_FILE_NAME(Raw_file_name_positive)=O97.raw; RAW_FILE_NAME(Raw_file_name_negative)=ON97.raw SUBJECT_SAMPLE_FACTORS DUMMY149 111 Sample source:Oral wash | Group:A RAW_FILE_NAME(Raw_file_name_positive)=O111.raw; RAW_FILE_NAME(Raw_file_name_negative)=ON111.raw SUBJECT_SAMPLE_FACTORS DUMMY39 112 Sample source:Oral wash | Group:A RAW_FILE_NAME(Raw_file_name_positive)=O112.raw; RAW_FILE_NAME(Raw_file_name_negative)=ON112.raw SUBJECT_SAMPLE_FACTORS DUMMY151 115 Sample source:Oral wash | Group:A RAW_FILE_NAME(Raw_file_name_positive)=O115.raw; RAW_FILE_NAME(Raw_file_name_negative)=ON115.raw SUBJECT_SAMPLE_FACTORS DUMMY35 116 Sample source:Oral wash | Group:A RAW_FILE_NAME(Raw_file_name_positive)=O116.raw; RAW_FILE_NAME(Raw_file_name_negative)=ON116.raw SUBJECT_SAMPLE_FACTORS DUMMY152 122 Sample source:Oral wash | Group:A RAW_FILE_NAME(Raw_file_name_positive)=O122.raw; RAW_FILE_NAME(Raw_file_name_negative)=ON122.raw SUBJECT_SAMPLE_FACTORS DUMMY36 123 Sample source:Oral wash | Group:A RAW_FILE_NAME(Raw_file_name_positive)=O123.raw; RAW_FILE_NAME(Raw_file_name_negative)=ON123.raw SUBJECT_SAMPLE_FACTORS DUMMY155 131 Sample source:Oral wash | Group:A RAW_FILE_NAME(Raw_file_name_positive)=O131.raw; RAW_FILE_NAME(Raw_file_name_negative)=ON131.raw SUBJECT_SAMPLE_FACTORS DUMMY156 132 Sample source:Oral wash | Group:A RAW_FILE_NAME(Raw_file_name_positive)=O132.raw; RAW_FILE_NAME(Raw_file_name_negative)=ON132.raw SUBJECT_SAMPLE_FACTORS DUMMY55 133 Sample source:Oral wash | Group:A RAW_FILE_NAME(Raw_file_name_positive)=O133.raw; RAW_FILE_NAME(Raw_file_name_negative)=ON133.raw SUBJECT_SAMPLE_FACTORS DUMMY56 136 Sample source:Oral wash | Group:A RAW_FILE_NAME(Raw_file_name_positive)=O136.raw; RAW_FILE_NAME(Raw_file_name_negative)=ON136.raw SUBJECT_SAMPLE_FACTORS DUMMY44 138 Sample source:Oral wash | Group:A RAW_FILE_NAME(Raw_file_name_positive)=O138.raw; RAW_FILE_NAME(Raw_file_name_negative)=ON138.raw SUBJECT_SAMPLE_FACTORS DUMMY57 140 Sample source:Oral wash | Group:A RAW_FILE_NAME(Raw_file_name_positive)=O140.raw; RAW_FILE_NAME(Raw_file_name_negative)=ON140.raw SUBJECT_SAMPLE_FACTORS DUMMY159 143 Sample source:Oral wash | Group:A RAW_FILE_NAME(Raw_file_name_positive)=O143.raw; RAW_FILE_NAME(Raw_file_name_negative)=ON143.raw SUBJECT_SAMPLE_FACTORS DUMMY160 144 Sample source:Oral wash | Group:A RAW_FILE_NAME(Raw_file_name_positive)=O144.raw; RAW_FILE_NAME(Raw_file_name_negative)=ON144.raw SUBJECT_SAMPLE_FACTORS DUMMY162 146 Sample source:Oral wash | Group:A RAW_FILE_NAME(Raw_file_name_positive)=O146.raw; RAW_FILE_NAME(Raw_file_name_negative)=ON146.raw SUBJECT_SAMPLE_FACTORS DUMMY58 149 Sample source:Oral wash | Group:A RAW_FILE_NAME(Raw_file_name_positive)=O149.raw; RAW_FILE_NAME(Raw_file_name_negative)=ON149.raw SUBJECT_SAMPLE_FACTORS DUMMY59 151 Sample source:Oral wash | Group:A RAW_FILE_NAME(Raw_file_name_positive)=O151.raw; RAW_FILE_NAME(Raw_file_name_negative)=ON151.raw SUBJECT_SAMPLE_FACTORS DUMMY31 157 Sample source:Oral wash | Group:A RAW_FILE_NAME(Raw_file_name_positive)=O157.raw; RAW_FILE_NAME(Raw_file_name_negative)=ON157.raw SUBJECT_SAMPLE_FACTORS DUMMY165 159 Sample source:Oral wash | Group:A RAW_FILE_NAME(Raw_file_name_positive)=O159.raw; RAW_FILE_NAME(Raw_file_name_negative)=ON159.raw SUBJECT_SAMPLE_FACTORS DUMMY166 160 Sample source:Oral wash | Group:A RAW_FILE_NAME(Raw_file_name_positive)=O160.raw; RAW_FILE_NAME(Raw_file_name_negative)=ON160.raw SUBJECT_SAMPLE_FACTORS DUMMY34 161 Sample source:Oral wash | Group:A RAW_FILE_NAME(Raw_file_name_positive)=O161.raw; RAW_FILE_NAME(Raw_file_name_negative)=ON161.raw SUBJECT_SAMPLE_FACTORS DUMMY1 166 Sample source:Oral wash | Group:A RAW_FILE_NAME(Raw_file_name_positive)=O166.raw; RAW_FILE_NAME(Raw_file_name_negative)=ON166.raw SUBJECT_SAMPLE_FACTORS DUMMY171 169 Sample source:Oral wash | Group:A RAW_FILE_NAME(Raw_file_name_positive)=O169.raw; RAW_FILE_NAME(Raw_file_name_negative)=ON169.raw SUBJECT_SAMPLE_FACTORS DUMMY2 170 Sample source:Oral wash | Group:A RAW_FILE_NAME(Raw_file_name_positive)=O170.raw; RAW_FILE_NAME(Raw_file_name_negative)=ON170.raw SUBJECT_SAMPLE_FACTORS DUMMY3 172 Sample source:Oral wash | Group:A RAW_FILE_NAME(Raw_file_name_positive)=O172.raw; RAW_FILE_NAME(Raw_file_name_negative)=ON172.raw SUBJECT_SAMPLE_FACTORS DUMMY4 174 Sample source:Oral wash | Group:A RAW_FILE_NAME(Raw_file_name_positive)=O174.raw; RAW_FILE_NAME(Raw_file_name_negative)=ON174.raw SUBJECT_SAMPLE_FACTORS DUMMY6 178 Sample source:Oral wash | Group:A RAW_FILE_NAME(Raw_file_name_positive)=O178.raw; RAW_FILE_NAME(Raw_file_name_negative)=ON178.raw SUBJECT_SAMPLE_FACTORS DUMMY5 182 Sample source:Oral wash | Group:A RAW_FILE_NAME(Raw_file_name_positive)=O182.raw; RAW_FILE_NAME(Raw_file_name_negative)=ON182.raw SUBJECT_SAMPLE_FACTORS DUMMY172 184 Sample source:Oral wash | Group:A RAW_FILE_NAME(Raw_file_name_positive)=O184.raw; RAW_FILE_NAME(Raw_file_name_negative)=ON184.raw SUBJECT_SAMPLE_FACTORS DUMMY174 186 Sample source:Oral wash | Group:A RAW_FILE_NAME(Raw_file_name_positive)=O186.raw; RAW_FILE_NAME(Raw_file_name_negative)=ON186.raw SUBJECT_SAMPLE_FACTORS DUMMY175 187 Sample source:Oral wash | Group:A RAW_FILE_NAME(Raw_file_name_positive)=O187.raw; RAW_FILE_NAME(Raw_file_name_negative)=ON187.raw SUBJECT_SAMPLE_FACTORS DUMMY178 190 Sample source:Oral wash | Group:A RAW_FILE_NAME(Raw_file_name_positive)=O190.raw; RAW_FILE_NAME(Raw_file_name_negative)=ON190.raw SUBJECT_SAMPLE_FACTORS DUMMY180 192 Sample source:Oral wash | Group:A RAW_FILE_NAME(Raw_file_name_positive)=O192.raw; RAW_FILE_NAME(Raw_file_name_negative)=ON192.raw SUBJECT_SAMPLE_FACTORS DUMMY182 194 Sample source:Oral wash | Group:A RAW_FILE_NAME(Raw_file_name_positive)=O194.raw; RAW_FILE_NAME(Raw_file_name_negative)=ON194.raw SUBJECT_SAMPLE_FACTORS DUMMY183 195 Sample source:Oral wash | Group:A RAW_FILE_NAME(Raw_file_name_positive)=O195.raw; RAW_FILE_NAME(Raw_file_name_negative)=ON195.raw SUBJECT_SAMPLE_FACTORS DUMMY185 199 Sample source:Oral wash | Group:A RAW_FILE_NAME(Raw_file_name_positive)=O199.raw; RAW_FILE_NAME(Raw_file_name_negative)=ON199.raw SUBJECT_SAMPLE_FACTORS DUMMY37 203 Sample source:Oral wash | Group:A RAW_FILE_NAME(Raw_file_name_positive)=O203.raw; RAW_FILE_NAME(Raw_file_name_negative)=ON203.raw SUBJECT_SAMPLE_FACTORS DUMMY187 207 Sample source:Oral wash | Group:A RAW_FILE_NAME(Raw_file_name_positive)=O207.raw; RAW_FILE_NAME(Raw_file_name_negative)=ON207.raw SUBJECT_SAMPLE_FACTORS DUMMY21 208 Sample source:Oral wash | Group:A RAW_FILE_NAME(Raw_file_name_positive)=O208.raw; RAW_FILE_NAME(Raw_file_name_negative)=ON208.raw SUBJECT_SAMPLE_FACTORS DUMMY22 210 Sample source:Oral wash | Group:A RAW_FILE_NAME(Raw_file_name_positive)=O210.raw; RAW_FILE_NAME(Raw_file_name_negative)=ON210.raw SUBJECT_SAMPLE_FACTORS DUMMY40 211 Sample source:Oral wash | Group:A RAW_FILE_NAME(Raw_file_name_positive)=O211.raw; RAW_FILE_NAME(Raw_file_name_negative)=ON211.raw SUBJECT_SAMPLE_FACTORS DUMMY41 213 Sample source:Oral wash | Group:A RAW_FILE_NAME(Raw_file_name_positive)=O213.raw; RAW_FILE_NAME(Raw_file_name_negative)=ON213.raw SUBJECT_SAMPLE_FACTORS DUMMY190 218 Sample source:Oral wash | Group:A RAW_FILE_NAME(Raw_file_name_positive)=O218.raw; RAW_FILE_NAME(Raw_file_name_negative)=ON218.raw SUBJECT_SAMPLE_FACTORS DUMMY23 220 Sample source:Oral wash | Group:A RAW_FILE_NAME(Raw_file_name_positive)=O220.raw; RAW_FILE_NAME(Raw_file_name_negative)=ON220.raw SUBJECT_SAMPLE_FACTORS DUMMY192 222 Sample source:Oral wash | Group:A RAW_FILE_NAME(Raw_file_name_positive)=O222.raw; RAW_FILE_NAME(Raw_file_name_negative)=ON222.raw SUBJECT_SAMPLE_FACTORS DUMMY193 225 Sample source:Oral wash | Group:A RAW_FILE_NAME(Raw_file_name_positive)=O225.raw; RAW_FILE_NAME(Raw_file_name_negative)=ON225.raw SUBJECT_SAMPLE_FACTORS DUMMY25 226 Sample source:Oral wash | Group:A RAW_FILE_NAME(Raw_file_name_positive)=O226.raw; RAW_FILE_NAME(Raw_file_name_negative)=ON226.raw SUBJECT_SAMPLE_FACTORS DUMMY60 231 Sample source:Oral wash | Group:A RAW_FILE_NAME(Raw_file_name_positive)=O231.raw; RAW_FILE_NAME(Raw_file_name_negative)=ON231.raw SUBJECT_SAMPLE_FACTORS DUMMY195 233 Sample source:Oral wash | Group:A RAW_FILE_NAME(Raw_file_name_positive)=O233.raw; RAW_FILE_NAME(Raw_file_name_negative)=ON233.raw SUBJECT_SAMPLE_FACTORS DUMMY30 234 Sample source:Oral wash | Group:A RAW_FILE_NAME(Raw_file_name_positive)=O234.raw; RAW_FILE_NAME(Raw_file_name_negative)=ON234.raw SUBJECT_SAMPLE_FACTORS DUMMY198 238 Sample source:Oral wash | Group:A RAW_FILE_NAME(Raw_file_name_positive)=O238.raw; RAW_FILE_NAME(Raw_file_name_negative)=ON238.raw SUBJECT_SAMPLE_FACTORS DUMMY24 239 Sample source:Oral wash | Group:A RAW_FILE_NAME(Raw_file_name_positive)=O239.raw; RAW_FILE_NAME(Raw_file_name_negative)=ON239.raw SUBJECT_SAMPLE_FACTORS DUMMY200 245 Sample source:Oral wash | Group:A RAW_FILE_NAME(Raw_file_name_positive)=O245.raw; RAW_FILE_NAME(Raw_file_name_negative)=ON245.raw SUBJECT_SAMPLE_FACTORS DUMMY46 248 Sample source:Oral wash | Group:A RAW_FILE_NAME(Raw_file_name_positive)=O248.raw; RAW_FILE_NAME(Raw_file_name_negative)=ON248.raw SUBJECT_SAMPLE_FACTORS DUMMY203 250 Sample source:Oral wash | Group:A RAW_FILE_NAME(Raw_file_name_positive)=O250.raw; RAW_FILE_NAME(Raw_file_name_negative)=ON250.raw SUBJECT_SAMPLE_FACTORS DUMMY204 251 Sample source:Oral wash | Group:A RAW_FILE_NAME(Raw_file_name_positive)=O251.raw; RAW_FILE_NAME(Raw_file_name_negative)=ON251.raw SUBJECT_SAMPLE_FACTORS DUMMY206 253 Sample source:Oral wash | Group:A RAW_FILE_NAME(Raw_file_name_positive)=O253.raw; RAW_FILE_NAME(Raw_file_name_negative)=ON253.raw SUBJECT_SAMPLE_FACTORS DUMMY28 256 Sample source:Oral wash | Group:A RAW_FILE_NAME(Raw_file_name_positive)=O256.raw; RAW_FILE_NAME(Raw_file_name_negative)=ON256.raw SUBJECT_SAMPLE_FACTORS DUMMY207 258 Sample source:Oral wash | Group:A RAW_FILE_NAME(Raw_file_name_positive)=O258.raw; RAW_FILE_NAME(Raw_file_name_negative)=ON258.raw SUBJECT_SAMPLE_FACTORS DUMMY208 261 Sample source:Oral wash | Group:A RAW_FILE_NAME(Raw_file_name_positive)=O261.raw; RAW_FILE_NAME(Raw_file_name_negative)=ON261.raw SUBJECT_SAMPLE_FACTORS DUMMY212 265 Sample source:Oral wash | Group:A RAW_FILE_NAME(Raw_file_name_positive)=O265.raw; RAW_FILE_NAME(Raw_file_name_negative)=ON265.raw SUBJECT_SAMPLE_FACTORS DUMMY214 267 Sample source:Oral wash | Group:A RAW_FILE_NAME(Raw_file_name_positive)=O267.raw; RAW_FILE_NAME(Raw_file_name_negative)=ON267.raw SUBJECT_SAMPLE_FACTORS DUMMY217 270 Sample source:Oral wash | Group:A RAW_FILE_NAME(Raw_file_name_positive)=O270.raw; RAW_FILE_NAME(Raw_file_name_negative)=ON270.raw SUBJECT_SAMPLE_FACTORS DUMMY16 273 Sample source:Oral wash | Group:A RAW_FILE_NAME(Raw_file_name_positive)=O273.raw; RAW_FILE_NAME(Raw_file_name_negative)=ON273.raw SUBJECT_SAMPLE_FACTORS DUMMY53 275 Sample source:Oral wash | Group:A RAW_FILE_NAME(Raw_file_name_positive)=O275.raw; RAW_FILE_NAME(Raw_file_name_negative)=ON275.raw SUBJECT_SAMPLE_FACTORS DUMMY218 277 Sample source:Oral wash | Group:A RAW_FILE_NAME(Raw_file_name_positive)=O277.raw; RAW_FILE_NAME(Raw_file_name_negative)=ON277.raw SUBJECT_SAMPLE_FACTORS DUMMY15 278 Sample source:Oral wash | Group:A RAW_FILE_NAME(Raw_file_name_positive)=O278.raw; RAW_FILE_NAME(Raw_file_name_negative)=ON278.raw SUBJECT_SAMPLE_FACTORS DUMMY14 280 Sample source:Oral wash | Group:A RAW_FILE_NAME(Raw_file_name_positive)=O280.raw; RAW_FILE_NAME(Raw_file_name_negative)=ON280.raw SUBJECT_SAMPLE_FACTORS DUMMY219 282 Sample source:Oral wash | Group:A RAW_FILE_NAME(Raw_file_name_positive)=O282.raw; RAW_FILE_NAME(Raw_file_name_negative)=ON282.raw SUBJECT_SAMPLE_FACTORS DUMMY7 285 Sample source:Oral wash | Group:A RAW_FILE_NAME(Raw_file_name_positive)=O285.raw; RAW_FILE_NAME(Raw_file_name_negative)=ON285.raw SUBJECT_SAMPLE_FACTORS DUMMY220 287 Sample source:Oral wash | Group:A RAW_FILE_NAME(Raw_file_name_positive)=O287.raw; RAW_FILE_NAME(Raw_file_name_negative)=ON287.raw SUBJECT_SAMPLE_FACTORS DUMMY10 289 Sample source:Oral wash | Group:A RAW_FILE_NAME(Raw_file_name_positive)=O289.raw; RAW_FILE_NAME(Raw_file_name_negative)=ON289.raw SUBJECT_SAMPLE_FACTORS DUMMY222 291 Sample source:Oral wash | Group:A RAW_FILE_NAME(Raw_file_name_positive)=O291.raw; RAW_FILE_NAME(Raw_file_name_negative)=ON291.raw SUBJECT_SAMPLE_FACTORS DUMMY9 294 Sample source:Oral wash | Group:A RAW_FILE_NAME(Raw_file_name_positive)=O294.raw; RAW_FILE_NAME(Raw_file_name_negative)=ON294.raw SUBJECT_SAMPLE_FACTORS DUMMY223 298 Sample source:Oral wash | Group:A RAW_FILE_NAME(Raw_file_name_positive)=O298.raw; RAW_FILE_NAME(Raw_file_name_negative)=ON298.raw SUBJECT_SAMPLE_FACTORS DUMMY225 300 Sample source:Oral wash | Group:A RAW_FILE_NAME(Raw_file_name_positive)=O300.raw; RAW_FILE_NAME(Raw_file_name_negative)=ON300.raw SUBJECT_SAMPLE_FACTORS DUMMY226 303 Sample source:Oral wash | Group:A RAW_FILE_NAME(Raw_file_name_positive)=O303.raw; RAW_FILE_NAME(Raw_file_name_negative)=ON303.raw SUBJECT_SAMPLE_FACTORS DUMMY227 306 Sample source:Oral wash | Group:A RAW_FILE_NAME(Raw_file_name_positive)=O306.raw; RAW_FILE_NAME(Raw_file_name_negative)=ON306.raw SUBJECT_SAMPLE_FACTORS DUMMY12 307 Sample source:Oral wash | Group:A RAW_FILE_NAME(Raw_file_name_positive)=O307.raw; RAW_FILE_NAME(Raw_file_name_negative)=ON307.raw SUBJECT_SAMPLE_FACTORS DUMMY13 309 Sample source:Oral wash | Group:A RAW_FILE_NAME(Raw_file_name_positive)=O309.raw; RAW_FILE_NAME(Raw_file_name_negative)=ON309.raw SUBJECT_SAMPLE_FACTORS DUMMY228 311 Sample source:Oral wash | Group:A RAW_FILE_NAME(Raw_file_name_positive)=O311.raw; RAW_FILE_NAME(Raw_file_name_negative)=ON311.raw SUBJECT_SAMPLE_FACTORS DUMMY17 318 Sample source:Oral wash | Group:A RAW_FILE_NAME(Raw_file_name_positive)=O318.raw; RAW_FILE_NAME(Raw_file_name_negative)=ON318.raw SUBJECT_SAMPLE_FACTORS DUMMY233 322 Sample source:Oral wash | Group:A RAW_FILE_NAME(Raw_file_name_positive)=O322.raw; RAW_FILE_NAME(Raw_file_name_negative)=ON322.raw SUBJECT_SAMPLE_FACTORS DUMMY48 323 Sample source:Oral wash | Group:A RAW_FILE_NAME(Raw_file_name_positive)=O323.raw; RAW_FILE_NAME(Raw_file_name_negative)=ON323.raw SUBJECT_SAMPLE_FACTORS DUMMY43 325 Sample source:Oral wash | Group:A RAW_FILE_NAME(Raw_file_name_positive)=O325.raw; RAW_FILE_NAME(Raw_file_name_negative)=ON325.raw SUBJECT_SAMPLE_FACTORS DUMMY234 327 Sample source:Oral wash | Group:A RAW_FILE_NAME(Raw_file_name_positive)=O327.raw; RAW_FILE_NAME(Raw_file_name_negative)=ON327.raw SUBJECT_SAMPLE_FACTORS DUMMY47 328 Sample source:Oral wash | Group:A RAW_FILE_NAME(Raw_file_name_positive)=O328.raw; RAW_FILE_NAME(Raw_file_name_negative)=ON328.raw SUBJECT_SAMPLE_FACTORS DUMMY235 332 Sample source:Oral wash | Group:A RAW_FILE_NAME(Raw_file_name_positive)=O332.raw; RAW_FILE_NAME(Raw_file_name_negative)=ON332.raw SUBJECT_SAMPLE_FACTORS DUMMY237 336 Sample source:Oral wash | Group:A RAW_FILE_NAME(Raw_file_name_positive)=O336.raw; RAW_FILE_NAME(Raw_file_name_negative)=ON336.raw SUBJECT_SAMPLE_FACTORS DUMMY50 338 Sample source:Oral wash | Group:A RAW_FILE_NAME(Raw_file_name_positive)=O338.raw; RAW_FILE_NAME(Raw_file_name_negative)=ON338.raw SUBJECT_SAMPLE_FACTORS DUMMY52 342 Sample source:Oral wash | Group:A RAW_FILE_NAME(Raw_file_name_positive)=O342.raw; RAW_FILE_NAME(Raw_file_name_negative)=ON342.raw SUBJECT_SAMPLE_FACTORS DUMMY239 344 Sample source:Oral wash | Group:A RAW_FILE_NAME(Raw_file_name_positive)=O344.raw; RAW_FILE_NAME(Raw_file_name_negative)=ON344.raw SUBJECT_SAMPLE_FACTORS DUMMY240 347 Sample source:Oral wash | Group:A RAW_FILE_NAME(Raw_file_name_positive)=O347.raw; RAW_FILE_NAME(Raw_file_name_negative)=ON347.raw SUBJECT_SAMPLE_FACTORS DUMMY243 350 Sample source:Oral wash | Group:A RAW_FILE_NAME(Raw_file_name_positive)=O350.raw; RAW_FILE_NAME(Raw_file_name_negative)=ON350.raw SUBJECT_SAMPLE_FACTORS DUMMY244 351 Sample source:Oral wash | Group:A RAW_FILE_NAME(Raw_file_name_positive)=O351.raw; RAW_FILE_NAME(Raw_file_name_negative)=ON351.raw SUBJECT_SAMPLE_FACTORS DUMMY54 352 Sample source:Oral wash | Group:A RAW_FILE_NAME(Raw_file_name_positive)=O352.raw; RAW_FILE_NAME(Raw_file_name_negative)=ON352.raw SUBJECT_SAMPLE_FACTORS DUMMY245 355 Sample source:Oral wash | Group:A RAW_FILE_NAME(Raw_file_name_positive)=O355.raw; RAW_FILE_NAME(Raw_file_name_negative)=ON355.raw SUBJECT_SAMPLE_FACTORS DUMMY246 356 Sample source:Oral wash | Group:A RAW_FILE_NAME(Raw_file_name_positive)=O356.raw; RAW_FILE_NAME(Raw_file_name_negative)=ON356.raw SUBJECT_SAMPLE_FACTORS DUMMY249 359 Sample source:Oral wash | Group:A RAW_FILE_NAME(Raw_file_name_positive)=O359.raw; RAW_FILE_NAME(Raw_file_name_negative)=ON359.raw SUBJECT_SAMPLE_FACTORS DUMMY253 363 Sample source:Oral wash | Group:A RAW_FILE_NAME(Raw_file_name_positive)=O363.raw; RAW_FILE_NAME(Raw_file_name_negative)=ON363.raw SUBJECT_SAMPLE_FACTORS DUMMY257 367 Sample source:Oral wash | Group:A RAW_FILE_NAME(Raw_file_name_positive)=O367.raw; RAW_FILE_NAME(Raw_file_name_negative)=ON367.raw SUBJECT_SAMPLE_FACTORS DUMMY258 368 Sample source:Oral wash | Group:A RAW_FILE_NAME(Raw_file_name_positive)=O368.raw; RAW_FILE_NAME(Raw_file_name_negative)=ON368.raw SUBJECT_SAMPLE_FACTORS DUMMY260 370 Sample source:Oral wash | Group:A RAW_FILE_NAME(Raw_file_name_positive)=O370.raw; RAW_FILE_NAME(Raw_file_name_negative)=ON370.raw SUBJECT_SAMPLE_FACTORS DUMMY263 373 Sample source:Oral wash | Group:A RAW_FILE_NAME(Raw_file_name_positive)=O373.raw; RAW_FILE_NAME(Raw_file_name_negative)=ON373.raw SUBJECT_SAMPLE_FACTORS DUMMY38 39 Sample source:Oral wash | Group:A RAW_FILE_NAME(Raw_file_name_positive)=O39.raw; RAW_FILE_NAME(Raw_file_name_negative)=ON39.raw SUBJECT_SAMPLE_FACTORS DUMMY116 50 Sample source:Oral wash | Group:A RAW_FILE_NAME(Raw_file_name_positive)=O50.raw; RAW_FILE_NAME(Raw_file_name_negative)=ON50.raw SUBJECT_SAMPLE_FACTORS DUMMY120 70 Sample source:Oral wash | Group:A RAW_FILE_NAME(Raw_file_name_positive)=O70.raw; RAW_FILE_NAME(Raw_file_name_negative)=ON70.raw SUBJECT_SAMPLE_FACTORS DUMMY124 74 Sample source:Oral wash | Group:A RAW_FILE_NAME(Raw_file_name_positive)=O74.raw; RAW_FILE_NAME(Raw_file_name_negative)=ON74.raw SUBJECT_SAMPLE_FACTORS DUMMY127 77 Sample source:Oral wash | Group:A RAW_FILE_NAME(Raw_file_name_positive)=O77.raw; RAW_FILE_NAME(Raw_file_name_negative)=ON77.raw SUBJECT_SAMPLE_FACTORS DUMMY130 80 Sample source:Oral wash | Group:A RAW_FILE_NAME(Raw_file_name_positive)=O80.raw; RAW_FILE_NAME(Raw_file_name_negative)=ON80.raw SUBJECT_SAMPLE_FACTORS DUMMY132 82 Sample source:Oral wash | Group:A RAW_FILE_NAME(Raw_file_name_positive)=O82.raw; RAW_FILE_NAME(Raw_file_name_negative)=ON82.raw SUBJECT_SAMPLE_FACTORS DUMMY133 83 Sample source:Oral wash | Group:A RAW_FILE_NAME(Raw_file_name_positive)=O83.raw; RAW_FILE_NAME(Raw_file_name_negative)=ON83.raw SUBJECT_SAMPLE_FACTORS DUMMY18 86 Sample source:Oral wash | Group:A RAW_FILE_NAME(Raw_file_name_positive)=O86.raw; RAW_FILE_NAME(Raw_file_name_negative)=ON86.raw SUBJECT_SAMPLE_FACTORS DUMMY136 88 Sample source:Oral wash | Group:A RAW_FILE_NAME(Raw_file_name_positive)=O88.raw; RAW_FILE_NAME(Raw_file_name_negative)=ON88.raw SUBJECT_SAMPLE_FACTORS DUMMY140 92 Sample source:Oral wash | Group:A RAW_FILE_NAME(Raw_file_name_positive)=O92.raw; RAW_FILE_NAME(Raw_file_name_negative)=ON92.raw SUBJECT_SAMPLE_FACTORS DUMMY141 93 Sample source:Oral wash | Group:A RAW_FILE_NAME(Raw_file_name_positive)=O93.raw; RAW_FILE_NAME(Raw_file_name_negative)=ON93.raw SUBJECT_SAMPLE_FACTORS DUMMY19 94 Sample source:Oral wash | Group:A RAW_FILE_NAME(Raw_file_name_positive)=O94.raw; RAW_FILE_NAME(Raw_file_name_negative)=ON94.raw SUBJECT_SAMPLE_FACTORS DUMMY67 99 Sample source:Oral wash | Group:A RAW_FILE_NAME(Raw_file_name_positive)=O99.raw; RAW_FILE_NAME(Raw_file_name_negative)=ON99.raw SUBJECT_SAMPLE_FACTORS DUMMY20 101 Sample source:Oral wash | Group:A RAW_FILE_NAME(Raw_file_name_positive)=O101.raw; RAW_FILE_NAME(Raw_file_name_negative)=ON101.raw SUBJECT_SAMPLE_FACTORS DUMMY145 103 Sample source:Oral wash | Group:A RAW_FILE_NAME(Raw_file_name_positive)=O103.raw; RAW_FILE_NAME(Raw_file_name_negative)=ON103.raw SUBJECT_SAMPLE_FACTORS DUMMY148 106 Sample source:Oral wash | Group:A RAW_FILE_NAME(Raw_file_name_positive)=O106.raw; RAW_FILE_NAME(Raw_file_name_negative)=ON106.raw SUBJECT_SAMPLE_FACTORS DUMMY68 107 Sample source:Oral wash | Group:A RAW_FILE_NAME(Raw_file_name_positive)=O107.raw; RAW_FILE_NAME(Raw_file_name_negative)=ON107.raw SUBJECT_SAMPLE_FACTORS DUMMY77 109 Sample source:Oral wash | Group:A RAW_FILE_NAME(Raw_file_name_positive)=O109.raw; RAW_FILE_NAME(Raw_file_name_negative)=ON109.raw SUBJECT_SAMPLE_FACTORS DUMMY69 118 Sample source:Oral wash | Group:A RAW_FILE_NAME(Raw_file_name_positive)=O118.raw; RAW_FILE_NAME(Raw_file_name_negative)=ON118.raw SUBJECT_SAMPLE_FACTORS DUMMY32 120 Sample source:Oral wash | Group:A RAW_FILE_NAME(Raw_file_name_positive)=O120.raw; RAW_FILE_NAME(Raw_file_name_negative)=ON120.raw SUBJECT_SAMPLE_FACTORS DUMMY70 125 Sample source:Oral wash | Group:A RAW_FILE_NAME(Raw_file_name_positive)=O125.raw; RAW_FILE_NAME(Raw_file_name_negative)=ON125.raw SUBJECT_SAMPLE_FACTORS DUMMY153 127 Sample source:Oral wash | Group:A RAW_FILE_NAME(Raw_file_name_positive)=O127.raw; RAW_FILE_NAME(Raw_file_name_negative)=ON127.raw SUBJECT_SAMPLE_FACTORS DUMMY154 128 Sample source:Oral wash | Group:A RAW_FILE_NAME(Raw_file_name_positive)=O128.raw; RAW_FILE_NAME(Raw_file_name_negative)=ON128.raw SUBJECT_SAMPLE_FACTORS DUMMY61 129 Sample source:Oral wash | Group:A RAW_FILE_NAME(Raw_file_name_positive)=O129.raw; RAW_FILE_NAME(Raw_file_name_negative)=ON129.raw SUBJECT_SAMPLE_FACTORS DUMMY157 135 Sample source:Oral wash | Group:A RAW_FILE_NAME(Raw_file_name_positive)=O135.raw; RAW_FILE_NAME(Raw_file_name_negative)=ON135.raw SUBJECT_SAMPLE_FACTORS DUMMY45 147 Sample source:Oral wash | Group:A RAW_FILE_NAME(Raw_file_name_positive)=O147.raw; RAW_FILE_NAME(Raw_file_name_negative)=ON147.raw SUBJECT_SAMPLE_FACTORS DUMMY163 153 Sample source:Oral wash | Group:A RAW_FILE_NAME(Raw_file_name_positive)=O153.raw; RAW_FILE_NAME(Raw_file_name_negative)=ON153.raw SUBJECT_SAMPLE_FACTORS DUMMY72 154 Sample source:Oral wash | Group:A RAW_FILE_NAME(Raw_file_name_positive)=O154.raw; RAW_FILE_NAME(Raw_file_name_negative)=ON154.raw SUBJECT_SAMPLE_FACTORS DUMMY164 156 Sample source:Oral wash | Group:A RAW_FILE_NAME(Raw_file_name_positive)=O156.raw; RAW_FILE_NAME(Raw_file_name_negative)=ON156.raw SUBJECT_SAMPLE_FACTORS DUMMY170 168 Sample source:Oral wash | Group:A RAW_FILE_NAME(Raw_file_name_positive)=O168.raw; RAW_FILE_NAME(Raw_file_name_negative)=ON168.raw SUBJECT_SAMPLE_FACTORS DUMMY62 176 Sample source:Oral wash | Group:A RAW_FILE_NAME(Raw_file_name_positive)=O176.raw; RAW_FILE_NAME(Raw_file_name_negative)=ON176.raw SUBJECT_SAMPLE_FACTORS DUMMY78 180 Sample source:Oral wash | Group:A RAW_FILE_NAME(Raw_file_name_positive)=O180.raw; RAW_FILE_NAME(Raw_file_name_negative)=ON180.raw SUBJECT_SAMPLE_FACTORS DUMMY176 188 Sample source:Oral wash | Group:A RAW_FILE_NAME(Raw_file_name_positive)=O188.raw; RAW_FILE_NAME(Raw_file_name_negative)=ON188.raw SUBJECT_SAMPLE_FACTORS DUMMY177 189 Sample source:Oral wash | Group:A RAW_FILE_NAME(Raw_file_name_positive)=O189.raw; RAW_FILE_NAME(Raw_file_name_negative)=ON189.raw SUBJECT_SAMPLE_FACTORS DUMMY179 191 Sample source:Oral wash | Group:A RAW_FILE_NAME(Raw_file_name_positive)=O191.raw; RAW_FILE_NAME(Raw_file_name_negative)=ON191.raw SUBJECT_SAMPLE_FACTORS DUMMY181 193 Sample source:Oral wash | Group:A RAW_FILE_NAME(Raw_file_name_positive)=O193.raw; RAW_FILE_NAME(Raw_file_name_negative)=ON193.raw SUBJECT_SAMPLE_FACTORS DUMMY184 196 Sample source:Oral wash | Group:A RAW_FILE_NAME(Raw_file_name_positive)=O196.raw; RAW_FILE_NAME(Raw_file_name_negative)=ON196.raw SUBJECT_SAMPLE_FACTORS DUMMY79 197 Sample source:Oral wash | Group:A RAW_FILE_NAME(Raw_file_name_positive)=O197.raw; RAW_FILE_NAME(Raw_file_name_negative)=ON197.raw SUBJECT_SAMPLE_FACTORS DUMMY186 200 Sample source:Oral wash | Group:A RAW_FILE_NAME(Raw_file_name_positive)=O200.raw; RAW_FILE_NAME(Raw_file_name_negative)=ON200.raw SUBJECT_SAMPLE_FACTORS DUMMY33 201 Sample source:Oral wash | Group:A RAW_FILE_NAME(Raw_file_name_positive)=O201.raw; RAW_FILE_NAME(Raw_file_name_negative)=ON201.raw SUBJECT_SAMPLE_FACTORS DUMMY80 205 Sample source:Oral wash | Group:A RAW_FILE_NAME(Raw_file_name_positive)=O205.raw; RAW_FILE_NAME(Raw_file_name_negative)=ON205.raw SUBJECT_SAMPLE_FACTORS DUMMY71 215 Sample source:Oral wash | Group:A RAW_FILE_NAME(Raw_file_name_positive)=O215.raw; RAW_FILE_NAME(Raw_file_name_negative)=ON215.raw SUBJECT_SAMPLE_FACTORS DUMMY189 217 Sample source:Oral wash | Group:A RAW_FILE_NAME(Raw_file_name_positive)=O217.raw; RAW_FILE_NAME(Raw_file_name_negative)=ON217.raw SUBJECT_SAMPLE_FACTORS DUMMY191 219 Sample source:Oral wash | Group:A RAW_FILE_NAME(Raw_file_name_positive)=O219.raw; RAW_FILE_NAME(Raw_file_name_negative)=ON219.raw SUBJECT_SAMPLE_FACTORS DUMMY63 223 Sample source:Oral wash | Group:A RAW_FILE_NAME(Raw_file_name_positive)=O223.raw; RAW_FILE_NAME(Raw_file_name_negative)=ON223.raw SUBJECT_SAMPLE_FACTORS DUMMY26 229 Sample source:Oral wash | Group:A RAW_FILE_NAME(Raw_file_name_positive)=O229.raw; RAW_FILE_NAME(Raw_file_name_negative)=ON229.raw SUBJECT_SAMPLE_FACTORS DUMMY196 236 Sample source:Oral wash | Group:A RAW_FILE_NAME(Raw_file_name_positive)=O236.raw; RAW_FILE_NAME(Raw_file_name_negative)=ON236.raw SUBJECT_SAMPLE_FACTORS DUMMY197 237 Sample source:Oral wash | Group:A RAW_FILE_NAME(Raw_file_name_positive)=O237.raw; RAW_FILE_NAME(Raw_file_name_negative)=ON237.raw SUBJECT_SAMPLE_FACTORS DUMMY27 242 Sample source:Oral wash | Group:A RAW_FILE_NAME(Raw_file_name_positive)=O242.raw; RAW_FILE_NAME(Raw_file_name_negative)=ON242.raw SUBJECT_SAMPLE_FACTORS DUMMY199 244 Sample source:Oral wash | Group:A RAW_FILE_NAME(Raw_file_name_positive)=O244.raw; RAW_FILE_NAME(Raw_file_name_negative)=ON244.raw SUBJECT_SAMPLE_FACTORS DUMMY201 246 Sample source:Oral wash | Group:A RAW_FILE_NAME(Raw_file_name_positive)=O246.raw; RAW_FILE_NAME(Raw_file_name_negative)=ON246.raw SUBJECT_SAMPLE_FACTORS DUMMY202 247 Sample source:Oral wash | Group:A RAW_FILE_NAME(Raw_file_name_positive)=O247.raw; RAW_FILE_NAME(Raw_file_name_negative)=ON247.raw SUBJECT_SAMPLE_FACTORS DUMMY205 252 Sample source:Oral wash | Group:A RAW_FILE_NAME(Raw_file_name_positive)=O252.raw; RAW_FILE_NAME(Raw_file_name_negative)=ON252.raw SUBJECT_SAMPLE_FACTORS DUMMY29 254 Sample source:Oral wash | Group:A RAW_FILE_NAME(Raw_file_name_positive)=O254.raw; RAW_FILE_NAME(Raw_file_name_negative)=ON254.raw SUBJECT_SAMPLE_FACTORS DUMMY209 262 Sample source:Oral wash | Group:A RAW_FILE_NAME(Raw_file_name_positive)=O262.raw; RAW_FILE_NAME(Raw_file_name_negative)=ON262.raw SUBJECT_SAMPLE_FACTORS DUMMY210 263 Sample source:Oral wash | Group:A RAW_FILE_NAME(Raw_file_name_positive)=O263.raw; RAW_FILE_NAME(Raw_file_name_negative)=ON263.raw SUBJECT_SAMPLE_FACTORS DUMMY211 264 Sample source:Oral wash | Group:A RAW_FILE_NAME(Raw_file_name_positive)=O264.raw; RAW_FILE_NAME(Raw_file_name_negative)=ON264.raw SUBJECT_SAMPLE_FACTORS DUMMY216 269 Sample source:Oral wash | Group:A RAW_FILE_NAME(Raw_file_name_positive)=O269.raw; RAW_FILE_NAME(Raw_file_name_negative)=ON269.raw SUBJECT_SAMPLE_FACTORS DUMMY42 271 Sample source:Oral wash | Group:A RAW_FILE_NAME(Raw_file_name_positive)=O271.raw; RAW_FILE_NAME(Raw_file_name_negative)=ON271.raw SUBJECT_SAMPLE_FACTORS DUMMY73 283 Sample source:Oral wash | Group:A RAW_FILE_NAME(Raw_file_name_positive)=O283.raw; RAW_FILE_NAME(Raw_file_name_negative)=ON283.raw SUBJECT_SAMPLE_FACTORS DUMMY11 296 Sample source:Oral wash | Group:A RAW_FILE_NAME(Raw_file_name_positive)=O296.raw; RAW_FILE_NAME(Raw_file_name_negative)=ON296.raw SUBJECT_SAMPLE_FACTORS DUMMY64 301 Sample source:Oral wash | Group:A RAW_FILE_NAME(Raw_file_name_positive)=O301.raw; RAW_FILE_NAME(Raw_file_name_negative)=ON301.raw SUBJECT_SAMPLE_FACTORS DUMMY65 304 Sample source:Oral wash | Group:A RAW_FILE_NAME(Raw_file_name_positive)=O304.raw; RAW_FILE_NAME(Raw_file_name_negative)=ON304.raw SUBJECT_SAMPLE_FACTORS DUMMY66 312 Sample source:Oral wash | Group:A RAW_FILE_NAME(Raw_file_name_positive)=O312.raw; RAW_FILE_NAME(Raw_file_name_negative)=ON312.raw SUBJECT_SAMPLE_FACTORS DUMMY231 316 Sample source:Oral wash | Group:A RAW_FILE_NAME(Raw_file_name_positive)=O316.raw; RAW_FILE_NAME(Raw_file_name_negative)=ON316.raw SUBJECT_SAMPLE_FACTORS DUMMY232 317 Sample source:Oral wash | Group:A RAW_FILE_NAME(Raw_file_name_positive)=O317.raw; RAW_FILE_NAME(Raw_file_name_negative)=ON317.raw SUBJECT_SAMPLE_FACTORS DUMMY74 320 Sample source:Oral wash | Group:A RAW_FILE_NAME(Raw_file_name_positive)=O320.raw; RAW_FILE_NAME(Raw_file_name_negative)=ON320.raw SUBJECT_SAMPLE_FACTORS DUMMY75 330 Sample source:Oral wash | Group:A RAW_FILE_NAME(Raw_file_name_positive)=O330.raw; RAW_FILE_NAME(Raw_file_name_negative)=ON330.raw SUBJECT_SAMPLE_FACTORS DUMMY49 333 Sample source:Oral wash | Group:A RAW_FILE_NAME(Raw_file_name_positive)=O333.raw; RAW_FILE_NAME(Raw_file_name_negative)=ON333.raw SUBJECT_SAMPLE_FACTORS DUMMY236 335 Sample source:Oral wash | Group:A RAW_FILE_NAME(Raw_file_name_positive)=O335.raw; RAW_FILE_NAME(Raw_file_name_negative)=ON335.raw SUBJECT_SAMPLE_FACTORS DUMMY51 340 Sample source:Oral wash | Group:A RAW_FILE_NAME(Raw_file_name_positive)=O340.raw; RAW_FILE_NAME(Raw_file_name_negative)=ON340.raw SUBJECT_SAMPLE_FACTORS DUMMY81 345 Sample source:Oral wash | Group:A RAW_FILE_NAME(Raw_file_name_positive)=O345.raw; RAW_FILE_NAME(Raw_file_name_negative)=ON345.raw SUBJECT_SAMPLE_FACTORS DUMMY242 349 Sample source:Oral wash | Group:A RAW_FILE_NAME(Raw_file_name_positive)=O349.raw; RAW_FILE_NAME(Raw_file_name_negative)=ON349.raw SUBJECT_SAMPLE_FACTORS DUMMY247 357 Sample source:Oral wash | Group:A RAW_FILE_NAME(Raw_file_name_positive)=O357.raw; RAW_FILE_NAME(Raw_file_name_negative)=ON357.raw SUBJECT_SAMPLE_FACTORS DUMMY248 358 Sample source:Oral wash | Group:A RAW_FILE_NAME(Raw_file_name_positive)=O358.raw; RAW_FILE_NAME(Raw_file_name_negative)=ON358.raw SUBJECT_SAMPLE_FACTORS DUMMY250 360 Sample source:Oral wash | Group:A RAW_FILE_NAME(Raw_file_name_positive)=O360.raw; RAW_FILE_NAME(Raw_file_name_negative)=ON360.raw SUBJECT_SAMPLE_FACTORS DUMMY251 361 Sample source:Oral wash | Group:A RAW_FILE_NAME(Raw_file_name_positive)=O361.raw; RAW_FILE_NAME(Raw_file_name_negative)=ON361.raw SUBJECT_SAMPLE_FACTORS DUMMY252 362 Sample source:Oral wash | Group:A RAW_FILE_NAME(Raw_file_name_positive)=O362.raw; RAW_FILE_NAME(Raw_file_name_negative)=ON362.raw SUBJECT_SAMPLE_FACTORS DUMMY255 365 Sample source:Oral wash | Group:A RAW_FILE_NAME(Raw_file_name_positive)=O365.raw; RAW_FILE_NAME(Raw_file_name_negative)=ON365.raw SUBJECT_SAMPLE_FACTORS DUMMY256 366 Sample source:Oral wash | Group:A RAW_FILE_NAME(Raw_file_name_positive)=O366.raw; RAW_FILE_NAME(Raw_file_name_negative)=ON366.raw SUBJECT_SAMPLE_FACTORS DUMMY259 369 Sample source:Oral wash | Group:A RAW_FILE_NAME(Raw_file_name_positive)=O369.raw; RAW_FILE_NAME(Raw_file_name_negative)=ON369.raw SUBJECT_SAMPLE_FACTORS DUMMY261 371 Sample source:Oral wash | Group:A RAW_FILE_NAME(Raw_file_name_positive)=O371.raw; RAW_FILE_NAME(Raw_file_name_negative)=ON371.raw SUBJECT_SAMPLE_FACTORS DUMMY262 372 Sample source:Oral wash | Group:A RAW_FILE_NAME(Raw_file_name_positive)=O372.raw; RAW_FILE_NAME(Raw_file_name_negative)=ON372.raw SUBJECT_SAMPLE_FACTORS DUMMY264 374 Sample source:Oral wash | Group:A RAW_FILE_NAME(Raw_file_name_positive)=O374.raw; RAW_FILE_NAME(Raw_file_name_negative)=ON374.raw SUBJECT_SAMPLE_FACTORS DUMMY265 375 Sample source:Oral wash | Group:A RAW_FILE_NAME(Raw_file_name_positive)=O375.raw; RAW_FILE_NAME(Raw_file_name_negative)=ON375.raw #COLLECTION CO:COLLECTION_SUMMARY Oral wash samples obtained from participants during their first Multicenter AIDS CO:COLLECTION_SUMMARY Cohort Study (MACS) clinic visit and were preserved at −80°C without CO:COLLECTION_SUMMARY additives or preservatives(Chen et al 2021, Microbiome) CO:SAMPLE_TYPE Saliva #TREATMENT TR:TREATMENT_SUMMARY This study includes Men who have Sex with Men (MSM) enrolled in the Multicenter TR:TREATMENT_SUMMARY AIDS Cohort study (MACS). All participants were HIV-1-negative during their TR:TREATMENT_SUMMARY first MACS clinic visit when samples were collected. This study compares gut, TR:TREATMENT_SUMMARY plasma, and oral metabolic profiles between those who became infected with HIV-1 TR:TREATMENT_SUMMARY by their second study clinic visit approximately 6 months later (termed Pre-HIV) TR:TREATMENT_SUMMARY and those who remained HIV-negative (termed Non-HIV) at their second MACS clinic TR:TREATMENT_SUMMARY visit. #SAMPLEPREP SP:SAMPLEPREP_SUMMARY Sample were thawed on ice and transfer 200 μL sample into tube, added with 300 SP:SAMPLEPREP_SUMMARY μL methanol. All samples were vortexed 30 s, and followed by sonication for 30 SP:SAMPLEPREP_SUMMARY min, 4°C. Then each sample was kept at -20°C for 1 h, vortexed for 30 s and SP:SAMPLEPREP_SUMMARY kept at 4°C for 30 min. After that, samples were centrifuged at 12,000 rpm and SP:SAMPLEPREP_SUMMARY 4°C for 15 min. All the supernatant was transferred to a new tube, keep at SP:SAMPLEPREP_SUMMARY -20°C for 1 h, centrifuged at 12,000 rpm and 4°C for 15 min. Finally, 200 μL SP:SAMPLEPREP_SUMMARY of supernatant into vial and 5 μL of 0.14 mg/mL DL-o-Chlorophenylalanine as SP:SAMPLEPREP_SUMMARY internal standard, filtered through a 0.22 μm filter for LC-MS analysis. #CHROMATOGRAPHY CH:CHROMATOGRAPHY_TYPE Reversed phase CH:INSTRUMENT_NAME Waters Acquity CH:COLUMN_NAME Waters ACQUITY UPLC HSS T3 (100 x 2.1 mm,1.8 μm) CH:SOLVENT_A 100% Water; 0.05% Formic acid CH:SOLVENT_B 100% Acetonitrile CH:FLOW_GRADIENT 0-1.0 min, 5% B; 1.0-12.5 min, 5%-95% B; 12.5-13.5 min, 95% B; 13.5-13.6 min, CH:FLOW_GRADIENT 95%-5% B; 13.6-16 min, 5% B CH:FLOW_RATE 0.3 mL/min CH:COLUMN_TEMPERATURE 40°C #ANALYSIS AN:ANALYSIS_TYPE MS #MS MS:INSTRUMENT_NAME Thermo Q Exactive Orbitrap MS:INSTRUMENT_TYPE Orbitrap MS:MS_TYPE ESI MS:ION_MODE NEGATIVE MS:MS_COMMENTS The electrospray ionization positive mode was operated using following MS:MS_COMMENTS conditions: heater temperature of 300°C, sheath gas flow rate of 45 arb, aux MS:MS_COMMENTS gas flow rate of 15 arb, sweep gas flow rate of 1 arb, spray voltage of 3.2 KV, MS:MS_COMMENTS capillary temperature of 350°C and S-Lens RF level set constant at 60%.The full MS:MS_COMMENTS scan was performed 70-1050 m/z at the resolution of 70,000 fwhm, automatic gain MS:MS_COMMENTS control (AGC) target of 3×106, maximum injection time of 100 ms and spectrum MS:MS_COMMENTS data type of centroid. Significant features were identified using data-dependent MS:MS_COMMENTS MS2. Settings for dd-MS2 data acquisition was as follows, resolution of 17,500 MS:MS_COMMENTS fwhm, AGC target of 1×105, maximum injection time of 50 ms, isolation window of MS:MS_COMMENTS 1.7 m/z, loop count of 10, and normalized collision energy (NCE) was set at 15, MS:MS_COMMENTS 30 and 45 eV, spectrum data type of centroid. The Compound Discoverer 3.1 MS:MS_COMMENTS (CD3.1, Thermo Fisher) software was used to process raw data generated by the MS:MS_COMMENTS UPLC-MS via peak alignment, peak picking, and identification of each metabolite. MS:MS_COMMENTS After analysis, these data were matched with the mzCloud, mzVault databases to MS:MS_COMMENTS obtain accurate identification results. The data was further processed by MS:MS_COMMENTS Progenesis QI to provide strong support for identifying metabolites accurately. MS:MS_RESULTS_FILE ST004209_AN007001_Results.txt UNITS:Peak area Has m/z:Yes Has RT:Yes RT units:Minutes #END