#METABOLOMICS WORKBENCH Hanlab_20250909_063517 DATATRACK_ID:6405 STUDY_ID:ST004223 ANALYSIS_ID:AN007027 PROJECT_ID:PR002664
VERSION             	1
CREATED_ON             	September 25, 2025, 8:20 pm
#PROJECT
PR:PROJECT_TITLE                 	Sulfatide deficiency-induced alterations in myelin lipids are independent of
PR:PROJECT_TITLE                 	Trem2
PR:PROJECT_SUMMARY               	Disrupted lipid homeostasis and neuroinflammation often co-exist in
PR:PROJECT_SUMMARY               	neurodegenerative disorders including Alzheimer’s disease (AD). However, the
PR:PROJECT_SUMMARY               	intrinsic connection and causal relationship between these deficits remain
PR:PROJECT_SUMMARY               	elusive. Our previous studies show that the loss of sulfatide (ST), a class of
PR:PROJECT_SUMMARY               	myelin-enriched lipids, causes AD-like neuroinflammatory responses, cognitive
PR:PROJECT_SUMMARY               	impairment, bladder enlargement, and lipid dyshomeostasis. To better understand
PR:PROJECT_SUMMARY               	the relationship between neuroinflammation and lipid disruption induced by ST
PR:PROJECT_SUMMARY               	deficiency, we established a ST-deficient mouse model with a constitutive Trem2
PR:PROJECT_SUMMARY               	knockout. Our study demonstrated that Trem2 regulates ST deficiency-induced
PR:PROJECT_SUMMARY               	neuroinflammation and astrocyte activation at the transcriptomic level but does
PR:PROJECT_SUMMARY               	not affect stage 1 disease-associated microglia or astrogliosis at the protein
PR:PROJECT_SUMMARY               	level. Additionally, ST loss-induced lipidome disruption, free water retention,
PR:PROJECT_SUMMARY               	and cognitive impairment were consistently observed in the absence of Trem2.
PR:PROJECT_SUMMARY               	Further, these phenotypes were more severe in females compared to males.
PR:PROJECT_SUMMARY               	Collectively, these results emphasize the essential role of Trem2 in mediating
PR:PROJECT_SUMMARY               	lipid loss-associated microglia mediated neuroinflammation, but not astrogliosis
PR:PROJECT_SUMMARY               	or myelin lipid disruption. Moreover, we demonstrated that attenuating
PR:PROJECT_SUMMARY               	Trem2-mediated neuroinflammation has a limited impact on brain ST loss-induced
PR:PROJECT_SUMMARY               	lipidome alteration or AD-like central and peripheral disorders. Our findings
PR:PROJECT_SUMMARY               	suggest that preserving the lipidome and astrocyte balance may be crucial in
PR:PROJECT_SUMMARY               	decelerating the progression of AD.
PR:INSTITUTE                     	UT Health San Antonio
PR:LAST_NAME                     	Han
PR:FIRST_NAME                    	Xianlin
PR:ADDRESS                       	4939 Charles Katz Dr, San Antonio, TX
PR:EMAIL                         	hanx@uthscsa.edu
PR:PHONE                         	2105624104
#STUDY
ST:STUDY_TITLE                   	Sulfatide deficiency-induced astrogliosis and myelin lipid dyshomeostasis are
ST:STUDY_TITLE                   	independent of Trem2-mediated microglial activation
ST:STUDY_SUMMARY                 	This study investigated how sulfatide (ST) deficiency, an early lipid alteration
ST:STUDY_SUMMARY                 	in Alzheimer’s disease (AD), drives neuroinflammation and lipid
ST:STUDY_SUMMARY                 	dyshomeostasis, and whether these processes depend on Trem2-mediated microglial
ST:STUDY_SUMMARY                 	signaling. Using ST-deficient mice with or without Trem2 knockout, the
ST:STUDY_SUMMARY                 	researchers found that ST loss consistently caused myelin lipid disruption,
ST:STUDY_SUMMARY                 	cognitive impairment, free water retention, and bladder enlargement—phenotypes
ST:STUDY_SUMMARY                 	that were independent of Trem2 and more severe in females. Trem2 deficiency
ST:STUDY_SUMMARY                 	reduced some transcriptomic inflammatory responses but did not alter
ST:STUDY_SUMMARY                 	astrogliosis or lipid losses at the protein level, suggesting that Trem2
ST:STUDY_SUMMARY                 	primarily modulates microglial signaling but not astrocyte activation or lipid
ST:STUDY_SUMMARY                 	disruption. Overall, the findings highlight sulfatide deficiency as a key driver
ST:STUDY_SUMMARY                 	of lipid and glial imbalance, and suggest that preserving myelin lipid integrity
ST:STUDY_SUMMARY                 	and astrocyte balance may be more effective than solely targeting Trem2-mediated
ST:STUDY_SUMMARY                 	microglial activation in slowing AD progression.
ST:INSTITUTE                     	UT Health San Antonio
ST:LAST_NAME                     	Han
ST:FIRST_NAME                    	Xianlin
ST:ADDRESS                       	4939 Charles Katz Dr
ST:EMAIL                         	hanx@uthscsa.edu
ST:PHONE                         	2105624104
#SUBJECT
SU:SUBJECT_TYPE                  	Mammal
SU:SUBJECT_SPECIES               	Mus musculus
SU:TAXONOMY_ID                   	10090
#SUBJECT_SAMPLE_FACTORS:         	SUBJECT(optional)[tab]SAMPLE[tab]FACTORS(NAME:VALUE pairs separated by |)[tab]Raw file names and additional sample data
SUBJECT_SAMPLE_FACTORS           	-	Female_CRM_Cre-1	Sample source:mouse cerebrum | genotype:Cre-	RAW_FILE_NAME(raw file name)=CAR-1.raw, CER-1.raw, PC-1.raw, PE-1.raw, 1.raw
SUBJECT_SAMPLE_FACTORS           	-	Female_CRM_Cre-2	Sample source:mouse cerebrum | genotype:Cre-	RAW_FILE_NAME(raw file name)=CAR-2.raw, CER-2.raw, PC-2.raw, PE-2.raw, 2.raw
SUBJECT_SAMPLE_FACTORS           	-	Female_CRM_Cre-3	Sample source:mouse cerebrum | genotype:Cre-	RAW_FILE_NAME(raw file name)=CAR-3.raw, CER-3.raw, PC-3.raw, PE-3.raw, 3.raw
SUBJECT_SAMPLE_FACTORS           	-	Female_CRM_Cre-4	Sample source:mouse cerebrum | genotype:Cre-	RAW_FILE_NAME(raw file name)=CAR-4.raw, CER-4.raw, PC-4.raw, PE-4.raw, 4.raw
SUBJECT_SAMPLE_FACTORS           	-	Female_CRM_Cre-5	Sample source:mouse cerebrum | genotype:Cre-	RAW_FILE_NAME(raw file name)=CAR-5.raw, CER-5.raw, PC-5.raw, PE-5.raw, 5.raw
SUBJECT_SAMPLE_FACTORS           	-	Female_CRM_Cre-6	Sample source:mouse cerebrum | genotype:Cre-	RAW_FILE_NAME(raw file name)=CAR-6.raw, CER-6.raw, PC-6.raw, PE-6.raw, 6.raw
SUBJECT_SAMPLE_FACTORS           	-	Female_CRM_Cre+1	Sample source:mouse cerebrum | genotype:Cre+	RAW_FILE_NAME(raw file name)=CAR-7.raw, CER-7.raw, PC-7.raw, PE-7.raw, 7.raw
SUBJECT_SAMPLE_FACTORS           	-	Female_CRM_Cre+2	Sample source:mouse cerebrum | genotype:Cre+	RAW_FILE_NAME(raw file name)=CAR-8.raw, CER-8.raw, PC-8.raw, PE-8.raw, 8.raw
SUBJECT_SAMPLE_FACTORS           	-	Female_CRM_Cre+3	Sample source:mouse cerebrum | genotype:Cre+	RAW_FILE_NAME(raw file name)=CAR-9.raw, CER-9.raw, PC-9.raw, PE-9.raw, 9.raw
SUBJECT_SAMPLE_FACTORS           	-	Female_CRM_Cre+4	Sample source:mouse cerebrum | genotype:Cre+	RAW_FILE_NAME(raw file name)=CAR-10.raw, CER-10.raw, PC-10.raw, PE-10.raw, 10.raw
SUBJECT_SAMPLE_FACTORS           	-	Female_CRM_Cre+5	Sample source:mouse cerebrum | genotype:Cre+	RAW_FILE_NAME(raw file name)=CAR-11.raw, CER-11.raw, PC-11.raw, PE-11.raw, 11.raw
SUBJECT_SAMPLE_FACTORS           	-	Female_CRM_Cre+6	Sample source:mouse cerebrum | genotype:Cre+	RAW_FILE_NAME(raw file name)=CAR-12.raw, CER-12.raw, PC-12.raw, PE-12.raw, 12.raw
SUBJECT_SAMPLE_FACTORS           	-	Female_CRM_Cre+7	Sample source:mouse cerebrum | genotype:Cre+	RAW_FILE_NAME(raw file name)=CAR-13.raw, CER-13.raw, PC-13.raw, PE-13.raw, 13.raw
SUBJECT_SAMPLE_FACTORS           	-	Female_CRM_Trem2 KO/Cre-1	Sample source:mouse cerebrum | genotype:Trem2 KO/Cre-	RAW_FILE_NAME(raw file name)=CAR-14.raw, CER-14.raw, PC-14.raw, PE-14.raw, 14.raw
SUBJECT_SAMPLE_FACTORS           	-	Female_CRM_Trem2 KO/Cre-2	Sample source:mouse cerebrum | genotype:Trem2 KO/Cre-	RAW_FILE_NAME(raw file name)=CAR-15.raw, CER-15.raw, PC-15.raw, PE-15.raw, 15.raw
SUBJECT_SAMPLE_FACTORS           	-	Female_CRM_Trem2 KO/Cre-3	Sample source:mouse cerebrum | genotype:Trem2 KO/Cre-	RAW_FILE_NAME(raw file name)=CAR-16.raw, CER-16.raw, PC-16.raw, PE-16.raw, 16.raw
SUBJECT_SAMPLE_FACTORS           	-	Female_CRM_Trem2 KO/Cre-4	Sample source:mouse cerebrum | genotype:Trem2 KO/Cre-	RAW_FILE_NAME(raw file name)=CAR-17.raw, CER-17.raw, PC-17.raw, PE-17.raw, 17.raw
SUBJECT_SAMPLE_FACTORS           	-	Female_CRM_Trem2 KO/Cre-5	Sample source:mouse cerebrum | genotype:Trem2 KO/Cre-	RAW_FILE_NAME(raw file name)=CAR-18.raw, CER-18.raw, PC-18.raw, PE-18.raw, 18.raw
SUBJECT_SAMPLE_FACTORS           	-	Female_CRM_Trem2 KO/Cre+1	Sample source:mouse cerebrum | genotype:Trem2 KO/Cre+	RAW_FILE_NAME(raw file name)=CAR-19.raw, CER-19.raw, PC-19.raw, PE-19.raw, 19.raw
SUBJECT_SAMPLE_FACTORS           	-	Female_CRM_Trem2 KO/Cre+2	Sample source:mouse cerebrum | genotype:Trem2 KO/Cre+	RAW_FILE_NAME(raw file name)=CAR-20.raw, CER-20.raw, PC-20.raw, PE-20.raw, 20.raw
SUBJECT_SAMPLE_FACTORS           	-	Female_CRM_Trem2 KO/Cre+3	Sample source:mouse cerebrum | genotype:Trem2 KO/Cre+	RAW_FILE_NAME(raw file name)=CAR-21.raw, CER-21.raw, PC-21.raw, PE-21.raw, 21.raw
SUBJECT_SAMPLE_FACTORS           	-	Female_CRM_Trem2 KO/Cre+4	Sample source:mouse cerebrum | genotype:Trem2 KO/Cre+	RAW_FILE_NAME(raw file name)=CAR-22.raw, CER-22.raw, PC-22.raw, PE-22.raw, 22.raw
SUBJECT_SAMPLE_FACTORS           	-	Male_SC_Cre-1	Sample source:mouse spinal cord | genotype:Cre-	RAW_FILE_NAME(raw file name)=CAR-23.raw, CER-23.raw, PC-23.raw, PE-23.raw, 23.raw
SUBJECT_SAMPLE_FACTORS           	-	Male_SC_Cre-2	Sample source:mouse spinal cord | genotype:Cre-	RAW_FILE_NAME(raw file name)=CAR-24.raw, CER-24.raw, PC-24.raw, PE-24.raw, 24.raw
SUBJECT_SAMPLE_FACTORS           	-	Male_SC_Cre-3	Sample source:mouse spinal cord | genotype:Cre-	RAW_FILE_NAME(raw file name)=CAR-25.raw, CER-25.raw, PC-25.raw, PE-25.raw, 25.raw
SUBJECT_SAMPLE_FACTORS           	-	Male_SC_Cre-4	Sample source:mouse spinal cord | genotype:Cre-	RAW_FILE_NAME(raw file name)=CAR-26.raw, CER-26.raw, PC-26.raw, PE-26.raw, 26.raw
SUBJECT_SAMPLE_FACTORS           	-	Male_SC_Cre-5	Sample source:mouse spinal cord | genotype:Cre-	RAW_FILE_NAME(raw file name)=CAR-27.raw, CER-27.raw, PC-27.raw, PE-27.raw, 27.raw
SUBJECT_SAMPLE_FACTORS           	-	Male_SC_Cre-6	Sample source:mouse spinal cord | genotype:Cre-	RAW_FILE_NAME(raw file name)=CAR-28.raw, CER-28.raw, PC-28.raw, PE-28.raw, 28.raw
SUBJECT_SAMPLE_FACTORS           	-	Male_SC_Cre-7	Sample source:mouse spinal cord | genotype:Cre-	RAW_FILE_NAME(raw file name)=CAR-29.raw, CER-29.raw, PC-29.raw, PE-29.raw, 29.raw
SUBJECT_SAMPLE_FACTORS           	-	Male_SC_Cre-8	Sample source:mouse spinal cord | genotype:Cre-	RAW_FILE_NAME(raw file name)=CAR-30.raw, CER-30.raw, PC-30.raw, PE-30.raw, 30.raw
SUBJECT_SAMPLE_FACTORS           	-	Male_SC_Cre-9	Sample source:mouse spinal cord | genotype:Cre-	RAW_FILE_NAME(raw file name)=CAR-31.raw, CER-31.raw, PC-31.raw, PE-31.raw, 31.raw
SUBJECT_SAMPLE_FACTORS           	-	Male_SC_Cre+1	Sample source:mouse spinal cord | genotype:Cre+	RAW_FILE_NAME(raw file name)=CAR-32.raw, CER-32.raw, PC-32.raw, PE-32.raw, 32.raw
SUBJECT_SAMPLE_FACTORS           	-	Male_SC_Cre+2	Sample source:mouse spinal cord | genotype:Cre+	RAW_FILE_NAME(raw file name)=CAR-33.raw, CER-33.raw, PC-33.raw, PE-33.raw, 33.raw
SUBJECT_SAMPLE_FACTORS           	-	Male_SC_Cre+3	Sample source:mouse spinal cord | genotype:Cre+	RAW_FILE_NAME(raw file name)=CAR-34.raw, CER-34.raw, PC-34.raw, PE-34.raw, 34.raw
SUBJECT_SAMPLE_FACTORS           	-	Male_SC_Cre+4	Sample source:mouse spinal cord | genotype:Cre+	RAW_FILE_NAME(raw file name)=CAR-35.raw, CER-35.raw, PC-35.raw, PE-35.raw, 35.raw
SUBJECT_SAMPLE_FACTORS           	-	Male_SC_Cre+5	Sample source:mouse spinal cord | genotype:Cre+	RAW_FILE_NAME(raw file name)=CAR-36.raw, CER-36.raw, PC-36.raw, PE-36.raw, 36.raw
SUBJECT_SAMPLE_FACTORS           	-	Male_SC_Cre+6	Sample source:mouse spinal cord | genotype:Cre+	RAW_FILE_NAME(raw file name)=CAR-37.raw, CER-37.raw, PC-37.raw, PE-37.raw, 37.raw
SUBJECT_SAMPLE_FACTORS           	-	Male_SC_Cre+7	Sample source:mouse spinal cord | genotype:Cre+	RAW_FILE_NAME(raw file name)=CAR-38.raw, CER-38.raw, PC-38.raw, PE-38.raw, 38.raw
SUBJECT_SAMPLE_FACTORS           	-	Male_SC_Cre+8	Sample source:mouse spinal cord | genotype:Cre+	RAW_FILE_NAME(raw file name)=CAR-39.raw, CER-39.raw, PC-39.raw, PE-39.raw, 39.raw
SUBJECT_SAMPLE_FACTORS           	-	Male_SC_Cre+9	Sample source:mouse spinal cord | genotype:Cre+	RAW_FILE_NAME(raw file name)=CAR-40.raw, CER-40.raw, PC-40.raw, PE-40.raw, 40.raw
SUBJECT_SAMPLE_FACTORS           	-	Male_SC_Trem2 KO/Cre-1	Sample source:mouse spinal cord | genotype:Trem2 KO/Cre-	RAW_FILE_NAME(raw file name)=CAR-41.raw, CER-41.raw, PC-41.raw, PE-41.raw, 41.raw
SUBJECT_SAMPLE_FACTORS           	-	Male_SC_Trem2 KO/Cre-2	Sample source:mouse spinal cord | genotype:Trem2 KO/Cre-	RAW_FILE_NAME(raw file name)=CAR-42.raw, CER-42.raw, PC-42.raw, PE-42.raw, 42.raw
SUBJECT_SAMPLE_FACTORS           	-	Male_SC_Trem2 KO/Cre-3	Sample source:mouse spinal cord | genotype:Trem2 KO/Cre-	RAW_FILE_NAME(raw file name)=CAR-43.raw, CER-43.raw, PC-43.raw, PE-43.raw, 43.raw
SUBJECT_SAMPLE_FACTORS           	-	Male_SC_Trem2 KO/Cre-4	Sample source:mouse spinal cord | genotype:Trem2 KO/Cre-	RAW_FILE_NAME(raw file name)=CAR-44.raw, CER-44.raw, PC-44.raw, PE-44.raw, 44.raw
SUBJECT_SAMPLE_FACTORS           	-	Male_SC_Trem2 KO/Cre-5	Sample source:mouse spinal cord | genotype:Trem2 KO/Cre-	RAW_FILE_NAME(raw file name)=CAR-45.raw, CER-45.raw, PC-45.raw, PE-45.raw, 45.raw
SUBJECT_SAMPLE_FACTORS           	-	Male_SC_Trem2 KO/Cre-6	Sample source:mouse spinal cord | genotype:Trem2 KO/Cre-	RAW_FILE_NAME(raw file name)=CAR-46.raw, CER-46.raw, PC-46.raw, PE-46.raw, 46.raw
SUBJECT_SAMPLE_FACTORS           	-	Male_SC_Trem2 KO/Cre-7	Sample source:mouse spinal cord | genotype:Trem2 KO/Cre-	RAW_FILE_NAME(raw file name)=CAR-47.raw, CER-47.raw, PC-47.raw, PE-47.raw, 47.raw
SUBJECT_SAMPLE_FACTORS           	-	Male_SC_Trem2 KO/Cre-8	Sample source:mouse spinal cord | genotype:Trem2 KO/Cre-	RAW_FILE_NAME(raw file name)=CAR-48.raw, CER-48.raw, PC-48.raw, PE-48.raw, 48.raw
SUBJECT_SAMPLE_FACTORS           	-	Male_SC_Trem2 KO/Cre-9	Sample source:mouse spinal cord | genotype:Trem2 KO/Cre-	RAW_FILE_NAME(raw file name)=CAR-49.raw, CER-49.raw, PC-49.raw, PE-49.raw, 49.raw
SUBJECT_SAMPLE_FACTORS           	-	Male_SC_Trem2 KO/Cre-10	Sample source:mouse spinal cord | genotype:Trem2 KO/Cre-	RAW_FILE_NAME(raw file name)=CAR-50.raw, CER-50.raw, PC-50.raw, PE-50.raw, 50.raw
SUBJECT_SAMPLE_FACTORS           	-	Male_SC_Trem2 KO/Cre+1	Sample source:mouse spinal cord | genotype:Trem2 KO/Cre+	RAW_FILE_NAME(raw file name)=CAR-51.raw, CER-51.raw, PC-51.raw, PE-51.raw, 51.raw
SUBJECT_SAMPLE_FACTORS           	-	Male_SC_Trem2 KO/Cre+2	Sample source:mouse spinal cord | genotype:Trem2 KO/Cre+	RAW_FILE_NAME(raw file name)=CAR-52.raw, CER-52.raw, PC-52.raw, PE-52.raw, 52.raw
SUBJECT_SAMPLE_FACTORS           	-	Male_SC_Trem2 KO/Cre+3	Sample source:mouse spinal cord | genotype:Trem2 KO/Cre+	RAW_FILE_NAME(raw file name)=CAR-53.raw, CER-53.raw, PC-53.raw, PE-53.raw, 53.raw
SUBJECT_SAMPLE_FACTORS           	-	Male_SC_Trem2 KO/Cre+4	Sample source:mouse spinal cord | genotype:Trem2 KO/Cre+	RAW_FILE_NAME(raw file name)=CAR-54.raw, CER-54.raw, PC-54.raw, PE-54.raw, 54.raw
SUBJECT_SAMPLE_FACTORS           	-	Male_SC_Trem2 KO/Cre+5	Sample source:mouse spinal cord | genotype:Trem2 KO/Cre+	RAW_FILE_NAME(raw file name)=CAR-55.raw, CER-55.raw, PC-55.raw, PE-55.raw, 55.raw
SUBJECT_SAMPLE_FACTORS           	-	Male_SC_Trem2 KO/Cre+6	Sample source:mouse spinal cord | genotype:Trem2 KO/Cre+	RAW_FILE_NAME(raw file name)=CAR-56.raw, CER-56.raw, PC-56.raw, PE-56.raw, 56.raw
SUBJECT_SAMPLE_FACTORS           	-	Male_SC_Trem2 KO/Cre+7	Sample source:mouse spinal cord | genotype:Trem2 KO/Cre+	RAW_FILE_NAME(raw file name)=CAR-57.raw, CER-57.raw, PC-57.raw, PE-57.raw, 57.raw
SUBJECT_SAMPLE_FACTORS           	-	Male_SC_Trem2 KO/Cre+8	Sample source:mouse spinal cord | genotype:Trem2 KO/Cre+	RAW_FILE_NAME(raw file name)=CAR-58.raw, CER-58.raw, PC-58.raw, PE-58.raw, 58.raw
SUBJECT_SAMPLE_FACTORS           	-	Male_SC_Trem2 KO/Cre+9	Sample source:mouse spinal cord | genotype:Trem2 KO/Cre+	RAW_FILE_NAME(raw file name)=CAR-59.raw, CER-59.raw, PC-59.raw, PE-59.raw, 59.raw
SUBJECT_SAMPLE_FACTORS           	-	Male_SC_Trem2 KO/Cre+10	Sample source:mouse spinal cord | genotype:Trem2 KO/Cre+	RAW_FILE_NAME(raw file name)=CAR-60.raw, CER-60.raw, PC-60.raw, PE-60.raw, 60.raw
SUBJECT_SAMPLE_FACTORS           	-	Male_SC_Trem2 KO/Cre+11	Sample source:mouse spinal cord | genotype:Trem2 KO/Cre+	RAW_FILE_NAME(raw file name)=CAR-61.raw, CER-61.raw, PC-61.raw, PE-61.raw, 61.raw
SUBJECT_SAMPLE_FACTORS           	-	Male_SC_Trem2 KO/Cre+12	Sample source:mouse spinal cord | genotype:Trem2 KO/Cre+	RAW_FILE_NAME(raw file name)=CAR-62.raw, CER-62.raw, PC-62.raw, PE-62.raw, 62.raw
SUBJECT_SAMPLE_FACTORS           	-	Male_SC_Trem2 KO/Cre+13	Sample source:mouse spinal cord | genotype:Trem2 KO/Cre+	RAW_FILE_NAME(raw file name)=CAR-63.raw, CER-63.raw, PC-63.raw, PE-63.raw, 63.raw
SUBJECT_SAMPLE_FACTORS           	-	Male_SC_Trem2 KO/Cre+14	Sample source:mouse spinal cord | genotype:Trem2 KO/Cre+	RAW_FILE_NAME(raw file name)=CAR-64.raw, CER-64.raw, PC-64.raw, PE-64.raw, 64.raw
SUBJECT_SAMPLE_FACTORS           	-	Female_SC_Cre-1	Sample source:mouse spinal cord | genotype:Cre-	RAW_FILE_NAME(raw file name)=CAR-65.raw, CER-65.raw, PC-65.raw, PE-65.raw, 65.raw
SUBJECT_SAMPLE_FACTORS           	-	Female_SC_Cre-2	Sample source:mouse spinal cord | genotype:Cre-	RAW_FILE_NAME(raw file name)=CAR-66.raw, CER-66.raw, PC-66.raw, PE-66.raw, 66.raw
SUBJECT_SAMPLE_FACTORS           	-	Female_SC_Cre-3	Sample source:mouse spinal cord | genotype:Cre-	RAW_FILE_NAME(raw file name)=CAR-67.raw, CER-67.raw, PC-67.raw, PE-67.raw, 67.raw
SUBJECT_SAMPLE_FACTORS           	-	Female_SC_Cre-4	Sample source:mouse spinal cord | genotype:Cre-	RAW_FILE_NAME(raw file name)=CAR-68.raw, CER-68.raw, PC-68.raw, PE-68.raw, 68.raw
SUBJECT_SAMPLE_FACTORS           	-	Female_SC_Cre-5	Sample source:mouse spinal cord | genotype:Cre-	RAW_FILE_NAME(raw file name)=CAR-69.raw, CER-69.raw, PC-69.raw, PE-69.raw, 69.raw
SUBJECT_SAMPLE_FACTORS           	-	Female_SC_Cre-6	Sample source:mouse spinal cord | genotype:Cre-	RAW_FILE_NAME(raw file name)=CAR-70.raw, CER-70.raw, PC-70.raw, PE-70.raw, 70.raw
SUBJECT_SAMPLE_FACTORS           	-	Female_SC_Cre-7	Sample source:mouse spinal cord | genotype:Cre-	RAW_FILE_NAME(raw file name)=CAR-71.raw, CER-71.raw, PC-71.raw, PE-71.raw, 71.raw
SUBJECT_SAMPLE_FACTORS           	-	Female_SC_Cre-8	Sample source:mouse spinal cord | genotype:Cre-	RAW_FILE_NAME(raw file name)=CAR-72.raw, CER-72.raw, PC-72.raw, PE-72.raw, 72.raw
SUBJECT_SAMPLE_FACTORS           	-	Female_SC_Cre-9	Sample source:mouse spinal cord | genotype:Cre-	RAW_FILE_NAME(raw file name)=CAR-73.raw, CER-73.raw, PC-73.raw, PE-73.raw, 73.raw
SUBJECT_SAMPLE_FACTORS           	-	Female_SC_Cre-10	Sample source:mouse spinal cord | genotype:Cre-	RAW_FILE_NAME(raw file name)=CAR-74.raw, CER-74.raw, PC-74.raw, PE-74.raw, 74.raw
SUBJECT_SAMPLE_FACTORS           	-	Female_SC_Cre+1	Sample source:mouse spinal cord | genotype:Cre+	RAW_FILE_NAME(raw file name)=CAR-75.raw, CER-75.raw, PC-75.raw, PE-75.raw, 75.raw
SUBJECT_SAMPLE_FACTORS           	-	Female_SC_Cre+2	Sample source:mouse spinal cord | genotype:Cre+	RAW_FILE_NAME(raw file name)=CAR-76.raw, CER-76.raw, PC-76.raw, PE-76.raw, 76.raw
SUBJECT_SAMPLE_FACTORS           	-	Female_SC_Cre+3	Sample source:mouse spinal cord | genotype:Cre+	RAW_FILE_NAME(raw file name)=CAR-77.raw, CER-77.raw, PC-77.raw, PE-77.raw, 77.raw
SUBJECT_SAMPLE_FACTORS           	-	Female_SC_Cre+4	Sample source:mouse spinal cord | genotype:Cre+	RAW_FILE_NAME(raw file name)=CAR-78.raw, CER-78.raw, PC-78.raw, PE-78.raw, 78.raw
SUBJECT_SAMPLE_FACTORS           	-	Female_SC_Cre+5	Sample source:mouse spinal cord | genotype:Cre+	RAW_FILE_NAME(raw file name)=CAR-79.raw, CER-79.raw, PC-79.raw, PE-79.raw, 79.raw
SUBJECT_SAMPLE_FACTORS           	-	Female_SC_Cre+6	Sample source:mouse spinal cord | genotype:Cre+	RAW_FILE_NAME(raw file name)=CAR-80.raw, CER-80.raw, PC-80.raw, PE-80.raw, 80.raw
SUBJECT_SAMPLE_FACTORS           	-	Female_SC_Cre+7	Sample source:mouse spinal cord | genotype:Cre+	RAW_FILE_NAME(raw file name)=CAR-81.raw, CER-81.raw, PC-81.raw, PE-81.raw, 81.raw
SUBJECT_SAMPLE_FACTORS           	-	Female_SC_Cre+8	Sample source:mouse spinal cord | genotype:Cre+	RAW_FILE_NAME(raw file name)=CAR-82.raw, CER-82.raw, PC-82.raw, PE-82.raw, 82.raw
SUBJECT_SAMPLE_FACTORS           	-	Female_SC_Cre+9	Sample source:mouse spinal cord | genotype:Cre+	RAW_FILE_NAME(raw file name)=CAR-83.raw, CER-83.raw, PC-83.raw, PE-83.raw, 83.raw
SUBJECT_SAMPLE_FACTORS           	-	Female_SC_Cre+10	Sample source:mouse spinal cord | genotype:Cre+	RAW_FILE_NAME(raw file name)=CAR-84.raw, CER-84.raw, PC-84.raw, PE-84.raw, 84.raw
SUBJECT_SAMPLE_FACTORS           	-	Female_SC_Cre+11	Sample source:mouse spinal cord | genotype:Cre+	RAW_FILE_NAME(raw file name)=CAR-85.raw, CER-85.raw, PC-85.raw, PE-85.raw, 85.raw
SUBJECT_SAMPLE_FACTORS           	-	Female_SC_Cre+12	Sample source:mouse spinal cord | genotype:Cre+	RAW_FILE_NAME(raw file name)=CAR-86.raw, CER-86.raw, PC-86.raw, PE-86.raw, 86.raw
SUBJECT_SAMPLE_FACTORS           	-	Female_SC_Trem2 KO/Cre-1	Sample source:mouse spinal cord | genotype:Trem2 KO/Cre-	RAW_FILE_NAME(raw file name)=CAR-87.raw, CER-87.raw, PC-87.raw, PE-87.raw, 87.raw
SUBJECT_SAMPLE_FACTORS           	-	Female_SC_Trem2 KO/Cre-2	Sample source:mouse spinal cord | genotype:Trem2 KO/Cre-	RAW_FILE_NAME(raw file name)=CAR-88.raw, CER-88.raw, PC-88.raw, PE-88.raw, 88.raw
SUBJECT_SAMPLE_FACTORS           	-	Female_SC_Trem2 KO/Cre-3	Sample source:mouse spinal cord | genotype:Trem2 KO/Cre-	RAW_FILE_NAME(raw file name)=CAR-89.raw, CER-89.raw, PC-89.raw, PE-89.raw, 89.raw
SUBJECT_SAMPLE_FACTORS           	-	Female_SC_Trem2 KO/Cre-4	Sample source:mouse spinal cord | genotype:Trem2 KO/Cre-	RAW_FILE_NAME(raw file name)=CAR-90.raw, CER-90.raw, PC-90.raw, PE-90.raw, 90.raw
SUBJECT_SAMPLE_FACTORS           	-	Female_SC_Trem2 KO/Cre-5	Sample source:mouse spinal cord | genotype:Trem2 KO/Cre-	RAW_FILE_NAME(raw file name)=CAR-91.raw, CER-91.raw, PC-91.raw, PE-91.raw, 91.raw
SUBJECT_SAMPLE_FACTORS           	-	Female_SC_Trem2 KO/Cre-6	Sample source:mouse spinal cord | genotype:Trem2 KO/Cre-	RAW_FILE_NAME(raw file name)=CAR-92.raw, CER-92.raw, PC-92.raw, PE-92.raw, 92.raw
SUBJECT_SAMPLE_FACTORS           	-	Female_SC_Trem2 KO/Cre-7	Sample source:mouse spinal cord | genotype:Trem2 KO/Cre-	RAW_FILE_NAME(raw file name)=CAR-93.raw, CER-93.raw, PC-93.raw, PE-93.raw, 93.raw
SUBJECT_SAMPLE_FACTORS           	-	Female_SC_Trem2 KO/Cre-8	Sample source:mouse spinal cord | genotype:Trem2 KO/Cre-	RAW_FILE_NAME(raw file name)=CAR-94.raw, CER-94.raw, PC-94.raw, PE-94.raw, 94.raw
SUBJECT_SAMPLE_FACTORS           	-	Female_SC_Trem2 KO/Cre+1	Sample source:mouse spinal cord | genotype:Trem2 KO/Cre+	RAW_FILE_NAME(raw file name)=CAR-95.raw, CER-95.raw, PC-95.raw, PE-95.raw, 95.raw
SUBJECT_SAMPLE_FACTORS           	-	Female_SC_Trem2 KO/Cre+2	Sample source:mouse spinal cord | genotype:Trem2 KO/Cre+	RAW_FILE_NAME(raw file name)=CAR-96.raw, CER-96.raw, PC-96.raw, PE-96.raw, 96.raw
SUBJECT_SAMPLE_FACTORS           	-	Female_SC_Trem2 KO/Cre+3	Sample source:mouse spinal cord | genotype:Trem2 KO/Cre+	RAW_FILE_NAME(raw file name)=CAR-97.raw, CER-97.raw, PC-97.raw, PE-97.raw, 97.raw
SUBJECT_SAMPLE_FACTORS           	-	Female_SC_Trem2 KO/Cre+4	Sample source:mouse spinal cord | genotype:Trem2 KO/Cre+	RAW_FILE_NAME(raw file name)=CAR-98.raw, CER-98.raw, PC-98.raw, PE-98.raw, 98.raw
SUBJECT_SAMPLE_FACTORS           	-	Female_SC_Trem2 KO/Cre+5	Sample source:mouse spinal cord | genotype:Trem2 KO/Cre+	RAW_FILE_NAME(raw file name)=CAR-99.raw, CER-99.raw, PC-99.raw, PE-99.raw, 99.raw
SUBJECT_SAMPLE_FACTORS           	-	Female_SC_Trem2 KO/Cre+6	Sample source:mouse spinal cord | genotype:Trem2 KO/Cre+	RAW_FILE_NAME(raw file name)=CAR-100.raw, CER-100.raw, PC-100.raw, PE-100.raw, 100.raw
SUBJECT_SAMPLE_FACTORS           	-	Female_SC_Trem2 KO/Cre+7	Sample source:mouse spinal cord | genotype:Trem2 KO/Cre+	RAW_FILE_NAME(raw file name)=CAR-101.raw, CER-101.raw, PC-101.raw, PE-101.raw, 101.raw
#COLLECTION
CO:COLLECTION_SUMMARY            	Animal experiments were conducted in accordance with the ‘Guide for the Care
CO:COLLECTION_SUMMARY            	and Use of Laboratory Animals’ (8th edition, National Research Council of the
CO:COLLECTION_SUMMARY            	National Academies, 2011). The animal protocol was approved by the Institutional
CO:COLLECTION_SUMMARY            	Animal Care and Use Committee (protocol code 20180044AP and approved on
CO:COLLECTION_SUMMARY            	01-09-2019). Cerebrum (from the right hemisphere) and spinal cord tissues were
CO:COLLECTION_SUMMARY            	collected immediately after dissection. Tissues were visually inspected to
CO:COLLECTION_SUMMARY            	exclude any samples with obvious signs of damage. Only intact, grossly
CO:COLLECTION_SUMMARY            	normal-appearing specimens were included in the study. Each specimen was rapidly
CO:COLLECTION_SUMMARY            	snap-frozen in liquid nitrogen and stored at –80 °C until further use.
CO:SAMPLE_TYPE                   	Brain
#TREATMENT
TR:TREATMENT_SUMMARY             	The CST fl/fl mice were generated by Applied Stem Cell, Inc. using CRISPR
TR:TREATMENT_SUMMARY             	technology to inject C57BL/6 embryos as previously described [1]. The
TR:TREATMENT_SUMMARY             	Plp1-CreERT and Trem2 KO mouse lines were both purchased from JAX (stock #005975
TR:TREATMENT_SUMMARY             	and #027197, respectively). The CST fl/fl mice were crossed with Plp1-CreERT+
TR:TREATMENT_SUMMARY             	mice to generate conditional ST-deficient (Cre+) mice along with their
TR:TREATMENT_SUMMARY             	respective (Cre-) controls as previously described. The constitutive Trem2 KO
TR:TREATMENT_SUMMARY             	mice were crossed with ST-deficient Cre+ mice to generate Trem2 KO deficient
TR:TREATMENT_SUMMARY             	mice (Trem2, CST fl/fl/Plp1-CreERT+) denoted as (KO/Cre+) along with the control
TR:TREATMENT_SUMMARY             	(KO/Cre-).  [1] Qiu, S. et al. Adult-onset CNS myelin sulfatide deficiency is
TR:TREATMENT_SUMMARY             	sufficient to cause Alzheimer's disease-like neuroinflammation and cognitive
TR:TREATMENT_SUMMARY             	impairment. Mol Neurodegener 16, 64 (2021).
#SAMPLEPREP
SP:SAMPLEPREP_SUMMARY            	Pulverized frozen CRM and SC tissues were homogenized ice-cold
SP:SAMPLEPREP_SUMMARY            	phosphate-buffered saline using a Precellys® Evolution Tissue Homogenizer
SP:SAMPLEPREP_SUMMARY            	(Bertin, France). The protein concentration of homogenates was determined using
SP:SAMPLEPREP_SUMMARY            	the Pierce BCA Protein Assay Kit (Thermo Fisher Scientific) following the
SP:SAMPLEPREP_SUMMARY            	manufacturer’s protocol. Lipids were extracted by the modified procedure of
SP:SAMPLEPREP_SUMMARY            	Bligh and Dyer in the presence of internal standards that were added based on
SP:SAMPLEPREP_SUMMARY            	the total protein content of each sample.
#CHROMATOGRAPHY
CH:CHROMATOGRAPHY_TYPE           	None (Direct infusion)
CH:INSTRUMENT_NAME               	none
CH:COLUMN_NAME                   	none
CH:SOLVENT_A                     	NA
CH:SOLVENT_B                     	NA
CH:FLOW_GRADIENT                 	NA
CH:FLOW_RATE                     	NA
CH:COLUMN_TEMPERATURE            	NA
#ANALYSIS
AN:ANALYSIS_TYPE                 	MS
#MS
MS:INSTRUMENT_NAME               	Thermo TSQ Altis
MS:INSTRUMENT_TYPE               	Triple quadrupole
MS:MS_TYPE                       	ESI
MS:ION_MODE                      	NEGATIVE
MS:MS_COMMENTS                   	Mass spectrometric analysis was performed on a triple quadrupole mass
MS:MS_COMMENTS                   	spectrometer (TSQ Altis, Thermo Fisher Scientific, SanJose, CA), which is
MS:MS_COMMENTS                   	equipped with an automated nanospray device (TriVersa NanoMate, Advion
MS:MS_COMMENTS                   	Bioscience Ltd., Ithaca, NY) asdescribed [1]. Identification and quantification
MS:MS_COMMENTS                   	of lipid species were performed using an automated software program [2, 3].
MS:MS_COMMENTS                   	Inshotgun lipidomics, the terms positive mode and negative mode refer to the
MS:MS_COMMENTS                   	polarity of ionization used during electrosprayionization (ESI), which directly
MS:MS_COMMENTS                   	influences the types of lipids detected and how well they are characterized.
MS:MS_COMMENTS                   	Negative ion modegenerates negatively charged ions and is optimal for detecting
MS:MS_COMMENTS                   	anionic lipids, such as PE and Cer in this study. Data processing (e.g., ion
MS:MS_COMMENTS                   	peakselection, baseline correction, data transfer, peak intensity comparison and
MS:MS_COMMENTS                   	quantitation) was performed as described [3]. [1] Han,X., K. Yang, and R.W.
MS:MS_COMMENTS                   	Gross, Microfluidics-based electrospray ionization enhances the intrasource
MS:MS_COMMENTS                   	separation of lipid classes andextends identification of individual molecular
MS:MS_COMMENTS                   	species through multi-dimensional mass spectrometry: development of an
MS:MS_COMMENTS                   	automatedhigh-throughput platform for shotgun lipidomics. Rapid Commun Mass
MS:MS_COMMENTS                   	Spectrom, 2008. 22(13): p. 2115-24. [2] Wang, M., et al.,Novel advances in
MS:MS_COMMENTS                   	shotgun lipidomics for biology and medicine. Prog Lipid Res, 2016. 61: p.
MS:MS_COMMENTS                   	83-108. [3] Yang, K., et al., Automatedlipid identification and quantification
MS:MS_COMMENTS                   	by multidimensional mass spectrometry-based shotgun lipidomics. Anal Chem, 2009.
MS:MS_COMMENTS                   	81(11):p. 4356-68. (NOTE: Associated raw data files are PE-1~101, CER-1~101)
#MS_METABOLITE_DATA
MS_METABOLITE_DATA:UNITS	nmol/mg protein
MS_METABOLITE_DATA_START
Samples	Female_CRM_Cre-1	Female_CRM_Cre-2	Female_CRM_Cre-3	Female_CRM_Cre-4	Female_CRM_Cre-5	Female_CRM_Cre-6	Female_CRM_Cre+1	Female_CRM_Cre+2	Female_CRM_Cre+3	Female_CRM_Cre+4	Female_CRM_Cre+5	Female_CRM_Cre+6	Female_CRM_Cre+7	Female_CRM_Trem2 KO/Cre-1	Female_CRM_Trem2 KO/Cre-2	Female_CRM_Trem2 KO/Cre-3	Female_CRM_Trem2 KO/Cre-4	Female_CRM_Trem2 KO/Cre-5	Female_CRM_Trem2 KO/Cre+1	Female_CRM_Trem2 KO/Cre+2	Female_CRM_Trem2 KO/Cre+3	Female_CRM_Trem2 KO/Cre+4	Male_SC_Cre-1	Male_SC_Cre-2	Male_SC_Cre-3	Male_SC_Cre-4	Male_SC_Cre-5	Male_SC_Cre-6	Male_SC_Cre-7	Male_SC_Cre-8	Male_SC_Cre-9	Male_SC_Cre+1	Male_SC_Cre+2	Male_SC_Cre+3	Male_SC_Cre+4	Male_SC_Cre+5	Male_SC_Cre+6	Male_SC_Cre+7	Male_SC_Cre+8	Male_SC_Cre+9	Male_SC_Trem2 KO/Cre-1	Male_SC_Trem2 KO/Cre-2	Male_SC_Trem2 KO/Cre-3	Male_SC_Trem2 KO/Cre-4	Male_SC_Trem2 KO/Cre-5	Male_SC_Trem2 KO/Cre-6	Male_SC_Trem2 KO/Cre-7	Male_SC_Trem2 KO/Cre-8	Male_SC_Trem2 KO/Cre-9	Male_SC_Trem2 KO/Cre-10	Male_SC_Trem2 KO/Cre+1	Male_SC_Trem2 KO/Cre+2	Male_SC_Trem2 KO/Cre+3	Male_SC_Trem2 KO/Cre+4	Male_SC_Trem2 KO/Cre+5	Male_SC_Trem2 KO/Cre+6	Male_SC_Trem2 KO/Cre+7	Male_SC_Trem2 KO/Cre+8	Male_SC_Trem2 KO/Cre+9	Male_SC_Trem2 KO/Cre+10	Male_SC_Trem2 KO/Cre+11	Male_SC_Trem2 KO/Cre+12	Male_SC_Trem2 KO/Cre+13	Male_SC_Trem2 KO/Cre+14	Female_SC_Cre-1	Female_SC_Cre-2	Female_SC_Cre-3	Female_SC_Cre-4	Female_SC_Cre-5	Female_SC_Cre-6	Female_SC_Cre-7	Female_SC_Cre-8	Female_SC_Cre-9	Female_SC_Cre-10	Female_SC_Cre+1	Female_SC_Cre+2	Female_SC_Cre+3	Female_SC_Cre+4	Female_SC_Cre+5	Female_SC_Cre+6	Female_SC_Cre+7	Female_SC_Cre+8	Female_SC_Cre+9	Female_SC_Cre+10	Female_SC_Cre+11	Female_SC_Cre+12	Female_SC_Trem2 KO/Cre-1	Female_SC_Trem2 KO/Cre-2	Female_SC_Trem2 KO/Cre-3	Female_SC_Trem2 KO/Cre-4	Female_SC_Trem2 KO/Cre-5	Female_SC_Trem2 KO/Cre-6	Female_SC_Trem2 KO/Cre-7	Female_SC_Trem2 KO/Cre-8	Female_SC_Trem2 KO/Cre+1	Female_SC_Trem2 KO/Cre+2	Female_SC_Trem2 KO/Cre+3	Female_SC_Trem2 KO/Cre+4	Female_SC_Trem2 KO/Cre+5	Female_SC_Trem2 KO/Cre+6	Female_SC_Trem2 KO/Cre+7
Factors	Sample source:mouse cerebrum | genotype:Cre-	Sample source:mouse cerebrum | genotype:Cre-	Sample source:mouse cerebrum | genotype:Cre-	Sample source:mouse cerebrum | genotype:Cre-	Sample source:mouse cerebrum | genotype:Cre-	Sample source:mouse cerebrum | genotype:Cre-	Sample source:mouse cerebrum | genotype:Cre+	Sample source:mouse cerebrum | genotype:Cre+	Sample source:mouse cerebrum | genotype:Cre+	Sample source:mouse cerebrum | genotype:Cre+	Sample source:mouse cerebrum | genotype:Cre+	Sample source:mouse cerebrum | genotype:Cre+	Sample source:mouse cerebrum | genotype:Cre+	Sample source:mouse cerebrum | genotype:Trem2 KO/Cre-	Sample source:mouse cerebrum | genotype:Trem2 KO/Cre-	Sample source:mouse cerebrum | genotype:Trem2 KO/Cre-	Sample source:mouse cerebrum | genotype:Trem2 KO/Cre-	Sample source:mouse cerebrum | genotype:Trem2 KO/Cre-	Sample source:mouse cerebrum | genotype:Trem2 KO/Cre+	Sample source:mouse cerebrum | genotype:Trem2 KO/Cre+	Sample source:mouse cerebrum | genotype:Trem2 KO/Cre+	Sample source:mouse cerebrum | genotype:Trem2 KO/Cre+	Sample source:mouse spinal cord | genotype:Cre-	Sample source:mouse spinal cord | genotype:Cre-	Sample source:mouse spinal cord | genotype:Cre-	Sample source:mouse spinal cord | genotype:Cre-	Sample source:mouse spinal cord | genotype:Cre-	Sample source:mouse spinal cord | genotype:Cre-	Sample source:mouse spinal cord | genotype:Cre-	Sample source:mouse spinal cord | genotype:Cre-	Sample source:mouse spinal cord | genotype:Cre-	Sample source:mouse spinal cord | genotype:Cre+	Sample source:mouse spinal cord | genotype:Cre+	Sample source:mouse spinal cord | genotype:Cre+	Sample source:mouse spinal cord | genotype:Cre+	Sample source:mouse spinal cord | genotype:Cre+	Sample source:mouse spinal cord | genotype:Cre+	Sample source:mouse spinal cord | genotype:Cre+	Sample source:mouse spinal cord | genotype:Cre+	Sample source:mouse spinal cord | genotype:Cre+	Sample source:mouse spinal cord | genotype:Trem2 KO/Cre-	Sample source:mouse spinal cord | genotype:Trem2 KO/Cre-	Sample source:mouse spinal cord | genotype:Trem2 KO/Cre-	Sample source:mouse spinal cord | genotype:Trem2 KO/Cre-	Sample source:mouse spinal cord | genotype:Trem2 KO/Cre-	Sample source:mouse spinal cord | genotype:Trem2 KO/Cre-	Sample source:mouse spinal cord | genotype:Trem2 KO/Cre-	Sample source:mouse spinal cord | genotype:Trem2 KO/Cre-	Sample source:mouse spinal cord | genotype:Trem2 KO/Cre-	Sample source:mouse spinal cord | genotype:Trem2 KO/Cre-	Sample source:mouse spinal cord | genotype:Trem2 KO/Cre+	Sample source:mouse spinal cord | genotype:Trem2 KO/Cre+	Sample source:mouse spinal cord | genotype:Trem2 KO/Cre+	Sample source:mouse spinal cord | genotype:Trem2 KO/Cre+	Sample source:mouse spinal cord | genotype:Trem2 KO/Cre+	Sample source:mouse spinal cord | genotype:Trem2 KO/Cre+	Sample source:mouse spinal cord | genotype:Trem2 KO/Cre+	Sample source:mouse spinal cord | genotype:Trem2 KO/Cre+	Sample source:mouse spinal cord | genotype:Trem2 KO/Cre+	Sample source:mouse spinal cord | genotype:Trem2 KO/Cre+	Sample source:mouse spinal cord | genotype:Trem2 KO/Cre+	Sample source:mouse spinal cord | genotype:Trem2 KO/Cre+	Sample source:mouse spinal cord | genotype:Trem2 KO/Cre+	Sample source:mouse spinal cord | genotype:Trem2 KO/Cre+	Sample source:mouse spinal cord | genotype:Cre-	Sample source:mouse spinal cord | genotype:Cre-	Sample source:mouse spinal cord | genotype:Cre-	Sample source:mouse spinal cord | genotype:Cre-	Sample source:mouse spinal cord | genotype:Cre-	Sample source:mouse spinal cord | genotype:Cre-	Sample source:mouse spinal cord | genotype:Cre-	Sample source:mouse spinal cord | genotype:Cre-	Sample source:mouse spinal cord | genotype:Cre-	Sample source:mouse spinal cord | genotype:Cre-	Sample source:mouse spinal cord | genotype:Cre+	Sample source:mouse spinal cord | genotype:Cre+	Sample source:mouse spinal cord | genotype:Cre+	Sample source:mouse spinal cord | genotype:Cre+	Sample source:mouse spinal cord | genotype:Cre+	Sample source:mouse spinal cord | genotype:Cre+	Sample source:mouse spinal cord | genotype:Cre+	Sample source:mouse spinal cord | genotype:Cre+	Sample source:mouse spinal cord | genotype:Cre+	Sample source:mouse spinal cord | genotype:Cre+	Sample source:mouse spinal cord | genotype:Cre+	Sample source:mouse spinal cord | genotype:Cre+	Sample source:mouse spinal cord | genotype:Trem2 KO/Cre-	Sample source:mouse spinal cord | genotype:Trem2 KO/Cre-	Sample source:mouse spinal cord | genotype:Trem2 KO/Cre-	Sample source:mouse spinal cord | genotype:Trem2 KO/Cre-	Sample source:mouse spinal cord | genotype:Trem2 KO/Cre-	Sample source:mouse spinal cord | genotype:Trem2 KO/Cre-	Sample source:mouse spinal cord | genotype:Trem2 KO/Cre-	Sample source:mouse spinal cord | genotype:Trem2 KO/Cre-	Sample source:mouse spinal cord | genotype:Trem2 KO/Cre+	Sample source:mouse spinal cord | genotype:Trem2 KO/Cre+	Sample source:mouse spinal cord | genotype:Trem2 KO/Cre+	Sample source:mouse spinal cord | genotype:Trem2 KO/Cre+	Sample source:mouse spinal cord | genotype:Trem2 KO/Cre+	Sample source:mouse spinal cord | genotype:Trem2 KO/Cre+	Sample source:mouse spinal cord | genotype:Trem2 KO/Cre+
PE 16:0/16:1, 14:0/18:1	0.35	0.39	0.37	0.38	0.33	0.37	0.38	0.36	0.35	0.39	0.34	0.33	0.34	0.32	0.36	0.33	0.39	0.37	0.35	0.35	0.34	0.35	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00
PE P-16:0/18:2	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	1.17	0.73	0.84	0.86	0.90	0.71	0.90	0.61	0.73	0.98	0.89	0.79	1.05	0.89	0.91	0.64	0.76	0.79	0.68	0.81	0.91	0.57	0.80	0.79	0.58	0.62	0.60	0.49	0.80	0.76	0.68	0.78	1.23	1.14	1.01	0.57	0.77	0.98	0.75	0.77	0.74	0.88	0.80	0.80	0.64	0.75	0.89	0.80	0.65	1.06	0.90	0.43	1.00	0.67	0.68	1.17	0.83	0.97	0.71	0.93	1.00	0.79	0.95	0.82	0.82	1.14	0.99	0.82	0.67	0.92	0.83	1.08	1.13	0.83	0.94	0.90	0.63	1.05	1.02
PE P-18:1/16:0, P-16:0/18:1	5.04	5.06	4.44	5.65	5.37	3.48	4.29	3.34	3.52	2.84	3.87	3.35	3.27	7.52	5.17	4.97	4.07	3.15	2.78	2.70	3.28	4.03	24.38	27.77	25.76	23.49	23.45	25.37	25.29	23.23	25.99	28.13	21.51	22.66	25.83	23.67	24.47	23.48	26.65	22.26	21.35	26.91	25.00	27.00	28.38	20.64	27.19	29.46	22.10	25.47	22.90	29.94	24.00	27.82	21.33	23.26	24.14	20.64	26.83	17.23	25.06	17.47	22.94	20.25	28.57	31.84	24.10	29.90	25.81	26.12	27.32	31.21	25.32	25.26	27.40	31.31	30.95	29.54	25.78	25.20	26.03	23.72	30.51	24.61	23.57	20.81	22.62	29.54	29.38	26.53	23.95	27.82	25.26	30.77	31.74	30.02	26.55	31.80	31.59	30.48	27.23
PE P-18:0/16:0, P-16:0/18:0	0.79	0.80	0.87	0.95	0.90	0.67	0.73	0.64	0.65	0.64	0.63	0.71	0.66	0.90	0.78	0.79	0.76	0.63	0.64	0.52	0.69	0.69	1.96	2.36	2.43	2.08	2.20	2.09	2.51	2.19	2.17	2.39	2.06	2.09	2.33	2.06	2.20	2.14	2.31	2.00	1.85	2.29	2.18	2.70	2.40	1.77	2.45	3.39	2.16	2.23	2.15	2.22	1.99	2.10	1.55	1.97	2.32	1.68	2.34	1.97	1.91	1.96	2.07	1.70	2.60	2.61	2.27	2.75	2.17	2.39	2.33	2.82	2.32	2.49	2.37	2.67	2.48	2.61	2.17	2.10	2.13	1.96	2.49	1.96	1.56	1.67	2.10	2.49	2.57	2.47	2.06	2.49	2.50	2.65	2.51	2.91	2.29	2.69	2.65	2.51	2.16
PE 16:0/18:2, 16:1/18:1	0.44	0.45	0.39	0.44	0.48	0.31	0.41	0.35	0.38	0.32	0.42	0.33	0.32	0.60	0.45	0.42	0.39	0.36	0.34	0.36	0.36	0.40	2.19	1.88	1.91	1.83	1.92	1.62	1.83	1.45	1.86	2.12	1.65	1.87	2.08	1.97	1.96	1.75	1.96	1.76	1.41	2.04	1.92	1.62	1.89	1.65	1.61	1.89	1.45	1.46	1.68	2.18	1.70	2.01	2.14	2.20	2.06	1.48	2.00	2.18	1.90	1.69	1.79	1.93	1.87	2.20	1.61	2.12	2.05	2.01	1.79	2.28	2.08	1.53	2.23	2.18	2.26	2.57	2.02	2.28	1.98	2.02	2.38	2.06	2.11	1.73	1.72	2.30	2.04	1.90	1.65	1.96	1.80	2.40	2.63	2.25	2.20	2.34	2.00	2.48	2.24
PE 16:0/18:1	3.17	3.35	3.30	3.28	3.32	2.52	2.79	2.77	2.43	2.27	2.43	2.61	2.40	4.21	3.33	3.26	2.92	2.83	2.53	2.42	2.75	2.71	6.17	6.39	5.83	6.44	5.82	6.26	6.76	6.01	6.36	6.41	5.69	6.05	5.44	5.43	5.29	5.70	6.06	5.98	6.07	6.49	6.39	5.97	6.09	6.10	6.23	6.28	5.72	6.41	6.04	5.90	5.71	5.56	4.75	5.68	5.29	4.97	6.01	6.03	5.77	5.09	6.08	5.55	6.88	7.78	6.42	7.43	7.15	6.98	6.20	7.69	7.50	6.32	6.87	6.34	6.04	7.10	6.36	6.96	6.49	5.56	6.61	5.04	5.15	4.77	6.25	7.77	7.49	7.04	6.69	6.47	7.02	7.65	6.90	6.61	6.53	6.81	6.71	6.44	5.88
PE P-14:0/22:6	0.25	0.22	0.28	0.22	0.21	0.23	0.26	0.27	0.24	0.24	0.24	0.28	0.23	0.22	0.22	0.25	0.28	0.26	0.27	0.27	0.27	0.27	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00
PE P-16:0/20:4	2.45	2.12	2.13	2.43	2.09	2.02	1.89	2.13	1.49	1.82	2.47	2.27	1.64	1.28	1.79	1.47	2.14	1.49	1.31	1.40	1.53	2.07	2.21	2.41	2.32	2.43	2.04	2.46	2.27	2.02	2.31	2.12	2.22	2.04	2.50	2.35	2.27	2.02	2.33	2.15	2.19	2.08	2.11	2.10	2.30	1.85	2.11	2.87	1.89	2.10	2.22	2.37	2.13	2.52	2.27	2.33	2.58	2.20	2.61	1.46	2.03	2.06	2.16	1.82	2.23	2.10	1.80	2.33	2.20	1.94	2.18	2.34	1.88	1.85	2.20	2.39	2.40	2.09	2.06	2.11	2.02	2.08	2.37	2.20	1.82	1.95	1.83	2.23	2.31	2.10	1.82	2.08	2.01	2.11	2.40	2.16	2.08	2.48	2.30	2.44	2.27
PE P-16:0/20:3, P-18:1/18:2	0.61	0.61	0.55	0.59	0.56	0.46	0.50	0.54	0.44	0.40	0.52	0.52	0.49	0.52	0.56	0.57	0.55	0.39	0.40	0.38	0.42	0.53	3.49	2.23	2.42	2.68	2.62	2.02	2.12	1.46	2.27	2.70	2.02	1.95	2.14	1.87	1.93	1.59	1.99	1.91	1.34	2.32	2.27	1.38	1.98	2.01	1.80	1.96	1.35	1.29	2.03	1.81	1.73	1.66	2.43	2.36	1.80	1.31	1.97	2.82	1.93	2.09	1.64	2.67	1.75	2.57	1.58	1.76	2.00	2.08	1.82	2.57	2.23	1.41	1.91	1.56	1.62	2.65	1.93	2.37	1.94	1.83	2.04	1.50	2.14	1.61	1.89	2.60	2.16	1.97	1.69	2.13	1.77	2.81	2.28	1.61	1.82	1.73	1.51	2.23	2.00
PE P-18:1/18:1, P-18:0/18:2, P-16:0/20:2	13.19	12.65	11.58	14.07	13.60	8.59	9.95	7.78	8.23	6.28	9.06	7.08	7.30	18.90	13.91	13.75	10.33	7.51	6.60	6.38	7.98	10.12	61.68	52.78	48.71	51.01	53.73	46.96	50.16	39.79	52.37	57.97	45.20	46.39	50.16	45.21	47.75	43.21	49.64	44.10	39.80	56.64	54.10	45.79	52.52	46.69	47.08	43.73	39.43	42.61	44.45	53.54	44.15	48.70	47.12	49.07	44.81	38.82	53.24	48.02	48.78	39.28	44.76	43.38	50.28	63.27	42.78	54.12	53.36	51.47	53.25	63.54	54.79	44.47	53.02	52.51	53.37	61.53	50.37	54.72	51.80	47.78	55.72	44.31	52.37	43.60	44.46	61.27	55.42	50.55	45.25	55.69	49.26	67.94	63.97	52.88	51.74	54.45	53.30	58.00	53.40
PE P-18:0/18:1, P-16:0/20:1	7.02	7.08	6.06	7.74	7.63	4.47	5.51	4.26	4.77	3.52	4.71	4.01	4.09	11.17	7.37	7.15	5.35	3.99	3.44	3.23	4.49	5.29	39.55	40.30	36.43	35.17	37.58	36.04	37.65	32.50	39.97	42.82	30.93	32.91	34.50	31.61	33.31	33.07	37.29	31.66	30.39	42.61	39.18	36.60	39.42	33.79	38.46	38.50	31.52	35.54	31.99	40.62	33.43	36.05	27.56	31.20	29.17	26.23	36.79	29.88	35.78	26.43	31.71	30.97	40.04	48.49	34.93	42.65	39.63	39.69	41.01	47.74	42.12	37.50	38.04	39.74	39.91	43.63	37.62	39.43	37.94	32.42	40.83	33.11	34.13	29.52	32.94	44.47	40.97	39.87	35.87	42.36	38.24	49.21	44.74	38.98	37.04	40.39	43.16	42.78	37.28
PE O-18:0/18:1	0.49	0.49	0.44	0.55	0.50	0.34	0.38	0.25	0.29	0.19	0.27	0.27	0.32	0.79	0.48	0.49	0.37	0.30	0.21	0.22	0.32	0.35	2.73	3.30	2.99	3.02	2.71	3.06	3.03	2.85	3.14	2.99	2.30	2.61	2.43	2.43	2.53	2.85	3.13	2.57	2.63	3.17	3.01	3.31	3.35	2.34	3.41	4.70	2.64	3.24	2.69	3.04	2.50	2.95	1.82	2.00	2.14	1.94	2.96	2.25	2.68	1.98	2.39	2.58	3.45	3.61	3.07	3.60	3.08	3.10	3.22	3.89	3.15	3.10	2.74	2.94	3.01	3.34	2.72	2.70	2.41	1.89	2.97	2.12	1.77	1.72	2.47	3.13	3.18	3.17	3.02	3.30	3.27	3.49	3.01	2.90	2.55	3.00	3.27	2.76	2.49
PE 16:0/20:4, 18:2/18:2	2.08	2.12	2.12	2.00	1.90	1.67	2.09	2.13	1.58	1.74	1.90	2.19	1.92	1.95	1.92	1.88	1.97	1.80	1.71	1.73	1.78	1.96	1.81	1.91	1.96	2.47	1.81	2.22	2.39	2.05	1.87	1.69	2.20	2.20	2.15	2.19	1.98	1.83	1.89	2.06	2.38	1.93	2.00	1.87	1.79	1.94	1.88	1.91	1.94	2.07	2.18	1.82	1.92	2.12	1.94	2.29	2.12	1.96	2.19	1.94	1.87	2.10	2.26	1.80	2.04	1.83	1.92	2.31	2.26	1.91	1.78	2.16	2.08	1.68	2.24	1.82	1.88	1.77	1.84	2.09	1.81	1.86	2.14	1.84	1.53	1.73	1.81	2.17	2.27	1.92	1.87	1.70	2.00	1.89	2.10	2.08	2.12	2.25	1.93	2.12	2.03
PE 18:1/18:2, 16:0/20:3	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	1.74	1.45	1.52	1.76	1.55	1.24	1.56	1.27	1.42	1.57	1.43	1.27	1.48	1.30	1.39	1.22	1.44	1.36	1.20	1.47	1.65	1.38	1.48	1.27	1.29	1.35	1.13	1.20	1.37	1.42	1.24	1.47	1.65	1.63	1.57	1.16	1.52	2.16	1.38	1.32	1.24	1.34	1.48	1.58	1.35	1.55	1.61	1.42	1.28	1.69	1.60	1.10	1.46	1.34	1.37	1.64	1.35	1.51	1.23	1.28	1.50	1.15	1.18	1.07	1.31	1.65	1.65	1.40	1.27	1.48	1.29	1.61	1.73	1.49	1.42	1.58	1.40	1.60	1.41
PE 18:0/18:2, 18:1/18:1, 16:0/20:2	4.04	4.27	3.95	4.23	4.11	3.04	3.26	3.07	3.06	2.58	2.89	2.85	2.50	6.29	4.32	4.16	3.47	3.47	3.07	2.83	3.49	3.49	13.54	13.27	11.88	13.60	13.10	12.90	13.96	11.46	13.36	12.70	12.03	11.62	10.34	9.77	10.07	10.70	11.98	11.61	11.79	14.14	13.51	12.45	13.75	12.02	13.21	12.05	10.78	12.79	11.81	11.57	11.16	10.42	10.23	10.96	10.21	9.43	12.31	11.33	11.64	9.76	11.03	10.37	14.13	16.17	12.70	15.09	14.44	14.13	13.22	16.45	14.72	12.12	12.31	11.64	11.73	14.18	12.07	13.00	12.39	10.42	12.53	8.84	10.71	8.51	12.25	16.11	16.09	14.19	13.14	13.79	13.93	17.08	13.98	11.77	11.93	12.41	13.19	12.60	11.31
PE 18:0/18:1, 16:0/20:1	5.78	5.64	5.37	6.13	5.83	4.04	4.16	3.56	3.38	2.96	3.51	3.42	3.32	8.40	6.11	6.41	4.95	4.32	3.06	3.09	3.77	4.09	10.77	11.56	10.53	10.93	10.77	11.27	12.63	11.18	11.30	11.07	10.49	9.89	8.96	8.77	8.42	9.83	10.77	10.36	10.90	11.55	11.58	10.94	11.46	10.58	12.33	11.10	10.44	12.40	10.34	10.17	9.93	9.30	6.73	8.09	7.28	8.28	10.00	9.04	9.97	8.26	9.64	8.78	12.95	14.59	12.22	13.69	13.08	12.68	11.80	14.56	12.80	11.77	11.60	11.10	10.62	12.05	11.09	11.91	11.28	8.34	10.76	7.61	8.52	6.51	11.02	13.92	14.05	13.32	12.78	12.33	12.92	14.51	11.87	11.02	10.57	11.32	11.96	10.77	9.37
PE P-16:0/22:6, 18:0/18:0, P-18:2/20:4	7.23	6.65	7.68	6.59	6.04	6.08	6.21	6.89	5.65	6.07	6.66	6.41	5.90	4.29	5.77	5.64	6.46	5.70	6.15	5.54	5.87	6.50	3.01	3.26	3.30	3.40	3.09	3.53	3.58	3.48	3.15	2.90	3.73	3.43	3.54	3.66	3.47	3.05	2.94	3.34	3.48	3.20	3.11	3.16	2.72	3.38	2.95	3.55	3.38	3.27	3.54	3.01	3.15	3.62	2.84	3.68	3.52	3.07	3.62	4.39	2.81	3.49	3.67	2.77	3.27	3.19	3.05	3.58	3.54	2.75	3.14	3.75	3.50	2.73	3.73	3.23	3.59	2.93	3.09	3.84	3.38	3.67	3.84	3.66	2.70	3.76	2.97	3.43	3.31	3.13	3.08	2.71	3.26	2.92	3.10	3.54	3.62	3.67	3.49	3.54	3.49
PE P-18:1/20:4, P-16:0/22:5	6.54	6.23	6.29	6.52	5.95	4.66	5.35	5.24	4.39	4.15	5.17	4.63	4.61	6.87	6.20	6.37	5.63	4.61	4.30	4.11	4.60	5.60	9.49	10.21	10.04	11.25	9.07	10.55	10.31	9.14	9.66	8.87	9.95	9.37	9.82	9.49	9.19	8.53	9.64	9.39	10.50	10.13	9.41	9.26	9.38	9.18	9.00	9.69	8.94	9.30	9.59	8.92	9.03	9.59	7.62	9.20	9.61	8.83	11.21	8.17	8.52	8.10	9.96	7.36	9.58	9.63	8.04	10.42	9.96	7.98	9.74	10.89	9.09	8.30	9.65	9.24	9.71	7.98	8.52	9.36	8.73	8.84	9.22	8.03	7.06	8.05	8.05	9.91	10.63	8.45	8.10	8.64	8.41	9.00	9.05	8.93	9.03	9.84	9.64	9.14	9.21
PE P-18:0/20:4, P-16:0/22:4, P-18:1/20:3	8.01	7.98	7.98	7.77	7.10	6.03	7.30	7.70	5.78	5.97	7.25	7.00	6.40	7.01	7.21	6.70	6.97	5.84	5.50	5.27	5.80	7.00	10.84	11.55	11.48	11.22	10.31	11.30	11.33	10.32	10.94	10.30	10.84	10.46	10.59	10.85	10.44	9.79	10.62	9.74	10.58	11.51	10.33	10.00	10.17	9.84	10.73	10.38	9.82	10.69	10.43	10.65	9.96	10.97	7.53	9.32	9.55	8.65	11.83	8.47	9.48	8.19	10.20	8.21	11.10	11.83	9.38	11.90	11.40	9.81	11.39	12.69	11.04	9.67	10.81	10.48	11.43	10.36	9.95	11.15	10.38	9.25	11.20	9.85	8.60	9.16	8.50	10.75	10.49	10.37	9.58	10.24	10.16	11.12	10.79	10.28	10.21	11.30	11.74	10.69	10.49
PE P-18:0/20:3	1.32	1.38	1.29	1.33	1.28	0.98	1.14	1.13	0.93	0.91	1.11	1.01	1.01	1.40	1.35	1.23	1.18	0.98	0.81	0.82	0.92	1.00	2.64	2.96	2.80	2.87	2.70	3.07	3.00	2.75	2.85	2.62	2.65	2.63	2.69	2.58	2.65	2.45	2.75	2.40	2.60	2.81	2.65	2.78	2.95	2.36	2.94	3.60	2.61	2.81	2.59	2.71	2.37	2.76	2.06	2.26	2.35	2.00	2.82	1.92	2.38	2.01	2.34	2.00	2.95	3.02	2.48	3.11	2.83	2.54	2.77	3.28	2.86	2.61	2.65	2.77	2.89	2.86	2.52	2.64	2.39	2.17	2.86	2.41	2.09	2.00	2.29	2.94	3.00	2.78	2.56	2.76	2.61	3.00	2.88	2.77	2.49	2.85	2.94	2.66	2.58
PE P-20:1/18:1, P-18:1/20:1	5.26	5.20	4.50	5.85	6.02	3.31	3.56	2.64	2.80	2.04	3.03	2.56	2.32	8.11	5.64	5.69	4.05	2.90	2.15	2.12	2.84	3.70	19.28	24.90	21.44	20.87	20.41	24.13	23.35	22.63	24.04	20.89	17.28	18.12	17.92	16.90	17.26	19.30	22.40	18.01	21.25	23.36	21.72	24.92	25.39	18.35	25.77	26.79	21.22	25.09	19.47	22.94	20.26	22.01	12.77	15.90	17.03	16.37	22.81	10.79	20.25	14.08	19.59	15.57	26.03	27.06	21.24	27.21	23.23	21.80	25.02	27.48	21.75	23.43	19.90	22.97	23.31	20.66	19.50	18.16	18.96	16.07	20.83	15.73	13.16	13.29	19.96	25.03	27.17	23.66	21.85	24.06	22.60	24.42	21.23	21.56	19.24	23.20	26.60	20.96	18.59
PE P-18:1/20:0	2.28	2.28	1.93	2.55	2.72	1.39	1.65	1.19	1.40	0.92	1.35	1.19	1.12	3.82	2.43	2.43	1.73	1.21	0.98	0.90	1.30	1.62	12.51	16.38	14.04	12.94	13.29	15.18	15.25	14.81	15.31	14.29	11.16	12.01	11.57	10.91	11.36	12.98	14.24	11.48	13.32	15.62	14.42	15.61	16.44	11.49	17.06	18.02	13.70	16.68	12.44	15.47	13.10	14.82	7.71	9.55	10.00	10.37	14.11	6.92	13.39	8.51	12.10	10.27	17.27	18.46	14.47	17.85	14.92	14.52	16.52	18.11	14.61	16.15	13.16	15.63	15.63	14.05	13.14	12.27	12.61	10.02	14.42	10.80	8.89	8.87	12.66	16.04	16.56	15.56	14.25	15.66	14.93	16.27	14.42	14.51	12.85	15.62	17.63	14.09	12.40
PE P-20:0/18:0, P-18:0/20:0	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	2.63	2.60	2.19	2.64	2.23	2.04	2.48	2.14	2.44	2.17	2.07	2.43	2.03	1.75	1.78	1.94	2.36	2.11	1.84	2.40	2.39	2.31	2.32	1.81	2.55	2.93	1.86	2.35	2.15	2.33	2.09	2.18	1.44	1.79	1.65	1.58	2.10	1.66	1.97	1.70	1.92	2.10	2.68	2.70	2.18	2.83	2.47	2.51	2.33	2.81	2.37	2.33	2.05	2.45	2.28	2.83	2.22	2.38	2.03	1.73	2.13	1.56	1.53	1.42	1.84	2.48	2.46	2.38	2.05	2.36	2.45	2.51	2.21	2.18	2.07	2.17	2.31	2.33	1.79
PE 16:1-22:6	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.89	0.79	0.51	0.91	0.76	0.47	0.91	0.64	0.66	0.60	0.88	0.94	0.76	0.67	0.57	0.51	0.67	0.73	0.66	0.71	0.76	0.52	0.54	0.60	0.71	0.68	0.59	0.59	0.70	0.66	0.71	0.83	0.64	0.82	0.69	0.54	0.65	0.61	0.57	0.73	0.74	0.82	0.91	0.74	0.73	0.77	0.93	0.79	0.55	0.89	0.86	0.56	0.85	0.86	0.75	1.04	0.83	1.04	0.74	0.72	0.79	0.73	0.66	0.66	0.60	0.81	0.79	0.75	0.67	0.76	0.92	0.85	0.75	0.84	0.78	0.87	0.71	0.93	0.77
PE 16:0/22:6	5.84	5.75	7.40	5.33	5.65	4.87	5.85	6.94	5.85	5.50	5.46	5.83	5.94	4.72	5.38	5.77	5.95	6.39	7.00	6.49	6.25	6.36	3.09	3.56	3.60	4.12	3.28	3.82	4.16	3.99	3.36	3.00	4.53	4.11	3.75	3.93	3.48	3.43	3.20	4.02	4.24	3.43	3.50	3.42	3.04	3.90	3.15	3.76	3.92	3.82	4.22	3.10	3.59	3.83	3.48	4.35	4.29	3.51	4.19	6.24	3.28	3.94	4.14	3.17	3.55	3.40	3.44	3.85	3.87	3.09	3.05	3.79	3.94	2.78	4.18	3.33	3.60	3.00	3.29	4.25	3.61	4.02	4.13	3.83	3.04	4.08	3.31	3.64	3.76	3.40	3.49	2.74	3.65	3.09	3.27	3.69	4.00	3.95	3.81	3.74	3.80
PE 18:1/20:4, 16:0/22:5	3.30	3.38	3.38	3.43	3.39	2.53	3.05	2.96	2.60	2.58	2.77	2.90	2.60	3.82	3.30	3.19	2.91	2.90	2.94	2.72	2.86	3.06	5.87	6.35	6.04	7.22	5.78	6.31	6.73	5.96	6.14	5.22	6.21	5.83	5.71	5.46	5.18	5.21	5.88	5.79	6.41	6.21	6.06	6.12	6.48	5.68	6.04	6.06	5.30	6.42	6.24	5.53	5.60	5.91	5.52	5.85	6.05	5.51	6.82	5.79	5.57	5.27	6.02	5.24	6.36	6.28	5.58	7.05	6.74	5.81	5.97	6.88	6.04	5.11	5.75	5.45	5.52	5.31	5.23	5.53	5.36	5.12	5.76	4.69	4.42	4.57	5.24	6.31	6.87	5.76	5.57	5.46	5.99	6.34	5.73	5.46	5.44	6.06	5.93	5.94	5.42
PE 18:0/20:4, 16:0/22:4	17.05	18.18	17.67	16.55	15.99	14.16	16.73	17.47	12.13	13.89	15.67	17.50	14.93	13.79	15.51	14.74	15.73	14.30	12.74	12.97	13.08	15.38	8.62	9.80	9.54	11.05	8.91	10.79	11.31	10.13	9.57	8.31	10.05	9.80	9.02	9.21	8.26	8.87	8.67	9.41	10.88	9.78	9.47	9.30	9.18	10.18	9.68	9.76	9.91	11.15	9.68	8.52	9.07	8.97	6.71	8.74	8.76	8.65	10.53	8.96	8.72	9.11	10.13	7.74	10.31	10.48	9.70	11.54	11.24	9.41	9.77	11.32	10.66	8.76	10.26	9.02	9.64	8.35	8.60	10.23	9.14	7.64	9.11	7.80	6.60	6.87	8.91	10.33	10.68	10.31	9.90	8.50	10.24	9.65	8.75	9.01	9.33	9.70	9.77	9.08	8.72
PE 18:0/20:3, 18:1/20:2, 16:0/22:3	0.68	0.70	0.67	0.65	0.60	0.53	0.63	0.62	0.50	0.43	0.57	0.63	0.48	0.63	0.63	0.63	0.57	0.56	0.43	0.48	0.49	0.54	1.03	1.03	1.11	1.04	0.98	0.99	1.24	1.11	1.09	1.03	1.06	0.96	1.08	1.03	0.97	0.94	1.15	0.99	1.15	1.01	1.20	1.11	1.07	1.01	1.10	1.22	1.02	1.13	1.11	1.04	0.96	1.11	0.80	0.92	0.99	0.83	1.18	0.91	0.93	0.84	1.10	0.99	1.27	1.09	1.06	1.33	1.24	1.11	1.02	1.25	1.15	0.89	1.04	1.02	1.05	1.11	0.96	1.08	0.84	0.85	1.09	0.81	0.69	0.67	0.95	1.19	1.30	1.12	1.08	1.08	1.12	1.15	1.16	1.13	1.09	1.20	1.04	1.02	0.99
PE P-18:2/22:6, 18:1/20:1	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	3.32	4.13	3.61	3.68	3.39	4.08	4.17	3.79	4.06	2.87	2.72	2.74	2.21	1.92	2.37	2.91	3.59	2.83	3.71	3.97	3.89	4.16	4.71	2.91	4.60	4.93	3.23	4.31	3.16	3.20	2.96	3.05	1.42	1.95	2.14	2.36	3.18	1.78	3.11	2.21	2.80	2.71	4.40	4.41	3.75	4.54	3.79	3.78	3.88	4.34	3.63	3.80	2.59	3.22	2.92	3.28	2.78	2.60	2.49	1.75	2.70	1.56	1.27	1.30	3.43	4.17	4.54	4.04	3.77	4.05	3.93	4.10	2.83	2.82	2.54	2.90	3.72	2.72	2.09
PE P-18:1/22:6, 18:0/20:1	3.76	3.65	4.07	3.57	3.46	2.85	3.22	3.48	2.95	2.83	3.26	2.96	3.02	3.36	3.41	3.57	3.26	3.08	3.36	2.99	2.97	3.41	4.22	5.02	4.85	4.74	4.40	5.25	5.24	4.92	4.92	4.02	4.64	4.37	3.76	3.77	3.79	4.17	4.69	4.36	4.61	4.96	4.54	5.15	5.05	4.29	5.21	5.56	4.50	5.15	4.58	4.46	4.19	4.64	2.56	3.61	3.71	3.58	4.83	3.91	3.97	3.70	4.15	3.72	5.31	5.32	4.57	5.68	4.99	4.58	4.91	5.69	5.08	4.72	4.40	4.58	4.71	4.66	4.13	4.51	4.10	3.66	4.40	3.52	2.63	3.11	4.32	5.07	5.34	5.03	4.89	4.68	5.11	4.86	4.14	4.27	4.23	4.56	5.14	4.38	3.84
PE P-18:0/22:6, P-18:1/22:5, 18:0/20:0	11.26	11.68	12.79	10.51	10.17	8.55	10.35	11.53	9.79	8.85	9.71	9.53	9.40	10.95	10.27	10.24	10.16	9.82	11.26	9.68	10.08	10.66	5.94	6.74	6.87	6.92	6.26	7.38	7.40	7.29	6.37	5.70	7.42	7.19	6.62	7.00	6.41	6.33	5.83	6.27	7.40	6.51	6.32	6.62	5.66	7.31	6.08	6.98	7.27	6.85	7.17	5.91	6.25	6.82	5.03	6.85	6.73	5.84	7.44	6.65	5.55	6.46	7.21	5.24	6.56	6.69	6.31	7.48	7.27	5.38	6.67	7.97	7.51	5.62	7.28	6.30	7.05	6.11	6.07	7.90	6.39	6.67	7.11	6.86	4.86	6.93	6.13	6.76	7.00	6.51	6.31	5.57	6.82	6.00	5.76	6.41	7.02	6.73	6.95	6.51	6.81
PE P-18:0/22:5, P-18:1/22:4	4.85	4.89	4.66	4.70	4.44	3.47	3.56	3.61	3.13	2.73	3.37	3.07	3.20	5.43	4.78	5.00	3.97	3.24	2.88	2.74	3.20	3.71	8.41	9.12	8.66	8.99	8.30	9.61	9.10	8.87	8.70	7.77	7.93	7.82	7.42	7.12	7.30	7.00	8.16	7.41	8.70	8.80	8.30	8.57	8.67	7.89	8.98	9.49	8.03	8.82	8.16	7.28	7.46	7.36	5.05	6.15	6.33	6.83	8.70	6.59	7.14	6.27	7.69	6.28	8.75	9.39	8.00	10.15	9.08	7.72	9.16	10.16	9.03	7.86	7.69	7.38	7.91	7.78	7.37	8.15	7.25	5.89	7.35	5.88	5.37	5.39	6.85	8.69	8.61	8.44	7.86	8.12	8.69	9.19	7.38	7.11	7.12	7.97	8.85	7.27	6.89
PE P-18:0/22:4, P-20:0/20:4, P-18:1/22:3	3.79	4.09	3.80	3.62	3.22	2.93	3.29	3.46	2.65	2.80	3.14	3.06	2.84	3.67	3.63	3.52	3.35	2.77	2.51	2.49	2.77	3.19	6.12	6.33	5.67	5.96	5.94	6.50	6.45	5.91	6.03	6.00	5.89	5.89	5.52	5.26	5.11	5.23	5.75	5.18	5.57	6.17	5.83	5.54	5.47	5.43	6.26	6.79	5.51	5.90	5.44	5.48	5.28	5.42	3.49	4.27	4.31	4.52	6.07	4.56	5.03	4.49	5.17	4.65	6.21	7.04	5.54	7.18	6.53	5.79	6.41	7.49	6.64	5.58	5.61	5.35	5.68	6.50	5.54	6.00	5.46	4.37	5.83	4.75	4.58	4.23	4.68	6.10	5.61	6.09	5.42	6.02	6.18	6.98	5.67	5.27	5.29	5.69	6.26	5.80	5.32
PE O-20:0/20:4, P-18:0/22:3	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.96	1.05	0.96	1.07	0.96	1.02	1.18	1.01	1.00	0.91	1.02	1.03	0.99	0.84	1.01	0.78	0.98	0.96	0.87	1.05	1.04	0.95	1.10	0.87	1.05	0.93	0.97	0.99	0.90	0.89	0.96	0.91	0.64	0.83	0.86	0.75	0.98	0.74	0.79	0.81	0.86	0.77	1.14	1.06	0.95	1.15	1.09	1.03	0.96	1.27	1.02	0.79	0.91	0.89	0.86	1.28	0.91	1.07	0.88	0.71	1.01	0.82	0.67	0.69	0.82	1.13	1.03	1.03	0.89	1.11	1.19	1.15	1.07	0.84	0.92	0.95	0.93	1.09	0.89
PE P-18:0/22:2	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	2.45	3.08	2.55	2.61	2.41	2.87	2.81	2.66	2.80	2.35	2.13	2.18	1.89	1.68	2.00	2.12	2.70	2.11	2.45	2.84	2.78	2.73	2.99	2.20	3.13	3.56	2.54	2.91	2.30	2.48	2.22	2.43	1.34	1.82	1.90	1.95	2.47	1.42	2.29	1.68	2.19	2.08	3.20	3.18	2.53	3.20	2.84	2.58	2.88	3.33	2.72	2.73	2.18	2.57	2.37	2.68	2.21	2.20	2.02	1.69	2.27	1.51	1.32	1.34	2.43	3.29	3.47	2.75	2.50	3.04	2.76	3.00	2.38	2.22	2.15	2.40	2.80	2.29	1.93
PE 18:2/22:6	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.77	0.73	0.61	0.91	0.61	0.57	0.75	0.66	0.68	0.56	0.67	0.76	0.69	0.50	0.53	0.47	0.76	0.65	0.67	0.71	0.81	0.61	0.72	0.61	0.88	0.81	0.49	0.67	0.81	0.67	0.65	0.77	0.77	0.71	0.64	0.54	0.68	1.47	0.73	0.79	0.78	0.62	0.99	0.82	0.77	0.97	0.92	0.86	0.73	0.99	0.93	0.73	0.84	0.81	0.73	0.94	0.88	0.89	0.69	0.71	0.77	0.67	0.67	0.61	0.85	0.98	0.97	0.91	0.82	0.92	1.04	1.00	0.90	0.85	0.80	0.94	0.80	1.00	0.76
PE 18:1/22:6	2.11	1.98	2.43	2.00	1.95	1.68	1.91	2.02	1.83	1.85	1.98	1.89	1.87	2.19	2.13	2.03	1.89	2.02	2.09	1.91	2.02	2.11	1.64	1.76	1.52	2.11	1.66	1.83	2.18	1.81	1.68	1.36	2.10	1.98	1.80	1.77	1.57	1.50	1.79	1.89	1.97	1.80	1.67	1.71	1.76	1.83	1.97	1.57	1.64	1.73	2.01	1.56	1.77	1.86	1.78	2.09	2.04	1.83	2.10	3.33	1.91	2.34	2.18	1.63	2.02	1.75	1.78	1.98	2.23	1.81	1.72	2.18	2.54	1.77	2.53	2.02	1.96	2.69	2.21	2.47	2.14	2.38	2.23	2.67	2.43	2.29	2.27	2.44	2.39	2.35	2.38	2.08	2.44	2.55	2.50	2.48	2.37	2.40	2.04	2.35	2.20
PE 18:0/22:6, 18:1/22:5	21.39	21.20	26.29	19.83	18.82	17.39	20.62	23.43	20.79	19.14	19.43	19.19	19.85	21.65	20.73	20.46	20.65	22.54	24.81	22.79	22.78	22.81	11.82	14.43	13.57	15.78	12.01	15.01	16.38	15.68	13.65	12.14	15.80	15.27	14.65	15.99	14.04	13.92	12.39	14.59	16.66	13.00	13.20	14.13	12.35	15.50	13.68	14.36	15.32	16.32	15.52	12.26	14.69	15.18	12.63	17.25	16.13	14.06	16.57	14.68	12.70	13.17	16.88	11.21	15.02	14.68	14.96	16.93	15.59	12.58	14.24	16.76	15.44	12.50	17.62	15.06	15.56	12.87	14.16	15.76	15.47	16.64	18.26	15.88	13.46	17.09	13.45	14.55	15.99	14.33	14.70	11.10	15.30	13.46	13.80	15.07	15.74	16.37	16.62	15.50	15.54
PE 18:0/22:5, 18:1/22:4	1.27	1.35	1.40	1.23	1.15	1.00	1.14	1.25	1.04	1.04	1.07	1.10	1.11	1.23	1.20	1.23	1.18	1.29	1.18	1.19	1.05	1.19	1.38	1.49	1.60	1.62	1.52	1.59	1.77	1.69	1.60	1.01	1.71	1.19	1.14	1.08	1.24	1.26	1.34	1.33	1.54	1.36	1.50	1.56	1.51	1.45	1.50	1.27	1.45	1.65	1.53	1.11	1.19	1.23	0.88	1.23	1.19	1.15	1.45	1.43	1.18	1.37	1.42	1.36	1.65	1.48	1.47	1.73	1.69	1.39	1.52	1.71	1.60	1.22	1.28	1.14	1.19	1.25	1.17	1.31	0.99	1.01	1.26	0.94	0.70	0.84	1.32	1.52	1.78	1.49	1.48	1.31	1.58	1.48	1.22	1.25	1.18	1.28	1.34	1.27	1.09
PE 20:0/20:4, 18:0/22:4	2.63	2.78	2.71	2.55	2.23	2.13	2.30	2.57	1.82	2.14	2.23	2.31	2.13	2.18	2.51	2.30	2.41	2.21	1.82	1.89	1.97	2.23	1.37	1.52	1.26	1.62	1.29	1.71	1.69	1.68	1.49	1.23	1.43	1.59	1.12	1.32	1.11	1.29	1.28	1.36	1.59	1.49	1.46	1.41	1.26	1.52	1.54	1.86	1.53	1.75	1.38	1.11	1.25	1.21	0.81	0.99	1.04	1.00	1.37	1.08	1.18	1.31	1.39	1.21	1.65	1.53	1.60	1.85	1.75	1.51	1.54	1.82	1.80	1.34	1.39	1.25	1.25	1.46	1.31	1.57	1.19	0.92	1.25	1.04	0.71	0.75	1.32	1.53	1.52	1.72	1.69	1.36	1.69	1.46	1.22	1.30	1.23	1.30	1.33	1.20	1.11
PE 20:0/20:2, 18:0/22:2	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.62	0.54	0.45	0.47	0.54	0.58	0.67	0.54	0.60	0.43	0.53	0.47	0.33	0.32	0.41	0.40	0.52	0.44	0.54	0.56	0.67	0.54	0.58	0.49	0.61	0.54	0.46	0.52	0.44	0.42	0.40	0.56	0.25	0.33	0.29	0.32	0.45	0.41	0.41	0.43	0.40	0.57	0.72	0.54	0.58	0.66	0.61	0.57	0.48	0.74	0.64	0.42	0.43	0.37	0.32	0.62	0.45	0.44	0.29	0.53	0.47	0.22	0.17	0.21	0.50	0.71	0.73	0.65	0.60	0.67	0.65	0.68	0.52	0.44	0.44	0.45	0.41	0.43	0.39
PE 20:0/20:1, 18:0/22:1	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.55	0.32	0.38	0.33	0.35	0.32	0.41	0.36	0.36	0.35	0.44	0.43	0.34	0.27	0.29	0.26	0.31	0.39	0.39	0.35	0.45	0.20	0.24	0.36	0.28	0.72	0.23	0.23	0.30	0.29	0.27	0.40	0.34	0.35	0.23	0.19	0.32	0.54	0.26	0.31	0.33	0.36	0.39	0.34	0.37	0.32	0.40	0.37	0.26	0.48	0.42	0.22	0.37	0.23	0.19	0.56	0.35	0.38	0.22	0.49	0.36	0.27	0.25	0.25	0.35	0.44	0.39	0.37	0.34	0.39	0.41	0.46	0.44	0.30	0.36	0.32	0.18	0.40	0.34
PE 20:6/22:7	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.50	0.29	0.46	0.45	0.45	0.40	0.50	0.43	0.30	0.34	0.33	0.40	0.43	0.40	0.43	0.30	0.37	0.34	0.43	0.30	0.51	0.27	0.37	0.45	0.32	0.36	0.35	0.26	0.41	0.29	0.35	0.43	0.26	0.40	0.32	0.21	0.46	0.54	0.31	0.47	0.40	0.37	0.44	0.32	0.43	0.45	0.49	0.33	0.28	0.58	0.56	0.26	0.47	0.26	0.23	0.56	0.41	0.49	0.24	0.37	0.46	0.37	0.27	0.34	0.38	0.43	0.47	0.44	0.39	0.43	0.56	0.54	0.48	0.42	0.43	0.45	0.25	0.46	0.45
PE 20:6/22:6	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.42	0.27	0.25	0.39	0.30	0.24	0.37	0.29	0.23	0.23	0.41	0.35	0.29	0.30	0.31	0.17	0.27	0.31	0.31	0.22	0.34	0.12	0.14	0.29	0.22	0.14	0.27	0.16	0.30	0.17	0.22	0.31	0.23	0.31	0.27	0.21	0.22	0.21	0.18	0.34	0.32	0.37	0.37	0.21	0.32	0.34	0.41	0.27	0.20	0.42	0.41	0.15	0.32	0.18	0.15	0.48	0.32	0.47	0.20	0.31	0.35	0.28	0.20	0.27	0.26	0.37	0.35	0.33	0.26	0.34	0.40	0.40	0.32	0.30	0.35	0.29	0.15	0.36	0.36
PE 20:4/22:6	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.35	0.30	0.33	0.30	0.29	0.29	0.41	0.41	0.29	0.22	0.38	0.44	0.34	0.34	0.36	0.21	0.35	0.38	0.38	0.27	0.43	0.21	0.26	0.37	0.27	0.23	0.30	0.23	0.37	0.27	0.34	0.45	0.31	0.40	0.36	0.27	0.33	0.32	0.28	0.39	0.39	0.37	0.51	0.27	0.39	0.43	0.48	0.30	0.24	0.50	0.49	0.25	0.48	0.33	0.28	0.47	0.46	0.68	0.34	0.52	0.50	0.41	0.20	0.37	0.43	0.53	0.56	0.46	0.39	0.48	0.48	0.45	0.47	0.45	0.51	0.51	0.23	0.48	0.47
PE 22:6/22:6	0.54	0.52	0.79	0.44	0.53	0.59	0.51	0.44	0.53	0.66	0.62	0.61	0.61	0.55	0.57	0.47	0.44	0.56	0.67	0.50	0.79	0.58	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00
Cer 18:1;O2/18:0	4.55	3.61	4.13	4.40	3.84	4.43	3.50	3.50	2.70	3.33	3.59	3.70	3.20	2.71	3.41	2.94	3.56	3.01	3.55	3.65	3.30	3.74	0.87	0.91	1.07	0.82	1.18	1.11	0.95	1.49	0.64	0.45	1.12	1.17	1.07	1.04	1.15	0.75	0.78	0.86	0.71	0.90	0.72	1.01	0.62	0.82	0.72	0.74	1.09	0.84	0.78	0.70	0.84	0.73	0.76	0.76	1.04	0.61	0.57	0.98	0.52	0.62	0.44	0.41	0.57	0.65	0.57	1.18	0.56	0.77	0.57	0.78	0.63	0.72	1.05	1.23	0.65	0.51	0.61	0.85	0.57	1.22	0.88	1.24	0.68	0.84	0.99	0.60	0.71	0.56	0.55	0.86	0.66	0.61	0.71	0.67	0.88	0.81	0.38	0.71	0.66
Cer 18:1;O2/24:1	0.75	0.63	0.62	0.89	0.78	0.61	0.50	0.38	0.49	0.51	0.49	0.39	0.43	0.96	0.80	0.87	0.66	0.53	0.39	0.50	0.60	0.54	1.38	1.47	1.65	1.61	1.69	1.45	1.42	1.57	1.63	1.03	1.40	1.09	1.24	1.21	1.25	1.30	1.23	0.91	0.43	1.29	1.01	1.58	1.20	0.69	1.08	1.11	1.16	1.70	1.02	0.95	0.76	1.05	0.78	0.88	0.93	0.68	0.82	0.50	0.74	0.54	0.63	0.85	0.90	1.06	0.79	1.32	0.90	0.89	0.71	0.71	0.69	0.96	0.76	1.11	1.28	0.98	0.63	0.66	0.51	0.88	1.08	1.00	0.79	0.44	0.53	0.46	0.67	0.85	0.77	1.10	0.36	0.50	0.68	0.82	0.63	0.88	0.45	1.01	0.72
Cer 18:1;O2/24:0	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.31	0.09	0.45	0.35	0.26	0.24	0.23	0.39	0.30	0.29	0.41	0.32	0.39	0.19	0.40	0.32	0.24	0.28	0.24	0.31	0.22	0.33	0.28	0.17	0.28	0.25	0.21	0.22	0.19	0.34	0.20	0.22	0.26	0.30	0.28	0.15	0.23	0.11	0.21	0.17	0.17	0.16	0.27	0.33	0.18	0.28	0.04	0.21	0.19	0.19	0.23	0.33	0.26	0.34	0.45	0.32	0.21	0.17	0.13	0.16	0.35	0.20	0.20	0.23	0.14	0.11	0.12	0.36	0.13	0.26	0.10	0.15	0.20	0.41	0.25	0.38	0.17	0.35	0.19
MS_METABOLITE_DATA_END
#METABOLITES
METABOLITES_START
metabolite_name	molecular weight
PE 16:0/16:1, 14:0/18:1	689.4996
PE P-16:0/18:2	699.5203
PE P-18:1/16:0, P-16:0/18:1	701.5359
PE P-18:0/16:0, P-16:0/18:0	703.5516
PE 16:0/18:2, 16:1/18:1	715.5152
PE 16:0/18:1	717.5309
PE P-14:0/22:6	719.4890
PE P-16:0/20:4	723.5203
PE P-16:0/20:3, P-18:1/18:2	725.5359
PE P-18:1/18:1, P-18:0/18:2, P-16:0/20:2	727.5516
PE P-18:0/18:1, P-16:0/20:1	729.5672
PE O-18:0/18:1	731.5829
PE 16:0/20:4, 18:2/18:2	739.5152
PE 18:1/18:2, 16:0/20:3	741.5309
PE 18:0/18:2, 18:1/18:1, 16:0/20:2	743.5465
PE 18:0/18:1, 16:0/20:1	745.5622
PE P-16:0/22:6, 18:0/18:0, P-18:2/20:4	747.5203
PE P-18:1/20:4, P-16:0/22:5	749.5359
PE P-18:0/20:4, P-16:0/22:4, P-18:1/20:3	751.5516
PE P-18:0/20:3	753.5672
PE P-20:1/18:1, P-18:1/20:1	755.5829
PE P-18:1/20:0	757.5985
PE P-20:0/18:0, P-18:0/20:0	759.6142
PE 16:1-22:6	761.4996
PE 16:0/22:6	763.5152
PE 18:1/20:4, 16:0/22:5	765.5309
PE 18:0/20:4, 16:0/22:4	767.5465
PE 18:0/20:3, 18:1/20:2, 16:0/22:3	769.5622
PE P-18:2/22:6, 18:1/20:1	771.5203
PE P-18:1/22:6, 18:0/20:1	773.5359
PE P-18:0/22:6, P-18:1/22:5, 18:0/20:0	775.5516
PE P-18:0/22:5, P-18:1/22:4	777.5672
PE P-18:0/22:4, P-20:0/20:4, P-18:1/22:3	779.5829
PE O-20:0/20:4, P-18:0/22:3	781.5985
PE P-18:0/22:2	783.6142
PE 18:2/22:6	787.5152
PE 18:1/22:6	789.5309
PE 18:0/22:6, 18:1/22:5	791.5465
PE 18:0/22:5, 18:1/22:4	793.5622
PE 20:0/20:4, 18:0/22:4	795.5778
PE 20:0/20:2, 18:0/22:2	799.6091
PE 20:0/20:1, 18:0/22:1	801.6248
PE 20:6/22:7	805.4683
PE 20:6/22:6	807.4839
PE 20:4/22:6	811.5152
PE 22:6/22:6	835.5152
Cer 18:1;O2/18:0	565.5434
Cer 18:1;O2/24:1	647.6216
Cer 18:1;O2/24:0	649.6373
METABOLITES_END
#END