#METABOLOMICS WORKBENCH alanyl_20250326_093500 DATATRACK_ID:5789 STUDY_ID:ST003831 ANALYSIS_ID:AN007410 PROJECT_ID:PR002390
VERSION             	1
CREATED_ON             	April 1, 2025, 9:33 am
#PROJECT
PR:PROJECT_TITLE                 	In vivo CRISPR screen identifies copper metabolism as a vulnerability in acute
PR:PROJECT_TITLE                 	lymphoblastic leukemia
PR:PROJECT_SUMMARY               	The nutrient-sparse cerebrospinal fluid (CSF) poses a significant challenge to
PR:PROJECT_SUMMARY               	spreading cancer cells. Despite this challenge, leukemia often spreads to the
PR:PROJECT_SUMMARY               	CSF and represents a significant clinical complication. To uncover nutritional
PR:PROJECT_SUMMARY               	dependencies of leukemia cells in the CSF that could be targeted
PR:PROJECT_SUMMARY               	therapeutically, we conducted an in vivo targeted CRISPR screen in a xenograft
PR:PROJECT_SUMMARY               	model of leukemia. We found that SLC31A1, the primary cell surface copper
PR:PROJECT_SUMMARY               	importer, is a genetic dependency of leukemia in both the central nervous system
PR:PROJECT_SUMMARY               	as well as in the hematopoietic organs. Perturbation of copper metabolism leads
PR:PROJECT_SUMMARY               	to complex IV deficiency, perturbed nucleotide metabolism and slowed leukemia
PR:PROJECT_SUMMARY               	cell proliferation. Furthermore, nutritional copper depletion reduced cancer
PR:PROJECT_SUMMARY               	progression in cell line based and patient-derived xenograft models of leukemia.
PR:PROJECT_SUMMARY               	Copper thus appears to be an actionable micronutrient in leukemia.
PR:INSTITUTE                     	Boston Children's Hospital
PR:DEPARTMENT                    	Pathology
PR:LABORATORY                    	Naama Kanarek
PR:LAST_NAME                     	Wong
PR:FIRST_NAME                    	Alan
PR:ADDRESS                       	300 Longwood Avenue, Boston, MA, 02115, USA
PR:EMAIL                         	alan.wong@childrens.harvard.edu
PR:PHONE                         	(617) 355-7433
PR:FUNDING_SOURCE                	NCI 1R01CA282477-01A1
#STUDY
ST:STUDY_TITLE                   	Folate profiling of human CSF from pediatric ALL patients
ST:STUDY_SUMMARY                 	To investigate the changes in CSF metabolites in human pediatric acute
ST:STUDY_SUMMARY                 	lymphoblastic leukemia (ALL) patients, human CSF from 57 pediatric ALL patients
ST:STUDY_SUMMARY                 	was collected at 5 standardized time points as part of the DFCI 16-001 trial and
ST:STUDY_SUMMARY                 	subjected to non-polar and polar metabolomics. Analysis of folate species in
ST:STUDY_SUMMARY                 	these CSF samples revealed expected changes in 5-methyl tetrahydrofolate levels,
ST:STUDY_SUMMARY                 	consistent with the effects of methotrexate treatment.
ST:INSTITUTE                     	Boston Childrens Hospital
ST:LAST_NAME                     	Wong
ST:FIRST_NAME                    	Alan
ST:ADDRESS                       	300 Longwood Avenue
ST:EMAIL                         	alan.wong@childrens.harvard.edu
ST:PHONE                         	(617) 355-7433
ST:NUM_GROUPS                    	4
#SUBJECT
SU:SUBJECT_TYPE                  	Mammal
SU:SUBJECT_SPECIES               	Homo sapiens
SU:TAXONOMY_ID                   	9606
SU:GENDER                        	Male and female
#SUBJECT_SAMPLE_FACTORS:         	SUBJECT(optional)[tab]SAMPLE[tab]FACTORS(NAME:VALUE pairs separated by |)[tab]Raw file names and additional sample data
SUBJECT_SAMPLE_FACTORS           	-	NK496	Sample source:Human CSF | Timepoint:F0	RAW_FILE_NAME()=20210628_QEF2_C18_folatePColeCSF_NK496.raw
SUBJECT_SAMPLE_FACTORS           	-	NK497	Sample source:Human CSF | Timepoint:F1	RAW_FILE_NAME()=20210628_QEF2_C18_folatePColeCSF_NK497.raw
SUBJECT_SAMPLE_FACTORS           	-	NK498	Sample source:Human CSF | Timepoint:F2	RAW_FILE_NAME()=20210628_QEF2_C18_folatePColeCSF_NK498.raw
SUBJECT_SAMPLE_FACTORS           	-	NK499	Sample source:Human CSF | Timepoint:F3	RAW_FILE_NAME()=20210628_QEF2_C18_folatePColeCSF_NK499.raw
SUBJECT_SAMPLE_FACTORS           	-	NK500	Sample source:Human CSF | Timepoint:F4	RAW_FILE_NAME()=20210628_QEF2_C18_folatePColeCSF_NK500.raw
SUBJECT_SAMPLE_FACTORS           	-	NK501	Sample source:Human CSF | Timepoint:F0	RAW_FILE_NAME()=20210628_QEF2_C18_folatePColeCSF_NK501.raw
SUBJECT_SAMPLE_FACTORS           	-	NK502	Sample source:Human CSF | Timepoint:F1	RAW_FILE_NAME()=20210628_QEF2_C18_folatePColeCSF_NK502.raw
SUBJECT_SAMPLE_FACTORS           	-	NK503	Sample source:Human CSF | Timepoint:F2	RAW_FILE_NAME()=20210628_QEF2_C18_folatePColeCSF_NK503.raw
SUBJECT_SAMPLE_FACTORS           	-	NK504	Sample source:Human CSF | Timepoint:F3	RAW_FILE_NAME()=20210628_QEF2_C18_folatePColeCSF_NK504.raw
SUBJECT_SAMPLE_FACTORS           	-	NK505	Sample source:Human CSF | Timepoint:F4	RAW_FILE_NAME()=20210628_QEF2_C18_folatePColeCSF_NK505.raw
SUBJECT_SAMPLE_FACTORS           	-	NK506	Sample source:Human CSF | Timepoint:F0	RAW_FILE_NAME()=20210628_QEF2_C18_folatePColeCSF_NK506.raw
SUBJECT_SAMPLE_FACTORS           	-	NK507	Sample source:Human CSF | Timepoint:F1	RAW_FILE_NAME()=20210628_QEF2_C18_folatePColeCSF_NK507.raw
SUBJECT_SAMPLE_FACTORS           	-	NK508	Sample source:Human CSF | Timepoint:F2	RAW_FILE_NAME()=20210628_QEF2_C18_folatePColeCSF_NK508.raw
SUBJECT_SAMPLE_FACTORS           	-	NK509	Sample source:Human CSF | Timepoint:F3	RAW_FILE_NAME()=20210628_QEF2_C18_folatePColeCSF_NK509.raw
SUBJECT_SAMPLE_FACTORS           	-	NK510	Sample source:Human CSF | Timepoint:F4	RAW_FILE_NAME()=20210628_QEF2_C18_folatePColeCSF_NK510.raw
SUBJECT_SAMPLE_FACTORS           	-	NK511	Sample source:Human CSF | Timepoint:F0	RAW_FILE_NAME()=20210628_QEF2_C18_folatePColeCSF_NK511.raw
SUBJECT_SAMPLE_FACTORS           	-	NK512	Sample source:Human CSF | Timepoint:F1	RAW_FILE_NAME()=20210628_QEF2_C18_folatePColeCSF_NK512.raw
SUBJECT_SAMPLE_FACTORS           	-	NK513	Sample source:Human CSF | Timepoint:F2	RAW_FILE_NAME()=20210628_QEF2_C18_folatePColeCSF_NK513.raw
SUBJECT_SAMPLE_FACTORS           	-	NK514	Sample source:Human CSF | Timepoint:F3	RAW_FILE_NAME()=20210628_QEF2_C18_folatePColeCSF_NK514.raw
SUBJECT_SAMPLE_FACTORS           	-	NK515	Sample source:Human CSF | Timepoint:F4	RAW_FILE_NAME()=20210628_QEF2_C18_folatePColeCSF_NK515.raw
SUBJECT_SAMPLE_FACTORS           	-	NK516	Sample source:Human CSF | Timepoint:F0	RAW_FILE_NAME()=20210628_QEF2_C18_folatePColeCSF_NK516.raw
SUBJECT_SAMPLE_FACTORS           	-	NK517	Sample source:Human CSF | Timepoint:F1	RAW_FILE_NAME()=20210628_QEF2_C18_folatePColeCSF_NK517.raw
SUBJECT_SAMPLE_FACTORS           	-	NK518	Sample source:Human CSF | Timepoint:F2	RAW_FILE_NAME()=20210628_QEF2_C18_folatePColeCSF_NK518.raw
SUBJECT_SAMPLE_FACTORS           	-	NK519	Sample source:Human CSF | Timepoint:F3	RAW_FILE_NAME()=20210628_QEF2_C18_folatePColeCSF_NK519.raw
SUBJECT_SAMPLE_FACTORS           	-	NK520	Sample source:Human CSF | Timepoint:F4	RAW_FILE_NAME()=20210628_QEF2_C18_folatePColeCSF_NK520.raw
SUBJECT_SAMPLE_FACTORS           	-	NK521	Sample source:Human CSF | Timepoint:F0	RAW_FILE_NAME()=20210628_QEF2_C18_folatePColeCSF_NK521.raw
SUBJECT_SAMPLE_FACTORS           	-	NK522	Sample source:Human CSF | Timepoint:F1	RAW_FILE_NAME()=20210628_QEF2_C18_folatePColeCSF_NK522.raw
SUBJECT_SAMPLE_FACTORS           	-	NK523	Sample source:Human CSF | Timepoint:F2	RAW_FILE_NAME()=20210628_QEF2_C18_folatePColeCSF_NK523.raw
SUBJECT_SAMPLE_FACTORS           	-	NK524	Sample source:Human CSF | Timepoint:F3	RAW_FILE_NAME()=20210628_QEF2_C18_folatePColeCSF_NK524.raw
SUBJECT_SAMPLE_FACTORS           	-	NK525	Sample source:Human CSF | Timepoint:F4	RAW_FILE_NAME()=20210628_QEF2_C18_folatePColeCSF_NK525.raw
SUBJECT_SAMPLE_FACTORS           	-	NK531	Sample source:Human CSF | Timepoint:F0	RAW_FILE_NAME()=20210628_QEF2_C18_folatePColeCSF_NK531.raw
SUBJECT_SAMPLE_FACTORS           	-	NK532	Sample source:Human CSF | Timepoint:F1	RAW_FILE_NAME()=20210628_QEF2_C18_folatePColeCSF_NK532.raw
SUBJECT_SAMPLE_FACTORS           	-	NK533	Sample source:Human CSF | Timepoint:F2	RAW_FILE_NAME()=20210628_QEF2_C18_folatePColeCSF_NK533.raw
SUBJECT_SAMPLE_FACTORS           	-	NK534	Sample source:Human CSF | Timepoint:F3	RAW_FILE_NAME()=20210628_QEF2_C18_folatePColeCSF_NK534.raw
SUBJECT_SAMPLE_FACTORS           	-	NK535	Sample source:Human CSF | Timepoint:F4	RAW_FILE_NAME()=20210628_QEF2_C18_folatePColeCSF_NK535.raw
SUBJECT_SAMPLE_FACTORS           	-	NK536	Sample source:Human CSF | Timepoint:F0	RAW_FILE_NAME()=20210628_QEF2_C18_folatePColeCSF_NK536.raw
SUBJECT_SAMPLE_FACTORS           	-	NK537	Sample source:Human CSF | Timepoint:F1	RAW_FILE_NAME()=20210628_QEF2_C18_folatePColeCSF_NK537.raw
SUBJECT_SAMPLE_FACTORS           	-	NK538	Sample source:Human CSF | Timepoint:F2	RAW_FILE_NAME()=20210628_QEF2_C18_folatePColeCSF_NK538.raw
SUBJECT_SAMPLE_FACTORS           	-	NK539	Sample source:Human CSF | Timepoint:F3	RAW_FILE_NAME()=20210628_QEF2_C18_folatePColeCSF_NK539.raw
SUBJECT_SAMPLE_FACTORS           	-	NK540	Sample source:Human CSF | Timepoint:F4	RAW_FILE_NAME()=20210628_QEF2_C18_folatePColeCSF_NK540.raw
SUBJECT_SAMPLE_FACTORS           	-	NK541	Sample source:Human CSF | Timepoint:F0	RAW_FILE_NAME()=20210628_QEF2_C18_folatePColeCSF_NK541.raw
SUBJECT_SAMPLE_FACTORS           	-	NK542	Sample source:Human CSF | Timepoint:F1	RAW_FILE_NAME()=20210628_QEF2_C18_folatePColeCSF_NK542.raw
SUBJECT_SAMPLE_FACTORS           	-	NK543	Sample source:Human CSF | Timepoint:F2	RAW_FILE_NAME()=20210628_QEF2_C18_folatePColeCSF_NK543.raw
SUBJECT_SAMPLE_FACTORS           	-	NK544	Sample source:Human CSF | Timepoint:F3	RAW_FILE_NAME()=20210628_QEF2_C18_folatePColeCSF_NK544.raw
SUBJECT_SAMPLE_FACTORS           	-	NK545	Sample source:Human CSF | Timepoint:F4	RAW_FILE_NAME()=20210628_QEF2_C18_folatePColeCSF_NK545.raw
SUBJECT_SAMPLE_FACTORS           	-	NK546	Sample source:Human CSF | Timepoint:F0	RAW_FILE_NAME()=20210628_QEF2_C18_folatePColeCSF_NK546.raw
SUBJECT_SAMPLE_FACTORS           	-	NK547	Sample source:Human CSF | Timepoint:F1	RAW_FILE_NAME()=20210628_QEF2_C18_folatePColeCSF_NK547.raw
SUBJECT_SAMPLE_FACTORS           	-	NK548	Sample source:Human CSF | Timepoint:F2	RAW_FILE_NAME()=20210628_QEF2_C18_folatePColeCSF_NK548.raw
SUBJECT_SAMPLE_FACTORS           	-	NK549	Sample source:Human CSF | Timepoint:F3	RAW_FILE_NAME()=20210628_QEF2_C18_folatePColeCSF_NK549.raw
SUBJECT_SAMPLE_FACTORS           	-	NK550	Sample source:Human CSF | Timepoint:F4	RAW_FILE_NAME()=20210628_QEF2_C18_folatePColeCSF_NK550.raw
SUBJECT_SAMPLE_FACTORS           	-	NK551	Sample source:Human CSF | Timepoint:F0	RAW_FILE_NAME()=20210628_QEF2_C18_folatePColeCSF_NK551.raw
SUBJECT_SAMPLE_FACTORS           	-	NK552	Sample source:Human CSF | Timepoint:F1	RAW_FILE_NAME()=20210628_QEF2_C18_folatePColeCSF_NK552.raw
SUBJECT_SAMPLE_FACTORS           	-	NK553	Sample source:Human CSF | Timepoint:F2	RAW_FILE_NAME()=20210628_QEF2_C18_folatePColeCSF_NK553.raw
SUBJECT_SAMPLE_FACTORS           	-	NK554	Sample source:Human CSF | Timepoint:F3	RAW_FILE_NAME()=20210628_QEF2_C18_folatePColeCSF_NK554.raw
SUBJECT_SAMPLE_FACTORS           	-	NK555	Sample source:Human CSF | Timepoint:F4	RAW_FILE_NAME()=20210628_QEF2_C18_folatePColeCSF_NK555.raw
SUBJECT_SAMPLE_FACTORS           	-	NK556	Sample source:Human CSF | Timepoint:F0	RAW_FILE_NAME()=20210628_QEF2_C18_folatePColeCSF_NK556.raw
SUBJECT_SAMPLE_FACTORS           	-	NK557	Sample source:Human CSF | Timepoint:F1	RAW_FILE_NAME()=20210628_QEF2_C18_folatePColeCSF_NK557.raw
SUBJECT_SAMPLE_FACTORS           	-	NK558	Sample source:Human CSF | Timepoint:F2	RAW_FILE_NAME()=20210628_QEF2_C18_folatePColeCSF_NK558.raw
SUBJECT_SAMPLE_FACTORS           	-	NK559	Sample source:Human CSF | Timepoint:F3	RAW_FILE_NAME()=20210628_QEF2_C18_folatePColeCSF_NK559.raw
SUBJECT_SAMPLE_FACTORS           	-	NK560	Sample source:Human CSF | Timepoint:F4	RAW_FILE_NAME()=20210628_QEF2_C18_folatePColeCSF_NK560.raw
SUBJECT_SAMPLE_FACTORS           	-	NK561	Sample source:Human CSF | Timepoint:F0	RAW_FILE_NAME()=20210628_QEF2_C18_folatePColeCSF_NK561.raw
SUBJECT_SAMPLE_FACTORS           	-	NK562	Sample source:Human CSF | Timepoint:F1	RAW_FILE_NAME()=20210628_QEF2_C18_folatePColeCSF_NK562.raw
SUBJECT_SAMPLE_FACTORS           	-	NK563	Sample source:Human CSF | Timepoint:F2	RAW_FILE_NAME()=20210628_QEF2_C18_folatePColeCSF_NK563.raw
SUBJECT_SAMPLE_FACTORS           	-	NK564	Sample source:Human CSF | Timepoint:F3	RAW_FILE_NAME()=20210628_QEF2_C18_folatePColeCSF_NK564.raw
SUBJECT_SAMPLE_FACTORS           	-	NK565	Sample source:Human CSF | Timepoint:F4	RAW_FILE_NAME()=20210628_QEF2_C18_folatePColeCSF_NK565.raw
SUBJECT_SAMPLE_FACTORS           	-	NK566	Sample source:Human CSF | Timepoint:F0	RAW_FILE_NAME()=20210628_QEF2_C18_folatePColeCSF_NK566.raw
SUBJECT_SAMPLE_FACTORS           	-	NK567	Sample source:Human CSF | Timepoint:F1	RAW_FILE_NAME()=20210628_QEF2_C18_folatePColeCSF_NK567.raw
SUBJECT_SAMPLE_FACTORS           	-	NK568	Sample source:Human CSF | Timepoint:F2	RAW_FILE_NAME()=20210628_QEF2_C18_folatePColeCSF_NK568.raw
SUBJECT_SAMPLE_FACTORS           	-	NK569	Sample source:Human CSF | Timepoint:F3	RAW_FILE_NAME()=20210628_QEF2_C18_folatePColeCSF_NK569.raw
SUBJECT_SAMPLE_FACTORS           	-	NK570	Sample source:Human CSF | Timepoint:F4	RAW_FILE_NAME()=20210628_QEF2_C18_folatePColeCSF_NK570.raw
SUBJECT_SAMPLE_FACTORS           	-	NK571	Sample source:Human CSF | Timepoint:F0	RAW_FILE_NAME()=20210628_QEF2_C18_folatePColeCSF_NK571.raw
SUBJECT_SAMPLE_FACTORS           	-	NK572	Sample source:Human CSF | Timepoint:F1	RAW_FILE_NAME()=20210628_QEF2_C18_folatePColeCSF_NK572.raw
SUBJECT_SAMPLE_FACTORS           	-	NK573	Sample source:Human CSF | Timepoint:F2	RAW_FILE_NAME()=20210628_QEF2_C18_folatePColeCSF_NK573.raw
SUBJECT_SAMPLE_FACTORS           	-	NK574	Sample source:Human CSF | Timepoint:F3	RAW_FILE_NAME()=20210628_QEF2_C18_folatePColeCSF_NK574.raw
SUBJECT_SAMPLE_FACTORS           	-	NK575	Sample source:Human CSF | Timepoint:F4	RAW_FILE_NAME()=20210628_QEF2_C18_folatePColeCSF_NK575.raw
SUBJECT_SAMPLE_FACTORS           	-	AYW170	Sample source:Human CSF | Timepoint:F0	RAW_FILE_NAME()=20210923_QEF1_C18_PCole_CSF_Batch2_AYW170.raw
SUBJECT_SAMPLE_FACTORS           	-	AYW171	Sample source:Human CSF | Timepoint:F1	RAW_FILE_NAME()=20210923_QEF1_C18_PCole_CSF_Batch2_AYW171.raw
SUBJECT_SAMPLE_FACTORS           	-	AYW172	Sample source:Human CSF | Timepoint:F2	RAW_FILE_NAME()=20210923_QEF1_C18_PCole_CSF_Batch2_AYW172.raw
SUBJECT_SAMPLE_FACTORS           	-	AYW173	Sample source:Human CSF | Timepoint:F3	RAW_FILE_NAME()=20210923_QEF1_C18_PCole_CSF_Batch2_AYW173.raw
SUBJECT_SAMPLE_FACTORS           	-	AYW174	Sample source:Human CSF | Timepoint:F4	RAW_FILE_NAME()=20210923_QEF1_C18_PCole_CSF_Batch2_AYW174.raw
SUBJECT_SAMPLE_FACTORS           	-	AYW175	Sample source:Human CSF | Timepoint:F0	RAW_FILE_NAME()=20210923_QEF1_C18_PCole_CSF_Batch2_AYW175.raw
SUBJECT_SAMPLE_FACTORS           	-	AYW176	Sample source:Human CSF | Timepoint:F1	RAW_FILE_NAME()=20210923_QEF1_C18_PCole_CSF_Batch2_AYW176.raw
SUBJECT_SAMPLE_FACTORS           	-	AYW177	Sample source:Human CSF | Timepoint:F2	RAW_FILE_NAME()=20210923_QEF1_C18_PCole_CSF_Batch2_AYW177.raw
SUBJECT_SAMPLE_FACTORS           	-	AYW178	Sample source:Human CSF | Timepoint:F3	RAW_FILE_NAME()=20210923_QEF1_C18_PCole_CSF_Batch2_AYW178.raw
SUBJECT_SAMPLE_FACTORS           	-	AYW179	Sample source:Human CSF | Timepoint:F4	RAW_FILE_NAME()=20210923_QEF1_C18_PCole_CSF_Batch2_AYW179.raw
SUBJECT_SAMPLE_FACTORS           	-	AYW180	Sample source:Human CSF | Timepoint:F0	RAW_FILE_NAME()=20210923_QEF1_C18_PCole_CSF_Batch2_AYW180.raw
SUBJECT_SAMPLE_FACTORS           	-	AYW181	Sample source:Human CSF | Timepoint:F1	RAW_FILE_NAME()=20210923_QEF1_C18_PCole_CSF_Batch2_AYW181.raw
SUBJECT_SAMPLE_FACTORS           	-	AYW182	Sample source:Human CSF | Timepoint:F2	RAW_FILE_NAME()=20210923_QEF1_C18_PCole_CSF_Batch2_AYW182.raw
SUBJECT_SAMPLE_FACTORS           	-	AYW183	Sample source:Human CSF | Timepoint:F3	RAW_FILE_NAME()=20210923_QEF1_C18_PCole_CSF_Batch2_AYW183.raw
SUBJECT_SAMPLE_FACTORS           	-	AYW184	Sample source:Human CSF | Timepoint:F4	RAW_FILE_NAME()=20210923_QEF1_C18_PCole_CSF_Batch2_AYW184.raw
SUBJECT_SAMPLE_FACTORS           	-	AYW185	Sample source:Human CSF | Timepoint:F0	RAW_FILE_NAME()=20210923_QEF1_C18_PCole_CSF_Batch2_AYW185.raw
SUBJECT_SAMPLE_FACTORS           	-	AYW186	Sample source:Human CSF | Timepoint:F1	RAW_FILE_NAME()=20210923_QEF1_C18_PCole_CSF_Batch2_AYW186.raw
SUBJECT_SAMPLE_FACTORS           	-	AYW187	Sample source:Human CSF | Timepoint:F2	RAW_FILE_NAME()=20210923_QEF1_C18_PCole_CSF_Batch2_AYW187.raw
SUBJECT_SAMPLE_FACTORS           	-	AYW188	Sample source:Human CSF | Timepoint:F3	RAW_FILE_NAME()=20210923_QEF1_C18_PCole_CSF_Batch2_AYW188.raw
SUBJECT_SAMPLE_FACTORS           	-	AYW189	Sample source:Human CSF | Timepoint:F4	RAW_FILE_NAME()=20210923_QEF1_C18_PCole_CSF_Batch2_AYW189.raw
SUBJECT_SAMPLE_FACTORS           	-	AYW190	Sample source:Human CSF | Timepoint:F0	RAW_FILE_NAME()=20210923_QEF1_C18_PCole_CSF_Batch2_AYW190.raw
SUBJECT_SAMPLE_FACTORS           	-	AYW191	Sample source:Human CSF | Timepoint:F1	RAW_FILE_NAME()=20210923_QEF1_C18_PCole_CSF_Batch2_AYW191.raw
SUBJECT_SAMPLE_FACTORS           	-	AYW192	Sample source:Human CSF | Timepoint:F2	RAW_FILE_NAME()=20210923_QEF1_C18_PCole_CSF_Batch2_AYW192.raw
SUBJECT_SAMPLE_FACTORS           	-	AYW193	Sample source:Human CSF | Timepoint:F3	RAW_FILE_NAME()=20210923_QEF1_C18_PCole_CSF_Batch2_AYW193.raw
SUBJECT_SAMPLE_FACTORS           	-	AYW194	Sample source:Human CSF | Timepoint:F4	RAW_FILE_NAME()=20210923_QEF1_C18_PCole_CSF_Batch2_AYW194.raw
SUBJECT_SAMPLE_FACTORS           	-	AYW200	Sample source:Human CSF | Timepoint:F0	RAW_FILE_NAME()=20210923_QEF1_C18_PCole_CSF_Batch2_AYW200.raw
SUBJECT_SAMPLE_FACTORS           	-	AYW201	Sample source:Human CSF | Timepoint:F1	RAW_FILE_NAME()=20210923_QEF1_C18_PCole_CSF_Batch2_AYW201.raw
SUBJECT_SAMPLE_FACTORS           	-	AYW202	Sample source:Human CSF | Timepoint:F2	RAW_FILE_NAME()=20210923_QEF1_C18_PCole_CSF_Batch2_AYW202.raw
SUBJECT_SAMPLE_FACTORS           	-	AYW203	Sample source:Human CSF | Timepoint:F3	RAW_FILE_NAME()=20210923_QEF1_C18_PCole_CSF_Batch2_AYW203.raw
SUBJECT_SAMPLE_FACTORS           	-	AYW204	Sample source:Human CSF | Timepoint:F4	RAW_FILE_NAME()=20210923_QEF1_C18_PCole_CSF_Batch2_AYW204.raw
SUBJECT_SAMPLE_FACTORS           	-	AYW205	Sample source:Human CSF | Timepoint:F0	RAW_FILE_NAME()=20210923_QEF1_C18_PCole_CSF_Batch2_AYW205.raw
SUBJECT_SAMPLE_FACTORS           	-	AYW206	Sample source:Human CSF | Timepoint:F1	RAW_FILE_NAME()=20210923_QEF1_C18_PCole_CSF_Batch2_AYW206.raw
SUBJECT_SAMPLE_FACTORS           	-	AYW207	Sample source:Human CSF | Timepoint:F2	RAW_FILE_NAME()=20210923_QEF1_C18_PCole_CSF_Batch2_AYW207.raw
SUBJECT_SAMPLE_FACTORS           	-	AYW208	Sample source:Human CSF | Timepoint:F3	RAW_FILE_NAME()=20210923_QEF1_C18_PCole_CSF_Batch2_AYW208.raw
SUBJECT_SAMPLE_FACTORS           	-	AYW209	Sample source:Human CSF | Timepoint:F4	RAW_FILE_NAME()=20210923_QEF1_C18_PCole_CSF_Batch2_AYW209.raw
SUBJECT_SAMPLE_FACTORS           	-	AYW210	Sample source:Human CSF | Timepoint:F0	RAW_FILE_NAME()=20210923_QEF1_C18_PCole_CSF_Batch2_AYW210.raw
SUBJECT_SAMPLE_FACTORS           	-	AYW211	Sample source:Human CSF | Timepoint:F1	RAW_FILE_NAME()=20210923_QEF1_C18_PCole_CSF_Batch2_AYW211.raw
SUBJECT_SAMPLE_FACTORS           	-	AYW212	Sample source:Human CSF | Timepoint:F2	RAW_FILE_NAME()=20210923_QEF1_C18_PCole_CSF_Batch2_AYW212.raw
SUBJECT_SAMPLE_FACTORS           	-	AYW213	Sample source:Human CSF | Timepoint:F3	RAW_FILE_NAME()=20210923_QEF1_C18_PCole_CSF_Batch2_AYW213.raw
SUBJECT_SAMPLE_FACTORS           	-	AYW214	Sample source:Human CSF | Timepoint:F4	RAW_FILE_NAME()=20210923_QEF1_C18_PCole_CSF_Batch2_AYW214.raw
SUBJECT_SAMPLE_FACTORS           	-	AYW215	Sample source:Human CSF | Timepoint:F0	RAW_FILE_NAME()=20210923_QEF1_C18_PCole_CSF_Batch2_AYW215.raw
SUBJECT_SAMPLE_FACTORS           	-	AYW216	Sample source:Human CSF | Timepoint:F1	RAW_FILE_NAME()=20210923_QEF1_C18_PCole_CSF_Batch2_AYW216.raw
SUBJECT_SAMPLE_FACTORS           	-	AYW217	Sample source:Human CSF | Timepoint:F2	RAW_FILE_NAME()=20210923_QEF1_C18_PCole_CSF_Batch2_AYW217.raw
SUBJECT_SAMPLE_FACTORS           	-	AYW218	Sample source:Human CSF | Timepoint:F3	RAW_FILE_NAME()=20210923_QEF1_C18_PCole_CSF_Batch2_AYW218.raw
SUBJECT_SAMPLE_FACTORS           	-	AYW219	Sample source:Human CSF | Timepoint:F4	RAW_FILE_NAME()=20210923_QEF1_C18_PCole_CSF_Batch2_AYW219.raw
SUBJECT_SAMPLE_FACTORS           	-	AYW220	Sample source:Human CSF | Timepoint:F0	RAW_FILE_NAME()=20210923_QEF1_C18_PCole_CSF_Batch2_AYW220.raw
SUBJECT_SAMPLE_FACTORS           	-	AYW221	Sample source:Human CSF | Timepoint:F1	RAW_FILE_NAME()=20210923_QEF1_C18_PCole_CSF_Batch2_AYW221.raw
SUBJECT_SAMPLE_FACTORS           	-	AYW222	Sample source:Human CSF | Timepoint:F2	RAW_FILE_NAME()=20210923_QEF1_C18_PCole_CSF_Batch2_AYW222.raw
SUBJECT_SAMPLE_FACTORS           	-	AYW223	Sample source:Human CSF | Timepoint:F3	RAW_FILE_NAME()=20210923_QEF1_C18_PCole_CSF_Batch2_AYW223.raw
SUBJECT_SAMPLE_FACTORS           	-	AYW224	Sample source:Human CSF | Timepoint:F4	RAW_FILE_NAME()=20210923_QEF1_C18_PCole_CSF_Batch2_AYW224.raw
SUBJECT_SAMPLE_FACTORS           	-	AYW225	Sample source:Human CSF | Timepoint:F0	RAW_FILE_NAME()=20210923_QEF1_C18_PCole_CSF_Batch2_AYW225.raw
SUBJECT_SAMPLE_FACTORS           	-	AYW226	Sample source:Human CSF | Timepoint:F1	RAW_FILE_NAME()=20210923_QEF1_C18_PCole_CSF_Batch2_AYW226.raw
SUBJECT_SAMPLE_FACTORS           	-	AYW227	Sample source:Human CSF | Timepoint:F2	RAW_FILE_NAME()=20210923_QEF1_C18_PCole_CSF_Batch2_AYW227.raw
SUBJECT_SAMPLE_FACTORS           	-	AYW228	Sample source:Human CSF | Timepoint:F3	RAW_FILE_NAME()=20210923_QEF1_C18_PCole_CSF_Batch2_AYW228.raw
SUBJECT_SAMPLE_FACTORS           	-	AYW229	Sample source:Human CSF | Timepoint:F4	RAW_FILE_NAME()=20210923_QEF1_C18_PCole_CSF_Batch2_AYW229.raw
SUBJECT_SAMPLE_FACTORS           	-	AYW234	Sample source:Human CSF | Timepoint:F0	RAW_FILE_NAME()=20211005_C18_folates_PCole_CSF_Batch3_AYW234.raw
SUBJECT_SAMPLE_FACTORS           	-	AYW235	Sample source:Human CSF | Timepoint:F1	RAW_FILE_NAME()=20211005_C18_folates_PCole_CSF_Batch3_AYW235.raw
SUBJECT_SAMPLE_FACTORS           	-	AYW236	Sample source:Human CSF | Timepoint:F2	RAW_FILE_NAME()=20211005_C18_folates_PCole_CSF_Batch3_AYW236.raw
SUBJECT_SAMPLE_FACTORS           	-	AYW237	Sample source:Human CSF | Timepoint:F3	RAW_FILE_NAME()=20211005_C18_folates_PCole_CSF_Batch3_AYW237.raw
SUBJECT_SAMPLE_FACTORS           	-	AYW238	Sample source:Human CSF | Timepoint:F4	RAW_FILE_NAME()=20211005_C18_folates_PCole_CSF_Batch3_AYW238.raw
SUBJECT_SAMPLE_FACTORS           	-	AYW239	Sample source:Human CSF | Timepoint:F0	RAW_FILE_NAME()=20211005_C18_folates_PCole_CSF_Batch3_AYW239.raw
SUBJECT_SAMPLE_FACTORS           	-	AYW240	Sample source:Human CSF | Timepoint:F1	RAW_FILE_NAME()=20211005_C18_folates_PCole_CSF_Batch3_AYW240.raw
SUBJECT_SAMPLE_FACTORS           	-	AYW241	Sample source:Human CSF | Timepoint:F2	RAW_FILE_NAME()=20211005_C18_folates_PCole_CSF_Batch3_AYW241.raw
SUBJECT_SAMPLE_FACTORS           	-	AYW242	Sample source:Human CSF | Timepoint:F3	RAW_FILE_NAME()=20211005_C18_folates_PCole_CSF_Batch3_AYW242.raw
SUBJECT_SAMPLE_FACTORS           	-	AYW243	Sample source:Human CSF | Timepoint:F4	RAW_FILE_NAME()=20211005_C18_folates_PCole_CSF_Batch3_AYW243.raw
SUBJECT_SAMPLE_FACTORS           	-	AYW244	Sample source:Human CSF | Timepoint:F0	RAW_FILE_NAME()=20211005_C18_folates_PCole_CSF_Batch3_AYW244.raw
SUBJECT_SAMPLE_FACTORS           	-	AYW245	Sample source:Human CSF | Timepoint:F1	RAW_FILE_NAME()=20211005_C18_folates_PCole_CSF_Batch3_AYW245.raw
SUBJECT_SAMPLE_FACTORS           	-	AYW246	Sample source:Human CSF | Timepoint:F2	RAW_FILE_NAME()=20211005_C18_folates_PCole_CSF_Batch3_AYW246.raw
SUBJECT_SAMPLE_FACTORS           	-	AYW247	Sample source:Human CSF | Timepoint:F3	RAW_FILE_NAME()=20211005_C18_folates_PCole_CSF_Batch3_AYW247.raw
SUBJECT_SAMPLE_FACTORS           	-	AYW248	Sample source:Human CSF | Timepoint:F4	RAW_FILE_NAME()=20211005_C18_folates_PCole_CSF_Batch3_AYW248.raw
SUBJECT_SAMPLE_FACTORS           	-	AYW249	Sample source:Human CSF | Timepoint:F0	RAW_FILE_NAME()=20211005_C18_folates_PCole_CSF_Batch3_AYW249.raw
SUBJECT_SAMPLE_FACTORS           	-	AYW250	Sample source:Human CSF | Timepoint:F1	RAW_FILE_NAME()=20211005_C18_folates_PCole_CSF_Batch3_AYW250.raw
SUBJECT_SAMPLE_FACTORS           	-	AYW251	Sample source:Human CSF | Timepoint:F2	RAW_FILE_NAME()=20211005_C18_folates_PCole_CSF_Batch3_AYW251.raw
SUBJECT_SAMPLE_FACTORS           	-	AYW252	Sample source:Human CSF | Timepoint:F3	RAW_FILE_NAME()=20211005_C18_folates_PCole_CSF_Batch3_AYW252.raw
SUBJECT_SAMPLE_FACTORS           	-	AYW253	Sample source:Human CSF | Timepoint:F4	RAW_FILE_NAME()=20211005_C18_folates_PCole_CSF_Batch3_AYW253.raw
SUBJECT_SAMPLE_FACTORS           	-	AYW254	Sample source:Human CSF | Timepoint:F0	RAW_FILE_NAME()=20211005_C18_folates_PCole_CSF_Batch3_AYW254.raw
SUBJECT_SAMPLE_FACTORS           	-	AYW255	Sample source:Human CSF | Timepoint:F1	RAW_FILE_NAME()=20211005_C18_folates_PCole_CSF_Batch3_AYW255.raw
SUBJECT_SAMPLE_FACTORS           	-	AYW256	Sample source:Human CSF | Timepoint:F2	RAW_FILE_NAME()=20211005_C18_folates_PCole_CSF_Batch3_AYW256.raw
SUBJECT_SAMPLE_FACTORS           	-	AYW257	Sample source:Human CSF | Timepoint:F3	RAW_FILE_NAME()=20211005_C18_folates_PCole_CSF_Batch3_AYW257.raw
SUBJECT_SAMPLE_FACTORS           	-	AYW258	Sample source:Human CSF | Timepoint:F4	RAW_FILE_NAME()=20211005_C18_folates_PCole_CSF_Batch3_AYW258.raw
SUBJECT_SAMPLE_FACTORS           	-	AYW259	Sample source:Human CSF | Timepoint:F0	RAW_FILE_NAME()=20211005_C18_folates_PCole_CSF_Batch3_AYW259.raw
SUBJECT_SAMPLE_FACTORS           	-	AYW260	Sample source:Human CSF | Timepoint:F1	RAW_FILE_NAME()=20211005_C18_folates_PCole_CSF_Batch3_AYW260.raw
SUBJECT_SAMPLE_FACTORS           	-	AYW261	Sample source:Human CSF | Timepoint:F2	RAW_FILE_NAME()=20211005_C18_folates_PCole_CSF_Batch3_AYW261.raw
SUBJECT_SAMPLE_FACTORS           	-	AYW262	Sample source:Human CSF | Timepoint:F3	RAW_FILE_NAME()=20211005_C18_folates_PCole_CSF_Batch3_AYW262.raw
SUBJECT_SAMPLE_FACTORS           	-	AYW263	Sample source:Human CSF | Timepoint:F4	RAW_FILE_NAME()=20211005_C18_folates_PCole_CSF_Batch3_AYW263.raw
SUBJECT_SAMPLE_FACTORS           	-	AYW264	Sample source:Human CSF | Timepoint:F0	RAW_FILE_NAME()=20211005_C18_folates_PCole_CSF_Batch3_AYW264.raw
SUBJECT_SAMPLE_FACTORS           	-	AYW265	Sample source:Human CSF | Timepoint:F1	RAW_FILE_NAME()=20211005_C18_folates_PCole_CSF_Batch3_AYW265.raw
SUBJECT_SAMPLE_FACTORS           	-	AYW266	Sample source:Human CSF | Timepoint:F2	RAW_FILE_NAME()=20211005_C18_folates_PCole_CSF_Batch3_AYW266.raw
SUBJECT_SAMPLE_FACTORS           	-	AYW267	Sample source:Human CSF | Timepoint:F3	RAW_FILE_NAME()=20211005_C18_folates_PCole_CSF_Batch3_AYW267.raw
SUBJECT_SAMPLE_FACTORS           	-	AYW268	Sample source:Human CSF | Timepoint:F4	RAW_FILE_NAME()=20211005_C18_folates_PCole_CSF_Batch3_AYW268.raw
SUBJECT_SAMPLE_FACTORS           	-	AYW269	Sample source:Human CSF | Timepoint:F0	RAW_FILE_NAME()=20211005_C18_folates_PCole_CSF_Batch3_AYW269.raw
SUBJECT_SAMPLE_FACTORS           	-	AYW270	Sample source:Human CSF | Timepoint:F1	RAW_FILE_NAME()=20211005_C18_folates_PCole_CSF_Batch3_AYW270.raw
SUBJECT_SAMPLE_FACTORS           	-	AYW271	Sample source:Human CSF | Timepoint:F2	RAW_FILE_NAME()=20211005_C18_folates_PCole_CSF_Batch3_AYW271.raw
SUBJECT_SAMPLE_FACTORS           	-	AYW272	Sample source:Human CSF | Timepoint:F3	RAW_FILE_NAME()=20211005_C18_folates_PCole_CSF_Batch3_AYW272.raw
SUBJECT_SAMPLE_FACTORS           	-	AYW273	Sample source:Human CSF | Timepoint:F4	RAW_FILE_NAME()=20211005_C18_folates_PCole_CSF_Batch3_AYW273.raw
SUBJECT_SAMPLE_FACTORS           	-	AYW274	Sample source:Human CSF | Timepoint:F0	RAW_FILE_NAME()=20211005_C18_folates_PCole_CSF_Batch3_AYW274.raw
SUBJECT_SAMPLE_FACTORS           	-	AYW275	Sample source:Human CSF | Timepoint:F1	RAW_FILE_NAME()=20211005_C18_folates_PCole_CSF_Batch3_AYW275.raw
SUBJECT_SAMPLE_FACTORS           	-	AYW276	Sample source:Human CSF | Timepoint:F2	RAW_FILE_NAME()=20211005_C18_folates_PCole_CSF_Batch3_AYW276.raw
SUBJECT_SAMPLE_FACTORS           	-	AYW277	Sample source:Human CSF | Timepoint:F3	RAW_FILE_NAME()=20211005_C18_folates_PCole_CSF_Batch3_AYW277.raw
SUBJECT_SAMPLE_FACTORS           	-	AYW278	Sample source:Human CSF | Timepoint:F4	RAW_FILE_NAME()=20211005_C18_folates_PCole_CSF_Batch3_AYW278.raw
SUBJECT_SAMPLE_FACTORS           	-	AYW279	Sample source:Human CSF | Timepoint:F0	RAW_FILE_NAME()=20211005_C18_folates_PCole_CSF_Batch3_AYW279.raw
SUBJECT_SAMPLE_FACTORS           	-	AYW280	Sample source:Human CSF | Timepoint:F1	RAW_FILE_NAME()=20211005_C18_folates_PCole_CSF_Batch3_AYW280.raw
SUBJECT_SAMPLE_FACTORS           	-	AYW281	Sample source:Human CSF | Timepoint:F2	RAW_FILE_NAME()=20211005_C18_folates_PCole_CSF_Batch3_AYW281.raw
SUBJECT_SAMPLE_FACTORS           	-	AYW282	Sample source:Human CSF | Timepoint:F3	RAW_FILE_NAME()=20211005_C18_folates_PCole_CSF_Batch3_AYW282.raw
SUBJECT_SAMPLE_FACTORS           	-	AYW283	Sample source:Human CSF | Timepoint:F4	RAW_FILE_NAME()=20211005_C18_folates_PCole_CSF_Batch3_AYW283.raw
SUBJECT_SAMPLE_FACTORS           	-	AYW284	Sample source:Human CSF | Timepoint:F0	RAW_FILE_NAME()=20211005_C18_folates_PCole_CSF_Batch3_AYW284.raw
SUBJECT_SAMPLE_FACTORS           	-	AYW285	Sample source:Human CSF | Timepoint:F1	RAW_FILE_NAME()=20211005_C18_folates_PCole_CSF_Batch3_AYW285.raw
SUBJECT_SAMPLE_FACTORS           	-	AYW286	Sample source:Human CSF | Timepoint:F2	RAW_FILE_NAME()=20211005_C18_folates_PCole_CSF_Batch3_AYW286.raw
SUBJECT_SAMPLE_FACTORS           	-	AYW287	Sample source:Human CSF | Timepoint:F3	RAW_FILE_NAME()=20211005_C18_folates_PCole_CSF_Batch3_AYW287.raw
SUBJECT_SAMPLE_FACTORS           	-	AYW288	Sample source:Human CSF | Timepoint:F4	RAW_FILE_NAME()=20211005_C18_folates_PCole_CSF_Batch3_AYW288.raw
SUBJECT_SAMPLE_FACTORS           	-	AYW289	Sample source:Human CSF | Timepoint:F0	RAW_FILE_NAME()=20211005_C18_folates_PCole_CSF_Batch3_AYW289.raw
SUBJECT_SAMPLE_FACTORS           	-	AYW290	Sample source:Human CSF | Timepoint:F1	RAW_FILE_NAME()=20211005_C18_folates_PCole_CSF_Batch3_AYW290.raw
SUBJECT_SAMPLE_FACTORS           	-	AYW291	Sample source:Human CSF | Timepoint:F2	RAW_FILE_NAME()=20211005_C18_folates_PCole_CSF_Batch3_AYW291.raw
SUBJECT_SAMPLE_FACTORS           	-	AYW292	Sample source:Human CSF | Timepoint:F3	RAW_FILE_NAME()=20211005_C18_folates_PCole_CSF_Batch3_AYW292.raw
SUBJECT_SAMPLE_FACTORS           	-	AYW293	Sample source:Human CSF | Timepoint:F4	RAW_FILE_NAME()=20211005_C18_folates_PCole_CSF_Batch3_AYW293.raw
SUBJECT_SAMPLE_FACTORS           	-	AYW298	Sample source:Human CSF | Timepoint:F0	RAW_FILE_NAME()=20211202_QEF2_C18_PatientCSF_PCole_Batch4_AYW298.raw
SUBJECT_SAMPLE_FACTORS           	-	AYW299	Sample source:Human CSF | Timepoint:F1	RAW_FILE_NAME()=20211202_QEF2_C18_PatientCSF_PCole_Batch4_AYW299.raw
SUBJECT_SAMPLE_FACTORS           	-	AYW300	Sample source:Human CSF | Timepoint:F2	RAW_FILE_NAME()=20211202_QEF2_C18_PatientCSF_PCole_Batch4_AYW300.raw
SUBJECT_SAMPLE_FACTORS           	-	AYW301	Sample source:Human CSF | Timepoint:F3	RAW_FILE_NAME()=20211202_QEF2_C18_PatientCSF_PCole_Batch4_AYW301.raw
SUBJECT_SAMPLE_FACTORS           	-	AYW302	Sample source:Human CSF | Timepoint:F4	RAW_FILE_NAME()=20211202_QEF2_C18_PatientCSF_PCole_Batch4_AYW302.raw
SUBJECT_SAMPLE_FACTORS           	-	AYW303	Sample source:Human CSF | Timepoint:F0	RAW_FILE_NAME()=20211202_QEF2_C18_PatientCSF_PCole_Batch4_AYW303.raw
SUBJECT_SAMPLE_FACTORS           	-	AYW304	Sample source:Human CSF | Timepoint:F1	RAW_FILE_NAME()=20211202_QEF2_C18_PatientCSF_PCole_Batch4_AYW304.raw
SUBJECT_SAMPLE_FACTORS           	-	AYW305	Sample source:Human CSF | Timepoint:F2	RAW_FILE_NAME()=20211202_QEF2_C18_PatientCSF_PCole_Batch4_AYW305.raw
SUBJECT_SAMPLE_FACTORS           	-	AYW306	Sample source:Human CSF | Timepoint:F3	RAW_FILE_NAME()=20211202_QEF2_C18_PatientCSF_PCole_Batch4_AYW306.raw
SUBJECT_SAMPLE_FACTORS           	-	AYW307	Sample source:Human CSF | Timepoint:F4	RAW_FILE_NAME()=20211202_QEF2_C18_PatientCSF_PCole_Batch4_AYW307.raw
SUBJECT_SAMPLE_FACTORS           	-	AYW308	Sample source:Human CSF | Timepoint:F0	RAW_FILE_NAME()=20211202_QEF2_C18_PatientCSF_PCole_Batch4_AYW308.raw
SUBJECT_SAMPLE_FACTORS           	-	AYW309	Sample source:Human CSF | Timepoint:F1	RAW_FILE_NAME()=20211202_QEF2_C18_PatientCSF_PCole_Batch4_AYW309.raw
SUBJECT_SAMPLE_FACTORS           	-	AYW310	Sample source:Human CSF | Timepoint:F2	RAW_FILE_NAME()=20211202_QEF2_C18_PatientCSF_PCole_Batch4_AYW310.raw
SUBJECT_SAMPLE_FACTORS           	-	AYW311	Sample source:Human CSF | Timepoint:F3	RAW_FILE_NAME()=20211202_QEF2_C18_PatientCSF_PCole_Batch4_AYW311.raw
SUBJECT_SAMPLE_FACTORS           	-	AYW312	Sample source:Human CSF | Timepoint:F4	RAW_FILE_NAME()=20211202_QEF2_C18_PatientCSF_PCole_Batch4_AYW312.raw
SUBJECT_SAMPLE_FACTORS           	-	AYW313	Sample source:Human CSF | Timepoint:F0	RAW_FILE_NAME()=20211202_QEF2_C18_PatientCSF_PCole_Batch4_AYW313.raw
SUBJECT_SAMPLE_FACTORS           	-	AYW314	Sample source:Human CSF | Timepoint:F1	RAW_FILE_NAME()=20211202_QEF2_C18_PatientCSF_PCole_Batch4_AYW314.raw
SUBJECT_SAMPLE_FACTORS           	-	AYW315	Sample source:Human CSF | Timepoint:F2	RAW_FILE_NAME()=20211202_QEF2_C18_PatientCSF_PCole_Batch4_AYW315.raw
SUBJECT_SAMPLE_FACTORS           	-	AYW316	Sample source:Human CSF | Timepoint:F3	RAW_FILE_NAME()=20211202_QEF2_C18_PatientCSF_PCole_Batch4_AYW316.raw
SUBJECT_SAMPLE_FACTORS           	-	AYW317	Sample source:Human CSF | Timepoint:F4	RAW_FILE_NAME()=20211202_QEF2_C18_PatientCSF_PCole_Batch4_AYW317.raw
SUBJECT_SAMPLE_FACTORS           	-	AYW318	Sample source:Human CSF | Timepoint:F0	RAW_FILE_NAME()=20211202_QEF2_C18_PatientCSF_PCole_Batch4_AYW318.raw
SUBJECT_SAMPLE_FACTORS           	-	AYW319	Sample source:Human CSF | Timepoint:F1	RAW_FILE_NAME()=20211202_QEF2_C18_PatientCSF_PCole_Batch4_AYW319.raw
SUBJECT_SAMPLE_FACTORS           	-	AYW320	Sample source:Human CSF | Timepoint:F2	RAW_FILE_NAME()=20211202_QEF2_C18_PatientCSF_PCole_Batch4_AYW320.raw
SUBJECT_SAMPLE_FACTORS           	-	AYW321	Sample source:Human CSF | Timepoint:F3	RAW_FILE_NAME()=20211202_QEF2_C18_PatientCSF_PCole_Batch4_AYW321.raw
SUBJECT_SAMPLE_FACTORS           	-	AYW322	Sample source:Human CSF | Timepoint:F4	RAW_FILE_NAME()=20211202_QEF2_C18_PatientCSF_PCole_Batch4_AYW322.raw
SUBJECT_SAMPLE_FACTORS           	-	AYW323	Sample source:Human CSF | Timepoint:F0	RAW_FILE_NAME()=20211202_QEF2_C18_PatientCSF_PCole_Batch4_AYW323.raw
SUBJECT_SAMPLE_FACTORS           	-	AYW324	Sample source:Human CSF | Timepoint:F1	RAW_FILE_NAME()=20211202_QEF2_C18_PatientCSF_PCole_Batch4_AYW324.raw
SUBJECT_SAMPLE_FACTORS           	-	AYW325	Sample source:Human CSF | Timepoint:F2	RAW_FILE_NAME()=20211202_QEF2_C18_PatientCSF_PCole_Batch4_AYW325.raw
SUBJECT_SAMPLE_FACTORS           	-	AYW326	Sample source:Human CSF | Timepoint:F3	RAW_FILE_NAME()=20211202_QEF2_C18_PatientCSF_PCole_Batch4_AYW326.raw
SUBJECT_SAMPLE_FACTORS           	-	AYW327	Sample source:Human CSF | Timepoint:F4	RAW_FILE_NAME()=20211202_QEF2_C18_PatientCSF_PCole_Batch4_AYW327.raw
SUBJECT_SAMPLE_FACTORS           	-	AYW328	Sample source:Human CSF | Timepoint:F0	RAW_FILE_NAME()=20211202_QEF2_C18_PatientCSF_PCole_Batch4_AYW328.raw
SUBJECT_SAMPLE_FACTORS           	-	AYW329	Sample source:Human CSF | Timepoint:F1	RAW_FILE_NAME()=20211202_QEF2_C18_PatientCSF_PCole_Batch4_AYW329.raw
SUBJECT_SAMPLE_FACTORS           	-	AYW330	Sample source:Human CSF | Timepoint:F2	RAW_FILE_NAME()=20211202_QEF2_C18_PatientCSF_PCole_Batch4_AYW330.raw
SUBJECT_SAMPLE_FACTORS           	-	AYW331	Sample source:Human CSF | Timepoint:F3	RAW_FILE_NAME()=20211202_QEF2_C18_PatientCSF_PCole_Batch4_AYW331.raw
SUBJECT_SAMPLE_FACTORS           	-	AYW332	Sample source:Human CSF | Timepoint:F4	RAW_FILE_NAME()=20211202_QEF2_C18_PatientCSF_PCole_Batch4_AYW332.raw
SUBJECT_SAMPLE_FACTORS           	-	AYW333	Sample source:Human CSF | Timepoint:F0	RAW_FILE_NAME()=20211202_QEF2_C18_PatientCSF_PCole_Batch4_AYW333.raw
SUBJECT_SAMPLE_FACTORS           	-	AYW334	Sample source:Human CSF | Timepoint:F1	RAW_FILE_NAME()=20211202_QEF2_C18_PatientCSF_PCole_Batch4_AYW334.raw
SUBJECT_SAMPLE_FACTORS           	-	AYW335	Sample source:Human CSF | Timepoint:F2	RAW_FILE_NAME()=20211202_QEF2_C18_PatientCSF_PCole_Batch4_AYW335.raw
SUBJECT_SAMPLE_FACTORS           	-	AYW336	Sample source:Human CSF | Timepoint:F3	RAW_FILE_NAME()=20211202_QEF2_C18_PatientCSF_PCole_Batch4_AYW336.raw
SUBJECT_SAMPLE_FACTORS           	-	AYW337	Sample source:Human CSF | Timepoint:F4	RAW_FILE_NAME()=20211202_QEF2_C18_PatientCSF_PCole_Batch4_AYW337.raw
SUBJECT_SAMPLE_FACTORS           	-	AYW338	Sample source:Human CSF | Timepoint:F0	RAW_FILE_NAME()=20211202_QEF2_C18_PatientCSF_PCole_Batch4_AYW338.raw
SUBJECT_SAMPLE_FACTORS           	-	AYW339	Sample source:Human CSF | Timepoint:F1	RAW_FILE_NAME()=20211202_QEF2_C18_PatientCSF_PCole_Batch4_AYW339.raw
SUBJECT_SAMPLE_FACTORS           	-	AYW340	Sample source:Human CSF | Timepoint:F2	RAW_FILE_NAME()=20211202_QEF2_C18_PatientCSF_PCole_Batch4_AYW340.raw
SUBJECT_SAMPLE_FACTORS           	-	AYW341	Sample source:Human CSF | Timepoint:F3	RAW_FILE_NAME()=20211202_QEF2_C18_PatientCSF_PCole_Batch4_AYW341.raw
SUBJECT_SAMPLE_FACTORS           	-	AYW342	Sample source:Human CSF | Timepoint:F4	RAW_FILE_NAME()=20211202_QEF2_C18_PatientCSF_PCole_Batch4_AYW342.raw
SUBJECT_SAMPLE_FACTORS           	-	AYW347	Sample source:Human CSF | Timepoint:F0	RAW_FILE_NAME()=20211203_QEF2_C18_PCole_hCSF_Batch5_AYW347.raw
SUBJECT_SAMPLE_FACTORS           	-	AYW348	Sample source:Human CSF | Timepoint:F1	RAW_FILE_NAME()=20211203_QEF2_C18_PCole_hCSF_Batch5_AYW348.raw
SUBJECT_SAMPLE_FACTORS           	-	AYW349	Sample source:Human CSF | Timepoint:F2	RAW_FILE_NAME()=20211203_QEF2_C18_PCole_hCSF_Batch5_AYW349.raw
SUBJECT_SAMPLE_FACTORS           	-	AYW350	Sample source:Human CSF | Timepoint:F3	RAW_FILE_NAME()=20211203_QEF2_C18_PCole_hCSF_Batch5_AYW350.raw
SUBJECT_SAMPLE_FACTORS           	-	AYW351	Sample source:Human CSF | Timepoint:F4	RAW_FILE_NAME()=20211203_QEF2_C18_PCole_hCSF_Batch5_AYW351.raw
SUBJECT_SAMPLE_FACTORS           	-	AYW352	Sample source:Human CSF | Timepoint:F0	RAW_FILE_NAME()=20211203_QEF2_C18_PCole_hCSF_Batch5_AYW352.raw
SUBJECT_SAMPLE_FACTORS           	-	AYW353	Sample source:Human CSF | Timepoint:F1	RAW_FILE_NAME()=20211203_QEF2_C18_PCole_hCSF_Batch5_AYW353.raw
SUBJECT_SAMPLE_FACTORS           	-	AYW354	Sample source:Human CSF | Timepoint:F2	RAW_FILE_NAME()=20211203_QEF2_C18_PCole_hCSF_Batch5_AYW354.raw
SUBJECT_SAMPLE_FACTORS           	-	AYW355	Sample source:Human CSF | Timepoint:F3	RAW_FILE_NAME()=20211203_QEF2_C18_PCole_hCSF_Batch5_AYW355.raw
SUBJECT_SAMPLE_FACTORS           	-	AYW356	Sample source:Human CSF | Timepoint:F4	RAW_FILE_NAME()=20211203_QEF2_C18_PCole_hCSF_Batch5_AYW356.raw
SUBJECT_SAMPLE_FACTORS           	-	AYW357	Sample source:Human CSF | Timepoint:F0	RAW_FILE_NAME()=20211203_QEF2_C18_PCole_hCSF_Batch5_AYW357.raw
SUBJECT_SAMPLE_FACTORS           	-	AYW358	Sample source:Human CSF | Timepoint:F1	RAW_FILE_NAME()=20211203_QEF2_C18_PCole_hCSF_Batch5_AYW358.raw
SUBJECT_SAMPLE_FACTORS           	-	AYW359	Sample source:Human CSF | Timepoint:F2	RAW_FILE_NAME()=20211203_QEF2_C18_PCole_hCSF_Batch5_AYW359.raw
SUBJECT_SAMPLE_FACTORS           	-	AYW360	Sample source:Human CSF | Timepoint:F3	RAW_FILE_NAME()=20211203_QEF2_C18_PCole_hCSF_Batch5_AYW360.raw
SUBJECT_SAMPLE_FACTORS           	-	AYW361	Sample source:Human CSF | Timepoint:F4	RAW_FILE_NAME()=20211203_QEF2_C18_PCole_hCSF_Batch5_AYW361.raw
SUBJECT_SAMPLE_FACTORS           	-	AYW362	Sample source:Human CSF | Timepoint:F0	RAW_FILE_NAME()=20211203_QEF2_C18_PCole_hCSF_Batch5_AYW362.raw
SUBJECT_SAMPLE_FACTORS           	-	AYW363	Sample source:Human CSF | Timepoint:F1	RAW_FILE_NAME()=20211203_QEF2_C18_PCole_hCSF_Batch5_AYW363.raw
SUBJECT_SAMPLE_FACTORS           	-	AYW364	Sample source:Human CSF | Timepoint:F2	RAW_FILE_NAME()=20211203_QEF2_C18_PCole_hCSF_Batch5_AYW364.raw
SUBJECT_SAMPLE_FACTORS           	-	AYW365	Sample source:Human CSF | Timepoint:F3	RAW_FILE_NAME()=20211203_QEF2_C18_PCole_hCSF_Batch5_AYW365.raw
SUBJECT_SAMPLE_FACTORS           	-	AYW366	Sample source:Human CSF | Timepoint:F4	RAW_FILE_NAME()=20211203_QEF2_C18_PCole_hCSF_Batch5_AYW366.raw
SUBJECT_SAMPLE_FACTORS           	-	AYW367	Sample source:Human CSF | Timepoint:F0	RAW_FILE_NAME()=20211203_QEF2_C18_PCole_hCSF_Batch5_AYW367.raw
SUBJECT_SAMPLE_FACTORS           	-	AYW368	Sample source:Human CSF | Timepoint:F1	RAW_FILE_NAME()=20211203_QEF2_C18_PCole_hCSF_Batch5_AYW368.raw
SUBJECT_SAMPLE_FACTORS           	-	AYW369	Sample source:Human CSF | Timepoint:F2	RAW_FILE_NAME()=20211203_QEF2_C18_PCole_hCSF_Batch5_AYW369.raw
SUBJECT_SAMPLE_FACTORS           	-	AYW370	Sample source:Human CSF | Timepoint:F3	RAW_FILE_NAME()=20211203_QEF2_C18_PCole_hCSF_Batch5_AYW370.raw
SUBJECT_SAMPLE_FACTORS           	-	AYW371	Sample source:Human CSF | Timepoint:F4	RAW_FILE_NAME()=20211203_QEF2_C18_PCole_hCSF_Batch5_AYW371.raw
SUBJECT_SAMPLE_FACTORS           	-	AYW372	Sample source:Human CSF | Timepoint:F0	RAW_FILE_NAME()=20211203_QEF2_C18_PCole_hCSF_Batch5_AYW372.raw
SUBJECT_SAMPLE_FACTORS           	-	AYW373	Sample source:Human CSF | Timepoint:F1	RAW_FILE_NAME()=20211203_QEF2_C18_PCole_hCSF_Batch5_AYW373.raw
SUBJECT_SAMPLE_FACTORS           	-	AYW374	Sample source:Human CSF | Timepoint:F2	RAW_FILE_NAME()=20211203_QEF2_C18_PCole_hCSF_Batch5_AYW374.raw
SUBJECT_SAMPLE_FACTORS           	-	AYW375	Sample source:Human CSF | Timepoint:F3	RAW_FILE_NAME()=20211203_QEF2_C18_PCole_hCSF_Batch5_AYW375.raw
SUBJECT_SAMPLE_FACTORS           	-	AYW376	Sample source:Human CSF | Timepoint:F4	RAW_FILE_NAME()=20211203_QEF2_C18_PCole_hCSF_Batch5_AYW376.raw
SUBJECT_SAMPLE_FACTORS           	-	AYW377	Sample source:Human CSF | Timepoint:F0	RAW_FILE_NAME()=20211203_QEF2_C18_PCole_hCSF_Batch5_AYW377.raw
SUBJECT_SAMPLE_FACTORS           	-	AYW378	Sample source:Human CSF | Timepoint:F1	RAW_FILE_NAME()=20211203_QEF2_C18_PCole_hCSF_Batch5_AYW378.raw
SUBJECT_SAMPLE_FACTORS           	-	AYW379	Sample source:Human CSF | Timepoint:F2	RAW_FILE_NAME()=20211203_QEF2_C18_PCole_hCSF_Batch5_AYW379.raw
SUBJECT_SAMPLE_FACTORS           	-	AYW380	Sample source:Human CSF | Timepoint:F3	RAW_FILE_NAME()=20211203_QEF2_C18_PCole_hCSF_Batch5_AYW380.raw
SUBJECT_SAMPLE_FACTORS           	-	AYW381	Sample source:Human CSF | Timepoint:F4	RAW_FILE_NAME()=20211203_QEF2_C18_PCole_hCSF_Batch5_AYW381.raw
SUBJECT_SAMPLE_FACTORS           	-	AYW382	Sample source:Human CSF | Timepoint:F0	RAW_FILE_NAME()=20211203_QEF2_C18_PCole_hCSF_Batch5_AYW382.raw
SUBJECT_SAMPLE_FACTORS           	-	AYW383	Sample source:Human CSF | Timepoint:F1	RAW_FILE_NAME()=20211203_QEF2_C18_PCole_hCSF_Batch5_AYW383.raw
SUBJECT_SAMPLE_FACTORS           	-	AYW384	Sample source:Human CSF | Timepoint:F2	RAW_FILE_NAME()=20211203_QEF2_C18_PCole_hCSF_Batch5_AYW384.raw
SUBJECT_SAMPLE_FACTORS           	-	AYW385	Sample source:Human CSF | Timepoint:F3	RAW_FILE_NAME()=20211203_QEF2_C18_PCole_hCSF_Batch5_AYW385.raw
SUBJECT_SAMPLE_FACTORS           	-	AYW386	Sample source:Human CSF | Timepoint:F4	RAW_FILE_NAME()=20211203_QEF2_C18_PCole_hCSF_Batch5_AYW386.raw
SUBJECT_SAMPLE_FACTORS           	-	AYW387	Sample source:Human CSF | Timepoint:F0	RAW_FILE_NAME()=20211203_QEF2_C18_PCole_hCSF_Batch5_AYW387.raw
SUBJECT_SAMPLE_FACTORS           	-	AYW388	Sample source:Human CSF | Timepoint:F1	RAW_FILE_NAME()=20211203_QEF2_C18_PCole_hCSF_Batch5_AYW388.raw
SUBJECT_SAMPLE_FACTORS           	-	AYW389	Sample source:Human CSF | Timepoint:F2	RAW_FILE_NAME()=20211203_QEF2_C18_PCole_hCSF_Batch5_AYW389.raw
SUBJECT_SAMPLE_FACTORS           	-	AYW390	Sample source:Human CSF | Timepoint:F3	RAW_FILE_NAME()=20211203_QEF2_C18_PCole_hCSF_Batch5_AYW390.raw
SUBJECT_SAMPLE_FACTORS           	-	AYW391	Sample source:Human CSF | Timepoint:F4	RAW_FILE_NAME()=20211203_QEF2_C18_PCole_hCSF_Batch5_AYW391.raw
SUBJECT_SAMPLE_FACTORS           	-	AYW392	Sample source:Human CSF | Timepoint:F0	RAW_FILE_NAME()=20211203_QEF2_C18_PCole_hCSF_Batch5_AYW392.raw
SUBJECT_SAMPLE_FACTORS           	-	AYW393	Sample source:Human CSF | Timepoint:F1	RAW_FILE_NAME()=20211203_QEF2_C18_PCole_hCSF_Batch5_AYW393.raw
SUBJECT_SAMPLE_FACTORS           	-	AYW394	Sample source:Human CSF | Timepoint:F2	RAW_FILE_NAME()=20211203_QEF2_C18_PCole_hCSF_Batch5_AYW394.raw
SUBJECT_SAMPLE_FACTORS           	-	AYW395	Sample source:Human CSF | Timepoint:F3	RAW_FILE_NAME()=20211203_QEF2_C18_PCole_hCSF_Batch5_AYW395.raw
SUBJECT_SAMPLE_FACTORS           	-	AYW396	Sample source:Human CSF | Timepoint:F4	RAW_FILE_NAME()=20211203_QEF2_C18_PCole_hCSF_Batch5_AYW396.raw
#COLLECTION
CO:COLLECTION_SUMMARY            	Excess human CSF during planned lumbar punctures was collected and kept on ice.
CO:COLLECTION_SUMMARY            	Human CSF was aliquoted and stored at -80C. Samples were thawed once and
CO:COLLECTION_SUMMARY            	re-aliquoted into 20uL aliquots and refrozen at -80C.
CO:SAMPLE_TYPE                   	Cerebrospinal fluid
#TREATMENT
TR:TREATMENT_SUMMARY             	Human CSF samples were collected from patients enrolled in the DFCI 16-001
TR:TREATMENT_SUMMARY             	trial. Briefly, the lumbar puncture timepoints from which CSF was collected were
TR:TREATMENT_SUMMARY             	as follows: F0 = lumbar puncture from the day of diagnosis (LP), F1 = day 18 of
TR:TREATMENT_SUMMARY             	induction LP (induction is the phase in which intensive systemic and intrathecal
TR:TREATMENT_SUMMARY             	chemotherapy is given to induce remission and kill most cancer cells. If
TR:TREATMENT_SUMMARY             	successful, the patient proceeds to the first consolidation phase (Consolidation
TR:TREATMENT_SUMMARY             	1A) in which additional therapy is given to eradicate residual disease), F2 =
TR:TREATMENT_SUMMARY             	central nervous system (CNS) phase LP 1 - (the 3-week CNS phase of therapy
TR:TREATMENT_SUMMARY             	follows Consolidation 1A, and consists of therapy directed to the CNS through
TR:TREATMENT_SUMMARY             	intrathecal administration. This helps to kill any cancer cells that are in the
TR:TREATMENT_SUMMARY             	CNS, and to prevent subsequent spread of cancer into the CNS). This first LP is
TR:TREATMENT_SUMMARY             	at the beginning of the CNS phase. F3 = CNS Phase LP 4 - this is the last LP
TR:TREATMENT_SUMMARY             	during the CNS phase, F4 = 1st LP of Consolidation II - this phase follows the
TR:TREATMENT_SUMMARY             	CNS phase and consists of additional therapy to ensure durable remission
#SAMPLEPREP
SP:SAMPLEPREP_SUMMARY            	Each sample contained 20uL of human CSF. 160uL of 100% LC-MS grade methanol
SP:SAMPLEPREP_SUMMARY            	supplemented with isotopically-labelled amino acid standards [Cambridge Isotope
SP:SAMPLEPREP_SUMMARY            	Laboratories, MSK-A2-1.2], aminopterin, and reduced glutathione standard
SP:SAMPLEPREP_SUMMARY            	[Cambridge Isotope Laboratories, CNLM-6245-10]). with repeated pipetting up and
SP:SAMPLEPREP_SUMMARY            	down and vortexing for 10 seconds. Then, 40uL of LCMS-grade water containing 125
SP:SAMPLEPREP_SUMMARY            	mM Ammonium Acetate, 10 mM Na-Ascorbate, and 7.9 mg/mL
SP:SAMPLEPREP_SUMMARY            	5,5-dithio-bis-(2-nitrobenzoic acid (Ellman's reagent) was added, and the sample
SP:SAMPLEPREP_SUMMARY            	vortexex for another 10 seconds. Samples were then centrifuged for 10 minutes at
SP:SAMPLEPREP_SUMMARY            	18,000 g to pellet debris. The supernatant was transferred to a new tube and
SP:SAMPLEPREP_SUMMARY            	dried on ice using a liquid nitrogen dryer and stored at -80C. The dried
SP:SAMPLEPREP_SUMMARY            	metabolites were then resuspended in 15uL and 10uL was injected.
#CHROMATOGRAPHY
CH:CHROMATOGRAPHY_SUMMARY        	5 μl was injected onto a Ascentis Express C18 HPLC column
CH:CHROMATOGRAPHY_SUMMARY        	(2.7 μm × 15 cm × 2.1 mm; Sigma Aldrich). The column oven and
CH:CHROMATOGRAPHY_SUMMARY        	autosampler tray were held at 30 °C and 4 °C, respectively. The following
CH:CHROMATOGRAPHY_SUMMARY        	conditions were used to achieve chromatographic separation: buffer A was 0.1%
CH:CHROMATOGRAPHY_SUMMARY        	formic acid in water; buffer B was acetonitrile with 0.1% formic acid. The
CH:CHROMATOGRAPHY_SUMMARY        	chromatographic gradient was run at a flow rate of 0.250 ml min−1 as
CH:CHROMATOGRAPHY_SUMMARY        	follows: 0–5 min: gradient was held at 5% B; 5–10 min: linear gradient
CH:CHROMATOGRAPHY_SUMMARY        	of 5% to 36% B; 10.1–14.0 min: linear gradient from 36–95% B;
CH:CHROMATOGRAPHY_SUMMARY        	14.1–18.0 min: gradient was returned to 5% B.
CH:CHROMATOGRAPHY_TYPE           	Reversed phase
CH:INSTRUMENT_NAME               	Thermo Vanquish
CH:COLUMN_NAME                   	Merck Supelco Ascentis Express C18 (150 x 2.1mm,2.7um)
CH:SOLVENT_A                     	100% water; 0.1% formic acid
CH:SOLVENT_B                     	100% acetonitrile; 0.1% formic acid
CH:FLOW_GRADIENT                 	0–5 min: gradient was held at 5% B; 5–10 min: linear gradient from 5% to
CH:FLOW_GRADIENT                 	36% B; 10.1–14.0 min: linear gradient from 36–95% B; 14.1–18.0 min:
CH:FLOW_GRADIENT                 	gradient was returned to 5% B.
CH:FLOW_RATE                     	0.25 mL/min
CH:COLUMN_TEMPERATURE            	30
#ANALYSIS
AN:ANALYSIS_TYPE                 	MS
#MS
MS:INSTRUMENT_NAME               	Thermo Q Exactive Orbitrap
MS:INSTRUMENT_TYPE               	Orbitrap
MS:MS_TYPE                       	ESI
MS:ION_MODE                      	POSITIVE
MS:MS_COMMENTS                   	The mass spectrometer was operated in full-scan, positive ionization mode using
MS:MS_COMMENTS                   	three narrow-range scans: 438–450 m/z; 452–462 m/z; and 470–478 m/z, with
MS:MS_COMMENTS                   	the resolution set at 70,000, the AGC target at 10e6, and the maximum injection
MS:MS_COMMENTS                   	time of 150 ms. HESI settings were: sheath gas flow rate: 40; Aux gas flow
MS:MS_COMMENTS                   	rate: 10; Sweep gas: 0; Spray voltage: 2.8 (neg) 3.5 (pos); Capillary
MS:MS_COMMENTS                   	temperature 300; S-lens RF level 50; Aux gas heater temp: 350.
#MS_METABOLITE_DATA
MS_METABOLITE_DATA:UNITS	Normalized peak area
MS_METABOLITE_DATA_START
Samples	NK496	NK497	NK498	NK499	NK500	NK501	NK502	NK503	NK504	NK505	NK506	NK507	NK508	NK509	NK510	NK511	NK512	NK513	NK514	NK515	NK516	NK517	NK518	NK519	NK520	NK521	NK522	NK523	NK524	NK525	NK531	NK532	NK533	NK534	NK535	NK536	NK537	NK538	NK539	NK540	NK541	NK542	NK543	NK544	NK545	NK546	NK547	NK548	NK549	NK550	NK551	NK552	NK553	NK554	NK555	NK556	NK557	NK558	NK559	NK560	NK561	NK562	NK563	NK564	NK565	NK566	NK567	NK568	NK569	NK570	NK571	NK572	NK573	NK574	NK575	AYW170	AYW171	AYW172	AYW173	AYW174	AYW175	AYW176	AYW177	AYW178	AYW179	AYW180	AYW181	AYW182	AYW183	AYW184	AYW185	AYW186	AYW187	AYW188	AYW189	AYW190	AYW191	AYW192	AYW193	AYW194	AYW200	AYW201	AYW202	AYW203	AYW204	AYW205	AYW206	AYW207	AYW208	AYW209	AYW210	AYW211	AYW212	AYW213	AYW214	AYW215	AYW216	AYW217	AYW218	AYW219	AYW220	AYW221	AYW222	AYW223	AYW224	AYW225	AYW226	AYW227	AYW228	AYW229	AYW234	AYW235	AYW236	AYW237	AYW238	AYW239	AYW240	AYW241	AYW242	AYW243	AYW244	AYW245	AYW246	AYW247	AYW248	AYW249	AYW250	AYW251	AYW252	AYW253	AYW254	AYW255	AYW256	AYW257	AYW258	AYW259	AYW260	AYW261	AYW262	AYW263	AYW264	AYW265	AYW266	AYW267	AYW268	AYW269	AYW270	AYW271	AYW272	AYW273	AYW274	AYW275	AYW276	AYW277	AYW278	AYW279	AYW280	AYW281	AYW282	AYW283	AYW284	AYW285	AYW286	AYW287	AYW288	AYW289	AYW290	AYW291	AYW292	AYW293	AYW298	AYW299	AYW300	AYW301	AYW302	AYW303	AYW304	AYW305	AYW306	AYW307	AYW308	AYW309	AYW310	AYW311	AYW312	AYW313	AYW314	AYW315	AYW316	AYW317	AYW318	AYW319	AYW320	AYW321	AYW322	AYW323	AYW324	AYW325	AYW326	AYW327	AYW328	AYW329	AYW330	AYW331	AYW332	AYW333	AYW334	AYW335	AYW336	AYW337	AYW338	AYW339	AYW340	AYW341	AYW342	AYW347	AYW348	AYW349	AYW350	AYW351	AYW352	AYW353	AYW354	AYW355	AYW356	AYW357	AYW358	AYW359	AYW360	AYW361	AYW362	AYW363	AYW364	AYW365	AYW366	AYW367	AYW368	AYW369	AYW370	AYW371	AYW372	AYW373	AYW374	AYW375	AYW376	AYW377	AYW378	AYW379	AYW380	AYW381	AYW382	AYW383	AYW384	AYW385	AYW386	AYW387	AYW388	AYW389	AYW390	AYW391	AYW392	AYW393	AYW394	AYW395	AYW396
Factors	Sample source:Human CSF | Timepoint:F0	Sample source:Human CSF | Timepoint:F1	Sample source:Human CSF | Timepoint:F2	Sample source:Human CSF | Timepoint:F3	Sample source:Human CSF | Timepoint:F4	Sample source:Human CSF | Timepoint:F0	Sample source:Human CSF | Timepoint:F1	Sample source:Human CSF | Timepoint:F2	Sample source:Human CSF | Timepoint:F3	Sample source:Human CSF | Timepoint:F4	Sample source:Human CSF | Timepoint:F0	Sample source:Human CSF | Timepoint:F1	Sample source:Human CSF | Timepoint:F2	Sample source:Human CSF | Timepoint:F3	Sample source:Human CSF | Timepoint:F4	Sample source:Human CSF | Timepoint:F0	Sample source:Human CSF | Timepoint:F1	Sample source:Human CSF | Timepoint:F2	Sample source:Human CSF | Timepoint:F3	Sample source:Human CSF | Timepoint:F4	Sample source:Human CSF | Timepoint:F0	Sample source:Human CSF | Timepoint:F1	Sample source:Human CSF | Timepoint:F2	Sample source:Human CSF | Timepoint:F3	Sample source:Human CSF | Timepoint:F4	Sample source:Human CSF | Timepoint:F0	Sample source:Human CSF | Timepoint:F1	Sample source:Human CSF | Timepoint:F2	Sample source:Human CSF | Timepoint:F3	Sample source:Human CSF | Timepoint:F4	Sample source:Human CSF | Timepoint:F0	Sample source:Human CSF | Timepoint:F1	Sample source:Human CSF | Timepoint:F2	Sample source:Human CSF | Timepoint:F3	Sample source:Human CSF | Timepoint:F4	Sample source:Human CSF | Timepoint:F0	Sample source:Human CSF | Timepoint:F1	Sample source:Human CSF | Timepoint:F2	Sample source:Human CSF | Timepoint:F3	Sample source:Human CSF | Timepoint:F4	Sample source:Human CSF | Timepoint:F0	Sample source:Human CSF | Timepoint:F1	Sample source:Human CSF | Timepoint:F2	Sample source:Human CSF | Timepoint:F3	Sample source:Human CSF | Timepoint:F4	Sample source:Human CSF | Timepoint:F0	Sample source:Human CSF | Timepoint:F1	Sample source:Human CSF | Timepoint:F2	Sample source:Human CSF | Timepoint:F3	Sample source:Human CSF | Timepoint:F4	Sample source:Human CSF | Timepoint:F0	Sample source:Human CSF | Timepoint:F1	Sample source:Human CSF | Timepoint:F2	Sample source:Human CSF | Timepoint:F3	Sample source:Human CSF | Timepoint:F4	Sample source:Human CSF | Timepoint:F0	Sample source:Human CSF | Timepoint:F1	Sample source:Human CSF | Timepoint:F2	Sample source:Human CSF | Timepoint:F3	Sample source:Human CSF | Timepoint:F4	Sample source:Human CSF | Timepoint:F0	Sample source:Human CSF | Timepoint:F1	Sample source:Human CSF | Timepoint:F2	Sample source:Human CSF | Timepoint:F3	Sample source:Human CSF | Timepoint:F4	Sample source:Human CSF | Timepoint:F0	Sample source:Human CSF | Timepoint:F1	Sample source:Human CSF | Timepoint:F2	Sample source:Human CSF | Timepoint:F3	Sample source:Human CSF | Timepoint:F4	Sample source:Human CSF | Timepoint:F0	Sample source:Human CSF | Timepoint:F1	Sample source:Human CSF | Timepoint:F2	Sample source:Human CSF | Timepoint:F3	Sample source:Human CSF | Timepoint:F4	Sample source:Human CSF | Timepoint:F0	Sample source:Human CSF | Timepoint:F1	Sample source:Human CSF | Timepoint:F2	Sample source:Human CSF | Timepoint:F3	Sample source:Human CSF | Timepoint:F4	Sample source:Human CSF | Timepoint:F0	Sample source:Human CSF | Timepoint:F1	Sample source:Human CSF | Timepoint:F2	Sample source:Human CSF | Timepoint:F3	Sample source:Human CSF | Timepoint:F4	Sample source:Human CSF | Timepoint:F0	Sample source:Human CSF | Timepoint:F1	Sample source:Human CSF | Timepoint:F2	Sample source:Human CSF | Timepoint:F3	Sample source:Human CSF | Timepoint:F4	Sample source:Human CSF | Timepoint:F0	Sample source:Human CSF | Timepoint:F1	Sample source:Human CSF | Timepoint:F2	Sample source:Human CSF | Timepoint:F3	Sample source:Human CSF | Timepoint:F4	Sample source:Human CSF | Timepoint:F0	Sample source:Human CSF | Timepoint:F1	Sample source:Human CSF | Timepoint:F2	Sample source:Human CSF | Timepoint:F3	Sample source:Human CSF | Timepoint:F4	Sample source:Human CSF | Timepoint:F0	Sample source:Human CSF | Timepoint:F1	Sample source:Human CSF | Timepoint:F2	Sample source:Human CSF | Timepoint:F3	Sample source:Human CSF | Timepoint:F4	Sample source:Human CSF | Timepoint:F0	Sample source:Human CSF | Timepoint:F1	Sample source:Human CSF | Timepoint:F2	Sample source:Human CSF | Timepoint:F3	Sample source:Human CSF | Timepoint:F4	Sample source:Human CSF | Timepoint:F0	Sample source:Human CSF | Timepoint:F1	Sample source:Human CSF | Timepoint:F2	Sample source:Human CSF | Timepoint:F3	Sample source:Human CSF | Timepoint:F4	Sample source:Human CSF | Timepoint:F0	Sample source:Human CSF | Timepoint:F1	Sample source:Human CSF | Timepoint:F2	Sample source:Human CSF | Timepoint:F3	Sample source:Human CSF | Timepoint:F4	Sample source:Human CSF | Timepoint:F0	Sample source:Human CSF | Timepoint:F1	Sample source:Human CSF | Timepoint:F2	Sample source:Human CSF | Timepoint:F3	Sample source:Human CSF | Timepoint:F4	Sample source:Human CSF | Timepoint:F0	Sample source:Human CSF | Timepoint:F1	Sample source:Human CSF | Timepoint:F2	Sample source:Human CSF | Timepoint:F3	Sample source:Human CSF | Timepoint:F4	Sample source:Human CSF | Timepoint:F0	Sample source:Human CSF | Timepoint:F1	Sample source:Human CSF | Timepoint:F2	Sample source:Human CSF | Timepoint:F3	Sample source:Human CSF | Timepoint:F4	Sample source:Human CSF | Timepoint:F0	Sample source:Human CSF | Timepoint:F1	Sample source:Human CSF | Timepoint:F2	Sample source:Human CSF | Timepoint:F3	Sample source:Human CSF | Timepoint:F4	Sample source:Human CSF | Timepoint:F0	Sample source:Human CSF | Timepoint:F1	Sample source:Human CSF | Timepoint:F2	Sample source:Human CSF | Timepoint:F3	Sample source:Human CSF | Timepoint:F4	Sample source:Human CSF | Timepoint:F0	Sample source:Human CSF | Timepoint:F1	Sample source:Human CSF | Timepoint:F2	Sample source:Human CSF | Timepoint:F3	Sample source:Human CSF | Timepoint:F4	Sample source:Human CSF | Timepoint:F0	Sample source:Human CSF | Timepoint:F1	Sample source:Human CSF | Timepoint:F2	Sample source:Human CSF | Timepoint:F3	Sample source:Human CSF | Timepoint:F4	Sample source:Human CSF | Timepoint:F0	Sample source:Human CSF | Timepoint:F1	Sample source:Human CSF | Timepoint:F2	Sample source:Human CSF | Timepoint:F3	Sample source:Human CSF | Timepoint:F4	Sample source:Human CSF | Timepoint:F0	Sample source:Human CSF | Timepoint:F1	Sample source:Human CSF | Timepoint:F2	Sample source:Human CSF | Timepoint:F3	Sample source:Human CSF | Timepoint:F4	Sample source:Human CSF | Timepoint:F0	Sample source:Human CSF | Timepoint:F1	Sample source:Human CSF | Timepoint:F2	Sample source:Human CSF | Timepoint:F3	Sample source:Human CSF | Timepoint:F4	Sample source:Human CSF | Timepoint:F0	Sample source:Human CSF | Timepoint:F1	Sample source:Human CSF | Timepoint:F2	Sample source:Human CSF | Timepoint:F3	Sample source:Human CSF | Timepoint:F4	Sample source:Human CSF | Timepoint:F0	Sample source:Human CSF | Timepoint:F1	Sample source:Human CSF | Timepoint:F2	Sample source:Human CSF | Timepoint:F3	Sample source:Human CSF | Timepoint:F4	Sample source:Human CSF | Timepoint:F0	Sample source:Human CSF | Timepoint:F1	Sample source:Human CSF | Timepoint:F2	Sample source:Human CSF | Timepoint:F3	Sample source:Human CSF | Timepoint:F4	Sample source:Human CSF | Timepoint:F0	Sample source:Human CSF | Timepoint:F1	Sample source:Human CSF | Timepoint:F2	Sample source:Human CSF | Timepoint:F3	Sample source:Human CSF | Timepoint:F4	Sample source:Human CSF | Timepoint:F0	Sample source:Human CSF | Timepoint:F1	Sample source:Human CSF | Timepoint:F2	Sample source:Human CSF | Timepoint:F3	Sample source:Human CSF | Timepoint:F4	Sample source:Human CSF | Timepoint:F0	Sample source:Human CSF | Timepoint:F1	Sample source:Human CSF | Timepoint:F2	Sample source:Human CSF | Timepoint:F3	Sample source:Human CSF | Timepoint:F4	Sample source:Human CSF | Timepoint:F0	Sample source:Human CSF | Timepoint:F1	Sample source:Human CSF | Timepoint:F2	Sample source:Human CSF | Timepoint:F3	Sample source:Human CSF | Timepoint:F4	Sample source:Human CSF | Timepoint:F0	Sample source:Human CSF | Timepoint:F1	Sample source:Human CSF | Timepoint:F2	Sample source:Human CSF | Timepoint:F3	Sample source:Human CSF | Timepoint:F4	Sample source:Human CSF | Timepoint:F0	Sample source:Human CSF | Timepoint:F1	Sample source:Human CSF | Timepoint:F2	Sample source:Human CSF | Timepoint:F3	Sample source:Human CSF | Timepoint:F4	Sample source:Human CSF | Timepoint:F0	Sample source:Human CSF | Timepoint:F1	Sample source:Human CSF | Timepoint:F2	Sample source:Human CSF | Timepoint:F3	Sample source:Human CSF | Timepoint:F4	Sample source:Human CSF | Timepoint:F0	Sample source:Human CSF | Timepoint:F1	Sample source:Human CSF | Timepoint:F2	Sample source:Human CSF | Timepoint:F3	Sample source:Human CSF | Timepoint:F4	Sample source:Human CSF | Timepoint:F0	Sample source:Human CSF | Timepoint:F1	Sample source:Human CSF | Timepoint:F2	Sample source:Human CSF | Timepoint:F3	Sample source:Human CSF | Timepoint:F4	Sample source:Human CSF | Timepoint:F0	Sample source:Human CSF | Timepoint:F1	Sample source:Human CSF | Timepoint:F2	Sample source:Human CSF | Timepoint:F3	Sample source:Human CSF | Timepoint:F4	Sample source:Human CSF | Timepoint:F0	Sample source:Human CSF | Timepoint:F1	Sample source:Human CSF | Timepoint:F2	Sample source:Human CSF | Timepoint:F3	Sample source:Human CSF | Timepoint:F4	Sample source:Human CSF | Timepoint:F0	Sample source:Human CSF | Timepoint:F1	Sample source:Human CSF | Timepoint:F2	Sample source:Human CSF | Timepoint:F3	Sample source:Human CSF | Timepoint:F4	Sample source:Human CSF | Timepoint:F0	Sample source:Human CSF | Timepoint:F1	Sample source:Human CSF | Timepoint:F2	Sample source:Human CSF | Timepoint:F3	Sample source:Human CSF | Timepoint:F4	Sample source:Human CSF | Timepoint:F0	Sample source:Human CSF | Timepoint:F1	Sample source:Human CSF | Timepoint:F2	Sample source:Human CSF | Timepoint:F3	Sample source:Human CSF | Timepoint:F4	Sample source:Human CSF | Timepoint:F0	Sample source:Human CSF | Timepoint:F1	Sample source:Human CSF | Timepoint:F2	Sample source:Human CSF | Timepoint:F3	Sample source:Human CSF | Timepoint:F4	Sample source:Human CSF | Timepoint:F0	Sample source:Human CSF | Timepoint:F1	Sample source:Human CSF | Timepoint:F2	Sample source:Human CSF | Timepoint:F3	Sample source:Human CSF | Timepoint:F4	Sample source:Human CSF | Timepoint:F0	Sample source:Human CSF | Timepoint:F1	Sample source:Human CSF | Timepoint:F2	Sample source:Human CSF | Timepoint:F3	Sample source:Human CSF | Timepoint:F4	Sample source:Human CSF | Timepoint:F0	Sample source:Human CSF | Timepoint:F1	Sample source:Human CSF | Timepoint:F2	Sample source:Human CSF | Timepoint:F3	Sample source:Human CSF | Timepoint:F4	Sample source:Human CSF | Timepoint:F0	Sample source:Human CSF | Timepoint:F1	Sample source:Human CSF | Timepoint:F2	Sample source:Human CSF | Timepoint:F3	Sample source:Human CSF | Timepoint:F4	Sample source:Human CSF | Timepoint:F0	Sample source:Human CSF | Timepoint:F1	Sample source:Human CSF | Timepoint:F2	Sample source:Human CSF | Timepoint:F3	Sample source:Human CSF | Timepoint:F4
10-formyl-THF	61219.10319	70980.43763	67514.89017	21403.38084	97805.36446	66265.8815	51515.57534	86420.26726	31992.23847	73737.88623	65632.48167	82502.35443	84333.54138	46369.45243	64034.93338	61437.41507	55148.72754	170731.5872	50190.02971	104546.1583	160311.883	90200.04437	129315.4955	43726.95857	70563.79455	95098.42416	25344.01642	57887.66951	52699.1938	59818.47136	57929.40684	48851.86366	44064.7172	22505.99892	49385.65554	128745.8327	135521.6693	87440.72808	65703.8991	66156.01906	62257.26976	81430.01522	60396.63188	45081.302	89656.84768	67654.97226	65532.84955	57151.13211	39518.65207	8294.376058	52734.43806	85468.61669	89010.25274	55357.70766	102231.4185	55566.29953	65303.96322	95692.85585	32262.31771	59665.16732	35797.2733	83404.54267	94118.92461	35303.09405	67753.31491	103036.4508	37914.95855	101627.428	64560.39053	73666.2704	62808.47251	46487.94217	83760.81071	60132.5578	49379.78879	95823.01975	67218.90676	107976.5986	43362.37641	50912.98159	62786.38602	58304.03468	80726.92623	82403.58456	55232.94456	42870.05933	40540.24643	56410.64749	34201.47014	71706.63541	105964.5068	99502.1135	125576.5954	62779.41471	92878.66783	127904.4536	71422.32454	118566.0961	66938.60066	101144.7685	55400.11893	97930.34183	99612.59532	93091.40294	109193.3034	44882.40482	52785.33747	45274.56715	31739.75853	59250.21273	49198.08386	23661.87668	112421.6601	29614.44219	70009.20466	60807.68675	41566.79332	15526.5364	19749.29797	74773.57679	88840.11992	32567.20619	41416.5852	34459.18156	87338.65254	64430.88399	40172.30706	101023.591	24915.74833	61417.95272	79958.47667	33181.86615	99121.7982	39707.66202	103587.4419	98873.13779	36138.16738	69372.73339	21893.64374	24561.46837	65805.23818	51322.38854	73540.29427	26424.47926	47942.14513	92000.96746	48916.70899	81568.69064	34108.10388	75257.30735	85003.23357	53247.00918	77433.69685	45235.0339	89874.19422	96251.57527	47320.02656	141281.8556	38264.26455	72488.75048	32476.34613	18535.25992	72419.49869	33053.76689	69643.67352	91857.49609	49540.19068	75941.99582	28641.74135	60298.85902	52397.38871	29328.82034	88375.51142	25324.88241	84422.76877	37812.22875	19775.91137	55090.43916	23833.65299	11606.96171	38537.46041	28554.14952	47010.7888	17432.49997	19309.89237	73526.59555	64273.65482	80254.91895	37944.64387	45558.90773	76016.96835	71931.08734	65142.53841	26095.75235	68077.34559	64979.11956	23749.89154	45591.54527	14388.43478	16141.72085	43246.99848	33728.9146	48330.45335	17366.08583	31507.42912	60462.75053	32147.90946	53606.69055	22415.74011	49458.86903	55863.86152	34993.76932	50889.18546	29728.32401	59065.04175	63256.2368	31098.57472	92849.9974	25147.15601	47639.38204	21343.35397	12181.31534	47593.86997	21722.83311	45769.60628	60368.46159	32557.65969	49908.84417	18823.2636	39628.22317	34435.40138	19274.80978	58080.11206	16643.43419	55482.38185	24850.07948	12996.66763	36205.26579	44926.81744	88050.82915	80433.18146	42841.27549	88350.86742	42543.89789	83852.58402	53702.06971	35882.25225	63862.89072	9569.747543	13162.36177	59558.38383	49812.82262	69224.22422	35078.7194	71040.91098	78629.36781	48966.96183	122276.1329	48766.4051	107505.2347	54927.00932	38340.53917	54738.66401	31156.06771	70876.03162	86873.40641	49207.49829	70259.31499	21575.80041	37216.06368	74272.89567	39934.80341	88852.90357	53697.15339	83166.56237	94420.8474	71639.68206	94885.83437	30756.85889	94699.77695	88232.66736	69667.66393	104334.3456	45372.8799	94181.15393
5-10-methenyl-THF	30796.63192	26013.06183	358045.5806	288596.1718	250439.7334	123912.3236	54349.31547	420494.6791	179671.7403	259602.5628	37328.95163	55804.60641	181269.4959	91433.04774	110277.8749	48724.44862	59549.01244	303276.1638	188885.6625	202236.4671	334270.8981	57224.67788	316863.8813	154185.3489	148984.3455	66860.82805	#VALUE!	76029.16784	50857.37873	109097.9002	156435.835	102756.371	23910.488	63138.76154	77629.93071	114950.4084	63853.93634	139248.9221	156167.0956	118547.1516	72794.4664	115265.5664	74198.94097	103788.6942	194773.0338	165750.6035	100449.5528	153993.5618	174028.3087	14319.95078	72991.68619	165204.6575	169680.1832	107407.4899	587522.8262	136616.2742	209096.74	576006.2998	213233.9937	181431.2224	214745.7845	333392.9328	705053.635	488150.6406	343766.088	222080.3812	279345.0244	333355.2443	393988.9061	304136.0619	291784.0908	254716.8616	385681.4091	443467.4202	453150.1226	40461.85842	35654.66276	131572.3172	39312.17815	19717.37905	36911.36354	1719.969564	78789.71079	110881.9779	88793.48236	37207.75119	43694.95572	267753.5236	73278.31673	50060.38797	39570.70706	11338.81299	58630.8131	52403.07457	30431.11592	19015.38064	1729.817262	25571.70522	38631.57238	34700.55347	22548.08616	30724.9382	73083.10759	16543.25925	33903.6712	19184.51508	37895.66859	109236.9397	87514.43774	71742.69852	35272.41359	22894.00284	267159.9314	69281.1343	56806.49847	41327.76722	17742.80512	14750.55945	18845.15826	80123.09675	19866.29996	6089.193246	81031.13041	103904.1378	79445.3163	34387.89092	19414.92777	75853.17161	25121.99683	56735.38313	#VALUE!	#VALUE!	#VALUE!	#VALUE!	#VALUE!	#VALUE!	#VALUE!	#VALUE!	#VALUE!	#VALUE!	#VALUE!	#VALUE!	#VALUE!	#VALUE!	#VALUE!	#VALUE!	#VALUE!	#VALUE!	#VALUE!	#VALUE!	#VALUE!	#VALUE!	#VALUE!	#VALUE!	#VALUE!	#VALUE!	#VALUE!	#VALUE!	#VALUE!	#VALUE!	#VALUE!	#VALUE!	#VALUE!	#VALUE!	#VALUE!	#VALUE!	#VALUE!	#VALUE!	#VALUE!	#VALUE!	#VALUE!	#VALUE!	#VALUE!	#VALUE!	#VALUE!	#VALUE!	#VALUE!	#VALUE!	#VALUE!	#VALUE!	#VALUE!	#VALUE!	#VALUE!	#VALUE!	#VALUE!	#VALUE!	#VALUE!	#VALUE!	#VALUE!	#VALUE!	10472.03051	5629.903379	#VALUE!	#VALUE!	#VALUE!	#VALUE!	#VALUE!	#VALUE!	#VALUE!	#VALUE!	#VALUE!	#VALUE!	#VALUE!	#VALUE!	#VALUE!	#VALUE!	#VALUE!	#VALUE!	#VALUE!	#VALUE!	#VALUE!	#VALUE!	#VALUE!	#VALUE!	#VALUE!	#VALUE!	#VALUE!	#VALUE!	#VALUE!	#VALUE!	#VALUE!	#VALUE!	#VALUE!	#VALUE!	#VALUE!	#VALUE!	#VALUE!	#VALUE!	#VALUE!	#VALUE!	#VALUE!	#VALUE!	#VALUE!	#VALUE!	#VALUE!	#VALUE!	#VALUE!	#VALUE!	115705.8519	106143.0203	32107.52229	22478.59741	249406.2215	176887.3435	44582.08772	25837.38015	25606.73723	300806.7127	12847.31739	20724.61728	37783.67136	16494.8552	64754.7539	64484.19881	59730.47884	17080.85938	19173.8926	32570.45997	130048.6757	80700.34153	31910.02249	7087.753905	50641.56474	50880.1283	27267.2326	68031.67939	12995.76225	135517.4768	32229.89122	17611.94999	18043.63654	9968.655601	19601.99032	61145.67792	40042.1034	81694.93367	30318.28958	107804.3367	82430.87659	29037.19963	46852.5417	33367.07273	104463.8876	68885.26696	132334.9925
5-methyl-THF	2928790.02	2051324.28	5459499.067	1982717.831	5753909.454	4556541.308	2421508.008	5516984.234	1498529.676	4839013.24	2416404.394	1031196.816	4939290.555	834460.366	3475883.929	2316191.853	2652324.251	8349603.265	1213443.424	5713842.004	7547075.642	3305816.432	8079634.715	1673845.796	4023307.395	6240305.133	1578125.882	4957445.774	3690294.579	3512532.073	5393073.602	2989445.953	3613318.274	1481811.854	3691385.968	4064633.134	3865032.625	4524107.851	2174305.595	1945023.679	3341428.146	3033759.87	3438678.145	836162.4284	3017889.03	3302629.785	2344152.677	3756995.821	1605418.957	456478.5392	2850631.928	2725375.48	4448777.879	1094279.528	3664866.111	1644765.721	2313148.38	4532123.509	1086994.746	2158660.908	1883757.127	3423700.128	5099268.304	1765167.718	3581023.03	4654013.782	322597.6498	4564267.39	2091791.456	2714741.522	2618418.304	1588589.566	4289180.454	2290673.377	2157077.06	4589789.141	1995524.161	5381018.622	671133.0382	2082053.275	3134332.362	2017647.834	5035440.67	2101513.064	3419004.338	3051628.053	1448988.236	5092962.453	2584561.301	4079116.297	3588399.241	2755608.18	4467475.484	864071.38	4266408.155	3208753.52	1006819.71	3321399.976	1377405.755	2529463.385	2876443.801	3647967.635	5539103.645	4553753.213	5336779.13	2566691.071	1299885.589	2806818.068	1777630.358	2924643.832	3633029.242	1525475.786	5453295.625	1581448.799	4434066.98	3476122.434	1745065.863	1363268.773	938287.4268	5086526.951	5776951.585	1248773.214	3606548.858	1696202.165	4676397.54	4520738.355	2286949.126	7730290.94	1350786.665	3970165.32	3951204.061	717742.3499	4168446.459	1098361.021	4349443.005	4379782.764	2089495.325	5918857.52	799847.2197	1642314.39	4287366.021	2423587.846	5618146.194	856018.6824	3550210.177	5446537.951	2382114.742	5131783.551	1986343.058	6328192.878	4337038.721	2044857.299	4902552.341	1102342.146	4134052.577	4080016.427	1360044.146	5908028.511	1473737.693	2987789.792	1527923.123	1192795.769	5146677.339	1845583.438	4427291.518	4298312.493	1459550.459	3873839.988	717634.7324	2901621.308	2546557.85	1314963.901	5769174.913	447867.7433	4719505.221	2605588.044	1444320.055	3969446.246	1714726.184	724660.0743	2639652.988	1773270.146	3765203.893	1861866.364	1717013.352	4316349.812	2663680.221	4748926.087	1193153.497	1606417.279	3940852.125	3024416.669	2554699.007	673148.0991	2665625.631	2684219.837	1280580.591	3627466.389	490199.1467	1006518.611	2627580.76	1485334.53	3443170.649	524624.725	2175803.024	3337997.796	1459917.076	3145095.533	1217362.077	3878334.103	2658023.467	1253223.464	3004607.524	675587.9951	2533620.167	2500503.249	833524.7827	3620829.658	903203.689	1831114.706	936412.0956	731023.9428	3154223.429	1131095.295	2713336.336	2634289.48	894508.8159	2374144.724	439813.9105	1778304.974	1560698.661	805896.6341	3535731.012	274482.9015	2892424.172	1596876.259	885174.6197	2432738.547	2900559.884	4520408.846	4378709.437	1597359.941	6206951.837	1779779.454	4646657.879	2159124.497	1808531.209	5308348.888	255538.0325	1033027.583	2716015.984	2046375.702	3963181.833	931224.5793	3978654.28	3370255.906	1561859.683	4680142.145	1758699.522	4034075.501	2753211.752	1881860.364	3075450.192	967593.8659	3498631.824	4772663.031	1442870.619	3934653.246	520439.4248	1311987.163	2875706.438	1131569.767	3247522.843	1358561.101	3145946.199	4702252.505	1683568.861	4624672.214	813421.3748	4775264.581	4747563.853	3159456.815	5657962.999	1450115.15	4503024.731
MS_METABOLITE_DATA_END
#METABOLITES
METABOLITES_START
metabolite_name	Formula	m/z for M+H	RT
10-formyl-THF	C20H23N7O7	474.17317	2.86
5-10-methenyl-THF	C20H21N7O6+	456.16261	3.1
5-methyl-THF	C20H25N7O6	460.19391	2.93
METABOLITES_END
#END