Pilot and Feasibility Program

Pilot and Feasibility (P&F) awards are intended to provide opportunities for investigators to advance basic, clinical and translational biomedical science by incorporating metabolomic technologies into their research, and to support projects that will provide preliminary data for new extramural proposal submission. Information related to the most recent call for applications my be accessed via our Funding Opportunities page.

Funded P&F Projects 2016

Michigan Regional Comprehensive Metabolomics Resource Core (MRC2)
  • Abu-Soud, Husam, Wayne State University, "Targeted Metabolomic Analysis of Oocyte Dysfunction in Patients with Classic Galatosemia"
  • Chen, Xuequn, Wayne State University, "Lipidomics Analysis of Altered Beta Cell ER homeostatis in Diabetes"
  • Cree Green, Melanie, University of Colorado Anschutz Medical Campus, "The role of branched chain amino acid metabolism in muscle insulin resistance in youth with obesity and Polycystic ovarian syndrome"
  • Chefetz Menaker, Ilana, University of Michigan, "Cellular metabolome in necroptosis"
  • Song, Guisheng, University of Minnesota, "microRNA-206-mediated lipidome alteration prevents the progression of simple steatosis to NASH"
  • Zaghloul, Norann, University of Maryland, Baltimore, "Role of TM6SF2 in systemic and tissue lipid homeostasis"
  • Chang, Cheong-Hee, University of Michigan, "Regulation of immunity by microbiota-induced metabolic changes"
West Coast Central Comprehensive Metabolomics Resource Core (WCMC)
  • Damrauer, Scott, MD, U Pennsylvania, "Changes in Metabolites and Lipid Mediators Associated with Supervised Exercise Training for Peripheral Artery Disease"
  • Youn, Jang, PhD, U Southern California, Application of Oxylipin Metabolomics to Studies of Novel Roles of Dietary Potassium and Gut Microbiota in Postprandial Oxidative Stress"
  • Wilson, Sean, PhD , Loma Linda University, "Maternal Hypoxemia and Oxidative Stress in the Fetus, Newborn, and Adult"
  • Lange, Stephan, PhD, UC San Diego, "Inflammatory Resolution in Cardiometabolic Health and Disease"
  • Connor, Kip, PhD , Harvard University, "Epoxygenase Lipid Metabolites are Essential Second Messengers in the Attenuation of Choroidal Neovascularization"
  • Nolta, Jan, PhD, UC Davis, "Validation of Metabolic Modulation of Mesenchymal Stem Cells and their"
  • Chiu, Joanna, PhD, UC Davis, "Investigating the Cross-talk between Animal Circadian Clock and Metabolism "
  • Zivkovic, Angela, PhD, UC Davis, "The Interplay of Diet and the Gut Microbiome in Inter-Individual Differences In TMAO Production"
Eastern Regional Comprehensive Metabolomics Resource Core (ERCMRC)
  • Marek Napierala, Ph.D., University of Alabama at Birmingham, Dept. of Biochemistry & Molecular Genetics, "Metabolic Biomarkers of Friedreich's Ataxia"
  • Henry J. Kaminsky, MD, George Washington University, "Defining the Metabolomic Profile of Myasthena Gravis Treatment"
  • Anna Nolan, MD, New York University School of Medicine, "Metabolomics of the World Trade Center Exposed New York City Firefighters"
  • Brock Christensen, Geisel School of Medicine at Dartmouth, "The breast milk metabolome and its relation with maternal diet, the breast milk microbiome and the infant gut microbiome"
  • Andrea Kelly, MD, Children's Hospital of Philadelphia & Children's National Medical Center, "Metabolomics, body composition, & cardiometabolic Risk in children & adolescents with down syndrome"
  • Ling Shi, University of Massachusetts, "Metabolomic Signatures of Soy Intake among Pregnant Women at High Risk for Gestational Diabetes Mellitus"
Southeast Center for Integrated Metabolomics (SECIM)
  • Borengasser, Sarah, University of Colorado Denver, "Targeted Metabolomics for 1C Metabolites from Maternal Dried Blood Spot Samples Prior to and During Pregnancy"
  • Bril, Fernando, University of Florida, "Identification of Biomarkers Associated with the Progression of Nonalcoholic Fatty Liver Disease"
  • Ghayee, Hans, University of Florida, "Metabolic Analysis of Human PCC/PGL Cancer Cells Reveals the Importance of Chromogranin-mediated Deacidification in Cancer Survival"
  • Hartman, John Louis, University of Alabama at Birmingham, "Integration of genetic and metabolic networks that influence cellular aging"
  • Kanetsky, Peter, Moffitt Cancer Center, "Metabolomics of Cutaneous Malignant Melanoma"
  • Norton, Luke, University of Texas HSC San Antonio, "The Regulation of Hepatic Pyruvate Metabolism by Pioglitazone"
  • Pacak, Christina, "University of Florida; Washington University in St. Louis", "Human Urinary Renal Epithelial Cells as Metabolic Biomarkers for Barth Syndrome"
  • Raizada, Mohan, University of Florida, "Discovery of an Unique Bacterial Metabolic Profile in Resistant Hypertensive Patients"
  • Wohlgemuth, Stephanie, University of Florida, "Effect of early gestational heat stress on the skeletal muscle metabolome in dairy cows"
  • Luesch, Hendrik, University of Florida, "The Functional Interplay of Marine Natural Products: Marine Cyanobacterial Small Molecules as Activators of Secondary Metabolism in Marine Actinobacteria."
  • Julie A. Johnson, University of Florida, "Investigating Eicosanoids Implications on the Blood Pressure Response to Thiazide Diuretics"
Resource Center for Stable Isotope-Resolved Metabolomics (RC-SIRM)
  • Wu, Min, Massachusetts General Hospital, "Elucidating metabolic pathways associated with lung epithelial cell differentiation"
  • Biswal, Shyam, Johns Hopkins Univ, "Metabolic re-programming due to air pollution exposure"
  • Pan, Bin-Tao, University of Kentucky, "SIRM analysis of induced vacuole accumulation in cancer cells"
  • Seth, Pankaj, Beth Israel Deaconess Medical Center, "Role of 6PGD in tumor and T cell biology"
  • Hildebrandt, Gerhard, University of Kentucky, "Metabolomics of lung injury after allogeneic hematopoietic cell transplantation"
Metabolomics Core at Mayo Clinic
  • Alice Chang, M.D., Mayo Clinic, Rochester, "Mechanisms for Insulin Resistance in Polycystic Ovary Syndrom"
  • Denis C. Guttridge, Ph.D., The Ohio State University, Wexner Medical Center, "Metabolomics of Muscle Wasting in Cancer Cachexia"
  • Mora Samia, M.D., Harvard Medical School, "Experimental Validation of Metabolite Identification Through Metabomatching Using NMR Spectroscopy"
  • Charles Howe, Ph.D., Mayo Clinic, Rochester, "The pathogenic neuromyelitis optica immunoglobuli G dysregulates the astrocytic glutamine-glutamate cycle: a metabolic basis for depression in NMO patients"
  • So-Youne Chang, Ph.D., Mayo Clinic, Rochester, "Characterization of Metabolomics Profile Changes during the Development of Post-Traumatic Epilepsy"
  • Brian Hoffman, Ph.D., Medical College of Wisconsin, "The influence of Sugar, Artificial Sweeteners, and the Microbiome on Metabolism"
  • David J. Daniels, M.D., Ph.D., Mayo Clinic, Rochester, "Evaluating Glutamine Metabolism in Pediatric High Grade Gliomas with the H3K27M Mutation"
  • Steven O'Hara, Ph.D., Mayo Clinic, Rochester, "The Enterohepatic Metabolome in Primary Sclerosing Cholangitis"
  • Melissa St. Hilaire, Ph.D., Harvard Medical School, "A Pilot Study of urine metabolomics towards an outpatient estimate of circadian phase"

Funded P&F Projects 2015

Michigan Regional Comprehensive Metabolomics Resource Core (MRC2)
  • Dus, Monica, Assistant Professor, University of Michigan, "Dissecting the role of metabolites as key regulators of health and disease"
  • Halade, Ganesh, Assistant Professor (Tenure Earning), University of Alabama at Birmingham, "Cardiosplenic Metabolism of DHA and EPA Intermediates Following Myocardial Infarction in Obesity
  • Aslibekyan, Stella, Assistant Professor, University of Alabama at Birmingham, "Metabolomic Markers of Dietary Patterns in the Costa Rica Study"
West Coast Central Comprehensive Metabolomics Resource Core (WCMC)
  • Carmichael, Suzan, PhD, Stanford, "Etiologies of Preterm Delivery Among Obese Women"
  • Sundberg, John, DVM, PhD, Jackson lab, "Lipids and Cicatricial Alopecias in Mice and Humans"
  • Sarzynski, Mark, PhD, LSU Pennington, "Changes in the Metabolome and Lipidome in Response to Exercise Training"
  • Lam, Kit, MD, PhD, UC Davis, "Effect of the Tumor Microenvironment and Cancer Therapies on Exosomal Bioactive Lipid Profiles"
  • Selvaraj, Vimal, PhD, Cornell, "Unraveling a Novel Cholesterol Pathway in Metabolism and Alzheimer’s Disease"
  • Edinger, Aimee, UC Irvine, "Effect of Anti-Neoplastic Sphingolipids on the Metabolome of Normal and Cancer Cells"
  • Whiteson, Katrine, PhD, UC Irvine, "Integrative ‘Omics to Study Human-Associated Microbial Communities"
Eastern Regional Comprehensive Metabolomics Resource Core (ERCMRC)
  • Holly, Stephen P. (Co-Investigators: Leslie V. Parise, Ph.D.), University of North Carolina at Chapel Hill and RTI International, "Metabolic Profiling of Activated and AADACL1-Inhibited Human Platelets"
  • Brittain, Evan, MD MSCI, Vanderbilt University School of Medicine, "Transpulmonary Metabolomics in Pulmonary Arterial Hypertension"
  • McClenathan, Bruce M., MD (Co-Investigators: Y. Sammy Choi, MD), "Defense Health Agency-Immunization Healthcare Branch and Womack Army Medical Center, Metabotypes of Subjects with Adverse Reactions Following Vaccination: A Pilot Study"
  • Ruiz, Jimmy, MD (Co-Investigators: Michael Chan, MD), Wake Forest University Health Sciences, "Metabolomic Analysis of Patients with Brain metastasis to predict for the development of rapid brain failure after gamma knife radiosurgery"
  • Kanan, Yasmine, Ph.D. (Co-Investigators: Tammey Naab, MD; Robert L. Copeland), Howard University, "Characterizing commonalities and differences between the breast and prostate cancer metabotypes in African-American cohorts"
  • Ginsber, Stephen D., NYU Langone Medical Center, "CNS and Peripheral metabolomics of calorie restriction in a mouse model of Alzheimer's disease"
  • Merchant, Michael L., PhD (Co-Investigators: Michael E. Brier, Ph.D.), University of Louisville, "Broad Spectrum Metabolomic Analysis of Serum Samples and Identification of Markers of ESA response"
Southeast Center for Integrated Metabolomics (SECIM)
  • Triplett, Eric, University of Florida, "A metabolomics blueprint for culturing the citrus greening pathogen"
  • Seal, John, Ochsner Multi-Organ Transplant Institute, "Metabolomics Approach to Allograft Assessment in Liver Transplantation"
  • Gregory, Jesse, University of Florida, "Metabolic Consequences of Vitamin B6 Insufficiency and Associations with Cardiovascular Disease"
  • Coen, Paul, Florida Hospital, "The role of NAD+ and SIRT1/3 in mitochondrial dysfunction during disuse-induced muscle atrophy"
  • Choe, Keith, University of Florida, "Metabolic profiling of aging in a long-lived and stress resistant C. elegans mutant"
  • Musselman, Laura, Binghamton University, State University of New York, "Tissue-specific analyses of Drosophila metabolism"
  • Reed, Laura, University of Alabama, "Characterizing the metabolism of a deadly mushroom toxin in Drosophila"
  • Kenworthy, Kevin, University of Florida, "The Development of Metabolomic Markers in Bermudagrass (Cynodon spp.) for Sting Nematode (Belonolaimus longicaudatus) Response"
  • Dave, Kunjan, University of Miami, "Impact of recurrent hypoglycemia on brain metabolite profile."
  • Wing, Maria, George Washington University, "Prebiotics in Peritoneal Dialysis"
  • Martyniuk, Chris, University of Florida, "Metabolomics profiling in a diet-induced zebrafish model for obesity"
Resource Center for Stable Isotope-Resolved Metabolomics (RC-SIRM)
  • Wells, S, Children's Hospital Medical Center, Cincinnati, OH, "DEK reprograms metabolic networs in oral cells and epithelium"
  • Kelekar, A, Univ. of Minnesota, MN, "Metabolic adaptation in glutamine-dependent proliferating cells and cancers"
  • Rich, J., Cleveland Clinic/CWRU, OH, "Mitochondrial dynamics of brain tumor stem cells"
  • Tirouvanziam, R., Emory Univ., GA, "Metabolic reprogramming of neutrophils by the cystic fibrosis airway milieu"
  • Wright, G., East Tenessee State Univ, TN, "Isotopomer analysis of anaplerotic pathways induced by hypoxia in heart"
  • Qi, Z., Georgia Tech Univ, Atlanta GA, "Elucidating metabolic reprogramming in lung cancer cells and selenite mechanisms"
  • Ghoshal, K., Ohio State University, OH, "Testing feasibility of NMR and GC/FTMS based studies to understand the metabolic role of the liver-specific microRNA-122 in response to drug (Acetaminophen) toxicity"
  • Sudarshan, S., Univ. of Alabama Birmingham, AL, "Isoenzyme Switching and Carbohydrate Metabolism in Renal Cell Carcinoma"
  • Zhao, Y., Louisiana State Univ., Shreveport, LA, "The Role of UCP2 in Regulating Cellular Metabolism during Skin Carcinogenesis"
Metabolomics Core at Mayo Clinic
  • Liang, Mingyu, Medical College of Wisconsin, "Metabolomic Mechanisms of Dietary Salt Effects on Blood Pressure"
  • Lunt, Sophia, Michigan State University, "Role of the Serine Biosynthesis Pathway in Supporting the Warburg Effect of Pancreatic Cancer Cells"
  • Cha, Yong,-Mei, Mayo Clinic, Rochester, MN, "Left Bundle Branch Block, Myocardial Function and Metabolomics"
  • Gonsalves, Wilson, Mayo Clinic, Rochester, MN, "Identifying metabolic adatations characteristic of multiple myeloma cells via mass spectrometry-based metabolite profiling"
  • Chia, Nicholas, et al., Mayo Clinic, Rochester, MN, "Using Metabolomics to Understand How Microbial Toxicity Drives Colon Cancer"
  • Short, Kevin R., University of Oklahoma Health Sciences Center, "Biomarkers of diabetes risk in children: role of obesity and exercise."
  • Scarisbrick, Isobel A., Mayo Clinic, Rochester, MN, "Targeting Myelin Metabolism to Enhance Recovery of Function after SCI"
  • Thomas, Gail D., Penn State College of Medicine, "The dystrophic muscle metabolome: effects of exercise and NO donor therapy"

Funded P&F Projects 2014 (as of May 2014)

Michigan Regional Comprehensive Metabolomics Resource Core (MRC2)
  • Elizabeth Speliotes, University of Michigan; Metabolomic Analysis of Nonalcoholic Fatty Liver Disease
  • Jason Michael Tennessen, Indiana University; Metabolomic Analysis of Aerobic Glycolysis in Drosophila
  • Craig L. Hanis, U-Texas Health Science Center at Houston; Metabolomics, genomics, sleep apnea and aortic stiffness among Mexican Americans
  • Laura den Hartigh, University of Washington; Metabolomics analysis of adipose and liver tissue from CLA-supplemented mice
  • Jaspreet Singh, Henry Ford Health System; Metabolomics to reveal metabolite-phenotype link in X-linked Adrenoleukodystrophy
West Coast Central Comprehensive Metabolomics Resource Core (WCMC)
  • Berthier, Erwin+Keller,Nancy, U Wisconsin; Aspergillus fumigatus Oxylipins Disrupt Host Immune Eicosanoid Signaling
  • Kenyon, Nick, UC Davis; Profiling of Downstream Metabolites of L-Arginine in Severe Asthmatics
  • Sladek, Frances, UCR; Integrated Analysis of the Factors Driving Soybean Oil induced Metabolic Syndrome in Mice
  • Wedgwood, Stephen, UC Davis; Metabolomics of Neonatal Pulmonary Hypertension
  • Osborn, Olivia, UCSD; Metabolite Changes Associated with Obesity and Weight Loss
Eastern Regional Comprehensive Metabolomics Resource Core (ERCMRC)
  • Michelle Williams, Harvard University; Metabolomic Profiling of Early Pregnancy (Pre-Diagnostic Sera) from Women who Developed Placental Abruption: A Biomarker Discovery Project
  • Xuming Dai, UNC Chapel Hill School of Medicine; Metabolomics Approach to Identify Molecules and Pathways Involved in the Development of Atherosclerotic Coronary Artery Disease
  • Mitchel Kling, MD (Co-Investigator: Arnold), Perelman School of Medicine at the University of Pennsylvania; Quantitative Interrogation of One-Carbon Pathway Metabolites in CSF and Plasma of Patients with Alzheimer-Type Dementias and Comparison Subjects
  • Aimee Lander (Co-Investigator: Shelton), University of Alabama at Birmingham; Characterization and Plasticity of the Metabolome in Bipolar I Disorder
  • Patricia Sheridan (Co-Investigator: Moy), UNC-CH; Metabolomic Profiling of Anxiety Prone HSV-Latently Infected Obese Mice
  • Anthony Richardson, UNC-CH; Metabolic Adaptation of Staphylococcus aureus to Host Immunity
Southeast Center for Integrated Metabolomics (SECIM)
  • Ainsworth, Lisa, U Illinois; Metabolite Profiling of Ozone Stress in Maize
  • Kurland, Irwin; Einstein Stable Isotope and Metabolomics Core Facility; MALDI visualization and IROA profiling of lipin 1 regulation of skeletal muscle metabolism
  • Lane, Amy, U North Florida; Chemical communication signals as modulators of microbial metabolism
  • Rice, Kelly, U Florida; Utilization of a global metabolomics approach to probe the effects of nitric oxide on physiology of the pathogen Staphylococcus aureus
  • Bhattacharya, Sanjoy, U Miami; Imaging lipids in the control and glaucomatous Trabecular meshwork
  • Walsh, Thomas, Cornell U; Metabolomic-based investigation on the effects of flucononazole in Candida albicans under planktonic and biofilm conditions
  • Brooks, Samantha, U Florida and Cornell U; Metabolomic Diagnostics in the Horse
  • Cooper-DeHoff, Rhonda, U Florida; A targeted pharmacometabolomic investigation of the acylcarnitine pathway and incident impaired fasting glucose
  • Raval, Ami, U Miami; Nicotine alters brain oxidative metabolism
  • Tan, Weihong, U Florida; Aptamer-Conjugated Nanostructures for MALDI-MS Detection and Identification of Metabolites
  • McDaniel, Stuart U Florida; Portland State U; Sexual antagonism in exuded non-volatile metabolites in C. purpureus
Resource Center for Stable Isotope-Resolved Metabolomics (RC-SIRM)
  • C Dang, Abramson/Penn; Testing the role of alternative splicing in cancer metabolism
  • A Le, JHU; Applying Metabolomic Technologies to personalize cancer treatment. Pancreatic Ca/BPTES
  • J Roback, Emory; Dissecting metabolic fluxes in stored RBC units to improve transfusion outcomes
  • M Evers, UKy; Neurotensin regulation, secretion and function in health and disease-Liver lipids
  • R Wang, OSU Childrens; T cells
Metabolomics Core at Mayo Clinic
  • Johnson, Bruce, Mayo Clinic Rochester; Metabolomics of exhaled breath condensate in decompensated heart failure
  • Xu, Xiaolei, Mayo Clinic Rochester; Deciphering cardioprotective effects of mTOR inhibition via metabolite profiling
  • Frigo, Daniel, University of Houston; Metabolic dissection of aberrant glutamine metabolism in prostate cancer
  • O'Neill, Brian, Joslin Diabetes Center; Role of muscle insulin and IGF-1 signaling on serum and muscle metabolite profiles
  • Pak, Victoria, University of Pennsylvania; Targeted metabolic and biological markers of sleepiness symptoms in sleep apnea and cardiovascular disease
  • Seals, Douglas, University of Colorado; Effects of Curcumin Supplementation on the Plasma Metabolome of Older Adults: Relation to Vascular Function
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