Summary of Study ST002476
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001599. The data can be accessed directly via it's Project DOI: 10.21228/M8113P This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.
Study ID | ST002476 |
Study Title | High body temperature increases gut microbiota-dependent host resistance to influenza A virus and SARS-CoV-2 infection (Mouse) |
Study Summary | While a common symptom of influenza and coronavirus disease 2019 (COVID-19) is fever, its physiological role on host resistance to viral infection remains less clear. Here, we demonstrate that exposure of mice to the high ambient temperature of 36 °C increase host resistance to viral pathogens including influenza virus and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). High heat-exposed mice increase basal body temperature over 38 °C to enable more bile acids production in a gut microbiota-dependent manner. The gut microbiota-derived deoxycholic acid (DCA) and its plasma membrane-bound receptor Takeda G-protein-coupled receptor 5 (TGR5) signaling increase host resistance to influenza virus infection by suppressing virus replication and neutrophil-dependent tissue damage. Furthermore, the DCA and its nuclear farnesoid X receptor (FXR) agonist protect Syrian hamster from lethal SARS-CoV-2 infection. Moreover, we demonstrate that certain bile acids are reduced in the plasma of COVID-19 patients who developed moderate I/II disease compared with minor illness group. These findings uncover an unexpected mechanism by which virus-induced high fever increases host resistance to influenza virus and SARS-CoV-2 in a gut microbiota-dependent manner. |
Institute | Keio University |
Last Name | Fukuda |
First Name | Shinji |
Address | Kakuganji 246-2, Mizukami, Tsuruoka City Yamagata,Japan |
sfukuda@sfc.keio.ac.jp | |
Phone | +81-235-29-0528 |
Submit Date | 2023-01-24 |
Raw Data Available | Yes |
Raw Data File Type(s) | d |
Analysis Type Detail | CE-MS |
Release Date | 2023-03-10 |
Release Version | 2 |
Select appropriate tab below to view additional metadata details:
Combined analysis:
Analysis ID | AN004077 | AN004078 |
---|---|---|
Analysis type | MS | MS |
Chromatography type | CE | CE |
Chromatography system | Agilent CE | Agilent CE |
Column | Fused-silica, i.d. 50 µm(cation) | COSMO(+), i.d.50 μm(anion) |
MS Type | ESI | ESI |
MS instrument type | TOF | TOF |
MS instrument name | Agilent CE-TOFMS | Agilent CE-TOFMS |
Ion Mode | POSITIVE | NEGATIVE |
Units | nmol/g | nmol/g |