Summary of Study ST002481
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001603. The data can be accessed directly via it's Project DOI: 10.21228/M8H131 This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.
| Study ID | ST002481 |
| Study Title | Urolithin A (UroA) acts at CYP1A1/1B1 substrates leading to enhanced aryl hydrocarbon receptor (AHR) activity in vivo |
| Study Summary | Many AHR ligands are CYP1A1/1B1 substrates, which can result in the rapid clearance within the intestinal tract and other tissues, limiting both the level and duration of AHR activation. This leads to the hypothesis that there are dietary constituents capable of inhibiting CYP1A1/1B1 increasing the half-live of potent AHR ligands. To test this hypothesis, we examined the ability of urolithin A (UroA) to act at CYP1A1/1B1 substrates leading to enhanced AHR activity in vivo. |
| Institute | Pennsylvania State University |
| Last Name | DONG |
| First Name | FANGCONG |
| Address | 309 Life Sciences Building, State college, PA, 16802, USA |
| fxd93@psu.edu | |
| Phone | 8146990203 |
| Submit Date | 2023-02-16 |
| Raw Data Available | Yes |
| Raw Data File Type(s) | mzML |
| Analysis Type Detail | LC-MS |
| Release Date | 2023-03-02 |
| Release Version | 1 |
Select appropriate tab below to view additional metadata details:
Factors:
Subject type: Cultured cells; Subject species: Mus musculus (Factor headings shown in green)
| mb_sample_id | local_sample_id | Time (min) |
|---|---|---|
| SA248214 | 4_UroA_0_2 | 0 |
| SA248215 | 4_UroA_0_3 | 0 |
| SA248216 | 3_ICZ_0_1 | 0 |
| SA248217 | 2_luciferin CEE_0_2 | 0 |
| SA248218 | 3_ICZ_0_3 | 0 |
| SA248219 | 4_UroA_0_1 | 0 |
| SA248220 | 1_UroA_0_1 | 0 |
| SA248221 | 2_luciferin CEE_0_1 | 0 |
| SA248222 | 3_ICZ_0_2 | 0 |
| SA248223 | 2_luciferin CEE_0_3 | 0 |
| SA248224 | 1_UroA_0_3 | 0 |
| SA248225 | 1_UroA_0_2 | 0 |
| SA248226 | 1_UroA_10_3 | 10 |
| SA248227 | 1_UroA_10_2 | 10 |
| SA248228 | 1_UroA_10_1 | 10 |
| SA248253 | 5_Purified diet_2 | 120 |
| SA248254 | 5_Purified diet_3 | 120 |
| SA248255 | 5_Purified diet_1 | 120 |
| SA248256 | 5_Purified diet_UroA_2 | 120 |
| SA248257 | 5_Purified diet_UroA_3 | 120 |
| SA248258 | 5_Purified diet_UroA_1 | 120 |
| SA248259 | 3_ICZ_120_1 | 120 |
| SA248260 | 3_ICZ_UroA_120_1 | 120 |
| SA248261 | 3_ICZ_120_3 | 120 |
| SA248262 | 3_ICZ_120_2 | 120 |
| SA248263 | 3_ICZ_UroA_120_2 | 120 |
| SA248264 | 3_ICZ_UroA_120_3 | 120 |
| SA248265 | 3_ICZ_UroA_without NADPH_120_2 | 120 |
| SA248266 | 3_ICZ_UroA_without NADPH_120_1 | 120 |
| SA248267 | 3_ICZ_UroA_without NADPH_120_3 | 120 |
| SA248229 | 1_UroA_20_1 | 20 |
| SA248230 | 1_UroA_20_3 | 20 |
| SA248231 | 1_UroA_20_2 | 20 |
| SA248232 | 1_UroA_40_3 | 40 |
| SA248233 | 1_UroA_40_2 | 40 |
| SA248234 | 1_UroA_40_1 | 40 |
| SA248235 | 4_UroA_90_2 | 90 |
| SA248236 | 4_UroA_ICZ_without NADPH_90_1 | 90 |
| SA248237 | 4_UroA_ICZ_without NADPH_90_3 | 90 |
| SA248238 | 4_UroA_ICZ_90_3 | 90 |
| SA248239 | 4_UroA_ICZ_90_2 | 90 |
| SA248240 | 4_UroA_90_3 | 90 |
| SA248241 | 4_UroA_ICZ_90_1 | 90 |
| SA248242 | 4_UroA_90_1 | 90 |
| SA248243 | 2_luciferin CEE_without NADPH_90_2 | 90 |
| SA248244 | 2_luciferin CEE_ICZ_90_2 | 90 |
| SA248245 | 2_luciferin CEE_ICZ_90_3 | 90 |
| SA248246 | 2_luciferin CEE_ICZ_90_1 | 90 |
| SA248247 | 2_luciferin CEE_90_3 | 90 |
| SA248248 | 2_luciferin CEE_90_1 | 90 |
| SA248249 | 2_luciferin CEE_90_2 | 90 |
| SA248250 | 2_luciferin CEE_without NADPH_90_1 | 90 |
| SA248251 | 4_UroA_ICZ_without NADPH_90_2 | 90 |
| SA248252 | 2_luciferin CEE_without NADPH_90_3 | 90 |
| Showing results 1 to 54 of 54 |
