Summary of Study ST002588

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001020. The data can be accessed directly via it's Project DOI: 10.21228/M8V97D This work is supported by NIH grant, U2C- DK119886.

See: https://www.metabolomicsworkbench.org/about/howtocite.php

This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.

Study ID	ST002588
Study Title	MoTrPAC: Endurance exercise training study in young adult rats, Tissue:Hippocampus - Targeted Amines
Study Summary	The goal of the endurance exercise training study in young adult rats (internal code: PASS1B-06) was to perform exercise training studies in adult (6 month) F344 rats, and from these rats collect as many tissues as feasible in order to provide high quality samples for detailed analysis by chemical analysis sites. Tissues were collected from 10-12 rats sedentary control rats concurrent with the collection of the 8-week training groups. The 8-week training group and controls were from the same cohort and same age at euthanasia (either 8). For the older age group, an additional set of controls (n=5-6) were collected with the 1-2 week training group. Rats were either sedentary or underwent an exercise training program. Rats were exercised on the rodent treadmill 5 days per week using a progressive training protocol designed to exercise the rats at approximately 70% of VO2max as outlined in the Table on the next page. Training was performed no earlier than 10:00 am and no later than 5:00 pm over 5 consecutive days per week. Training was initiated with the treadmill set at 70% of VO2 max (see tables) and 5 degrees grade for 20 minutes. The duration of exercise was increased by one minute each day until day 31 of training (start of week 7), when a duration of 50 min was reached. Speed and grade of each training session increased in larger increments due to treadmill parameters. The highest intensity and duration of training began on day 31. This intensity was maintained for the final 10 days of the protocol to ensure steady state had been achieved. If any rats were unable to perform at least 4 days of training per week they were removed from the study and euthanized. It is important to note that the starting treadmill speed varied depending on the sex and age of the rat. The initial and maximum speeds were based on VO2max measurements obtained during the pre-training testing of the compliant rats. Rats assigned to the control group followed a schedule similar to the training group. They were placed in one lane on the treadmill for 15 minutes/day, 5 days per week. The treadmill was set at 0 m/min at an incline that corresponded to the incline being used by the training group.
Institute	Mayo Clinic
Department	Internal Medicine
Laboratory	Mayo Clinic Metabolomics Resource Core (MCMRC)
Last Name	Nair
First Name	K. Sreekumaran
Address	200 1st St SW, Rochester, MN 55902
Email	nair@mayo.edu
Phone	(507) 284-2511
Submit Date	2023-04-25
Raw Data Available	Yes
Raw Data File Type(s)	TBD
Analysis Type Detail	LC-MS
Release Date	2023-10-06
Release Version	1

Select appropriate tab below to view additional metadata details:

Factors:

Subject type: Mammal; Subject species: Rattus norvegicus (Factor headings shown in green)

mb_sample_id	local_sample_id	Group	Timepoint	Sex
SA259263	90245015210	Control	8 weeks of training or control time	Female
SA259264	90252015210	Control	8 weeks of training or control time	Female
SA259265	90265015210	Control	8 weeks of training or control time	Female
SA259266	90266015210	Control	8 weeks of training or control time	Female
SA259267	90248015210	Control	8 weeks of training or control time	Female
SA259268	90239015210	Control	8 weeks of training or control time	Male
SA259269	90237015210	Control	8 weeks of training or control time	Male
SA259270	90229015210	Control	8 weeks of training or control time	Male
SA259271	90217015210	Control	8 weeks of training or control time	Male
SA259272	90232015210	Control	8 weeks of training or control time	Male
SA259273	90564015210	Training	1 week of training or control time	Female
SA259274	90560015210	Training	1 week of training or control time	Female
SA259275	90559015210	Training	1 week of training or control time	Female
SA259276	90567015210	Training	1 week of training or control time	Female
SA259277	90571015210	Training	1 week of training or control time	Female
SA259278	90422015210	Training	1 week of training or control time	Male
SA259279	90421015210	Training	1 week of training or control time	Male
SA259280	90426015210	Training	1 week of training or control time	Male
SA259281	90430015210	Training	1 week of training or control time	Male
SA259282	90423015210	Training	1 week of training or control time	Male
SA259283	90581015210	Training	2 weeks of training	Female
SA259284	90578015210	Training	2 weeks of training	Female
SA259285	90576015210	Training	2 weeks of training	Female
SA259286	90450015210	Training	2 weeks of training	Male
SA259287	90441015210	Training	2 weeks of training	Male
SA259288	90444015210	Training	2 weeks of training	Male
SA259289	90449015210	Training	2 weeks of training	Male
SA259290	90439015210	Training	2 weeks of training	Male
SA259291	90416015210	Training	4 weeks of training	Female
SA259292	90410015210	Training	4 weeks of training	Female
SA259293	90412015210	Training	4 weeks of training	Female
SA259294	90420015210	Training	4 weeks of training	Female
SA259295	90289015210	Training	4 weeks of training	Male
SA259296	90280015210	Training	4 weeks of training	Male
SA259297	90292015210	Training	4 weeks of training	Male
SA259298	90281015210	Training	4 weeks of training	Male
SA259299	90283015210	Training	4 weeks of training	Male
SA259300	90254015210	Training	8 weeks of training or control time	Female
SA259301	90251015210	Training	8 weeks of training or control time	Female
SA259302	90258015210	Training	8 weeks of training or control time	Female
SA259303	90259015210	Training	8 weeks of training or control time	Female
SA259304	90267015210	Training	8 weeks of training or control time	Female
SA259305	90222015210	Training	8 weeks of training or control time	Male
SA259306	90218015210	Training	8 weeks of training or control time	Male
SA259307	90225015210	Training	8 weeks of training or control time	Male
SA259308	90227015210	Training	8 weeks of training or control time	Male
SA259309	90223015210	Training	8 weeks of training or control time	Male

Showing results 1 to 47 of 47

Showing results 1 to 47 of 47