Summary of Study ST002707

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001678. The data can be accessed directly via it's Project DOI: 10.21228/M8T146 This work is supported by NIH grant, U2C- DK119886.

See: https://www.metabolomicsworkbench.org/about/howtocite.php

This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.

Perform statistical analysis  |  Show all samples  |  Show named metabolites  |  Download named metabolite data  
Download mwTab file (text)   |  Download mwTab file(JSON)   |  Download data files (Contains raw data)
Study IDST002707
Study TitleLevels of T3 (triiodothyronine) and T4 (thyroxine) in CSF (cerebrospinal fluid) and plasma as part of natural diurnal variation
Study SummaryThis study employs targeted LC-MS analysis of CSF and plasma to assess relative changes in the levels of thyroid hormone (T3: triiodothyronine and T4: thyroxine) at two time points in the diurnal cycle. For this purpose, wild-type CD1 mice were kept in a circadian cabinet housing with 12-hour light cycle (7 a.m. on/ 7 p.m. off) and tissues were collected consistently at an a.m and a p.m time point (9 a.m. and 9 p.m). CSF was collected from adult (3 months old). Internal standards (13C-labelled T3 and T4) as well as calibration curves were used to estimate the respective T3 and T4 concentration in the examined biofluids.
Institute
Boston Children's Hospital, Harvard Medical School
LaboratoryKanarek Lab
Last NamePetrova
First NameBoryana
AddressEnders 1116.2 300 Longwood Ave
EmailBoryana.Petrova@childrens.harvard.edu
Phone6179197352
Submit Date2023-05-15
Num Groups2
Total Subjects27
Raw Data AvailableYes
Raw Data File Type(s)raw(Thermo)
Analysis Type DetailLC-MS
Release Date2023-05-28
Release Version1
Boryana Petrova Boryana Petrova
https://dx.doi.org/10.21228/M8T146
ftp://www.metabolomicsworkbench.org/Studies/ application/zip

Select appropriate tab below to view additional metadata details:

Factors:

Subject type: Mammal; Subject species: Mus musculus (Factor headings shown in green)

mb_sample_id local_sample_id Diurnal_Cycle
SA272184RF176B0.2nM T3 standard
SA272185RF1760.2nM T3 standard
SA272186RF1830.2nM T4 standard
SA272187RF183B0.2nM T4 standard
SA272188RF1750nM T3 standard
SA272189RF175B0nM T3 standard
SA272190RF1820nM T4 standard
SA272191RF182B0nM T4 standard
SA272192RF179B200nM T3 standard
SA272193RF179200nM T3 standard
SA272194RF186200nM T4 standard
SA272195RF186B200nM T4 standard
SA272196RF17820nM T3 standard
SA272197RF178B20nM T3 standard
SA272198RF185B20nM T4 standard
SA272199RF18520nM T4 standard
SA272200RF181B20uM T3 standard
SA272201RF18120uM T3 standard
SA272202RF188B20uM T4 standard
SA272203RF18820uM T4 standard
SA272204RF177B2nM T3 standard
SA272205RF1772nM T3 standard
SA272206RF1842nM T4 standard
SA272207RF184B2nM T4 standard
SA272208RF1802uM T3 standard
SA272209RF180B2uM T3 standard
SA272210RF187B2uM T4 standard
SA272211RF1872uM T4 standard
SA272212RF146AM_CSF (TopPhase)
SA272213RF204AM_CSF (TopPhase)
SA272214RF202AM_CSF (TopPhase)
SA272215RF201AM_CSF (TopPhase)
SA272216RF205AM_CSF (TopPhase)
SA272217RF203AM_CSF (TopPhase)
SA272218RF145AM_CSF (TopPhase)
SA272219RF148AM_CSF (TopPhase)
SA272220RF147AM_CSF (TopPhase)
SA272221RF150AM_CSF (TopPhase)
SA272222RF149AM_CSF (TopPhase)
SA272223RF151AM_CSF (TopPhase)
SA272224RF200AM_CSF (TopPhase)
SA272225RF219AM_Serum (TopPhase)
SA272226RF220AM_Serum (TopPhase)
SA272227RF162AM_Serum (TopPhase)
SA272228RF218AM_Serum (TopPhase)
SA272229RF165AM_Serum (TopPhase)
SA272230RF221AM_Serum (TopPhase)
SA272231RF166AM_Serum (TopPhase)
SA272232RF164AM_Serum (TopPhase)
SA272233RF216AM_Serum (TopPhase)
SA272234RF217AM_Serum (TopPhase)
SA272235RF163AM_Serum (TopPhase)
SA272236RF155PM_CSF (TopPhase)
SA272237RF154PM_CSF (TopPhase)
SA272238RF153PM_CSF (TopPhase)
SA272239RF157PM_CSF (TopPhase)
SA272240RF156PM_CSF (TopPhase)
SA272241RF158PM_CSF (TopPhase)
SA272242RF152PM_CSF (TopPhase)
SA272243RF222PM_Serum (TopPhase)
SA272244RF228PM_Serum (TopPhase)
SA272245RF227PM_Serum (TopPhase)
SA272246RF226PM_Serum (TopPhase)
SA272247RF225PM_Serum (TopPhase)
SA272248RF224PM_Serum (TopPhase)
SA272249RF223PM_Serum (TopPhase)
SA272250RF209PM_Serum (TopPhase)
SA272251RF170PM_Serum (TopPhase)
SA272252RF206PM_Serum (TopPhase)
SA272253RF207PM_Serum (TopPhase)
SA272254RF171PM_Serum (TopPhase)
SA272255RF169PM_Serum (TopPhase)
SA272256RF167PM_Serum (TopPhase)
SA272257RF168PM_Serum (TopPhase)
SA272258RF210PM_Serum (TopPhase)
SA272259RF208PM_Serum (TopPhase)
SA272260RF212PM_Serum (TopPhase)
SA272261RF211PM_Serum (TopPhase)
SA272262RF215Apool CSF RF200-212 01x_A
SA272263RF215Bpool CSF RF200-212 01x_B
SA272264RF214pool CSF RF200-212 03x
SA272265RF213Apool CSF RF200-212 1x_A
SA272266RF213Bpool CSF RF200-212 1x_B
SA272267RF213Cpool CSF RF200-212 1x_C
SA272268RF161Apool RF159-172 01x_A
SA272269RF161Bpool RF159-172 01x_B
SA272270RF161Cpool RF159-172 01x_C
SA272271RF160Apool RF159-172 03x_A
SA272272RF160Bpool RF159-172 03x_B
SA272273RF159Apool RF159-172 1x_A
SA272274RF159Bpool RF159-172 1x_B
SA272275RF159Cpool RF159-172 1x_C
SA272276RF174Apool RF176-185 01x_A
SA272277RF174Bpool RF176-185 01x_B
SA272278RF174Cpool RF176-185 01x_C
SA272279RF173Apool RF176-185 03x_A
SA272280RF173Bpool RF176-185 03x_B
SA272281RF172Apool RF176-185 1x_A
SA272282RF172Bpool RF176-185 1x_B
SA272283RF172Cpool RF176-185 1x_C
Showing page 1 of 2     Results:    1  2  Next     Showing results 1 to 100 of 106
  logo