Summary of Study ST001152
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR000771. The data can be accessed directly via it's Project DOI: 10.21228/M8197Z This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.
| Study ID | ST001152 |
| Study Title | Metabolomic Analysis of Liver Tissues for Characterization of Hepatocellular Carcinoma |
| Study Summary | Hepatocellular carcinoma (HCC) is the most common type of primary liver cancer causing more than half a million annual deaths world-wide. Understanding the molecular mechanisms contributing to HCC development and progression is highly desirable for improved surveillance, diagnosis and treatment. Liver tissue metabolomics has the potential to reflect the physiological changes behind HCC development. Also, it allows researchers to investigate racial disparities in HCC. The use of both gas chromatography – mass spectrometry (GC-MS) and liquid chromatography – mass spectrometry (LC-MS) platforms helps increase the metabolome coverage, allowing researchers to better unravel the relationships of metabolites and HCC. The objective of this study is to identify HCC-associated metabolites by analysis of liver tissues from HCC patients using both GC-MS and LC-MS platforms. Paired tumor and non-tumor tissues from 40 patients were analyzed by GC-MS and LC-MS. The patients consist of 14 African-Americans (AA), 10 Asian-Americans (AS), and 16 European-Americans (EA). The levels of the metabolites extracted from the solid liver tissue of the HCC area and adjacent non-HCC area were compared. Among the analytes detected by GC-MS and LC-MS with significant alterations, 17 were selected based on availability of putative metabolite identifications. These metabolites belong to TCA cycle, glycolysis, purines, and lipid metabolism, and have been previously reported in liver metabolomics studies where high correlation with HCC progression was implied. We demonstrated that metabolites that are related to HCC pathogenesis can be identified through metabolomics analysis of liver tissues by both GC-MS and LC-MS. In addition, this analysis has led to the identification of metabolites associated with HCC in a race-specific manner. |
| Institute | Georgetown University |
| Department | Oncology |
| Laboratory | Ressom Lab |
| Last Name | Di Poto |
| First Name | Cristina |
| Address | 3970 Reservoir Rd. NW, Research Bldg., Room W325 |
| cd329@georgetown.edu | |
| Phone | 2026872926 |
| Submit Date | 2019-03-07 |
| Num Groups | 4 |
| Total Subjects | 40 |
| Raw Data Available | Yes |
| Raw Data File Type(s) | cdf, raw(Waters) |
| Analysis Type Detail | GC-MS/LC-MS |
| Release Date | 2020-03-03 |
| Release Version | 1 |
Select appropriate tab below to view additional metadata details:
Factors:
Subject type: Human; Subject species: Homo sapiens (Factor headings shown in green)
| mb_sample_id | local_sample_id | Group |
|---|---|---|
| SA079912 | HCC/CIRR 07_ADJ/C | ADJ/C | RACE:Black |
| SA079913 | HCC/CIRR 08_ADJ/C | ADJ/C | RACE:Black |
| SA079914 | HCC/CIRR 02_ADJ/C | ADJ/C | RACE:Black |
| SA079915 | HCC/CIRR 01_ADJ/C | ADJ/C | RACE:Black |
| SA079916 | HCC/CIRR 06_ADJ/C | ADJ/C | RACE:Black |
| SA079917 | HCC/CIRR 09_ADJ/C | ADJ/C | RACE:White |
| SA079918 | HCC/CIRR 10_ADJ/C | ADJ/C | RACE:White |
| SA079919 | HCC/CIRR 05_ADJ/C | ADJ/C | RACE:White |
| SA079920 | HCC/CIRR 03_ADJ/C | ADJ/C | RACE:White |
| SA079921 | HCC/CIRR 04_ADJ/C | ADJ/C | RACE:White |
| SA079922 | HCC/NOR 24_ADJ/N | ADJ/N | RACE:Asian |
| SA079923 | HCC/NOR 23_ADJ/N | ADJ/N | RACE:Asian |
| SA079924 | HCC/NOR 30_ADJ/N | ADJ/N | RACE:Asian |
| SA079925 | HCC/NOR 29_ADJ/N | ADJ/N | RACE:Asian |
| SA079926 | HCC/NOR 25_ADJ/N | ADJ/N | RACE:Asian |
| SA079927 | HCC/NOR 27_ADJ/N | ADJ/N | RACE:Asian |
| SA079928 | HCC/NOR 28_ADJ/N | ADJ/N | RACE:Asian |
| SA079929 | HCC/NOR 26_ADJ/N | ADJ/N | RACE:Asian |
| SA079930 | HCC/NOR 17_ADJ/N | ADJ/N | RACE:Asian |
| SA079931 | HCC/NOR 22_ADJ/N | ADJ/N | RACE:Asian |
| SA079932 | HCC/NOR 07_ADJ/N | ADJ/N | RACE:Black |
| SA079933 | HCC/NOR 12_ADJ/N | ADJ/N | RACE:Black |
| SA079934 | HCC/NOR 08_ADJ/N | ADJ/N | RACE:Black |
| SA079935 | HCC/NOR 10_ADJ/N | ADJ/N | RACE:Black |
| SA079936 | HCC/NOR 04_ADJ/N | ADJ/N | RACE:Black |
| SA079937 | HCC/NOR 16_ADJ/N | ADJ/N | RACE:Black |
| SA079938 | HCC/NOR 03_ADJ/N | ADJ/N | RACE:Black |
| SA079939 | HCC/NOR 21_ADJ/N | ADJ/N | RACE:Black |
| SA079940 | HCC/NOR 19_ADJ/N | ADJ/N | RACE:Black |
| SA079941 | HCC/NOR 20_ADJ/N | ADJ/N | RACE:White |
| SA079942 | HCC/NOR 01_ADJ/N | ADJ/N | RACE:White |
| SA079943 | HCC/NOR 13_ADJ/N | ADJ/N | RACE:White |
| SA079944 | HCC/NOR 09_ADJ/N | ADJ/N | RACE:White |
| SA079945 | HCC/NOR 15_ADJ/N | ADJ/N | RACE:White |
| SA079946 | HCC/NOR 14_ADJ/N | ADJ/N | RACE:White |
| SA079947 | HCC/NOR 18_ADJ/N | ADJ/N | RACE:White |
| SA079948 | HCC/NOR 11_ADJ/N | ADJ/N | RACE:White |
| SA079949 | HCC/NOR 06_ADJ/N | ADJ/N | RACE:White |
| SA079950 | HCC/NOR 05_ADJ/N | ADJ/N | RACE:White |
| SA079951 | HCC/NOR 02_ADJ/N | ADJ/N | RACE:White |
| SA079952 | Blank_B | Blank | RACE:- |
| SA079953 | Blank_A | Blank | RACE:- |
| SA079954 | Blank_C | Blank | RACE:- |
| SA079955 | Blank_D | Blank | RACE:- |
| SA079956 | Blank_E | Blank | RACE:- |
| SA079957 | HCC/CIRR 02_HCC/C | HCC/C | RACE:Black |
| SA079958 | HCC/CIRR 08_HCC/C | HCC/C | RACE:Black |
| SA079959 | HCC/CIRR 07_HCC/C | HCC/C | RACE:Black |
| SA079960 | HCC/CIRR 01_HCC/C | HCC/C | RACE:Black |
| SA079961 | HCC/CIRR 06_HCC/C | HCC/C | RACE:Black |
| SA079962 | HCC/CIRR 10_HCC/C | HCC/C | RACE:White |
| SA079963 | HCC/CIRR 09_HCC/C | HCC/C | RACE:White |
| SA079964 | HCC/CIRR 05_HCC/C | HCC/C | RACE:White |
| SA079965 | HCC/CIRR 04_HCC/C | HCC/C | RACE:White |
| SA079966 | HCC/CIRR 03_HCC/C | HCC/C | RACE:White |
| SA079967 | HCC/NOR 23_HCC/N | HCC/N | RACE:Asian |
| SA079968 | HCC/NOR 30_HCC/N | HCC/N | RACE:Asian |
| SA079969 | HCC/NOR 29_HCC/N | HCC/N | RACE:Asian |
| SA079970 | HCC/NOR 24_HCC/N | HCC/N | RACE:Asian |
| SA079971 | HCC/NOR 27_HCC/N | HCC/N | RACE:Asian |
| SA079972 | HCC/NOR 26_HCC/N | HCC/N | RACE:Asian |
| SA079973 | HCC/NOR 25_HCC/N | HCC/N | RACE:Asian |
| SA079974 | HCC/NOR 28_HCC/N | HCC/N | RACE:Asian |
| SA079975 | HCC/NOR 22_HCC/N | HCC/N | RACE:Asian |
| SA079976 | HCC/NOR 17_HCC/N | HCC/N | RACE:Asian |
| SA079977 | HCC/NOR 07_HCC/N | HCC/N | RACE:Black |
| SA079978 | HCC/NOR 12_HCC/N | HCC/N | RACE:Black |
| SA079979 | HCC/NOR 08_HCC/N | HCC/N | RACE:Black |
| SA079980 | HCC/NOR 10_HCC/N | HCC/N | RACE:Black |
| SA079981 | HCC/NOR 04_HCC/N | HCC/N | RACE:Black |
| SA079982 | HCC/NOR 16_HCC/N | HCC/N | RACE:Black |
| SA079983 | HCC/NOR 03_HCC/N | HCC/N | RACE:Black |
| SA079984 | HCC/NOR 21_HCC/N | HCC/N | RACE:Black |
| SA079985 | HCC/NOR 19_HCC/N | HCC/N | RACE:Black |
| SA079986 | HCC/NOR 02_HCC/N | HCC/N | RACE:White |
| SA079987 | HCC/NOR 09_HCC/N | HCC/N | RACE:White |
| SA079988 | HCC/NOR 05_HCC/N | HCC/N | RACE:White |
| SA079989 | HCC/NOR 06_HCC/N | HCC/N | RACE:White |
| SA079990 | HCC/NOR 01_HCC/N | HCC/N | RACE:White |
| SA079991 | HCC/NOR 18_HCC/N | HCC/N | RACE:White |
| SA079992 | HCC/NOR 11_HCC/N | HCC/N | RACE:White |
| SA079993 | HCC/NOR 15_HCC/N | HCC/N | RACE:White |
| SA079994 | HCC/NOR 14_HCC/N | HCC/N | RACE:White |
| SA079995 | HCC/NOR 13_HCC/N | HCC/N | RACE:White |
| SA079996 | HCC/NOR 20_HCC/N | HCC/N | RACE:White |
| SA079997 | QC_ADJ/C_4 | QC_ADJ/C | RACE:- |
| SA079998 | QC_ADJ/C_3 | QC_ADJ/C | RACE:- |
| SA079999 | QC_ADJ/C_1 | QC_ADJ/C | RACE:- |
| SA080000 | QC_ADJ/C_5 | QC_ADJ/C | RACE:- |
| SA080001 | QC_ADJ/C_2 | QC_ADJ/C | RACE:- |
| SA080002 | QC_ADJ/C_6 | QC_ADJ/C | RACE:- |
| SA080003 | QC_ADJ/N_7 | QC_ADJ/N | RACE:- |
| SA080004 | QC_ADJ/N_8 | QC_ADJ/N | RACE:- |
| SA080005 | QC_ADJ/N_6 | QC_ADJ/N | RACE:- |
| SA080006 | QC_ADJ/N_4 | QC_ADJ/N | RACE:- |
| SA080007 | QC_ADJ/N_3 | QC_ADJ/N | RACE:- |
| SA080008 | QC_ADJ/N_5 | QC_ADJ/N | RACE:- |
| SA080009 | QC_ADJ/N_9 | QC_ADJ/N | RACE:- |
| SA080010 | QC_ADJ/N_1 | QC_ADJ/N | RACE:- |
| SA080011 | QC_ADJ/N_15 | QC_ADJ/N | RACE:- |
