Summary of Study ST001635

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001044. The data can be accessed directly via it's Project DOI: 10.21228/M8RD7H This work is supported by NIH grant, U2C- DK119886.

See: https://www.metabolomicsworkbench.org/about/howtocite.php

This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.

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Study IDST001635
Study TitleHigher Dietary Carbohydrates Detrimentally Impact Obesity-Associated Breast Cancer Chemoresistance
Study TypeUntargeted UPLC-MS Metabolomics Analysis
Study SummaryThis study is a part of an ongoing project entitled, “Higher Dietary Carbohydrates Detrimentally Impact Obesity-Associated Breast Cancer Chemoresistance.” (See project). Untargeted LCMS metabolomics analysis was performed to identify metabolic markers of nutritionally dependent and obesity-associated chemoresistance in female C57LB/6 mice fed either a high carbohydrate plus high fat (HCHF) diet or a high protein diet (HP). Mice were fed 15 weeks on either diet, then injected with a MMTV-Wnt-1 mouse mammary basal-like breast cancer cell line, for tumor formation up to 6 weeks. Three mice on either diet were treated for 24 hr with Doxorubicin or Saline as a vehicle control. All samples were analyzed in the positive mode for untargeted metabolomics analysis. Liver samples were selected for analysis because of an observation of fatty liver development in mice only on the HCHF diet after 15 weeks. Samples were extracted and analyzed by UPLS-MS analysis using Q-Exactive HFX mass spectrometer.
Institute
University of North Carolina at Chapel Hill
DepartmentNutrition
LaboratoryMetabolomics and Exposome Laboratory, Nutrition Research Institute, UNC Chapel Hill
Last NameSumner
First NameSusan
Address500 Laureate Way, Nutrition Research Institute, UNC Chapel Hill
Emailsusan_sumner@unc.edu
Phone(919) 622-4456
Submit Date2020-12-18
Num Groups6
Total Subjects193
Num Females175
Study CommentsThe number of groups includes the QC samples
Raw Data AvailableYes
Raw Data File Type(s)raw(Thermo)
Analysis Type DetailLC-MS
Release Date2021-12-18
Release Version1
Susan Sumner Susan Sumner
https://dx.doi.org/10.21228/M8RD7H
ftp://www.metabolomicsworkbench.org/Studies/ application/zip

Select appropriate tab below to view additional metadata details:

Factors:

Subject type: Mammal; Subject species: Mus musculus (Factor headings shown in green)

mb_sample_id local_sample_id Diet
SA138239L_26HCHF | Study Phenotype:15 wk Differential Diet | Treatment:None | Liver Lobe:Left
SA138240L_29HCHF | Study Phenotype:15 wk Differential Diet | Treatment:None | Liver Lobe:Left
SA138241L_41HCHF | Study Phenotype:15 wk Differential Diet | Treatment:None | Liver Lobe:Left
SA138242L_32HCHF | Study Phenotype:15 wk Differential Diet | Treatment:None | Liver Lobe:Left
SA138243L_35HCHF | Study Phenotype:15 wk Differential Diet | Treatment:None | Liver Lobe:Left
SA138244L_44HCHF | Study Phenotype:15 wk Differential Diet | Treatment:None | Liver Lobe:Left
SA138245L_38HCHF | Study Phenotype:15 wk Differential Diet | Treatment:None | Liver Lobe:Left
SA138246L_47HCHF | Study Phenotype:15 wk Differential Diet | Treatment:None | Liver Lobe:Left
SA138247L_27HCHF | Study Phenotype:15 wk Differential Diet | Treatment:None | Liver Lobe:Median
SA138248L_36HCHF | Study Phenotype:15 wk Differential Diet | Treatment:None | Liver Lobe:Median
SA138249L_39HCHF | Study Phenotype:15 wk Differential Diet | Treatment:None | Liver Lobe:Median
SA138250L_33HCHF | Study Phenotype:15 wk Differential Diet | Treatment:None | Liver Lobe:Median
SA138251L_48HCHF | Study Phenotype:15 wk Differential Diet | Treatment:None | Liver Lobe:Median
SA138252L_42HCHF | Study Phenotype:15 wk Differential Diet | Treatment:None | Liver Lobe:Median
SA138253L_45HCHF | Study Phenotype:15 wk Differential Diet | Treatment:None | Liver Lobe:Median
SA138254L_30HCHF | Study Phenotype:15 wk Differential Diet | Treatment:None | Liver Lobe:Median
SA138255L_43HCHF | Study Phenotype:15 wk Differential Diet | Treatment:None | Liver Lobe:Right
SA138256L_40HCHF | Study Phenotype:15 wk Differential Diet | Treatment:None | Liver Lobe:Right
SA138257L_46HCHF | Study Phenotype:15 wk Differential Diet | Treatment:None | Liver Lobe:Right
SA138258L_25HCHF | Study Phenotype:15 wk Differential Diet | Treatment:None | Liver Lobe:Right
SA138259L_28HCHF | Study Phenotype:15 wk Differential Diet | Treatment:None | Liver Lobe:Right
SA138260L_37HCHF | Study Phenotype:15 wk Differential Diet | Treatment:None | Liver Lobe:Right
SA138261L_31HCHF | Study Phenotype:15 wk Differential Diet | Treatment:None | Liver Lobe:Right
SA138262L_34HCHF | Study Phenotype:15 wk Differential Diet | Treatment:None | Liver Lobe:Right
SA138263L_146HCHF | Study Phenotype:24 hr Treatment | Treatment:DOX-treated | Liver Lobe:Left
SA138264L_152HCHF | Study Phenotype:24 hr Treatment | Treatment:DOX-treated | Liver Lobe:Left
SA138265L_149HCHF | Study Phenotype:24 hr Treatment | Treatment:DOX-treated | Liver Lobe:Left
SA138266L_150HCHF | Study Phenotype:24 hr Treatment | Treatment:DOX-treated | Liver Lobe:Median
SA138267L_153HCHF | Study Phenotype:24 hr Treatment | Treatment:DOX-treated | Liver Lobe:Median
SA138268L_147HCHF | Study Phenotype:24 hr Treatment | Treatment:DOX-treated | Liver Lobe:Median
SA138269L_145HCHF | Study Phenotype:24 hr Treatment | Treatment:DOX-treated | Liver Lobe:Right
SA138270L_151HCHF | Study Phenotype:24 hr Treatment | Treatment:DOX-treated | Liver Lobe:Right
SA138271L_148HCHF | Study Phenotype:24 hr Treatment | Treatment:DOX-treated | Liver Lobe:Right
SA138272L_158HCHF | Study Phenotype:24 hr Treatment | Treatment:Saline-control | Liver Lobe:Left
SA138273L_161HCHF | Study Phenotype:24 hr Treatment | Treatment:Saline-control | Liver Lobe:Left
SA138274L_155HCHF | Study Phenotype:24 hr Treatment | Treatment:Saline-control | Liver Lobe:Left
SA138275L_156HCHF | Study Phenotype:24 hr Treatment | Treatment:Saline-control | Liver Lobe:Median
SA138276L_159HCHF | Study Phenotype:24 hr Treatment | Treatment:Saline-control | Liver Lobe:Median
SA138277L_162HCHF | Study Phenotype:24 hr Treatment | Treatment:Saline-control | Liver Lobe:Median
SA138278L_157HCHF | Study Phenotype:24 hr Treatment | Treatment:Saline-control | Liver Lobe:Right
SA138279L_154HCHF | Study Phenotype:24 hr Treatment | Treatment:Saline-control | Liver Lobe:Right
SA138280L_160HCHF | Study Phenotype:24 hr Treatment | Treatment:Saline-control | Liver Lobe:Right
SA138287L_104HCHF | Study Phenotype:Tumor Growth-5.5 wk | Treatment:None | Liver Lobe:Left
SA138288L_89HCHF | Study Phenotype:Tumor Growth-5.5 wk | Treatment:None | Liver Lobe:Left
SA138289L_98HCHF | Study Phenotype:Tumor Growth-5.5 wk | Treatment:None | Liver Lobe:Left
SA138290L_86HCHF | Study Phenotype:Tumor Growth-5.5 wk | Treatment:None | Liver Lobe:Left
SA138291L_95HCHF | Study Phenotype:Tumor Growth-5.5 wk | Treatment:None | Liver Lobe:Left
SA138292L_101HCHF | Study Phenotype:Tumor Growth-5.5 wk | Treatment:None | Liver Lobe:Left
SA138293L_113HCHF | Study Phenotype:Tumor Growth-5.5 wk | Treatment:None | Liver Lobe:Left
SA138294L_110HCHF | Study Phenotype:Tumor Growth-5.5 wk | Treatment:None | Liver Lobe:Left
SA138295L_107HCHF | Study Phenotype:Tumor Growth-5.5 wk | Treatment:None | Liver Lobe:Left
SA138296L_92HCHF | Study Phenotype:Tumor Growth-5.5 wk | Treatment:None | Liver Lobe:Left
SA138297L_87HCHF | Study Phenotype:Tumor Growth-5.5 wk | Treatment:None | Liver Lobe:Median
SA138298L_96HCHF | Study Phenotype:Tumor Growth-5.5 wk | Treatment:None | Liver Lobe:Median
SA138299L_99HCHF | Study Phenotype:Tumor Growth-5.5 wk | Treatment:None | Liver Lobe:Median
SA138300L_114HCHF | Study Phenotype:Tumor Growth-5.5 wk | Treatment:None | Liver Lobe:Median
SA138301L_111HCHF | Study Phenotype:Tumor Growth-5.5 wk | Treatment:None | Liver Lobe:Median
SA138302L_108HCHF | Study Phenotype:Tumor Growth-5.5 wk | Treatment:None | Liver Lobe:Median
SA138303L_90HCHF | Study Phenotype:Tumor Growth-5.5 wk | Treatment:None | Liver Lobe:Median
SA138304L_105HCHF | Study Phenotype:Tumor Growth-5.5 wk | Treatment:None | Liver Lobe:Median
SA138305L_93HCHF | Study Phenotype:Tumor Growth-5.5 wk | Treatment:None | Liver Lobe:Median
SA138306L_94HCHF | Study Phenotype:Tumor Growth-5.5 wk | Treatment:None | Liver Lobe:Right
SA138307L_112HCHF | Study Phenotype:Tumor Growth-5.5 wk | Treatment:None | Liver Lobe:Right
SA138308L_109HCHF | Study Phenotype:Tumor Growth-5.5 wk | Treatment:None | Liver Lobe:Right
SA138309L_106HCHF | Study Phenotype:Tumor Growth-5.5 wk | Treatment:None | Liver Lobe:Right
SA138310L_103HCHF | Study Phenotype:Tumor Growth-5.5 wk | Treatment:None | Liver Lobe:Right
SA138311L_100HCHF | Study Phenotype:Tumor Growth-5.5 wk | Treatment:None | Liver Lobe:Right
SA138312L_97HCHF | Study Phenotype:Tumor Growth-5.5 wk | Treatment:None | Liver Lobe:Right
SA138313L_91HCHF | Study Phenotype:Tumor Growth-5.5 wk | Treatment:None | Liver Lobe:Right
SA138314L_85HCHF | Study Phenotype:Tumor Growth-5.5 wk | Treatment:None | Liver Lobe:Right
SA138315L_88HCHF | Study Phenotype:Tumor Growth-5.5 wk | Treatment:None | Liver Lobe:Right
SA138281L_77HCHF | Study Phenotype:Tumor Growth-5 wk | Treatment:None | Liver Lobe:Left
SA138282L_74HCHF | Study Phenotype:Tumor Growth-5 wk | Treatment:None | Liver Lobe:Left
SA138283L_78HCHF | Study Phenotype:Tumor Growth-5 wk | Treatment:None | Liver Lobe:Median
SA138284L_75HCHF | Study Phenotype:Tumor Growth-5 wk | Treatment:None | Liver Lobe:Median
SA138285L_76HCHF | Study Phenotype:Tumor Growth-5 wk | Treatment:None | Liver Lobe:Right
SA138286L_73HCHF | Study Phenotype:Tumor Growth-5 wk | Treatment:None | Liver Lobe:Right
SA138316L_56HP | Study Phenotype:15 wk Differential Diet | Treatment:None | Liver Lobe:Left
SA138317L_68HP | Study Phenotype:15 wk Differential Diet | Treatment:None | Liver Lobe:Left
SA138318L_59HP | Study Phenotype:15 wk Differential Diet | Treatment:None | Liver Lobe:Left
SA138319L_62HP | Study Phenotype:15 wk Differential Diet | Treatment:None | Liver Lobe:Left
SA138320L_65HP | Study Phenotype:15 wk Differential Diet | Treatment:None | Liver Lobe:Left
SA138321L_71HP | Study Phenotype:15 wk Differential Diet | Treatment:None | Liver Lobe:Left
SA138322L_53HP | Study Phenotype:15 wk Differential Diet | Treatment:None | Liver Lobe:Left
SA138323L_50HP | Study Phenotype:15 wk Differential Diet | Treatment:None | Liver Lobe:Left
SA138324L_51HP | Study Phenotype:15 wk Differential Diet | Treatment:None | Liver Lobe:Median
SA138325L_63HP | Study Phenotype:15 wk Differential Diet | Treatment:None | Liver Lobe:Median
SA138326L_60HP | Study Phenotype:15 wk Differential Diet | Treatment:None | Liver Lobe:Median
SA138327L_66HP | Study Phenotype:15 wk Differential Diet | Treatment:None | Liver Lobe:Median
SA138328L_57HP | Study Phenotype:15 wk Differential Diet | Treatment:None | Liver Lobe:Median
SA138329L_72HP | Study Phenotype:15 wk Differential Diet | Treatment:None | Liver Lobe:Median
SA138330L_69HP | Study Phenotype:15 wk Differential Diet | Treatment:None | Liver Lobe:Median
SA138331L_54HP | Study Phenotype:15 wk Differential Diet | Treatment:None | Liver Lobe:Median
SA138332L_61HP | Study Phenotype:15 wk Differential Diet | Treatment:None | Liver Lobe:Right
SA138333L_52HP | Study Phenotype:15 wk Differential Diet | Treatment:None | Liver Lobe:Right
SA138334L_49HP | Study Phenotype:15 wk Differential Diet | Treatment:None | Liver Lobe:Right
SA138335L_55HP | Study Phenotype:15 wk Differential Diet | Treatment:None | Liver Lobe:Right
SA138336L_58HP | Study Phenotype:15 wk Differential Diet | Treatment:None | Liver Lobe:Right
SA138337L_67HP | Study Phenotype:15 wk Differential Diet | Treatment:None | Liver Lobe:Right
SA138338L_70HP | Study Phenotype:15 wk Differential Diet | Treatment:None | Liver Lobe:Right
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