Summary of Study ST001793

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001137. The data can be accessed directly via it's Project DOI: 10.21228/M8R102 This work is supported by NIH grant, U2C- DK119886.

See: https://www.metabolomicsworkbench.org/about/howtocite.php

This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.

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Study IDST001793
Study TitleEffect of external low-dose rate radiation on mouse biofluid metabolomic signatures (part IV)
Study SummaryAn important component of ionizing radiation (IR) exposure after a radiological incident may include low-dose rate (LDR) exposures either externally or internally, such as from 137Cs deposition. LDR exposures can have different effects compared to acute high-dose rate exposures from a health and biodosimetry perspective. In this study, a novel irradiation system, VAriable Dose-rate External 137Cs irradiatoR (VADER), was used to expose male and female mice to a variable LDR over a 30-day time span to cumulative doses of 1 (only in males), 2, 2.8, 4.1, 8.8 (only in males), or 9.7 Gy to simulate fall-out type exposures. Urine and serum from mice exposed to an acute dose (~0.8 Gy/min) of x-rays were collected in parallel. Radiation markers were identified by global mass spectrometry based metabolomics and the machine learning algorithm Random Forests.
Institute
Georgetown University
Last NamePannkuk
First NameEvan
Address3970 Reservoir Rd, NW New Research Building E504
Emailelp44@georgetown.edu
Phone2026875650
Submit Date2021-05-12
Raw Data AvailableYes
Raw Data File Type(s)raw(Waters)
Analysis Type DetailLC-MS
Release Date2021-12-15
Release Version1
Evan Pannkuk Evan Pannkuk
https://dx.doi.org/10.21228/M8R102
ftp://www.metabolomicsworkbench.org/Studies/ application/zip

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Factors:

Subject type: Mammal; Subject species: Mus musculus (Factor headings shown in green)

mb_sample_id local_sample_id Factor Factor
SA16703868D2 Control
SA16703912D2 Control
SA16704014D2 Control
SA16704116D2 Control
SA16704280D2 Control
SA1670438D2 Control
SA16704438D2 Control
SA16704548D2 Control
SA1670461D2 Control
SA16704742D2 Control
SA16704856D2 Control
SA16704939D2 Control
SA16705026D2 HDR
SA16705161D2 HDR
SA16705227D2 HDR
SA16705379D2 HDR
SA16705462D2 HDR
SA16705522D2 HDR
SA16705618D2 HDR
SA16705781D2 HDR
SA16705883D2 HDR
SA16705910D2 LDR
SA16706036D2 LDR
SA16706111D2 LDR
SA16706270D2 LDR
SA16706358D30 Control
SA16706447D30 Control
SA16706549D30 Control
SA16706643D30 Control
SA16706733D30 Control
SA16706873D30 Control
SA16706913D30 Control
SA16707015D30 LDR
SA16707188D30 LDR
SA1670722D30 LDR
SA16707386D30 LDR
SA16707475D30 LDR
SA16707530D30 LDR
SA16707620D30 LDR
SA16707772D3 Control
SA16707863D3 Control
SA16707969D3 Control
SA16708084D3 Control
SA16708145D3 Control
SA16708229D3 Control
SA16708323D3 Control
SA1670845D3 Control
SA1670853D3 Control
SA16708635D3 Control
SA16708728D3 Control
SA16708821D3 HDR
SA16708978D3 HDR
SA1670909D3 HDR
SA1670914D3 HDR
SA16709251D3 HDR
SA16709324D3 HDR
SA16709454D3 HDR
SA16709553D3 LDR
SA16709655D3 LDR
SA16709782D3 LDR
SA16709846D3 LDR
SA16709971D3 LDR
SA16710041D3 LDR
SA16710176D5 Control
SA16710260D5 Control
SA16710377D5 Control
SA16710440D5 Control
SA1671056D5 Control
SA16710666D5 Control
SA16710731D5 Control
SA16710887D5 Control
SA16710959D5 Control
SA16711067D5 Control
SA16711125D5 Control
SA16711252D5 Control
SA16711364D5 Control
SA16711444D5 Control
SA16711585D5 HDR
SA1671167D5 HDR
SA16711750D5 HDR
SA16711865D5 HDR
SA16711974D5 HDR
SA16712089D5 LDR
SA16712137D5 LDR
SA16712232D5 LDR
SA16712319D5 LDR
SA16712417D5 LDR
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