Summary of Study ST002209

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001410. The data can be accessed directly via it's Project DOI: 10.21228/M8G42C This work is supported by NIH grant, U2C- DK119886.

See: https://www.metabolomicsworkbench.org/about/howtocite.php

This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.

Show all samples  
Download mwTab file (text)   |  Download mwTab file(JSON)   |  Download data files (Contains raw data)
Study IDST002209
Study TitleMetabolomic analysis to assess response to immunotherapy for malignant brain tumors: Part 3
Study TypeCancer surrogate biomarker discovery
Study SummaryAn effective immune response in patients with cancer treated with immunotherapy includes dendritic cell (DC) activation and migration followed by stimulation of CD8 and CD4 T cells. This then leads to the activation, proliferation and further activation of other immune cell populations including NK cells or immunosuppressive populations such as Tregs and myeloid derived suppressor cells (MDSCs). These studies were carried out utilizing murine brain tumor models treated with an RNA DC vaccine platform. We hypothesized that metabolomic analyses of urines would be sensitive to the action of this diverse set of immune cells. The objective of this study was to evaluate the feasibility of using metabolomics to follow immune responses after immunotherapy. We chose NMR as our analytical technique of choice, as it has many favorable qualities that make it ideal for analyses of urine.
Institute
University of Florida
DepartmentApplied Physiology and Kinesiology
LaboratoryRm 042
Last NameKhattri
First NameRam
Address1200 Newell Dr., ARB 240, Gainesville, FL, 32611, USA
Emailrbk11@ufl.edu
Phone3307856045
Submit Date2022-06-09
Num Groups5
Total Subjects24
Num MalesNA
Num FemalesNA
Study CommentsMetabolomic profiling of urine samples
PublicationsMetabolomics journal (submitted)
Raw Data AvailableYes
Raw Data File Type(s)fid
Analysis Type DetailNMR
Release Date2023-06-16
Release Version1
Ram Khattri Ram Khattri
https://dx.doi.org/10.21228/M8G42C
ftp://www.metabolomicsworkbench.org/Studies/ application/zip

Select appropriate tab below to view additional metadata details:

Factors:

Subject type: Mammal; Subject species: Mus musculus (Factor headings shown in green)

mb_sample_id local_sample_id Group
SA211487Maryam_serum_Control-1Control
SA211488Maryam_serum_Control-5Control
SA211489Maryam_serum_Control-4Control
SA211490Maryam_serum_Control-2Control
SA211491Maryam_serum_Control-3Control
SA211492Maryam_serum_PostV_24hrs-5PostV_24hrs
SA211493Maryam_serum_PostV_24hrs-4PostV_24hrs
SA211494Maryam_serum_PostV_24hrs-1PostV_24hrs
SA211495Maryam_serum_PostV_24hrs-3PostV_24hrs
SA211496Maryam_serum_PostV_24hrs-2PostV_24hrs
SA211497Maryam_serum_PostV_48hrs-4PostV_48hrs
SA211498Maryam_serum_PostV_48hrs-5PostV_48hrs
SA211499Maryam_serum_PostV_48hrs-1PostV_48hrs
SA211500Maryam_serum_PostV_48hrs-3PostV_48hrs
SA211501Maryam_serum_PostV_48hrs-2PostV_48hrs
SA211502Maryam_serum_PostV_7days-5PostV_7 days
SA211503Maryam_serum_PostV_7days-4PostV_7 days
SA211504Maryam_serum_PostV_7days-3PostV_7 days
SA211505Maryam_serum_PostV_7days-1PostV_7 days
SA211506Maryam_serum_PostV_7days-2PostV_7 days
SA211507Maryam_serum_PostV_Day0-4PostV_Day0
SA211508Maryam_serum_PostV_Day0-2PostV_Day0
SA211509Maryam_serum_PostV_Day0-3PostV_Day0
SA211510Maryam_serum_PostV_Day0-1PostV_Day0
SA211511Maryam_serum_PreV_Day0-4PreV_Day0
SA211512Maryam_serum_PreV_Day0-5PreV_Day0
SA211513Maryam_serum_PreV_Day0-3PreV_Day0
SA211514Maryam_serum_PreV_Day0-1PreV_Day0
SA211515Maryam_serum_PreV_Day0-2PreV_Day0
Showing results 1 to 29 of 29
  logo