Summary of Study ST002449

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001064. The data can be accessed directly via it's Project DOI: 10.21228/M85H6W This work is supported by NIH grant, U2C- DK119886.

See: https://www.metabolomicsworkbench.org/about/howtocite.php

This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.

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Study IDST002449
Study TitleIdentify putative volatile biomarkers of Valley fever using a murine lung infection model (Human studies)
Study TypeUntargeted metabolomics
Study SummaryCoccidioides immitis and Coccidioides posadasii are soil-dwelling fungi of arid regions in North and South America that are responsible for Valley fever (coccidioidomycosis). Forty percent of patients with Valley fever exhibit symptoms ranging from mild, self-limiting respiratory infections, to severe, life-threatening pneumonia that requires treatment. Misdiagnosis as bacterial pneumonia commonly occurs in symptomatic Valley fever cases, resulting in inappropriate treatment with antibiotics, increased medical costs, and delay in diagnosis. In this study, we explored the feasibility of developing breath-based diagnostics for Valley fever using lung specimens from persons with community-acquired pneumonia (CAP). To investigate potential volatile biomarkers of Valley fever that arise from host-pathogen interactions, we collected bronchoalveolar lavage fluid (BALF) and sputum from patients treated at Mayo Clinic in Scottsdale, Arizona for untargeted volatile metabolomics via solid phase microextraction (SPME) and two-dimensional gas chromatography coupled to time-of-flight mass spectrometry (GC×GC-TOFMS). We identified 244 total volatile organic compounds (VOCs). Using Random Forest, we identified a subset of these VOCs that were also able to separate Coccidioides positive samples from bacteria positive samples. The data presented here show that Coccidioides and/or the host produce volatile metabolites that may yield biomarkers for a Valley fever breath test that can detect Coccidioidal infection.
Institute
Arizona State University
DepartmentSchool of Life Sciences
LaboratoryBean Laboratory
Last NameBean
First NameHeather
AddressPO Box 874501
EmailHeather.D.Bean@asu.edu
Phone4807273395
Submit Date2022-12-17
Raw Data AvailableYes
Raw Data File Type(s)smp
Analysis Type DetailGC-MS
Release Date2024-01-31
Release Version1
Heather Bean Heather Bean
https://dx.doi.org/10.21228/M85H6W
ftp://www.metabolomicsworkbench.org/Studies/ application/zip

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Factors:

Subject type: Mammal; Subject species: Homo sapiens (Factor headings shown in green)

mb_sample_id local_sample_id Subject treatment
SA244821Standard_mix_3Alkane Standard and Grob Mix Standard Mix
SA244822Standard_mix_2Alkane Standard and Grob Mix Standard Mix
SA244823Standard_1Alkane Standard and Grob Mix Standard Mix
SA244824Standard mix_1Alkane Standard and Grob Mix Standard Mix
SA244825Standard_mix_1Alkane Standard and Grob Mix Standard Mix
SA244826Blank_2Empty run NA
SA244827Blank_7Empty run NA
SA244828Blank_1Empty run NA
SA244829Blank_3Empty run NA
SA244830Blank_4Empty run NA
SA244831Blank_8Empty run NA
SA244832Blank_6Empty run NA
SA244833Blank_5Empty run NA
SA244834MNBAL-165B_1Human BALF Bacterial
SA244835MNBAL-165C_1Human BALF Bacterial
SA244836MNBAL-165A_1Human BALF Bacterial
SA244837MNBAL-192A_1Human BALF Bacterial
SA244838MNBAL-198B_1Human BALF Bacterial
SA244839MNBAL-161C_1Human BALF Bacterial
SA244840MNBAL-198A_1Human BALF Bacterial
SA244841MNBAL-192C_1Human BALF Bacterial
SA244842MNBAL-192B_1Human BALF Bacterial
SA244843MNBAL-153B_2xprep_1Human BALF Bacterial
SA244844MNBAL-198C_1Human BALF Bacterial
SA244845MNBAL-153A_1Human BALF Bacterial
SA244846MNBAL-152C_1Human BALF Bacterial
SA244847MNBAL-153C_1Human BALF Bacterial
SA244848MNBAL-154A_1Human BALF Bacterial
SA244849MNBAL-161A_1Human BALF Bacterial
SA244850MNBAL-154C_1Human BALF Bacterial
SA244851MNBAL-154B_1Human BALF Bacterial
SA244852MNBAL-161B_1Human BALF Bacterial
SA244853MNBAL-5B_1Human BALF Bacterial
SA244854MNBAL-82A_1Human BALF Bacterial
SA244855MNBAL-77C_1Human BALF Bacterial
SA244856MNBAL-77B_1Human BALF Bacterial
SA244857MNBAL-82B_1Human BALF Bacterial
SA244858MNBAL-82C_1Human BALF Bacterial
SA244859MNBAL-97C_1Human BALF Bacterial
SA244860MNBAL-97B_1Human BALF Bacterial
SA244861MNBAL-97A_1Human BALF Bacterial
SA244862MNBAL-77A_1Human BALF Bacterial
SA244863MNBAL-76C_1Human BALF Bacterial
SA244864MNBAL-33B_1Human BALF Bacterial
SA244865MNBAL-33A_1Human BALF Bacterial
SA244866MNBAL-212B_1Human BALF Bacterial
SA244867MNBAL-33C_1Human BALF Bacterial
SA244868MNBAL-5A_1Human BALF Bacterial
SA244869MNBAL-76B_1Human BALF Bacterial
SA244870MNBAL-76A_1Human BALF Bacterial
SA244871MNBAL-152B_1Human BALF Bacterial
SA244872MNBAL-212A_1Human BALF Bacterial
SA244873MNBAL-212C_1Human BALF Bacterial
SA244874MNBAL-115B_1Human BALF Bacterial
SA244875MNBAL-108C_1Human BALF Bacterial
SA244876MNBAL-108B_1Human BALF Bacterial
SA244877MNBAL-111A_1Human BALF Bacterial
SA244878MNBAL-111B_1Human BALF Bacterial
SA244879MNBAL-115C_1Human BALF Bacterial
SA244880MNBAL-152A_1Human BALF Bacterial
SA244881MNBAL-111C_1Human BALF Bacterial
SA244882MNBAL-108A_1Human BALF Bacterial
SA244883MNBAL-115A_1Human BALF Bacterial
SA244884MNBAL-136B_1Human BALF Bacterial
SA244885MNBAL-136C_1Human BALF Bacterial
SA244886MNBAL-102C_1Human BALF Bacterial
SA244887MNBAL-136A_1Human BALF Bacterial
SA244888MNBAL-102B_1Human BALF Bacterial
SA244889MNBAL-102A_1Human BALF Bacterial
SA244890MNBAL-71C_1Human BALF Cocci
SA244891MNBAL-71B_1Human BALF Cocci
SA244892MNBAL-72B_1Human BALF Cocci
SA244893MNBAL-73A_1Human BALF Cocci
SA244894MNBAL-39C_1Human BALF Cocci
SA244895MNBAL-72A_1Human BALF Cocci
SA244896MNBAL-119C_1Human BALF Cocci
SA244897MNBAL-61A_1Human BALF Cocci
SA244898MNBAL-73B_1Human BALF Cocci
SA244899MNBAL-119B_1Human BALF Cocci
SA244900MNBAL-61B_1Human BALF Cocci
SA244901MNBAL-119A_1Human BALF Cocci
SA244902MNBAL-71A_1Human BALF Cocci
SA244903MNBAL-75A_1Human BALF Cocci
SA244904MNBAL-109B_1Human BALF Cocci
SA244905MNBAL-109C_1Human BALF Cocci
SA244906MNBAL-109A_1Human BALF Cocci
SA244907MNBAL-14A_1Human BALF Cocci
SA244908MNBAL-14C_1Human BALF Cocci
SA244909MNBAL-14B_1Human BALF Cocci
SA244910MNBAL-75C_1Human BALF Cocci
SA244911MNBAL-75B_1Human BALF Cocci
SA244912MNBAL-74B_1Human BALF Cocci
SA244913MNBAL-74A_1Human BALF Cocci
SA244914MNBAL-39B_1Human BALF Cocci
SA244915MNBAL-39A_1Human BALF Cocci
SA244916MNBAL-74C_1Human BALF Cocci
SA244917MNBAL-73C_1Human BALF Cocci
SA244918MNBAL-17A_1Human BALF Fungal
SA244919MNBAL-17B_1Human BALF Fungal
SA244920MNBAL-17C_1Human BALF Fungal
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