Summary of Study ST002456

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001584. The data can be accessed directly via it's Project DOI: 10.21228/M8Z71C This work is supported by NIH grant, U2C- DK119886.

See: https://www.metabolomicsworkbench.org/about/howtocite.php

This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.

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Study IDST002456
Study Title1H NMR metabolomics applied to assess the metabolic response of Ruditapes philippinarum clams to sea warming and 17-α-ethinylestradiol exposure
Study Type1H NMR metabolomics to study the effects of warming conditions and exposure to 17-α-ethinylestradiol (EE2) on the polar metabolome of Ruditapes philippinarum clams
Study SummaryIn this study, a comprehensive untargeted 1H NMR metabolomics strategy was applied to measure the metabolic impact of sea warming, in tandem with exposure to EE2, on Ruditapes philippinarum clams. The clams were exposed to five different EE2 concentrations: 0 (control group), 5, 25, 125 and 625 ng/L; either at 17 °C as control temperature or at 21 °C (representing a 4 °C increase, which corresponds to the worst-case warming scenario). The obtained data added important knowledge, unveiling individual metabolic effects of temperature rise and synergetic effects upon EE2 exposure, and paving the way for the definition of new metabolic markers for the monitoring of environmental stressors.
Institute
University of Aveiro
DepartmentCICECO – Aveiro Institute of Materials, Department of Chemistry
LaboratoryMetabolomics Group- CICECO
Last NameRodrigues
First NameJoao A.
AddressUniversity of Aveiro, Campus Universitario de Santiago, 3810-193 Aveiro, Portugal
Emailjoao.e.a.rodrigues@gmail.com
Phone00351963481841
Submit Date2023-01-26
Num Groups10
Total Subjects103
Study CommentsThis work was developed within the CICECO-Aveiro Institute of Materials project (UIDB/50011/2020, UIDP/50011/2020 & LA/P/0006/2020) financed by national funds through the FCT/MEC (PIDDAC). We are also grateful to the Portuguese National NMR Network (PTNMR), supported by FCT funds as the NMR spectrometer used is part of PTNMR and partially supported by Infrastructure Project No. 022161 (co-financed by FEDER through COMPETE 2020, POCI and PORL, and the FCT through PIDDAC). This work was also financially supported by the project BISPECIAl: BIvalveS under Polluted Environment and ClImate chAnge (POCI-01-0145-FEDER- 028425) funded by FEDER, through COMPETE2020 - Programa Operacional Competitividade e Internacionalização (POCI), and by national funds (OE), through FCT/MCTES. Mónica G. Silva benefited from Research Grant (MSc) (BI/CESAM/0043_2019/POCI-01-0145-FEDER-028425) under the project BISPECIAl: BIvalveS under Polluted Environment and ClImate change PTDC/CTA-AMB/28425/2017 (POCI-01-0145-FEDER-028425).
Raw Data AvailableYes
Raw Data File Type(s)fid
Analysis Type DetailNMR
Release Date2023-10-02
Release Version1
Joao A. Rodrigues Joao A. Rodrigues
https://dx.doi.org/10.21228/M8Z71C
ftp://www.metabolomicsworkbench.org/Studies/ application/zip

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Factors:

Subject type: Invertebrate; Subject species: Ruditapes philippinarum (Factor headings shown in green)

mb_sample_id local_sample_id Factor
SA245718bivalves_17C_C0_08bivalves_17C_C0
SA245719bivalves_17C_C0_10bivalves_17C_C0
SA245720bivalves_17C_C0_11bivalves_17C_C0
SA245721bivalves_17C_C0_07bivalves_17C_C0
SA245722bivalves_17C_C0_01bivalves_17C_C0
SA245723bivalves_17C_C0_09bivalves_17C_C0
SA245724bivalves_17C_C0_06bivalves_17C_C0
SA245725bivalves_17C_C0_02bivalves_17C_C0
SA245726bivalves_17C_C0_04bivalves_17C_C0
SA245727bivalves_17C_C0_03bivalves_17C_C0
SA245728bivalves_17C_C0_05bivalves_17C_C0
SA245729bivalves_17C_C125_04bivalves_17C_C125
SA245730bivalves_17C_C125_03bivalves_17C_C125
SA245731bivalves_17C_C125_01bivalves_17C_C125
SA245732bivalves_17C_C125_05bivalves_17C_C125
SA245733bivalves_17C_C125_02bivalves_17C_C125
SA245734bivalves_17C_C125_10bivalves_17C_C125
SA245735bivalves_17C_C125_11bivalves_17C_C125
SA245736bivalves_17C_C125_06bivalves_17C_C125
SA245737bivalves_17C_C125_09bivalves_17C_C125
SA245738bivalves_17C_C125_07bivalves_17C_C125
SA245739bivalves_17C_C125_08bivalves_17C_C125
SA245740bivalves_17C_C25_10bivalves_17C_C25
SA245741bivalves_17C_C25_09bivalves_17C_C25
SA245742bivalves_17C_C25_08bivalves_17C_C25
SA245743bivalves_17C_C25_12bivalves_17C_C25
SA245744bivalves_17C_C25_11bivalves_17C_C25
SA245745bivalves_17C_C25_03bivalves_17C_C25
SA245746bivalves_17C_C25_02bivalves_17C_C25
SA245747bivalves_17C_C25_07bivalves_17C_C25
SA245748bivalves_17C_C25_04bivalves_17C_C25
SA245749bivalves_17C_C25_01bivalves_17C_C25
SA245750bivalves_17C_C25_05bivalves_17C_C25
SA245751bivalves_17C_C25_06bivalves_17C_C25
SA245752bivalves_17C_C5_03bivalves_17C_C5
SA245753bivalves_17C_C5_04bivalves_17C_C5
SA245754bivalves_17C_C5_02bivalves_17C_C5
SA245755bivalves_17C_C5_05bivalves_17C_C5
SA245756bivalves_17C_C5_01bivalves_17C_C5
SA245757bivalves_17C_C5_07bivalves_17C_C5
SA245758bivalves_17C_C5_06bivalves_17C_C5
SA245759bivalves_17C_C5_10bivalves_17C_C5
SA245760bivalves_17C_C5_11bivalves_17C_C5
SA245761bivalves_17C_C5_09bivalves_17C_C5
SA245762bivalves_17C_C5_08bivalves_17C_C5
SA245763bivalves_17C_C625_08bivalves_17C_C625
SA245764bivalves_17C_C625_09bivalves_17C_C625
SA245765bivalves_17C_C625_11bivalves_17C_C625
SA245766bivalves_17C_C625_10bivalves_17C_C625
SA245767bivalves_17C_C625_07bivalves_17C_C625
SA245768bivalves_17C_C625_06bivalves_17C_C625
SA245769bivalves_17C_C625_01bivalves_17C_C625
SA245770bivalves_17C_C625_03bivalves_17C_C625
SA245771bivalves_17C_C625_02bivalves_17C_C625
SA245772bivalves_17C_C625_04bivalves_17C_C625
SA245773bivalves_17C_C625_05bivalves_17C_C625
SA245774bivalves_21C_C0_07bivalves_21C_C0
SA245775bivalves_21C_C0_08bivalves_21C_C0
SA245776bivalves_21C_C0_09bivalves_21C_C0
SA245777bivalves_21C_C0_06bivalves_21C_C0
SA245778bivalves_21C_C0_10bivalves_21C_C0
SA245779bivalves_21C_C0_05bivalves_21C_C0
SA245780bivalves_21C_C0_01bivalves_21C_C0
SA245781bivalves_21C_C0_02bivalves_21C_C0
SA245782bivalves_21C_C0_03bivalves_21C_C0
SA245783bivalves_21C_C0_04bivalves_21C_C0
SA245784bivalves_21C_C125_03bivalves_21C_C125
SA245785bivalves_21C_C125_01bivalves_21C_C125
SA245786bivalves_21C_C125_04bivalves_21C_C125
SA245787bivalves_21C_C125_02bivalves_21C_C125
SA245788bivalves_21C_C125_06bivalves_21C_C125
SA245789bivalves_21C_C125_05bivalves_21C_C125
SA245790bivalves_21C_C125_08bivalves_21C_C125
SA245791bivalves_21C_C125_09bivalves_21C_C125
SA245792bivalves_21C_C125_07bivalves_21C_C125
SA245793bivalves_21C_C25_07bivalves_21C_C25
SA245794bivalves_21C_C25_08bivalves_21C_C25
SA245795bivalves_21C_C25_06bivalves_21C_C25
SA245796bivalves_21C_C25_09bivalves_21C_C25
SA245797bivalves_21C_C25_02bivalves_21C_C25
SA245798bivalves_21C_C25_05bivalves_21C_C25
SA245799bivalves_21C_C25_03bivalves_21C_C25
SA245800bivalves_21C_C25_01bivalves_21C_C25
SA245801bivalves_21C_C25_04bivalves_21C_C25
SA245802bivalves_21C_C5_04bivalves_21C_C5
SA245803bivalves_21C_C5_02bivalves_21C_C5
SA245804bivalves_21C_C5_01bivalves_21C_C5
SA245805bivalves_21C_C5_05bivalves_21C_C5
SA245806bivalves_21C_C5_03bivalves_21C_C5
SA245807bivalves_21C_C5_06bivalves_21C_C5
SA245808bivalves_21C_C5_09bivalves_21C_C5
SA245809bivalves_21C_C5_10bivalves_21C_C5
SA245810bivalves_21C_C5_07bivalves_21C_C5
SA245811bivalves_21C_C5_08bivalves_21C_C5
SA245812bivalves_21C_C625_07bivalves_21C_C625
SA245813bivalves_21C_C625_08bivalves_21C_C625
SA245814bivalves_21C_C625_09bivalves_21C_C625
SA245815bivalves_21C_C625_06bivalves_21C_C625
SA245816bivalves_21C_C625_03bivalves_21C_C625
SA245817bivalves_21C_C625_01bivalves_21C_C625
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