Summary of Study ST000272
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR000216. The data can be accessed directly via it's Project DOI: 10.21228/M8GC7P This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
Study ID | ST000272 |
Study Title | Acyl-carnitine analysis (plasma) |
Study Type | Adipose Acyl-carnitines |
Study Summary | To understand the contribution of adipose tissue fatty acid oxidation to whole-body metabolism, we generated mice with an adipose-specific knockout of carnitine palmitoyltransferase 2 (CPT2A?/?), an obligate step in mitochondrial long-chain fatty acid oxidation. CPT2A?/? mice became hypothermic after an acute cold challenge, and CPT2A?/? brown adipose tissue (BAT) failed to upregulate thermogenic genes in response to agonist-induced stimulation. The adipose-specific loss of CPT2 resulted in diet-dependent changes in adiposity but did not result in changes in body weight on low- or high-fat diets. Additionally, CPT2A?/? mice had suppressed high-fat diet-induced oxidative stress and inflammation in visceral white adipose tissue (WAT); however, high-fat diet-induced glucose intolerance was not improved. These data show that fatty acid oxidation is required for cold-induced thermogenesis in BAT and high-fat diet-induced oxidative stress and inflammation in WAT. http://www.sciencedirect.com/science/article/pii/S2211124714010523 |
Institute | University of Michigan |
Department | Biological Chemistry(Johns Hopkins University School of Medicine) |
Laboratory | Wolfgang Lab(Johns Hopkins University School of Medicine) |
Last Name | Wolfgang |
First Name | Michael |
Address | 733 North Broadway, Suite G49 Baltimore, MD 21205-2196 |
mwolfga1@jhmi.edu | |
Phone | 443-287-7680 |
Submit Date | 2014-02-21 |
Num Groups | 2 |
Total Subjects | 16 |
Study Comments | (CPT2A?/?) stands for Carnitine palmitoyltransferase 2 knock out |
Raw Data File Type(s) | d |
Analysis Type Detail | LC-MS |
Release Date | 2016-01-06 |
Release Version | 1 |
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Project:
Project ID: | PR000216 |
Project DOI: | doi: 10.21228/M8GC7P |
Project Title: | Adipose Oxidation |
Project Summary: | Role of Fatty Acid Oxidation in Adipose Tissue |
Institute: | Johns Hopkins University |
Department: | Biological Chemistry |
Laboratory: | Wolfgang Lab |
Last Name: | Wolfgang |
First Name: | Michael |
Address: | 733 North Broadway, Suite G49 Baltimore, MD 21205-2196 |
Email: | mwolfga1@jhmi.edu |
Phone: | 443-287-7680 |