Summary of Study ST001151
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR000770. The data can be accessed directly via it's Project DOI: 10.21228/M8509V This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
Study ID | ST001151 |
Study Title | 4-day dietary effect of fast food vs Mediterranean diet to HDL lipidome |
Study Type | Dietary intervention study |
Study Summary | In this randomized order cross-over study, ten healthy subjects consumed a Mediterranean (Med) and a fast food (FF) diet for 4 days, with a 4-day wash-out between treatments. Lipidomic composition was analyzed in isolated HDL fractions by an untargeted LC-MS method with 15 internal standards. HDL PE content was increased by FF diet, and 41 out of 170 lipid species were differentially affected by diet. Saturated fatty acids (FA) and odd chain FA were enriched after FF diet, while very-long chain FA and unsaturated FA were enriched after Med diet. The composition of PC, TG and CE were significantly altered to reflect the FA composition of the diet whereas the composition of SM and ceramides were generally unaffected, indicating that glycerolipids may be sensitive markers of dietary intake, whereas sphingolipids are more indicative of non-dietary factors. Results from this study indicate that the HDL lipidome is widely remodeled within 4 days of diet change and that certain lipid classes are more sensitive markers of diet whereas other lipid classes are better indicators of non-dietary factors |
Institute | University of California, Davis |
Department | Nutrition |
Laboratory | Zivkovic |
Last Name | Zivkovic |
First Name | Angela |
Address | 3402 Meyer hall, Davis, CA, 95616, USA |
amzivkovic@ucdavis.edu | |
Phone | +1(530)752-3973 |
Submit Date | 2019-03-14 |
Num Groups | 4 |
Total Subjects | 10 |
Num Males | 5 |
Num Females | 5 |
Raw Data Available | Yes |
Raw Data File Type(s) | d |
Analysis Type Detail | LC-MS |
Release Date | 2019-09-23 |
Release Version | 1 |
Select appropriate tab below to view additional metadata details:
Project:
Project ID: | PR000770 |
Project DOI: | doi: 10.21228/M8509V |
Project Title: | Fast Food Project |
Project Type: | Dietary intervention study |
Project Summary: | A human study looks at 4-day effect of fast food vs Mediterranean to HDL composition and function, host metabolome and gut microbiome |
Institute: | University of California, Davis |
Department: | Department of nutrition |
Laboratory: | Zivkovic |
Last Name: | Zivkovic |
First Name: | Angela |
Address: | 3402 Meyer hall, Davis, CA, 95616, USA |
Email: | amzivkovic@ucdavis.edu |
Phone: | +1(530)752-3973 |