Summary of Study ST002180
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001338. The data can be accessed directly via it's Project DOI: 10.21228/M8RX2S This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.
Study ID | ST002180 |
Study Title | Global, distinctive and personal changes in molecular and microbial profiles induced by specific fibers in humans (Targeted) |
Study Summary | Dietary fibers act through the microbiome and improve cardiovascular health, metabolic disorders and cancer prevention. To understand health benefits of dietary fiber supplementation we investigated two popular purified fibers, arabinoxylan (AX) and long-chain inulin (LCI), and a mixture of five fibers. We present multi-omic signatures of metabolomics, lipidomics, proteomics, metagenomics, a cytokine panel and clinical measurements on healthy and insulin resistant participants. Each fiber is associated with fiber-dependent biochemical and microbial responses. AX consumption associates with a significant reduction in LDL and an increase in bile acids, contributing to its observed cholesterol reduction. LCI is associated with an increase in Bifidobacterium. However, at the highest LCI dose there is increased inflammation and elevation in the liver enzyme alanine aminotransferase. This study yields insights into the effects of fiber supplementation, it provides insights into mechanisms behind fiber induced cholesterol reduction, and it shows effects of individual, purified fibers on the microbiome. |
Institute | Stanford University |
Last Name | Lancaster |
First Name | Samuel |
Address | 240 Pasteur Dr, BMI bldg 4400, Stanford California, 94305 |
slancast@stanford.edu | |
Phone | 6126004033 |
Submit Date | 2022-03-18 |
Raw Data Available | Yes |
Raw Data File Type(s) | mzML |
Analysis Type Detail | LC-MS |
Release Date | 2022-07-15 |
Release Version | 1 |
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Project:
Project ID: | PR001338 |
Project DOI: | doi: 10.21228/M8RX2S |
Project Title: | Health benefits of dietary fiber supplementation. |
Project Summary: | Untargeted metabolomics to understand health benefits of dietary fiber supplementation. |
Institute: | Stanford University |
Last Name: | Lancaster |
First Name: | Samuel |
Address: | 240 Pasteur Dr, BMI bldg 4400, Stanford California, 94305 |
Email: | slancast@stanford.edu |
Phone: | 6126004033 |