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MB Sample ID: SA084169
Local Sample ID: | DMSO_u6h_c |
Subject ID: | SU001269 |
Subject Type: | Cultured cells |
Subject Species: | Plasmodium falciparum;Homo sapiens |
Taxonomy ID: | 5833;9606 |
Genotype Strain: | 3D7 |
Age Or Age Range: | 6-12 h post invasion |
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Treatment:
Treatment ID: | TR001284 |
Treatment Summary: | Ring stage P. falciparum infected RBCs (10% parasitaemia and 2% Hct) were treated with OZ277 (1 uM), OZ439 (1 uM), DHA (300 nM) or an equivalent volume of DMSO (0.03%). DHA-treated cultures were incubated with drug for 0, 1.5, 3 and 6 h. OZ277- and OZ439-treated cultures were incubated with drug for 0, 3, 6 and 9 h. During the drug incubation period parasites were at 37°C under a gas atmosphere of 94% N2, 5% CO2 and 1% O2. |
Treatment Compound: | OZ277 (arterolane), OZ439 (artefenomel) and dihydroartemisinin (DHA) |
Treatment Vehicle: | DMSO |
Cell Media: | Complete RPMI medium (10.4 g/L) containing HEPES (5.94 g/L), hypoxanthine (50 mg/L), sodium bicarbonate (2.1 g/L) and Albumax II (5 g/L). |
Cell Media Lastchanged: | Immediately prior to initiation of drug incubation |