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MB Sample ID: SA137226
| Local Sample ID: | CLTI Pre-surgery1B |
| Subject ID: | SU001694 |
| Subject Type: | Human |
| Subject Species: | Homo sapiens |
| Taxonomy ID: | 9606 |
| Age Or Age Range: | 55-82 years |
| Gender: | Male and female |
| Human Race: | unknown |
| Human Ethnicity: | unknown |
| Human Medications: | Asprin, ACE inhibitor, statins, cilostazol |
| Human Smoking Status: | Controls = 4, CLTI Pre-surgery = 7, and CLTI Amputation = 9 |
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Treatment:
| Treatment ID: | TR001707 |
| Treatment Summary: | This was a prospective cohort study that examined the metabolomic profile of skeletal muscle from CLTI patients undergoing surgerical intervention or amputation, as well as a cohort of non-PAD controls. CLTI patients exhibited severe symptomology (Rutherford Classification 3-6), with high incidence of common PAD risk factors including hypertension, hyperlipidemia, coronary artery disease, and diabetes.Ten patients with critical limb ischemia (CLI) undergoing surgical intervention (CLTI Pre-surgery), and ten CLI patients undergoing limb amputation (CLTI Amputation). Five pre-surgery patients underwent bypass interventions and five underwent endovascular procedures. Muscle specimens were collected within the confines of the operating rooms (CLI patients) or via percutaneous muscle biopsy using sterile procedures. |
| Human Fasting: | non-fasted |
| Human Endp Clinical Signs: | N/A |
