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MB Sample ID: SA196107

Local Sample ID:	1922
Subject ID:	SU002158
Subject Type:	Human
Subject Species:	Homo sapiens
Taxonomy ID:	9606
Gender:	Male and female

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Treatment:

Treatment ID:	TR002170
Treatment Summary:	The capsule sampling device (CapScan®, Envivo Bio Inc, San Carlos CA) consists of a one-way valve capping a hollow elastic bladder. The device is prepared for packaging by evacuating the elastic bladder, folding it in half, and packaging the folded device inside a dissolvable capsule measuring 6.5 mm in diameter×23 mm long, onto which an enteric coating is applied. The target pH was pH 6 for type 1 and type 2 capsules, and pH 7.5 for type 3 and type 4, with type 2 and type 4 having a thicker coating to result in delayed opening. The elastic bladder then unfolds and expands into a tube 6 mm in diameter and 33 mm long, thereby drawing in ~300 µL of gut luminal contents through the one-way valve. The one-way valve maintains the integrity of the sample collected inside the bladder as the device moves through the colon and is exposed to stool.

Treatment ID:

TR002170

Treatment Summary:

The capsule sampling device (CapScan®, Envivo Bio Inc, San Carlos CA) consists of a one-way valve capping a hollow elastic bladder. The device is prepared for packaging by evacuating the elastic bladder, folding it in half, and packaging the folded device inside a dissolvable capsule measuring 6.5 mm in diameter×23 mm long, onto which an enteric coating is applied. The target pH was pH 6 for type 1 and type 2 capsules, and pH 7.5 for type 3 and type 4, with type 2 and type 4 having a thicker coating to result in delayed opening. The elastic bladder then unfolds and expands into a tube 6 mm in diameter and 33 mm long, thereby drawing in ~300 µL of gut luminal contents through the one-way valve. The one-way valve maintains the integrity of the sample collected inside the bladder as the device moves through the colon and is exposed to stool.