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MB Sample ID: SA205295
Local Sample ID: | T11_6 |
Subject ID: | SU002222 |
Subject Type: | Mammal |
Subject Species: | Mus musculus |
Taxonomy ID: | 10090 |
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Treatment:
Treatment ID: | TR002234 |
Treatment Summary: | TKO p53LSL R172H/+ Dicer1flox/flox Ptenflox/flox Amhr2cre/+ mice were generated by mating p53LSL-R172H/+Dicer1flox/floxPtenflox/flox female mice with Dicer1flox/floxPtenflox/floxAmhr2cre/+ male mice. For TKO controls, p53LSL-R172H/+Dicer1flox/floxPtenflox/flox were generated. TKO control mice carry the same genetic makeup as TKO mice but do not develop HGSC. A sequential serum collection protocol was conducted to collect samples from TKO and TKO controls every two weeks starting at 8 weeks of age until a humane end point for sacrifice or development of ascites. TKO mice were sacrificed at Indiana University School of Medicine in accordance with animal protocol (21124) approved by the IACUC. |