Summary of Study ST000165
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR000143. The data can be accessed directly via it's Project DOI: 10.21228/M8GP4N This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
Download additional data: the amino acids were measured under negative ion chemical ionisation conditions using isobutane as reactant gas
| Study ID | ST000165 |
| Study Title | Sparing of muscle mass and function by passive loading in an experimental intensive care unit model |
| Study Type | time course + intervention |
| Study Summary | A unique experimental rat ICU model has been used allowing long-term (weeks) time-resolved analyses of the effects of standardized unilateral passive mechanical loading on skeletal muscle size and function and underlying mechanisms. Results show that passive mechanical loading alleviated the muscle wasting and the loss of force-generation associated with the ICU intervention, resulting in a doubling of the functional capacity of the loaded versus the unloaded muscles after a 2-week ICU intervention. |
| Institute | Uppsala University |
| Department | Department of Neuroscience |
| Last Name | Larsson |
| First Name | Lars |
| Lars.larsson@neuro.uu.se | |
| Submit Date | 2015-05-14 |
| Num Groups | 2 |
| Total Subjects | 13 |
| Raw Data Available | No |
| Analysis Type Detail | IR-MS |
| Release Date | 2015-05-10 |
| Release Version | 1 |
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Treatment:
| Treatment ID: | TR000190 |
| Treatment Summary: | Mechanical stimulation|Sham operation |
| Treatment Protocol Comments: | Sham operated controls and 46 anaesthetized and mechanically ventilated female SpragueDawley rats treated with ?-cobratoxin for durations varying from 6 h to 14 days were included in this study. The experimental model has previously been described in detail (Dworkin & Dworkin, 1990, 2004). For mechanical stimulation animals, left leg was mechanically stimulated and right leg was not. |Sham operated controls and 46 anaesthetized and mechanically ventilated female SpragueDawley rats treated with ?-cobratoxin for durations varying from 6 h to 14 days were included in this study. The experimental model has previously been described in detail (Dworkin & Dworkin, 1990, 2004). For sham operated controls, no stimulation was performed on either legs |
