Summary of Study ST001846
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001163. The data can be accessed directly via it's Project DOI: 10.21228/M8CH74 This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.
Study ID | ST001846 |
Study Title | Proteasome Inhibitor Related Cardiotoxicity (part I) |
Study Summary | BALB/c mice were injected with CFZ (16 mg/kg, iv), BTZ (1 mg/kg, iv), CFZ/atRA (CFZ: 16 mg/kg iv, atRA: 1 mg/kg iv) or Captisol (Vehicle, iv) (6 mice per cohort). ECGs were recorded under anesthesia at the end of 1h treatment and the mice were sacrificed by cervical dislocation. Hearts were extracted and were frozen and stored at -80°C until analysis |
Institute | University of Zurich |
Last Name | Mendez |
First Name | Max |
Address | Rorschacherstrasse 95. 9007, St.Gallen |
maxmendez@runbox.com | |
Phone | +41 71 494 10 67 |
Submit Date | 2021-06-01 |
Num Groups | 4 |
Total Subjects | 24 |
Num Females | 24 |
Raw Data Available | Yes |
Raw Data File Type(s) | mzXML |
Analysis Type Detail | LC-MS |
Release Date | 2022-12-01 |
Release Version | 1 |
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Treatment:
Treatment ID: | TR001935 |
Treatment Summary: | Injections with CFZ (16 mg/kg, iv), BTZ (1 mg/kg, iv), CFZ+atRA (CFZ: 16 mg/kg iv, atRA: 1 mg/kg iv) or Captisol (Vehicle, iv) |
Treatment Compound: | Bortezomib (PS-34, Selleck Chemicals, S1013); Carfilzomib (PR-171, Selleck Chemicals, S2853); all-trans-Retinoic-Acid (Sigma-Aldrich, R2625); Captisol (Ligand Pharmaceuticals |
Treatment Route: | i.v |
Treatment Dose: | As described in treatment summary |
Treatment Vehicle: | Captisol |
Animal Anesthesia: | Induction with Ketamine 80 mg/kg intramuscular and maintained with Isoflurane 0.5% |
Animal Endp Euthanasia: | 1h |
Animal Endp Tissue Coll List: | 1h |