Summary of Study ST002554
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001646. The data can be accessed directly via it's Project DOI: 10.21228/M8XX43 This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.
| Study ID | ST002554 |
| Study Title | Untargeted lipidomic analysis of blood plasma samples from drug-naïve patients with bipolar disorder and schizophrenia |
| Study Type | Untargeted lipidomic analysis |
| Study Summary | In this study, we obtained a lipidomic profile of plasma samples from patients with schizophrenia (SZ) and bipolar disorder (BD) in comparison to healthy controls (CT). The sample cohort consisted of 60 drug-naïve patients and 30 control individuals. Untargeted lipidomics strategy using liquid chromatography coupled to high resolution mass spectrometry was employed to obtain the data, and univariate and multivariate statistical tools were applied to evaluate the results. Metabolic pathway networks were constructed and our results demonstrated alterations in different lipid pathways, such as glycerophospholipids, sphingolipids, and prostaglandins between schizophrenia and bipolar disorder patients. The differential diagnosis is crucial for effective treatment and improving the quality of life of patients with psychotic disorders. |
| Institute | University of Campinas |
| Department | Institute of Chemistry |
| Laboratory | LaBIOmics - Laboratory of Bioanalytics and Integrated Omics |
| Last Name | Brixner Riça |
| First Name | Larissa |
| Address | Laboratório B-211 a 215 - Instituto de Química, R. Josué de Castro, 126-336 - Cidade Universitária, Campinas - SP |
| larissabrixner@gmail.com | |
| Phone | +55 19 35213060 |
| Submit Date | 2023-04-04 |
| Num Groups | 3 |
| Total Subjects | 90 |
| Num Males | 42 |
| Num Females | 48 |
| Raw Data Available | Yes |
| Raw Data File Type(s) | mzML |
| Analysis Type Detail | LC-MS |
| Release Date | 2023-06-25 |
| Release Version | 1 |
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Treatment:
| Treatment ID: | TR002666 |
| Treatment Summary: | The study was conducted at the Institute of Psychiatry, University of Sao Paulo, Brazil. The sample consisted of 60 drug-naïve patients (30 SZ and 30 BD) and 30 healthy controls (CT). All participants were under 60 years old and were middle-income, community-dwelling subjects from the hospital catchment area. SZ diagnosis was established according to the Diagnostic and Statistical Manual of Mental Disorders (DSM-IV) (Bell, 1994) and SCID-I/P-Structured Clinical Interview Disorders Axis I for DSM-IV version 2.0 (First, 1997) was used to confirm the diagnosis. Psychopathology was assessed using the Positive and Negative Symptoms Scale (PANSS) (Kay et al., 1987) including the positive and negative subscales and general psychopathology. Depressive and manic symptoms were assessed for BD patients by the Hamilton Depression Rating Scale (HAM-D) (Hamilton, 1960) and Young's Mania Rating Scale (YMRS) (Young et al., 1978). Subjects with other psychiatric or neurological disorders were excluded. References cited: Bell, C.C. DSM-IV: Diagnostic and Statistical Manual of Mental Disorders. JAMA 1994, 272, 828–829. Spitzer, M.; Robert, L.; Gibbon, M.; Williams, J. Structured Clinical Interview for DSM-IV-TR Axis I Disorders, Research Version, Non-Patient Edition (SCID-I/NP). New York: Biometrics Research, New York State Psychiatric Institute 2002. Kay, S.R.; Fiszbein, A.; Opler, L.A. The Positive and Negative Syndrome Scale (PANSS) for Schizophrenia. Schizophr Bull 1987, 13, 261–276. Hamilton, M. A RATING SCALE FOR DEPRESSION. J Neurol Neurosurg Psychiatry 1960, 23, 56–62. |
| Human Fasting: | 8 h |
