Summary of project PR000066

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR000066. The data can be accessed directly via it's Project DOI: 10.21228/M8QG6H This work is supported by NIH grant, U2C- DK119886.

See: https://www.metabolomicsworkbench.org/about/howtocite.php

Project ID: PR000066
Project DOI:doi: 10.21228/M8QG6H
Project Title:Metabolomic profiling of influenza: a 2009 pandemic H1N1 influenza in lean and obese mice
Project Type:Effects and role of obesity on the severity of influenza
Project Summary:During the 2009 H1N1 influenza pandemic outbreak, obese individuals were reported to be at greater risk for morbidity and mortality from pandemic infection. However, the mechanisms contributing to greater influenza severity in infected obese individuals remain unclear. Given that one in ten individuals is obese, and worldwide influenza outbreaks are a consistent public health burden, garnering a better understanding of the pathways and mechanisms contributing to greater influenza severity in the obese is essential for limiting influenza infection mortality in this at-risk population. Closely paralleling pH1N1 infection outcome in humans, obese mice exhibit increased morbidity and mortality following pH1N1 infection. In mice, obesity impairs the function of natural killer cells, dendritic cells, macrophage, B cells and memory T cells. Further, several analyses of lung antiviral responses revealed that obese mice have greater lung damage, lung immune cell infiltration and impaired lung healing after infection. Nevertheless, it remains unclear how altered immune cell function contributes to greater lung damage and increased infection severity in obese mice. Metabolomics will be used to dissect the metabolic consequences of obesity on the immune response to pH1N1 infection. We will compare metabolic profiles of lung-specific and peripheral samples from uninfected and infected lean and obese mice during early and late phases of influenza immunity.
Institute:University of North Carolina at Chapel Hill
Department:Department of Nutrition
Last Name:Beck
First Name:Melinda
Address:2303 MHRB, CB #7461, UNC, Chapel Hill NC 27599
Email:melinda_beck@unc.edu
Phone:919-966-6809

Summary of all studies in project PR000066

Study IDStudy TitleSpeciesInstituteAnalysis
(* : Contains Untargted data)
Release
Date
VersionSamplesDownload
(* : Contains raw data)
ST000069 Metabolomic profiling of influenza: a 2009 pandemic H1N1 influenza in lean and obese mice (via blood and tissue) Mus musculus University of North Carolina MS 2015-06-01 1 70 Uploaded data (6.3M)
ST000070 Metabolomic profiling of influenza: a 2009 pandemic H1N1 influenza in lean and obese mice (via tissue) Mus musculus University of North Carolina MS 2015-07-01 1 37 Uploaded data (5.7M)
ST000071 Metabolomic profiling of influenza: a 2009 pandemic H1N1 influenza in lean and obese mice (via Urine) Mus musculus University of North Carolina MS 2015-07-31 1 25 Uploaded data (3.1M)
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