Summary of project PR000087

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR000087. The data can be accessed directly via it's Project DOI: 10.21228/M8F30Z This work is supported by NIH grant, U2C- DK119886.

See: https://www.metabolomicsworkbench.org/about/howtocite.php

Project ID: PR000087
Project DOI:doi: 10.21228/M8F30Z
Project Title:Dysfunctional lipid metabolism underlies the effect of perinatal DDT exposure on the development of metabolic syndrome
Project Type:Animal chemical exposure and feeding study
Project Summary:This study evaluated the effect of perinatal DDT exposure on metabolic syndrome in mice exposed to doses that mimicked human exposure. The samples tested were from 2 groups: 1) a group with perinatal exposure to DDT consuming a high fat diet (DDHF), 2) a control group consuming a high fat diet (CHF). Results indicated the DDHF group had comparatively elevated plasma concentrations of glucose, insulin, cholesterol, and triglycerides, CYP7A1 gene expression, homeostasis model assessment- insulin resistance (HOMA-IR), and fat mass (%), as well as reduced thermogenesis. These data suggest perinatal DDT exposure may cause the co-occurrence of conditions associated with metabolic syndrome, including glucose intolerance, hyperinsulinemia, and dyslipidemia, impaired thermogenesis, and obesity.
Institute:University of California, Davis
Department:Environmental Toxicology
Laboratory:La Merrill
Last Name:La Merrill
First Name:Michele
Address:1 Shields Ave, Davis CA
Email:mlamerrill@ucdavis.edu
Phone:+1-530-754-7254
Funding Source:National Institute of Health (R00 ES019919, R03 DK082724, U24 DK092993, U24 DK097154, T32 ES007059, and P60 DK020541), the American Diabetes Association, and USDA-ARS intramural Project 5306-51530-019-00D

Summary of all studies in project PR000087

Study IDStudy TitleSpeciesInstituteAnalysis
(* : Contains Untargted data)
Release
Date
VersionSamplesDownload
(* : Contains raw data)
ST000095 Dysfunctional lipid metabolism underlies the effect of perinatal DDT exposure on the development of metabolic syndrome Mus musculus University of California, Davis MS 2015-02-03 1 15 Uploaded data (22.1M)*
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