Summary of project PR000287

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench,, where it has been assigned Project ID PR000287. The data can be accessed directly via it's Project DOI: 10.21228/M8Z310 This work is supported by NIH grant, U2C- DK119886.


Project ID: PR000287
Project DOI:doi: 10.21228/M8Z310
Project Title:Characterization and Plasticity of the Metabolome in Peripheral Cells in Bipolar I Disorder
Project Type:Broad Spectrum LCMS
Project Summary:Bipolar disorder is a serious condition characterized by severe and debilitating elevations and depressions in mood and energy (1). Bipolar I disorder (BPI) is a particularly severe phenotype which is generally defined as having periods of abnormal moods ranging from “highs,” (mania or hypomania), to “lows” (depression), alternating with periods of relatively normal moods. Key problems in treating bipolar disorder relate to the fact that the pathophysiology of the disorder remains elusive; as a result, there are currently no laboratory tests for diagnosis, to aid treatment decisions, or to predict treatment responses. Recent advances in the study of bipolar disorder increasingly implicate mitochondrial and bioenergetic dysfunction as a common feature of the pathophysiology of the disorder (2). Shifts in metabolism from mitochondrial oxidative phosphorylation toward glycolysis have been observed in the brains of bipolar patients experiencing depressive mood states (3). Increased oxidative stress has also been shown in postmortem brain from bipolar patients (4), and in cultured peripheral fibroblasts from patients with major depression (5). However, little is known about the inherent metabolic state of peripheral cells during bipolar disorder, which may reflect the overall metabolic profile of the individual and may also impact the supply of nutrients to the brain. We propose to characterize the baseline metabolomic profiles of peripheral cells in cultured fibroblasts from patients with BPI and matched non-affected controls. Patients with Bipolar I Disorder (BPI) and matched non-affected controls were recruited. Males and females from all races and ethnicities between the ages of 19-65 participated in the research. Skin biopsies were obtained and fibroblasts were isolated from each of these biopsies. A total of 1 x 〖10〗^7 fibroblasts cells were used for metabolomics. Cell pellets were flash frozen in liquid nitrogen and shipped on dry ice to the NIH Eastern Regional Comprehensive Metabolomic Resource Core at RTI International in North Carolina. Metabolomics will be determined using a broad spectrum metabolomics protocol by RTI.
Institute:University of Alabama, Birmingham
Department:School of Medicine
Laboratory:Department of Pathology
Last Name:Landar
First Name:Aimee
Address:BMR2 506 901 9th St South, Birmingham AL 35205
Funding Source:NIH, Common Fund, Pilot and Feasibility

Summary of all studies in project PR000287

Study IDStudy TitleSpeciesInstituteAnalysis
(* : Contains Untargted data)
(* : Contains raw data)
ST000361 Characterization and Plasticity of the Metabolome in Peripheral Cells in Bipolar I Disorder Homo sapiens University of North Carolina MS* 2017-03-03 1 23 Uploaded data (38.8G)*