Summary of project PR000340

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR000340. The data can be accessed directly via it's Project DOI: 10.21228/M85G6J This work is supported by NIH grant, U2C- DK119886.

See: https://www.metabolomicsworkbench.org/about/howtocite.php

Project ID: PR000340
Project DOI:doi: 10.21228/M85G6J
Project Title:Metabolomic Profiling of the Malaria Box Reveals Antimalarial Target Pathways
Project Summary:Here we interrogated the in vitro metabolic effects of 189 drugs (including 169 of the drug-like compounds from the Malaria Box) using ultra-high performance liquid chromatography mass-spectrometry (UHPLC-MS). The resulting metabolic fingerprints provide information on the parasite biochemical pathways affected by pharmacologic intervention and offer a critical blueprint for selecting and advancing lead compounds as next-generation antimalarial drugs. Our results reveal several major classes of metabolic disruption, which allow us to predict the mode-of-action (MoA) for many of the Malaria Box compounds.
Institute:Pennsylvania State University
Last Name:LlinĂ¡s
First Name:Manuel
Address:W126 Millenium Science Complex, University Park, PA 16802
Email:manuel@psu.edu
Phone:(814) 867-3527

Summary of all studies in project PR000340

Study IDStudy TitleSpeciesInstituteAnalysis
(* : Contains Untargted data)
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Date
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(* : Contains raw data)
ST000441 Metabolomic Profiling of the Malaria Box Reveals Antimalarial Target Pathways Plasmodium falciparum Pennsylvania State University MS 2016-12-22 1 189 Uploaded data (553.8K)
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