Summary of project PR000351

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench,, where it has been assigned Project ID PR000351. The data can be accessed directly via it's Project DOI: 10.21228/M8PC8X This work is supported by NIH grant, U2C- DK119886.


Project ID: PR000351
Project DOI:doi: 10.21228/M8PC8X
Project Title:Utilizing Metabolomics to Understand Novel Anti-Desmoid Tumor Drugs
Project Summary:Desmoid tumors (DT) are locally invasive soft tissue growths with no directed therapies currently. While two genes (β-catenin and adenomatous polyposis coli) have been found in patients who develop desmoids, it is unclear how these mutations and other downstream mechanisms lead to desmoid tumorigenesis. Extensive research has been explored in the molecular biology of desmoids; however, the use of metabolomics to understand the how the low molecular weight complements of cells, tissues, and biological fluids are perturbed by this highly localized disease. Additionally, the Desmoid Collaboration for a Cure has identified 45 active drugs against primary cell lines. It is unclear how these therapies perturb the metabolome, outside the Wnt and notch pathways.
Institute:RTI International
Last Name:Mercier
First Name:Kelly
Address:3040 E. Cornwallis Road

Summary of all studies in project PR000351

Study IDStudy TitleSpeciesInstituteAnalysis
(* : Contains Untargted data)
(* : Contains raw data)
ST000454 Utilizing Metabolomics to Understand Novel Anti-Desmoid Tumor Drugs (part I) Homo sapiens RTI International NMR 2018-02-07 1 69 Uploaded data (36.6M)*
ST000455 Utilizing Metabolomics to Understand Novel Anti-Desmoid Tumor Drugs (part II) Homo sapiens RTI International NMR 2017-12-06 1 51 Uploaded data (27.5M)*