Summary of project PR000458

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench,, where it has been assigned Project ID PR000458. The data can be accessed directly via it's Project DOI: 10.21228/M8VG74 This work is supported by NIH grant, U2C- DK119886.


Project ID: PR000458
Project DOI:doi: 10.21228/M8VG74
Project Title:Biomarkers of diabetes risk in children: role of obesity and exercise
Project Summary:This proposal addresses a gap in knowledge about biomarkers for insulin resistance and diabetes. It remains unclear why some populations develop diabetes at higher rates than others and whether prevention and treatment strategies should also differ. The main goal of the current study is to determine the impact of body composition and physical activity on biomarkers for insulin resistance in American Indian adolescents. We propose to use a targeted metabolomic approach to measure amino compounds and fatty acids in plasma. We will address these goals by exploring two Specific Aims: 1. To determine the effects of obesity and physical activity on circulating biomarkers for diabetes and metabolic disease risk in American Indian youth. Plasma samples used for measurements of amino compounds and fatty acids will be acquired from boys and girls 11-21 years old classified as, a) obese, low habitual physical activity and low fitness; b) normal weight, low habitual physical activity and low fitness; or, c) normal weight, high habitual physical activity and high fitness. 2. To determine the impact of exercise training on circulating biomarkers for diabetes and metabolic disease risk in obese American Indian youth. The same obese group tested in the cross-sectional comparison in Aim 1 will complete 16 weeks of aerobic exercise training. Plasma samples acquired before and after training will be used to measure amino compounds and fatty acids. The results of this project will provide novel information about the metabolic changes associated with insulin resistance, obesity, and physical activity in young people who are at risk for, but have not yet developed cardiometabolic disease. The study design takes advantage of, and supports the scientific partnership among investigators at the University of Oklahoma Health Sciences Center, Choctaw Nation of Oklahoma, and Mayo Clinic Rochester. This will set the stage for future lifestyle intervention studies to further explore the concepts outlined in this proposal.
Institute:Mayo Clinic
Last Name:Short
First Name:Kevin
Address:University of Oklahoma Health Sciences Center 1200 Children’s Ave, Suite 4500 Oklahoma City, OK 73104

Summary of all studies in project PR000458

Study IDStudy TitleSpeciesInstituteAnalysis
(* : Contains Untargted data)
(* : Contains raw data)
ST000640 Targeted NEFA in American Indian Adolescents (part I) Homo sapiens Mayo Clinic MS 2021-01-19 1 153 Not available
ST000641 Targeted Amino Acids in American Indian Adolescents (part II) Homo sapiens Mayo Clinic MS 2020-06-26 1 153 Not available