Summary of project PR000603
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR000603. The data can be accessed directly via it's Project DOI: 10.21228/M8QQ3S This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
| Project ID: | PR000603 |
| Project DOI: | doi: 10.21228/M8QQ3S |
| Project Title: | Causal genetic variation underlying metabolome differences |
| Project Summary: | A goal of biology is to predict the phenotypes of individuals, such as side effects to drugs, from their genotypes. Genetic variants that cause disease can change an individual’s total metabolite profile, or metabolome. Understanding the function of these genetic variants may help predict novel phenotypes. We used an unbiased method in yeast to show that genetic differences in two genes change the levels of several urea cycle metabolites. Leveraging knowledge of the urea cycle, we then predicted and validated the sensitivity of yeast strains to a particular drug. The interpretability of our results demonstrates the promise of using genetic variants underlying differences in the metabolome to predict novel phenotypes from genotype. |
| Institute: | Washington University in St. Louis |
| Last Name: | Swain Lenz |
| First Name: | Devjanee |
| Address: | 4515 McKinley Avenue, Saint Louis, Missouri, 63110, USA |
| Email: | devjanee.swain.lenz@duke.edu |
| Phone: | 314-362-3679 |
Summary of all studies in project PR000603
| Study ID | Study Title | Species | Institute | Analysis(* : Contains Untargted data) | Release Date | Version | Samples | Download(* : Contains raw data) |
|---|---|---|---|---|---|---|---|---|
| ST000868 | Untargeted metabolomic profile of oak and wine yeast strains | Saccharomyces cerevisiae | Washington University in St. Louis | MS* | 2017-11-20 | 1 | 51 | Uploaded data (507.4M)* |
| ST000870 | Untargeted metabolomic profile of Saccharomyces cerevisiae (F2) hybrids (part II) | Saccharomyces cerevisiae | Washington University in St. Louis | MS* | 2017-11-20 | 1 | 479 | Uploaded data (508.9M)* |
| ST000871 | Untargeted metabolomic profile of reciprocal hemizygotes (oak/win hybrid, genes AUA1, ARG82) (part III) | Saccharomyces cerevisiae | Washington University in St. Louis | MS* | 2017-11-20 | 1 | 58 | Uploaded data (507.5M)* |
