Summary of project PR000611
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR000611. The data can be accessed directly via it's Project DOI: 10.21228/M8XQ41 This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
| Project ID: | PR000611 |
| Project DOI: | doi: 10.21228/M8XQ41 |
| Project Title: | Metabolomics analysis of leprosy patients with type 1 reaction |
| Project Type: | MS qualitative analysis and identification of polyunsaturated fatty acids in retrospective serum samples of leprosy patients with type 1 reaction |
| Project Summary: | Type 1 reaction (T1R) is an acute inflammatory episode that causes severe neuronal damages in patients with leprosy. The factors that trigger this pathology is still unknown, and further studies are needed to understand T1R and to early prevent its start. It is well established that the host immune response is linked to T1R and previous studies indicated that the metabolism of the host also influences the adaptive immune response against M. leprae antigens. Therefore, metabolomics-based analyses of sera from 7 patients with and 9 without T1R were conducted via liquid chromatography–mass spectrometry. The main goal of this project was to determine whether the metabolism of polyunsaturated fatty acids (such as eicosanoids and omega-3 fatty acids) were perturbed in leprosy patients with T1R. |
| Institute: | Colorado State University |
| Department: | Department of Microbiology, Immunology, and Pathology |
| Laboratory: | Belisle |
| Last Name: | Belisle |
| First Name: | John |
| Address: | Rampart Road, 1682 Campus Delivery |
| Email: | cadriano@rams.colostate.edu |
| Phone: | 9704819160 |
| Funding Source: | This work was supported by the New York Community Trust (grant to J. T. B. as co–principle investigator [PI]), by the Heiser Foundation (grant to J. T. B. as co-PI), and by the Brazilian Coordination for the Improvement of Higher Education Personnel through the Science without Borders program (10546-13-8, for the postdoctoral scholarship to C. A. M. S.). |
| Project Comments: | The institutional review boards of Colorado State University approved the use of sera for the reported study. |
| Publications: | J Infect Dis. 2017 Feb 1;215(3):431-439. doi: 10.1093/infdis/jiw541. |
| Contributors: | Carlos A. M. Silva, Kristofor Webb, Barbara G. Andre, Maria Angela Marques, Fernanda Marques Carvalho, Cristiana Santos de Macedo, Roberta Olmo Pinheiro, Euzenir Nunes Sarno, Maria Cristina Vidal Pessolani, John T. Belisle. |
Summary of all studies in project PR000611
| Study ID | Study Title | Species | Institute | Analysis(* : Contains Untargted data) | Release Date | Version | Samples | Download(* : Contains raw data) |
|---|---|---|---|---|---|---|---|---|
| ST000881 | Targeted metabolomics data of leprosy patients with type 1 reaction | Homo sapiens | Colorado State University | MS* | 2017-08-02 | 1 | 16 | Uploaded data (0.9G)* |
| ST000882 | Untargeted metabolomics data of leprosy patients with type 1 reaction | Homo sapiens | Colorado State University | MS | 2017-06-19 | 1 | 16 | Uploaded data (18.5M)* |
