Summary of project PR000619

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench,, where it has been assigned Project ID PR000619. The data can be accessed directly via it's Project DOI: 10.21228/M8NT1F This work is supported by NIH grant, U2C- DK119886.


Project ID: PR000619
Project DOI:doi: 10.21228/M8NT1F
Project Title:Endogenous Retinoid X Receptor Ligands in Mouse Hemotopoietic Cells
Project Type:MS Identification and Quantification of Ligands
Project Summary:The retinoid X receptor α (RXRA) has been implicated in diverse hematological processes. However, it is unknown whether natural ligands of RXRA are present or regulated in hematopoietic cells. We quantified lipids in the serum of mice treated with a vitamin A deficient diet, a fatty acid deficient diet, and following phenylhydrazine treatment. In parallel, these serum samples were applied to RXRA reporter cells to identify conditions which contained increased concentrations of natural RXRA ligands. Mass spectrometry quantification of serum lipids was correlated with data from the RXRA reporter cells to identify serum lipids that increased in conditions associated with augmented RXRA ligand concentrations in the RXRA reporter assay.
Institute:Washington University in St. Louis
Department:Diabetic Cardiovascular Disease Center
Laboratory:Metabolomics Core
Last Name:Fujiwara
First Name:Hideji
Address:660 South Euclide Avenue, St. Lois, MO 63110
Funding Source:NIH R01 HL128447, NIH P30 DK020579
Publications:Science Signaling 2018, being accepted for publication
Contributors:Haixia Niu, Hideji Fujiwara, Orsola di Martino, Gayla Hadwiger, Thomas E. Frederick, María P. Menéndez-Gutiérrez, Mercedes Ricote, Gregory R. Bowman, John S. Welch

Summary of all studies in project PR000619

Study IDStudy TitleSpeciesInstituteAnalysis
(* : Contains Untargted data)
(* : Contains raw data)
ST000890 Identification of RXR Ligands Mus musculus Washington University in St. Louis MS 2017-10-22 1 129 Not available