Summary of project PR000633

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR000633. The data can be accessed directly via it's Project DOI: 10.21228/M8V961 This work is supported by NIH grant, U2C- DK119886.

See: https://www.metabolomicsworkbench.org/about/howtocite.php

Project ID: PR000633
Project DOI:doi: 10.21228/M8V961
Project Title:Biomarkers of NAFLD progression: a lipidomics approach to an epidemic
Project Type:Lipidomics Study
Project Summary:The spectrum of nonalcoholic fatty liver disease (NAFLD) includes steatosis, nonalcoholic steatohepatitis (NASH), and cirrhosis. Recognition and timely diagnosis of these different stages, particularly NASH, is important for both potential reversibility and limitation of complications. Liver biopsy remains the clinical standard for definitive diagnosis. Diagnostic tools minimizing the need for invasive procedures or that add information to histologic data are important in novel management strategies for the growing epidemic of NAFLD. We describe an 'omics' approach to detecting a reproducible signature of lipid metabolites, aqueous intracellular metabolites, SNPs, and mRNA transcripts in a double-blinded study of patients with different stages of NAFLD that involves profiling liver biopsies, plasma, and urine samples. Using linear discriminant analysis, a panel of 20 plasma metabolites that includes glycerophospholipids, sphingolipids, sterols, and various aqueous small molecular weight components involved in cellular metabolic pathways, can be used to differentiate between NASH and steatosis. This identification of differential biomolecular signatures has the potential to improve clinical diagnosis and facilitate therapeutic intervention of NAFLD.
Institute:University of California, San Diego
Department:Bioengineering
Last Name:Fahy
First Name:Eoin
Address:9500 Gilman, La Jolla, CA, 92093, USA
Email:efahy@ucsd.edu
Phone:858-534-4076
Funding Source:NIGMS Grant GM U54069338
Publications:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4340319/
Contributors:LIPID MAPS Consortium

Summary of all studies in project PR000633

Study IDStudy TitleSpeciesInstituteAnalysis
(* : Contains Untargted data)
Release
Date
VersionSamplesDownload
(* : Contains raw data)
ST000915 Biomarkers of NAFLD progression: a lipidomics approach to an epidemic. Part 1:Liver Homo sapiens LIPID MAPS MS 2018-04-05 1 88 Uploaded data (27.8M)
ST000916 Biomarkers of NAFLD progression: a lipidomics approach to an epidemic. Part 2:Plasma Homo sapiens LIPID MAPS MS 2018-04-05 1 88 Uploaded data (27.8M)*
ST000917 Biomarkers of NAFLD progression: a lipidomics approach to an epidemic. Part 3:Urine Homo sapiens LIPID MAPS MS 2018-04-05 1 88 Uploaded data (27.8M)
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