Summary of project PR000696
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR000696. The data can be accessed directly via it's Project DOI: 10.21228/M8Q96S This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
| Project ID: | PR000696 |
| Project DOI: | doi: 10.21228/M8Q96S |
| Project Title: | Pregnancy Eating and Postpartum Diapers (PEAPOD) |
| Project Type: | Pilot Study |
| Project Summary: | This was a pilot study (n=27), to assess the feasibility, acceptability, and preliminary efficacy of implementing a randomized controlled trial of a diet intervention in pregnancy designed to test the effect of maternal diet on the maternal and infant gut microbiome. Our specific aims were to: 1) test feasibility of enrollment and implementation; 2) assess acceptability of weekly food deliveries; and 3) estimate the preliminary effect size of the intervention relative to the usual care group on (a) maternal gut butyrate composition measured in three maternal stool samples collected at two time points during pregnancy (pre- and post-diet intervention phase) and also collected at 6 weeks postpartum; and (b) infant gut butyrate composition measured in infant stool samples collected at 6 weeks of age. The overall goal of PEAPOD was to gather pilot data to effectively refine the intervention so that it can be tested in a larger, longer study using a factorial design. For this pilot, we employed a 2-arm RCT with a total sample size of 27 mother-child pairs. We enrolled women in mid-pregnancy who were intending to breastfeed, randomized them to the diet intervention (n=13) or to a usual care group (n=14) and followed them to 6 weeks postpartum. Data collection included surveys of detailed maternal dietary information, as well as collection of maternal blood, urine, and stool at three time points (25 and 36 weeks gestation, and 6 weeks postpartum), and an infant stool sample at 6 weeks of age along with information about infant feeding practices. The diet intervention was initiated at 32 weeks gestation and continued until birth of the baby; thus the 25 week gestation biospecimens are pre-intervention and the 36 week gestation biospecimens are after 4 weeks of receiving the diet intervention. We chose to collect the second set of biospecimens at 36 weeks gestation to avoid missing post-intervention samples in instances where women delivered preterm. We partnered with the hospital catering service and the diet intervention including either legumes (e.g. minestrone with white beans) or whole grains (e.g. beef barley), and 5 pieces of fresh fruit (e.g. apples, oranges). In addition, in the first week, participants received a collection of non-perishable high fiber foods (whole wheat breakfast cereal, oatmeal, dried fruit, and canned beans) as well as upscale olive oil and vinegar from a local store along with recipes for salad dressing, side dishes, and some general information about the health benefits of the Mediterranean diet. We anticipated that participants would likely share the food with their families but our intent was to provide enough supplementary food to increase the fiber consumption of the pregnant women. |
| Institute: | Michigan State University |
| Department: | Department of Epidemiology and Biostatistics |
| Last Name: | Kerver |
| First Name: | Jean |
| Address: | 314 Munson Professional Building, MSU/CHM Research, 1105 Sixth Street, Traverse City, MI 49684 |
| Email: | kerverje@msu.edu |
| Phone: | 231-392-8227 |
| Contributors: | Jean Kerver, Sarah Comstock, Joseph Gardiner, Robert Wright, Lauren Petrick, Douglas Walker |
Summary of all studies in project PR000696
| Study ID | Study Title | Species | Institute | Analysis(* : Contains Untargted data) | Release Date | Version | Samples | Download(* : Contains raw data) |
|---|---|---|---|---|---|---|---|---|
| ST001040 | Maternal gut microbiome, pregnancy exposure to environmental contaminants, and child health outcomes: A pilot study exploring potential effect modifications by diet | Homo sapiens | Icahn School of Medicine at Mount Sinai | MS* | 2024-12-31 | 1 | 34 | Uploaded data (11.5G)* |
