Summary of project PR000917
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR000917. The data can be accessed directly via it's Project DOI: 10.21228/M8568J This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
| Project ID: | PR000917 |
| Project DOI: | doi: 10.21228/M8568J |
| Project Title: | Restriction of essential amino acids dictates the systemic metabolic response to dietary protein dilution |
| Project Summary: | The data provided here are in support of the publication “Restriction of essential amino acids dictates the systemic metabolic response to dietary protein dilution” Yann W. Yap et al. Nature Communications 2020 (accepted for publication). Here we provide untargeted metabolomics LC-MS data from liver and plasma from mice fed a diet in which dietary protein was restricted and corresponding unrestricted controls. Specifically, part 1 and 2 correspond to liver and plasma from the hepatic portal vein respectively from animals on a low-protein diet following a week of diet adaptation and correspond controls with n = 5 for each group. Part 3 of the data presented here corresponds to liver from mice subject to a 3wk treatment with diets either containing 18% digestible energy from amino acids or a diet with restricted amounts of threonine and following prior treatments with adeno-associated viruses to transduce the liver to express yeast threonine biosynthetic enzymes (AAV-yTHR1+THR4) or a negative control (AAV-GFP). n= 6 individual mice per group. |
| Institute: | Monash University |
| Department: | Department of Biochemistry and Molecular Biology |
| Laboratory: | Nutrient Metabolism and Signalling Laboratory |
| Last Name: | Rose |
| First Name: | Adam |
| Address: | Monash University, Clayton Campus, 23 Innovation Walk, Clayton, Victoria, 3800, Australia |
| Email: | adam.rose@monash.edu |
| Phone: | +61 3 99029340 |
Summary of all studies in project PR000917
| Study ID | Study Title | Species | Institute | Analysis(* : Contains Untargted data) | Release Date | Version | Samples | Download(* : Contains raw data) |
|---|---|---|---|---|---|---|---|---|
| ST001346 | Metabolomic changes in mouse liver on a protein restricted diet (part-I) | Mus musculus | Monash University | MS* | 2020-07-20 | 1 | 10 | Uploaded data (1.3G)* |
| ST001347 | Metabolomic changes in mouse plasma on a protein restricted diet (part-II) | Mus musculus | Monash University | MS* | 2020-07-20 | 1 | 10 | Uploaded data (1.3G)* |
| ST001348 | Metabolomic changes in mouse liver on a threonine restricted diet (part-III) | Mus musculus | Monash University | MS* | 2020-07-20 | 1 | 24 | Uploaded data (2.8G)* |
