Summary of project PR000967
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR000967. The data can be accessed directly via it's Project DOI: 10.21228/M8PX1S This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
| Project ID: | PR000967 |
| Project DOI: | doi: 10.21228/M8PX1S |
| Project Title: | Plasma metabolites of lipid metabolism associate with diabetic polyneuropathy in a cohort with screen-tested type 2 diabetes: ADDITION-Denmark |
| Project Summary: | The global rise in type 2 diabetes (T2D) is associated with a concomitant increase in diabetic complications. Diabetic polyneuropathy (DPN), the most frequent T2D complication, is characterized by sensory peripheral nerve damage. Although managing glucose effectively slows DPN progression in type 1 diabetes patients, it has limited efficacy in neuropathic T2D patients. The metabolic syndrome (MetS) recently emerged as a major risk factor for DPN; however, the metabolites associated with MetS that correlate with DPN are unknown. We conducted a global plasma metabolomics analysis from a cohort of patients enrolled in the Anglo-Danish-Dutch study of Intensive Treatment of Diabetes in Primary Care (ADDITION), including healthy control subjects, T2D patients, and T2D DPN patients. We identified 15 total plasma metabolites that were altered in T2D DPN patients, including lipids, amino acids, and energy-related metabolites. We evaluated the correlation between these metabolites and all lipid species to identify major changes in both plasma free fatty acids and complex lipids in T2D DPN patients, and found significant alterations in the abundance of long-chain saturated fatty acids, acylcarnitines, and sphingolipids. Our study suggests that DPN in T2D is associated with novel alterations in plasma metabolites related to lipid metabolism. |
| Institute: | University of Michigan |
| Department: | Neurology |
| Laboratory: | Feldman's lab |
| Last Name: | Feldman |
| First Name: | Eva |
| Address: | 5017 AATBSRB, 109 Zina Pitcher Place, Ann Arbor, MI 48109-2200 |
| Email: | efeldman@med.umich.edu |
| Phone: | 7347637274 |
| Funding Source: | Support for this research was provided by the Novo Nordisk Foundation through a Novo Nordisk Foundation Challenge Programme grant (NNF14OC0011633), the National Institutes of Health (1R24082841, 1R21NS102924, and 1DP3DK094292), the National Institute for Diabetes and Digestive and Kidney Diseases (NIDDK) (1F32DK112642 and 1K99DK119366), the American Diabetes Association (7-12-BS-045), the NeuroNetwork for Emerging Therapies, and the A. Alfred Taubman Medical Research Institute. |
Summary of all studies in project PR000967
| Study ID | Study Title | Species | Institute | Analysis(* : Contains Untargted data) | Release Date | Version | Samples | Download(* : Contains raw data) |
|---|---|---|---|---|---|---|---|---|
| ST001411 | Plasma metabolites of lipid metabolism associate with diabetic polyneuropathy in a cohort with screen-tested type 2 diabetes: ADDITION-Denmark | Homo sapiens | University of Michigan | MS | 2021-06-15 | 1 | 106 | Uploaded data (1.9M) |
