Summary of project PR000987
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR000987. The data can be accessed directly via it's Project DOI: 10.21228/M8410G This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
| Project ID: | PR000987 |
| Project DOI: | doi: 10.21228/M8410G |
| Project Title: | Gut microbiota mediates the interplay between immunity and glucose metabolism |
| Project Type: | preclinical studies |
| Project Summary: | Diabetes, obesity and metabolic disease have reached epidemic proportions. Much research on these diseases has focused on tissues such as adipose, liver, muscle and pancreas. The role of the gut in glucose metabolism is relatively unstudied; however, it can also have a significant effect on systemic glucose control. Residing in the gut is a complex community of microbes, termed microbiota, which are important contributors to immunity and metabolism, frequently mediating cross-talks between these two functions. Changes in the gut microbiota of type 2 diabetes (T2D) patients are directly linked to metabolic dysregulation in the disease. Therefore, the goal of the project is to identify and test microbes and microbial factors involved in regulation of glucose metabolism. For this, microbiota perturbation by western diet followed by global analyses of gut microbiome and host transcriptome combined with causal inference analysis is employed. Newly inferred probiotics are tested in mice fed with western diet followed by metabolomics analysis. This research provides a mechanistic explanation of how probiotics helps disclose mechanisms of T2D as well as will identify protective microbial factors for development of therapy of diabetes. |
| Institute: | Oregon State University |
| Department: | Pharmaceutical Sciences |
| Laboratory: | Morgun and Shulzhenko |
| Last Name: | Andriy |
| First Name: | Morgun |
| Address: | 203 Pharmacy Bldg, Corvallis, OR 97331 |
| Email: | andriy.morgun@oregonstate.edu |
| Phone: | 1 541 737 8047 |
| Funding Source: | NIH R01 DK103761 |
Summary of all studies in project PR000987
| Study ID | Study Title | Species | Institute | Analysis(* : Contains Untargted data) | Release Date | Version | Samples | Download(* : Contains raw data) |
|---|---|---|---|---|---|---|---|---|
| ST001436 | Transkingdom interactions between Lactobacilli and hepatic mitochondria attenuate western diet induced diabetes | Mus musculus | Oregon State University | MS* | 2020-09-21 | 1 | 10 | Uploaded data (8.7G)* |
