Summary of project PR001005

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench,, where it has been assigned Project ID PR001005. The data can be accessed directly via it's Project DOI: 10.21228/M8SH6G This work is supported by NIH grant, U2C- DK119886.


Project ID: PR001005
Project DOI:doi: 10.21228/M8SH6G
Project Title:The effect of fasting and sirtuin overexpression on serum metabolome.
Project Type:metabolomics
Project Summary:The levels of the sirtuins SIRT1 and SIRT6 are regulated by nutrient availability in several mammalian tissues. In addition, overexpressing SIRT1 in mice improves healthspan, while SIRT6 overexpression increases both healthspan and lifespan. However, little is known about the impact of these sirtuins at the in vivo metabolomics level. Thus, we performed metabolomics on serum taken from 15 months old male mice overexpressing SIRT1, SIRT6 and SIRT1+SIRT6 as well as WT controls. Sera were obtained from mice at three nutritional time points - at fed state, after 4h morning fast and after 16h fast.
Institute:Bar Ilan University
Department:The Mina & Everard Goodman Faculty of Life Sciences
Laboratory:Laboratory of Prof. Haim Cohen
Last Name:Haim
First Name:Cohen
Address:Bar Ilan University, Ramat Gan, Israel, 5290002
Funding Source:Intramural Research Program of the National Institute on Aging, NIH

Summary of all studies in project PR001005

Study IDStudy TitleSpeciesInstituteAnalysis
(* : Contains Untargted data)
(* : Contains raw data)
ST001523 The effect of fasting and sirtuin overexpression on serum metabolome. Mus musculus Bar Ilan University MS 2021-03-11 1 75 Uploaded data (702.9M)*