Summary of project PR001053

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench,, where it has been assigned Project ID PR001053. The data can be accessed directly via it's Project DOI: 10.21228/M8KQ59 This work is supported by NIH grant, U2C- DK119886.


Project ID: PR001053
Project DOI:doi: 10.21228/M8KQ59
Project Title:Non-Invasive Plasma Glycomic and Metabolic Biomarkers of Post-treatment Control of HIV
Project Summary:Non-invasive biomarkers that predict HIV remission after antiretroviral therapy (ART) interruption are urgently needed. Such biomarkers can improve the safety of analytic treatment interruption (ATI) and provide mechanistic insights into the pathways involved in post-ART HIV control. We identified plasma glycomic and metabolic signatures of time-to-viral-rebound and probability-of-viral-rebound using samples from two independent cohorts. These samples include a large number of post-treatment controllers, a rare population demonstrating sustained virologic suppression after ART-cessation. The signatures remained significant after adjusting for key demographic and clinical confounders. We also confirmed a mechanistic link between biomarkers and HIV latency reactivation and myeloid inflammation in vitro. Finally, machine learning algorithms selected sets of biomarkers that predict time-to-viral-rebound with 74-76% capacity and probability-of-viral-rebound with 97.5% capacity. In summary, we fill a major gap in HIV cure research by identifying non-invasive biomarkers, with potential functional significance, that predict duration and probability of viral remission after treatment interruption.
Institute:The Wistar Institute
Last Name:Abdel-Mohsen
First Name:Mohamed
Address:3601 Spruce St, Philadelphia, PA 19104

Summary of all studies in project PR001053

Study IDStudy TitleSpeciesInstituteAnalysis
(* : Contains Untargted data)
(* : Contains raw data)
ST001719 Metabolomics Analysis of Philadelphia Cohort - Update (part-I) Homo sapiens The Wistar Institute MS 2021-05-25 1 28 Uploaded data (3.7G)*
ST001720 Metabolomics Analysis of ACTG Cohort -Update (part-II) Homo sapiens The Wistar Institute MS 2021-05-25 1 81 Uploaded data (8.4G)*