Summary of project PR001065

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench,, where it has been assigned Project ID PR001065. The data can be accessed directly via it's Project DOI: 10.21228/M81Q3K This work is supported by NIH grant, U2C- DK119886.


Project ID: PR001065
Project DOI:doi: 10.21228/M81Q3K
Project Title:Plasmodium falciparum metabolomics as a result of treatment with putative acetyl-CoA synthetase inhibitors
Project Summary:Plasmodium falciparum is the most virulent species of parasites that cause malaria. Current drug efforts that are used to combat this deadly disease often employ pharmacologic strategies that inhibit critical parasite metabolic functions. Compounds used in the present study have generated resistance mutations in major acetyl-CoA producing enzymes. Hence, we set out to test the metabolic effects of these compounds on Plasmodium falciparum parasites including those on acetyl-CoA production by treating parasites for 2.5 hours under 10xIC50 of the test compounds. We used a targeted HPLC/mass spectrometry-based approach to analyze parasite metabolism. We find that multiple compounds tested in these studies have led to relative decreases in acetyl-CoA abundance compared to control parasite conditions. These studies are necessary for understanding pharmacology effects on the most virulent human malaria parasite.
Institute:Pennsylvania State University
Laboratory:Llinás Laboratory
Last Name:Llinás
First Name:Manuel
Address:W126 Millennium Science Complex, University Park, PENNSYLVANIA, 16802, USA
Funding Source:This work was supported by the Bill and Melinda Gates Foundation (OPP1054480)

Summary of all studies in project PR001065

Study IDStudy TitleSpeciesInstituteAnalysis
(* : Contains Untargted data)
(* : Contains raw data)
ST001660 Plasmodium falciparum metabolomics as a result of treatment with putative acetyl-CoA synthetase inhibitors Plasmodium falciparum Pennsylvania State University MS 2021-06-01 1 54 Uploaded data (1.9G)*